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TBI Neuroimaging

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https://www.readbyqxmd.com/read/28076834/risk-factors-for-posttraumatic-epilepsy-a-systematic-review-and-meta-analysis
#1
REVIEW
Tao Xu, Xinyuan Yu, Shu Ou, Xi Liu, Jinxian Yuan, Hao Huang, Juan Yang, Liang He, Yangmei Chen
OBJECTIVE: A systematic review and meta-analysis was performed to identify risk factors for posttraumatic epilepsy (PTE). METHODS: Two electronic databases (Medline and Embase) were searched to identify studies with a cohort, case-control, or cross-sectional design reporting on epidemiologic evidence regarding risk factors for PTE. RESULTS: Men had a higher risk of developing PTE than women [relative ratio (RR), 1.32; 95% confidence interval (CI), 1...
January 8, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28007768/toward-precision-and-reproducibility-of-diffusion-tensor-imaging-a-multicenter-diffusion-phantom-and-traveling-volunteer-study
#2
E M Palacios, A J Martin, M A Boss, F Ezekiel, Y S Chang, E L Yuh, M J Vassar, D M Schnyer, C L MacDonald, K L Crawford, A Irimia, A W Toga, P Mukherjee
BACKGROUND AND PURPOSE: Precision medicine is an approach to disease diagnosis, treatment, and prevention that relies on quantitative biomarkers that minimize the variability of individual patient measurements. The aim of this study was to assess the intersite variability after harmonization of a high-angular-resolution 3T diffusion tensor imaging protocol across 13 scanners at the 11 academic medical centers participating in the Transforming Research and Clinical Knowledge in Traumatic Brain Injury multisite study...
December 22, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27939821/multimodal-imaging-of-neurometabolic-pathology-due-to-traumatic-brain-injury
#3
REVIEW
John Darrell Van Horn, Avnish Bhattrai, Andrei Irimia
The impact of traumatic brain injury (TBI) involves a combination of complex biochemical processes beginning with the initial insult and lasting for days, months and even years post-trauma. These changes range from neuronal integrity losses to neurotransmitter imbalance and metabolite dysregulation, leading to the release of pro- or anti-apoptotic factors which mediate cell survival or death. Such dynamic processes affecting the brain's neurochemistry can be monitored using a variety of neuroimaging techniques, whose combined use can be particularly useful for understanding patient-specific clinical trajectories...
January 2017: Trends in Neurosciences
https://www.readbyqxmd.com/read/27919750/mapping-the-functional-connectome-in-traumatic-brain-injury-what-can-graph-metrics-tell-us
#4
Karen Caeyenberghs, Helena Verhelst, Adam Clemente, Peter H Wilson
OBJECTIVE: Traumatic brain injury (TBI) is associated with cognitive and motor deficits, and poses a significant personal, societal, and economic burden. One mechanism by which TBI is thought to affect cognition and behavior is through changes in functional connectivity. Graph theory is a powerful framework for quantifying topological features of neuroimaging-derived functional networks. The objective of this paper is to review studies examining functional connectivity in TBI with an emphasis on graph theoretical analysis that is proving to be valuable in uncovering network abnormalities in this condition...
December 3, 2016: NeuroImage
https://www.readbyqxmd.com/read/27885947/quickbrain-mri-for-the-detection-of-acute-pediatric-traumatic-brain-injury
#5
David C Sheridan, Craig D Newgard, Nathan R Selden, Mubeen A Jafri, Matthew L Hansen
OBJECTIVE The current gold-standard imaging modality for pediatric traumatic brain injury (TBI) is CT, but it confers risks associated with ionizing radiation. QuickBrain MRI (qbMRI) is a rapid brain MRI protocol that has been studied in the setting of hydrocephalus, but its ability to detect traumatic injuries is unknown. METHODS The authors performed a retrospective cohort study of pediatric patients with TBI who were undergoing evaluation at a single Level I trauma center between February 2010 and December 2013...
November 25, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27834545/advanced-neuroimaging-to-quantify-myelin-in-vivo-application-to-mild-tbi
#6
S M Jurick, K J Bangen, N D Evangelista, M Sanderson-Cimino, L Delano-Wood, A J Jak
BACKGROUND: Difficulty providing accurate diagnosis and prognosis, especially after mild forms of traumatic brain injury (TBI), has increased efforts to detect changes in white matter microstructure using advanced neuroimaging techniques. Although methods such as diffusion tensor imaging (DTI) have greatly increased knowledge of white matter changes resulting from TBI, several shortcomings limit the utility of these techniques particularly when applied to populations with mild TBI (mTBI) history...
2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27805992/volumetric-analysis-of-day-of-injury-computed-tomography-is-associated-with-rehabilitation-outcomes-after-traumatic-brain-injury
#7
Sarah Majercik, Joseph Bledsoe, David Ryser, Ramona O Hopkins, Joseph E Fair, R Brock Frost, Joel MacDonald, Ryan Barrett, Susan Horn, David Pisani, Erin D Bigler, Scott Gardner, Mark Stevens, Michael J Larson
BACKGROUND: Day-of-injury (DOI) brain lesion volumes in traumatic brain injury (TBI) patients are rarely used to predict long-term outcomes in the acute setting. The purpose of this study was to investigate the relationship between acute brain injury lesion volume and rehabilitation outcomes in patients with TBI at a level one trauma center. METHODS: Patients with TBI who were admitted to our rehabilitation unit after the acute care trauma service from February 2009-July 2011 were eligible for the study...
January 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27763536/fluid-biomarkers-of-traumatic-brain-injury-and-intended-context-of-use
#8
REVIEW
Tanya Bogoslovsky, Jessica Gill, Andreas Jeromin, Cora Davis, Ramon Diaz-Arrastia
Traumatic brain injury (TBI) is one of the leading causes of death and disability around the world. The lack of validated biomarkers for TBI is a major impediment to developing effective therapies and improving clinical practice, as well as stimulating much work in this area. In this review, we focus on different settings of TBI management where blood or cerebrospinal fluid (CSF) biomarkers could be utilized for predicting clinically-relevant consequences and guiding management decisions. Requirements that the biomarker must fulfill differ based on the intended context of use (CoU)...
October 18, 2016: Diagnostics
https://www.readbyqxmd.com/read/27747595/a-semi-automated-workflow-solution-for-multimodal-neuroimaging-application-to-patients-with-traumatic-brain-injury
#9
Koon-Pong Wong, Marvin Bergsneider, Thomas C Glenn, Vladimir Kepe, Jorge R Barrio, David A Hovda, Paul M Vespa, Sung-Cheng Huang
Traumatic brain injury (TBI) is a major cause of mortality and morbidity, placing a significant financial burden on the healthcare system worldwide. Non-invasive neuroimaging technologies have been playing a pivotal role in the study of TBI, providing important information for surgical planning and patient management. Advances in understanding the basic mechanisms and pathophysiology of the brain following TBI are hindered by a lack of reliable image analysis methods for accurate quantitative assessment of TBI-induced structural and pathophysiological changes seen on anatomical and functional images obtained from multiple imaging modalities...
March 2016: Brain Informatics
https://www.readbyqxmd.com/read/27738990/cognitive-fatigue-is-associated-with-reduced-anterior-internal-capsule-integrity-in-veterans-with-history-of-mild-to-moderate-traumatic-brain-injury
#10
Alexandra L Clark, Lisa Delano-Wood, Scott F Sorg, Madeleine L Werhane, Karen L Hanson, Dawn M Schiehser
No known studies have directly examined white matter microstructural correlates of cognitive fatigue post-TBI in a Veteran sample. We therefore investigated the relationship between cognitive fatigue and white matter integrity in Veterans with history of mild to moderate TBI (mmTBI). 59 Veterans (TBI = 34, Veteran Controls [VCs] = 25]) with and without history of mmTBI underwent structural 3T DTI scans and completed questionnaires related to cognitive fatigue and psychiatric symptoms. Tractography was employed on six regions of interest, including the anterior and posterior limbs of the internal capsule; genu; body and splenium of the corpus callosum; and cingulum bundle...
October 6, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27632903/fluid-biomarkers-for-mild-traumatic-brain-injury-and-related-conditions
#11
REVIEW
Henrik Zetterberg, Kaj Blennow
Diagnostic and prognostic biomarkers for mild traumatic brain injury (TBI), also known as concussion, remain a major unmet clinical need. Moderate to severe TBI can be diagnosed definitively by clinical assessment and standard neuroimaging techniques that detect the gross damage to the brain parenchyma. Diagnostic tools for mild TBI are lacking and, currently, the diagnosis has to be made on clinical grounds alone, because most patients show no gross pathological changes on CT. Most patients with mild TBI recover quickly, but about 15% develop an ill-defined condition called postconcussive syndrome (PCS)...
October 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27555810/systems-biology-neuroimaging-neuropsychology-neuroconnectivity-and-traumatic-brain-injury
#12
Erin D Bigler
The patient who sustains a traumatic brain injury (TBI) typically undergoes neuroimaging studies, usually in the form of computed tomography (CT) and magnetic resonance imaging (MRI). In most cases the neuroimaging findings are clinically assessed with descriptive statements that provide qualitative information about the presence/absence of visually identifiable abnormalities; though little if any of the potential information in a scan is analyzed in any quantitative manner, except in research settings. Fortunately, major advances have been made, especially during the last decade, in regards to image quantification techniques, especially those that involve automated image analysis methods...
2016: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/27538439/reconsidering-the-word-memory-test-as-a-memory-measure-in-traumatic-brain-injury
#13
Jeremy J Davis
OBJECTIVE: This study examined relationships among traumatic brain injury (TBI) severity, the Word Memory Test (WMT), and California Verbal Learning Test-Second Edition (CVLT-II). METHOD: Participants (N = 104) passed WMT validity indices and were categorized by TBI severity on the basis of medical records. Outcome measures included norm-referenced scores on the CVLT-II and WMT. RESULTS: Participants grouped by TBI severity significantly differed on the CVLT-II but not WMT...
August 18, 2016: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/27468266/older-age-results-in-differential-gene-expression-after-mild-traumatic-brain-injury-and-is-linked-to-imaging-differences-at-acute-follow-up
#14
Young-Eun Cho, Lawrence L Latour, Hyungsuk Kim, L Christine Turtzo, Anlys Olivera, Whitney S Livingston, Dan Wang, Christiana Martin, Chen Lai, Ann Cashion, Jessica Gill
Older age consistently relates to a lesser ability to fully recover from a traumatic brain injury (TBI); however, there is limited data to explicate the nature of age-related risks. This study was undertaken to determine the relationship of age on gene-activity following a TBI, and how this biomarker relates to changes in neuroimaging findings. A young group (between the ages of 19 and 35 years), and an old group (between the ages of 60 and 89 years) were compared on global gene-activity within 48 h following a TBI, and then at follow-up within 1-week...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27430468/indications-for-the-performance-of-neuroimaging-in-children
#15
Fenella Jane Kirkham
Pediatric neurology relies on ultrasound, computed tomography (CT), and magnetic resonance (MR) imaging. CT prevails in acute neurologic presentations, including traumatic brain injury (TBI), nontraumatic coma, stroke, and status epilepticus, because of easy availability, with images of diagnostic quality, e.g., to exclude hemorrhage, usually completed quickly enough to avoid sedation. Concerns over the risks of ionizing radiation mean re-imaging and higher-dose procedures, e.g., arteriography and venography, require justification...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27199885/neuroimaging-assessment-of-cerebrovascular-reactivity-in-concussion-current-concepts-methodological-considerations-and-review-of-the-literature
#16
REVIEW
Michael J Ellis, Lawrence N Ryner, Olivia Sobczyk, Jorn Fierstra, David J Mikulis, Joseph A Fisher, James Duffin, W Alan C Mutch
Concussion is a form of traumatic brain injury (TBI) that presents with a wide spectrum of subjective symptoms and few objective clinical findings. Emerging research suggests that one of the processes that may contribute to concussion pathophysiology is dysregulation of cerebral blood flow (CBF) leading to a mismatch between CBF delivery and the metabolic needs of the injured brain. Cerebrovascular reactivity (CVR) is defined as the change in CBF in response to a measured vasoactive stimulus. Several magnetic resonance imaging (MRI) techniques can be used as a surrogate measure of CBF in clinical and laboratory studies...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27138134/acute-white-matter-tract-damage-after-frontal-mild-traumatic-brain-injury
#17
Juan J Herrera, Kurt Bockhorst, Shakuntala Kondraganti, Laura Stertz, João Quevedo, Ponnada A Narayana
Our understanding of mild traumatic brain injury (mTBI) is still in its infancy and to gain a greater understanding, relevant animal models should replicate many of the features seen in human mTBI. These include changes to diffusion tensor imaging (DTI) parameters, absence of anatomical lesions on conventional neuroimaging, and neurobehavioral deficits. The Maryland closed head TBI model causes anterior-posterior plus sagittal rotational acceleration of the brain, frequently observed with motor vehicle and sports-related TBI injuries...
June 20, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27065823/concomitant-use-of-transcranial-direct-current-stimulation-and-computer-assisted-training-for-the-rehabilitation-of-attention-in-traumatic-brain-injured-patients-behavioral-and-neuroimaging-results
#18
Katiuscia Sacco, Valentina Galetto, Danilo Dimitri, Elisabetta Geda, Francesca Perotti, Marina Zettin, Giuliano C Geminiani
Divided attention (DA), the ability to distribute cognitive resources among two or more simultaneous tasks, may be severely compromised after traumatic brain injury (TBI), resulting in problems with numerous activities involved with daily living. So far, no research has investigated whether the use of non-invasive brain stimulation associated with neuropsychological rehabilitation might contribute to the recovery of such cognitive function. The main purpose of this study was to assess the effectiveness of 10 transcranial direct current stimulation (tDCS) sessions combined with computer-assisted training; it also intended to explore the neural modifications induced by the treatment...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27034916/a-semi-automated-workflow-solution-for-multimodal-neuroimaging-application-to-patients-with-traumatic-brain-injury
#19
Koon-Pong Wong, Marvin Bergsneider, Thomas C Glenn, Vladimir Kepe, Jorge R Barrio, David A Hovda, Paul M Vespa, Sung-Cheng Huang
Traumatic brain injury (TBI) is a major cause of mortality and morbidity, placing a significant financial burden on the healthcare system worldwide. Non-invasive neuroimaging technologies have been playing a pivotal role in the study of TBI, providing important information for surgical planning and patient management. Advances in understanding the basic mechanisms and pathophysiology of the brain following TBI are hindered by a lack of reliable image analysis methods for accurate quantitative assessment of TBI-induced structural and pathophysiological changes seen on anatomical and functional images obtained from multiple imaging modalities...
2016: Brain Informatics
https://www.readbyqxmd.com/read/27033264/traumatic-brain-injury-changing-concepts-and-approaches
#20
Andrew Maas
Traumatic brain injury (TBI) represents a huge global medical and public health problem across all ages and in all populations. In this review, we discussed the changing concepts and approaches. Globally, the incidence is increasing and in high income countries epidemiologic patterns are changing with consequences for prevention campaigns. TBI should not be viewed as an event, but as a progressive and chronic disease with lifetime consequences. In the clinical field, precision approaches to treatment are being developed, which require more accurate disease phenotyping...
2016: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
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