Keith S Kaye, Dror Marchaim, Visanu Thamlikitkul, Yehuda Carmeli, Cheng-Hsun Chiu, George Daikos, Sorabh Dhar, Emanuele Durante-Mangoni, Achilles Gikas, Anastasia Kotanidou, Mical Paul, Emmanuelle Roilides, Michael Rybak, Michael Samarkos, Matthew Sims, Dora Tancheva, Sotirios Tsiodras, Daniel Kett, Gopi Patel, David Calfee, Leonard Leibovici, Laura Power, Sylvia Munoz-Price, Kurt Stevenson, Laura Susick, Katie Latack, Jolene Daniel, Christine Chiou, George W Divine, Varduhi Ghazyaran, Jason M Pogue
BACKGROUND: Pneumonia and bloodstream infections (BSI) due to extensively drug-resistant (XDR) Acinetobacter baumannii , XDR Pseudomonas aeruginosa , and carbapenem-resistant Enterobacterales (CRE) are associated with high mortality rates, and therapeutic options remain limited. This trial assessed whether combination therapy with colistin and meropenem was superior to colistin monotherapy for the treatment of these infections. METHODS: The OVERCOME (Colistin Monotherapy versus Combination Therapy) trial was an international, randomized, double-blind, placebo-controlled trial...
January 2023: NEJM Evid