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https://www.readbyqxmd.com/read/28107153/human-trafficking-mental-illness-and-addiction-avoiding-diagnostic-overshadowing
#1
Hanni Stoklosa, Marti MacGibbon, Joseph Stoklosa
This article reviews an emergency department-based clinical vignette of a trafficked patient with co-occurring pregnancy-related, mental health, and substance use disorder issues. The authors, including a survivor of human trafficking, draw on their backgrounds in addiction care, human trafficking, emergency medicine, and psychiatry to review the literature on relevant general health and mental health consequences of trafficking and propose an approach to the clinical complexities this case presents. In their discussion, the authors explicate the deleterious role of implicit bias and diagnostic overshadowing in trafficked patients with co-occurring addiction and mental illness...
January 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28099851/a-molecular-and-cellular-context-dependent-role-for-ir76b-in-detection-of-amino-acid-taste
#2
Anindya Ganguly, Lisa Pang, Vi-Khoi Duong, Angelina Lee, Hanni Schoniger, Erika Varady, Anupama Dahanukar
Amino acid taste is expected to be a universal property among animals. Although sweet, bitter, salt, and water tastes have been well characterized in insects, the mechanisms underlying amino acid taste remain elusive. From a Drosophila RNAi screen, we identify an ionotropic receptor, Ir76b, as necessary for yeast preference. Using calcium imaging, we identify Ir76b(+) amino acid taste neurons in legs, overlapping partially with sweet neurons but not those that sense other tastants. Ir76b mutants have reduced responses to amino acids, which are rescued by transgenic expression of Ir76b and a mosquito ortholog AgIr76b...
January 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/28089734/broadening-the-phenotype-of-dfnb28-mutations-in-triobp-are-associated-with-moderate-stable-hereditary-hearing-impairment
#3
Mieke Wesdorp, Jiddeke M van de Kamp, Erik F Hensen, Margit Schraders, Jaap Oostrik, Helger G Yntema, Ilse Feenstra, Ronald J C Admiraal, Henricus P M Kunst, Mustafa Tekin, Moien Kanaan, Hannie Kremer, Ronald J E Pennings
DFNB28 is characterized by prelingual, severe to profound sensorineural hearing impairment (HI). It is associated with mutations in exon 6 and 7 of TRIOBP and has not been reported in the European population. Here, we describe two isolated cases of Dutch origin with congenital, moderate HI and compound heterozygous mutations in TRIOBP. Three of the mutations are novel, one nonsense mutation (c.5014G>T (p.Gly1672*)) and two frameshift mutations (c.2653del (p.Arg885Alafs*120) and c.3460_3461del (p.Leu1154Alafs*29))...
January 12, 2017: Hearing Research
https://www.readbyqxmd.com/read/28067622/a-homozygous-fitm2-mutation-causes-a-deafness-dystonia-syndrome-with-motor-regression-and-signs-of-ichthyosis-and-sensory-neuropathy
#4
Celia Zazo Seco, Anna Castells-Nobau, Seol-Hee Joo, Margit Schraders, Jia Nee Foo, Monique van der Voet, S Sendhil Velan, Bonnie Nijhof, Jaap Oostrik, Erik de Vrieze, Radoslaw Katana, Atika Mansoor, Martijn Huynen, Radek Szklarczyk, Martin Oti, Lisbeth Tranebjærg, Erwin van Wijk, Jolanda M Scheffer-de Gooyert, Saadat Siddique, Jonathan Baets, Peter de Jonghe, Syed Ali Raza Kazmi, Suresh Anand Sadananthan, Bart P van de Warrenburg, Chiea Chuen Khor, Martin C Göpfert, Raheel Qamar, Annette Schenck, Hannie Kremer, Saima Siddiqi
A consanguineous family from Pakistan was ascertained with a novel deafness-dystonia syndrome with motor regression, ichthyosis-like features and signs of sensory neuropathy. By applying a combined strategy of linkage analysis and whole-exome sequencing in the presented family, a homozygous nonsense mutation, c.4G>T (p.Glu2*), in FITM2 was identified. FITM2 and its paralog FITM1 constitute an evolutionary conserved protein family involved in partitioning of triglycerides into cellular lipid droplets. Despite the role of FITM2 in neutral lipid storage and metabolism, no indications for lipodystrophy were observed in the affected individuals...
December 15, 2016: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28063852/gait-speed-and-processing-speed-as-clinical-markers-for-geriatric-health-outcomes
#5
Joost B Sanders, Marijke A Bremmer, Hannie C Comijs, Peter M van de Ven, Dorly J H Deeg, Aartjan T F Beekman
OBJECTIVE: This study investigates the independent and combined potential of slowed gait speed and slowed processing speed as predictors of adverse health outcomes. The role of depressive symptoms in these associations is also investigated. METHODS: In the prospective cohort study, using the Longitudinal Aging Study Amsterdam database, three study samples for each outcome variable were defined: persistent cognitive decline (PCD; N = 1,271, 13 years of follow-up), falls (N = 1,282, 6 years of follow-up), and mortality (N = 1,559, age 74...
December 6, 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28018628/amy2b-copy-number-variation-reveals-starch-diet-adaptations-in-ancient-european-dogs
#6
Morgane Ollivier, Anne Tresset, Fabiola Bastian, Laetitia Lagoutte, Erik Axelsson, Maja-Louise Arendt, Adrian Bălăşescu, Marjan Marshour, Mikhail V Sablin, Laure Salanova, Jean-Denis Vigne, Christophe Hitte, Catherine Hänni
Extant dog and wolf DNA indicates that dog domestication was accompanied by the selection of a series of duplications on the Amy2B gene coding for pancreatic amylase. In this study, we used a palaeogenetic approach to investigate the timing and expansion of the Amy2B gene in the ancient dog populations of Western and Eastern Europe and Southwest Asia. Quantitative polymerase chain reaction was used to estimate the copy numbers of this gene for 13 ancient dog samples, dated to between 15 000 and 4000 years before present (cal...
November 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/28004389/withdrawn-community-based-population-level-interventions-for-promoting-child-oral-health
#7
REVIEW
Andrea M de Silva, Shalika Hegde, Bridget Akudo Nwagbara, Hanny Calache, Mark G Gussy, Mona Nasser, Hannah R Morrice, Elisha Riggs, Pamela M Leong, Lisa K Meyenn, Reza Yousefi-Nooraie
BACKGROUND: Dental caries and gingival and periodontal disease are commonly occurring, preventable chronic conditions. Even though much is known about how to treat oral disease, currently we do not know which community-based population-level interventions are most effective and equitable in preventing poor oral health. OBJECTIVES: Primary • To determine the effectiveness of community-based population-level oral health promotion interventions in preventing dental caries and gingival and periodontal disease among children from birth to 18 years of age...
22, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28000701/the-diagnostic-yield-of-whole-exome-sequencing-targeting-a-gene-panel-for-hearing-impairment-in-the-netherlands
#8
Celia Zazo Seco, Mieke Wesdorp, Ilse Feenstra, Rolph Pfundt, Jayne Y Hehir-Kwa, Stefan H Lelieveld, Steven Castelein, Christian Gilissen, Ilse J de Wijs, Ronald Jc Admiraal, Ronald Je Pennings, Henricus Pm Kunst, Jiddeke M van de Kamp, Saskia Tamminga, Arjan C Houweling, Astrid S Plomp, Saskia M Maas, Pia Am de Koning Gans, Sarina G Kant, Christa M de Geus, Suzanna Gm Frints, Els K Vanhoutte, Marieke F van Dooren, Marie-José H van den Boogaard, Hans Scheffer, Marcel Nelen, Hannie Kremer, Lies Hoefsloot, Margit Schraders, Helger G Yntema
Hearing impairment (HI) is genetically heterogeneous which hampers genetic counseling and molecular diagnosis. Testing of several single HI-related genes is laborious and expensive. In this study, we evaluate the diagnostic utility of whole-exome sequencing (WES) targeting a panel of HI-related genes. Two hundred index patients, mostly of Dutch origin, with presumed hereditary HI underwent WES followed by targeted analysis of an HI gene panel of 120 genes. We found causative variants underlying the HI in 67 of 200 patients (33...
December 21, 2016: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/27925658/pro-b-cells-propagated-in-stromal-cell-free-cultures-reconstitute-functional-b-cell-compartments-in-immunodeficient-mice
#9
Lilly von Muenchow, Panagiotis Tsapogas, Llucia Albertí-Servera, Giuseppina Capoferri, Marianne Doelz, Hannie Rolink, Nabil Bosco, Rhodri Ceredig, Antonius G Rolink
Up to now long-term in vitro growth of pro-B cells was thought to require stromal cells. However, here we show that fetal liver (FL) and bone marrow (BM) derived pro-B cells can be propagated long-term in stromal cell-free cultures supplemented with IL-7, stem cell factor and FLT3 ligand. Within a week, most cells expressed surface CD19, CD79A, λ5, and VpreB antigens and had rearranged immunoglobulin D-J heavy chain genes. Both FL and BM pro-B cells reconstituted the B-cell compartments of immuno-incompetent Rag2-deficient mice, with FL pro-B cells generating follicular, marginal zone (MZB) and B1a B cells, and BM pro-B cells giving rise mainly to MZB cells...
December 7, 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27900664/improvement-production-of-hyaluronic-acid-by-streptococcus-zooepidemicus-in-sugarcane-molasses
#10
Nicole Caldas Pan, Hanny Cristina Braga Pereira, Maria de Lourdes Corradi da Silva, Ana Flora Dalberto Vasconcelos, Maria Antonia Pedrine Colabone Celligoi
Microbial hyaluronic acid (HA) production has been preferred rather than extraction from animal tissue for medical and cosmetic applications. In this context, to obtain an economically competitive HA production by Streptococcus zooepidemicus, culture conditions were studied to improve the polymer production in sugarcane molasses. The highest HA production by S. zooepidemicus ATCC 39920 achieved was 2.825 g. L(-1) in a 4.5 L bioreactor with controlled pH (8.0) and medium containing molasses (85.35 g.L(-1) total sugar) pretreated with activated charcoal and yeast extract (50 g...
November 30, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27871322/causes-of-maternal-and-child-mortality-among-cambodian-sex-workers-and-their-children-a-cross-sectional-study
#11
Brian Willis, Saki Onda, Hanni Marie Stoklosa
BACKGROUND: To reach global and national goals for maternal and child mortality, countries must identify vulnerable populations, which includes sex workers and their children. The objective of this study was to identify and describe maternal deaths of female sex workers in Cambodia and causes of death among their children. METHODS: A convenience sample of female sex workers were recruited by local NGOs that provide support to sex workers. We modified the maternal mortality section of the 2010 Cambodia Demographic and Health Survey and collected reports of all deaths of female sex workers...
November 21, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27868158/growth-and-prevalence-of-feeding-difficulties-in-children-with-robin-sequence-a-retrospective-cohort-study
#12
Emma C Paes, Iris A C de Vries, Wouter M Penris, Karlijn H Hanny, Selma W Lavrijsen, Elselien K van Leerdam, Maaike M Rademaker, Esther S Veldhoen, Rene M J C Eijkemans, Moshe Kon, Corstiaan C Breugem
OBJECTIVES: In addition to breathing problems, patients with Robin sequence (RS) often encounter feeding difficulties (FD). Data regarding the occurrence of FD and possible influencing factors are scarce. The study aim was to elucidate these factors to improve treatment strategies. MATERIAL AND METHODS: A retrospective comparative cohort study was conducted, consisting of 69 infants diagnosed with both RS and a cleft palate and 64 isolated cleft palate only (iCPO) infants...
November 21, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27833456/the-impact-of-caregiver-treatment-satisfaction-upon-child-and-parent-outcomes
#13
Mary Acri, Lindsay A Bornheimer, Lauren Jessell, Hanni B Flaherty, Mary M McKay
BACKGROUND: Parental perceptions about treatment influence their child's engagement in and ongoing utilization of mental health services, but less is known about the association between caregiver expectancies and family outcomes. The literature is particularly lacking with families of color, who are at high risk for the onset and perpetuation of disruptive behaviors. METHODS: The purpose of this study was to examine caregiver treatment satisfaction amongst 320 youth of color aged 7 to 11 and their families who were assigned to either a Multiple Family Group intervention or services as usual condition...
November 2016: Child and Adolescent Mental Health
https://www.readbyqxmd.com/read/27827534/correlates-of-sleep-disturbances-in-depressed-older-persons-the-netherlands-study-of-depression-in-older-persons-nesdo
#14
Rian Johanna Gerdina Peters van Neijenhof, Erik van Duijn, Hannie C Comijs, Julia F van den Berg, Margot W M de Waal, Richard C Oude Voshaar, Roos C van der Mast
OBJECTIVES: Sleep disturbances are common among depressed older persons. To gain insight into sleep disturbances in late-life depression, their occurrence and correlates were assessed. METHODS: Baseline data of 294 depressed older persons of the Netherlands Study of Depression in Older persons study were used. A diagnosis of current depression according to the diagnostic and statistical manual of mental disorders-IV (DSM-IV) was assessed with the Composite International Diagnostic Interview...
November 9, 2016: Aging & Mental Health
https://www.readbyqxmd.com/read/27802265/antisense-oligonucleotide-based-splice-correction-for-ush2a-associated-retinal-degeneration-caused-by-a-frequent-deep-intronic-mutation
#15
Radulfus Wn Slijkerman, Christel Vaché, Margo Dona, Gema García-García, Mireille Claustres, Lisette Hetterschijt, Theo A Peters, Bas P Hartel, Ronald Je Pennings, José M Millan, Elena Aller, Alejandro Garanto, Rob Wj Collin, Hannie Kremer, Anne-Françoise Roux, Erwin Van Wijk
Usher syndrome (USH) is the most common cause of combined deaf-blindness in man. The hearing loss can be partly compensated by providing patients with hearing aids or cochlear implants, but the loss of vision is currently untreatable. In general, mutations in the USH2A gene are the most frequent cause of USH explaining up to 50% of all patients worldwide. The first deep-intronic mutation in the USH2A gene (c.7595-2144A>G) was reported in 2012, leading to the insertion of a pseudoexon (PE40) into the mature USH2A transcript...
November 1, 2016: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/27800086/snakebite-in-bedroom-kills-a-physician-in-cameroon-a-case-report
#16
Armand Nkwescheu, Leopold Cyriaque Donfack Mbasso, Franky Baonga Ba Pouth, Anastase Dzudie, Serge Clotaire Billong, Hermann Ngouakam, Joseph Le Doux Diffo, Hanny Eyongorock, Wilfred Mbacham
The World Health Organization (WHO) classifies snake bites as neglected public health problem affecting mostly tropical and subtropical countries. In Africa there are an estimated 1 million snake bites annually with about half needing a specific treatment. Women, children and farmers in poor rural communities in developing countries are the most affected. Case management of snake bites are not adequate in many health facilities in developing countries where personnel are not always abreast with the new developments in snake bite management and in addition, quite often the anti-venom serum is lacking...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27771245/early-and-late-onset-depression-in-late-life-a-prospective-study-on-clinical-and-structural-brain-characteristics-and-response-to-electroconvulsive-therapy
#17
Annemiek Dols, Filip Bouckaert, Pascal Sienaert, Didi Rhebergen, Kristof Vansteelandt, Mara Ten Kate, Francois-Laurent de Winter, Hannie C Comijs, Louise Emsell, Mardien L Oudega, Eric van Exel, Sigfried Schouws, Jasmien Obbels, Mike Wattjes, Frederik Barkhof, Piet Eikelenboom, Mathieu Vandenbulcke, Max L Stek
OBJECTIVE: The clinical profile of late-life depression (LLD) is frequently associated with cognitive impairment, aging-related brain changes, and somatic comorbidity. This two-site naturalistic longitudinal study aimed to explore differences in clinical and brain characteristics and response to electroconvulsive therapy (ECT) in early- (EOD) versus late-onset (LOD) late-life depression (respectively onset <55 and ≥55 years). METHODS: Between January 2011 and December 2013, 110 patients aged 55 years and older with ECT-treated unipolar depression were included in The Mood Disorders in Elderly treated with ECT study...
September 22, 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27764950/experiences-of-vision-impairment-in-papua-new-guinea-implications-for-blindness-prevention-programs
#18
Anthea Burnett, Aryati Yashadhana, Maria Cabrera Aguas, Yvonne Hanni, Mitasha Yu
INTRODUCTION: A person's capability to access services and achieve good eye health is influenced by their behaviours, perceptions, beliefs and experiences. As evidence from Papua New Guinea (PNG) about people's lived experience with vision impairment is limited, the purpose of the present study was to better understand the beliefs, perceptions and emotional responses to vision impairment in PNG. METHODS: A qualitative study, using both purposive and convenience sampling, was undertaken to explore common beliefs and perceptions about vision impairment, as well as the emotional responses to vision impairment...
October 2016: Rural and Remote Health
https://www.readbyqxmd.com/read/27740642/scarring-of-soft-tissues-following-apical-surgery-visual-assessment-of-outcomes-one-year-after-intervention-using-the-bern-and-manchester-scores
#19
Thomas von Arx, Simone Fm Janner, Stefan Hänni, Michael M Bornstein
The successful outcome of apical surgery is usually defined by absence of clinical signs and symptoms and resolution of previous periapical radiolucencies. However, little attention is given to soft tissue scarring. The present study evaluated the severity of gingival and mucosal scarring 1 year following apical surgery of 52 teeth. Clinical pictures taken at the 1-year examination were rated by three observers using specific scarring scores. The overall repeatability of the two scores was high (85.3%), whereas the overall reproducibility was relatively low (44...
November 2016: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/27730226/high-internal-phase-emulsions-stabilized-solely-by-whey-protein-isolate-low-methoxyl-pectin-complexes-effect-of-ph-and-polymer-concentration
#20
Wahyu Wijaya, Paul Van der Meeren, Christofora Hanny Wijaya, Ashok R Patel
In recent years, there has been significant progress in edible emulsion technology especially with respect to creating and stabilizing surfactant-free emulsion systems for food applications. In this paper, we demonstrate the fabrication of high internal phase emulsions (HIPE) (φoil = 0.82) stabilized using colloidal complexes of non-gelling biopolymers (at concentrations as low as 0.3 wt%). The colloidal complexes were pre-formed by combining whey protein isolate (WPI) and low-methoxyl pectin (LMP) at three different pH values (i...
October 12, 2016: Food & Function
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