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Monitoring Dialysis Outcomes Initiative

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https://www.readbyqxmd.com/read/27827911/changes-in-body-composition-in-the-two-years-after-initiation-of-haemodialysis-a-retrospective-cohort-study
#1
David Keane, Claire Gardiner, Elizabeth Lindley, Simon Lines, Graham Woodrow, Mark Wright
Malnutrition is common in haemodialysis (HD) and is linked to poor outcomes. This study aimed to describe changes in body composition after the initiation of HD and investigate whether any routinely collected parameters were associated with these changes. The study cohort came from the HD population of a single centre between 2009 and 2014. Body composition measurements were obtained from a database of bioimpedance results using the Body Composition Monitor (BCM), while demographics and laboratory values came from the renal unit database...
November 4, 2016: Nutrients
https://www.readbyqxmd.com/read/27182000/preservation-of-residual-kidney-function-in-hemodialysis-patients-reviving-an-old-concept
#2
REVIEW
Anna T Mathew, Steven Fishbane, Yoshitsugu Obi, Kamyar Kalantar-Zadeh
Residual kidney function (RKF) may confer a variety of benefits to patients on maintenance dialysis. RKF provides continuous clearance of middle molecules and protein-bound solutes. Whereas the definition of RKF varies across studies, interdialytic urine volume may emerge as a pragmatic alternative to more cumbersome calculations. RKF preservation is associated with better patient outcomes including survival and quality of life and is a clinical parameter and research focus in peritoneal dialysis. We propose the following practical considerations to preserve RKF, especially in newly transitioned (incident) hemodialysis patients: (1) periodic monitoring of RKF in hemodialysis patients through urine volume and including residual urea clearance with dialysis adequacy and outcome markers such as anemia, fluid gains, minerals and electrolytes, nutritional, status and quality of life; (2) avoidance of nephrotoxic agents such as radiocontrast dye, nonsteroidal anti-inflammatory drugs, and aminoglycosides; (3) more rigorous hypertension control and minimizing intradialytic hypotensive episodes; (4) individualizing the initial dialysis prescription with consideration of an incremental/infrequent approach to hemodialysis initiation (e...
August 2016: Kidney International
https://www.readbyqxmd.com/read/27094625/unraveling-the-relationship-between-mortality-hyponatremia-inflammation-and-malnutrition-in-hemodialysis-patients-results-from-the-international-mondo-initiative
#3
M J E Dekker, D Marcelli, B Canaud, C J A M Konings, K M Leunissen, N W Levin, P Carioni, V Maheshwari, J G Raimann, F M van der Sande, L A Usvyat, P Kotanko, J P Kooman
BACKGROUND/OBJECTIVES: Hyponatremia is a risk factor for mortality in hemodialysis (HD) patients. It is not well known to which extent the comorbidities, malnutrition, fluid status imbalance and inflammation are related to hyponatremia and affect outcomes. SUBJECTS/METHODS: We studied 8883 patients from the European subset of the international MONitoring Dialysis Outcomes initiative. Nutritional and fluid statuses were assessed by bioimpedance spectroscopy. Fluid depletion was defined as overhydration⩽-1...
July 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27066945/outcomes-of-arteriovenous-fistulas-and-grafts-with-or-without-intervention-before-successful-use
#4
James C Harms, Sunil Rangarajan, Carlton J Young, Jill Barker-Finkel, Michael Allon
OBJECTIVE: Arteriovenous fistulas (AVFs) are considered superior to arteriovenous grafts (AVGs) because of longer secondary patency after successful cannulation for dialysis. We evaluated whether access interventions before successful cannulation affect the relative longevity of AVFs and AVGs after successful use. METHODS: This retrospective study of a prospective database identified patients who initiated dialysis with a catheter and subsequently had a permanent access (289 AVFs and 310 AVGs) placed between January 1, 2006, and December 31, 2011, and were successfully cannulated for dialysis at a large medical center...
July 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27017936/predicting-risk-of-chronic-kidney-disease-in-infants-and-young-children-at-diagnosis-of-posterior-urethral-valves-initial-ultrasound-kidney-characteristics-and-validation-of-parenchymal-area-as-forecasters-of-renal-reserve
#5
Rakan Odeh, Damien Noone, Paul R Bowlin, Luis H P Braga, Armando J Lorenzo
PURPOSE: There is paucity of validated objective early imaging markers to help predict future renal deterioration in infants with posterior urethral valves. We evaluated the prognostic value of total renal parenchymal area, renal echogenicity and corticomedullary differentiation regarding future development of chronic kidney disease. MATERIALS AND METHODS: We analyzed initial postnatal ultrasonographic images from serial posterior urethral valve cases seen at a single tertiary referral center using National Institutes of Health sponsored image processing software...
September 2016: Journal of Urology
https://www.readbyqxmd.com/read/27006497/improving-outcomes-in-patients-receiving-dialysis-the-peer-kidney-care-initiative
#6
James B Wetmore, David T Gilbertson, Jiannong Liu, Allan J Collins
The past decade has witnessed a marked reduction in mortality rates among patients receiving maintenance dialysis. However, the reasons for this welcome development are uncertain, and greater understanding is needed to translate advances in care into additional survival gains. To fill important knowledge gaps and to enable dialysis provider organizations to learn from one another, with the aim of advancing patient care, the Peer Kidney Care Initiative (Peer) was created in 2014 by the chief medical officers of 14 United States dialysis provider organizations and the Chronic Disease Research Group...
July 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/26985383/hemodialysis-outcomes-in-a-global-sample-of-children-and-young-adult-hemodialysis-patients-the-piccolo-mondo-cohort
#7
Maria Ferris, Keisha Gibson, Brett Plattner, Debbie S Gipson, Peter Kotanko, Daniele Marcelli, Cristina Marelli, Michael Etter, Paola Carioni, Gero von Gersdorff, Xiaoqi Xu, Jeroen P Kooman, Qingqing Xiao, Frank M van der Sande, Albert Power, Roberto Picoits-Filho, Lucimary Sylvestre, Katherine Westreich, Len Usvyat
BACKGROUND: The aim of this study was to describe the experience of pediatric and young adult hemodialysis (HD) patients from a global cohort. METHODS: The Pediatric Investigation and Close Collaborative Consortium for Ongoing Life Outcomes for MONitoring Dialysis Outcomes (PICCOLO MONDO) study provided de-identified electronic information of 3244 patients, ages 0-30 years from 2000 to 2012 in four regions: Asia, Europe, North America and South America. The study sample was categorized into pediatric (≤18 years old) and young adult (19-30 years old) groups based on the age at dialysis initiation...
April 2016: Clinical Kidney Journal
https://www.readbyqxmd.com/read/26945054/frequent-monitoring-of-mineral-metabolism-in-hemodialysis-patients-with-secondary-hyperparathyroidism-associations-with-achievement-of-treatment-goals-and-with-adjustments-in-therapy
#8
Keitaro Yokoyama, Noriaki Kurita, Shingo Fukuma, Tadao Akizawa, Masafumi Fukagawa, Yoshihiro Onishi, Kiyoshi Kurokawa, Shunichi Fukuhara
BACKGROUND: Dialysis guidelines in Japan recommend more frequent measurement of mineral metabolism markers than the Kidney Disease: Improving Global Outcomes guidelines. However, the extent to which frequent marker measurement contributes to achievement of target ranges and to therapy adjustment is unknown. METHODS: This multicenter cohort study involved 3276 hemodialysis patients with secondary hyperparathyroidism. Data on laboratory measurements and drug prescriptions were collected every 3 months...
March 3, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/26936151/dietary-management-of-incremental-transition-to-dialysis-therapy-once-weekly-hemodialysis-combined-with-low-protein-diet
#9
Piergiorgio Bolasco, Adamasco Cupisti, Francesco Locatelli, Stefania Caria, Kamyar Kalantar-Zadeh
Initiation of thrice-weekly hemodialysis often results in a rapid loss of residual kidney function (RKF) including reduction in urine output. Preserving RKF longer is associated with better outcomes including greater survival in dialysis patients. An alternative approach aimed at preserving RKF is an incremental transition with less frequent hemodialysis sessions at the beginning with gradual increase in hemodialysis frequency over months. In addition to favorable clinical and economic implications, an incremental transition would also enhance a less stressful adaptation of the patient to dialysis therapy...
November 2016: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/26881430/pediatric-continuous-renal-replacement-therapy
#10
Zaccaria Ricci, Stuart L Goldstein
BACKGROUND: Continuous renal replacement therapy (CRRT) and peritoneal dialysis are the preferred forms of dialysis delivery in critically ill children for the treatment of severe acute kidney injury. The epidemiology and the outcome of acute pediatric dialysis will be reviewed. SUMMARY: The prospective pediatric CRRT (pCRRT) registry has provided important epidemiologic information: pCRRT is required in about 5% of patients in pediatric intensive care units, and the mortality rate of these patients is about 60%...
2016: Contributions to Nephrology
https://www.readbyqxmd.com/read/26846675/three-times-weekly-post-dialysis-cefepime-therapy-in-patients-on-maintenance-hemodialysis-a-retrospective-study
#11
Eric Descombes, Filipe Martins, Ould Maouloud Hemett, Veronique Erard, Christian Chuard
BACKGROUND: In hemodialysis patients, post-dialysis treatment with intravenous antibiotics permits even severe infections to be managed on an outpatient basis. Cefepime is a fourth-generation cephalosporin with a broad spectrum of action in monotherapy. We report on the pharmacokinetics of cefepime in post-dialysis therapy. METHODS: Since June 2012, twelve infections were treated with post-dialysis cefepime in 9 patients on high-flux hemodialysis. The initial post-dialysis dose of cefepime was approximately 15 mg/kg...
2016: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/26664206/adequacy-of-twice-weekly-hemodialysis-in-end-stage-renal-disease-patients-at-a-tertiary-care-dialysis-centre
#12
R Chauhan, S Mendonca
Hemodialysis has improved the morbidity and mortality associated with end stage renal disease. In India, hemodialysis prescription is empiric, which leads to complications related to under-dialysis. Hence, adequacy of hemodialysis in Indian setting was analyzed in this study. A total of 50 patients on twice per week hemodialysis were assessed for 1 month. The number of sessions meeting standards laid out by Kidney Diseases Outcome Quality Initiatives (KDOQI) guidelines were calculated. They were divided into two groups: one in whom dialysis was monitored and session length enhanced to meet the minimum standard Kt/V of 2 and second control group; where Kt/V was not monitored...
November 2015: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/26613220/neonates-with-inborn-errors-of-metabolism-spectrum-and-short-term-outcomes-at-a-tertiary-care-hospital
#13
Mehmet Gündüz, Sevim Ünal, İlyas Okur, İclal Ayrancı Sucaklı, Fatma Güzel, Nevra Koç
We aimed to evaluate the neonates diagnosed as IEM in our neonatal intensive care unit and their outcomes. Among 2994 neonates hospitalized, 51 were diagnosed as IEM (1.7%). Admission complaints were poor feeding, decreased activity, jaundice, seizures, abnormal screening and respiratory problems. Phenylketonuria (11), organic acidemias (8), maple syrup urine disease (5), citrullinemia (5), galactosemia (4), nonketotic hyperglycinemia (4) and tyrosinemia (2) were the most commonly diagnosed IEMs. The follow-up period was 2...
January 2015: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/26524949/vascular-access-monitoring-and-surveillance-an-update
#14
REVIEW
Amanda Valliant, Kathryn McComb
Vascular access in dialysis patients remains both a critical link to survival and a significant source of morbidity. Currently, the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF-KDOQI) vascular access guidelines recommend routine vascular access monitoring and encourage dedicated surveillance techniques to be used for early detection of access stenosis and prevention of thrombosis. There is a paucity of clear evidence supporting 1 surveillance technique over another. The purpose of this review is to describe the benefits and limitations of various surveillance techniques commonly used in the care of dialysis patients...
November 2015: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/26463283/general-anesthesia-is-not-necessary-for-hemodialysis-access-surgery
#15
Jerry J Kim, Gurpreet Dhaliwal, Gloria Y Kim, Edward D Gifford, Huan Yan, Matthew Koopmann, Timothy Ryan, Carlos Donayre, Rodney White, Jeanette Derdemezi, Christian DeVirgilio
Chronic kidney disease has been identified as a risk factor for mortality after procedures under general anesthesia (GA). However, a recent study showed that 85 per cent of arteriovenous fistulas in the United States are performed under GA. Our aim was to demonstrate that GA can be avoided in patients with chronic kidney disease and end-stage renal disease by using local anesthesia (LA) with monitored anesthesia care or brachial plexus block (BPB) during hemodialysis access surgery. A retrospective review was performed at a single institution...
October 2015: American Surgeon
https://www.readbyqxmd.com/read/26457284/oliguria-as-an-early-indicator-of-mortality-risk-in-patients-with-multiple-myeloma-and-renal-impairment
#16
Sung-Hoon Jung, Jae-Sook Ahn, Deok-Hwan Yang, Min-Seok Cho, Jae-Yong Kim, Seo-Yeon Ahn, Yeo-Kyeoung Kim, Hyeoung-Joon Kim, Je-Jung Lee
BACKGROUND: A change in urine output has been recently recognized as a valuable biomarker of acute kidney injury that is associated with mortality in critically ill patients. We investigated the prognostic impact of oliguria for survival outcomes in multiple myeloma (MM) patients presenting with renal impairment (RI). METHODS: Retrospective data on 98 patients with MM and RI, who received initial treatment with novel therapies, were analyzed. Oliguria was defined as a urine output of <0...
September 2015: Blood Research
https://www.readbyqxmd.com/read/26381503/how-the-target-hemoglobin-of-renal-anemia-should-be
#17
REVIEW
Imari Mimura, Tetsuhiro Tanaka, Masaomi Nangaku
Renal anemia is caused by the deficiency of endogenous erythropoietin (Epo) due to renal dysfunction. We think that it is possible to slow the progression of chronic kidney disease (CKD) in case we initiate Epo early in pre-dialysis patients, especially in the non-diabetic population. Erythropoiesis stimulating agent (ESA) treatments targeting mild anemia (10-12 g/dl) can decrease the risk of occurrence of cardiovascular disease (CVD) in patients with hypertension, diabetes mellitus and congestive heart failure...
2015: Nephron
https://www.readbyqxmd.com/read/26223346/association-between-pre-hemodialysis-serum-sodium-concentration-and-blood-pressure-results-from-a-retrospective-analysis-from-the-international-monitoring-dialysis-outcomes-mondo-initiative
#18
J G Raimann, B Canaud, M Etter, J P Kooman, N W Levin, D Marcelli, C Marelli, A Power, N Duncan, F M van der Sande, P Carioni, S Thijssen, X Xu, L A Usvyat, Y Wang, P Kotanko
A recent study from the United Kingdom indicates an association between pre hemodialysis (HD) serum sodium (SNa(+)) and systolic and diastolic blood pressure (SBP and DBP) in chronic HD patients. We extend this analysis to an international cohort of incident HD patients. The Monitoring Dialysis Outcomes initiative encompasses patients from 41 countries. Over 2 years monthly pre-HD SNa(+) levels were used as predictors of pre-HD SBP and DBP in a linear mixed model (LMM) adjusted for age, gender, interdialytic weight gain, diabetes, serum albumin and calcium...
July 2016: Journal of Human Hypertension
https://www.readbyqxmd.com/read/26222557/therapeutic-hypothermia-in-deceased-organ-donors-and-kidney-graft-function
#19
RANDOMIZED CONTROLLED TRIAL
Claus U Niemann, John Feiner, Sharon Swain, Scott Bunting, Melissa Friedman, Megan Crutchfield, Kristine Broglio, Ryutaro Hirose, John P Roberts, Darren Malinoski
BACKGROUND: Delayed graft function, which is reported in up to 50% of kidney-transplant recipients, is associated with increased costs and diminished long-term graft function. The effect that targeted mild hypothermia in organ donors before organ recovery has on the rate of delayed graft function is unclear. METHODS: We enrolled organ donors (after declaration of death according to neurologic criteria) from two large donation service areas and randomly assigned them to one of two targeted temperature ranges: 34 to 35°C (hypothermia) or 36...
July 30, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26210441/a-novel-in-vitro-method-to-model-the-fate-of-subcutaneously-administered-biopharmaceuticals-and-associated-formulation-components
#20
Hanne M Kinnunen, Vikas Sharma, Luis Rodrigo Contreras-Rojas, Yafei Yu, Chlöe Alleman, Alavattam Sreedhara, Stefan Fischer, Leslie Khawli, Stefan T Yohe, Daniela Bumbaca, Thomas W Patapoff, Ann L Daugherty, Randall J Mrsny
Subcutaneous (SC) injection is becoming a more common route for the administration of biopharmaceuticals. Currently, there is no reliable in vitro method that can be used to anticipate the in vivo performance of a biopharmaceutical formulation intended for SC injection. Nor is there an animal model that can predict in vivo outcomes such as bioavailability in humans. We address this unmet need by the development of a novel in vitro system, termed Scissor (Subcutaneous Injection Site Simulator). The system models environmental changes that a biopharmaceutical could experience as it transitions from conditions of a drug product formulation to the homeostatic state of the hypodermis following SC injection...
September 28, 2015: Journal of Controlled Release: Official Journal of the Controlled Release Society
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