Field M Watts, Tim Pouland, Richard A Bunce, K Darrell Berlin, Doris M Benbrook, Maryam Mashayekhi, Dipendra Bhandari, Donghua Zhou
Five series of chromans with urea and thiourea linkers connecting a chroman unit (ring A) and a 4-substituted benzene unit (ring B) have been prepared and evaluated relative to SHetA2 (NSC 721689) for activity against the human A2780 ovarian cancer cell line. The lead compound SHetA2 had a sulfur in place of the oxygen in ring A and a thiourea linker to ring B. The 2-Me-4-Me series (two sets of geminal dimethyl groups at C2 and at C4 on the ring A unit) permitted direct comparison with SHetA2. Ring B in this series was evaluated with specific functional groups at C4 on the ring, including NO2 , CO2 Et, CF3 , OCF3 , CN and SO2 NH2 ...
October 5, 2018: European Journal of Medicinal Chemistry