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"Cancer Fatigue"

Carolina X Sandler, Blake A Hamilton, Sarah L Horsfield, Barbara K Bennett, Ute Vollmer-Conna, Chris Tzarimas, Andrew R Lloyd
BACKGROUND: Medically-unexplained chronic fatigue states are prevalent, and challenging to manage. Cognitive behavioural therapy (CBT) and graded exercise therapy (GET) are effective in clinical trials. Evaluation of delivery in a standard health care setting is rare. An integrated treatment program with individualised allocation of resources to patients' needs, was developed and implemented though an academic outpatient clinic. It was hypothesised that the program would result in similar responses to those observed in the clinical trials...
September 13, 2016: Internal Medicine Journal
Shirin M Shallwani, Maureen J Simmonds, Goulnar Kasymjanova, Jadranka Spahija
OBJECTIVES: Our objectives were: (a) to identify predictors of change in health-related quality of life (HRQOL) in patients with advanced non-small cell lung cancer (NSCLC) undergoing chemotherapy; and (b) to characterize symptom status, nutritional status, physical performance and HRQOL in this population and to estimate the extent to which these variables change following two cycles of chemotherapy. METHODS: A secondary analysis of a longitudinal observational study of 47 patients (24 men and 23 women) with newly diagnosed advanced NSCLC receiving two cycles of first-line chemotherapy was performed...
September 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Andreas Charalambous, Christiana Kouta
Cancer related fatigue (CRF) is a common and debilitating symptom that can influence quality of life (QoL) in cancer patients. The increase in survival times stresses for a better understanding of how CRF affects patients' QoL. This was a cross-sectional descriptive study with 148 randomly recruited prostate cancer patients aiming to explore CRF and its impact on QoL. Assessments included the Cancer Fatigue Scale, EORTC QLQ-C30, and EORTC QLQ-PR25. Additionally, 15 in-depth structured interviews were performed...
2016: BioMed Research International
Eudocia Q Lee, Alona Muzikansky, Jan Drappatz, Santosh Kesari, Eric T Wong, Camilo E Fadul, David A Reardon, Andrew D Norden, Lakshmi Nayak, Mikael L Rinne, Brian M Alexander, Nils D Arvold, Lisa Doherty, Jennifer Stefanik, Debra LaFrankie, Sandra F Ruland, Julee Pulverenti, Katrina H Smith, Sarah C Gaffey, Samantha Hammond, Patrick Y Wen
BACKGROUND: Fatigue is common among glioma patients undergoing radiotherapy (RT) and impacts quality of life (QOL). We evaluated whether armodafinil, a wakefulness-promoting medication, improves fatigue in glioma patients undergoing RT. METHODS: Eligibility criteria included age ≥18 years, Karnofsky performance status ≥60, and grade 2-4 glioma undergoing RT to a total dose of 50-60 Gy. Patients were randomized 1:1 to armodafinil or placebo for 8 weeks beginning within 10 days of starting RT...
June 2016: Neuro-oncology
Julie M Cessna, Heather S L Jim, Steven K Sutton, Yasmin Asvat, Brent J Small, John M Salsman, Babu Zachariah, Mayer Fishman, Teresa Field, Hugo Fernandez, Lia Perez, Paul B Jacobsen
OBJECTIVE: Fatigue is common among cancer patients and adversely impacts quality of life. As such, it is important to measure fatigue accurately in a way that is not burdensome to patients. The 7-item Patient Reported Outcome Measurement Information System (PROMIS) Cancer Fatigue Short Form scale was recently developed using item response theory (IRT). The current study evaluated the psychometric properties of this scale in two samples of cancer patients using classical test theory (CTT)...
February 2016: Journal of Psychosomatic Research
Sara H Olson, Youming Xu, Keri Herzog, Amethyst Saldia, Ersilia M DeFilippis, Peter Li, Peter J Allen, Eileen M O'Reilly, Robert C Kurtz
OBJECTIVES: We aimed to determine the severity and co-occurrence of established and potential paraneoplastic conditions in pancreatic cancer (weight loss, new onset diabetes, fatigue, and depression) and their relation to patient characteristics. METHODS: Using information from personal interviews with 510 cases and 463 controls, we obtained adjusted odds ratios for weight loss, long-term and new-onset diabetes, fatigue, and depression before diagnosis. Among cases, we investigated the extent to which these factors occurred together and the characteristics of those reporting them...
August 2016: Pancreas
Xia Wang, Jie You
OBJECTIVE: To evaluate the clinical efficacy of Yiqi Jianpi Recipe (YJR) in treating cancer-related fatigue (CRF) after chemotherapy in lung cancer patients. Methods Totally 124 lung cancer patients were assigned to the treatment group (63 cases) and the control group (61 cases) according to random digit table. All patients received pre-set chemotherapy regimens according their conditions. Patients in the treatment group took YJR Decoction from the 1st day of chemotherapy, one dose per day for 2 successive weeks, while those in the control group took no Chinese medical decoction...
September 2015: Chinese Journal of Integrated Traditional and Western Medicine
Charles E Heckler, Sheila N Garland, Anita R Peoples, Michael L Perlis, Michelle Shayne, Gary R Morrow, Charles Kamen, Jenine Hoefler, Joseph A Roscoe
PURPOSE: Fatigue is a prevalent, distressing side effect of cancer and cancer treatment which commonly coexists with insomnia. Cognitive behavioral therapy for insomnia (CBT-I) has been shown to improve insomnia in cancer patients, but less is known about its ability to impact fatigue. This work is the analysis for a secondary aim of a four-arm randomized controlled trial (RCT) study assessing the combined and comparative effect of CBT-I and a wakefulness-promoting agent, armodafinil (A), to improve sleep and daytime functioning in cancer survivors...
May 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Tami Borneman
CASE STUDY  Mr. G., an 82-year-old retired European man, was diagnosed with stage 4 non-small cell lung cancer (NSCLC) and recently enrolled on a phase II clinical trial. He is married and has two adult children, who are very supportive. He and his wife described themselves as nonpracticing Catholics. He had never smoked, and there was no personal or family history of cancer. Fatigue was the main side effect from the clinical trial drugs, necessitating frequent periods of rest throughout the day and ultimately requiring dose reduction...
November 2014: Journal of the Advanced Practitioner in Oncology
Alex Rua Rodrigues, Damila Cristina Trufelli, Fernando Fonseca, Larissa Carvalho de, Auro Del Giglio
PURPOSE: To assess which laboratory and clinical factors are associated with fatigue in patients with terminal cancer. METHODS: We evaluated 51 patients with advanced incurable solid tumors using the Chalder Fatigue Questionnaire (CFQ) and the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale for fatigue; the Pittsburgh Sleep Quality Index (PSQI-BR) for sleep quality; the Hospital Anxiety and Depression Scale (HADS) for anxiety and depression; the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire, Version 3...
August 30, 2015: American Journal of Hospice & Palliative Care
Ann M Berger, Kathi Mooney, Amy Alvarez-Perez, William S Breitbart, Kristen M Carpenter, David Cella, Charles Cleeland, Efrat Dotan, Mario A Eisenberger, Carmen P Escalante, Paul B Jacobsen, Catherine Jankowski, Thomas LeBlanc, Jennifer A Ligibel, Elizabeth Trice Loggers, Belinda Mandrell, Barbara A Murphy, Oxana Palesh, William F Pirl, Steven C Plaxe, Michelle B Riba, Hope S Rugo, Carolina Salvador, Lynne I Wagner, Nina D Wagner-Johnston, Finly J Zachariah, Mary Anne Bergman, Courtney Smith
Cancer-related fatigue is defined as a distressing, persistent, subjective sense of physical, emotional, and/or cognitive tiredness or exhaustion related to cancer or cancer treatment that is not proportional to recent activity and interferes with usual functioning. It is one of the most common side effects in patients with cancer. Fatigue has been shown to be a consequence of active treatment, but it may also persist into posttreatment periods. Furthermore, difficulties in end-of-life care can be compounded by fatigue...
August 2015: Journal of the National Comprehensive Cancer Network: JNCCN
Andrea Cercek, Jennifer Wheler, Peter E Murray, Shawn Zhou, Leonard Saltz
INTRODUCTION: This phase I, multicenter, open-label, single-arm, dose-escalation study evaluated the safety, pharmacokinetics and antitumor activity of APTO-253, an inducer of the transcription factor KLF4, in adults with advanced solid tumors. METHODS: APTO-253 was administered IV on days 1 and 2, and 15 and 16 of each 28 day cycle; the dose were escalated from 20 to 387 mg/m(2) in 9 cohorts until DLT was observed. RESULTS: Thirty-two patients were treated on this trial (50 % colon cancer, 22 % other gastrointenstinal malignancies and 18 % non-small cell lung cancer)...
October 2015: Investigational New Drugs
Rajath Othayoth, Pardhasaradhi Mathi, Khaggeswar Bheemanapally, Lavanya Kakarla, Mahendran Botlagunta
CONTEXT: Vitamins have been shown to reduce chemotherapy-related fatigue (CRF) by conserving energy loss both during and after cancer treatment. However, it remains unknown whether this reduction of fatigue interferes with the cancer drugs or alters the effectiveness of these agents. OBJECTIVES: The objective was to synthesize vitamin-cisplatin-loaded chitosan nano-particles for chemoprevention and cancer fatigue. MATERIALS AND METHODS: Multi-vitamin (C, D3, and B12)-cisplatin composite nano-formulation called NanoCisVital (NCV) to overcome CRF...
2015: Journal of Microencapsulation
Laura Deckx, Doris L van Abbema, Marjan van den Akker, Carine van den Broeke, Mieke van Driel, Paul Bulens, Vivianne C G Tjan-Heijnen, Cindy Kenis, Eric T de Jonge, Bert Houben, Frank Buntinx
BACKGROUND: Although older cancer survivors commonly report psychosocial problems, the impact of both cancer and ageing on the occurrence of these problems remains largely unknown. The evolution of depression, cognitive functioning, and fatigue was evaluated in a group of older cancer patients in comparison with a group of younger cancer patients and older persons without cancer. METHODS: Older (≥70 years) and younger cancer patients (50-69 years) with breast or colorectal cancer stage I-III, and older persons without cancer (≥70 years) were included...
2015: BMC Geriatrics
Leorey N Saligan, Karin Olson, Kristin Filler, David Larkin, Fiona Cramp, Sriram Yennurajalingam, Carmen P Escalante, Auro del Giglio, Kord M Kober, Jayesh Kamath, Oxana Palesh, Karen Mustian
No abstract text is available yet for this article.
September 2015: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Julienne E Bower, Patricia A Ganz
Fatigue and cognitive complaints commonly occur during adjuvant chemotherapy treatment of breast cancer. Fatigue is also associated with radiation therapy, and can occur with surgery alone. Both of these symptoms may persist beyond the initial treatment of breast cancer and they have taken on greater prominence with the growing number of breast cancer survivors. These symptoms are most troublesome when patients try to resume their pre-illness activities (e.g., work, household responsibilities) and find that they are limited...
2015: Advances in Experimental Medicine and Biology
Leorey N Saligan, Karin Olson, Kristin Filler, David Larkin, Fiona Cramp, Sriram Yennurajalingam, Yennu Sriram, Carmen P Escalante, Auro del Giglio, Kord M Kober, Jayesh Kamath, Oxana Palesh, Karen Mustian
PURPOSE: Understanding the etiology of cancer-related fatigue (CRF) is critical to identify targets to develop therapies to reduce CRF burden. The goal of this systematic review was to expand on the initial work by the National Cancer Institute CRF Working Group to understand the state of the science related to the biology of CRF and, specifically, to evaluate studies that examined the relationships between biomarkers and CRF and to develop an etiologic model of CRF to guide researchers on pathways to explore or therapeutic targets to investigate...
August 2015: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Geoffrey K Mitchell, Janet R Hardy, Catherine J Nikles, Sue-Ann S Carmont, Hugh E Senior, Philip J Schluter, Phillip Good, David C Currow
CONTEXT: Fatigue is common in life-limiting cancer. Methylphenidate (MPH), a psychostimulant, may be a useful therapy. Gathering evidence in patients with advanced cancer can be challenging. OBJECTIVES: To determine if MPH improves cancer-related fatigue in people with advanced cancer. METHODS: N-of-1 trials are multicycle, double-blind, randomized, controlled crossover trials using standardized measures of effect in individuals. They are normally used to assess treatment effects in individuals...
September 2015: Journal of Pain and Symptom Management
Celestia S Higano, Tomasz M Beer, Mary-Ellen Taplin, Eleni Efstathiou, Mohammad Hirmand, David Forer, Howard I Scher
BACKGROUND: Given that some patients with castration-resistant prostate cancer (CRPC) have shown extended responses to the androgen receptor inhibitor enzalutamide, long-term safety of this drug is of interest. OBJECTIVE: To evaluate the long-term safety and antitumor activity of enzalutamide in CRPC patients. DESIGN, SETTING, AND PARTICIPANTS: This phase 1-2 study evaluated enzalutamide in 140 CRPC patients with and without prior chemotherapy...
November 2015: European Urology
Kazue Hirai, Kiyoko Kanda, Junko Takagai, Mai Hosokawa
PURPOSE: The purpose of this study was to develop the Hirai Cancer Fatigue Scale (HCFS) to assess the fatigue experienced by cancer patients, and to verify its reliability and validity. METHODS: Based on qualitative research about the perception of fatigue by Japanese cancer patients, we developed a questionnaire. The content validity was confirmed by 5 expert oncology nurses and 5 oncologists. 281 Japanese cancer patients participated in this study. Construct validity was analyzed using factor analysis, and internal consistency was analyzed using Cronbach's α coefficient...
August 2015: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
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