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https://www.readbyqxmd.com/read/24164825/solid-tumors-following-kidney-transplantation-in-children
#1
Jodi M Smith, Karen Martz, Ruth A McDonald, William E Harmon
Kidney transplant recipients have an increased risk of cancer. Data on non-LPD malignancies (solid tumors) in pediatric renal transplant recipients are limited. We performed a cohort study using the NAPRTCS transplant registry to describe the incidence of non-LPD malignancy compared with the general pediatric population. The observed incidence rate of non-LPD malignancy in the NAPRTCS transplant registry was 72.1 per 100,000 person-years (SIR 6.7; 95% CI, 5.3, 8.5); a 6.7-fold increased risk compared with the general pediatric population (10...
December 2013: Pediatric Transplantation
https://www.readbyqxmd.com/read/23281637/pediatric-kidney-transplant-practice-patterns-and-outcome-benchmarks-1987-2010-a-report-of-the-north-american-pediatric-renal-trials-and-collaborative-studies
#2
MULTICENTER STUDY
Jodi M Smith, Karen Martz, Tom D Blydt-Hansen
The NAPRTCS transplant registry has collected clinical information on children undergoing kidney transplantation since 1987 and now includes information on 11 603 kidney transplants in 10 632 patients. Since the first data analysis in 1989, NAPRTCS reports have documented marked improvements in outcome after kidney transplantation in addition to identifying factors associated with both favorable and poor outcomes. Patient demographics have changed over the course of the registry with a decrease in the percentage of white recipients from a high of 72% in 1987 to less than 43% in 2007...
March 2013: Pediatric Transplantation
https://www.readbyqxmd.com/read/21810763/does-allograft-failure-impact-school-attendance-in-children-a-naprtcs-study
#3
COMPARATIVE STUDY
Ashton Chen, Karen Martz, Panduranga Rao
BACKGROUND: Studies show that adult dialysis patients with allograft failure have increased mortality and morbidity on dialysis compared to transplant naïve patients. We previously showed comparable mortality risk in pediatric dialysis patients after allograft failure compared to transplant naïve patients; the impact on morbidity is less clear. Specifically, the effect of allograft failure on school attendance in pediatric patients has not previously been studied. METHODS: Using the North American Pediatric Renal Trials and Collaborative Studies database, we compared school attendance between transplant naïve and allograft failure patients from 1 January 1992 to 31 December 2007...
April 2012: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/21466638/wait-list-status-of-pediatric-dialysis-patients-in-north-america
#4
Stephanie Nguyen, Karen Martz, Don Stablein, Alicia Neu
Kidney transplantation is the treatment of choice for the majority of pediatric patients with end-stage kidney disease. Previous studies demonstrating racial or gender disparities in access to the deceased donor transplant list could not evaluate the impact of medical concerns or patient preference on waitlist status. We undertook a retrospective cohort study using the NAPRTCS registry to begin to determine barriers to wait list registration for kidney transplantation among pediatric dialysis patients. Clinical and demographic factors were compared in listed vs...
June 2011: Pediatric Transplantation
https://www.readbyqxmd.com/read/21446977/improved-survival-with-recent-post-transplant-lymphoproliferative-disorder-ptld-in-children-with-kidney-transplants
#5
V R Dharnidharka, K L Martz, D M Stablein, M R Benfield
Post-transplant lymphoproliferative disorder (PTLD) has been associated with high mortality, but recent anecdotal survival appeared better. From 1988 to 2010, the NAPRTCS registry had 235 registered PTLD cases. We sent a special 25-point questionnaire study to the NAPRTCS centers with the most recent 150 cases to obtain additional follow-up data not collected in the master registry, our objective being to determine the recent outcomes after PTLD and determine prognostic factors. We received 92 completed responses, in which only 12 (13%) deaths were reported, 2 from nonmedical causes, 10 with a functioning graft...
April 2011: American Journal of Transplantation
https://www.readbyqxmd.com/read/21199208/good-outcome-of-kidney-transplants-in-recipients-of-young-donors-a-naprtcs-data-analysis
#6
COMPARATIVE STUDY
Asha Moudgil, Karen Martz, Donald M Stablein, Dechu P Puliyanda
NAPRTCS data were analyzed to assess outcome of TX recipients from YDs (<5 yr) in comparison with IDs (6-35 yr) and ODs (36-55 yr). Of 9854 TX in NAPRTCS (1987-2003), 469 were YD. Patient survival (PS) and graft survival (GS) were compared between DD TX after 1995; 81YD, 1324 ID, and 429 OD and eGFR were compared among functioning grafts (YD 31, ID 439, OD 174) at three yr. PS was comparable in all groups; GS at one, two, and three yr in TX of YD (91.1%, 83.8%, 79.7%), ID (93.5%, 89.7%, 83.6%), and OD (92...
March 2011: Pediatric Transplantation
https://www.readbyqxmd.com/read/21162600/calcineurin-inhibitor-free-immunosuppression-in-pediatric-renal-transplantation-a-viable-option
#7
REVIEW
Britta Höcker, Burkhard Tönshoff
The introduction, in the mid-1980s, of calcineurin inhibitors - namely ciclosporin (cyclosporine) and later tacrolimus - has significantly improved short-term renal graft survival by lowering acute rejection rates in both adult and pediatric kidney transplantation. Nonetheless, long-term transplant survival is still not satisfactory, with calcineurin inhibitor-induced chronic nephrotoxicity being one of the main causes of progressive nephron loss and declining renal transplant function. Hence, different immunosuppressant regimens have been proposed to avoid or ameliorate calcineurin inhibitor-induced nephrotoxicity...
February 1, 2011: Paediatric Drugs
https://www.readbyqxmd.com/read/20711788/mortality-risk-in-children-after-renal-allograft-failure-a-naprtcs-study
#8
COMPARATIVE STUDY
Ashton Chen, Karen Martz, David Kershaw, John Magee, Panduranga S Rao
Studies have shown that adult dialysis patients with a failed renal allograft face a greater risk of mortality on dialysis compared with transplant-naïve patients. The outcome of children returning to dialysis after allograft failure has not been previously studied. Using the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS) registry, we studied patients aged 2-21 years who initiated dialysis from 1 January 1992 to 31 December 2007. Of a total of 5,006 patients, 1,031 patients had a prior history of allograft failure and 3,975 did not (transplant-naïve)...
December 2010: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/20464428/risk-for-anemia-in-pediatric-chronic-kidney-disease-patients-a-report-of-naprtcs
#9
Meredith A Atkinson, Karen Martz, Bradley A Warady, Alicia M Neu
Previous studies in children with chronic kidney disease (CKD) have identified low hemoglobin as a risk factor for poor outcomes. A retrospective review of the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS) CKD registry was performed to identify the prevalence of and risk factors for anemia among children with stage 3 CKD, including both patients with low hemoglobin and those whose hemoglobin normalized with an erythropoiesis-stimulating agent (ESA). At enrollment, 2,792 patients had stage 3 CKD...
September 2010: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/20168276/weight-and-height-changes-and-factors-associated-with-greater-weight-and-height-gains-after-pediatric-renal-transplantation-a-naprtcs-study
#10
Bethany J Foster, Karen Martz, Manjula Gowrishankar, Donald Stablein, Amira Al-Uzri
BACKGROUND.: Obesity is a significant problem among children undergoing renal transplantation. We sought to describe changes in adiposity (reflected by percent difference from the median body mass index [BMI] for height-age and sex [BMI%]) after pediatric renal transplantation and to identify risk factors for greater gains in adiposity within 12 months of transplantation and for persistence of these gains at 48 months. The changes in height-for-age were also examined. METHODS.: By using the North American Pediatric Renal Trials and Collaborative Studies registry, we performed a retrospective cohort study of children (age 2-18 years...
May 15, 2010: Transplantation
https://www.readbyqxmd.com/read/20013293/what-have-20-years-of-data-from-the-north-american-pediatric-renal-transplant-cooperative-study-taught-us-about-growth-following-renal-transplantation-in-infants-children-and-adolescents-with-end-stage-renal-disease
#11
REVIEW
Richard N Fine, Karen Martz, Donald Stablein
Growth following renal transplantation in infants, children, and adolescents was evaluated from 20 years of data reported to the registry of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). The analysis of more than 10,000 recipients addressed the following questions: 1. What is the impact of age, pubertal growth, gender, transplant history, donor source and allograft function on growth after transplantation? 2. Has the height Z score at the time of transplantation changed during the past two decades and has this influenced final adult height? 3...
April 2010: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/19686443/variables-affecting-estimated-glomerular-filtration-rate-after-renal-transplantation-in-children-a-naprtcs-data-analysis
#12
A Moudgil, K Martz, D M Stablein, D P Puliyanda
Short-term graft survival has improved in renal transplants without significant effect on long-term graft survival. As GFR decline precedes graft loss, an understanding of variables affecting eGFR after TX may help improve graft survival. NAPRTCS data were analyzed to assess effects of donor, recipient, and other variables on Schwartz eGFR after transplantation. For 8438 children with a functioning graft at day 30, data were censored for children dying with a functioning graft, and those with <3 yr follow-up...
March 2010: Pediatric Transplantation
https://www.readbyqxmd.com/read/19387689/the-effect-of-rhgh-on-height-velocity-and-bmi-in-children-with-ckd-a-report-of-the-naprtcs-registry
#13
Mouin G Seikaly, Pamela Waber, Bradley A Warady, Donald Stablein
The aim of this investigation was to evaluate the impact of recombinant human growth hormone (rhGH) therapy on height velocity (HV), estimated glomerular filtration rate (eGFR) and body mass index (BMI) in a large cohort of children with chronic kidney disease (CKD). We reviewed longitudinal data from patients enrolled in the chronic renal insufficiency registry of the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS). Of the 7189 patients enrolled in the registry, 827 (11.5%) received rhGH...
September 2009: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/19000067/outcomes-of-kidney-transplantation-in-children-with-nephronophthisis-an-analysis-of-the-north-american-pediatric-renal-trials-and-collaborative-studies-naprtcs-registry
#14
Lorraine A Hamiwka, Julian P Midgley, Andrew W Wade, Karen L Martz, Silviu Grisaru
NPHP is an autosomal recessive chronic tubulointerstitial nephropathy that progresses to ESRD. In the 2006 NAPRTCS report, NPHP was the primary diagnosis in 2.8% of all renal transplant patients. At our pediatric center, that covers a population in which the NPHP1 gene is prevalent, 24% of transplant recipients had a primary diagnosis of NPHP. Since no previous literature reports have documented kidney transplant outcomes in patients with NPHP, a review of the 2006 NAPRTCS database was performed. The results of this review illustrate that patients with NPHP as their underlying kidney disease have a significantly better overall graft survival when compared with all other patients registered in the NAPRTCS database...
December 2008: Pediatric Transplantation
https://www.readbyqxmd.com/read/18583762/pediatric-renal-transplantation-a-review-of-data-from-north-american-pediatric-renal-transplant-cooperative-study-naprtcs
#15
P T McEnery
No abstract text is available yet for this article.
1994: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/18179637/recombinant-growth-hormone-use-pretransplant-and-risk-for-post-transplant-lymphoproliferative-disease-a-report-of-the-naprtcs
#16
MULTICENTER STUDY
Vikas R Dharnidharka, Lynya I Talley, Karen L Martz, Donald M Stablein, Richard N Fine
rhGH, widely used to optimize linear growth in children with ESRD, also modulates B-cell precursor development and may be associated with malignancy development. To determine if rhGH use in children was associated with higher risk of PTLD, we analyzed retrospectively collected data on children with CRI, on dialysis or with renal transplants in a large multi-center registry of children with ESRD. Of the 194 LPD patients currently listed in the registry, 41 were previously enrolled in the CRI registry and 18/41 (43...
September 2008: Pediatric Transplantation
https://www.readbyqxmd.com/read/17702713/bk-virus-nephropathy-in-pediatric-renal-transplant-recipients-an-analysis-of-the-north-american-pediatric-renal-trials-and-collaborative-studies-naprtcs-registry
#17
MULTICENTER STUDY
Jodi M Smith, Vikas R Dharnidharka, Lynya Talley, Karen Martz, Ruth A McDonald
BACKGROUND AND OBJECTIVES: There is limited information regarding BK virus nephropathy in pediatric kidney transplantation. The objective of this study was to evaluate cases of BK virus nephropathy in the North American Pediatric Renal Trials and Collaborative Studies database. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Using a questionnaire that was sent to North American Pediatric Renal Trials and Collaborative Studies centers, we assessed the incidence, risk factors, clinical features, and outcomes of BK virus nephropathy in pediatric renal transplant recipients who received a transplant between 2000 and 2004...
September 2007: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/17699460/racial-differences-in-graft-survival-a-report-from-the-north-american-pediatric-renal-trials-and-collaborative-studies-naprtcs
#18
Abiodun Omoloja, Mark Mitsnefes, Lynya Talley, Mark Benfield, Alicia Neu
Multiple studies have documented racial differences in graft survival in kidney transplant recipients. Although several studies in adult kidney transplant recipients have evaluated risk factors that might predispose to these differences, studies in pediatric patients are lacking. This study retrospectively analyzed data from the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS) to identify racial differences in kidney transplant outcomes and evaluate factors that might contribute to those differences...
May 2007: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/17530299/use-of-rhgh-in-children-with-chronic-kidney-disease-lessons-from-naprtcs
#19
COMPARATIVE STUDY
Mouin G Seikaly, Nina Salhab, Bradley A Warady, Donald Stablein
We evaluated the utilization and potential benefits of recombinant human growth hormone (rhGH) in children with chronic kidney disease (CKD) and following renal transplantation in a large patient cohort. We queried the chronic renal insufficiency (CRI), dialysis, and transplant registries of the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS) to characterize the frequency of rhGH utilization, factors related to its usage, and the relationship between rhGH usage and catch-up growth...
August 2007: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/17493215/contributions-of-the-transplant-registry-the-2006-annual-report-of-the-north-american-pediatric-renal-trials-and-collaborative-studies-naprtcs
#20
MULTICENTER STUDY
Jodi M Smith, Donald M Stablein, Ricardo Munoz, Diane Hebert, Ruth A McDonald
This summary of the NAPRTCS 2006 Annual Report of the Transplant Registry highlights the significant impact the registry has had in advancing knowledge in pediatric renal transplantation worldwide. This cooperative group has collected clinical information on children undergoing a renal transplantation since 1987 and now includes over 150 participating medical centers in the USA, Canada, Mexico, and Costa Rica. Currently, the NAPRTCS transplant registry includes information on 9837 renal transplants in 8990 patients (NAPRTCS 2006 Annual Report)...
June 2007: Pediatric Transplantation
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