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https://www.readbyqxmd.com/read/28198725/adult-pneumococcal-vaccination-advances-impact-and-unmet-needs
#1
Ricardo J José, Jeremy S Brown
PURPOSE OF REVIEW: Preventing pneumonia in the elderly and study participants individuals with comorbidities is an unmet clinical need. Streptococcus pneumoniae is the commonest bacterial cause of pneumonia, and we summarize recent findings regarding current S. pneumoniae vaccines, and debate their efficacy and cost-effectiveness in risk groups. We also discuss potential future vaccine strategies such as protein antigen vaccines. RECENT FINDINGS: Current vaccination with pneumococcal polysaccharide vaccine does not prevent S...
February 13, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28196060/angiographic-subtypes-of-polypoidal-choroidal-vasculopathy-in-taiwan-a-prospective-multicenter-study
#2
Ling Yeung, Chien-Neng Kuo, An-Ning Chao, Kuan-Jen Chen, Wei-Chi Wu, Chien-Hsiung Lai, Nan-Kai Wang, Yih-Shiou Hwang, Ching-Lung Chen, Chi-Chun Lai
PURPOSE: To determine the incidence and clinical characteristics of angiographic subtypes of polypoidal choroidal vasculopathy (PCV). METHODS: It is a prospective, multicenter, cross-sectional study. Patients with newly diagnosed exudative macular degeneration are classified into PCV, age-related macular degeneration (AMD), and retinal angiomatous proliferation. Polypoidal choroidal vasculopathy is further classified into two subtypes depending on the presence (Type 1: polypoidal choroidal neovascularization) or absence (Type 2: typical PCV) of feeder vessels on indocyanine green angiography...
February 10, 2017: Retina
https://www.readbyqxmd.com/read/28195615/quantitative-analysis-of-en-face-spectral-domain-optical-coherence-tomography-imaging-in-polypoidal-choroidal-vasculopathy
#3
Joseph M Simonett, Errol W Chan, Jonathan Chou, Dimitra Skondra, Daniel Colon, Caroline K Chee, Gopal Lingam, Amani A Fawzi
BACKGROUND AND OBJECTIVE: Spectral-domain optical coherence tomography (SD-OCT) imaging can be used to visualize polypoidal choroidal vasculopathy (PCV) lesions in the en face plane. Here, the authors describe a novel lesion quantification technique and compare PCV lesion area measurements and morphology before and after anti-vascular endothelial growth factor (VEGF) treatment. PATIENTS AND METHODS: Volumetric SD-OCT scans in eyes with PCV before and after induction anti-VEGF therapy were retrospectively analyzed...
February 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28194625/trypanosomiasis-challenge-estimation-using-the-diminazene-aceturate-berenil-index-in-zebu-in-gabon
#4
Brieuc G A Cossic, Brice Adjahoutonon, Pierre Gloaguen, Gui Lov Dibanganga, Gael Maganga, Pascal Leroy, Ewan T MacLeod, Kim Picozzi
A longitudinal study was conducted within a cattle ranch in Gabon to determine the diminazene aceturate (Berenil) index (DAI) in a group of Zebu, raised under low tsetse density; this measure providing an assessment of trypanosomiasis risk. The objective was to evaluate the trypanosomiasis pressure thus informing trypanosomiasis control methods and cattle management. Twenty female adult Zebu were monitored for 24 weeks during the dry season. Blood samples were collected on a weekly basis and subjected to parasitological and haematological analysis (n = 480), using the buffy-coat method and the packed cell volume value (PCV), respectively, infected animals were treated with a single intramuscular injection of diminazene aceturate (8 mg/kg)...
February 14, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28192798/identification-of-angpt2-as-a-new-gene-for-neovascular-age-related-macular-degeneration-and-polypoidal-choroidal-vasculopathy-in-the-chinese-and-japanese-populations
#5
Li Ma, Marten E Brelen, Motokazu Tsujikawa, Haoyu Chen, Wai Kit Chu, Timothy Y Y Lai, Danny S C Ng, Kaori Sayanagi, Chicako Hara, Noriyasu Hashida, Vesta C K Chan, Pancy O S Tam, Alvin L Young, Weiqi Chen, Kohji Nishida, Chi Pui Pang, Li Jia Chen
Purpose: We determine the angiopoietin 2 (ANGPT2) gene as a new susceptibility gene for neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV). Methods: A total of 34 haplotype-tagging single-nucleotide polymorphisms (SNPs) were first genotyped in an exploratory Hong Kong Chinese cohort. Suggestive SNPs were replicated in a Shantou Chinese cohort and an Osaka Japanese cohort, with a total of 2343 subjects. The SNP rs800292 in the complement factor H (CFH) gene was genotyped in all the subjects...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28182020/effect-of-ayurveda-medications-kas%C3%A4-sa-bhasma-and-dh%C3%A4-tr%C3%A4-avaleha-on-iron-deficiency-anaemia-a-randomized-controlled-study
#6
Basavaraj Ramappa Tubaki, Jyoti Mahadev Benni, Niranjan Rao, Uchangi Nagaraja Rao Prasad
BACKGROUND: This paper explores the role that Ayurveda can play in the management of Iron Deficiency Anaemia, a major nutritional deficiency disorder affecting people across the globe. METHODOLOGY: Forty (40) patients suffering from Iron deficiency anaemia as per WHO guidelines, between the age group of 20 to 60 yrs of either sex participated in the study. Study was a randomized, controlled, open label clinical study. Patients were randomly divided into two groups: Group D (n = 20) received Dhārī avaleha 10 g twice a day after food...
July 2016: Ancient Science of Life
https://www.readbyqxmd.com/read/28168172/comparison-of-immunogenicity-and-safety-of-an-influenza-vaccine-administered-concomitantly-with-a-13-valent-pneumococcal-conjugate-vaccine-or-23-valent-polysaccharide-pneumococcal-vaccine-in-the-elderly
#7
Yu Bin Seo, Won Suk Choi, Jacob Lee, Joon Young Song, Hee Jin Cheong, Woo Joo Kim
PURPOSE: Previous studies have demonstrated the immunogenicity and safety of the co-administration of the trivalent inactivated influenza vaccine (IIV3) with the polysaccharide pneumococcal vaccine (PPV) or pneumococcal conjugate vaccine (PCV). However, there is no direct comparison study that evaluates the immunogenicity and safety of IIV3 given concomitantly with PCV13 or PPV23 in the elderly. MATERIALS AND METHODS: During the 2012-2013 influenza vaccination period, 224 healthy elderly volunteers aged 65 years and older randomly received IIV3 given concomitantly with either PCV13 (PCV13+IIV3) or PPV23 (PPV23+IIV3) in a 1:1 ratio...
January 2017: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/28166256/high-pneumonia-lifetime-ever-incidence-in-beijing-children-compared-with-locations-in-other-countries-and-implications-for-national-pcv-and-hib-vaccination
#8
Fang Qu, Louise B Weschler, Yuexia Sun, Jan Sundell
OBJECTIVES: To compare the proportion of Beijing children who have ever had pneumonia (%Pneumonia) to those in other locations, and to estimate by how much national vaccine coverage with Pneumococcal Conjugate Vaccine (PCV) and Haemophilus Influenzae Type b (Hib) could reduce Beijing %Pneumonia. METHODS: %Pneumonia was obtained for each age group from 1 to 8 years inclusive from 5,876 responses to a cross-sectional questionnaire. Literature searches were conducted for world-wide reports of %Pneumonia...
2017: PloS One
https://www.readbyqxmd.com/read/28161425/the-rise-and-fall-of-pneumococcal-serotypes-carried-in-the-pcv-era
#9
Vanessa T Devine, David W Cleary, Johanna M C Jefferies, Rebecca Anderson, Denise E Morris, Andrew C Tuck, Rebecca A Gladstone, Grace O'Doherty, Priyasharmila Kuruparan, Stephen D Bentley, Saul N Faust, Stuart C Clarke
Streptococcus pneumoniae is a major cause of meningitis, sepsis and pneumonia worldwide. Vaccination using pneumococcal conjugate vaccines (PCV) has therefore been part of the UK's childhood immunisation programme since 2006. Here we describe pneumococcal carriage rates in children under five years of age attending the paediatric department of a large UK hospital in response to vaccine implementation over seven winter seasons from 2006 to 2013. S. pneumoniae (n=696) were isolated from nasopharyngeal swabs (n=2267) collected during seven consecutive winters, October to March, 2006/7 to 2012/13...
February 1, 2017: Vaccine
https://www.readbyqxmd.com/read/28154791/acute-angle-closure-glaucoma-secondary-to-polypoidal-choroidal-vasculopathy-a-devastating-complication
#10
Prabu Baskaran, Manavi D Sindal, Pankaja Dhoble, Seema Ramakrishnan, Venkatesh Rengaraj, Pradeep Ramulu
Acute angle closure glaucoma (ACG) in the setting of polypoidal choroidal vasculopathy (PCV) is a catastrophic complication that has been documented infrequently in literature. Ours is the second only report that describes hemorrhagic choroidal detachment as an event leading to acute angle closure glaucoma in PCV patients and the first one to describe the use of diode cyclophotocoagulation (CPC) for this condition. The purpose of this article is to familiarize readers with this entity that has an extremely dismal visual prognosis...
2017: GMS Ophthalmology Cases
https://www.readbyqxmd.com/read/28152199/investigation-of-perioperative-and-anesthetic-variables-affecting-short-term-survival-of-horses-with-small-intestinal-strangulating-lesions
#11
Pablo Espinosa, Sarah S Le Jeune, Alessia Cenani, Philip H Kass, Robert J Brosnan
OBJECTIVE: To determine if preoperative and intraoperative physiologic variables, and surgical factors correlate with survival to anesthetic recovery or hospital discharge, repeat celiotomy, and postoperative nasogastric intubation (NGT) in horses undergoing exploratory celiotomy for small intestinal (SI) strangulating lesions. STUDY DESIGN: Retrospective case series. ANIMALS: Horses that had surgical correction of SI strangulating lesions (n = 258)...
February 2, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28150038/choroidal-structures-in-polypoidal-choroidal-vasculopathy-neovascular-age-related-maculopathy-and-healthy-eyes-determined-by-binarization-of-swept-source-optical-coherence-tomographic-images
#12
Malini Bakthavatsalam, Danny Siu-Chun Ng, Frank Hiu-Ping Lai, Fang Yao Tang, Mårten Erik Brelén, Chi Wai Tsang, Timothy Yuk-Yau Lai, Carol Yim-Lui Cheung
PURPOSE: To evaluate quantitatively the choroidal vascularity in polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (AMD) patients compared to healthy controls. METHODS: All eyes underwent swept source optical coherence tomography (OCT), and choroidal images were binarized into blood vessels lumen and stroma. The choroidal vascular index (CVI) was defined as the ratio of luminal area (LA) over total choroidal area of the subfoveal region with a width of 1500 μm...
February 1, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28146590/epidemiology-of-otitis-media-with-spontaneous-perforation-of-the-tympanic-membrane-in-young-children-and-association-with-bacterial-nasopharyngeal-carriage-recurrences-and-pneumococcal-vaccination-in-catalonia-spain-the-prospective-hermes-study
#13
Robert Cilveti, Montserrat Olmo, Josefa Pérez-Jove, Juan-José Picazo, Josep-Lluis Arimany, Emiliano Mora, Tomás M Pérez-Porcuna, Ignacio Aguilar, Aurora Alonso, Francesc Molina, María Del Amo, Cristina Mendez
The Epidemiology of otitis media with spontaneous perforation of the tympanic membrane and associated nasopharyngeal carriage of bacterial otopathogens was analysed in a county in Catalonia (Spain) with pneumococcal conjugate vaccines (PCVs) not included in the immunization programme at study time. A prospective, multicentre study was performed in 10 primary care centres and 2 hospitals (June 2011-June 2014), including all otherwise healthy children ≥2 months ≤8 years with otitis media presenting spontaneous tympanic perforation within 48h...
2017: PloS One
https://www.readbyqxmd.com/read/28145972/detailed-characterization-of-choroidal-morphologic-and-vascular-features-in-age-related-macular-degeneration-and-polypoidal-choroidal-vasculopathy
#14
Preeti Gupta, Daniel Shu Wei Ting, Sri Gowtham Thakku, Tien-Yin Wong, Ching-Yu Cheng, Edmund Wong, Ranjana Mathur, Doric Wong, Ian Yeo, Chui Ming Gemmy Cheung
PURPOSE: To characterize and compare morphologic and vascular features of the choroid in patients with typical age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) and to determine if PCV subtypes can be identified based on these choroidal features. METHODS: Choroidal features of patients with AMD and PCV recruited from the prospectively planned Asian AMD Phenotyping Study were analyzed. Patients underwent choroidal imaging using spectral-domain optical coherence tomography with enhanced depth imaging...
January 31, 2017: Retina
https://www.readbyqxmd.com/read/28140694/genotoxic-and-hematological-effects-of-chlorpyrifos-exposure-on-freshwater-fish-labeo-rohita
#15
Muhammad Ismail, Rahat Ali, Muhammad Shahid, Muhammad Asaf Khan, Muhammad Zubair, Tayyaba Ali, Qaiser Mahmood Khan
Chlorpyrifos is a commonly used organophosphate insecticide that causes toxicological effects in aquatic organisms especially in fish. This study determined the effects of chlorpyrifos on the genotoxic and hematological parameters of freshwater fish, Labeo rohita. The genotoxic effects of different sublethal concentrations of chlorpyrifos were investigated in the erythrocytes of Labeo rohita (commonly known as Rohu) using the Micronucleus test. Effects of chlorpyrifos on the hematological parameters of the fish were also observed...
January 31, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28139954/a-need-for-dynamic-hematology-and-serum-biochemistry-reference-tools-novel-use-of-sine-wave-functions-to-produce-seasonally-varying-reference-curves-in-platypuses-ornithorhynchus-anatinus
#16
James W Macgregor, Carly S Holyoake, Joanne H Connolly, Ian D Robertson, Patricia A Fleming, Kristin S Warren
Seasonal changes in hematology and serum biochemistry results, described by separate reference intervals for different seasons, have been reported in many animals. We developed a novel method to investigate seasonal variation in values and a reference tool (the reference curve) based on sine wave functions that, for suitable variables, represents data more appropriately than a fixed reference interval. We applied these techniques to values observed in blood samples from 126 adult wild platypuses ( Ornithorhynchus anatinus ) (58 females and 68 males)...
January 31, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28138395/effect-of-age-on-heart-rate-blood-lactate-concentration-packed-cell-volume-and-hemoglobin-to-exercise-in-jeju-crossbreed-horses
#17
Ok-Deuk Kang, Yong-Soo Park
BACKGROUND: This study aimed to analyze the on heart rate, blood lactate concentration, packed cell volume (PCV) and hemoglobin (Hb) response after conducting exercise in endurance horses. METHODS: A total of 20 healthy 3-9-years-old Jeju crossbreed mares (5.95 ± 2.24 year) of age and 312.65 ± 13.59 kg of weight) currently participating the endurance competition were used. The field tests selected for the experiment was gallop (approximately 8.3 m/s) along the selected 2...
2017: Journal of Animal Science and Technology
https://www.readbyqxmd.com/read/28133541/putatively-novel-serotypes-and-the-potential-for-reduced-vaccine-effectiveness-capsular-locus-diversity-revealed-among-5405-pneumococcal-genomes
#18
Andries J van Tonder, James E Bray, Sigríður J Quirk, Gunnsteinn Haraldsson, Keith A Jolley, Martin C J Maiden, Steen Hoffmann, Stephen D Bentley, Ásgeir Haraldsson, Helga Erlendsdóttir, Karl G Kristinsson, Angela B Brueggemann
The pneumococcus is a leading global pathogen and a key virulence factor possessed by the majority of pneumococci is an antigenic polysaccharide capsule ('serotype'), which is encoded by the capsular (cps) locus. Approximately 100 different serotypes are known, but the extent of sequence diversity within the cps loci of individual serotypes is not well understood. Investigating serotype-specific sequence variation is crucial to the design of sequence-based serotyping methodology, understanding pneumococcal conjugate vaccine (PCV) effectiveness and the design of future PCVs...
October 1, 2016: Microbial Genomics
https://www.readbyqxmd.com/read/28127368/performance-and-parasitology-of-semi-intensively-managed-west-african-dwarf-sheep-exposed-to-gastrointestinal-helminth-infected-paddocks-and-varied-protein-energy-feeds
#19
Adekayode Olarinwaju Sonibare, Olusiji Sunday Sowande, Shamusideen Oladeinde Iposu, Joshua Luka, Michael Ayankosoi, Adeniyi Olugbega Egbetade
BACKGROUND: The performance and parasitology of semi-intensively managed West African dwarf (WAD) lambs were evaluated following exposure to gastrointestinal helminth infected paddock and varied protein-energy feeds. METHODS: Twenty four lambs obtained from the Department of Animal Breeding and Genetics and brought to Directorate of University farm (DUFARM) of Federal University of Agriculture Abeokuta, Ogun state, Nigeria, where the research was carried out in 2014, were grouped into four each containing six animals based on different energy-protein feed combination thus; group 1(G1) low energy low protein, group 2 (G2) low energy high protein, group 3 (G3) high energy low protein and group 4 (G4) high energy high protein...
October 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28125317/pneumococcal-serotype-distribution-a-snapshot-of-recent-data-in-pediatric-and-adult-populations-around-the-world
#20
Yadong A Cui, Harshila Patel, William M O'Neil, Se Li, Patricia Saddier
S. pneumoniae infection remains a serious public health concern despite the availability of vaccines covering up to 23 of more than 94 known serotypes. The purpose of the present study was to monitor recent serotype distribution data. PubMed, EMBASE, Cochrane Reviews and Ingenta databases were searched. Serotype data covering invasive pneumococcal disease (IPD) and non-IPD were extracted from articles published from March 2014 to March 2015. Fifty-nine studies presented pneumococcal serotype prevalence by specific age categories...
January 26, 2017: Human Vaccines & Immunotherapeutics
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