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Stephen J Mooney

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https://www.readbyqxmd.com/read/29050199/pre-clinical-pharmacology-of-azd3965-a-selective-inhibitor-of-mct1-dlbcl-nhl-and-burkitt-s-lymphoma-anti-tumor-activity
#1
Nicola J Curtis, Lorraine Mooney, Lorna Hopcroft, Filippos Michopoulos, Nichola Whalley, Haihong Zhong, Clare Murray, Armelle Logie, Mitchell Revill, Kate F Byth, Amanda D Benjamin, Mike A Firth, Stephen Green, Paul D Smith, Susan E Critchlow
Tumors frequently display a glycolytic phenotype with increased flux through glycolysis and concomitant synthesis of lactate. To maintain glycolytic flux and prevent intracellular acidification, tumors efflux lactate via lactate transporters (MCT1-4). Inhibitors of lactate transport have the potential to inhibit glycolysis and tumor growth. We developed a small molecule inhibitor of MCT1 (AZD3965) and assessed its activity across a panel of cell lines. We explored its antitumor activity as monotherapy and in combination with doxorubicin or rituximab...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28986599/use-of-firearms-in-terrorist-attacks-differences-between-the-united-states-canada-europe-australia-and-new-zealand
#2
Robert A Tessler, Stephen J Mooney, Cordelie E Witt, Kathleen O'Connell, Jessica Jenness, Monica S Vavilala, Frederick P Rivara
No abstract text is available yet for this article.
October 6, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28963748/cell-density-and-airspace-patterning-in-the-leaf-can-be-manipulated-to-increase-leaf-photosynthetic-capacity
#3
Christoph Lehmeier, Radoslaw Pajor, Marjorie R Lundgren, Andrew Mathers, Jen Sloan, Marion Bauch, Alice Mitchell, Chandra Bellasio, Adam Green, Daniel Bouyer, Arp Schnittger, Craig Sturrock, Colin P Osborne, Stephen Rolfe, Sacha Mooney, Andrew J Fleming
The pattern of cell division, growth and separation during leaf development determines the pattern and amount of airspace in a leaf. The resulting balance of cellular material and airspace is expected to significantly influence the primary function of the leaf, photosynthesis, yet the manner and degree to which cell division patterns impact airspace networks and photosynthesis remains largely unexplored. In this paper we investigate the relationship of cell size and patterning, airspace and photosynthesis by promoting and repressing the expression of cell cycle genes in the leaf mesophyll...
September 29, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28899030/mooney-et-al-respond-to-observing-neighborhood-physical-disorder
#4
Stephen J Mooney, Michael D M Bader, Gina S Lovasi, Julien O Teitler, Karestan C Koenen, Allison E Aiello, Sandro Galea, Emily Goldmann, Daniel M Sheehan, Andrew G Rundle
No abstract text is available yet for this article.
August 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28899028/street-audits-to-measure-neighborhood-disorder-virtual-or-in-person
#5
Stephen J Mooney, Michael D M Bader, Gina S Lovasi, Julien O Teitler, Karestan C Koenen, Allison E Aiello, Sandro Galea, Emily Goldmann, Daniel M Sheehan, Andrew G Rundle
Neighborhood conditions may influence a broad range of health indicators, including obesity, injury, and psychopathology. In particular, neighborhood physical disorder-a measure of urban deterioration-is thought to encourage crime and high-risk behaviors, leading to poor mental and physical health. In studies to assess neighborhood physical disorder, investigators typically rely on time-consuming and expensive in-person systematic neighborhood audits. We compared 2 audit-based measures of neighborhood physical disorder in the city of Detroit, Michigan: One used Google Street View imagery from 2009 and the other used an in-person survey conducted in 2008...
August 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28734670/population-health-and-regional-variations-of-disease-burden-in-japan-1990-2015-a-systematic-subnational-analysis-for-the-global-burden-of-disease-study-2015
#6
Shuhei Nomura, Haruka Sakamoto, Scott Glenn, Yusuke Tsugawa, Sarah K Abe, Md M Rahman, Jonathan C Brown, Satoshi Ezoe, Christina Fitzmaurice, Tsuyoshi Inokuchi, Nicholas J Kassebaum, Norito Kawakami, Yosuke Kita, Naoki Kondo, Stephen S Lim, Satoshi Maruyama, Hiroaki Miyata, Meghan D Mooney, Mohsen Naghavi, Tomoko Onoda, Erika Ota, Yuji Otake, Gregory A Roth, Eiko Saito, Takahiro Tabuchi, Yohsuke Takasaki, Tadayuki Tanimura, Manami Uechi, Theo Vos, Haidong Wang, Manami Inoue, Christopher J L Murray, Kenji Shibuya
BACKGROUND: Japan has entered the era of super-ageing and advanced health transition, which is increasingly putting pressure on the sustainability of its health system. The level and pace of this health transition might vary across regions within Japan and concern is growing about increasing regional variations in disease burden. The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) provides a comprehensive, comparable framework. We used data from GBD 2015 with the aim to quantify the burden of disease and injuries, and to attribute risk factors in Japan at a subnational, prefecture-level...
September 23, 2017: Lancet
https://www.readbyqxmd.com/read/28673036/invited-commentary-agent-based-models-bias-in-the-face-of-discovery
#7
COMMENT
Katherine M Keyes, Melissa Tracy, Stephen J Mooney, Aaron Shev, Magdalena Cerdá
Agent-based models (ABMs) have grown in popularity in epidemiologic applications, but the assumptions necessary for valid inference have only partially been articulated. In this issue, Murray et al. (Am J Epidemiol. 2017;186(2):131-142) provided a much-needed analysis of the consequence of some of these assumptions, comparing analysis using an ABM to a similar analysis using the parametric g-formula. In particular, their work focused on the biases that can arise in ABMs that use parameters drawn from distinct populations whose causal structures and baseline outcome risks differ...
July 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28599272/pre-clinical-pharmacology-of-azd3965-a-selective-inhibitor-of-mct1-dlbcl-nhl-and-burkitt-s-lymphoma-anti-tumor-activity
#8
Nicola J Curtis, Lorraine Mooney, Lorna Hopcroft, Filippos Michopoulos, Nichola Whalley, Haihong Zhong, Clare Murray, Armelle Logie, Mitchell Revill, Kate F Byth, Amanda D Benjamin, Mike A Firth, Stephen Green, Paul D Smith, Susan E Critchlow
Tumors frequently display a glycolytic phenotype with increased flux through glycolysis and concomitant synthesis of lactate. To maintain glycolytic flux and prevent intracellular acidification, tumors efflux lactate via lactate transporters (MCT1-4). Inhibitors of lactate transport have the potential to inhibit glycolysis and tumor growth. We developed a small molecule inhibitor of MCT1 (AZD3965) and assessed its activity across a panel of cell lines. We explored its antitumor activity as monotherapy and in combination with doxorubicin or rituximab...
May 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28338912/invited-commentary-the-tao-of-clinical-cohort-analysis-when-the-transitions-that-can-be-spoken-of-are-not-the-true-transitions
#9
COMMENT
Stephen J Mooney
Patterns in risk-related behaviors identified using clinically deployed surveys may hold value for public health surveillance. However, because such surveys assess subjects only when subjects choose to visit clinics, clinical data are subject to variability in observation patterns that is not present in conventional longitudinal data sets in which research teams contact subjects at regular intervals. In this issue of the Journal, Wilkinson et al. (Am J Epidemiol. 2017;185(8):627-635) describe how they applied a latent transition analysis technique to surveillance data collected during clinic visits...
April 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28320836/adaptive-upregulation-of-clumping-factor-a-clfa-by-staphylococcus-aureus-in-the-obese-type-2-diabetic-host-mediates-increased-virulence
#10
Christopher W Farnsworth, Eric M Schott, Sarah E Jensen, Jacob Zukoski, Abigail M Benvie, Majed A Refaai, Stephen L Kates, Edward M Schwarz, Michael J Zuscik, Steven R Gill, Robert A Mooney
Obesity and associated type 2 diabetes (T2D) are important risk factors for infection following orthopedic implant surgery. Staphylococcus aureus, the most common pathogen in bone infections, adapts to multiple environments to survive and evade host immune responses. Whether adaptation of S. aureus to the unique environment of the obese/T2D host accounts for its increased virulence and persistence in this population is unknown. Thus, we assessed implant-associated osteomyelitis in normal versus high-fat-diet obese/T2D mice and found that S...
June 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28154108/contextual-correlates-of-physical-activity-among-older-adults-a-neighborhood-environment-wide-association-study-ne-was
#11
EDITORIAL
Stephen J Mooney, Spruha Joshi, Magdalena Cerdá, Gary J Kennedy, John R Beard, Andrew G Rundle
Background: Few older adults achieve recommended physical activity levels. We conducted a "neighborhood environment-wide association study (NE-WAS)" of neighborhood influences on physical activity among older adults, analogous, in a genetic context, to a genome-wide association study.Methods: Physical Activity Scale for the Elderly (PASE) and sociodemographic data were collected via telephone survey of 3,497 residents of New York City aged 65 to 75 years. Using Geographic Information Systems, we created 337 variables describing each participant's residential neighborhood's built, social, and economic context...
April 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28108872/neighborhood-disorder-and-physical-activity-among-older-adults-a-longitudinal-study
#12
Stephen J Mooney, Spruha Joshi, Magdalena Cerdá, Gary J Kennedy, John R Beard, Andrew G Rundle
Neighborhood physical disorder-the visual indications of neighborhood deterioration-may inhibit outdoor physical activity, particularly among older adults. However, few previous studies of the association between neighborhood disorder and physical activity have focused on this sensitive population group, and most have been cross-sectional. We examined the relationship between neighborhood physical disorder and physical activity, measured using the Physical Activity Scale for the Elderly (PASE), in a three-wave longitudinal study of 3497 New York City residents aged 65-75 at baseline weighted to be representative of the older adult population of New York City...
February 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28096516/newborn-sequencing-in-genomic-medicine-and-public-health
#13
RANDOMIZED CONTROLLED TRIAL
Jonathan S Berg, Pankaj B Agrawal, Donald B Bailey, Alan H Beggs, Steven E Brenner, Amy M Brower, Julie A Cakici, Ozge Ceyhan-Birsoy, Kee Chan, Flavia Chen, Robert J Currier, Dmitry Dukhovny, Robert C Green, Julie Harris-Wai, Ingrid A Holm, Brenda Iglesias, Galen Joseph, Stephen F Kingsmore, Barbara A Koenig, Pui-Yan Kwok, John Lantos, Steven J Leeder, Megan A Lewis, Amy L McGuire, Laura V Milko, Sean D Mooney, Richard B Parad, Stacey Pereira, Joshua Petrikin, Bradford C Powell, Cynthia M Powell, Jennifer M Puck, Heidi L Rehm, Neil Risch, Myra Roche, Joseph T Shieh, Narayanan Veeraraghavan, Michael S Watson, Laurel Willig, Timothy W Yu, Tiina Urv, Anastasia L Wise
The rapid development of genomic sequencing technologies has decreased the cost of genetic analysis to the extent that it seems plausible that genome-scale sequencing could have widespread availability in pediatric care. Genomic sequencing provides a powerful diagnostic modality for patients who manifest symptoms of monogenic disease and an opportunity to detect health conditions before their development. However, many technical, clinical, ethical, and societal challenges should be addressed before such technology is widely deployed in pediatric practice...
February 2017: Pediatrics
https://www.readbyqxmd.com/read/28049071/pathways-from-neighborhood-poverty-to-depression-among-older-adults
#14
Spruha Joshi, Stephen J Mooney, Andrew G Rundle, James W Quinn, John R Beard, Magdalena Cerdá
The pathways through which neighborhood poverty can affect resident depression are still unknown. We investigated mechanisms through which neighborhood poverty may influence depression among older adults. Participants were drawn from the New York City Neighborhood and Mental Health in the Elderly Study II, a 3-wave study of adults aged 65-75 (n=3,497) at baseline. Neighborhood poverty and homicide were associated with depressive symptoms at follow-up waves (RR:1.20, 95%CI: 1.05, 1.36; RR: 1.09, 95%CI: 1.02, 1...
January 2017: Health & Place
https://www.readbyqxmd.com/read/27988140/use-of-mri-in-the-diagnosis-of-fetal-brain-abnormalities-in-utero-meridian-a-multicentre-prospective-cohort-study
#15
Paul D Griffiths, Michael Bradburn, Michael J Campbell, Cindy L Cooper, Ruth Graham, Deborah Jarvis, Mark D Kilby, Gerald Mason, Cara Mooney, Stephen C Robson, Allan Wailoo
BACKGROUND: In-utero MRI (iuMRI) has shown promise as an adjunct to ultrasound but the comparative diagnostic performance has been poorly defined. We aimed to assess whether the diagnostic accuracy and confidence of the prenatal diagnosis of fetal brain abnormalities is improved with iuMRI and assess the clinical impact and patient acceptability of iuMRI. METHODS: We did a multicentre, prospective, cohort study in the UK, at 16 fetal medicine centres, of pregnant women aged 16 years or older whose fetus had a brain abnormality detected by ultrasound at a gestational age of 18 weeks or more, had no contraindications to iuMRI, and consented to enter the study...
February 4, 2017: Lancet
https://www.readbyqxmd.com/read/27787585/cause-and-context-place-based-approaches-to-investigate-how-environments-affect-mental-health
#16
REVIEW
Gina S Lovasi, Stephen J Mooney, Peter Muennig, Charles DiMaggio
OBJECTIVES: Our surroundings affect our mood, our recovery from stress, our behavior, and, ultimately, our mental health. Understanding how our surroundings influence mental health is central to creating healthy cities. However, the traditional observational methods now dominant in the psychiatric epidemiology literature are not sufficient to advance such an understanding. In this essay we consider potential alternative strategies, such as randomizing people to places, randomizing places to change, or harnessing natural experiments that mimic randomized experiments...
December 2016: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/27524819/the-epidemiologic-principles-underlying-traffic-safety-study-designs
#17
REVIEW
June H Kim, Stephen J Mooney
This article describes the epidemiological principles underlying four observational study designs commonly used to assess traffic safety: the case-control, case-crossover, culpability and quasi-induced exposure designs. We focus in particular on the specific challenges for preventing bias using each design. Whereas recruiting controls representative of the source population poses a special challenge in case-control traffic safety studies, case-crossover designs are prone to recall bias, and culpability and quasi-induced exposure studies can be undermined by difficulties assigning crash responsibility...
October 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27482283/neighborhood-physical-disorder-in-new-york-city
#18
James W Quinn, Stephen J Mooney, Daniel M Sheehan, Julien O Teitler, Kathryn M Neckerman, Tanya K Kaufman, Gina S Lovasi, Michael D M Bader, Andrew G Rundle
Neighborhood physical disorder, or the deterioration of urban environments, is associated with negative mental and physical health outcomes. Eleven trained raters used CANVAS, a web-based system for conducting reliable virtual street audits, to collect data on nine indicators of physical disorder using Google Street View imagery of 532 block faces in New York City, New York, USA. We combined the block face indicator data into a disorder scale using item response theory; indicators ranged in severity from presence of litter, a weak indicator of disorder, to abandoned cars, a strong indicator...
2016: Journal of Maps
https://www.readbyqxmd.com/read/27153462/in-the-wrong-place-with-the-wrong-snp-the-association-between-stressful-neighborhoods-and-cardiac-arrest-within-beta-2-adrenergic-receptor-variants
#19
Stephen J Mooney, Stephanie T Grady, Nona Sotoodehnia, Rozenn N Lemaitre, Erin R Wallace, April F Mohanty, Jean Yee, David S Siscovick, Thomas D Rea, Barbara McKnight, Pui-Yan Kwok, Angel C Y Mak, Stephanie Hesselson, Gina S Lovasi
BACKGROUND: Sudden cardiac arrest has been linked independently both to stressful neighborhood conditions and to polymorphisms in the ADRB2 gene. The ADRB2 gene mediates sympathetic activation in response to stress. Therefore, if neighborhood conditions cause cardiac arrest through the stress pathway, the ADRB2 variant may modify the association between neighborhood conditions, such as socioeconomic deprivation and incidence of cardiac arrest. METHODS: The Cardiac Arrest Blood Study Repository is a population-based repository of specimens and other data from adult cardiac arrest patients residing in King County, Washington...
September 2016: Epidemiology
https://www.readbyqxmd.com/read/27148939/cadd-score-has-limited-clinical-validity-for-the-identification-of-pathogenic-variants-in-noncoding-regions-in-a-hereditary-cancer-panel
#20
Cheryl A Mather, Sean D Mooney, Stephen J Salipante, Sheena Scroggins, David Wu, Colin C Pritchard, Brian H Shirts
PURPOSE: Several in silico tools have been shown to have reasonable research sensitivity and specificity for classifying sequence variants in coding regions. The recently developed combined annotation-dependent depletion (CADD) method generates predictive scores for single-nucleotide variants (SNVs) in all areas of the genome, including noncoding regions. We sought for non-coding variants to determine the clinical validity of common CADD scores. METHODS: We evaluated 12,391 unique SNVs in 624 patient samples submitted for germ-line mutation testing in a cancer-related gene panel...
December 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
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