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https://www.readbyqxmd.com/read/28912634/posterior-hip-instability-relocation-testing-a-resident-s-case-report
#1
Rich Maas, Scott Wallentine, Dale Gerke, Sam Crager, Jessica Stewart
BACKGROUND: Micro-instability (non-radiographic clinical instability) continues to gain recognition as a problem at the hip. Although most research has been directed to anterior hip instability, posterior hip instability (PHI) has also garnered attention. PHI is under recognized, difficult to identify, and confused with other hip pathologies such as a simple sprain or strain. A novel clinical test is introduced that may have helped identify PHI in this patient. Additionally, a conservative rehabilitation approach emphasizing stabilization exercises is described...
September 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/28903493/editor-s-highlight-formulation-and-toxicology-evaluation-of-the-intrathecal-ayx1-dna-decoy-in-sprague-dawley-rats
#2
Julien Mamet, David C Yeomans, Tony L Yaksh, Donald C Manning, Scott Harris
The longevity of pain after surgery is debilitating and limits the recovery of patients. AYX1 is a double-stranded, unprotected, 23 base-pair oligonucleotide designed to reduce acute post-surgical pain and prevent its chronification with a single intrathecal perioperative dose. AYX1 mimics the DNA sequence normally bound by EGR1 on chromosomes, a transcription factor transiently induced in the dorsal root ganglia-spinal cord network following a noxious input. AYX1 binds to EGR1 and prevents it from launching waves of gene regulation that are necessary to maintain pain over time...
September 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28900572/return-to-running-following-a-knee-disarticulation-amputation-a-case-report
#3
Angela R Diebal-Lee, Robert S Kuenzi, Christopher A Rábago
BACKGROUND AND PURPOSE: The evolution of running-specific prostheses has empowered athletes with lower extremity amputations to run farther and faster than previously thought possible; but running with proper mechanics is still paramount to an injury-free, active lifestyle. The purpose of this case report was to describe the successful alteration of intact limb mechanics from a Rearfoot Striking (RFS) to a Non-Rearfoot Striking (NRFS) pattern in an individual with a knee disarticulation amputation, the associated reduction in Average Vertical Loading Rate (AVLR), and the improvement in functional performance following the intervention...
August 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28885356/correlations-between-lumbar-neuromuscular-function-and-pain-lumbar-disability-in-patients-with-nonspecific-low-back-pain-a-cross-sectional-study
#4
Haoyu Hu, Yili Zheng, Xueqiang Wang, Binglin Chen, Yulin Dong, Juan Zhang, Xiaochen Liu, Di Gong
This study aims to examine the correlations between lumbar neuromuscular function and pain, lumbar disability in patients with nonspecific low back pain (NSLBP).Ninety patients, with ages 18 to 37 years old, with NSLBP were recruited in this study. The lumbar neuromuscular function was tested by the CON-TREX multijoint isokinetic test and training machine. This study uses the visual analog scale (VAS) and Roland-Morris Disability Questionnaire (RMDQ) to evaluate the pain and the dysfunction index of patients who have low back pain, respectively...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28878618/the-non-survival-effects-of-glial-cell-line-derived-neurotrophic-factor-on-neural-cells
#5
REVIEW
Daniel Cortés, Oscar A Carballo-Molina, María José Castellanos-Montiel, Iván Velasco
Glial cell line-derived neurotrophic factor (GDNF) was first characterized as a survival-promoting molecule for dopaminergic neurons (DANs). Afterwards, other cells were also discovered to respond to GDNF not only as a survival factor but also as a protein supporting other cellular functions, such as proliferation, differentiation, maturation, neurite outgrowth and other phenomena that have been less studied than survival and are now more extendedly described here in this review article. During development, GDNF favors the commitment of neural precursors towards dopaminergic, motor, enteric and adrenal neurons; in addition, it enhances the axonal growth of some of these neurons...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28877943/systematic-review-of-the-evidence-on-orthotic-devices-for-the-management-of-knee-instability-related-to-neuromuscular-and-central-nervous-system-disorders
#6
Catriona McDaid, Debra Fayter, Alison Booth, Joanne O'Connor, Rocio Rodriguez-Lopez, Dorothy McCaughan, Roy Bowers, Cynthia P Iglesias, Simon Lalor, Rory J O'Connor, Margaret Phillips, Gita Ramdharry
OBJECTIVES: To assess the effectiveness of orthotic devices for the management of instability of the knee in adults with a neuromuscular disorder or central nervous system disorder. DESIGN: A systematic review of primary studies. SETTING: Community. PARTICIPANTS: Adults with a neuromuscular disorder or central nervous system disorder and impaired walking ability due to instability of the knee. INTERVENTIONS: Orthoses with the clinical aim of controlling knee instability, for example, knee-ankle-foot orthoses, ankle-foot orthoses and knee orthoses or mixed design with no restrictions in design or material...
September 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28877095/hip-surveillance-for-children-with-cerebral-palsy-a-survey-of-the-posna-membership
#7
Benjamin J Shore, Michael W Shrader, Unni Narayanan, Freeman Miller, H Kerr Graham, Kishore Mulpuri
BACKGROUND: Currently, hip surveillance programs for children with cerebral palsy exist in Europe, Australasia, and parts of Canada, but a neuromuscular hip surveillance program has yet to be adopted in the United States. The purpose of this study was to report the current orthopaedic practice of hip surveillance in children with cerebral palsy, identify areas of practice variation, and suggest steps moving forward to generate guidelines for national neuromuscular hip surveillance. METHODS: The entire membership of the Pediatric Orthopaedic Society of North America (POSNA) was surveyed in 2016 for information regarding their practice for hip surveillance in children with cerebral palsy...
October 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28873075/intraoperative-magnesium-sulphate-decreases-agitation-and-pain-in-patients-undergoing-functional-endoscopic-surgery-a-randomised-double-blind-study
#8
Hazem E Elsersy, Magdy Ch Metyas, Hana A Elfeky, Ahmed A Hassan
BACKGROUND: Postoperative agitation is harmful for the patient as it may be associated with removal of catheters, nasal packs, oxygen masks and self-injury, and pose a danger to operating theatre staff. OBJECTIVE: The current study investigated the potential role of magnesium sulphate in treatment of postoperative agitation following functional endoscopic sinus surgery. DESIGN: A randomised, double-blinded, placebo-controlled trial. SETTING: ENT operating room, Menofia University Hospitals, Egypt...
October 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28870579/aberrant-microrna-expression-in-patients-with-painful-peripheral-neuropathies
#9
Mathias Leinders, Nurcan Üçeyler, Anna Thomann, Claudia Sommer
Changes in the neuro-immune balance play a major role in the induction and maintenance of neuropathic pain. We recently reported pathophysiologically relevant alterations in skin and sural nerve cytokine expression in peripheral neuropathies of different etiologies. Immune processes and cytokine expression are under tight control of microRNAs (miRNAs). To identify potential master switches in the neuro-immune balance, we aimed at characterizing inflammation-regulating miRNA profiles in patients with peripheral neuropathies...
September 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28868303/adjuvants-to-local-anesthetics-current-understanding-and-future-trends
#10
EDITORIAL
Amlan Swain, Deb Sanjay Nag, Seelora Sahu, Devi Prasad Samaddar
Although beneficial in acute and chronic pain management, the use of local anaesthetics is limited by its duration of action and the dose dependent adverse effects on the cardiac and central nervous system. Adjuvants or additives are often used with local anaesthetics for its synergistic effect by prolonging the duration of sensory-motor block and limiting the cumulative dose requirement of local anaesthetics. The armamentarium of local anesthetic adjuvants have evolved over time from classical opioids to a wide array of drugs spanning several groups and varying mechanisms of action...
August 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28862761/effects-of-pulse-duration-on-muscle-fatigue-during-electrical-stimulation-inducing-moderate-level-contraction
#11
Woohyoung Jeon, Lisa Griffin
INTRODUCTION: Neuromuscular electrical stimulation (NMES) is used to prevent muscle atrophy. However, the effect of pulse duration modulation for reducing muscle fatigue and pain is unknown. METHODS: Two 2-minute stimulation protocols were applied to the knee extensors of 10 healthy individuals. In one session, a long pulse duration (1,000 μs) and a low current amplitude (LL) set to evoke 25% maximal voluntary contraction at 30 Hz were applied. The other session was identical except that a short pulse duration (200 μs) and a high current amplitude (SH) were used...
September 1, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28862529/an-algorithmic-approach-to-rehabilitation-following-arthroscopic-surgery-for-arthrofibrosis-of-the-knee-a-case-series
#12
Brian J Eckenrode
BACKGROUND AND PURPOSE: Loss of knee range of motion (ROM) has been reported as the most common complication following anterior cruciate ligament reconstruction (ACLR). Arthrofibrosis of the knee, or specifically Cyclops syndrome, has been described as the formation of a scar tissue nodule adjacent to the tibial tunnel of the anterior cruciate ligament (ACL) graft. This lesion often results in loss of knee extension ROM, pain, and impaired function. CASE DESCRIPTIONS: Three consecutive patients were referred to physical therapy following arthroscopic knee surgery for lysis of adhesions of a Cyclops lesion from a previous ACLR...
September 1, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28857524/concomitant-occurrence-of-fxtas-and-clinically-defined-sporadic-inclusion-body-myositis-report-of-two-cases
#13
Mirna Lechpammer, Verónica Martínez Cerdeńo, Michael Ryan Hunsaker, Mina Hah, Hilary Gonzales, Steve Tisch, Ronald Joffe, Roger Pamphlett, Flora Tassone, Paul J Hagerman, Samuel J Bolitho, Randi J Hagerman
This report describes unique presentations of inclusion body myositis (IBM) in two unrelated patients, one male and one female, with genetically and histologically confirmed fragile X-associated tremor/ataxia syndrome (FXTAS). We summarize overlapping symptoms between two disorders, clinical course, and histopathological analyses of the two patients with FXTAS and sporadic IBM, clinically defined per diagnostic criteria of the European Neuromuscular Centre. In case 1, a post-mortem analysis of available brain and muscle tissues is also described...
August 31, 2017: Croatian Medical Journal
https://www.readbyqxmd.com/read/28841697/dynamic-thoracohumeral-kinematics-are-dependent-upon-the-etiology-of-the-shoulder-injury
#14
Juan López-Pascual, Álvaro Page, Pilar Serra-Añó
Obtaining kinematic patterns that depend on the shoulder injury may be important when planning rehabilitation. The main goal of this study is to explore whether the kinematic patterns of continuous and repetitive shoulder elevation motions are different according to the type of shoulder injury in question, specifically tendinopathy or rotator cuff tear, and to analyze the influence of the load handled during its assessment. For this purpose, 19 individuals with tendinopathy and 9 with rotator cuff tear performed a repetitive scaption movement that was assessed with stereophotogrammetry...
2017: PloS One
https://www.readbyqxmd.com/read/28834856/review-of-continuous-infusion-neuromuscular-blocking-agents-in-the-adult-intensive-care-unit
#15
Keaton S Smetana, Neil A Roe, Bruce A Doepker, G Morgan Jones
The use of continuous infusion neuromuscular blocking agents remains controversial. The clinical benefit of these medications may be overshadowed by concerns of propagating intensive care unit-acquired weakness, which may prolong mechanical ventilation and impair the inability to assess neurologic function or pain. Despite these risks, the use of neuromuscular blocking agents in the intensive care unit is indicated in numerous clinical situations. Understanding pharmacologic nuances and clinical roles of these agents will aid in facilitating safe use in a variety of acute disease processes...
October 2017: Critical Care Nursing Quarterly
https://www.readbyqxmd.com/read/28827270/study-protocol-for-a-randomised-controlled-trial-of-meniscal-surgery-compared-with-exercise-and-patient-education-for-treatment-of-meniscal-tears-in-young-adults
#16
Søren Thorgaard Skou, Martin Lind, Per Hölmich, Hans Peter Jensen, Carsten Jensen, Muhammad Afzal, Uffe Jørgensen, Jonas Bloch Thorlund
INTRODUCTION: Arthroscopic surgery is a very common orthopaedic procedure. While several trials have investigated the effect of knee arthroscopy for middle-aged and older patients with meniscal tears, there is a paucity of trials comparing meniscal surgery with non-surgical treatment for younger adults. The aim of this randomised controlled trial (RCT) is to investigate if early arthroscopic surgery is superior to exercise therapy and education, with the option of later surgery if needed, in improving pain, function and quality of life in younger adults with meniscal tears...
August 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28821271/high-speed-resistance-training-and-balance-training-for-people-with-knee-osteoarthritis-to-reduce-falls-risk-study-protocol-for-a-pilot-randomized-controlled-trial
#17
Pazit Levinger, Jeremy Dunn, Nancy Bifera, Michael Butson, George Elias, Keith D Hill
BACKGROUND: The number of falls experienced by people with knee osteoarthritis (OA) is almost double the number experienced by people with no OA. The neuromuscular elements required to arrest a fall are more impaired in people with knee OA compared to their asymptomatic counterparts. Therefore, these elements may need to be incorporated into an exercise intervention to reduce the risk of falling. The aim of this study will be to examine the feasibility, safety and patient satisfaction of a high-speed resistance-training program, with and without balance exercises, in people with knee OA compared to a control group...
August 18, 2017: Trials
https://www.readbyqxmd.com/read/28816177/electrical-stimulation-of-gut-motility-guided-by-an-in-silico-model
#18
Bradley Brigham Barth, Craig S Henriquez, Warren M Grill, Xiling Shen
OBJECTIVE: Neuromodulation of the central and peripheral nervous systems is becoming increasingly important for treating a diverse set of diseases-ranging from Parkinson's Disease and epilepsy to chronic pain. However, neuromodulation of the gastrointestinal (GI) tract has achieved relatively limited success in treating functional GI disorders, which affect a significant population, because the effects of stimulation on the enteric nervous system (ENS) and gut motility are not well understood...
August 17, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28814015/postoperative-healing-patterns-in-elbow-using-electromyography-towards-the-development-of-a-wearable-mechatronic-elbow-brace
#19
Raneem Haddara, Yue Zhou, Shrikant Chinchalkar, Ana Luisa Trejos
Musculoskeletal (MSK) conditions are the most common cause of severe long-term pain and physical disability. Current postoperative treatment for patients requires them to follow a long-term physiotherapy program customized for each specific case; however, this process can be complex, time-consuming and without the right therapy it may end up being ineffective. A possible solution involves the development of wearable mechatronic elbow braces that use electromyography (EMG) to identify patient intent. However, EMG characteristics change based on the health of the individual and therefore require further investigation...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28806453/neurologic-complications-associated-with-the-zika-virus-in-brazilian-adults
#20
Ivan Rocha Ferreira da Silva, Jennifer A Frontera, Ana Maria Bispo de Filippis, Osvaldo Jose Moreira do Nascimento
Importance: There are no prospective cohort studies assessing the incidence and spectrum of neurologic manifestations secondary to Zika virus (ZIKV) infection in adults. Objective: To evaluate the rates of acute ZIKV infection among patients hospitalized with Guillain-Barré syndrome (GBS), meningoencephalitis, or transverse myelitis. Design, Setting, and Participants: A prospective, observational cohort study was conducted at a tertiary referral center for neurological diseases in Rio de Janeiro, Brazil, between December 5, 2015, and May 10, 2016, among consecutive hospitalized adults (>18 years of age) with new-onset acute parainfectious or neuroinflammatory disease...
August 14, 2017: JAMA Neurology
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