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Quadruple aim

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https://www.readbyqxmd.com/read/29224385/serum-glycosylation-characterization-of-osteonecrosis-of-the-femoral-head-by-mass-spectrometry
#1
Ting Song, Peng Chen, Carol Stroble, L Renee Ruhaak, Haibin Wang, Ziqi Li, Wei He, Carlito B Lebrilla
Osteonecrosis of the femoral head is a recalcitrant and paralyzing disease often discovered in the end stage at the time of diagnosis, which is often performed by physical examination and diagnostic imaging. Osteonecrosis of the femoral head is typically caused by trauma or long-term steroid use. There are over 30 million patients in the US taking steroids, and roughly 40% will develop osteonecrosis of the femoral head. However, the exact pathophysiological process is not well understood. This study aims to examine the alteration in serum glycosylation of osteonecrosis of the femoral head using the state-of-the-art analytical tools to provide more chemical data for pathophysiology research and possibly biomarker discovery...
January 1, 2017: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/29206259/nurse-educators-leading-health-care-to-the-quadruple-aim-sweet-spot
#2
EDITORIAL
Jan Boller
No abstract text is available yet for this article.
December 1, 2017: Journal of Nursing Education
https://www.readbyqxmd.com/read/29189395/augmented-quadruple-phase-contrast-media-administration-and-triphasic-scan-protocol-increases-image-quality-at-reduced-radiation-dose-during-computed-tomography-urography
#3
Charbel Saade, May Mohamad, Racha Kerek, Nadine Hamieh, Ibrahim Alsheikh Deeb, Bassam El-Achkar, Hani Tamim, Farah Abdul Razzak, Maurice Haddad, Alain S Abi-Ghanem, Fadi El-Merhi
PURPOSE: The aim of this article was to investigate the opacification of the renal vasculature and the urogenital system during computed tomography urography by using a quadruple-phase contrast media in a triphasic scan protocol. MATERIALS AND METHODS: A total of 200 patients with possible urinary tract abnormalities were equally divided between 2 protocols. Protocol A used the conventional single bolus and quadruple-phase scan protocol (pre, arterial, venous, and delayed), retrospectively...
November 16, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29187412/protocol-for-the-melatools-skin-self-monitoring-trial-a-phase-ii-randomised-controlled-trial-of-an-intervention-for-primary-care-patients-at-higher-risk-of-melanoma
#4
Katie Mills, Jon Emery, Rebecca Lantaff, Michael Radford, Merel Pannebakker, Per Hall, Nigel Burrows, Kate Williams, Catherine L Saunders, Peter Murchie, Fiona M Walter
INTRODUCTION: Melanoma is the fifth most common cancer in the UK. Incidence rates have quadrupled over the last 30 years and continue to rise, especially among younger people. As routine screening of the general population is not currently recommended in the UK, a focus on secondary prevention through early detection and prompt treatment in individuals at increased risk of melanoma could make an important contribution to improve melanoma outcomes. This paper describes the protocol for a phase II, multisite, randomised controlled trial, in the primary care setting, for patients at increased risk of melanoma...
November 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/29161792/-trend-in-the-eradication-rates-of-helicobacter-pylori-infection-over-the-last-10-years-in-west-gyeonggi-do-korea-a-single-center-experience
#5
Jong Seol Park, Ji Eun Park, Byoung Soo Oh, Byung Wook Yoon, Hyun Ki Kim, Jae Won Lee, Nam Ho Kim, Won Seok Cho, Young Sik Woo, Jaehoon Jahng, Yong Sung Kim
Background/Aims: The eradication rate of Helicobacter pylori (H. pylori) has been decreasing recently in Korea due to antibiotics resistance. The aim of this study was to investigate the trend of eradication rate and clinical factors affecting the eradication rate of H. pylori in the last 10 years in west Gyeonggi-do, Korea. Methods: The trends of eradication rate of H. pylori, gender, age, concomitant mediations, and clinical factors were retrospectively evaluated in patients with H...
November 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29144156/upmc-prescription-for-wellness-a-quality-improvement-case-study-for-supporting-patient-engagement-and-health-behavior-change
#6
Rebecca J Maners, Eric Bakow, Michael D Parkinson, Gary S Fischer, Geoffrey R Camp
Addressing patient health and care behaviors that underlie much of chronic disease continues to challenge providers, medical practices, health systems, and insurers. Improving health and care as described by the Quadruple Aim requires innovation at the front lines of clinical care: the doctor-patient interaction and office practice. This article describes the use of Lean Six Sigma in a quality improvement (QI) effort to design an effective and scalable method for physicians to prescribe health coaching for healthy behaviors in a primary care medical home within a large integrated delivery and financing system...
November 1, 2017: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/29138611/volunteer-patients-and-small-groups-contribute-to-abdominal-examination-s-success
#7
Helen M Shields, Nielsen Q Fernandez-Becker, Sarah N Flier, Byron P Vaughn, Melissa H Tukey, Stephen R Pelletier, Douglas A Horst
Background: Prior to 2007, we taught the abdominal examination in a hospital based group to 40 students, at one hospital. We used volunteer patients, small groups, repetition, and required faculty development sessions. In 2007, our medical school changed its "Introduction to Physical Examination" session so that the entire class was to be taught in a geographically central session. Our hospital was selected to lead the abdominal examination portion of the session. Aim: Our aim was to answer three questions...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/29131124/comparison-of-helicobacter-pylori-eradication-rates-of-2-week-levofloxacin-containing-triple-therapy-levofloxacin-containing-bismuth-quadruple-therapy-and-standard-bismuth-quadruple-therapy-as-a-first-line-regimen
#8
Evrim Kahramanoğlu Aksoy, Ferdane Pirinçci Sapmaz, Zeynep Göktaş, Metin Uzman, Yaşar Nazlıgül
OBJECTIVE: The aim of this study was to compare the efficacy and safety of 2-week levofloxacin containing triple therapy, levofloxacin containing bismuth quadruple therapy and standard bismuth containing quadruple therapy as a first-line regimen for eradication of Helicobacter pylori (H pylori). METHODS: A total of 329 patients with H pylori infection were randomly divided into three groups to receive: a) levofloxacin containing bismuth quadruple therapy, RBAL (rabeprazole 20 mg b...
November 3, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29129474/-screening-program-for-tuberculosis-among-international-exchange-students-in-the-department-of-is%C3%A3-re
#9
M-V Albahary, F Blanc-Jouvan, C Recule, C Dubey, P Pavese
INTRODUCTION: France is a low-incidence country for tuberculosis (TB). Consequently screening is focused on high-risk populations, in particular migrants. The aim of this study was to evaluate the epidemiology of TB among international exchange students in the Department of Isère and the screening programs used. METHODS: We carried out an organizational audit based on interviews with physicians involved in the management of TB in Isère. We conducted a retrospective descriptive study based on a case series of foreign students treated for TB from 2003 to 2013 inclusively...
November 9, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29101042/magnitude-and-pattern-of-placebo-response-in-clinical-trials-of-antiepileptic-medications-data-from-the-food-and-drug-administration-1996-2016
#10
Arif Khan, Kaysee Fahl Mar, Joshua Schilling, Walter A Brown
This study aimed to replicate and extend the findings of previous investigations looking at treatment responses in antiepileptic clinical trials over time and to examine the effects of subject age and duration of treatment. To address the potential biases of published literature, we examined the reported data from 14 investigational antiepileptic drugs (AEDs) (34 trials, 59 treatment arms, 10,783 patients) reviewed and approved by the US FDA (1996-2016). For each treatment arm, we recorded drug and placebo response (percent reduction in seizure frequency), calculated effect sizes, and examined these measures over time...
October 31, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29094477/rescue-therapy-with-bismuth-quadruple-regimen-in-patients-with-helicobacter-pylori-resistant-strains
#11
Giulia Fiorini, Ilaria Maria Saracino, Angelo Zullo, Luigi Gatta, Matteo Pavoni, Dino Vaira
BACKGROUND: Bismuth quadruple therapy (BQT) is the recommended rescue therapy for Helicobacter pylori (H. pylori) infection. This study aimed to assess the efficacy and safety of a 10-day BQT regimen in patients who failed previous therapies and were infected with multiresistant H. pylori strains MATERIALS AND METHODS: Helicobacter pylori-infected patients underwent endoscopy, culture, and susceptibility test for clarithromycin, metronidazole, and levofloxacin. Treatment with three-in-one capsule (Pylera®) four times daily and esomeprazole 20 mg twice daily for 10 days was administered...
November 1, 2017: Helicobacter
https://www.readbyqxmd.com/read/29076008/cumulative-helicobacter-pylori-eradication-rates-by-adopting-first-and-second-line-regimens-proposed-by-the-maastricht-iv-consensus-in-obese-patients-undergoing-gastric-bypass-surgery
#12
Rute M Cerqueira, M Correia, H Vilar, M C Manso
AIMS AND METHODS: Our aim was to assess, in obese patients undergoing Roux-en-Y gastric bypass (RYGB) surgery, the cumulative Helicobacter pylori (HP) eradication rates by adopting Maastricht IV guidelines in areas of high clarithromycin resistance rates (CLT)-14 days concomitant first-line therapy with proton-pump inhibitor (PPI) bid, CLT 500 mg bid, metronidazole (MTZ) 500 bid, and amoxicillin (AMX) 1000 mg bid and 14 days second-line therapy with PPI bid, AMX 1000 mg bid and levofloxacin (LVF) 500 mg od...
October 26, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29022423/combination-antiplatelet-treatment-in-coronary-artery-disease-patients-a-necessary-evil-or-an-overzealous-practice
#13
Dimitrios Alexopoulos, Konstantinos Katogiannis, Danai Sfantou, John Lekakis
In seeking to improve care in coronary artery disease patients, further platelet inhibition has been occasionally applied beyond that provided by aspirin and a P2Y12 receptor antagonist. This review aims to offer insights about the rationale, the efficacy and safety of combination antiplatelet therapy, involving three or more agents. Overall, the use of glycoprotein (GP) IIb/IIIa inhibitors did not significantly modify the treatment effect of different antiplatelet strategies, including double vs standard clopidogrel, prasugrel vs clopidogrel, ticagrelor vs clopidogrel, cangrelor vs clopidogrel, and vorapaxar vs placebo...
October 12, 2017: Platelets
https://www.readbyqxmd.com/read/28967438/identification-of-specific-gait-patterns-in-patients-with-cerebellar-ataxia-spastic-paraplegia-and-parkinson-s-disease-a-non-hierarchical-cluster-analysis
#14
Mariano Serrao, Giorgia Chini, Matteo Bergantino, Diego Sarnari, Carlo Casali, Carmela Conte, Alberto Ranavolo, Christian Marcotulli, Martina Rinaldi, Gianluca Coppola, Fabiano Bini, Francesco Pierelli, Franco Marinozzi
Patients with degenerative neurological diseases such as cerebellar ataxia, spastic paraplegia, and Parkinson's disease often display progressive gait function decline that inexorably impacts their autonomy and quality of life. Therefore, considering the related social and economic costs, one of the most important areas of intervention in neurorehabilitation should be the treatment of gait abnormalities. This study aims to determine whether an entire dataset of gait parameters recorded in patients with degenerative neurological diseases can be clustered into homogeneous groups distinct from each other and from healthy subjects...
September 26, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28957341/efficacy-and-safety-of-sequential-versus-quadruple-therapy-as-second-line-treatment-for-helicobacter-pylori-infection-a-randomized-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
Daniela Munteanu, Ohad Etzion, Gil Ben-Yakov, Daniel Halperin, Leslie Eidelman, Doron Schwartz, Victor Novack, Naim Abufreha, Pavel Krugliak, Alexander Rozenthal, Nava Gaspar, Alexander Moshkalo, Vitaly Dizingof, Alexander Fich
BACKGROUND AND AIMS: Quadruple therapy is recommended as second-line treatment for Helicobacter pylori eradication failure. However, high cost, multiple side effects, and low adherence rates are major drawbacks to its routine use. Our aim was to compare the efficacy and safety of sequential versus quadruple regimens as second line treatment for persistent Helicobacter pylori infection. METHODS: Prospective, randomized, open label trial was conducted at a large academic, tertiary care center in Israel...
2017: PloS One
https://www.readbyqxmd.com/read/28956286/all-cause-and-drug-related-medical-events-associated-with-overuse-of-gabapentin-and-or-opioid-medications-a-retrospective-cohort-analysis-of-a-commercially-insured-us-population
#16
Alyssa M Peckham, Kathleen A Fairman, David A Sclar
INTRODUCTION: Overuse of gabapentin and/or opioids occurs in a small percentage of patients at > 3-fold labeled dosages. Gabapentin may potentiate opioid effects. OBJECTIVE: The aim was to assess patient harm, defined as use of inpatient hospital (IPH) or emergency department (ED) services, associated with overuse of gabapentin with or without concomitant overuse of opioids. DATA SOURCE: Data were sourced from the Truven Health MarketScan(®) Commercial Claims and Encounters database, for the years 2013-2015...
September 27, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28937021/optimized-high-dose-amoxicillin-proton-pump-inhibitor-dual-therapies-fail-to-achieve-high-cure-rates-in-china
#17
Jia-Li Hu, Jun Yang, Yin-Bin Zhou, Ping Li, Ran Han, Dian-Chun Fang
Background\Aim: Quadruple daily administration of proton-pump inhibitor (PPI) therapy achieves potent acid inhibition, and combined with amoxicillin, with its pharmacodynamic and pharmacokinetic characteristics, may be efficient for Helicobacter pylori eradication. We compared the efficacy of two optimized high-dose dual therapies with a bismuth-containing quadruple regimen for treating H. pylori infection. Rabeprazole dosages for H. pylori eradication were also evaluated. PATIENTS AND METHODS: Treatment-naive and H...
September 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28926321/evaluation-of-platelet-activation-during-storage-in-leukocyte-depleted-platelet-concentrates
#18
Miodrag Vucic, Zoran Stanojkovic, Ana Antic, Jelana Vucic, Voja Pavlovic
Structural and functional changes in platelets during storage can lead to the loss of platelet reactivity and response. Our aim was to evaluate leukocyte-depleted platelet concentrates, obtained by in-line filtration on storage days 0, 3 and 5. In non-filtered platelet concentrates (NF-PC) group, 180 whole blood units were collected with quadruple blood bags and then compared to another group of 180 whole blood units (leukocyte-depleted platelet concentrates [LD-PC]), collected in Imuflex Whole Blood Filter Saving Platelets (WB-SP) bags with an integrated leukoreduction filter, with regard to the platelet quality and characteristics...
September 19, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28922716/quaternary-ammonium-groups-modified-starch-microspheres-for-instant-hemorrhage-control
#19
Fangping Chen, Xiaoyan Cao, Junxia Yu, Huantong Su, Shuda Wei, Hua Hong, Changsheng Liu
Instant rapid hemostasis is crucial not only for decreasing mortality in these conditions, but also for optimal recovery. The hemostatic agents on the market suffer from inefficiency hemostasis, nondegradability, high cost and potential safety issues. It is necessary to develop a hemostatic agent with rapid hemostatic performance, potent biodegradation and improved biocompatibility. The aim of this work was to develop a novel type of cationic modified starch microspheres (CS) and investigate its hemostatic performance...
August 24, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28922433/bismuth-based-quadruple-therapy-following-h-pylori-eradication-failures-a-multicenter-study-in-clinical-practice
#20
Angelo Zullo, Vincenzo De Francesco, Annamaria Bellesia, Roberto Vassallo, Audenzio D'Angelo, Giuseppe Scaccianoce, Rodolfo Sacco, Giampaolo Bresci, Annarita Eramo, Anna Tanzilli, Lorenzo Ridola, Domenico Alvaro, Claudio Londoni, Gianfranco Brambilla, Raffaele Manta, Agostino Di Ciaula, Piero Portincasa
BACKGROUND AND AIMS: Helicobacter pylori (H. pylori) eradication in patients who failed one or more therapeutic attempts remains challenging. This study aimed to assess the efficacy of three-in-one capsules bismuth-based quadruple therapy (Pylera®) in these patients managed in clinical practice. METHODS: This was a prospective, open-label, multicenter study enrolling consecutive, adult patients with persistent H. pylori infection following at least one standard therapy...
September 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
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