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TBI Neuroimaging

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https://www.readbyqxmd.com/read/27919750/mapping-the-functional-connectome-in-traumatic-brain-injury-what-can-graph-metrics-tell-us
#1
Karen Caeyenberghs, Helena Verhelst, Adam Clemente, Peter H Wilson
OBJECTIVE: Traumatic brain injury (TBI) is associated with cognitive and motor deficits, and poses a significant personal, societal, and economic burden. One mechanism by which TBI is thought to affect cognition and behaviour is through changes in functional connectivity. Graph theory is a powerful framework for quantifying topological features of neuroimaging-derived functional networks. The objective of this paper is to review studies examining functional connectivity in TBI with an emphasis on graph theoretical analysis that is proving to be valuable in uncovering network abnormalities in this condition...
December 2, 2016: NeuroImage
https://www.readbyqxmd.com/read/27885947/quickbrain-mri-for-the-detection-of-acute-pediatric-traumatic-brain-injury
#2
David C Sheridan, Craig D Newgard, Nathan R Selden, Mubeen A Jafri, Matthew L Hansen
OBJECTIVE The current gold-standard imaging modality for pediatric traumatic brain injury (TBI) is CT, but it confers risks associated with ionizing radiation. QuickBrain MRI (qbMRI) is a rapid brain MRI protocol that has been studied in the setting of hydrocephalus, but its ability to detect traumatic injuries is unknown. METHODS The authors performed a retrospective cohort study of pediatric patients with TBI who were undergoing evaluation at a single Level I trauma center between February 2010 and December 2013...
November 25, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27834545/advanced-neuroimaging-to-quantify-myelin-in-vivo-application-to-mild-tbi
#3
S M Jurick, K J Bangen, N D Evangelista, M Sanderson-Cimino, L Delano-Wood, A J Jak
BACKGROUND: Difficulty providing accurate diagnosis and prognosis, especially after mild forms of traumatic brain injury (TBI), has increased efforts to detect changes in white matter microstructure using advanced neuroimaging techniques. Although methods such as diffusion tensor imaging (DTI) have greatly increased knowledge of white matter changes resulting from TBI, several shortcomings limit the utility of these techniques particularly when applied to populations with mild TBI (mTBI) history...
2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27805992/volumetric-analysis-of-day-of-injury-computed-tomography-is-associated-with-rehabilitation-outcomes-after-traumatic-brain-injury
#4
Sarah Majercik, Joseph Bledsoe, David Ryser, Ramona O Hopkins, Joseph E Fair, R Brock Frost, Joel MacDonald, Ryan Barrett, Susan Horn, David Pisani, Erin D Bigler, Scott Gardner, Mark Stevens, Michael J Larson
INTRODUCTION: Day-of-injury (DOI) brain lesion volumes in traumatic brain injury (TBI) patients are rarely used to predict long-term outcomes in the acute setting. The purpose of this study was to investigate the relationship between acute brain injury lesion volume and rehabilitation outcomes in patients with TBI at a Level One Trauma Center. METHODS: Patients with TBI who were admitted to our rehabilitation unit after the acute care trauma service from February 2009-July 2011 were eligible for the study...
October 31, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27763536/fluid-biomarkers-of-traumatic-brain-injury-and-intended-context-of-use
#5
Tanya Bogoslovsky, Jessica Gill, Andreas Jeromin, Cora Davis, Ramon Diaz-Arrastia
Traumatic brain injury (TBI) is one of the leading causes of death and disability around the world. The lack of validated biomarkers for TBI is a major impediment to developing effective therapies and improving clinical practice, as well as stimulating much work in this area. In this review, we focus on different settings of TBI management where blood or cerebrospinal fluid (CSF) biomarkers could be utilized for predicting clinically-relevant consequences and guiding management decisions. Requirements that the biomarker must fulfill differ based on the intended context of use (CoU)...
October 18, 2016: Diagnostics
https://www.readbyqxmd.com/read/27747595/a-semi-automated-workflow-solution-for-multimodal-neuroimaging-application-to-patients-with-traumatic-brain-injury
#6
Koon-Pong Wong, Marvin Bergsneider, Thomas C Glenn, Vladimir Kepe, Jorge R Barrio, David A Hovda, Paul M Vespa, Sung-Cheng Huang
Traumatic brain injury (TBI) is a major cause of mortality and morbidity, placing a significant financial burden on the healthcare system worldwide. Non-invasive neuroimaging technologies have been playing a pivotal role in the study of TBI, providing important information for surgical planning and patient management. Advances in understanding the basic mechanisms and pathophysiology of the brain following TBI are hindered by a lack of reliable image analysis methods for accurate quantitative assessment of TBI-induced structural and pathophysiological changes seen on anatomical and functional images obtained from multiple imaging modalities...
March 2016: Brain Informatics
https://www.readbyqxmd.com/read/27738990/cognitive-fatigue-is-associated-with-reduced-anterior-internal-capsule-integrity-in-veterans-with-history-of-mild-to-moderate-traumatic-brain-injury
#7
Alexandra L Clark, Lisa Delano-Wood, Scott F Sorg, Madeleine L Werhane, Karen L Hanson, Dawn M Schiehser
No known studies have directly examined white matter microstructural correlates of cognitive fatigue post-TBI in a Veteran sample. We therefore investigated the relationship between cognitive fatigue and white matter integrity in Veterans with history of mild to moderate TBI (mmTBI). 59 Veterans (TBI = 34, Veteran Controls [VCs] = 25]) with and without history of mmTBI underwent structural 3T DTI scans and completed questionnaires related to cognitive fatigue and psychiatric symptoms. Tractography was employed on six regions of interest, including the anterior and posterior limbs of the internal capsule; genu; body and splenium of the corpus callosum; and cingulum bundle...
October 6, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27632903/fluid-biomarkers-for-mild-traumatic-brain-injury-and-related-conditions
#8
REVIEW
Henrik Zetterberg, Kaj Blennow
Diagnostic and prognostic biomarkers for mild traumatic brain injury (TBI), also known as concussion, remain a major unmet clinical need. Moderate to severe TBI can be diagnosed definitively by clinical assessment and standard neuroimaging techniques that detect the gross damage to the brain parenchyma. Diagnostic tools for mild TBI are lacking and, currently, the diagnosis has to be made on clinical grounds alone, because most patients show no gross pathological changes on CT. Most patients with mild TBI recover quickly, but about 15% develop an ill-defined condition called postconcussive syndrome (PCS)...
October 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27555810/systems-biology-neuroimaging-neuropsychology-neuroconnectivity-and-traumatic-brain-injury
#9
Erin D Bigler
The patient who sustains a traumatic brain injury (TBI) typically undergoes neuroimaging studies, usually in the form of computed tomography (CT) and magnetic resonance imaging (MRI). In most cases the neuroimaging findings are clinically assessed with descriptive statements that provide qualitative information about the presence/absence of visually identifiable abnormalities; though little if any of the potential information in a scan is analyzed in any quantitative manner, except in research settings. Fortunately, major advances have been made, especially during the last decade, in regards to image quantification techniques, especially those that involve automated image analysis methods...
2016: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/27538439/reconsidering-the-word-memory-test-as-a-memory-measure-in-traumatic-brain-injury
#10
Jeremy J Davis
OBJECTIVE: This study examined relationships among traumatic brain injury (TBI) severity, the Word Memory Test (WMT), and California Verbal Learning Test-Second Edition (CVLT-II). METHOD: Participants (N = 104) passed WMT validity indices and were categorized by TBI severity on the basis of medical records. Outcome measures included norm-referenced scores on the CVLT-II and WMT. RESULTS: Participants grouped by TBI severity significantly differed on the CVLT-II but not WMT...
August 18, 2016: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/27468266/older-age-results-in-differential-gene-expression-after-mild-traumatic-brain-injury-and-is-linked-to-imaging-differences-at-acute-follow-up
#11
Young-Eun Cho, Lawrence L Latour, Hyungsuk Kim, L Christine Turtzo, Anlys Olivera, Whitney S Livingston, Dan Wang, Christiana Martin, Chen Lai, Ann Cashion, Jessica Gill
Older age consistently relates to a lesser ability to fully recover from a traumatic brain injury (TBI); however, there is limited data to explicate the nature of age-related risks. This study was undertaken to determine the relationship of age on gene-activity following a TBI, and how this biomarker relates to changes in neuroimaging findings. A young group (between the ages of 19 and 35 years), and an old group (between the ages of 60 and 89 years) were compared on global gene-activity within 48 h following a TBI, and then at follow-up within 1-week...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27430468/indications-for-the-performance-of-neuroimaging-in-children
#12
Fenella Jane Kirkham
Pediatric neurology relies on ultrasound, computed tomography (CT), and magnetic resonance (MR) imaging. CT prevails in acute neurologic presentations, including traumatic brain injury (TBI), nontraumatic coma, stroke, and status epilepticus, because of easy availability, with images of diagnostic quality, e.g., to exclude hemorrhage, usually completed quickly enough to avoid sedation. Concerns over the risks of ionizing radiation mean re-imaging and higher-dose procedures, e.g., arteriography and venography, require justification...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27199885/neuroimaging-assessment-of-cerebrovascular-reactivity-in-concussion-current-concepts-methodological-considerations-and-review-of-the-literature
#13
REVIEW
Michael J Ellis, Lawrence N Ryner, Olivia Sobczyk, Jorn Fierstra, David J Mikulis, Joseph A Fisher, James Duffin, W Alan C Mutch
Concussion is a form of traumatic brain injury (TBI) that presents with a wide spectrum of subjective symptoms and few objective clinical findings. Emerging research suggests that one of the processes that may contribute to concussion pathophysiology is dysregulation of cerebral blood flow (CBF) leading to a mismatch between CBF delivery and the metabolic needs of the injured brain. Cerebrovascular reactivity (CVR) is defined as the change in CBF in response to a measured vasoactive stimulus. Several magnetic resonance imaging (MRI) techniques can be used as a surrogate measure of CBF in clinical and laboratory studies...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27138134/acute-white-matter-tract-damage-after-frontal-mild-traumatic-brain-injury
#14
Juan J Herrera, Kurt Bockhorst, Shakuntala Kondraganti, Laura Stertz, João Quevedo, Ponnada A Narayana
Our understanding of mild traumatic brain injury (mTBI) is still in its infancy and to gain a greater understanding, relevant animal models should replicate many of the features seen in human mTBI. These include changes to diffusion tensor imaging (DTI) parameters, absence of anatomical lesions on conventional neuroimaging, and neurobehavioral deficits. The Maryland closed head TBI model causes anterior-posterior plus sagittal rotational acceleration of the brain, frequently observed with motor vehicle and sports-related TBI injuries...
June 20, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27065823/concomitant-use-of-transcranial-direct-current-stimulation-and-computer-assisted-training-for-the-rehabilitation-of-attention-in-traumatic-brain-injured-patients-behavioral-and-neuroimaging-results
#15
Katiuscia Sacco, Valentina Galetto, Danilo Dimitri, Elisabetta Geda, Francesca Perotti, Marina Zettin, Giuliano C Geminiani
Divided attention (DA), the ability to distribute cognitive resources among two or more simultaneous tasks, may be severely compromised after traumatic brain injury (TBI), resulting in problems with numerous activities involved with daily living. So far, no research has investigated whether the use of non-invasive brain stimulation associated with neuropsychological rehabilitation might contribute to the recovery of such cognitive function. The main purpose of this study was to assess the effectiveness of 10 transcranial direct current stimulation (tDCS) sessions combined with computer-assisted training; it also intended to explore the neural modifications induced by the treatment...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27034916/a-semi-automated-workflow-solution-for-multimodal-neuroimaging-application-to-patients-with-traumatic-brain-injury
#16
Koon-Pong Wong, Marvin Bergsneider, Thomas C Glenn, Vladimir Kepe, Jorge R Barrio, David A Hovda, Paul M Vespa, Sung-Cheng Huang
Traumatic brain injury (TBI) is a major cause of mortality and morbidity, placing a significant financial burden on the healthcare system worldwide. Non-invasive neuroimaging technologies have been playing a pivotal role in the study of TBI, providing important information for surgical planning and patient management. Advances in understanding the basic mechanisms and pathophysiology of the brain following TBI are hindered by a lack of reliable image analysis methods for accurate quantitative assessment of TBI-induced structural and pathophysiological changes seen on anatomical and functional images obtained from multiple imaging modalities...
2016: Brain Informatics
https://www.readbyqxmd.com/read/27033264/traumatic-brain-injury-changing-concepts-and-approaches
#17
Andrew Maas
Traumatic brain injury (TBI) represents a huge global medical and public health problem across all ages and in all populations. In this review, we discussed the changing concepts and approaches. Globally, the incidence is increasing and in high income countries epidemiologic patterns are changing with consequences for prevention campaigns. TBI should not be viewed as an event, but as a progressive and chronic disease with lifetime consequences. In the clinical field, precision approaches to treatment are being developed, which require more accurate disease phenotyping...
2016: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/27021773/mapping-the-connectome-following-traumatic-brain-injury
#18
REVIEW
Yousef Hannawi, Robert D Stevens
There is a paucity of accurate and reliable biomarkers to detect traumatic brain injury, grade its severity, and model post-traumatic brain injury (TBI) recovery. This gap could be addressed via advances in brain mapping which define injury signatures and enable tracking of post-injury trajectories at the individual level. Mapping of molecular and anatomical changes and of modifications in functional activation supports the conceptual paradigm of TBI as a disorder of large-scale neural connectivity. Imaging approaches with particular relevance are magnetic resonance techniques (diffusion weighted imaging, diffusion tensor imaging, susceptibility weighted imaging, magnetic resonance spectroscopy, functional magnetic resonance imaging, and positron emission tomographic methods including molecular neuroimaging)...
May 2016: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/27007484/traumatic-brain-injury-and-age-at-onset-of-cognitive-impairment-in-older-adults
#19
Wei Li, Shannon L Risacher, Thomas W McAllister, Andrew J Saykin
There is a deficiency of knowledge regarding how traumatic brain injury (TBI) is associated with age at onset (AAO) of cognitive impairment in older adults. Participants with a TBI history were identified from the Alzheimer's disease neuroimaging initiative (ADNI 1/GO/2) medical history database. Using an analysis of covariance (ANCOVA) model, the AAO was compared between those with and without TBI, and potential confounding factors were controlled. The AAO was also compared between those with mild TBI (mTBI) and moderate or severe TBI (sTBI)...
July 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27002352/parental-ratings-of-daily-behavior-and-child-cognitive-test-performance-after-pediatric-mild-traumatic-brain-injury
#20
Jacobus Donders, Christin DeWit
This study aimed to evaluate the degree to which the Behavior Rating Inventory of Executive Function (BRIEF) and Child Behavior Checklist (CBCL) measure overlapping vs. distinct constructs in pediatric patients with mild traumatic brain injury (TBI), and to examine the demographic and injury correlates of such constructs as well as those of cognitive test performance. A total of 100 parents completed the BRIEF and the CBCL within 1 to 12 months after the injury of their child. Groups were contrasted based on the presence vs...
March 22, 2016: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
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