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Prescription drug abuse misuse

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https://www.readbyqxmd.com/read/27898133/opioid-misuse-abuse-and-quality-persistent-pain-management-in-older-adults
#1
Yu-Ping Chang, Peggy Compton
The United States is amid an epidemic of prescription opioid drug abuse, bringing with it not only high rates of overdose, but growing rates of heroin abuse and addiction. Liberal opioid drug prescribing on the part of well-meaning clinicians has in part fueled this epidemic, being correlated to opioid death and addiction treatment admission rates. Misuse and abuse of prescription opioid drugs is greatest among young adults (ages 18 to 25); however, the fastest growing age group for opioid drug misuse/abuse is older (ages 50 to 64)...
December 1, 2016: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/27897465/predicting-young-adults-risk-for-engaging-in-prescription-drug-misuse-in-daily-life-from-individual-partner-and-relationship-factors
#2
Lauren M Papp, Chrystyna D Kouros
BACKGROUND: Mounting evidence based on retrospective and global assessments has established associations between prescription drug misuse and illicit drug use, alcohol abuse, mental health problems, risky sexual behaviors, and overdose deaths. However, there is a notable absence of identified risk and protective factors for an individual's likelihood of engaging in misuse in real-world environments. METHODS: Using an experience sampling approach, we collected repeated moments of young adults' (n = 95 participants drawn from 49 romantic couples) prescription drug misuse instances in daily life, and tested multiple factors associated with the misuse...
November 29, 2016: Substance Abuse
https://www.readbyqxmd.com/read/27848217/pregabalin-for-the-treatment-of-drug-and-alcohol-withdrawal-symptoms-a-comprehensive-review
#3
REVIEW
Rainer Freynhagen, Miroslav Backonja, Stephan Schug, Gavin Lyndon, Bruce Parsons, Stephen Watt, Regina Behar
Treatments for physical dependence and associated withdrawal symptoms following the abrupt discontinuation of prescription drugs (such as opioids and benzodiazepines), nicotine, alcohol, and cannabinoids are available, but there is still a need for new and more effective therapies. This review examines evidence supporting the potential use of pregabalin, an α2δ voltage-gated calcium channel subunit ligand, for the treatment of physical dependence and associated withdrawal symptoms. A literature search of the MEDLINE and Cochrane Library databases up to and including 11 December 2015 was conducted...
November 16, 2016: CNS Drugs
https://www.readbyqxmd.com/read/27816251/the-relationships-of-childhood-trauma-and-adulthood-prescription-pain-reliever-misuse-and-injection-drug-use
#4
Kelly Quinn, Lauren Boone, Joy D Scheidell, Pedro Mateu-Gelabert, Susan P McGorray, Nisha Beharie, Linda B Cottler, Maria R Khan
BACKGROUND: We examined associations between childhood trauma and adulthood prescription pain reliever misuse (PPRM) and injection drug use (IDU) in a nationally-representative U.S. sample to further understanding of factors associated with these epidemics. METHODS: National Longitudinal Study of Adolescent to Adult Health data (N=12,288) yielded nine childhood traumas: neglect; emotional, physical, sexual abuse; parental incarceration and binge drinking; witnessed, threatened with, and experienced violence...
October 4, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27802876/something-for-pain-responsible-opioid-use-in-emergency-medicine
#5
Reuben J Strayer, Sergey M Motov, Lewis S Nelson
The United States is currently experiencing a public health crisis of opioid addiction, which has its genesis in an industry marketing effort that successfully encouraged clinicians to prescribe opioids liberally, and asserted the safety of prescribing opioids for chronic non-cancer pain, despite a preponderance of evidence demonstrating the risks of dependence and misuse. The resulting rise in opioid use has pushed drug overdose deaths in front of motor vehicle collisions to become the leading cause of accidental death in the country...
October 24, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27796624/violence-trauma-mental-health-and-substance-use-among-homeless-youth-juggalos
#6
Robin Petering, Harmony Rhoades, Hailey Winetrobe, David Dent, Eric Rice
Insane Clown Posse is a musical duo whose fans are known as Juggalos. Many homeless youths (HY) identify as Juggalos, most likely because the group's music embraces poverty and being an outsider in mainstream society. Juggalos are stereotyped as being violent, undereducated, poor, racist, crime-committing youth, and in 2011 the FBI officially labeled Juggalos as a gang. However, little is known about the intersection of HY and Juggalos. A convenience sample of Los Angeles-area, drop-in service-seeking HY completed a self-administered questionnaire (N = 495)...
October 28, 2016: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/27782769/prescription-opioid-abuse-and-misuse-gap-between-primary-care-investigator-assessment-and-actual-extent-of-these-behaviors-among-patients-with-chronic-pain
#7
Beatrice Setnik, Carl L Roland, Glenn C Pixton, Kenneth W Sommerville
OBJECTIVES: To compare the results of two open-label primary care-based studies that examined investigator assessment of patient risk for prescription opioid misuse, abuse, and diversion relative to patient self-reports and urine drug tests (UDTs). METHODS: Risk assessment data from two open-label, multicenter, primary care-based US studies in patients with chronic pain were compared. RESULTS: In one study (n = 1487), 54.4% of patients were at moderate, 24...
October 26, 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27720453/-new-patterns-of-substance-use-and-abuse-among-french-adolescents-a-knowledge-synthesis
#8
G Jeanne, D Purper-Ouakil, H Rigole, N Franc
AIM: There have been significant changes in adolescent consumption habits over the past fifteen years. New molecules have been synthesized, new devices created and a number of products have increased in popularity; and as a result clinicians sometimes lack information. We chose to focus on this population because of its vulnerability, as adolescents show low sensitivity to long-term outcomes of their actions and may be easily influenced by peers as regards experimentation of new drugs...
October 6, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27716575/sustained-reduction-of-diversion-and-abuse-after-introduction-of-an-abuse-deterrent-formulation-of-extended-release-oxycodone
#9
Stevan Geoffrey Severtson, Matthew S Ellis, Steven P Kurtz, Andrew Rosenblum, Theodore J Cicero, Mark W Parrino, Michael K Gilbert, Mance E Buttram, Nabarun Dasgupta, Becki BucherBartelson, Jody L Green, Richard C Dart
BACKGROUND: The development of abuse deterrent formulations is one strategy for reducing prescription opioid misuse and abuse. A putative abuse deterrent formulation of oxycodone extended release (OxyContin(®)) was introduced in 2010. Early reports demonstrated reduced abuse and diversion, however, an analysis of social media found 32 feasible methods to circumvent the abuse deterrent mechanism. We measured trends of diversion, abuse and street price of OxyContin to assess the durability of the initial reduction in abuse...
November 1, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27702963/controlled-substance-lock-in-programs-examining-an-unintended-consequence-of-a-prescription-drug-abuse-policy
#10
Andrew W Roberts, Joel F Farley, G Mark Holmes, Christine U Oramasionwu, Chris Ringwalt, Betsy Sleath, Asheley C Skinner
Controlled substance lock-in programs are garnering increased attention from payers and policy makers seeking to combat the epidemic of opioid misuse. These programs require high-risk patients to visit a single prescriber and pharmacy for coverage of controlled substance medication services. Despite high prevalence of the programs in Medicaid, we know little about their effects on patients' behavior and outcomes aside from reducing controlled substance-related claims. Our study was the first rigorous investigation of lock-in programs' effects on out-of-pocket controlled substance prescription fills, which circumvent the programs' restrictions and mitigate their potential public health benefits...
October 1, 2016: Health Affairs
https://www.readbyqxmd.com/read/27690507/prescription-stimulant-medication-misuse-where-are-we-and-where-do-we-go-from-here
#11
Lisa L Weyandt, Danielle R Oster, Marisa E Marraccini, Bergljot Gyda Gudmundsdottir, Bailey A Munro, Emma S Rathkey, Alison McCallum
Prescription stimulants, including methylphenidate (e.g., Ritalin) and amphetamine compounds (e.g., dextroamphetamine; Adderall), have been approved by the U.S. Food and Drug Administration for the treatment of attention-deficit/hyperactivity disorder (ADHD) and are classified by the United States Drug Enforcement Administration as Schedule II medications because of their high potential for abuse and dependence (Drug Enforcement Administration, U.S. Department of Justice, 2015). Despite the potential health and judicial consequences, misuse of prescription stimulants, typically defined as taking stimulants without a valid prescription, or use of stimulants other than as prescribed, has become a serious problem in the United States and abroad, especially on college campuses...
October 2016: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27651506/a-randomized-double-blind-double-dummy-placebo-controlled-intranasal-drug-liking-study-on-a-novel-abuse-deterrent-formulation-of-morphine-morphine-arer
#12
Lynn R Webster, Carmela Pantaleon, Manish S Shah, Ray DiFalco, Matthew Iverson, Michael D Smith, Eric R Kinzler, Stefan Aigner
OBJECTIVE:  Misuse and abuse of prescription opioids remains a major healthcare concern despite considerable efforts to increase public awareness. Abuse-deterrent formulations of prescription opioids are designed to reduce intentional misuse, abuse, and prescription opioid-related death. A novel extended-release (ER) formulation of morphine (Morphine ARER; MorphaBond™) resists physical manipulation and retains the drug's ER characteristics, even if attempts are made to manipulate the formulation...
September 20, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27575829/caveat-emptor-erroneous-safety-information-about-opioids-in-online-drug-information-compendia
#13
Sonia R Talwar, Amarita S Randhawa, Erica H Dankiewicz, Nancy T Crudele, J David Haddox
BACKGROUND: Healthcare professionals and consumers refer to online drug-information compendia (eg, Epocrates and WebMD) to learn about prescription medications, including opioid analgesics. With the significant risks associated with opioids, including abuse, misuse, and addiction, any of which can result in life-threatening overdose, it is important for those seeking information from online compendia to have access to current, accurate, and complete drug information to help support clinical treatment decisions...
July 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/27544943/prescription-drug-abuse-in-arkansas-an-update
#14
Casey L Penn
No abstract text is available yet for this article.
July 2016: Journal of the Arkansas Medical Society
https://www.readbyqxmd.com/read/27538503/antimicrobial-stewardship-in-paediatrics
#15
REVIEW
Nicola Principi, Susanna Esposito
BACKGROUND: Antibiotics are among the drugs most commonly prescribed to children in hospitals and communities. Unfortunately, a great number of these prescriptions are unnecessary or inappropriate. Antibiotic abuse and misuse have several negative consequences, including drug-related adverse events, the emergence of multidrug resistant bacterial pathogens, the development of Clostridium difficile infection, the negative impact on microbiota, and undertreatment risks. In this paper, the principle of and strategies for paediatric antimicrobial stewardship (AS) programs, the effects of AS interventions and the common barriers to development and implementation of AS programs are discussed...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27533391/eu-study-reveals-extent-of-prescription-drug-misuse
#16
(no author information available yet)
The first comparative study of prescription drug abuse in the European Union suggests the problem is bigger than previously thought.
August 17, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27444426/design-of-the-nida-clinical-trials-network-validation-study-of-tobacco-alcohol-prescription-medications-and-substance-use-misuse-taps-tool
#17
Li-Tzy Wu, Jennifer McNeely, Geetha A Subramaniam, Gaurav Sharma, Paul VanVeldhuisen, Robert P Schwartz
BACKGROUND: Substance use and its associated use disorders are under-detected and under-treated in primary care. There is a need for a clinically useful brief screening and assessment instrument to identify primary care patients with substance use, sub-threshold substance use disorder (SUD), and SUD to facilitate brief intervention and treatment. METHODS: We describe the design of the recently completed National Drug Abuse Treatment Clinical Trials Network's tobacco, alcohol, prescription medications, and substance use/misuse screen and brief assessment tool validation study...
September 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27435441/risk-factors-for-opioid-misuse-in-adolescents-and-young-adults-with-focus-on-oncology-setting
#18
Kelly R Peck, Jennifer Harman Ehrentraut, Doralina L Anghelescu
Prescription opioid use has increased in recent decades. Although opioids provide effective pain control, their use may be associated with the risk of misuse. Opioid misuse (OM) is prevalent among adolescents and young adults (AYAs). Opioids are necessary to treat cancer-related pain; however, oncology patients are not immune to medication misuse. Research examining OM among AYAs with cancer is scarce. This article examines the risk factors described in the general adult and adolescent medication abuse literature and aims to provide recommendations for practice in the AYA oncology population...
May 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/27353833/development-of-the-older-adult-prescription-drug-assessment-questionnaire-for-case-workers
#19
Natalie D Pope, Karen L Slovak, Jarod T Giger
Instruments assessing geriatric case managers' perceptions of prescription abuse are limited. Based on a review of current literature and pilot testing feedback, 22 items were initially assembled to form an older adult Prescription Drug Assessment Questionnaire (PDAQ). Case managers (N = 161) at an older adult agency located in a Midwestern state were surveyed using the instrument. Data were subjected to exploratory factor analysis using principal axis factoring (PAF) and Promax rotation, and Horn's parallel analysis determined the number of extracted factors...
June 26, 2016: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/27332619/state-legal-restrictions-and-prescription-opioid-use-among-disabled-adults
#20
Ellen Meara, Jill R Horwitz, Wilson Powell, Lynn McClelland, Weiping Zhou, A James O'Malley, Nancy E Morden
BACKGROUND: In response to rising rates of opioid abuse and overdose, U.S. states enacted laws to restrict the prescribing and dispensing of controlled substances. The effect of these laws on opioid use is unclear. METHODS: We tested associations between prescription-opioid receipt and state controlled-substances laws. Using Medicare administrative data for fee-for-service disabled beneficiaries 21 to 64 years of age who were alive throughout the calendar year (8...
July 7, 2016: New England Journal of Medicine
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