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Stephen J Mooney

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https://www.readbyqxmd.com/read/27787585/cause-and-context-place-based-approaches-to-investigate-how-environments-affect-mental-health
#1
REVIEW
Gina S Lovasi, Stephen J Mooney, Peter Muennig, Charles DiMaggio
OBJECTIVES: Our surroundings affect our mood, our recovery from stress, our behavior, and, ultimately, our mental health. Understanding how our surroundings influence mental health is central to creating healthy cities. However, the traditional observational methods now dominant in the psychiatric epidemiology literature are not sufficient to advance such an understanding. In this essay we consider potential alternative strategies, such as randomizing people to places, randomizing places to change, or harnessing natural experiments that mimic randomized experiments...
December 2016: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/27524819/the-epidemiologic-principles-underlying-traffic-safety-study-designs
#2
June H Kim, Stephen J Mooney
This article describes the epidemiological principles underlying four observational study designs commonly used to assess traffic safety: the case-control, case-crossover, culpability and quasi-induced exposure designs. We focus in particular on the specific challenges for preventing bias using each design. Whereas recruiting controls representative of the source population poses a special challenge in case-control traffic safety studies, case-crossover designs are prone to recall bias, and culpability and quasi-induced exposure studies can be undermined by difficulties assigning crash responsibility...
August 14, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27482283/neighborhood-physical-disorder-in-new-york-city
#3
James W Quinn, Stephen J Mooney, Daniel M Sheehan, Julien O Teitler, Kathryn M Neckerman, Tanya K Kaufman, Gina S Lovasi, Michael D M Bader, Andrew G Rundle
Neighborhood physical disorder, or the deterioration of urban environments, is associated with negative mental and physical health outcomes. Eleven trained raters used CANVAS, a web-based system for conducting reliable virtual street audits, to collect data on nine indicators of physical disorder using Google Street View imagery of 532 block faces in New York City, New York, USA. We combined the block face indicator data into a disorder scale using item response theory; indicators ranged in severity from presence of litter, a weak indicator of disorder, to abandoned cars, a strong indicator...
2016: Journal of Maps
https://www.readbyqxmd.com/read/27153462/in-the-wrong-place-with-the-wrong-snp-the-association-between-stressful-neighborhoods-and-cardiac-arrest-within-beta-2-adrenergic-receptor-variants
#4
Stephen J Mooney, Stephanie T Grady, Nona Sotoodehnia, Rozenn N Lemaitre, Erin R Wallace, April F Mohanty, Jean Yee, David S Siscovick, Thomas D Rea, Barbara McKnight, Pui-Yan Kwok, Angel C Y Mak, Stephanie Hesselson, Gina S Lovasi
BACKGROUND: Sudden cardiac arrest has been linked independently both to stressful neighborhood conditions and to polymorphisms in the ADRB2 gene. The ADRB2 gene mediates sympathetic activation in response to stress. Therefore, if neighborhood conditions cause cardiac arrest through the stress pathway, the ADRB2 variant may modify the association between neighborhood conditions, such as socioeconomic deprivation and incidence of cardiac arrest. METHODS: The Cardiac Arrest Blood Study Repository is a population-based repository of specimens and other data from adult cardiac arrest patients residing in King County, Washington...
September 2016: Epidemiology
https://www.readbyqxmd.com/read/27148939/cadd-score-has-limited-clinical-validity-for-the-identification-of-pathogenic-variants-in-noncoding-regions-in-a-hereditary-cancer-panel
#5
Cheryl A Mather, Sean D Mooney, Stephen J Salipante, Sheena Scroggins, David Wu, Colin C Pritchard, Brian H Shirts
PURPOSE: Several in silico tools have been shown to have reasonable research sensitivity and specificity for classifying sequence variants in coding regions. The recently developed combined annotation-dependent depletion (CADD) method generates predictive scores for single-nucleotide variants (SNVs) in all areas of the genome, including noncoding regions. We sought for non-coding variants to determine the clinical validity of common CADD scores. METHODS: We evaluated 12,391 unique SNVs in 624 patient samples submitted for germ-line mutation testing in a cancer-related gene panel...
December 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/26948856/buprenorphine%C3%A2-%C3%A2-naloxone-plus-naltrexone-for-the-treatment-of-cocaine-dependence-the-cocaine-use-reduction-with-buprenorphine-curb-study
#6
Walter Ling, Maureen P Hillhouse, Andrew J Saxon, Larissa J Mooney, Christie M Thomas, Alfonso Ang, Abigail G Matthews, Albert Hasson, Jeffrey Annon, Steve Sparenborg, David S Liu, Jennifer McCormack, Sarah Church, William Swafford, Karen Drexler, Carolyn Schuman, Stephen Ross, Katharina Wiest, P Todd Korthuis, William Lawson, Gregory S Brigham, Patricia C Knox, Michael Dawes, John Rotrosen
AIMS: To examine the safety and effectiveness of buprenorphine + naloxone sublingual tablets (BUP, as Suboxone(®) ) provided after administration of extended-release injectable naltrexone (XR-NTX, as Vivitrol(®) ) to reduce cocaine use in participants who met DSM-IV criteria for cocaine dependence and past or current opioid dependence or abuse. METHODS: This multi-centered, double-blind, placebo-controlled study, conducted under the auspices of the National Drug Abuse Treatment Clinical Trials Network, randomly assigned 302 participants at sites in California, Oregon, Washington, Colorado, Texas, Georgia, Ohio, New York and Washington DC, USA to one of three conditions provided with XR-NTX: 4 mg/day BUP (BUP4, n = 100), 16 mg/day BUP (BUP16, n = 100, or no buprenorphine (placebo; PLB, n = 102)...
August 2016: Addiction
https://www.readbyqxmd.com/read/26933058/loss-of-multicellular-behavior-in-epidemic-african-nontyphoidal-salmonella-enterica-serovar-typhimurium-st313-strain-d23580
#7
Larissa A Singletary, Joyce E Karlinsey, Stephen J Libby, Jason P Mooney, Kristen L Lokken, Renée M Tsolis, Mariana X Byndloss, Lauren A Hirao, Christopher A Gaulke, Robert W Crawford, Satya Dandekar, Robert A Kingsley, Chisomo L Msefula, Robert S Heyderman, Ferric C Fang
UNLABELLED: Nontyphoidal Salmonella enterica serovar Typhimurium is a frequent cause of bloodstream infections in children and HIV-infected adults in sub-Saharan Africa. Most isolates from African patients with bacteremia belong to a single sequence type, ST313, which is genetically distinct from gastroenteritis-associated ST19 strains, such as 14028s and SL1344. Some studies suggest that the rapid spread of ST313 across sub-Saharan Africa has been facilitated by anthroponotic (person-to-person) transmission, eliminating the need for Salmonella survival outside the host...
March 1, 2016: MBio
https://www.readbyqxmd.com/read/26890178/quantifying-distance-overestimation-from-global-positioning-system-in-urban-spaces
#8
Stephen J Mooney, Daniel M Sheehan, Garazi Zulaika, Andrew G Rundle, Kevin McGill, Melika R Behrooz, Gina Schellenbaum Lovasi
OBJECTIVES: To investigate accuracy of distance measures computed from Global Positioning System (GPS) points in New York City. METHODS: We performed structured walks along urban streets carrying Globalsat DG-100 GPS Data Logger devices in highest and lowest quartiles of building height and tree canopy cover. We used ArcGIS version 10.1 to select walks and compute the straight-line distance (Geographic Information System-measured) and sum of distances between consecutive GPS waypoints (GPS-measured) for each walk...
April 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/26794375/protecting-personally-identifiable-information-when-using-online-geographic-tools-for-public-health-research
#9
EDITORIAL
Michael D M Bader, Stephen J Mooney, Andrew G Rundle
No abstract text is available yet for this article.
February 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/26794155/use-of-google-street-view-to-assess-environmental-contributions-to-pedestrian-injury
#10
Stephen J Mooney, Charles J DiMaggio, Gina S Lovasi, Kathryn M Neckerman, Michael D M Bader, Julien O Teitler, Daniel M Sheehan, Darby W Jack, Andrew G Rundle
OBJECTIVES: To demonstrate an information technology-based approach to assess characteristics of streets and intersections associated with injuries that is less costly and time-consuming than location-based studies of pedestrian injury. METHODS: We used imagery captured by Google Street View from 2007 to 2011 to assess 9 characteristics of 532 intersections within New York City. We controlled for estimated pedestrian count and estimated the relation between intersections' characteristics and frequency of injurious collisions...
March 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/26764399/beyond-mets-types-of-physical-activity-and-depression-among-older-adults
#11
Spruha Joshi, Stephen J Mooney, Gary J Kennedy, Ebele O Benjamin, Danielle Ompad, Andrew G Rundle, John R Beard, Magdalena Cerdá
BACKGROUND/OBJECTIVES: physical activity may be beneficial in reducing depression incidence among the elderly. A key unanswered question is whether certain types of physical activity are particularly associated with decreased depression incidence. We examined the relationship between quantity and type of physical activity and subsequent depression using longitudinal data from elderly adults in New York City (NYC). METHODS: we followed 3,497 adults aged 65-75 living in NYC for three years...
January 2016: Age and Ageing
https://www.readbyqxmd.com/read/26713606/suppressive-effects-of-insulin-on-tumor-necrosis-factor-dependent-early-osteoarthritic-changes-associated-with-obesity-and-type-2-diabetes-mellitus
#12
Daisuke Hamada, Robert Maynard, Eric Schott, Christopher J Drinkwater, John P Ketz, Stephen L Kates, Jennifer H Jonason, Matthew J Hilton, Michael J Zuscik, Robert A Mooney
OBJECTIVE: Obesity is a state of chronic inflammation that is associated with insulin resistance and type 2 diabetes mellitus (DM), as well as an increased risk of osteoarthritis (OA). This study was undertaken to define the links between obesity-associated inflammation, insulin resistance, and OA, by testing the hypotheses that 1) tumor necrosis factor (TNF) is critical in mediating these pathologic changes in OA, and 2) insulin has direct effects on the synovial joint that are compromised by insulin resistance...
June 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/26638142/stigma-and-the-etiology-of-depression-among-the-obese-an-agent-based-exploration
#13
Stephen J Mooney, Abdulrahman M El-Sayed
BACKGROUND: Obesity and depression are comorbid more often than chance predicts. However, depression among the obese is more common in settings where obesity is less common. This suggests that body habitus norms and social stigmatization may play a role in the etiology of depression among the obese. METHODS: We developed an agent-based social network model to explore mechanisms by which deviance from normative body habitus may contribute to social isolation in the obese...
January 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/26415002/3d-printed-microtransporters-compound-micromachines-for-spatiotemporally-controlled-delivery-of-therapeutic-agents
#14
Tian-Yun Huang, Mahmut Selman Sakar, Angelo Mao, Andrew J Petruska, Famin Qiu, Xue-Bo Chen, Stephen Kennedy, David Mooney, Bradley J Nelson
Functional compound micromachines are fabricated by a design methodology using 3D direct laser writing and selective physical vapor deposition of magnetic materials. Microtransporters with a wirelessly controlled Archimedes screw pumping mechanism are engineered. Spatiotemporally controlled collection, transport, and delivery of micro particles, as well as magnetic nanohelices inside microfluidic channels are demonstrated.
November 2015: Advanced Materials
https://www.readbyqxmd.com/read/26366739/transient-loss-of-protection-afforded-by-a-live-attenuated-non-typhoidal-salmonella-vaccine-in-mice-co-infected-with-malaria
#15
Jason P Mooney, Seung-Joo Lee, Kristen L Lokken, Minelva R Nanton, Sean-Paul Nuccio, Stephen J McSorley, Renée M Tsolis
In immunocompetent individuals, non-typhoidal Salmonella serovars (NTS) are associated with gastroenteritis, however, there is currently an epidemic of NTS bloodstream infections in sub-Saharan Africa. Plasmodium falciparum malaria is an important risk factor for invasive NTS bloodstream in African children. Here we investigated whether a live, attenuated Salmonella vaccine could be protective in mice, in the setting of concurrent malaria. Surprisingly, mice acutely infected with the nonlethal malaria parasite Plasmodium yoelii 17XNL exhibited a profound loss of protective immunity to NTS, but vaccine-mediated protection was restored after resolution of malaria...
2015: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/26321261/global-regional-and-national-disability-adjusted-life-years-dalys-for-306-diseases-and-injuries-and-healthy-life-expectancy-hale-for-188-countries-1990-2013-quantifying-the-epidemiological-transition
#16
Christopher J L Murray, Ryan M Barber, Kyle J Foreman, Ayse Abbasoglu Ozgoren, Foad Abd-Allah, Semaw F Abera, Victor Aboyans, Jerry P Abraham, Ibrahim Abubakar, Laith J Abu-Raddad, Niveen M Abu-Rmeileh, Tom Achoki, Ilana N Ackerman, Zanfina Ademi, Arsène K Adou, José C Adsuar, Ashkan Afshin, Emilie E Agardh, Sayed Saidul Alam, Deena Alasfoor, Mohammed I Albittar, Miguel A Alegretti, Zewdie A Alemu, Rafael Alfonso-Cristancho, Samia Alhabib, Raghib Ali, François Alla, Peter Allebeck, Mohammad A Almazroa, Ubai Alsharif, Elena Alvarez, Nelson Alvis-Guzman, Azmeraw T Amare, Emmanuel A Ameh, Heresh Amini, Walid Ammar, H Ross Anderson, Benjamin O Anderson, Carl Abelardo T Antonio, Palwasha Anwari, Johan Arnlöv, Valentina S Arsic Arsenijevic, Al Artaman, Rana J Asghar, Reza Assadi, Lydia S Atkins, Marco A Avila, Baffour Awuah, Victoria F Bachman, Alaa Badawi, Maria C Bahit, Kalpana Balakrishnan, Amitava Banerjee, Suzanne L Barker-Collo, Simon Barquera, Lars Barregard, Lope H Barrero, Arindam Basu, Sanjay Basu, Mohammed O Basulaiman, Justin Beardsley, Neeraj Bedi, Ettore Beghi, Tolesa Bekele, Michelle L Bell, Corina Benjet, Derrick A Bennett, Isabela M Bensenor, Habib Benzian, Eduardo Bernabé, Amelia Bertozzi-Villa, Tariku J Beyene, Neeraj Bhala, Ashish Bhalla, Zulfiqar A Bhutta, Kelly Bienhoff, Boris Bikbov, Stan Biryukov, Jed D Blore, Christopher D Blosser, Fiona M Blyth, Megan A Bohensky, Ian W Bolliger, Berrak Bora Başara, Natan M Bornstein, Dipan Bose, Soufiane Boufous, Rupert R A Bourne, Lindsay N Boyers, Michael Brainin, Carol E Brayne, Alexandra Brazinova, Nicholas J K Breitborde, Hermann Brenner, Adam D Briggs, Peter M Brooks, Jonathan C Brown, Traolach S Brugha, Rachelle Buchbinder, Geoffrey C Buckle, Christine M Budke, Anne Bulchis, Andrew G Bulloch, Ismael R Campos-Nonato, Hélène Carabin, Jonathan R Carapetis, Rosario Cárdenas, David O Carpenter, Valeria Caso, Carlos A Castañeda-Orjuela, Ruben E Castro, Ferrán Catalá-López, Fiorella Cavalleri, Alanur Çavlin, Vineet K Chadha, Jung-Chen Chang, Fiona J Charlson, Honglei Chen, Wanqing Chen, Peggy P Chiang, Odgerel Chimed-Ochir, Rajiv Chowdhury, Hanne Christensen, Costas A Christophi, Massimo Cirillo, Matthew M Coates, Luc E Coffeng, Megan S Coggeshall, Valentina Colistro, Samantha M Colquhoun, Graham S Cooke, Cyrus Cooper, Leslie T Cooper, Luis M Coppola, Monica Cortinovis, Michael H Criqui, John A Crump, Lucia Cuevas-Nasu, Hadi Danawi, Lalit Dandona, Rakhi Dandona, Emily Dansereau, Paul I Dargan, Gail Davey, Adrian Davis, Dragos V Davitoiu, Anand Dayama, Diego De Leo, Louisa Degenhardt, Borja Del Pozo-Cruz, Robert P Dellavalle, Kebede Deribe, Sarah Derrett, Don C Des Jarlais, Muluken Dessalegn, Samath D Dharmaratne, Mukesh K Dherani, Cesar Diaz-Torné, Daniel Dicker, Eric L Ding, Klara Dokova, E Ray Dorsey, Tim R Driscoll, Leilei Duan, Herbert C Duber, Beth E Ebel, Karen M Edmond, Yousef M Elshrek, Matthias Endres, Sergey P Ermakov, Holly E Erskine, Babak Eshrati, Alireza Esteghamati, Kara Estep, Emerito Jose A Faraon, Farshad Farzadfar, Derek F Fay, Valery L Feigin, David T Felson, Seyed-Mohammad Fereshtehnejad, Jefferson G Fernandes, Alize J Ferrari, Christina Fitzmaurice, Abraham D Flaxman, Thomas D Fleming, Nataliya Foigt, Mohammad H Forouzanfar, F Gerry R Fowkes, Urbano Fra Paleo, Richard C Franklin, Thomas Fürst, Belinda Gabbe, Lynne Gaffikin, Fortuné G Gankpé, Johanna M Geleijnse, Bradford D Gessner, Peter Gething, Katherine B Gibney, Maurice Giroud, Giorgia Giussani, Hector Gomez Dantes, Philimon Gona, Diego González-Medina, Richard A Gosselin, Carolyn C Gotay, Atsushi Goto, Hebe N Gouda, Nicholas Graetz, Harish C Gugnani, Rahul Gupta, Rajeev Gupta, Reyna A Gutiérrez, Juanita Haagsma, Nima Hafezi-Nejad, Holly Hagan, Yara A Halasa, Randah R Hamadeh, Hannah Hamavid, Mouhanad Hammami, Jamie Hancock, Graeme J Hankey, Gillian M Hansen, Yuantao Hao, Hilda L Harb, Josep Maria Haro, Rasmus Havmoeller, Simon I Hay, Roderick J Hay, Ileana B Heredia-Pi, Kyle R Heuton, Pouria Heydarpour, Hideki Higashi, Martha Hijar, Hans W Hoek, Howard J Hoffman, H Dean Hosgood, Mazeda Hossain, Peter J Hotez, Damian G Hoy, Mohamed Hsairi, Guoqing Hu, Cheng Huang, John J Huang, Abdullatif Husseini, Chantal Huynh, Marissa L Iannarone, Kim M Iburg, Kaire Innos, Manami Inoue, Farhad Islami, Kathryn H Jacobsen, Deborah L Jarvis, Simerjot K Jassal, Sun Ha Jee, Panniyammakal Jeemon, Paul N Jensen, Vivekanand Jha, Guohong Jiang, Ying Jiang, Jost B Jonas, Knud Juel, Haidong Kan, André Karch, Corine K Karema, Chante Karimkhani, Ganesan Karthikeyan, Nicholas J Kassebaum, Anil Kaul, Norito Kawakami, Konstantin Kazanjan, Andrew H Kemp, Andre P Kengne, Andre Keren, Yousef S Khader, Shams Eldin A Khalifa, Ejaz A Khan, Gulfaraz Khan, Young-Ho Khang, Christian Kieling, Daniel Kim, Sungroul Kim, Yunjin Kim, Yohannes Kinfu, Jonas M Kinge, Miia Kivipelto, Luke D Knibbs, Ann Kristin Knudsen, Yoshihiro Kokubo, Soewarta Kosen, Sanjay Krishnaswami, Barthelemy Kuate Defo, Burcu Kucuk Bicer, Ernst J Kuipers, Chanda Kulkarni, Veena S Kulkarni, G Anil Kumar, Hmwe H Kyu, Taavi Lai, Ratilal Lalloo, Tea Lallukka, Hilton Lam, Qing Lan, Van C Lansingh, Anders Larsson, Alicia E B Lawrynowicz, Janet L Leasher, James Leigh, Ricky Leung, Carly E Levitz, Bin Li, Yichong Li, Yongmei Li, Stephen S Lim, Maggie Lind, Steven E Lipshultz, Shiwei Liu, Yang Liu, Belinda K Lloyd, Katherine T Lofgren, Giancarlo Logroscino, Katharine J Looker, Joannie Lortet-Tieulent, Paulo A Lotufo, Rafael Lozano, Robyn M Lucas, Raimundas Lunevicius, Ronan A Lyons, Stefan Ma, Michael F Macintyre, Mark T Mackay, Marek Majdan, Reza Malekzadeh, Wagner Marcenes, David J Margolis, Christopher Margono, Melvin B Marzan, Joseph R Masci, Mohammad T Mashal, Richard Matzopoulos, Bongani M Mayosi, Tasara T Mazorodze, Neil W Mcgill, John J Mcgrath, Martin Mckee, Abigail Mclain, Peter A Meaney, Catalina Medina, Man Mohan Mehndiratta, Wubegzier Mekonnen, Yohannes A Melaku, Michele Meltzer, Ziad A Memish, George A Mensah, Atte Meretoja, Francis A Mhimbira, Renata Micha, Ted R Miller, Edward J Mills, Philip B Mitchell, Charles N Mock, Norlinah Mohamed Ibrahim, Karzan A Mohammad, Ali H Mokdad, Glen L D Mola, Lorenzo Monasta, Julio C Montañez Hernandez, Marcella Montico, Thomas J Montine, Meghan D Mooney, Ami R Moore, Maziar Moradi-Lakeh, Andrew E Moran, Rintaro Mori, Joanna Moschandreas, Wilkister N Moturi, Madeline L Moyer, Dariush Mozaffarian, William T Msemburi, Ulrich O Mueller, Mitsuru Mukaigawara, Erin C Mullany, Michele E Murdoch, Joseph Murray, Kinnari S Murthy, Mohsen Naghavi, Aliya Naheed, Kovin S Naidoo, Luigi Naldi, Devina Nand, Vinay Nangia, K M Venkat Narayan, Chakib Nejjari, Sudan P Neupane, Charles R Newton, Marie Ng, Frida N Ngalesoni, Grant Nguyen, Muhammad I Nisar, Sandra Nolte, Ole F Norheim, Rosana E Norman, Bo Norrving, Luke Nyakarahuka, In-Hwan Oh, Takayoshi Ohkubo, Summer L Ohno, Bolajoko O Olusanya, John Nelson Opio, Katrina Ortblad, Alberto Ortiz, Amanda W Pain, Jeyaraj D Pandian, Carlo Irwin A Panelo, Christina Papachristou, Eun-Kee Park, Jae-Hyun Park, Scott B Patten, George C Patton, Vinod K Paul, Boris I Pavlin, Neil Pearce, David M Pereira, Rogelio Perez-Padilla, Fernando Perez-Ruiz, Norberto Perico, Aslam Pervaiz, Konrad Pesudovs, Carrie B Peterson, Max Petzold, Michael R Phillips, Bryan K Phillips, David E Phillips, Frédéric B Piel, Dietrich Plass, Dan Poenaru, Suzanne Polinder, Daniel Pope, Svetlana Popova, Richie G Poulton, Farshad Pourmalek, Dorairaj Prabhakaran, Noela M Prasad, Rachel L Pullan, Dima M Qato, D Alex Quistberg, Anwar Rafay, Kazem Rahimi, Sajjad U Rahman, Murugesan Raju, Saleem M Rana, Homie Razavi, K Srinath Reddy, Amany Refaat, Giuseppe Remuzzi, Serge Resnikoff, Antonio L Ribeiro, Lee Richardson, Jan Hendrik Richardus, D Allen Roberts, David Rojas-Rueda, Luca Ronfani, Gregory A Roth, Dietrich Rothenbacher, David H Rothstein, Jane T Rowley, Nobhojit Roy, George M Ruhago, Mohammad Y Saeedi, Sukanta Saha, Mohammad Ali Sahraian, Uchechukwu K A Sampson, Juan R Sanabria, Logan Sandar, Itamar S Santos, Maheswar Satpathy, Monika Sawhney, Peter Scarborough, Ione J Schneider, Ben Schöttker, Austin E Schumacher, David C Schwebel, James G Scott, Soraya Seedat, Sadaf G Sepanlou, Peter T Serina, Edson E Servan-Mori, Katya A Shackelford, Amira Shaheen, Saeid Shahraz, Teresa Shamah Levy, Siyi Shangguan, Jun She, Sara Sheikhbahaei, Peilin Shi, Kenji Shibuya, Yukito Shinohara, Rahman Shiri, Kawkab Shishani, Ivy Shiue, Mark G Shrime, Inga D Sigfusdottir, Donald H Silberberg, Edgar P Simard, Shireen Sindi, Abhishek Singh, Jasvinder A Singh, Lavanya Singh, Vegard Skirbekk, Erica Leigh Slepak, Karen Sliwa, Samir Soneji, Kjetil Søreide, Sergey Soshnikov, Luciano A Sposato, Chandrashekhar T Sreeramareddy, Jeffrey D Stanaway, Vasiliki Stathopoulou, Dan J Stein, Murray B Stein, Caitlyn Steiner, Timothy J Steiner, Antony Stevens, Andrea Stewart, Lars J Stovner, Konstantinos Stroumpoulis, Bruno F Sunguya, Soumya Swaminathan, Mamta Swaroop, Bryan L Sykes, Karen M Tabb, Ken Takahashi, Nikhil Tandon, David Tanne, Marcel Tanner, Mohammad Tavakkoli, Hugh R Taylor, Braden J Te Ao, Fabrizio Tediosi, Awoke M Temesgen, Tara Templin, Margreet Ten Have, Eric Y Tenkorang, Abdullah S Terkawi, Blake Thomson, Andrew L Thorne-Lyman, Amanda G Thrift, George D Thurston, Taavi Tillmann, Marcello Tonelli, Fotis Topouzis, Hideaki Toyoshima, Jefferson Traebert, Bach X Tran, Matias Trillini, Thomas Truelsen, Miltiadis Tsilimbaris, Emin M Tuzcu, Uche S Uchendu, Kingsley N Ukwaja, Eduardo A Undurraga, Selen B Uzun, Wim H Van Brakel, Steven Van De Vijver, Coen H van Gool, Jim Van Os, Tommi J Vasankari, N Venketasubramanian, Francesco S Violante, Vasiliy V Vlassov, Stein Emil Vollset, Gregory R Wagner, Joseph Wagner, Stephen G Waller, Xia Wan, Haidong Wang, Jianli Wang, Linhong Wang, Tati S Warouw, Scott Weichenthal, Elisabete Weiderpass, Robert G Weintraub, Wang Wenzhi, Andrea Werdecker, Ronny Westerman, Harvey A Whiteford, James D Wilkinson, Thomas N Williams, Charles D Wolfe, Timothy M Wolock, Anthony D Woolf, Sarah Wulf, Brittany Wurtz, Gelin Xu, Lijing L Yan, Yuichiro Yano, Pengpeng Ye, Gökalp K Yentür, Paul Yip, Naohiro Yonemoto, Seok-Jun Yoon, Mustafa Z Younis, Chuanhua Yu, Maysaa E Zaki, Yong Zhao, Yingfeng Zheng, David Zonies, Xiaonong Zou, Joshua A Salomon, Alan D Lopez, Theo Vos
BACKGROUND: The Global Burden of Disease Study 2013 (GBD 2013) aims to bring together all available epidemiological data using a coherent measurement framework, standardised estimation methods, and transparent data sources to enable comparisons of health loss over time and across causes, age-sex groups, and countries. The GBD can be used to generate summary measures such as disability-adjusted life-years (DALYs) and healthy life expectancy (HALE) that make possible comparative assessments of broad epidemiological patterns across countries and time...
November 28, 2015: Lancet
https://www.readbyqxmd.com/read/26091927/patterns-of-physical-activity-among-older-adults-in-new-york-city-a-latent-class-approach
#17
Stephen J Mooney, Spruha Joshi, Magdalena Cerdá, James W Quinn, John R Beard, Gary J Kennedy, Ebele O Benjamin, Danielle C Ompad, Andrew G Rundle
INTRODUCTION: Little research to date has explored typologies of physical activity among older adults. An understanding of physical activity patterns may help to both determine the health benefits of different types of activity and target interventions to increase activity levels in older adults. This analysis, conducted in 2014, used a latent class analysis approach to characterize patterns of physical activity in a cohort of older adults. METHODS: A total of 3,497 men and women aged 65-75 years living in New York City completed the Physical Activity Scale for the Elderly (PASE) in 2011...
September 2015: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/26069025/prenatal-exposure-to-phthalates-and-childhood-body-size-in-an-urban-cohort
#18
Michelle M Maresca, Lori A Hoepner, Abeer Hassoun, Sharon E Oberfield, Stephen J Mooney, Antonia M Calafat, Judyth Ramirez, Greg Freyer, Frederica P Perera, Robin M Whyatt, Andrew G Rundle
BACKGROUND: Phthalate exposures are hypothesized to increase obesity; however, prior research has been largely cross-sectional. OBJECTIVE: We evaluated associations between prenatal phthalate exposures and body mass index (BMI) at child ages 5 and 7 years. METHODS: Nine metabolites of six phthalates-di(2-ethylhexyl) phthalate (DEHP), di-n-octyl-, di-iso-butyl-, di-n-butyl-, butylbenzyl-, and diethyl phthalates-were measured in spot urine samples collected from pregnant African-American and Dominican women during their third trimester, and from their children at ages 3 and 5 years...
April 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/26044285/switchable-release-of-entrapped-nanoparticles-from-alginate-hydrogels
#19
Cathal J Kearney, Hadas Skaat, Stephen M Kennedy, Jennifer Hu, Max Darnell, Theresa M Raimondo, David J Mooney
Natural biological processes are intricately controlled by the timing and spatial distribution of various cues. To mimic this precise level of control, the physical sizes of gold nanoparticles are utilized to sterically entrap them in hydrogel materials, where they are subsequently released only in response to ultrasound. These nanoparticles can transport bioactive factors to cells and direct cell behavior on-demand.
August 5, 2015: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/25923415/mathematical-modelling-of-metabolic-regulation-in-aging
#20
REVIEW
Mark T Mc Auley, Kathleen M Mooney, Peter J Angell, Stephen J Wilkinson
The underlying cellular mechanisms that characterize aging are complex and multifaceted. However, it is emerging that aging could be regulated by two distinct metabolic hubs. These hubs are the pathway defined by the mammalian target of rapamycin (mTOR) and that defined by the NAD+-dependent deacetylase enzyme, SIRT1. Recent experimental evidence suggests that there is crosstalk between these two important pathways; however, the mechanisms underpinning their interaction(s) remains poorly understood. In this review, we propose using computational modelling in tandem with experimentation to delineate the mechanism(s)...
2015: Metabolites
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