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Stephen J Mooney

Stephen J Mooney
Patterns in risk-related behaviors identified using clinically deployed surveys may hold value for public health surveillance. However, because such surveys assess subjects only when subjects choose to visit clinics, clinical data are subject to variability in observation patterns that is not present in conventional longitudinal data sets in which research teams contact subjects at regular intervals. In this issue of the Journal, Wilkinson et al. (Am J Epidemiol. 2017;185(8):627-635) describe how they applied a latent transition analysis technique to surveillance data collected during clinic visits...
April 15, 2017: American Journal of Epidemiology
Christopher W Farnsworth, Eric M Schott, Sarah E Jensen, Jacob Zukoski, Abigail M Benvie, Majed A Refaai, Stephen L Kates, Edward M Schwarz, Michael J Zuscik, Steven R Gill, Robert A Mooney
Obesity and associated type 2 diabetes (T2D) are important risk factors for infection following orthopaedic implant surgery. Staphylococcus aureus, the most common pathogen in bone infections, adapts to multiple environments to survive and evade host immune responses. Whether adaptation of S. aureus to the unique environment of the obese/T2D host accounts for its increased virulence and persistence in this population is unknown. Thus, we assessed implant-associated osteomyelitis in normal versus high fat-diet obese/T2D mice and found that S...
March 20, 2017: Infection and Immunity
Stephen J Mooney, Spruha Joshi, Magdalena Cerdá, Gary J Kennedy, John R Beard, Andrew G Rundle
Background: Few older adults achieve recommended physical activity levels. We conducted a "neighborhood environment-wide association study (NE-WAS)" of neighborhood influences on physical activity among older adults, analogous, in a genetic context, to a genome-wide association study.Methods: Physical Activity Scale for the Elderly (PASE) and sociodemographic data were collected via telephone survey of 3,497 residents of New York City aged 65 to 75 years. Using Geographic Information Systems, we created 337 variables describing each participant's residential neighborhood's built, social, and economic context...
April 2017: Cancer Epidemiology, Biomarkers & Prevention
Stephen J Mooney, Spruha Joshi, Magdalena Cerdá, Gary J Kennedy, John R Beard, Andrew G Rundle
Neighborhood physical disorder-the visual indications of neighborhood deterioration-may inhibit outdoor physical activity, particularly among older adults. However, few previous studies of the association between neighborhood disorder and physical activity have focused on this sensitive population group, and most have been cross-sectional. We examined the relationship between neighborhood physical disorder and physical activity, measured using the Physical Activity Scale for the Elderly (PASE), in a three-wave longitudinal study of 3497 New York City residents aged 65-75 at baseline weighted to be representative of the older adult population of New York City...
February 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
Jonathan S Berg, Pankaj B Agrawal, Donald B Bailey, Alan H Beggs, Steven E Brenner, Amy M Brower, Julie A Cakici, Ozge Ceyhan-Birsoy, Kee Chan, Flavia Chen, Robert J Currier, Dmitry Dukhovny, Robert C Green, Julie Harris-Wai, Ingrid A Holm, Brenda Iglesias, Galen Joseph, Stephen F Kingsmore, Barbara A Koenig, Pui-Yan Kwok, John Lantos, Steven J Leeder, Megan A Lewis, Amy L McGuire, Laura V Milko, Sean D Mooney, Richard B Parad, Stacey Pereira, Joshua Petrikin, Bradford C Powell, Cynthia M Powell, Jennifer M Puck, Heidi L Rehm, Neil Risch, Myra Roche, Joseph T Shieh, Narayanan Veeraraghavan, Michael S Watson, Laurel Willig, Timothy W Yu, Tiina Urv, Anastasia L Wise
The rapid development of genomic sequencing technologies has decreased the cost of genetic analysis to the extent that it seems plausible that genome-scale sequencing could have widespread availability in pediatric care. Genomic sequencing provides a powerful diagnostic modality for patients who manifest symptoms of monogenic disease and an opportunity to detect health conditions before their development. However, many technical, clinical, ethical, and societal challenges should be addressed before such technology is widely deployed in pediatric practice...
February 2017: Pediatrics
Spruha Joshi, Stephen J Mooney, Andrew G Rundle, James W Quinn, John R Beard, Magdalena Cerdá
The pathways through which neighborhood poverty can affect resident depression are still unknown. We investigated mechanisms through which neighborhood poverty may influence depression among older adults. Participants were drawn from the New York City Neighborhood and Mental Health in the Elderly Study II, a 3-wave study of adults aged 65-75 (n=3,497) at baseline. Neighborhood poverty and homicide were associated with depressive symptoms at follow-up waves (RR:1.20, 95%CI: 1.05, 1.36; RR: 1.09, 95%CI: 1.02, 1...
January 2017: Health & Place
Paul D Griffiths, Michael Bradburn, Michael J Campbell, Cindy L Cooper, Ruth Graham, Deborah Jarvis, Mark D Kilby, Gerald Mason, Cara Mooney, Stephen C Robson, Allan Wailoo
BACKGROUND: In-utero MRI (iuMRI) has shown promise as an adjunct to ultrasound but the comparative diagnostic performance has been poorly defined. We aimed to assess whether the diagnostic accuracy and confidence of the prenatal diagnosis of fetal brain abnormalities is improved with iuMRI and assess the clinical impact and patient acceptability of iuMRI. METHODS: We did a multicentre, prospective, cohort study in the UK, at 16 fetal medicine centres, of pregnant women aged 16 years or older whose fetus had a brain abnormality detected by ultrasound at a gestational age of 18 weeks or more, had no contraindications to iuMRI, and consented to enter the study...
February 4, 2017: Lancet
Gina S Lovasi, Stephen J Mooney, Peter Muennig, Charles DiMaggio
OBJECTIVES: Our surroundings affect our mood, our recovery from stress, our behavior, and, ultimately, our mental health. Understanding how our surroundings influence mental health is central to creating healthy cities. However, the traditional observational methods now dominant in the psychiatric epidemiology literature are not sufficient to advance such an understanding. In this essay we consider potential alternative strategies, such as randomizing people to places, randomizing places to change, or harnessing natural experiments that mimic randomized experiments...
December 2016: Social Psychiatry and Psychiatric Epidemiology
June H Kim, Stephen J Mooney
This article describes the epidemiological principles underlying four observational study designs commonly used to assess traffic safety: the case-control, case-crossover, culpability and quasi-induced exposure designs. We focus in particular on the specific challenges for preventing bias using each design. Whereas recruiting controls representative of the source population poses a special challenge in case-control traffic safety studies, case-crossover designs are prone to recall bias, and culpability and quasi-induced exposure studies can be undermined by difficulties assigning crash responsibility...
August 14, 2016: International Journal of Epidemiology
James W Quinn, Stephen J Mooney, Daniel M Sheehan, Julien O Teitler, Kathryn M Neckerman, Tanya K Kaufman, Gina S Lovasi, Michael D M Bader, Andrew G Rundle
Neighborhood physical disorder, or the deterioration of urban environments, is associated with negative mental and physical health outcomes. Eleven trained raters used CANVAS, a web-based system for conducting reliable virtual street audits, to collect data on nine indicators of physical disorder using Google Street View imagery of 532 block faces in New York City, New York, USA. We combined the block face indicator data into a disorder scale using item response theory; indicators ranged in severity from presence of litter, a weak indicator of disorder, to abandoned cars, a strong indicator...
2016: Journal of Maps
Stephen J Mooney, Stephanie T Grady, Nona Sotoodehnia, Rozenn N Lemaitre, Erin R Wallace, April F Mohanty, Jean Yee, David S Siscovick, Thomas D Rea, Barbara McKnight, Pui-Yan Kwok, Angel C Y Mak, Stephanie Hesselson, Gina S Lovasi
BACKGROUND: Sudden cardiac arrest has been linked independently both to stressful neighborhood conditions and to polymorphisms in the ADRB2 gene. The ADRB2 gene mediates sympathetic activation in response to stress. Therefore, if neighborhood conditions cause cardiac arrest through the stress pathway, the ADRB2 variant may modify the association between neighborhood conditions, such as socioeconomic deprivation and incidence of cardiac arrest. METHODS: The Cardiac Arrest Blood Study Repository is a population-based repository of specimens and other data from adult cardiac arrest patients residing in King County, Washington...
September 2016: Epidemiology
Cheryl A Mather, Sean D Mooney, Stephen J Salipante, Sheena Scroggins, David Wu, Colin C Pritchard, Brian H Shirts
PURPOSE: Several in silico tools have been shown to have reasonable research sensitivity and specificity for classifying sequence variants in coding regions. The recently developed combined annotation-dependent depletion (CADD) method generates predictive scores for single-nucleotide variants (SNVs) in all areas of the genome, including noncoding regions. We sought for non-coding variants to determine the clinical validity of common CADD scores. METHODS: We evaluated 12,391 unique SNVs in 624 patient samples submitted for germ-line mutation testing in a cancer-related gene panel...
December 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Walter Ling, Maureen P Hillhouse, Andrew J Saxon, Larissa J Mooney, Christie M Thomas, Alfonso Ang, Abigail G Matthews, Albert Hasson, Jeffrey Annon, Steve Sparenborg, David S Liu, Jennifer McCormack, Sarah Church, William Swafford, Karen Drexler, Carolyn Schuman, Stephen Ross, Katharina Wiest, P Todd Korthuis, William Lawson, Gregory S Brigham, Patricia C Knox, Michael Dawes, John Rotrosen
AIMS: To examine the safety and effectiveness of buprenorphine + naloxone sublingual tablets (BUP, as Suboxone(®) ) provided after administration of extended-release injectable naltrexone (XR-NTX, as Vivitrol(®) ) to reduce cocaine use in participants who met DSM-IV criteria for cocaine dependence and past or current opioid dependence or abuse. METHODS: This multi-centered, double-blind, placebo-controlled study, conducted under the auspices of the National Drug Abuse Treatment Clinical Trials Network, randomly assigned 302 participants at sites in California, Oregon, Washington, Colorado, Texas, Georgia, Ohio, New York and Washington DC, USA to one of three conditions provided with XR-NTX: 4 mg/day BUP (BUP4, n = 100), 16 mg/day BUP (BUP16, n = 100, or no buprenorphine (placebo; PLB, n = 102)...
August 2016: Addiction
Larissa A Singletary, Joyce E Karlinsey, Stephen J Libby, Jason P Mooney, Kristen L Lokken, Renée M Tsolis, Mariana X Byndloss, Lauren A Hirao, Christopher A Gaulke, Robert W Crawford, Satya Dandekar, Robert A Kingsley, Chisomo L Msefula, Robert S Heyderman, Ferric C Fang
UNLABELLED: Nontyphoidal Salmonella enterica serovar Typhimurium is a frequent cause of bloodstream infections in children and HIV-infected adults in sub-Saharan Africa. Most isolates from African patients with bacteremia belong to a single sequence type, ST313, which is genetically distinct from gastroenteritis-associated ST19 strains, such as 14028s and SL1344. Some studies suggest that the rapid spread of ST313 across sub-Saharan Africa has been facilitated by anthroponotic (person-to-person) transmission, eliminating the need for Salmonella survival outside the host...
March 1, 2016: MBio
Stephen J Mooney, Daniel M Sheehan, Garazi Zulaika, Andrew G Rundle, Kevin McGill, Melika R Behrooz, Gina Schellenbaum Lovasi
OBJECTIVES: To investigate accuracy of distance measures computed from Global Positioning System (GPS) points in New York City. METHODS: We performed structured walks along urban streets carrying Globalsat DG-100 GPS Data Logger devices in highest and lowest quartiles of building height and tree canopy cover. We used ArcGIS version 10.1 to select walks and compute the straight-line distance (Geographic Information System-measured) and sum of distances between consecutive GPS waypoints (GPS-measured) for each walk...
April 2016: American Journal of Public Health
Michael D M Bader, Stephen J Mooney, Andrew G Rundle
No abstract text is available yet for this article.
February 2016: American Journal of Public Health
Stephen J Mooney, Charles J DiMaggio, Gina S Lovasi, Kathryn M Neckerman, Michael D M Bader, Julien O Teitler, Daniel M Sheehan, Darby W Jack, Andrew G Rundle
OBJECTIVES: To demonstrate an information technology-based approach to assess characteristics of streets and intersections associated with injuries that is less costly and time-consuming than location-based studies of pedestrian injury. METHODS: We used imagery captured by Google Street View from 2007 to 2011 to assess 9 characteristics of 532 intersections within New York City. We controlled for estimated pedestrian count and estimated the relation between intersections' characteristics and frequency of injurious collisions...
March 2016: American Journal of Public Health
Spruha Joshi, Stephen J Mooney, Gary J Kennedy, Ebele O Benjamin, Danielle Ompad, Andrew G Rundle, John R Beard, Magdalena Cerdá
BACKGROUND/OBJECTIVES: physical activity may be beneficial in reducing depression incidence among the elderly. A key unanswered question is whether certain types of physical activity are particularly associated with decreased depression incidence. We examined the relationship between quantity and type of physical activity and subsequent depression using longitudinal data from elderly adults in New York City (NYC). METHODS: we followed 3,497 adults aged 65-75 living in NYC for three years...
January 2016: Age and Ageing
Daisuke Hamada, Robert Maynard, Eric Schott, Christopher J Drinkwater, John P Ketz, Stephen L Kates, Jennifer H Jonason, Matthew J Hilton, Michael J Zuscik, Robert A Mooney
OBJECTIVE: Obesity is a state of chronic inflammation that is associated with insulin resistance and type 2 diabetes mellitus (DM), as well as an increased risk of osteoarthritis (OA). This study was undertaken to define the links between obesity-associated inflammation, insulin resistance, and OA, by testing the hypotheses that 1) tumor necrosis factor (TNF) is critical in mediating these pathologic changes in OA, and 2) insulin has direct effects on the synovial joint that are compromised by insulin resistance...
June 2016: Arthritis & Rheumatology
Stephen J Mooney, Abdulrahman M El-Sayed
BACKGROUND: Obesity and depression are comorbid more often than chance predicts. However, depression among the obese is more common in settings where obesity is less common. This suggests that body habitus norms and social stigmatization may play a role in the etiology of depression among the obese. METHODS: We developed an agent-based social network model to explore mechanisms by which deviance from normative body habitus may contribute to social isolation in the obese...
January 2016: Social Science & Medicine
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