An-Jing Ren, Chunchun Wei, Ya-Jin Liu, Mengna Liu, Ping Wang, Juan Fan, Kai Wang, Sha Zhang, Zhenbang Qin, Qiu-Xiao Ren, Yanjun Zheng, Yu-Xia Chen, Zhifang Xie, Ling Gao, Yi Zhu, Youyi Zhang, Huang-Tian Yang, Weiping J Zhang
BACKGROUND: Intracellular Ca2+ cycling determines myocardial contraction and relaxation in response to physiological demands. SERCA2a (sarcoplasmic/endoplasmic reticulum Ca2+ -ATPase 2a) is responsible for the sequestration of cytosolic Ca2+ into intracellular stores during cardiac relaxation, and its activity is reversibly inhibited by PLN (phospholamban). However, the regulatory hierarchy of SERCA2a activity remains unclear. METHODS: Cardiomyocyte-specific ZBTB20 knockout mice were generated by crossing ZBTB20 flox mice with Myh6 -Cre mice...
January 3, 2024: Circulation Research