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TBI Neuroimaging

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https://www.readbyqxmd.com/read/29893758/early-and-rapid-detection-of-uchl1-in-the-serum-of-brain-trauma-patients-a-novel-gold-nanoparticle-based-method-for-diagnosing-the-severity-of-brain-injury
#1
Gyaninder Pal Singh, Richa Nigam, Gaurav Singh Tomar, Mohan Monisha, Sanjeev Kumar Bhoi, Arulselvi S, Kangana Sengar, Deepa Akula, Prashanth Panta, Roy Anindya
The clinical diagnosis of traumatic brain injury (TBI) is based on neurological examination and neuro-imaging tools such as CT scanning and MRI. However, neurological examination at times may be confounded by consumption of alcohol or drugs and neuroimaging facilities may not be available at all centers. Human ubiquitin C-terminal hydrolase (UCHL1) is a well-accepted serum biomarker for severe TBI and can be used to detect the severity of a head injury. A reliable, rapid, cost effective, bedside and easy to perform method for the detection of UCHL1 is a pre-requisite for wide clinical applications of UCHL1 as a TBI biomarker...
June 12, 2018: Analyst
https://www.readbyqxmd.com/read/29878909/neuroimaging-of-brain-trauma
#2
David B Douglas, Jonathan L Muldermans, Max Wintermark
PURPOSE OF REVIEW: The purpose of this review is to provide an update on advanced neuroimaging techniques in traumatic brain injury (TBI). We will focus this review on recent literature published within the last 18 months and the advanced neuroimaging techniques of perfusion imaging and diffusion tensor imaging (DTI). RECENT FINDINGS: In the setting of a moderate or severe acute closed head injury (Glasgow Coma Scale <13), the most appropriate neuroimaging study is a noncontrast computed tomography (CT) scan...
June 6, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29876247/neuroplasticity-of-cognitive-control-networks-following-cognitive-training-for-chronic-traumatic-brain-injury
#3
Kihwan Han, Sandra B Chapman, Daniel C Krawczyk
Cognitive control is the ability to coordinate thoughts and actions to achieve goals. Cognitive control impairments are one of the most persistent and devastating sequalae of traumatic brain injuries (TBI). There have been efforts to improve cognitive control in individuals with post-acute TBI. Several studies have reported changes in neuropsychological measures suggesting the efficacy of cognitive training in improving cognitive control. Yet, the neural substrates of improved cognitive control after training remains poorly understood...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29809237/current-contribution-of-diffusion-tensor-imaging-in-the-evaluation-of-diffuse-axonal-injury
#4
Daphine Centola Grassi, David Macedo da Conceição, Claudia da Costa Leite, Celi Santos Andrade
Traumatic brain injury (TBI) is the number one cause of death and morbidity among young adults. Moreover, survivors are frequently left with functional disabilities during the most productive years of their lives. One main aspect of TBI pathology is diffuse axonal injury, which is increasingly recognized due to its presence in 40% to 50% of all cases that require hospital admission. Diffuse axonal injury is defined as widespread axonal damage and is characterized by complete axotomy and secondary reactions due to overall axonopathy...
March 2018: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29809035/prefrontal-gray-matter-volume-predicts-metacognitive-accuracy-following-traumatic-brain-injury
#5
Emily C Grossner, Rachel A Bernier, Einat K Brenner, Kathy S Chiou, Frank G Hillary
OBJECTIVE: To examine metacognitive ability (MC) following moderate to severe traumatic brain injury (TBI) using an empirical assessment approach and to determine the relationship between alterations in gray matter volume (GMV) and MC. METHOD: A sample of 62 individuals (TBI n = 34; healthy control [HC] n = 28) were included in the study. Neuroimaging and neuropsychological data were collected for all participants during the same visit. MC was quantified using an approach borrowed from signal detection theory (Type II area under the receiver operating characteristic curve calculation) to evaluate judgments during a modified version of the 3rd edition of the Wechsler Adult Intelligence Scale's Matrix Reasoning subtest where half of the items were presented randomly and half were presented in the order of increasing difficulty...
May 2018: Neuropsychology
https://www.readbyqxmd.com/read/29746557/optic-tract-injury-after-closed-head-traumatic-brain-injury-in-mice-a-model-of-indirect-traumatic-optic-neuropathy
#6
Nathan K Evanson, Fernanda Guilhaume-Correa, James P Herman, Michael D Goodman
Adult male C57BL/6J mice have previously been reported to have motor and memory deficits after experimental closed head traumatic brain injury (TBI), without associated gross pathologic damage or neuroimaging changes detectable by magnetic resonance imaging or diffusion tensor imaging protocols. The presence of neurologic deficits, however, suggests neural damage or dysfunction in these animals. Accordingly, we undertook a histologic analysis of mice after TBI. Gross pathology and histologic analysis using Nissl stain and NeuN immunohistochemistry demonstrated no obvious tissue damage or neuron loss...
2018: PloS One
https://www.readbyqxmd.com/read/29734566/hyperbaric-oxygen-for-post-concussive-symptoms-in-united-states-military-service-members-a-randomized-clinical-trial
#7
Lindell K Weaver, Steffanie H Wilson, Anne S Lindblad, Susan Churchill, Kayla Deru, Robert C Price, Chris S Williams, William W Orrison, James M Walker, Anna Meehan, Susan Mirow
Background: In prior military randomized trials, participants with persistent symptoms after mild traumatic brain injury (TBI) reported improvement regardless of receiving hyperbaric oxygen (HBO₂) or sham intervention. This study's objectives were to identify outcomes for future efficacy trials and describe changes by intervention. Methods: This Phase II, randomized, double-blind, sham-controlled trial enrolled military personnel with mild TBI and persistent post-concussive symptoms...
March 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29725174/clinico-radiologic-profile-of-pediatric-traumatic-brain-injury-in-western-rajasthan
#8
Pawan Kumar Dara, Manish Parakh, Shyama Choudhary, Hemant Jangid, Priyanka Kumari, Satyendra Khichar
Objective: The aim of this study was to evaluate clinico-radiological profile and outcome of pediatric traumatic brain injury (TBI). Design: Prospective observational study. Setting: Intensive Care Unit, ward and OPD of Pediatrics, Dr. S. N. Medical College, Jodhpur (tertiary care hospital). Participants: A total of 188 children (1 month-18 years) were enrolled and 108 admitted. Intervention: TBI classified as mild, moderate, or severe TBI...
April 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29714644/functional-outcomes-in-patients-with-co-occurring-traumatic-brain-injury-and-spinal-cord-injury-from-an-inpatient-rehabilitation-facility-s-perspective
#9
Kristin L Garlanger, Lisa A Beck, Andrea L Cheville
OBJECTIVE: To examine the occurrence and severity of co-occurring traumatic brain injury (TBI) in persons with traumatic spinal cord injury (SCI), i.e. dual diagnosis (DD), and to describe differences in functional outcomes between persons with DD and SCI only from an inpatient rehabilitation facility (IRF) perspective. DESIGN: Retrospective clinical chart review. SETTING: Acute Midwest SCI inpatient rehabilitation facility. PARTICIPANTS: 256 persons age 18-80 years with acute traumatic SCI (AIS A-E, C1-S3 level of injury) from 2002-2012...
May 1, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29681226/traumatic-brain-injury-related-symptoms-reported-by-parents-clinical-imaging-and-host-predictors-in-children-with-impairments-in-consciousness-24-hours
#10
Emily A Evans, David Asuzu, Nathan Cook, Paul Caruso, Elise Townsend, Beth Costine-Bartell, Carla Fortes-Monteiro, Gillian Hotz, Ann-Christine Duhaime
This study examined the relationship between acute neuroimaging, host and injury factors and parent-reported traumatic brain injury-related symptoms in children with non-critical head injury at 2 weeks and 3 months after injury. Data were collected prospectively on 45 subjects aged 3-16 years old enrolled in the Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) study. Subjects had rapid recovery of mental status (Glasgow Coma Score(GCS)=15 within 24 hours), and had no clinical need for neurosurgical intervention...
April 21, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29665763/neuroimaging-radiological-interpretation-system-niris-for-acute-traumatic-brain-injury-tbi
#11
Max Wintermark, Ying Li, Victoria Y Ding, Yingding Xu, Bin Jiang, Robyn L Ball, Michael Zeineh, Alisa Gean, Pina Sanelli
To develop an outcome-based NeuroImaging Radiological Interpretation System (NIRIS) for acute traumatic brain injury (TBI) patients that would standardize the interpretation of non-contrast head CTs and consolidate imaging findings into ordinal severity categories that would inform specific patient management actions and that could be used as a clinical decision support tool. We retrospectively identified all patients transported to our emergency department by ambulance or helicopter, for whom a trauma alert was triggered per established criteria and who underwent a non-contrast head CT due to suspicion of TBI, between November 2015 and April 2016...
April 18, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29619661/midline-shift-is-unrelated-to-subjective-pupillary-reactivity-assessment-on-admission-in-moderate-and-severe-traumatic-brain-injury
#12
Basil Nourallah, David K Menon, Frederick A Zeiler
BACKGROUND: This study aims to determine the relationship between pupillary reactivity, midline shift and basal cistern effacement on brain computed tomography (CT) in moderate-to-severe traumatic brain injury (TBI). All are important diagnostic and prognostic measures, but their relationship is unclear. METHODS: A total of 204 patients with moderate-to-severe TBI, documented pupillary reactivity, and archived neuroimaging were included. Extent of midline shift and basal cistern effacement were extracted from admission brain CT...
April 4, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/29573026/neural-correlates-of-reduced-depressive-symptoms-following-cognitive-training-for-chronic-traumatic-brain-injury
#13
Kihwan Han, David Martinez, Sandra B Chapman, Daniel C Krawczyk
Depression is the most frequent comorbid psychiatric condition among individuals with traumatic brain injury (TBI). Yet, little is known about changes in the brain associated with reduced depressive symptoms following rehabilitation for TBI. We identified whether cognitive training alleviates comorbid depressive symptoms in chronic TBI (>6 months post-injury) as a secondary effect. Further, we elucidated neural correlates of alleviated depressive symptoms following cognitive training. A total of seventy-nine individuals with chronic TBI (53 depressed and 26 non-depressed individuals, measured using the Beck Depressive Inventory [BDI]), underwent either strategy- or information-based cognitive training in a small group for 8 weeks...
March 23, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29488436/neuroimaging-of-the-injured-pediatric-brain-methods-and-new-lessons
#14
Emily L Dennis, Talin Babikian, Christopher C Giza, Paul M Thompson, Robert F Asarnow
Traumatic brain injury (TBI) is a significant public health problem in the United States, especially for children and adolescents. Current epidemiological data estimate over 600,000 patients younger than 20 years are treated for TBI in emergency rooms annually. While many patients experience a full recovery, for others there can be long-lasting cognitive, neurological, psychological, and behavioral disruptions. TBI in youth can disrupt ongoing brain development and create added family stress during a formative period...
February 1, 2018: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://www.readbyqxmd.com/read/29487565/luteinizing-hormone-and-testosterone-levels-during-acute-phase-of-severe-traumatic-brain-injury-prognostic-implications-for-adult-male-patients
#15
Alexandre Hohl, Fernando Areas Zanela, Gabriela Ghisi, Marcelo Fernando Ronsoni, Alexandre Paim Diaz, Marcelo Liborio Schwarzbold, Alcir Luiz Dafre, Benjamin Reddi, Kátia Lin, Felipe Dal Pizzol, Roger Walz
Traumatic brain injury (TBI) is a worldwide core public health problem affecting mostly young male subjects. An alarming increase in incidence has turned TBI into a leading cause of morbidity and mortality in young adults as well as a tremendous resource burden on the health and welfare sector. Hormone dysfunction is highly prevalent during the acute phase of severe TBI. In particular, investigation of the luteinizing hormone (LH) and testosterone levels during the acute phase of severe TBI in male has identified a high incidence of low testosterone levels in male patients (36...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29433912/factors-influencing-emergency-department-care-of-young-children-at-risk-for-clinically-important-traumatic-brain-injury
#16
Tara Rhine, Shari L Wade, Nanhua Zhang, Huaiyu Zang, Stephanie Kennebeck, Lynn Babcock
OBJECTIVES: Care decisions for young children presenting to the emergency department (ED) with head injury are often challenging (e.g. whether to obtain neuroimaging). We sought to identify factors associated with acute management of children at-risk for clinically important traumatic brain injury (ciTBI) and describe symptom management. METHODS: Observational evaluation of children, ages 0-4years, presenting to a pediatric ED following minor head injury. Children with ≥1 risk element per the Pediatric Emergency Care Academic Research Network's decision rule were deemed "at-risk" for ciTBI...
January 31, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29404847/human-brain-modeling-with-its-anatomical-structure-and-realistic-material-properties-for-brain-injury-prediction
#17
Noritoshi Atsumi, Yuko Nakahira, Eiichi Tanaka, Masami Iwamoto
Impairments of executive brain function after traumatic brain injury (TBI) due to head impacts in traffic accidents need to be obviated. Finite element (FE) analyses with a human brain model facilitate understanding of the TBI mechanisms. However, conventional brain FE models do not suitably describe the anatomical structure in the deep brain, which is a critical region for executive brain function, and the material properties of brain parenchyma. In this study, for better TBI prediction, a novel brain FE model with anatomical structure in the deep brain was developed...
May 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29385016/fatigue-is-associated-with-global-and-regional-thalamic-morphometry-in-veterans-with-a-history-of-mild-traumatic-brain-injury
#18
Alexandra L Clark, Scott F Sorg, Kelsey Holiday, Erin D Bigler, Katherine J Bangen, Nicole D Evangelista, Mark W Bondi, Dawn M Schiehser, Lisa Delano-Wood
OBJECTIVE: Fatigue is a complex, multidimensional phenomenon that commonly occurs following traumatic brain injury (TBI). The thalamus-a structure vulnerable to both primary and secondary injuries in TBI-is thought to play a pivotal role in the manifestation of fatigue. We explored how neuroimaging markers of local and global thalamic morphometry relate to the subjective experience of fatigue post-TBI. METHODS: Sixty-three Veterans with a history of mild TBI underwent structural magnetic resonance imaging and completed questionnaires related to fatigue and psychiatric symptoms...
January 30, 2018: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/29285732/emerging-approaches-to-neurocircuits-in-ptsd-and-tbi-imaging-the-interplay-of-neural-and-emotional-trauma
#19
Andrea D Spadoni, Mingxiong Huang, Alan N Simmons
Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) commonly co-occur in general and military populations and have a number of overlapping symptoms. While research suggests that TBI is risk factor for PTSD and that PTSD may mediate TBI-related outcomes, the mechanisms of these relationships are not well understood. Neuroimaging may help elucidate patterns of neurocircuitry both specific and common to PTSD and TBI and thus help define the nature of their interaction, refine diagnostic classification, and may potentially yield opportunities for targeted treatments...
December 29, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/29262441/imaging-in-neurocritical-care-practice
#20
Craig Williamson, Larry Morgan, Joshua P Klein
The use of neuroimaging in conjunction with serial neurological examinations is a core component of modern neurocritical care practice. Although there is a growing role for other neuromonitoring techniques, the ability to quickly and accurately interpret images in the context of a patient's clinical status arguably remains the indispensable skill for neurocritical care practitioners. Due to its rapid acquisition time and excellent ability to detect intracerebral hemorrhage (ICH), cerebral edema, and signs of elevated intracranial pressure, computed tomography (CT) remains the most useful neuroimaging technique for intensive care unit (ICU) patients...
December 2017: Seminars in Respiratory and Critical Care Medicine
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