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https://www.readbyqxmd.com/read/29352431/analysis-and-comparison-of-the-8th-edition-american-joint-committee-on-cancer-ajcc-nodal-staging-system-in-cutaneous-and-oral-squamous-cell-cancer-of-the-head-and-neck
#1
Nikolaus Moeckelmann, Ardalan Ebrahimi, Richard Dirven, Jessica Liu, Tsu-Hui Hubert Low, Ruta Gupta, Bruce Ashford, Sydney Ch'ng, Carsten E Palme, Jonathan R Clark
BACKGROUND: The American Joint Committee on Cancer (AJCC) uses the same nodal staging system for cutaneous and mucosal squamous cell carcinoma of the head and neck in its 8th edition (AJCC 8) despite differences in the etiology, risk factors, and clinical behavior of the two diseases. This study aims to evaluate the performance of the AJCC 8 nodal staging system by direct comparison of cutaneous (cSCC) versus oral squamous cell carcinoma (oSCC) patients. METHODS: Patients with metastatic cSCC (N = 382) and oSCC (N = 325) were identified from a prospective database (years 1987-2016)...
January 19, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29340491/survival-in-a-cohort-of-patients-with-lung-cancer-the-role-of-age-and-gender-in-prognosis
#2
Juliana Pereira Franceschini, Sérgio Jamnik, Ilka Lopes Santoro
OBJECTIVE: To determine the demographic and clinical characteristics of patients with non-small cell lung cancer (NSCLC), as well as their disease course, by age group and gender. METHODS: This was a retrospective cohort study of patients diagnosed with NSCLC from 2000 to 2012 and followed until July 2015 in a tertiary referral hospital in the city of São Paulo, Brazil. Based on the 25th and 75th percentiles of the age distribution, patients were stratified into three age groups: < 55 years; ≥ 55 and < 72 years; and ≥ 72 years...
November 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29337622/isolation-of-avipoxvirus-from-tongue-of-canaries-serinus-canaria-show-severe-localized-proliferative-glossitis
#3
Salvatore Catania, Silvia Carnaccini, Marta Mainenti, Maria Luisa Moronato, Federica Gobbo, Terregino Calogero
Poxvirus was the causative agent of two unusual outbreaks of proliferative glossitis in canary ( Serinus canaria forma domestica) breeders in the Northern Italy. A total of 45, 7-9-mo-old canaries were submitted in fair postmortem conditions to the Istituto Zooprofilattico Sperimentale delle Venezie at the beginning of November 2005 for diagnostic investigation. Birds belonged to two unrelated and geographically distant aviaries in northern Italy, herein identified as Aviary A and Aviary B. The two breeder flocks had both attended the same bird exposition held at the beginning of October and started experiencing an onset of high mortality 3 wk after the show...
December 2017: Avian Diseases
https://www.readbyqxmd.com/read/29332704/cutaneous-squamous-cell-carcinoma-incidence-risk-factors-diagnosis-and-staging
#4
REVIEW
Syril Keena T Que, Fiona O Zwald, Chrysalyne D Schmults
Cutaneous squamous cell carcinoma (cSCC), a malignant proliferation of cutaneous epithelium, represents 20% to 50% of skin cancers. Although the majority of cSCCs are successfully eradicated by surgical excision, a subset of cSCC possesses features associated with a higher likelihood of recurrence, metastasis, and death. The proper identification of these aggressive cSCCs can guide additional work-up and management. In the first article in this continuing medical education series, we discuss the incidence, recurrence rates, mortality rates, and risk factors associated with cSCC and review the staging systems used to stratify patients into high- and low-risk groups...
February 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29327047/histopathological-and-inflammatory-features-of-chronically-discharging-open-mastoid-cavities-secondary-analysis-of-a-randomized-clinical-trial
#5
Darius Henatsch, Sultan Alsulami, Adriaan M Duijvestijn, Jack P Cleutjens, Carine J Peutz-Kootstra, Robert J Stokroos
Importance: Many patients with an open radical mastoid cavity experience therapy-resistant otorrhea. Little is known about the underlying histopathological substrate of unstable cavities and the correlation with treatment failure. Objective: To study the histopathological and inflammatory features of chronically discharging open radical mastoid cavities and the influence of different treatments. Design, Setting, and Participants: This secondary analysis of a randomized clinical trial was a histopathology study of tissue samples of a cohort of 30 patients with a chronically discharging open mastoid cavity...
January 11, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29312594/investigation-of-tcf7l2-lep-and-lepr-polymorphisms-with-esophageal-squamous-cell-carcinomas
#6
Hao Qiu, Xunting Lin, Weifeng Tang, Chao Liu, Yu Chen, Hao Ding, Mingqiang Kang, Shuchen Chen
Single nucleotide polymorphisms (SNPs) in energy metabolism related gene may be key agents in the development of human malignancies. In this study, we aimed to examine the association of transcription factor 7-like 2, Leptin (LEP) and LEP receptor (LEPR) polymorphisms with esophageal squamous cell carcinoma (ESCC). A total of 507 ESCC cases and 1,496 controls were enrolled. We found that LEPR rs6588147 AA genotype was associated with ESCC risk (AA vs. GG/GA: adjusted OR=1.90, 95%CI=1.00-3.61, P=0.049). In the stratified analyses, LEPR rs6588147 G>A polymorphism increased the risk of ESCC (<63 years subgroup: AA vs...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29305708/identification-of-specific-feed-forward-apoptosis-mechanisms-and-associated-higher-survival-rates-for-low-grade-glioma-and-lung-squamous-cell-carcinoma
#7
Dhiraj Sikaria, Yaping N Tu, Diana A Fisler, James A Mauro, George Blanck
The mechanisms of cell proliferation due to the overexpression of certain transcription factors (TFs) have been well documented in the cancer setting. However, many of these same TFs have pro-apoptotic effects, particularly when expressed or activated at high levels, a process referred to as feed-forward apoptosis (FFA). To determine whether cancers could be stratified on the basis of specific FFA signatures, RNASeq data representing samples from the cancer genome atlas were analyzed, revealing that high expression of the pro-proliferative TFs, MYC and YY1, is associated with a favorable outcome in low-grade glioma (LGG) and lung squamous cell carcinoma (LUSC), respectively...
January 5, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29299360/prognostic-relevance-of-human-papillomavirus-infection-in-anal-squamous-cell-carcinoma-analysis-of-the-national-cancer-data-base
#8
Jaymin Jhaveri, Lael Rayfield, Yuan Liu, Mudit Chowdhary, Richard J Cassidy, Nicholas A Madden, Daniel G Tanenbaum, Theresa W Gillespie, Pretesh R Patel, Kirtesh R Patel, Jerome C Landry
Background: To examine the prognostic relevance of human papillomavirus (HPV) infection for anal squamous cell carcinoma (ASCC) patients treated with chemoradiation (CRT) in the National Cancer Data Base (NCDB). Methods: The 2014 NCDB was queried for non-metastatic, histologically confirmed, ASCC patients diagnosed between 2004 and 2013. Patients were required to have HPV status documented in order to be eligible. Patients were then stratified into two groups: HPV+ and HPV-...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29299137/association-of-aldh3b2-gene-polymorphism-and-risk-factors-with-susceptibility-of-esophageal-squamous-cell-carcinoma-in-a-chinese-population-a-case-control-study-involving-2-358-subjects
#9
Jun Yin, Weifeng Tang, Tao Long, Huiwen Pan, Jianchao Liu, Lu Lv, Chao Liu, Yijun Shi, Jingfeng Zhu, Yangyong Sun, Aizhong Shao, Qiang Zhou, Zhengbing Ren, Guowen Ding, Suocheng Chen, Yan Liu, Jun Yao, Hao Ding, Yulan Yan, Haiyong Gu, Cheng Qian, Liming Wang, Qun Wang, Lijie Tan
Background: Esophageal cancer (EC) is the sixth leading cause of cancer-associated death worldwide. The interaction of environmental risk factors and genetic factors might contribute to the carcinogenesis of EC synergistically. Results: All seven single locus polymorphisms of ALDH3B2 were not associated with risk of ESCC as evaluated by allelic, dominant, co-dominant, recessive and Cochran-Armitage trend tests. Stratified analyses showed these SNPs were not correlated with the susceptibility of ESCC according to different age, gender, cigarette smoking and alcohol drinking status...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29298797/development-and-validation-of-a-gene-signature-for-patients-with-head-and-neck-squamous-cell-carcinomas-treated-by-postoperative-radio-chemo-therapy
#10
Stefan Schmidt, Annett Linge, Alex Zwanenburg, Stefan Leger, Fabian Lohaus, Constanze Krenn, Steffen Appold, Volker Gudziol, Alexander Nowak, Clare von Neubeck, Ingeborg Tinhofer, Volker Budach, Ali Sak, Martin Stuschke, Panagiotis Balermpas, Claus Rödel, Hatice Bunea, Anca Ligia Grosu, Amir Abdollahi, Juergen Debus, Ute Ganswindt, Claus Belka, Steffi U Pigorsch, Stephanie Elisabeth Combs, David Mönnich, Daniel Zips, Gustavo B Baretton, Frank Buchholz, Michael Baumann, Mechthild Krause, Steffen Löck
PURPOSE: The aim of this study was to identify and independently validate a novel gene signature predicting loco-regional tumor control (LRC) for treatment individualization of patients with locally advanced HPV-negative head and neck squamous cell carcinomas (HNSCC) who are treated with postoperative radio(chemo)therapy (PORT-C). EXPERIMENTAL DESIGN: Gene expression analyses were performed using nanoString technology on a multicenter training cohort of 130 patients and an independent validation cohort of 121 patients...
January 3, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29286069/a-16-gene-expression-signature-to-distinguish-stage%C3%A2-i-from-stage%C3%A2-ii-lung-squamous-carcinoma
#11
Rui Wang, Yuxing Cai, Baoping Zhang, Zhengxia Wu
The present study aimed to perform screening of a gene signature for the discrimination and prognostic prediction of stage I and II lung squamous carcinoma. A microarray meta‑analysis was performed to identify differentially expressed genes (DEGs) between stage I and II lung squamous carcinoma samples in seven microarray datasets collected from the Gene Expression Omnibus database via the MetaQC and MetaDE package in R. The important DEGs were selected according to the betweenness centrality value of the protein‑protein interaction (PPI) network...
December 19, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29275426/platelet-to-lymphocyte-ratio-predicts-long-term-survival-in-laryngeal-cancer
#12
Yize Mao, Yan Fu, Yunfei Gao, Ankui Yang, Quan Zhang
OBJECTIVES: Although the survival rate of laryngeal cancer is relatively high, some patients with laryngeal squamous cell carcinoma (LSCC) show the least benefit from laryngectomy, owing to few determining diagnostic tools. We aimed to identify high-risk patients according to a preoperatively determined signature of the platelet-to-lymphocyte ratio (PLR) of > 193.55, as an indicator of poor treatment outcome in LSCC patients. METHODS: We retrospectively evaluated 899 patients who underwent laryngectomy for LSCC...
December 23, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29261835/comparison-of-tumor-classifications-for-cutaneous-squamous-cell-carcinoma-of-the-head-and-neck-in-the-7th-vs-8th-edition-of-the-ajcc-cancer-staging-manual
#13
Pritesh S Karia, Frederick C Morgan, Joseph A Califano, Chrysalyne D Schmults
Importance: Previous studies have shown that the AJCC Cancer Staging Manual, 7th edition (AJCC 7), tumor classification for cutaneous squamous cell carcinoma (CSCC) failed to accurately stratify disease-related outcomes. The recently released 8th edition (AJCC 8) features a revised tumor classification for only head and neck CSCC (HNCSCC). Objective: To compare AJCC 7 and AJCC 8 tumor classifications for HNCSCC and to validate AJCC 8. Design, Setting, and Participants: This was a 10-year retrospective cohort study (2000-2009) at an academic tertiary care center reviewing 680 primary HNCSCC tumors in 459 patients...
December 20, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29251330/stmn1-a-prognostic-predictor-of-esophageal-squamous-cell-carcinoma-is-a-marker-of-the-activation-of-the-pi3k-pathway
#14
Wenpeng Jiang, Shiting Huang, Liang Song, Zhou Wang
The esophageal squamous cell carcinoma (ESCC) subtype with STMN1 overexpression has a high likelihood of lymphatic metastatic recurrence. However, the underlying mechanism remains to be further elucidated. We assessed the expression level of STMN1 and PTEN in 96 pN0 ESCC patient tissues using immunohistochemistry and western blot analysis. Then, the association between STMN1 overexpression and postoperative lymphatic metastatic recurrence was evaluated. In addition, the relationship between STMN1 and PTEN was also assessed...
February 2018: Oncology Reports
https://www.readbyqxmd.com/read/29248496/clinical-and-histopathological-features-of-nasopalatine-duct-cyst-a-47-year-retrospective-study-and-review-of-current-concepts
#15
Caio César da Silva Barros, Hellen Bandeira de Pontes Santos, Israel Leal Cavalcante, Larissa Santos Amaral Rolim, Leão Pereira Pinto, Lélia Batista de Souza
PURPOSE: To evaluate the clinical and histopathological features of nasopalatine duct cysts (NDCs) stored in the archives of a referred Oral Pathology Service over a 47-year-period, and to review current concepts about these cysts. MATERIAL AND METHODS: All NDCs were reviewed, and clinical data were obtained from the patient records. Thirty cases were re-evaluated microscopically by 2 oral pathologists. RESULTS: Among 14,564 cases, 30 (0.20%) were NDCs...
December 2, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29239471/age-related-changes-in-the-morphology-and-the-distribution-of-iga-and-igg-in-the-palatine-tonsils-of-yaks-bos-grunniens
#16
Juan Sun, Yuanfang Xu, Yan Cui, Penggang Liu, Sijiu Yu, Junfeng He, Qian Zhang, Yufeng Huang, Xue Yang
This study aimed to describe the age-related morphological changes and the distribution of IgA and IgG antibody-secreting cells (ASCs) in yaks. The palatine tonsils of twenty clinically healthy yaks, viz. newborn juvenile, adult and aged, were studied using histology, immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). The results showed that the palatine tonsils found in two tonsillar sinus were elongated kidney-shaped structures. Some external crypts and internal crypts were present. The palatine tonsils were partially enclosed by a connective tissue capsule and had trabeculae extending into the organ...
December 14, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/29238985/impaired-functional-vitamin-b6-status-is-associated-with-increased-risk-of-lung-cancer
#17
Despoina Theofylaktopoulou, Øivind Midttun, Per M Ueland, Klaus Meyer, Anouar Fanidi, Wei Zheng, Xiao-Ou Shu, Yong-Bing Xiang, Ross Prentice, Mary Pettinger, Cynthia A Thomson, Graham G Giles, Allison Hodge, Qiuyin Cai, William J Blot, Jie Wu, Mikael Johansson, Johan Hultdin, Kjell Grankvist, Victoria L Stevens, Marjorie M McCullough, Stephanie J Weinstein, Demetrius Albanes, Regina Ziegler, Neal D Freedman, Arnulf Langhammer, Kristian Hveem, Marit Naess, Howard D Sesso, J Michael Gaziano, Julie E Buring, I-Min Lee, Gianluca Severi, Xuehong Zhang, Meir J Stampfer, Jiali Han, Stephanie A Smith-Warner, Anne Zeleniuch-Jacquotte, Loic le Marchand, Jian-Min Yuan, Renwei Wang, Lesley M Butler, Woon-Puay Koh, Yu-Tang Gao, Nathaniel Rothman, Ulrika Ericson, Emily Sonestedt, Kala Visvanathan, Miranda R Jones, Caroline Relton, Paul Brennan, Mattias Johansson, Arve Ulvik
Circulating vitamin B6 levels have been found to be inversely associated with lung cancer. Most studies have focused on the B6 form pyridoxal 5'-phosphate (PLP), a direct biomarker influenced by inflammation and other factors. Using a functional B6 marker allows further investigation of the potential role of vitamin B6 status in the pathogenesis of lung cancer. We prospectively evaluated the association of the functional marker of vitamin B6 status, the 3-hydroxykynurenine:xanthurenic acid ratio (HK:XA), with risk of lung cancer in a nested case-control study consisting of 5,364 matched case control pairs from the Lung Cancer Cohort Consortium (LC3)...
December 14, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29232767/a-comparative-immunohistochemical-study-of-anal-canal-epithelium-in-humans-and-swine-focusing-on-the-anal-transitional-zone-epithelium-and-the-anal-glands
#18
Futoshi Muranaka, Tomoyuki Nakajima, Mai Iwaya, Keiko Ishii, Kayoko Higuchi, Naoko Ogiwara, Shinichi Miyagawa, Hiroyoshi Ota
To better understand the cellular origins and differentiation of anal canal epithelial neoplasms, the immunohistochemical profiles of the anal canal epithelium in humans and swine were evaluated. Formalin-fixed tissue sections were immunostained for mucin (MUC: MUC2, MUC5AC, MUC5B), desmoglein 3 (DGS3), p63, CDX2, SOX2, and α-smooth muscle actin (α-SMA). The anal transitional zone (ATZ) epithelium covered the anal sinus and consisted of a stratified epithelium with mucous cells interspersed within the surface lining...
December 12, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29223663/patch-esophagoplasty-using-an-in-body-tissue-engineered-collagenous-connective-tissue-membrane
#19
Hiroomi Okuyama, Satoshi Umeda, Yuichi Takama, Takeshi Terasawa, Yasuhide Nakayama
AIM: Although many approaches to esophageal replacement have been investigated, these efforts have thus far only met limited success. In-body-tissue-engineered connective tissue tubes have been reported to be effective as vascular replacement grafts. The aim of this study was to investigate the usefulness of an In-body-tissue-engineered collagenous connective tissue membrane, "Biosheet", as a novel esophageal scaffold in a beagle model. METHODS: We prepared Biosheets by embedding specially designed molds into subcutaneous pouches in beagles...
November 13, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29217659/rock-dependent-phosphorylation-of-nup62-regulates-p63-nuclear-transport-and-squamous-cell-carcinoma-proliferation
#20
Masaharu Hazawa, De-Chen Lin, Akiko Kobayashi, Yan-Yi Jiang, Liang Xu, Firli Rahmah Primula Dewi, Mahmoud Shaaban Mohamed, Hartono, Mitsutoshi Nakada, Makiko Meguro-Horike, Shin-Ichi Horike, H Phillip Koeffler, Richard W Wong
p63, more specifically its ΔNp63α isoform, plays essential roles in squamous cell carcinomas (SCCs), yet the mechanisms controlling its nuclear transport remain unknown. Nucleoporins (NUPs) are a family of proteins building nuclear pore complexes (NPC) and mediating nuclear transport across the nuclear envelope. Recent evidence suggests a cell type-specific function for certain NUPs; however, the significance of NUPs in SCC biology remains unknown. In this study, we show that nucleoporin 62 (NUP62) is highly expressed in stratified squamous epithelia and is further elevated in SCCs...
December 7, 2017: EMBO Reports
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