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https://www.readbyqxmd.com/read/28333703/higher-fresh-gas-flow-rates-decrease-tidal-volume-during-pressure-control-ventilation
#1
Shazia Mohammad, Nikolaus Gravenstein, Drew Gonsalves, Terrie Vasilopoulos, Samsun Lampotang
BACKGROUND: We observed that increasing fresh gas flow (FGF) decreased exhaled tidal volume (VT) during pressure control ventilation (PCV). A literature search produced no such description whereby unintended VT changes occur with FGF changes during PCV. METHODS: To model an infant's lungs, 1 lung of a mechanical lung model (Dual Adult TTL 1600; Michigan Instruments, Inc, Grand Rapids, MI) was set at a compliance of 0.0068 L/cm H2O. An Rp50 resistor (27.2 cm H2O/L/s at 15 L/min) simulated normal bronchial resistance...
March 22, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28328679/results-of-a-multicenter-prospective-pivotal-trial-of-the-first-inline-continuous-glucose-monitor-in-critically-ill-patients
#2
Grant V Bochicchio, Stan Nasraway, Laura Moore, Anthony Furnary, Eden Nohra, Kelly Bochicchio
INTRODUCTION: We have previously demonstrated that tight glycemic control (80-120 mg/dl) improves outcome in critically injured patients. However, many centers have gotten away from aggressive glucose control due to the workload and risk of hypoglycemia. The objective of this pivotal trial is to evaluate the first in human continuous inline glucose monitor (OptiScanner) in critically ill patients. METHODS: A multicenter pivotal trial was conducted over a 1 year period (2014-2015) at 4 major academic centers in 200 critically ill patients...
March 21, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28327779/-occurrence-of-genotypes-of-porcine-circovirus-in-pig-farms-using-different-vaccination-strategies
#3
Matthias Eddicks, Florian Szikora, Nils Walhöfer, Carola Sauter Louis, Sven Reese, Elisabeth Banholzer, Gerald Reiner, Gerd Sutter, Mathias Ritzmann, Robert Fux
OBJECTIVE: Since 2004/2005 a worldwide shift of the detection rate of porcine circovirus (PCV) has been observed from PCV2a towards PCV2b. Currently commercially available vaccines are based on genotype PCV2a. The study was conducted as a pilot study to evaluate the occurrence of PCV2a and PCV2b in farms with different vaccination strategies against PCV2. MATERIAL AND METHODS: For this purpose a total of 405 piglets originating from nine farms (three farms with sow vaccination [SI], piglet vaccination [FI] and no vaccination [NI] against PCV2, respectively) were enrolled and followed from day 3 of life until slaughter...
March 22, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/28324878/comparison-of-the-12-month-outcomes-of-intravitreal-ranibizumab-between-two-angiographic-subtypes-of-polypoidal-choroidal-vasculopathy
#4
Shunichiro Nakai, Shigeru Honda, Akiko Miki, Wataru Matsumiya, Makoto Nakamura
BACKGROUND: To compare the 12-month outcomes of intravitreal ranibizumab (IVR) between two angiographic subtypes of polypoidal choroidal vasculopathy (PCV). METHODS: This is a retrospective cohort study of 38 treatment-naïve PCV cases. Three consecutive IVR and retreatments as needed were performed. Subsequently, the PCV cases were classified into two phenotypes (18 type 1 and 20 type 2) according to the status of branching vascular network. The best-corrected visual acuity (BCVA) was evaluated in each PCV subtype up to 12 months after the initial IVR...
March 22, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28324811/serum-acute-phase-response-induced-by-different-vaccination-protocols-against-circovirus-type-2-and-mycoplasma-hyopneumoniae-in-piglets
#5
Iván Hernández-Caravaca, Sebastian Figueras Gourgues, Víctor Rodríguez, Edgar Díaz Estrada, José J Cerón, Damián Escribano
The purpose of this study was to compare the acute phase reaction (APR) induced by different vaccination protocols used against Porcine Circovirus (PCV) type-2 and Mycoplasma hyopneumoniae (M.hyo), studying two acute phase proteins (APPs) and changes in rectal temperature (RT). In addition, the possible influence of the time of vaccination and breed were analysed. In the first experiment, 40 commercial crossbred piglets were vaccinated, on the day of weaning, with FLEXcombo® (group A, n=20) or Porcilis PCV® and Stellamune® One (group B, n=20)...
March 11, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28321136/procarbazine-lomustine-and-vincristine-pcv-regimen-for-central-nervous-system-tumors
#6
Dominic A Solimando, J Aubrey Waddell
The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr, President, Oncology Pharmacy Services, Inc., 4201 Wilson Blvd #110-545, Arlington, VA 22203, e-mail: OncRxSvc@comcast...
February 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28318472/antimicrobial-resistance-penicillin-binding-protein-sequences-and-pilus-islet-carriage-in-relation-to-clonal-evolution-of-streptococcus-pneumoniae-serotype-19a-in-russia-2002-2013
#7
N Mayanskiy, T Savinova, N Alyabieva, O Ponomarenko, E Brzhozovskaya, A Lazareva, L Katosova, R Kozlov
Clonal changes of serotype 19A pneumococci have been appreciated in conjunction with growing prevalence of this serotype after implementation of the seven-valent pneumococcal conjugate vaccine (PCV7). In the present study, we characterized serotype 19A pneumococci collected in Russia within a decade preceding the implementation of PCV vaccination and described their clonal evolution. We retrospectively analyzed non-invasive serotype 19A isolates collected in 2002-2013. All isolates were subjected to multilocus sequence typing, antimicrobial susceptibility testing, determination of macrolide resistance genotype, molecular detection of pilus islet (PI) carriage, sequencing of penicillin-binding protein (PBP) genes...
March 20, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28300529/sex-differences-in-invasive-pneumococcal-disease-and-the-impact-of-pneumococcal-conjugate-vaccination-in-the-netherlands-2004-to-2015
#8
Gertjan H J Wagenvoort, Elisabeth A M Sanders, Bart J Vlaminckx, Hester E de Melker, Arie van der Ende, Mirjam J Knol
Implementation of pneumococcal conjugate vaccines in the Netherlands (PCV7 in 2006 and PCV10 in 2011) for infants caused a shift in serotypes in invasive pneumococcal disease (IPD). We explored sex differences in serotype-specific IPD incidence before and after vaccine introduction. Incidences in the pre-PCV7 (June 2004-May 2006), post-PCV7 (June 2008-May 2011) and post-PCV10 period (June 2013-May 2015), stratified by age, were compared. Incidence was higher in men for all age groups (overall in men: 16.7, 15...
March 9, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28298784/ventilation-of-nonparalyzed-patients-under-anesthesia-with-laryngeal-mask-airway-comparison-of-three-modes-of-ventilation-volume-controlled-ventilation-pressure-controlled-ventilation-and-pressure-controlled-ventilation-volume-guarantee
#9
Maroun Badwi Ghabach, Elie M El Hajj, Rouba D El Dib, Jeanette M Rkaiby, May S Matta, May R Helou
BACKGROUND: Pressure controlled ventilation (PCV) is the preferable mode of ventilation of nonparalyzed patients undergoing anesthesia with laryngeal mask airway (LMA) as compared to volume controlled ventilation (VCV) and spontaneously breathing patient. In this study, we compared the PC-volume guarantee (PC-VG) mode of ventilation with VCV and PCV modes. MATERIALS AND METHODS: A total of 30 patients, American Society of Anesthesiologists (ASA) physical status Classes I and II, scheduled for elective surgery under general anesthesia with a classic LMA were ventilated, subsequently, with the three modes of ventilation: VCV, PCV, and PC-VG for 10 min each mode...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28298763/effect-of-switching-between-pressure-controlled-and-volume-controlled-ventilation-on-respiratory-mechanics-and-hemodynamics-in-obese-patients-during-abdominoplasty
#10
Medhat Mikhail Messeha
BACKGROUND: The ideal intraoperative ventilation strategy in obese patients remains obscure. This prospective, randomized study was designed to evaluate the effect of pressure-controlled ventilation (PCV) before or after volume-controlled ventilation (VCV) on lung mechanics and hemodynamics variables in obese patients subjected to abdominoplasty operation. PATIENTS AND METHODS: The study included forty patients with body mass index 30-45 kg/m(2) subjected to abdominoplasty...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28292980/streptococcus-pneumoniae-transmission-is-blocked-by-type-specific-immunity-in-an-infant-mouse-model
#11
Tonia Zangari, Yang Wang, Jeffrey N Weiser
Epidemiological studies on Streptococcus pneumoniae show that rates of carriage are highest in early childhood and that the major benefit of the pneumococcal conjugate vaccine (PCV) is a reduction in the incidence of nasopharyngeal colonization through decreased transmission within a population. In this study, we sought to understand how anti-S. pneumoniae immunity affects nasal shedding of bacteria, the limiting step in experimental pneumococcal transmission. Using an infant mouse model, we examined the role of immunity (passed from mother to pup) on shedding and within-litter transmission of S...
March 14, 2017: MBio
https://www.readbyqxmd.com/read/28289429/hematological-and-plasma-biochemical-parameters-in-a-wild-population-of-naja-naja-linnaeus-1758-in-sri-lanka
#12
Duminda S B Dissanayake, Lasanthika D Thewarage, Rathnayake M P Manel Rathnayake, Senanayake A M Kularatne, Jamburagoda G Shirani Ranasinghe, Rajapakse P V Jayantha Rajapakse
BACKGROUND: Hematological studies of any animal species comprise an important diagnostic method in veterinary medicine and an essential tool for the conservation of species. In Sri Lanka, this essential technique has been ignored in studies of many species including reptiles. The aim of the present work was to establish a reference range of hematological values and morphological characterization of wild spectacled cobras (Naja naja) in Sri Lanka in order to provide a diagnostic tool in the assessment of health condition in reptiles and to diagnose diseases in wild populations...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28284682/childhood-pneumococcal-disease-in-africa-a-systematic-review-and-meta-analysis-of-incidence-serotype-distribution-and-antimicrobial-susceptibility
#13
REVIEW
Pui-Ying Iroh Tam, Beth K Thielen, Stephen K Obaro, Ann M Brearley, Alexander M Kaizer, Haitao Chu, Edward N Janoff
BACKGROUND: Determining the incidence, disease-associated serotypes and antimicrobial susceptibility of invasive pneumococcal disease (IPD) among children in Africa is essential in order to monitor the impact of these infections prior to widespread introduction of the pneumococcal conjugate vaccine (PCV). METHODS: To provide updated estimates of the incidence, serotype distribution, and antimicrobial susceptibility profile of Streptococcus pneumoniae causing disease in Africa, we performed a systematic review of articles published from 2000 to 2015 using Ovid Medline and Embase...
March 8, 2017: Vaccine
https://www.readbyqxmd.com/read/28284610/association-of-ehrlichia-canis-hemotropic-mycoplasma-spp-and-anaplasma-platys-and-severe-anemia-in-dogs-in-thailand
#14
Gunn Kaewmongkol, Nicha Lukkana, Sarawut Yangtara, Sarawan Kaewmongkol, Naris Thengchaisri, Theerapol Sirinarumitr, Sathaporn Jittapalapong, Stanley G Fenwick
Canine tick-borne bacteria; Ehrlichia canis, hemotropic Mycoplasma spp. and Anaplasma spp., are organisms transmitted by Rhipicephalus sanguineus ticks. However, only a few clinical studies evaluating dogs infected with these organisms and anemia condition have been published. In this study, the potential tick-borne bacteria linked to anemia were investigated in eighty-one blood samples selected from anemic dogs using a broad range nested-PCR of the 16S rRNA gene. Positive results were shown in 12/81 blood specimens (14...
March 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28282700/-choroidal-neovascularisation-other-than-typical-neovascular-age-related-macular-degeneration
#15
D Sandner
Choroidal neovascularisation (CNV) in the context of exsudative age-related macular degeneration (nAMD) can be divided into type 1 (occult) and type 2 (classical) membranes. Retinal angiomatous proliferation (RAP) or polypoidal choroidal vasculopathy (PCV) are "rare subtypes" of chorioretinal neovascularisation and are distinguished by their distinct morphology and the sometimes worse response to therapy. Chorioretinal anastomosis, severe exsudates with serosanguinous pigment epithelial detachment and, in PCV, orange-red lesions in the papillomacular bundle can be diagnostic...
March 10, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28281173/glioma-subclassifications-and-their-clinical-significance
#16
REVIEW
Ricky Chen, Matthew Smith-Cohn, Adam L Cohen, Howard Colman
The impact of targeted therapies in glioma has been modest. All the therapies that have demonstrated a significant survival benefit for gliomas in Phase III trials, including radiation, chemotherapy (temozolomide and PCV [procarbazine, lomustine, vincristine]), and tumor-treating fields, are based on nonspecific targeting of proliferating cells. Recent advances in the molecular understanding of gliomas suggest some potential reasons for the failure of more targeted therapies in gliomas. Specifically, the histologic-based glioma classification is composed of multiple different molecular subtypes with distinct biology, natural history, and prognosis...
March 9, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28275739/rapid-kinetics-of-serum-iga-after-vaccination-with-prevnar-%C3%A2-13-followed-by-pneumovax-%C3%A2-23
#17
Rebecca R Crowther, Christine M Collins, Cheryl Conley, Osvaldo J Lopez
Streptococcus pneumoniae is a causative agent of community-acquired pneumonias. The recommendations of the 2012 Advisory Committee on Immunization Practices include vaccination with Prevnar(®)13 (protein-polysaccharide conjugate vaccine; PCV), followed by Pneumovax(®)23 (polysaccharide-based vaccine; PSV) in adults 65+ or the immunocompromised. In this experiment, a group of 4 healthy volunteers were vaccinated with PCV followed by PSV 60 days later. ELISAs were optimized to study kinetics of IgA, IgM, total IgG and its four subclasses against 14 polysaccharides of the pneumococcal capsule...
February 2017: Heliyon
https://www.readbyqxmd.com/read/28270486/polypoidal-choroidal-vasculopathy-a-common-type-of-neovascular-age-related-macular-degeneration-in-caucasians
#18
Sohraab Yadav, David G Parry, Nick A V Beare, Ian A Pearce
AIMS: To describe the prevalence of polypoidal choroidal vasculopathy (PCV) in a Caucasian population with neovascular age-related macular degeneration (NAMD). METHODS: All patients referred to a city AMD service over a 2-year period underwent imaging including Indocyanine Green Angiography at baseline. A panel of experts confirmed the patients with NAMD and diagnosed the lesion type including PCV. The proportion of Caucasian patients with PCV was identified. Two authors independently reviewed clinical imaging and recorded data of patients with PCV on lesion characteristics...
March 7, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28266609/incidence-and-risk-factors-of-retreatment-after-three-monthly-aflibercept-therapy-for-exudative-age-related-macular-degeneration
#19
Wataru Kikushima, Yoichi Sakurada, Seigo Yoneyama, Atsushi Sugiyama, Naohiko Tanabe, Atsuki Kume, Fumihiko Mabuchi, Hiroyuki Iijima
Though anti-vascular endothelial growth factor therapy has become the standard treatment for exudative age-related macular degeneration (AMD), retreatment after the initial loading injection is inevitable in most eyes with residual or recurrent exudative changes. In the present study, we studied 140 treatment naïve eyes with typical neovascular AMD (n = 71) or polypoidal choroidal vasculopathy (PCV) (n = 69) and investigated the incidence and risk factors of retreatment after 3-monthly intravitreal aflibercept injection for exudative AMD during the 12-month period...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28256075/the-use-of-darbepoetin-to-stimulate-erythropoiesis-in-the-treatment-of-anemia-of-chronic-kidney-disease-in-dogs
#20
E H Fiocchi, L D Cowgill, D C Brown, J E Markovich, S Tucker, M A Labato, M B Callan
BACKGROUND: Darbepoetin alfa (darbepoetin) is an erythropoiesis-stimulating agent used for the treatment of anemia secondary to chronic kidney disease (CKD) in dogs, but reports describing response are lacking. HYPOTHESIS/OBJECTIVES: To evaluate the effectiveness of darbepoetin in dogs with anemia secondary to CKD, dosing protocols, and adverse events. ANIMALS: Thirty-three client-owned dogs with naturally occurring CKD, including 26 with comorbidities...
March 2017: Journal of Veterinary Internal Medicine
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