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Coagulase negative staph bacteremia

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https://www.readbyqxmd.com/read/27820968/safety-and-efficacy-of-daptomycin-in-outpatient-parenteral-antimicrobial-therapy-a-prospective-and-multicenter-cohort-study-daptodom-trial
#1
Carlos Cervera, Pedro Sanroma, Víctor González-Ramallo, Cristina García de la María, Gemma Sanclemente, Nieves Sopena, Marcos Pajarón, Antonio Segado, Manuel Mirón, Francisco Antón, Andima Basterretxea, Ana Cuende, José M Miró
BACKGROUND: Daptomycin is an optimal choice for outpatient parenteral antibiotic therapy (OPAT) because of its safety, once-daily administration and its activity against Gram-positive bacteria. Although daptomycin is increasingly being used in OPAT, limited information about its safety in this scenario is available. METHODS: We performed a prospective multicentre pilot study to evaluate the safety of daptomycin in outpatients with proved or suspected Gram-positive infections (DAPTODOM)...
November 8, 2016: Infectious Diseases
https://www.readbyqxmd.com/read/27777118/the-occurrence-of-infective-endocarditis-with-staphylococcus-lugdunensis-bacteremia-a-retrospective-cohort-study-and-systematic-review
#2
Lemuel R Non, Carlos A Q Santos
BACKGROUND: Staphylococcus lugdunensis is a coagulase-negative staphylococcus with similar virulence characteristics as S. aureus. Whether S. lugdunensis causes infective endocarditis (IE) in a similar proportion of cases as S. aureus (reported to be 12.6% in a definitive multicenter prospective study) is unclear. METHODS: We conducted a retrospective cohort study of adult patients with at least one blood culture positive for S. lugdunensis at our institution from January 2006 to December 2014...
October 21, 2016: Journal of Infection
https://www.readbyqxmd.com/read/27730778/antibiotic-lock-therapy-in-the-era-of-gram-negative-resistance
#3
Rajeev Soman, Neha Gupta, Mitesh Suthar, Jatin Kothari, Alan Almeida, Anjali Shetty, Camilla Rodrigues
BACKGROUND: Central-line-associated blood-stream infection (CLABSI) is a highly consequential nosocomial infection. The most effective management includes the removal of the infected catheter. Retention of the catheter and antibiotic lock therapy (ALT) along with systemic antibiotics may be attempted only if there are unusual extenuating circumstances. CLABSIs due to Gram-negative bacteria (GNB) is more common in our setting and the organisms are often highly resistant. Hence, there is a need to explore the use of novel antimicrobials for catheter lock solutions along with antibiofilm agents...
February 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27645121/risk-factors-for-persistent-bacteremia-in-infants-with-catheter-related-bloodstream-infection-due-to-coagulase-negative-staphylococcus-in-the-neonatal-intensive-care-unit
#4
Munehiro Furuichi, Isao Miyairi
BACKGROUND: Coagulase-negative Staphylococcus (CoNS) is the predominant cause of catheter-related bloodstream infections (CRBSI). Infants in neonatal intensive care units (NICU) often suffer from CoNS CRBSI, which are often refractory to treatment. OBJECTIVES: We sought to evaluate risk factors for developing persistent bacteremia due to CoNS CRBSI in infants, in order to identify those who require early aggressive management. METHODS: We conducted a retrospective case-control study of infants in the NICU who developed CRBSI due to CoNS...
September 16, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27571200/rapid-diagnosis-of-staphylococcal-catheter-related-bacteraemia-in-direct-blood-samples-by-real-time-pcr
#5
Yuliya Zboromyrska, Cristina De la Calle, Marcelo Soto, Laura Sampietro-Colom, Alex Soriano, Míriam José Alvarez-Martínez, Manel Almela, Francesc Marco, Ruth Arjona, Nazaret Cobos-Trigueros, Laura Morata, José Mensa, José Antonio Martínez, Aurea Mira, Jordi Vila
Catheter-related bacteremia (CRB) is an important cause of morbidity and mortality among hospitalized patients, being staphylococci the main etiologic agents. The objective of this study was to assess the use of a PCR-based assay for detection of staphylococci directly from blood obtained through the catheter to diagnose CRB caused by these microorganisms and to perform a cost-effectiveness analysis. A total of 92 patients with suspected CRB were included in the study. Samples were obtained through the catheter...
2016: PloS One
https://www.readbyqxmd.com/read/27443564/organism-specific-bacteremia-by-hemodialysis-access
#6
Jingjing Zhang, Renee A Burr, Heena S Sheth, Beth Piraino
BACKGROUND: Data on hemodialysis (HD)-related organism specific bacteremia rates by type of access over an extended period are scant in the literature. Using a registry data base we examined all positive blood cultures by organisms for each type of HD access over 14 years. METHODS: The IRB-approved registry data collection of prevalent patients at our HD unit from 1/1/1999 through 12/31/2012 was analyzed. All positive blood cultures were recorded and expressed as episodes/1,000 days by access type: arteriovenous fistula (AVF), arteriovenous graft (AVG), and central venous catheter (CVC)...
September 2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27268592/bacteremia-due-to-eskape-pathogens-an-emerging-problem-in-cancer-patients
#7
Hadir A El-Mahallawy, Safaa Shawky Hassan, Mohamed El-Wakil, Manar M Moneer
BACKGROUND AND AIM: In recent years, a few of the antibiotic-resistant bacteria, known as ESKAPE pathogens, have been found responsible for serious infections. We investigated the risk factors, and impact of ESKAPE pathogens on course of blood stream infections (BSIs) in cancer patients in comparison to coagulase negative Staphylococci (CoNS). PATIENTS AND METHODS: The data of patients with ESKAPE positive blood cultures at National Cancer Institute, Cairo University were analyzed...
September 2016: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/27132208/evaluating-the-management-of-493-patients-presenting-with-bacteremia-in-23-northern-french-hospitals
#8
S Alfandari, P Cabaret, S Nguyen, D Descamps, A Vachée, C Cattoen, N Van Grunderbeeck
OBJECTIVES: We aimed to update the epidemiology of bacteremia and evaluate their management and short-term outcome. METHODS: We conducted a prospective multicenter survey from October to November 2011. Consecutive patients with at least one positive blood culture (BC) were included in the study. We evaluated the type and adequacy of empirical and documented antibiotic therapy, time to active antibiotic therapy, compliance with guidelines, and 10-day outcome. RESULTS: A total of 23 public and private hospitals and 633 patients (493 true pathogens and 140 contaminants) were included in the study...
June 2016: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/27110844/predicting-clinical-outcomes-in-patients-with-negative-peripheral-and-positive-central-blood-culture-with-coagulase-negative-staphylococcus-species
#9
Lokesh Shahani, Rabih O Darouiche
OBJECTIVES: Clinical outcomes in patients with negative peripheral and positive central blood culture with coagulase negative staphylococci (CoNS) based on different treatment approach such as intravenous antibiotics, removal of CVC, combined approach or just observation are not known. METHODS: We conducted a retrospective review of patients with negative peripheral and paired positive central blood culture with CoNS admitted at our affiliated hospital between 2008 to 2013...
April 28, 2016: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/27092283/pbp-2-negative-methicillin-resistant-staphylococcus-schleiferi-bacteremia-from-a-prostate-abscess-an-unusual-occurrence
#10
Chandni Merchant, Daphne-Dominique Villanueva, Ishan Lalani, Margaret Eng, Yong Kang
Staphylococcus schleiferi subsp. schleiferi is a coagulase-negative Staphylococcus which has been described as a pathogen responsible for various nosocomial infections including bacteremia, brain abscess, and infection of intravenous pacemakers. Recently, such bacteria have been described to be found typically on skin and mucosal surfaces. It is also believed to be a part of the preaxillary human flora and more frequently found in men. It is very similar in its pathogenicity with Staphylococcus aureus group and expresses a fibronectin binding protein...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/26951119/study-on-daptomycin-use-and-implementation-of-an-antimicrobial-stewardship-program
#11
Camille Castel, Arnaud de La Blanchardière, Jocelyn Michon, Vincent Cattoir, Guillaume Saint-Lorant
BACKGROUND: Treatment of Gram-positive pathogens remains a major health issue due to the presence of methicillin-resistant Staphylococcus aureus (MRSA) and Vancomycin-Resistant Enterococcus spp. Daptomycin offers an alternative after therapeutic failure using glycopeptides. Yet its use requires strict control given its financial impact and environmental risks. Since 2014, the use of daptomycin within our hospital has intensified, occasionally outside the scope of its approved indications...
April 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/26950194/bloodstream-infections-in-hiv-infected-patients
#12
Lucia Taramasso, Paola Tatarelli, Antonio Di Biagio
In the combined antiretroviral therapy era, HIV-infected patients remain a vulnerable population for the onset of bloodstream infections (BSI). Worldwide, nontyphoid salmonellae, Streptococcus pneumoniae, Escherichia coli, Staphylococcus aureus and coagulase negative staphylococci are the most important pathogens. Intravenous catheter associated infection, skin-soft tissue infection and endocarditis are associated with Gram-positive bacteremia. Among the Gram-negative, nontyphoidal Salmonella have been previously correlated to sepsis...
April 2, 2016: Virulence
https://www.readbyqxmd.com/read/26905550/frequency-of-blood-culture-isolates-and-their-antibiogram-in-a-teaching-hospital
#13
Subha Shrestha, Ritu Amatya, Raj Kumari Shrestha, Rajiv Shrestha
INTRODUCTION: Bloodstream infections are associated with significant patient morbidity and mortality. Antimicrobial susceptibility patterns should guide the choice of empiric antimicrobial regimens for patients with bacteremia. METHODS: Blood sample received from the patient attending Nepal Medical College and Teaching Hospital from March, 2012 - August, 2012 were subjected to culture. Isolate identification and antimicrobial susceptibility testing was done by standard microbiological method...
January 2014: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/26898664/frequency-clinical-manifestations-and-outcomes-of-staphylococcus-lugdunensis-bacteremia-in-children
#14
Masanori Sato, Noriko Kubota, Ayaka Horiuchi, Masashi Kasai, Kisei Minami, Hikoro Matsui
BACKGROUND: Staphylococcus lugdunensis (S. lugdunensis) is known as a common cause of clinically significant infections in adults although the clinical importance of S. lugdunensis isolates from pediatric samples is less known. The aim of this study is to assess the incidence, characteristics, and outcomes of S. lugdunensis bacteremia (SLB) in children. METHODS: From January 2009 to March 2014, all blood culture isolates were retrospectively screened for S. lugdunensis...
May 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/26766146/bloodstream-infections-in-hospitalized-children-epidemiology-and-antimicrobial-susceptibilities
#15
Beatriz Larru, Wu Gong, Neika Vendetti, Kaede V Sullivan, Russell Localio, Theoklis E Zaoutis, Jeffrey S Gerber
BACKGROUND: Bloodstream infection is a major cause of morbidity and mortality. Much of our understanding of the epidemiology and resistance patterns of bloodstream infections comes from studies of hospitalized adults. METHODS: We evaluated the epidemiology and antimicrobial resistance of bloodstream infections occurring during an 11-year period in a large, tertiary care children's hospital in the US. All positive blood cultures were identified retrospectively from clinical microbiology laboratory records...
May 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/26744589/staphylococcus-pettenkoferi-bacteremia-a-case-report-and-review-of-the-literature
#16
Abdulaziz Ahmed Hashi, Johannes Andries Delport, Sameer Elsayed, Michael Seth Silverman
Staphylococcus pettenkoferi is a relatively recently described coagulase-negative staphylococci species first described in 2002. Since then, nine additional cases of infection caused by this species have been reported in various countries around the world, including Germany, Belgium, France, South Korea, Italy, Brazil and Mexico. The present report describes a case of S pettenkoferi peripheral line-associated bacteremia. To our knowledge, the present report is the first description of human infection caused by S pettenkoferi in Canada...
November 2015: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/26656049/association-between-lumbar-disc-degeneration-and-propionibacterium-acnes-infection-clinical-research-and-preliminary-exploration-of-animal-experiment
#17
Bo Li, Zhe Dong, Yongchao Wu, Ji Zeng, Qixin Zheng, Baojun Xiao, Xianyi Cai, Zhiyong Xiao
STUDY DESIGN: Clinical research and animal experiment. OBJECTIVE: To investigate whether lumbar disc degeneration is associated with Propionibacterium acnes (P acnes) infection. SUMMARY OF BACKGROUND DATA: The hypothesis that herniated discs may be infected with P acnes by way of bacteremia is remarkable. This may bring a tremendous change in treatment of lumbar disc herniation (LDH). However, this hypothesis is still controversial. Since P acnes isolated may be related to contamination...
July 1, 2016: Spine
https://www.readbyqxmd.com/read/26639226/clinical-and-economic-impact-of-antimicrobial-stewardship-interventions-with-the-filmarray-blood-culture-identification-panel
#18
Joe Pardo, Kenneth P Klinker, Samuel J Borgert, Brittany M Butler, Patricia G Giglio, Kenneth H Rand
The purpose of this study was to evaluate the impact of the FilmArray Blood Culture Identification (BCID) Panel on the management of patients with blood cultures growing gram positive cocci and Candida. We retrospectively compared clinical and economic outcomes between patients during the BCID testing period and a matched historical control group before BCID testing was introduced. A total of 84 BCID patients were matched to 252 historical controls. BCID identification of coagulase negative staphylococci contaminants resulted in shorter post-culture length of stay (P < 0...
February 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/26610384/evaluation-of-effectiveness-and-safety-of-high-dose-daptomycin-results-from-patients-included-in-the-european-cubicin-%C3%A2-outcomes-registry-and-experience
#19
R Andrew Seaton, Francesco Menichetti, Georgios Dalekos, Andres Beiras-Fernandez, Francisco Nacinovich, Rashidkhan Pathan, Kamal Hamed
INTRODUCTION: Daptomycin, a rapid concentration-dependent bactericidal antibiotic, is approved at a dose of 4 mg/kg/day for the treatment of complicated skin and soft tissue infections (cSSTI) and at a dose of 6 mg/kg/day for the treatment of Staphylococcus aureus right-sided infective endocarditis (RIE) and bacteremia associated with cSSTI and RIE. Studies have reported the successful use of high-dose daptomycin (>6 mg/kg/day) in patients with difficult-to-treat infections. The present analysis evaluated the effectiveness and safety of high doses (>6 mg/kg/day) of daptomycin for the treatment of different Gram-positive infections...
December 2015: Advances in Therapy
https://www.readbyqxmd.com/read/26598385/effectiveness-of-practices-to-increase-timeliness-of-providing-targeted-therapy-for-inpatients-with-bloodstream-infections-a-laboratory-medicine-best-practices-systematic-review-and-meta-analysis
#20
REVIEW
Stephanie S Buehler, Bereneice Madison, Susan R Snyder, James H Derzon, Nancy E Cornish, Michael A Saubolle, Alice S Weissfeld, Melvin P Weinstein, Edward B Liebow, Donna M Wolk
BACKGROUND: Bloodstream infection (BSI) is a major cause of morbidity and mortality throughout the world. Rapid identification of bloodstream pathogens is a laboratory practice that supports strategies for rapid transition to direct targeted therapy by providing for timely and effective patient care. In fact, the more rapidly that appropriate antimicrobials are prescribed, the lower the mortality for patients with sepsis. Rapid identification methods may have multiple positive impacts on patient outcomes, including reductions in mortality, morbidity, hospital lengths of stay, and antibiotic use...
January 2016: Clinical Microbiology Reviews
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