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TBI Neuroimaging

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https://www.readbyqxmd.com/read/28818271/the-vestibulocochlear-bases-for-wartime-posttraumatic-stress-disorder-manifestations
#1
T A Tigno, R A Armonda, R S Bell, M A Severson
Preliminary findings based on earlier retrospective studies of 229 wartime head injuries managed by the Walter Reed Army Medical Center (WRAMC)/National Naval Medical Center (NNMC) Neurosurgery Service during the period 2003-08 detected a threefold rise in Posttraumatic Stress Disorder (PTSD) manifestations (10.45%) among Traumatic Brain Injuries (TBI) having concomitant vestibulocochlear injuries compared to 3% for the TBI group without vestibulo-cochlear damage (VCD), prompting the authors to undertake a more focused study of the vestibulo-auditory pathway in explaining the development of posttraumatic stress disorder manifestations among the mostly Blast-exposed head-injured...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28769858/dedifferentiation-does-not-account-for-hyperconnectivity-after-traumatic-brain-injury
#2
Rachel Anne Bernier, Arnab Roy, Umesh Meyyappan Venkatesan, Emily C Grossner, Einat K Brenner, Frank Gerard Hillary
OBJECTIVE: Changes in functional network connectivity following traumatic brain injury (TBI) have received increasing attention in recent neuroimaging literature. This study sought to understand how disrupted systems adapt to injury during resting and goal-directed brain states. Hyperconnectivity has been a common finding, and dedifferentiation (or loss of segregation of networks) is one possible explanation for this finding. We hypothesized that individuals with TBI would show dedifferentiation of networks (as noted in other clinical populations) and these effects would be associated with cognitive dysfunction...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28762185/consideration-of-the-intracranial-pressure-threshold-value-for-the-initiation-of-traumatic-brain-injury-treatment-a-xenon-ct-and-perfusion-ct-study
#3
Mitsuru Honda, Ryo Ichibayashi, Ginga Suzuki, Hiroki Yokomuro, Yoshikatsu Seiki, Shigeru Sase, Taichi Kishi
BACKGROUND: Monitoring of intracranial pressure (ICP) is considered to be fundamental for the care of patients with severe traumatic brain injury (TBI) and is routinely used to direct medical and surgical therapy. Accordingly, some guidelines for the management of severe TBI recommend that treatment be initiated for ICP values >20 mmHg. However, it remained to be accounted whether there is a scientific basis to this instruction. The purpose of the present study was to clarify whether the basis of ICP values >20 mmHg is appropriate...
July 31, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28758543/inconsistencies-with-screening-for-traumatic-brain-injury-in-spinal-cord-injury-across-the-continuum-of-care
#4
Seema Sikka, Angela Vrooman, Librada Callender, David Salisbury, Monica Bennett, Rita Hamilton, Simon Driver
OBJECTIVE: Explore how traumatic brain injury (TBI) is screened among spinal cord injury (SCI) patients across the continuum of care. DESIGN: Retrospective chart review Setting: Emergency department, trauma, inpatient rehabilitation Participants: 325 patients with SCI from inpatient rehabilitation facility (IRF) between March 1, 2011 and December 31, 2014 were screened. 49 eligible subjects had traumatic SCI and received care in adjoining acute care (AC) hospital...
July 31, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28758146/effects-of-traumatic-brain-injury-and-posttraumatic-stress-disorder-on-development-of-alzheimer-s-disease-in-vietnam-veterans-using-the-alzheimer-s-disease-neuroimaging-initiative-preliminary-report
#5
Michael W Weiner, Danielle Harvey, Jacqueline Hayes, Susan M Landau, Paul S Aisen, Ronald C Petersen, Duygu Tosun, Dallas P Veitch, Clifford R Jack, Charles Decarli, Andrew J Saykin, Jordan Grafman, Thomas C Neylanthe
INTRODUCTION: Traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) have previously been reported to be associated with increased risk of Alzheimer's disease (AD). We are using biomarkers to study Vietnam Veterans with/without mild cognitive impairment with a history of at least one TBI and/or ongoing PTSD to determine whether these contribute to the development of AD. METHODS: Potential subjects identified by Veterans Administration records underwent an initial telephone screen...
June 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/28757598/selective-serotonin-reuptake-inhibitors-for-treating-neurocognitive-and-neuropsychiatric-disorders-following-traumatic-brain-injury-an-evaluation-of-current-evidence
#6
REVIEW
John K Yue, John F Burke, Pavan S Upadhyayula, Ethan A Winkler, Hansen Deng, Caitlin K Robinson, Romain Pirracchio, Catherine G Suen, Sourabh Sharma, Adam R Ferguson, Laura B Ngwenya, Murray B Stein, Geoffrey T Manley, Phiroz E Tarapore
The prevalence of neuropsychiatric disorders following traumatic brain injury (TBI) is 20%-50%, and disorders of mood and cognition may remain even after recovery of neurologic function is achieved. Selective serotonin reuptake inhibitors (SSRI) block the reuptake of serotonin in presynaptic cells to lead to increased serotonergic activity in the synaptic cleft, constituting first-line treatment for a variety of neurocognitive and neuropsychiatric disorders. This review investigates the utility of SSRIs in treating post-TBI disorders...
July 25, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28738126/comparing-plasma-phospho-tau-total-tau-and-phospho-tau-total-tau-ratio-as-acute-and-chronic-traumatic-brain-injury-biomarkers
#7
Richard Rubenstein, Binggong Chang, John K Yue, Allen Chiu, Ethan A Winkler, Ava M Puccio, Ramon Diaz-Arrastia, Esther L Yuh, Pratik Mukherjee, Alex B Valadka, Wayne A Gordon, David O Okonkwo, Peter Davies, Sanjeev Agarwal, Fan Lin, George Sarkis, Hamad Yadikar, Zhihui Yang, Geoffrey T Manley, Kevin K W Wang, Shelly R Cooper, Kristen Dams-O'Connor, Allison J Borrasso, Tomoo Inoue, Andrew I R Maas, David K Menon, David M Schnyer, Mary J Vassar
Importance: Annually in the United States, at least 3.5 million people seek medical attention for traumatic brain injury (TBI). The development of therapies for TBI is limited by the absence of diagnostic and prognostic biomarkers. Microtubule-associated protein tau is an axonal phosphoprotein. To date, the presence of the hypophosphorylated tau protein (P-tau) in plasma from patients with acute TBI and chronic TBI has not been investigated. Objective: To examine the associations between plasma P-tau and total-tau (T-tau) levels and injury presence, severity, type of pathoanatomic lesion (neuroimaging), and patient outcomes in acute and chronic TBI...
July 24, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28689050/self-reported-traumatic-brain-injury-and-in-vivo-measure-of-ad-vulnerable-cortical-thickness-and-ad-related-biomarkers-in-the-adni-cohort
#8
Ming-Liang Wang, Xiao-Er Wei, Meng-Meng Yu, Peng-Yang Li, Wen-Bin Li
In this study, we aimed to investigate whether self-reported mild traumatic brain injury (mTBI) was associated with decreased AD-vulnerable cortical thickness, and to assess the relationship between AD-vulnerable cortical thickness and AD-related biomarker in the Alzheimer's Disease Neuroimaging Initiative subjects. We identified 45 self-reported mTBI subjects, who had structural MRI, 18F-AV45 PET, and cerebrospinal fluid (CSF) data. Of them, eight subjects were normal; ten were preclinical AD; seventeen were MCI due to AD; ten were AD...
August 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28638364/impact-of-neuronal-membrane-damage-on-the-local-field-potential-in-a-large-scale-simulation-of-cerebral-cortex
#9
David L Boothe, Alfred B Yu, Pawel Kudela, William S Anderson, Jean M Vettel, Piotr J Franaszczuk
Within multiscale brain dynamics, the structure-function relationship between cellular changes at a lower scale and coordinated oscillations at a higher scale is not well understood. This relationship may be particularly relevant for understanding functional impairments after a mild traumatic brain injury (mTBI) when current neuroimaging methods do not reveal morphological changes to the brain common in moderate to severe TBI such as diffuse axonal injury or gray matter lesions. Here, we created a physiology-based model of cerebral cortex using a publicly released modeling framework (GEneral NEural SImulation System) to explore the possibility that performance deficits characteristic of blast-induced mTBI may reflect dysfunctional, local network activity influenced by microscale neuronal damage at the cellular level...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28626499/the-effects-of-blast-exposure-on-protein-deimination-in-the-brain
#10
Peter J Attilio, Michael Flora, Alaa Kamnaksh, Donald J Bradshaw, Denes Agoston, Gregory P Mueller
Oxidative stress and calcium excitotoxicity are hallmarks of traumatic brain injury (TBI). While these early disruptions may be corrected over a relatively short period of time, long-lasting consequences of TBI including impaired cognition and mood imbalances can persist for years, even in the absence of any evidence of overt injury based on neuroimaging. This investigation examined the possibility that disordered protein deimination occurs as a result of TBI and may thus contribute to the long-term pathologies of TBI...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28615277/alterations-in-the-brain-s-connectome-during-recovery-from-severe-traumatic-brain-injury-protocol-for-a-longitudinal-prospective-study
#11
Virginia Conde, Sara Hesby Andreasen, Tue Hvass Petersen, Karen Busted Larsen, Karine Madsen, Kasper Winther Andersen, Irina Akopian, Kristoffer Hougaard Madsen, Christian Pilebæk Hansen, Ingrid Poulsen, Lars Peter Kammersgaard, Hartwig Roman Siebner
INTRODUCTION: Traumatic brain injury (TBI) is considered one of the most pervasive causes of disability in people under the age of 45. TBI often results in disorders of consciousness, and clinical assessment of the state of consciousness in these patients is challenging due to the lack of behavioural responsiveness. Functional neuroimaging offers a means to assess these patients without the need for behavioural signs, indicating that brain connectivity plays a major role in consciousness emergence and maintenance...
June 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28538329/perioperative-care-for-pediatric-patients-with-penetrating-brain-injury-a-review
#12
Marco Mikhael, Elizabeth Frost, Maria Cristancho
Traumatic brain injury (TBI) continues to be the leading cause of death and acquired disability in young children and adolescents, due to blunt or penetrating trauma, the latter being less common but more lethal. Penetrating brain injury (PBI) has not been studied extensively, mainly reported as case reports or case series, due to the assumption that both types of brain injury have common pathophysiology and consequently common management. However, recommendations and guidelines for the management of PBI differ from those of blunt TBI in regards to neuroimaging, intracranial pressure (ICP) monitoring, and surgical management including those pertaining to vascular injury...
May 19, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28390522/research-frontiers-in-traumatic-brain-injury-defining-the-injury
#13
REVIEW
Andrew J Gardner, Shirley L Shih, Elizabeth V Adamov, Ross D Zafonte
With the continued advancement in technology, such as increasingly sophisticated neuroimaging parameters, and the ongoing development of various scientific fields, like serum and blood biomarkers, genetics, and physiology, traumatic brain injury (TBI) research is a dynamic field of study. TBI remains a significant public health concern and research has continued to grow exponentially over the past decade. This review provides an overview of the frontiers of TBI research, from sports concussion to severe TBI, from acute and subacute injury to long-term/chronic outcomes, from assessment and management to prognosis, specifically examining recent neuroimaging, biomarkers, genetics, and physiologic studies...
May 2017: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/28381654/disorder-of-executive-function-of-the-brain-after-head-injury-and-mild-traumatic-brain-injury-neuroimaging-and-diagnostic-criteria-for-implementation-of-administrative-support-in-japan
#14
Jun Shinoda, Yoshitaka Asano
The diagnotic criteria for disorder of the executive function of the brain (DEFB) as a syndrome of sequela were administratively established (ad-DEFB) in Japan in 2006 to support disabled patients whose impairment, limited to cognition (memory, attention, execution, and behavior), emerges after organic brain injuries regardless of physical deficits. However, some patients suffering from traumatic brain injury (TBI) have been excluded from receiving medico-social services. In particular, this tendency is more prominent in patients with mild TBI because no lesions are apparent on conventional computed tomography (CT) or magnetic resonance imaging (MRI) in the chronic phase...
May 15, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28373856/investigating-microstructural-abnormalities-and-neurocognition-in-sub-acute-and-chronic-traumatic-brain-injury-patients-with-normal-appearing-white-matter-a-preliminary-diffusion-tensor-imaging-study
#15
Eyesha Hashim, Eduardo Caverzasi, Nico Papinutto, Caroline E Lewis, Ruiwei Jing, Onella Charles, Shudong Zhang, Amy Lin, Simon J Graham, Tom A Schweizer, Aditya Bharatha, Michael D Cusimano
For a significant percentage of subjects, with chronic traumatic brain injury (TBI), who report persisting cognitive impairment and functional loss, the diagnosis is often impeded by the fact that routine neuroimaging often does not reveal any abnormalities. In this paper, we used diffusion tensor imaging (DTI) to investigate the apparently normal white matter (as assessed by routine magnetic resonance imaging) in the brains of 19 subjects with sub-acute (9) and chronic (10) TBI. We also assessed memory, executive function, and visual-motor coordination in these subjects...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28363253/the-traumatic-brain-injury-endpoints-development-ted-initiative-progress-on-a-public-private-regulatory-collaboration-to-accelerate-diagnosis-and-treatment-of-traumatic-brain-injury
#16
Geoffrey T Manley, Christine L MacDonald, Amy Markowitz, Diane Stephenson, Ann Robbins, Raquel C Gardner, Ethan A Winkler, Yelena Bodien, Sabrina Taylor, John K Yue, Lakshmi Kannan, Allison Kumar, Michael McCrea, Kevin K W Wang
The Traumatic Brain Injury Endpoints Development (TED) Initiative is a 5-year, Department of Defense (DoD) funded project that is working toward the ultimate goal of developing better designed clinical trials, leading to more precise diagnosis, and effective treatments for traumatic brain injury (TBI). TED is comprised of leading academic clinician-scientists, along with innovative industry leaders in biotechnology and imaging technology, patient advocacy organizations, and philanthropists, working collaboratively with regulatory authorities, specifically the US Food and Drug Administration (FDA)...
March 31, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28355230/a-blood-based-biomarker-panel-to-risk-stratify-mild-traumatic-brain-injury
#17
Richa Sharma, Alexandra Rosenberg, Ellen R Bennett, Daniel T Laskowitz, Shawn K Acheson
Mild traumatic brain injury (TBI) accounts for the vast majority of the nearly two million brain injuries suffered in the United States each year. Mild TBI is commonly classified as complicated (radiographic evidence of intracranial injury) or uncomplicated (radiographically negative). Such a distinction is important because it helps to determine the need for further neuroimaging, potential admission, or neurosurgical intervention. Unfortunately, imaging modalities such as computed tomography (CT) and magnetic resonance imaging (MRI) are costly and not without some risk...
2017: PloS One
https://www.readbyqxmd.com/read/28337475/age-at-injury-is-associated-with-the-long-term-cognitive-outcome-of-traumatic-brain-injuries
#18
Wei Li, Shannon L Risacher, Thomas W McAllister, Andrew J Saykin
INTRODUCTION: The association between age at injury (AAI) and long-term cognitive outcome of traumatic brain injuries (TBI) is debatable. METHODS: Eligible participants with a history of TBI from Alzheimer's Disease Neuroimaging Initiative were divided into a childhood TBI (cTBI) group (the AAI ≤ 21 years old) and an adult TBI (aTBI) group (the AAI > 21 years old). RESULTS: The cTBI group has a higher Everyday Cognition total score than the aTBI group...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28316319/epileptic-spasms-in-paediatric-post-traumatic-epilepsy-at-a-tertiary-referral-centre
#19
Jun T Park, Harry T Chugani
To recognize epileptic spasms (ES) as a seizure type after traumatic brain injury (TBI), accidental or non-accidental, in infants and children. In the process, we aim to gain some insight into the mechanisms of epileptogenesis in ES. A retrospective electronic chart review was performed at the Children's Hospital of Michigan from 2002 to 2012. Electronic charts of 321 patients were reviewed for evidence of post-traumatic epilepsy. Various clinical variables were collected including age at TBI, mechanism of trauma, severity of brain injury, electroencephalography/neuroimaging data, and seizure semiology...
March 1, 2017: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/28281095/a-national-study-on-the-effects-of-concussion-in-collegiate-athletes-and-us-military-service-academy-members-the-ncaa-dod-concussion-assessment-research-and-education-care-consortium-structure-and-methods
#20
Steven P Broglio, Michael McCrea, Thomas McAllister, Jaroslaw Harezlak, Barry Katz, Dallas Hack, Brian Hainline
BACKGROUND: The natural history of mild traumatic brain injury (TBI) or concussion remains poorly defined and no objective biomarker of physiological recovery exists for clinical use. The National Collegiate Athletic Association (NCAA) and the US Department of Defense (DoD) established the Concussion Assessment, Research and Education (CARE) Consortium to study the natural history of clinical and neurobiological recovery after concussion in the service of improved injury prevention, safety and medical care for student-athletes and military personnel...
July 2017: Sports Medicine
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