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https://www.readbyqxmd.com/read/29343890/first-two-bilateral-hand-transplantations-in-india-part-2-technical-details
#1
Mohit Sharma, Subramania Iyer, P Kishore, Jimmy Mathew, Raghuveer Reddy, Janarthanan Ramu, Sundeep Vijayaraghavan, Abhijeet Wakure, S M Mali Chetan, Visakh Varma, Ashish Chaudhari, Swapnil Dhake, Akshay Omkumar, Jerry Paul, Sunil Rajan, Ayyappan Nair, Druvan Shaji
Introduction: This article deals with two patients who underwent bilateral hand transplantation following amputation of both upper limbs at the distal third of the foream. Materials and Methods: The first patient had a history of loss of hands in a train accident , with possiblity of a run over element during the injury. The second patient lost his both hands in a mine blast. The preoperative work up included detailed clinical and psychological evaluation. The donor retrieval was similar in both the cases and the donors were housed in our own instittution...
May 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29343209/mild-blast-injury-produces-acute-changes-in-basal-intracellular-calcium-levels-and-activity-patterns-in-mouse-hippocampal-neurons
#2
Kyle R Hansen, Gloria J DeWalt, Ali I Mohammed, Hua-An Tseng, Moona E Abdulkerim, Seth Bensussen, Venkatesh Saligrama, Bobak Nazer, William D Eldred, Xue Han
Mild traumatic brain injury (mTBI) represents a serious public health concern. While much is understood about long term changes in cell signaling and anatomical pathologies associated with mTBI, little is known about acute changes in neuronal function. Using large scale Ca2+ imaging in vivo, we characterized the intracellular Ca2+ dynamics in thousands of individual hippocampal neurons using a repetitive mild blast injury model where blasts were directed onto the cranium of unanesthetized mice on two consecutive days...
January 17, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29331949/bibliometric-analysis-of-military-trauma-publications-2000-2016
#3
Mark L Vickers, C P Coorey, G J Milinovich, L Eriksson, M Assoum, M C Reade
INTRODUCTION: Bibliometric tools can be used to identify the authors, topics and research institutions that have made the greatest impact in a field of medicine. The aim of this research was to analyse military trauma publications over the last 16 years of armed conflict in order to highlight the most important lessons that have translated into civilian practice and military doctrine as well as identify emerging areas of importance. METHODS: A systematic search of research published between January 2000 and December 2016 was conducted using the Thompson Reuters Web of Science database...
January 13, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29326126/one-hundred-years-and-counting-of-blast-associated-traumatic-brain-injury
#4
EDITORIAL
Kevin Kinch, J L Fullerton, W Stewart
Blast-associated traumatic brain injury (TBI) has become one of the signature issues of modern warfare and is increasingly a concern in the civilian population due to a rise in terrorist attacks. Despite being a recognised feature of combat since the introduction of high explosives in conventional warfare over a century ago, only recently has there been interest in understanding the biology and pathology of blast TBI and the potential long-term consequences. Progress made has been slow and there remain remarkably few robust human neuropathology studies in this field...
January 10, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29309519/impact-of-blast-injury-on-hearing-in-a-screened-male-military-population
#5
Antony R Joseph, Jaime L Shaw, Mary C Clouser, Andrew J MacGregor, Michael R Galarneau
Exposure to hazardous intensity levels of combat noise, such as blast, may compromise a person's ability to detect and recognize sounds and communicate effectively. There is little previous examination of the onset of hearing health outcomes following exposure to blast in representative samples of deployed US military personnel. Data from the prospective Blast-Related Auditory Injury Database were analyzed. We included only those participants with qualified hearing tests within a period of 12 months prior to, and following, injury (n = 1,574)...
January 1, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29309023/a-randomized-controlled-trial-to-evaluate-approaches-to-auditory-rehabilitation-for-blast-exposed-veterans-with-normal-or-near-normal-hearing-who-report-hearing-problems-in-difficult-listening-situations
#6
Gabrielle H Saunders, Melissa T Frederick, Michelle L Arnold, ShienPei C Silverman, Theresa H Chisolm, Paula J Myers
BACKGROUND: Blast exposure is a major source of injury among Service members in the Iraq and Afghanistan conflicts. Many of these blast-exposed veterans report hearing-related problems such as difficulties understanding speech in noise and rapid speech, and following instructions and long conversations that are disproportionate to their measured peripheral hearing sensitivity. Evidence is mounting that these complaints result from damage to the central auditory processing system. PURPOSE: To evaluate the effectiveness of audiological rehabilitative interventions for blast-exposed veterans with normal or near-normal peripheral hearing and functional hearing difficulties...
January 2018: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29297271/commentary-on-tympanoplasty-following-blast-injury
#7
Zheng-Cai Lou
No abstract text is available yet for this article.
January 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29287039/effect-of-blast-injury-on-auditory-localization-in-military-service-members
#8
Lina R Kubli, Douglas Brungart, Jerry Northern
OBJECTIVES: Among the many advantages of binaural hearing are the abilities to localize sounds in space and to attend to one sound in the presence of many sounds. Binaural hearing provides benefits for all listeners, but it may be especially critical for military personnel who must maintain situational awareness in complex tactical environments with multiple speech and noise sources. There is concern that Military Service Members who have been exposed to one or more high-intensity blasts during their tour of duty may have difficulty with binaural and spatial ability due to degradation in auditory and cognitive processes...
December 27, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/29286974/a-combined-distal-tibial-turn-up-plasty-and-intercalary-calcaneal-osteocutaneous-fillet-flap-for-salvage-of-a-transtibial-amputation-a-case-report
#9
Sean M Wade, Colin Harrington, Mark Fleming, Benjamin K Potter
CASE: This case demonstrates the successful attempt at a combined distal tibial turn-up plasty and intercalary calcaneal osteocutaneous fillet flap to increase functional limb length in order to salvage a transtibial amputation following a high-energy blast injury. CONCLUSION: A transtibial amputation is preferred over more proximal levels of amputation because of the decreased energy expenditure that is required for ambulation. In cases where there is not enough viable tibia to allow for a transtibial level of amputation, combining a calcaneal osteocutaneous fillet flap with a distal tibial turn-up plasty can be utilized to optimize residual limb length for a transtibial amputation...
October 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29285980/xenon-protects-against-blast-induced-traumatic-brain-injury-in-an-i-in-vitro-i-model
#10
Rita Campos-Pires, Mariia Koziakova, Amina Yonis, Ashni Pau, Warren Macdonald, Katie Harris, Christopher Edge, Nicholas P Franks, Peter Mahoney, Robert Dickinson
The aim of this study was to evaluate the neuroprotective efficacy of the inert gas xenon as a treatment for blast-induced traumatic brain injury in an in vitro laboratory model. We developed a novel blast traumatic brain injury model using C57BL/6N mouse organotypic hippocampal brain-slice cultures exposed to a single shockwave, with the resulting injury quantified using propidium iodide fluorescence. A shock tube blast generator was used to simulate open field explosive blast shockwaves, modeled by the Friedlander waveform...
December 29, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29284552/retrospective-and-prospective-memory-among-oef-oif-ond-veterans-with-a-self-reported-history-of-blast-related-mtbi
#11
Kathleen F Pagulayan, Holly Rau, Renee Madathil, Madeleine Werhane, Steven P Millard, Eric C Petrie, Brett Parmenter, Sarah Peterson, Scott Sorg, Rebecca Hendrickson, Cindy Mayer, James S Meabon, Bertrand R Huber, Murray Raskind, David G Cook, Elaine R Peskind
OBJECTIVES: To evaluate prospective and retrospective memory abilities in Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Operation New Dawn (OND) Veterans with and without a self-reported history of blast-related mild traumatic brain injury (mTBI). METHODS: Sixty-one OEF/OIF/OND Veterans, including Veterans with a self-reported history of blast-related mTBI (mTBI group; n=42) and Veterans without a self-reported history of TBI (control group; n=19) completed the Memory for Intentions Test, a measure of prospective memory (PM), and two measures of retrospective memory (RM), the California Verbal Learning Test-II and the Brief Visuospatial Memory Test-Revised...
December 29, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29275611/-study-on-changes-of-calpain-and-myocardial-damage-in-rats-with-burn-blast-combined-injury
#12
F Xie, J K Chai, Q Hu, Y H Yu, H F Zhai, H Y Chou, S S Kang
Objective: To study myocardial damage and rules of calpain change in rats with burn-blast combined injury. Methods: One hundred and twenty-eight male SD rats were randomly divided into control group, burn group, blast group, burn-blast group, with 32 rats in each group. CONTROL GROUP: 37 degrees' warm water for 12 s; Burn group: 94 degrees' boiling water for 12 s; Blast group: 5 g cyclonite explode in 75 cm distance from left chest wall of rat; Burn-blast group: burn group and blast group combined modeling method...
December 12, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29248744/underbody-blast-effect-on-the-pelvis-and-lumbar-spine-a-computational-study
#13
Jianyin Lei, Feng Zhu, Binhui Jiang, Zhihua Wang
Explosion from an anti-tank landmine under a military vehicle, known as underbody blast (UBB), may cause severe injury or even death for the occupants inside the vehicle. Severity and patterns of lower extremity, pelvis and lumbar spine injuries subjected to UBB have been found highly related to loading conditions, i.e. the vertical acceleration pulse. A computational human model has been developed and successfully simulated the tibia fracture under UBB in the previous study. In the present study, it was further improved by building a detailed lumbar spine and pelvis model with high biofidelity...
December 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29241762/eltrombopag-for-advanced-myelodysplastic-syndromes-or-acute-myeloid-leukaemia-and-severe-thrombocytopenia-aspire-a-randomised-placebo-controlled-phase-2-trial
#14
Moshe Mittelman, Uwe Platzbecker, Boris Afanasyev, Sebastian Grosicki, Raymond S M Wong, Achilles Anagnostopoulos, Benjamin Brenner, Claudio Denzlinger, Giuseppe Rossi, Arnon Nagler, Regina Garcia-Delgado, Maria Socorro O Portella, Zewen Zhu, Dominik Selleslag
BACKGROUND: Thrombocytopenia is a life-threatening complication in patients with advanced myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML). In this study (ASPIRE), we aimed to assess eltrombopag, an oral thrombopoietin receptor agonist, for thrombocytopenia (grade 4) treatment in adult patients with advanced MDS or AML. METHODS: ASPIRE consisted of an open-label, double-blind phase for 8 weeks and a randomised, double-blind phase (parts 1 and 2, reported here) for 12 weeks, and an open-label extension (part 3)...
December 11, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/29239267/a-retrospective-study-of-predictors-of-return-to-duty-vs-medical-retirement-in-an-active-duty-military-population-with-blast-related-mild-traumatic-brain-injury
#15
Philip A Cook, Thomas M Johnson, Suzanne G Martin, Philip R Gerhman, Seema Bhatnagar, James C Gee
Traumatic Brain Injury (TBI), has been described as the "signature injury" of the Global War on Terror. Explosive blast TBI has become a leading cause of injury as a result of the widespread use of improvised explosive devices in Iraq and Afghanistan. We present a retrospective cross-sectional study of patients with blast-related mild TBI (N=303) seen at the Intrepid Spirit Concussion Recovery Center at Naval Medical Center Camp Lejeune. The objective was to predict outcomes of return to duty (RTD) vs. medical retirement via medical evaluation board (MEB), based on brain imaging, neuropsychological data and history of mTBI...
December 14, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29222564/primary-blast-brain-injury-mechanisms-current-knowledge-limitations-and-future-directions
#16
Elizabeth Fievisohn, Zachary Bailey, Allison Guettler, Pamela VandeVord
Mild blast traumatic brain injury (bTBI) accounts for the majority of brain injury in United States service members and other military personnel worldwide. The mechanisms of primary blast brain injury continue to be disputed with little evidence to support one or a combination of theories. The main hypotheses addressed in this review are blast wave transmission through the skull orifices, direct cranial transmission, skull flexure dynamics, thoracic surge, acceleration, and cavitation. Each possible mechanism is discussed using available literature with the goal of focusing research efforts to address limitations and challenges that exist in blast injury research...
December 9, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29203201/combat-related-acetabular-fractures-outcomes-of-open-versus-closed-injuries
#17
Richard L Purcell, Michael A Donohue, Sameer K Saxena, Wade T Gordon, Louis L Lewandowski
INTRODUCTION: Since the onset of the Global War on Terror close to 50,000 United States service members have been injured in combat, many of these injuries would have previously been fatal. Among these injuries, open acetabular fractures are at an increased number due to the high percentage of penetrating injuries such as high velocity gunshot wounds and blast injuries. These injuries lead to a greater degree of contamination, and more severe associated injuries. There is a significantly smaller proportion of the classic blunt trauma mechanism typically seen in civilian trauma...
December 1, 2017: Injury
https://www.readbyqxmd.com/read/29197302/the-effect-of-impact-duration-on-the-axial-fracture-tolerance-of-the-isolated-tibia-during-automotive-and-military-impacts
#18
Alberto A Martinez, Avery B Chakravarty, Cheryl E Quenneville
Axial impacts to the lower leg during debilitating events such as frontal automotive collisions and military underbody blasts can cause significant injuries to the tibia. Several studies have conducted axial impact tests to determine the injury limits of the lower leg, mostly focused on automotive intrusions, resulting in an established force criterion for injury assessments. Due to the viscoelastic properties of bone, it remains unclear whether results from automotive experiments can be applied to higher-rate military blasts...
November 10, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29192506/extensive-hand-thermal-and-blast-injury-from-electronic-cigarette-explosion-a-case-report
#19
Ellen S Satteson, Nicholas J Walker, Christopher J Tuohy, Joseph A Molnar
BACKGROUND: As the use of electronic cigarettes rises, more reports of injuries related to device explosion are surfacing. METHODS: Presented here is the case of a 35-year-old man sustaining extensive thermal and blast injuries to his hand when the device exploded while he was holding it. He required multiple surgeries involving groin flap coverage, tendon transfer, and nerve grafting to optimize his postinjury function. RESULTS: While much of his hand function has been restored, he has continued deficits in range of motion and sensation as a result of the incident...
November 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29191509/cavitation-nucleation-in-gelatin-experiment-and-mechanism
#20
Wonmo Kang, Adnan Ashfaq, Thomas O'Shaughnessy, Amit Bagchi
Dynamic cavitation in soft materials is becoming increasingly relevant due to emerging medical implications such as the potential of cavitation-induced brain injury or cavitation created by therapeutic medical devices. However, the current understanding of dynamic cavitation in soft materials is still very limited, mainly due to lack of robust experimental techniques. To experimentally characterize cavitation nucleation under dynamic loading, we utilize a recently developed experimental instrument, the integrated drop tower system...
December 2, 2017: Acta Biomaterialia
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