keyword
MENU ▼
Read by QxMD icon Read
search

hanny

keyword
https://www.readbyqxmd.com/read/28734148/apathy-in-early-and-late-life-depression
#1
Isis Groeneweg-Koolhoven, Merel Ploeg, Hannie C Comijs, Brenda Wjh Penninx, Roos C van der Mast, Robert A Schoevers, Didi Rhebergen, Eric van Exel
BACKGROUND: Late-life depression is thought to differ in clinical presentation from early-life depression. Particularly, late-life depression is considered to be more characterized by apathy than is early-life depression. Lacking convincing evidence, this study examines the presence and associated socio-demographic/clinical characteristics of apathy in older compared to younger depressed persons. METHODS: This cross-sectional study used data from two naturalistic cohort studies, i...
July 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28705099/heat-induced-brca2-degradation-in-human-tumors-provides-rationale-for-hyperthermia-parp-inhibitor-combination-therapies
#2
Nathalie van den Tempel, Hanny Odijk, Netteke van Holthe, Kishan Naipal, Anja Raams, Berina Eppink, Dik van Gent, Jose Hardillo, Gerda Verduijn, Jan Drooger, Gerard van Rhoon, Dineke Smedts, Helena van Doorn, Joost Boormans, Agnes Jager, Martine Franckena, Roland Kanaar
PURPOSE: Hyperthermia (40-44°C) effectively sensitizes tumors to radiotherapy by locally altering tumor biology. One of the effects of heat at the cellular level is inhibition of DNA repair by homologous recombination via degradation of the BRCA2-protein. This suggests that hyperthermia can expand the group of patients that benefit from PARP-inhibitors, a drug exploiting homologous recombination deficiency. Here, we explore whether the molecular mechanisms that cause heat-mediated degradation of BRCA2 are conserved in cell lines from various origins and, most importantly, whether, BRCA2 protein levels can be attenuated by heat in freshly biopted human tumors...
July 13, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28662435/comparison-of-internet-and-mailing-methods-to-recruit-couples-into-research-on-unaided-smoking-cessation
#3
Jaye L Derrick, Rebecca K Eliseo-Arras, Courtney Hanny, Maggie Britton, Sana Haddad
In smoking cessation studies with restrictive criteria (e.g., single-smoker couples), thousands of potential participants might need to be screened to obtain a reasonable sample size. Consideration of recruitment methodology is critical because recruitment methods influence both the success and cost effectiveness of recruitment. Although traditional recruitment methods are often used to recruit participants into smoking cessation research, newer technologies, such as paid Facebook advertising, might offer more cost-effective alternatives for recruitment...
June 21, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28652559/expression-of-thyroid-hormone-regulator-genes-in-the-yolk-sac-membrane-of-the-developing-chicken-embryo
#4
Hanny Cho Too, Mitsuhiro Shibata, Masato Yayota, Veerle M Darras, Atsushi Iwasawa
Thyroid hormones (THs) are essential for the correct development of nearly every structure in the body from the very early stages of development, yet the embryonic thyroid gland is not functional at these stages. To clarify the roles of the egg yolk as a source of THs, the TH content in the yolk and the expression of TH regulator genes in the yolk sac membrane were evaluated throughout the 21-day incubation period of chicken embryos. The yolk TH content (22.3 ng triiodothyronine and 654.7 ng thyroxine per total yolk on day 4 of incubation) decreased almost linearly along with development...
June 25, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/28618114/subjective-insomnia-symptoms-and-sleep-duration-are-not-related-to-hypothalamic-pituitary-adrenal-axis-activity-in-older-adults
#5
Rian J G Peters van Neijenhof, Erik van Duijn, Julia F Van Den Berg, Margot W M de Waal, Roos C van der Mast, Hannie C Comijs
Insomnia symptoms are highly prevalent in depressed older adults. This study investigates the association between hypothalamic-pituitary-adrenal (HPA) axis activity and symptoms of insomnia, respectively, sleep duration among 294 depressed and 123 non-depressed older adults of the Netherlands Study of Depression in Older people (NESDO) study. Insomnia symptoms were defined as clinically relevant when having a score ≥ 10 points on the Women's Health Initiative Insomnia Rating Scale (WHIIRS). Sleep duration was categorized in short (≤ 6 h per night), normal (7-8 h per night) and long (≥ 9 h per night) duration...
June 15, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28609340/effect-of-interscalene-brachial-plexus-block-on-the-pulmonary-function-of-obese-patients-a-prospective-observational-cohort-study
#6
M Stephen Melton, Hanni E Monroe, Wenjing Qi, Stephanie L Lewis, Karen C Nielsen, Stephen M Klein
BACKGROUND: The effect of interscalene block (ISB) on pulmonary function of obese participants has not been investigated. The goal of this study is to assess the association of obesity (body mass index [BMI] >29 kg/m vs BMI <25 kg/m) and change in forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) after ISB in participants undergoing outpatient shoulder surgery. METHODS: This prospective, observational cohort study compared obese (BMI >29 kg/m) and normal-weight (BMI <25 kg/m) groups undergoing ISB for ambulatory shoulder surgery, on preblock and postblock FVC and FEV1, at 30 minutes postblock and in the postanesthesia care unit (PACU)...
July 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28606505/the-relationship-between-serum-25-oh-d-levels-and-anxiety-symptoms-in-older-persons-results-from-the-longitudinal-aging-study-amsterdam
#7
Elisa J de Koning, Lotte Verweij, Paul Lips, Aartjan T F Beekman, Hannie C Comijs, Natasja M van Schoor
OBJECTIVE: Low serum 25-hydroxyvitamin D levels (25(OH)D<50nmol/L) are common in older persons and associated with depressive symptoms. Depression and anxiety are highly interrelated, but only very few studies examined the association between 25(OH)D and anxiety. This study investigated whether 25(OH)D levels are related to anxiety symptoms in older persons, both cross-sectionally and over time. METHODS: Data from two samples of a large population-based cohort study were used (sample 1: N=1259, 64-88years; sample 2: N=892, 60-98years)...
June 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28590857/public-health-research-priorities-to-address-us-human-trafficking
#8
Emily F Rothman, Hanni Stoklosa, Susie B Baldwin, Makini Chisolm-Straker, Rumi Kato Price, Holly G Atkinson
No abstract text is available yet for this article.
July 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28579933/changes-in-admission-to-long-term-care-institutions-in-the-netherlands-comparing-two-cohorts-over-the-period-1996-1999-and-2006-2009
#9
Peter Alders, Hannie C Comijs, Dorly J H Deeg
Using data from two cohorts, we examine to what extent a decline in institutional care in the Netherlands is associated with changes in the need for care and/or societal factors. We compared older adults, aged 65-89, who were admitted to a long-term care (LTC) institution in the period 1996-1999 and 2006-2009. Using the Andersen model, we tested per block of predisposing, enabling and need factors, which factors were significant predictors of admission to institutional care. With a Blinder-Oaxaca decomposition regression, we decomposed the difference in admission to an LTC institution between the period 1996-1999 and 2006-2009 into a part that is due to differences in health needs and other factors such as effect of policy, social values, and technology...
June 2017: European Journal of Ageing
https://www.readbyqxmd.com/read/28575323/darunavir-concentrations-in-csf-of-hiv-infected-individuals-when-boosted-with-cobicistat-versus-ritonavir
#10
Hanni Bartels, Laurent Decosterd, Manuel Battegay, Catia Marzolini
Objectives: Cobicistat and ritonavir have different inhibitory profiles for drug transporters that could impact the distribution of co-administered drugs. We compared darunavir concentrations in CSF when boosted by cobicistat versus ritonavir relative to plasma concentrations and with WT HIV-1 IC 50 and IC 90 . Methods: An open, single-arm, sequential clinical trial (NCT02503462) where paired CSF and blood samples were taken from seven HIV-infected patients presenting with HIV-associated neurocognitive disorders (HAND) and treated with a darunavir/ritonavir (800/100 mg) once-daily regimen...
June 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28574821/the-effect-of-thermal-dose-on-hyperthermia-mediated-inhibition-of-dna-repair-through-homologous-recombination
#11
Nathalie van den Tempel, Charlie Laffeber, Hanny Odijk, Wiggert A van Cappellen, Gerard C van Rhoon, Martine Franckena, Roland Kanaar
Hyperthermia has a number of biological effects that sensitize tumors to radiotherapy in the range between 40-44 °C. One of these effects is heat-induced degradation of BRCA2 that in turn causes reduced RAD51 focus formation, which results in an attenuation of DNA repair through homologous recombination. Prompted by this molecular insight into how hyperthermia attenuates homologous recombination, we now quantitatively explore time and temperature dynamics of hyperthermia on BRCA2 levels and RAD51 focus formation in cell culture models, and link this to their clonogenic survival capacity after irradiation (0-6 Gy)...
July 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28554154/admixture-analysis-of-age-of-onset-in-generalized-anxiety-disorder
#12
Didi Rhebergen, Idan M Aderka, Ira M van der Steenstraten, Anton J L M van Balkom, Patricia van Oppen, Max L Stek, Hannie C Comijs, Neeltje M Batelaan
Age of onset is a marker of clinically relevant subtypes in various medical and psychiatric disorders. Past research has also reported that age of onset in generalized anxiety disorder (GAD) is clinically significant; but, in research to date, arbitrary cut-off ages have been used. In the present study, admixture analysis was used to determine the best fitting model for age of onset distribution in GAD. Data were derived from 459 adults with a diagnosis of GAD who took part in the Netherlands Study of Depression and Anxiety (NESDA)...
May 10, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28546720/dermatofibrosarcoma-protruberans-of-the-breast-skin-simulating-mammary-carcinoma
#13
Prakriti Shukla, Hanni Vasudev Gulwani
Dermatofibrosarcoma protuberans is a rare soft tissue sarcoma that arises from the dermis and invades deeper tissues. Usually, it behaves as an intermediate grade malignancy but in rare instances, it can metastasize. Frequent occurrences have been observed in trunk and extremities but involvement of the breast has rarely been reported. Therefore, dermatofibrosarcoma protuberans (DFSP) breast often masquerades primary breast malignancy on clinical and radiological grounds. Histomorphology and immunohistochemistry are helpful in making a definitive diagnosis...
June 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28542229/thermodynamic-framework-to-assess-low-abundance-dna-mutation-detection-by-hybridization
#14
Hanny Willems, An Jacobs, Wahyu Wijaya Hadiwikarta, Tom Venken, Dirk Valkenborg, Nadine Van Roy, Jo Vandesompele, Jef Hooyberghs
The knowledge of genomic DNA variations in patient samples has a high and increasing value for human diagnostics in its broadest sense. Although many methods and sensors to detect or quantify these variations are available or under development, the number of underlying physico-chemical detection principles is limited. One of these principles is the hybridization of sample target DNA versus nucleic acid probes. We introduce a novel thermodynamics approach and develop a framework to exploit the specific detection capabilities of nucleic acid hybridization, using generic principles applicable to any platform...
2017: PloS One
https://www.readbyqxmd.com/read/28529500/co-existence-of-methanogenesis-and-sulfate-reduction-with-common-substrates-in-sulfate-rich-estuarine-sediments
#15
Michal Sela-Adler, Zeev Ronen, Barak Herut, Gilad Antler, Hanni Vigderovich, Werner Eckert, Orit Sivan
The competition between sulfate reducing bacteria and methanogens over common substrates has been proposed as a critical control for methane production. In this study, we examined the co-existence of methanogenesis and sulfate reduction with shared substrates over a large range of sulfate concentrations and rates of sulfate reduction in estuarine systems, where these processes are the key terminal sink for organic carbon. Incubation experiments were carried out with sediment samples from the sulfate-methane transition zone of the Yarqon (Israel) estuary with different substrates and inhibitors along a sulfate concentrations gradient from 1 to 10 mM...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28529007/risk-factors-for-depression-differential-across-age
#16
Roxanne Schaakxs, Hannie C Comijs, Roos C van der Mast, Robert A Schoevers, Aartjan T F Beekman, Brenda W J H Penninx
INTRODUCTION: The occurrence of well-established risk factors for depression differs across the lifespan. Risk factors may be more strongly associated with depression at ages when occurrence, and therefore expectance, is relatively low ("on-time off-time" hypothesis). This large-scale study examined absolute and relative risks of established risk factors for depression across the lifespan. METHODS: Participants were 2,215 currently or never depressed adults aged 18 to 93 years from two cohort studies: NESDA and NESDO...
April 7, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28475278/anticoagulation-bridge-therapy-in-patients-with-atrial-fibrillation-recent-updates-providing-a-rebalance-of-risk-and-benefit
#17
Candice L Garwood, Bianca Korkis, Domenico Grande, Claudia Hanni, Amy Morin, Lynette R Moser
In 2011 we reviewed clinical updates and controversies surrounding anticoagulation bridge therapy in patients with atrial fibrillation (AF). Since then, options for oral anticoagulation have expanded with the addition of four direct oral anticoagulant (DOAC) agents available in the United States. Nonetheless, vitamin K antagonist (VKA) therapy continues to be the treatment of choice for patients who are poor candidates for a DOAC and for whom bridge therapy remains a therapeutic dilemma. This literature review identifies evidence and guideline and consensus statements from the last 5 years to provide updated recommendations and insight into bridge therapy for patients using a VKA for AF...
June 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28469813/evaluation-of-ex-vivo-effectiveness-of-commercial-desensitizing-dentifrices
#18
Hanny Mockdeci, Hudson Polonini, Isadora Martins, Ana-Paula Granato, Nádia Raposo, Maria-das Graças Chaves
BACKGROUND: Dentin hypersensitivity is a short, severe pain with fast onset. Therapy aims to either prevent or decrease neural transmission or physically occlude the dentinal tubules. This study aimed to evaluate the effectiveness of commercial desensitizing dentifrice by means of an ex vivo method. MATERIAL AND METHODS: Samples (n=8 lower human premolars for each group) were randomly allocated into: G1- brushing with Colgate®Sensitive Pro-Relief; G2- brushing with Sensodyne®Rapid Relief; G3- brushing with Sensodyne®Repair & Protect; and G4- brushing with Colgate®Maximum Cavity Protection...
April 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28462821/aging-of-bone-marrow-and-umbilical-cord-derived-mesenchymal-stromal-cells-during-expansion
#19
Samantha F H de Witte, Eleonora E Lambert, Ana Merino, Tanja Strini, Hannie J C W Douben, Lisa O'Flynn, Steve J Elliman, Annelies J E M M de Klein, Philip N Newsome, Carla C Baan, Martin J Hoogduijn
BACKGROUND AIMS: Mesenchymal stromal cells (MSCs) are used as experimental immunotherapy. Extensive culture expansion is necessary to obtain clinically relevant cell numbers, although the impact on MSCs stability and function is unclear. This study investigated the effects of long-term in vitro expansion on the stability and function of MSCs. METHODS: Human bone marrow-derived (bmMSCs) and umbilical cord-derived (ucMSCs) MSCs were in vitro expanded. During expansion, their proliferative capacity was examined...
July 2017: Cytotherapy
https://www.readbyqxmd.com/read/28453475/modifiable-risk-factors-for-prevention-of%C3%A2-dementia-in-midlife-late-life-and-the-oldest-old-validation-of-the-libra-index
#20
Stephanie J B Vos, Martin P J van Boxtel, Olga J G Schiepers, Kay Deckers, Marjolein de Vugt, Isabelle Carrière, Jean-François Dartigues, Karine Peres, Sylvaine Artero, Karen Ritchie, Lucia Galluzzo, Emanuele Scafato, Giovanni B Frisoni, Martijn Huisman, Hannie C Comijs, Simona F Sacuiu, Ingmar Skoog, Kate Irving, Catherine A O'Donnell, Frans R J Verhey, Pieter Jelle Visser, Sebastian Köhler
BACKGROUND: Recently, the LIfestyle for BRAin health (LIBRA) index was developed to assess an individual's prevention potential for dementia. OBJECTIVE: We investigated the predictive validity of the LIBRA index for incident dementia in midlife, late life, and the oldest-old. METHODS: 9,387 non-demented individuals were recruited from the European population-based DESCRIPA study. An individual's LIBRA index was calculated solely based on modifiable risk factors: depression, diabetes, physical activity, hypertension, obesity, smoking, hypercholesterolemia, coronary heart disease, and mild/moderate alcohol use...
2017: Journal of Alzheimer's Disease: JAD
keyword
keyword
118829
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"