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https://www.readbyqxmd.com/read/28231601/early-age-at-first-sexual-intercourse-is-associated-with-higher-prevalence-of-high-grade-squamous-intraepithelial-lesions-hsil
#1
José Cândido Caldeira Xavier-Júnior, Rozany Mucha Dufloth, Diama Bhadra Vale, Marcelo Tavares de Lima, Luiz Carlos Zeferino
Objective To evaluate the association of age at first sexual intercourse with the results of the cervicovaginal cytology. Study Design Observational analytical study about the prevalence of altered cervicovaginal cytology results in women aged between 18 and 34 years from a densely populated area in Brazil, during 10 years. The patients were stratified into 2 categories according to their age at first sexual intercourse (13-16 years and 17-24 years). Results From the total of 2,505,154 exams, 898,921 tests were in accordance with the inclusion criteria...
February 23, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28225789/non-melanoma-skin-cancer-and-risk-of-alzheimer-s-disease-and-all-cause-dementia
#2
Sigrun A J Schmidt, Anne G Ording, Erzsébet Horváth-Puhó, Henrik T Sørensen, Victor W Henderson
Cancer patients may be at decreased risk of Alzheimer's disease. This hypothesis is best developed for non-melanoma skin cancer (NMSC), but supportive epidemiological data are sparse. We therefore conducted a nationwide cohort study of the association between NMSC and Alzheimer's disease (main outcome) and all-cause dementia. Using Danish medical databases, we identified adults diagnosed with NMSC between 1 January 1980 and 30 November 2013 (n = 216,221) and a comparison cohort of five individuals matched to each NMSC patient by sex and birth year (n = 1,081,097)...
2017: PloS One
https://www.readbyqxmd.com/read/28218707/fkbp51-immunohistochemical-expression-a-new-prognostic-biomarker-for-oscc
#3
Daniela Russo, Francesco Merolla, Massimo Mascolo, Gennaro Ilardi, Simona Romano, Silvia Varricchio, Virginia Napolitano, Angela Celetti, Loredana Postiglione, Pier Paolo Di Lorenzo, Luigi Califano, Giovanni Orabona Dell'Aversana, Fabio Astarita, Maria Fiammetta Romano, Stefania Staibano
Up-to-date, several molecular markers of prognosis have been studied in Oral Squamous Cell Carcinoma (OSCC), but none entered in the clinical setting. Therapy of OSCC tumors mainly relies on surgery, radiotherapy and partially on chemotherapy; there is an urgent need for biomarkers able to better stratify OSCC patients' risk to address targeted therapeutic strategies. The role of immune response in the pathogenesis and biological behavior of OSCC has been investigated by several authors, and promising results have been obtained with immune checkpoint inhibitors...
February 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28216507/-a-case-report-for-giant-cholesteatoma-occurred-in-%C3%A2-fronto-parietal-bone
#4
Yu Zhou, Yugang Jiang
Cholesteatoma is a destructive and expanding growth benign tumor, mainly consisting of stratified squamous epithelium. It possesses the capacity of eroding bone and can exist in a nonaggressive state, remaining undetected for years. Once cholesteatoma appeared, it grows relentlessly and threats to invade intra-temporal structures. Most cholesteatomas occurred in the petrous bone and also affected the labyrinth and middle cranial fossa. Here, we report a preliminary wrongly-diagnosed case. The patient was wrongly diagnosed as "sebaceous cyst with infection" by local hospital...
January 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28209236/epithelial-downgrowth-report-of-2-cases-diagnosed-by-ocular-biopsy
#5
REVIEW
Hershel R Patel, Curtis E Margo
Epithelial downgrowth is an uncommon complication of ocular surgery or adverse consequence of accidental trauma, caused by surface squamous epithelium that has gained access to the inner compartments of the eye. Once embedded in the eye, squamous epithelium spreads over contiguous structures, interfering with normal aqueous outflow and vision. The pursuit of improved therapies is ongoing, but the greatest chance of preventing blindness is with early recognition. Two cases of epithelial downgrowth diagnosed from a corneal button and an iris biopsy are presented to familiarize pathologists with this disorder...
February 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28209012/a-case-of-verruciform-xanthoma-arising-in-the-tongue
#6
Yukihiro Hiraishi, Itaru Tojyo, Norifumi Kiga, Koji Tanimoto, Shigeyuki Fujita
Verruciform Xanthoma (VX) is a rare lesion of the oral cavity. Histologically, it is characterized by papillary or verrucous proliferation of squamous epithelium and numerous foam cells. VX arising in the tongue is comparatively rare, as most cases of VX in oral cavity occur in gingiva. A 65-year-old woman was referred to our clinic with a mass on the left side of the tongue. The lesion was yellowish, and its surface was granulated. The patient had neither tenderness nor any symptoms. The lesion was clinically diagnosed to be a benign tumor, and hence, biopsy was performed, according to which it was diagnosed as hyperparakeratosis...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28199962/incorporation-of-the-number-of-positive-lymph-nodes-leads-to-better-prognostic-discrimination-of-node-positive-early-stage-cervical-cancer
#7
Juan Zhou, San-Gang Wu, Jia-Yuan Sun, Xu-Lin Liao, Feng-Yan Li, Huan-Xin Lin, Li-Chao Yang, Zhen-Yu He
To determine the prognostic value of the number of positive lymph nodes (LNs) in cervical cancer and further stratify patients with positive LNs into multiple risk groups based on analysis of Surveillance Epidemiology and End Results (SEER) program. Patients with cervical cancer who undergo hysterectomy and had pathologically-confirmed positive LNs after lymphadenectomy were identified using the SEER database (1988-2012). Kaplan-Meier survival methods and Cox proportional hazards regression were performed. We included 2,222 patients with the median number of removed LNs and positive LNs was 22 and 2, respectively...
February 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28195638/significant-changes-in-sexual-behavior-after-a-diagnosis-of-human-papillomavirus-positive-and-human-papillomavirus-negative-oral-cancer
#8
Miren Taberna, Ronald C Inglehart, Robert K L Pickard, Carole Fakhry, Amit Agrawal, Mira L Katz, Maura L Gillison
BACKGROUND: Sexual behavior and oral human papillomavirus (HPV) infection are risk factors for oral squamous cell carcinoma (OSCC). The effects of OSCC diagnosis and treatment on subsequent relationship stress and sexual behavior are unknown. METHODS: Incident cases of HPV-positive or HPV-negative OSCC in patients who had a partnered relationship and partners of patients with oropharyngeal cancer were eligible for a study in which surveys were administered at diagnosis and at the 6-month follow-up time point to assess relationship distress, HPV transmission and concerns about health consequences, and sexual behavior...
February 14, 2017: Cancer
https://www.readbyqxmd.com/read/28190659/demographic-and-lifestyle-factors-and-survival-among-patients-with-esophageal-and-gastric-cancer-the-biobank-japan-project
#9
Emiko Okada, Shigekazu Ukawa, Koshi Nakamura, Makoto Hirata, Akiko Nagai, Koichi Matsuda, Toshiharu Ninomiya, Yutaka Kiyohara, Kaori Muto, Yoichiro Kamatani, Zentaro Yamagata, Michiaki Kubo, Yusuke Nakamura, Akiko Tamakoshi
BACKGROUND: Several studies have evaluated associations between the characteristics of patients with esophageal and gastric cancer and survival, but these associations remain unclear. We described the distribution of demographic and lifestyle factors among patients with esophageal and gastric cancer in Japan, and investigated their potential effects on survival. METHODS: Between 2003 and 2007, 24- to 95-year-old Japanese patients with esophageal and gastric cancer were enrolled in the BioBank Japan Project...
February 9, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28160562/the-tumor-suppressor-capability-of-p53-is-dependent-on-non-muscle-myosin-iia-function-in-head-and-neck-cancer
#10
Sonya D Coaxum, Jessica Tiedeken, Elizabeth Garrett-Mayer, Jeffrey Myers, Steven A Rosenzweig, David M Neskey
Over 300,000 patients develop squamous cell carcinoma of the head and neck (HNSCC) worldwide with 25-30% of patients ultimately dying from their disease. Currently, molecular biomarkers are not used in HNSCC but several genes have been identified including mutant TP53 (mutp53). Our recent work has identified an approach to stratify patients with tumors harboring high or low risk TP53 mutations. Non-muscle Myosin IIA (NMIIA) was recently identified as a tumor suppressor in HNSCC. We now demonstrate that low MYH9 expression is associated with decreased survival in patients with head and neck cancer harboring low-risk mutp53 but not high-risk mutp53...
February 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28160234/morphological-study-of-the-european-hedgehog-erinaceus-europaeus-tongue-by-sem-and-lm
#11
Ghasem Akbari, Mohammad Babaei, Belal Hassanzadeh
The hedgehog tongue is a tactile and taste organ which carries out various functions. Detailed functional and morphological studies are required to clearly define the relationship of the hedgehog tongue with taste, food palatability, mastication and swallowing of food, as well as the production of sounds. The aim of this study was to determine the relationship between the morphological characteristics of the European hedgehog tongue and the lifestyle of this animal, as well as to compare findings with the results of studies on other vertebrates...
February 3, 2017: Anatomical Science International
https://www.readbyqxmd.com/read/28152979/the-important-role-of-circulating-cyfra21-1-in-metastasis-diagnosis-and-prognostic-value-compared-with-carcinoembryonic-antigen-and-neuron-specific-enolase-in-lung-cancer-patients
#12
Li Zhang, Dan Liu, Lei Li, Dan Pu, Ping Zhou, Yuting Jing, He Yu, Yanwen Wang, Yihan Zhu, Yanqi He, Yalun Li, Shuang Zhao, Zhixin Qiu, Weimin Li
BACKGROUND: The roles of carcinoembryonic antigen (CEA), cytokeratin 19 fragments (CYFRA21-1) and neuron-specific enolase (NSE) in metastases occurrence and poor diagnosis in specific histological classifications of lung cancer need further exploring. In this study, we investigated relationship between elevated levels of three biomarkers of CEA, CYFRA21-1 and NSE (individually and in combination) and metastasis, survival status and prognosis in lung cancer patients. METHODS: Eight hundred and sixty eight lung cancer patients including adenocarcinoma (ADC, N = 445), squamous cell carcinoma (SCC, N = 215), small cell lung cancer (SCLC, N = 159) and other types (N = 49) were categorized into negative, moderate and high groups according to serum levels of biomarkers, and were then categorized into negative, single, double and triple groups according to any positive combination of three biomarkers...
February 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28152570/niacin-intake-and-risk-of-skin-cancer-in-us-women-and-men
#13
Sang Min Park, Tricia Li, Shaowei Wu, Wen-Qing Li, Martin Weinstock, Abrar A Qureshi, Eunyoung Cho
A recent clinical trial found a protective role of niacinamide, a derivative of niacin, against skin cancer recurrence. However, there is no epidemiologic study to assess the association between niacin intake and risk of skin cancer (basal cell carcinoma [BCC], squamous cell carcinoma [SCC], and melanoma). We prospectively evaluated whether total, dietary and supplemental niacin intake was associated with skin cancer risk based on 72,308 women in the Nurses' Health Study (1984-2010) and 41,808 men in the Health Professionals Follow-up Study (1986-2010)...
February 2, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28150306/adjuvant-radiotherapy-is-not-supported-in-patients-with-verrucous-carcinoma-of-the-oral-cavity
#14
Suresh Mohan, Sara I Pai, Neil Bhattacharyya
OBJECTIVE: To analyze the impact of adjuvant radiation therapy (RT) on overall survival (OS) and disease-specific survival (DSS) in patients with verrucous carcinoma (VC) as compared to squamous cell carcinoma (SCC) of the oral cavity. STUDY DESIGN: Cross-sectional population analysis. METHODS: Cases of nonmetastatic VC/SCC of the oral cavity were extracted from the Surveillance, Epidemiology, and End Results (SEER) database (1988-2013). Kaplan-Meier survivals, stratified according to T stage, were compared between VC and SCC for treatment with or without adjuvant RT...
February 1, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28147340/proposed-modifications-of-supraclavicular-lymph-node-metastasis-in-the-esophageal-squamous-cell-carcinoma-staging-system-for-improved-survival-stratification
#15
Yuzhen Zheng, Zhen Wang, Feng Wang, Qingyuan Huang, Shuoyan Liu
The present study aims to investigate the clinical implication of supraclavicular lymph nodes (SCLNs) in thoracic esophageal squamous cell carcinoma (ESCC). A total of 1156 ESCC patients who underwent three-field lymphadenectomy with node metastasis were analyzed retrospectively. SCLNs were defined as regional nodes in the current system or as distant nodes in the modified system. Survival was analyzed using the Kaplan-Meier method, and values were compared using the log-rank test. Multivariate analysis was performed using the Cox proportional hazard model...
January 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28137717/differentiated-state-of-initiating-tumor-cells-is-key-to-distinctive-immune-responses-seen-in-h-rasg12v-induced-squamous-tumors
#16
Michael A Podolsky, Jacob T Bailey, Andrew J Gunderson, Carrie J Oakes, Kyle Breech, Adam B Glick
Heterogeneity in tumor immune responses is a poorly understood yet critical parameter for successful immunotherapy. In two doxycycline-inducible models where oncogenic H-Ras(G12V) is targeted either to the epidermal basal/stem cell layer with a Keratin14-rtTA transgene (K14Ras), or committed progenitor/suprabasal cells with an Involucrin-tTA transgene (InvRas) we observed strikingly distinct tumor immune responses. On threshold doxycycline levels yielding similar Ras expression, tumor latency, and numbers, tumors from K14Ras mice had an immunosuppressed microenvironment while InvRas tumors had a pro-inflammatory microenvironment...
January 30, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28126333/first-line-ceritinib-versus-platinum-based-chemotherapy-in-advanced-alk-rearranged-non-small-cell-lung-cancer-ascend-4-a-randomised-open-label-phase-3-study
#17
Jean-Charles Soria, Daniel S W Tan, Rita Chiari, Yi-Long Wu, Luis Paz-Ares, Juergen Wolf, Sarayut L Geater, Sergey Orlov, Diego Cortinovis, Chong-Jen Yu, Maximillian Hochmair, Alexis B Cortot, Chun-Ming Tsai, Denis Moro-Sibilot, Rosario G Campelo, Tracey McCulloch, Paramita Sen, Margaret Dugan, Serafino Pantano, Fabrice Branle, Cristian Massacesi, Gilberto de Castro
BACKGROUND: The efficacy of ceritinib in patients with untreated anaplastic lymphoma kinase (ALK)-rearranged non-small-cell lung cancer (NSCLC) is not known. We assessed the efficacy and safety of ceritinib versus platinum-based chemotherapy in these patients. METHODS: This randomised, open-label, phase 3 study in untreated patients with stage IIIB/IV ALK-rearranged non-squamous NSCLC was done in 134 centres across 28 countries. Eligible patients were assigned via interactive response technology to oral ceritinib 750 mg/day or platinum-based chemotherapy ([cisplatin 75 mg/m(2) or carboplatin AUC 5-6 plus pemetrexed 500 mg/m(2)] every 3 weeks for four cycles followed by maintenance pemetrexed); randomisation was stratified by World Health Organization performance status (0 vs 1-2), previous neoadjuvant or adjuvant chemotherapy, and presence of brain metastases as per investigator's assessment at screening...
January 23, 2017: Lancet
https://www.readbyqxmd.com/read/28125757/prognostic-performance-of-a-new-staging-category-to-improve-discrimination-of-disease-specific-survival-in-nonmetastatic-oral-cancer
#18
Ching-Chih Lee, Chien-Yu Huang, Yaoh-Shinag Lin, Kuo-Ping Chang, Chao-Chuan Chi, Ming-Yee Lin, Hsing-Hao Su, Ting-Shou Chang, Hung-Chih Chen, Ching-Chieh Yang
Importance: Inflammatory status is associated with outcome in oral squamous cell carcinoma (OSCC). Combining the preoperative neutrophil to lymphocyte ratio (NLR) and histopathologic features may provide clinicians with more exact information regarding the prognosis of OSCC. Objective: To compare the prognostic performance of the routinely used pathologic TNM staging with a new staging category that incorporates the NLR and histopathologic features. Design, Setting, and Participants: This retrospective cohort study included 396 patients with newly diagnosed OSCC who underwent major surgery at a medical center from January 1, 2006, through December 31, 2013...
January 26, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28122353/matched-pair-analysis-of-survival-in-patients-with-poorly-differentiated-versus-well-differentiated-glottic-squamous-cell-carcinoma
#19
Ping Chen, Wenbin Yu, Junwei Huang, Hongbo Xu, Guojun Li, Xiaohong Chen, Zhigang Huang
To compare survival outcomes between patients with poorly differentiated versus well-differentiated glottic squamous cell carcinoma (GSCC). Fifty-five patients with well-differentiated newly diagnosed GSCC were pair-matched to 55 patients with poorly differentiated GSCC according to age, sex, year of diagnosis, overall stage, treatment (surgery type, neck dissection, surgical margin, and chemoradiation), smoking, and alcohol use. Survival analysis was performed using Kaplan-Meier estimates, and matched-pair survival was estimated using the Cox proportional hazards regression model...
January 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28120093/role-of-postoperative-c-reactive-protein-levels-in-predicting-prognosis-after-surgical-treatment-of-esophageal-cancer
#20
Yuta Ibuki, Yoichi Hamai, Jun Hihara, Manabu Emi, Junya Taomoto, Takaoki Furukawa, Ichiko Yamakita, Tomoaki Kurokawa, Morihito Okada
BACKGROUND: Elevated preoperative serum C-reactive protein (CRP) levels are reportedly associated with a poor prognosis for patients with various types of malignant tumors. However, the impact of postoperative CRP levels on the prognosis of patients with esophageal cancer remains unknown. The present study aims to clarify the prognostic significance of postoperative CRP levels on the survival of patients with esophageal cancer. METHODS: We reviewed the records of consecutive 202 patients with thoracic esophageal squamous cell carcinoma who underwent transthoracic esophagectomy...
January 24, 2017: World Journal of Surgery
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