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https://www.readbyqxmd.com/read/28920797/description-of-gastric-ulcers-and-of-their-suspected-associated-risk-factors-in-deceased-wild-equids-at-the-r%C3%A3-serve-africaine-de-sigean-france-2010-2016
#1
Benjamin Lamglait, Marielle Vandenbunder-Beltrame, Elodie Trunet, Karin Lemberger
Gastric ulcers are common in domestic horses and foals, affecting at least 90% of unmedicated racehorses in active training. Despite these high prevalences in domestic horses, literature about this condition in wild equids is almost nonexistent. The presence of gastric ulcers was evaluated at necropsy in six species of wild equids that died at the Réserve Africane de Sigean, a safari park in the south of France from 2010 to 2016. Among the 55 individuals that died during that period, a description of the gastric mucosa was available in 82% (45/55) of cases...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28900998/-associated-factors-of-postoperative-relapse-and-metastasis-in-pt1bn0m0-pt4an0m0-thoracic-esophageal-squamous-cell-carcinoma
#2
Wenbiao Pan, Yangwei Xiang, Zhitao Gu, Chunyu Ji, Teng Mao, Wentao Fang
OBJECTIVE: To investigate the associated high risk factors of postoperative relapse and metastasis for patients with confined tumors (grade pT1b-4a) without lymph-node metastases (pN0) in thoracic esophageal squamous cell carcinoma (ESCC). METHODS: Clinicopathological and follow up data of ESCC patients undergoing radical surgical resection as primary treatment in the Department of Thoracic Surgery, Shanghai Chest Hospital between January 2004 and December 2012 from Hospital Database were retrospectively collected...
September 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28900487/chromosomal-and-genomic-variations-in-esophageal-squamous-cell-carcinoma-a-review-of-technologies-applications-and-prospections
#3
REVIEW
Qi Song, Dongxian Jiang, Haixing Wang, Jie Huang, Yalan Liu, Chen Xu, Yingyong Hou
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors with poor prognosis worldwide. The poor prognosis is due to the advanced stage at the time of diagnosis and the limited clinical staging lacking significant molecular biomarkers to effectively stratify patients for treatment options. As cancer is a disease of genome instability and a resulting of accumulation of genetic alteration, mounting chromosomal and genomic technologies were developed and progressed rapidly which could be used for characterizing patients in genomics level...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28899722/effect-of-nonurothelial-histologic-variants-on-the-outcomes-of-radical-cystectomy-for-nonmetastatic-muscle-invasive-urinary-bladder-cancer
#4
Malte W Vetterlein, Thomas Seisen, Jeffrey J Leow, Mark A Preston, Maxine Sun, David F Friedlander, Christian P Meyer, Felix K-H Chun, Stuart R Lipsitz, Mani Menon, Adam S Kibel, Joaquim Bellmunt, Toni K Choueiri, Quoc-Dien Trinh
INTRODUCTION: Knowledge of the comparative oncologic outcomes of histologic variants after radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC) relies on small case series. We compared the effect of pure squamous cell carcinoma, adenocarcinoma, and neuroendocrine carcinoma compared with pure urothelial carcinoma (PUC) on overall survival (OS) and pathologic tumor, lymph node, and surgical margin status after RC. PATIENTS AND METHODS: Using the National Cancer Database, we retrospectively examined patients undergoing RC for MIBC from 2003 to 2011...
August 24, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28893940/oncogenic-human-papillomaviruses
#5
REVIEW
Alison A McBride
Human papillomaviruses (HPVs) are an ancient group of viruses with small, double-stranded DNA circular genomes. They are species-specific and have a strict tropism for mucosal and cutaneous stratified squamous epithelial surfaces of the host. A subset of these viruses has been demonstrated to be the causative agent of several human cancers. Here, we review the biology, natural history, evolution and cancer association of the oncogenic HPVs.This article is part of the themed issue 'Human oncogenic viruses'.
October 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28891852/condyloma-acuminatum-anal-intraepithelial-neoplasia-and-anal-cancer-in-the-setting-of-hiv-do-we-really-understand-the-risk
#6
Edward A Fazendin, Alexander J Crean, Jessica M Fazendin, Robert J Kucejko, Harkenwar S Gill, Juan L Poggio, David E Stein
BACKGROUND: The gold standard for surveillance of patients with anal lesions is unclear. OBJECTIVE: The aim of this study was to stratify patients for risk of progression of disease and to determine appropriate intervals for surveillance of patients with anal disease. DESIGN: This was a retrospective chart review for patients treated for anal lesions between 2007 and 2014. Only patients with ≥1 year of follow-up from index evaluation, pathology, documented physical examination, and anoscopy findings were included for analysis...
October 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28891127/helicobacter-pylori-gastric-cancer-and-other-gastrointestinal-malignancies
#7
REVIEW
Marino Venerito, Riccardo Vasapolli, Theodore Rokkas, Jean-Charles Delchier, Peter Malfertheiner
In a retrospective study performed in California, U.S.A., ca. 3% of patients with gastric intestinal metaplasia (GIM) developed gastric cancer (GC) within a median time period of 4.6 years after diagnosis of GIM. This observation stresses the importance of targeted surveillance even in regions with a low GC prevalence. Patients with alcoholic liver disease as well as survivors of colorectal and lobular breast cancer were found to be at increased risk of secondary GC. A population-based Chinese study confirmed "serologic biopsy" as a useful screening tool for stratifying the individual risk of developing GC...
September 2017: Helicobacter
https://www.readbyqxmd.com/read/28884821/associations-between-intratumoral-and-peritumoral-m2-macrophage-counts-and-cervical-squamous-cell-carcinoma-invasion-patterns
#8
Yuan Li, Gaosheng Huang, Shaohua Zhang
OBJECTIVE: To study the correlation between M2 tumor-associated macrophages (TAMs) and invasion patterns in cervical squamous cell carcinoma (SCC) tissues. METHODS: In the present observational study, two commercial SCC tissue microarrays were evaluated by immunohistochemical analysis between January 1, 2016, and December 31, 2016. CD163-positive cells in a cervical SCC tissue microarray were identified. Tissue samples were stratified into groups based on a pushing border pattern (PBP), a diffuse infiltration pattern (DIP), or non-tumorous tissues included as a control group; M2 TAM numbers and distributions were compared...
September 8, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28882673/predictive-factors-for-local-recurrence-after-glansectomy-and-neoglans-reconstruction-for-penile-squamous-cell-carcinoma
#9
Maarten Albersen, Arie Parnham, Steven Joniau, Varun Sahdev, Michelle Christodoulidou, Fabio Castiglione, Raj Nigam, Peter Malone, Alex Freeman, Charles Jameson, Suks Minhas, David J Ralph, Asif Muneer
OBJECTIVES: To investigate predictive pathological factors for local recurrence (LR) after glansectomy for penile squamous cell carcinoma (SCC) and to develop a risk score for prediction of LR after glansectomy. PATIENTS AND METHODS: In this retrospective study, we analyzed 117 patients operated between February 2005 and January 2016 in a supraregional penile cancer center in the UK for LR after glansectomy and glans reconstruction. Univariate and multivariate Cox proportional hazards regression was used to identify 4 prognostic indicators for LR...
September 4, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28878080/mechanical-barriers-restrict-invasion-of-herpes-simplex-virus-1-into-human-oral-mucosa
#10
Katharina Thier, Philipp Petermann, Elena Rahn, Daniel Rothamel, Wilhelm Bloch, Dagmar Knebel-Mörsdorf
Oral mucosa is one of the main target tissues of the human pathogen herpes simplex virus 1 (HSV-1). How the virus overcomes the protective epithelial barriers and penetrates into the tissue to reach its receptors and initiate infection is still unclear. Here, we established an ex vivo infection assay with human oral mucosa which allows viral entry studies in a natural target tissue. The focus was on the susceptibility of keratinocytes in the epithelium, and the characterization of cellular receptors that mediate viral entry...
September 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28868229/a-very-unlikely-finding-in-a-male-child-urethral-prolapse
#11
Çiğdem Ulukaya Durakbaşa, Gonca Gercel, Murat Huseyin Mutus, Burhan Aksu, Seyma Ozkanli
Urethral prolapse is a disease of prepubertal black girls and postmenopausal women with an unknown cause. It may be congenital in origin or an acquired condition. It has never been reported in males. We report a 10-year-old Caucasian boy who presented because of recurrent right undescended testis. He had been operated on for bilateral undescended testes 7 years ago in another hospital, and circumcision was done during the same operation. The boy complained of a weak urinary stream during voiding. The physical examination was consistent with recurrent right undescended testis...
January 2017: European Journal of Pediatric Surgery Reports
https://www.readbyqxmd.com/read/28855683/tracheal-reconstruction-with-a-free-vascularized-myofascial-flap-preclinical-investigation-in-a-porcine-model-to-human-clinical-application
#12
Won Shik Kim, Jae Won Chang, Woo Soon Jang, Young Joon Seo, Mi-Lan Kang, Hak-Joon Sung, Da Hee Kim, Jung Min Kim, Jae Hong Park, Myung Jin Ban, Gina Na, Seung Ho Shin, Hyung Kwon Byeon, Yoon Woo Koh, Se-Heon Kim, Hong Koo Baik, Eun Chang Choi
Although there are various methods for tracheal reconstruction, such as a simple approximation with suturing and coverage with adjacent soft tissue or muscle, large defects >50% of the tracheal length still present a clinical challenge. Tissue engineering, a recent promising way to possibly resolve this problem, requires a long preparatory period for stem cell seeding on a scaffold and relatively invasive procedures for stem cell harvesting. As an alternative, we used a vascularized myofascial flap for tracheal reconstruction...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28852126/decrease-of-fstl1-bmp4-smad-signaling-predicts-poor-prognosis-in-lung-adenocarcinoma-but-not-in-squamous-cell-carcinoma
#13
Jean Chiou, Chia-Yi Su, Yi-Hua Jan, Chih-Jen Yang, Ming-Shyan Huang, Yung-Luen Yu, Michael Hsiao
Follistatin-related protein 1 (FSTL1) plays a critical role in lung development through regulating BMP4-p-Smad1/5/8-Smad4 pathway. Regarding that many developmental pathways in embryogenesis are dysregulated in cancer, we aim to unravel the role of FSTL1-BMP4-Smad pathway in lung cancer. Our results showed low FSTL1 immunoexpression was significantly correlated with poor prognosis while patients with low BMP4 or low Smad4 immunoexpression showed a trend toward poor prognosis. When stratified by different histological types, low FSTL1, BMP4, and Smad4 expression retained their trends in predicting poor prognosis in lung adenocarcinoma (LUAD) but not in lung squamous cell carcinoma (SCC)...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28843726/residual-tumour-hypoxia-in-head-and-neck-cancer-patients-undergoing-primary-radiochemotherapy-final-results-of-a-prospective-trial-on-repeat-fmiso-pet-imaging
#14
Steffen Löck, Rosalind Perrin, Annekatrin Seidlitz, Anna Bandurska-Luque, Sebastian Zschaeck, Klaus Zöphel, Mechthild Krause, Jörg Steinbach, Jörg Kotzerke, Daniel Zips, Esther G C Troost, Michael Baumann
BACKGROUND: Hypoxia is a well recognised parameter of tumour resistance to radiotherapy, a number of anticancer drugs and potentially immunotherapy. In a previously published exploration cohort of 25 head and neck squamous cell carcinoma (HNSCC) patients on [(18)F]fluoromisonidazole positron emission tomography (FMISO-PET) we identified residual tumour hypoxia during radiochemotherapy, not before start of treatment, as the driving mechanism of hypoxia-mediated therapy resistance. Several quantitative FMISO-PET parameters were identified as potential prognostic biomarkers...
August 23, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28843271/vitamin-d-proliferates-vaginal-epithelium-through-rhoa-expression-in-postmenopausal-atrophic-vagina-tissue
#15
Arum Lee, Man Ryul Lee, Hae-Hyeog Lee, Yeon-Suk Kim, Jun-Mo Kim, Temuulee Enkhbold, Tae-Hee Kim
Postmenopausal atrophic vagina (PAV) is the thinning of the walls of the vagina and decreased lugae of the vagina. PAV is caused by decreased estrogen levels in postmenopausal women. However, the harmful effects of hormone replacement therapy (HRT) have resulted in considerable caution in its use. Various estrogen agonist treatment options are available. Vitamin D is influences the regulation of differentiation and proliferation of various cells, especially tissues lining stratified squamous epithelium, such as the vaginal epithelium...
August 25, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28840766/immunohistochemical-and-molecular-imaging-biomarker-signature-for-the-prediction-of-failure-site-after-chemoradiation-for-head-and-neck-squamous-cell-carcinoma
#16
Gregers Brünnich Rasmussen, Katrin E Håkansson, Ivan R Vogelius, Jacob H Rasmussen, Jeppe T Friborg, Barbara M Fischer, Lisa Schumaker, Kevin Cullen, Marianne H Therkildsen, Søren M Bentzen, Lena Specht
OBJECTIVE: To identify a failure site-specific prognostic model by combining immunohistochemistry (IHC) and molecular imaging information to predict long-term failure type in squamous cell carcinoma of the head and neck. PATIENT AND METHODS: Tissue microarray blocks of 196 head and neck squamous cell carcinoma cases were stained for a panel of biomarkers using IHC. Gross tumor volume (GTV) from the PET/CT radiation treatment planning CT scan, maximal Standard Uptake Value (SUVmax) of fludeoxyglucose (FDG) and clinical information were included in the model building using Cox proportional hazards models, stratified for p16 status in oropharyngeal carcinomas...
August 25, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28837620/extranodal-spread-of-primary-and-secondary-metastatic-nodes-the-dominant-risk-factor-of-survival-in-patients-with-head-and-neck-squamous-cell-carcinoma
#17
Misa Sumi, Shuntaro Sato, Takashi Nakamura
Extranodal spread (ENS) in patients with head and neck squamous cell carcinoma (HNSCC) can greatly influence the prognostic outcomes. However, the relative risks of ENS in the primary (1st) and secondary (2nd) metastatic nodes (mets) are not well documented. We retrospectively analyzed the hazard ratios (HRs) of ENS in the 1st and 2nd mets from 516 HNSCC patients who had undergone primary tumor excision. The impact of clinically and/or histologically confirmed ENS-positive mets on prognosis in terms of cancer-specific survival was analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28832659/racial-disparities-in-cancer-related-survival-in-patients-with-squamous-cell-carcinoma-of-the-esophagus-in-the-us-between-1973-and-2013
#18
Alice Kim, Peter Ashman, Melissa Ward-Peterson, Juan Manuel Lozano, Noël C Barengo
BACKGROUND: Esophageal cancer makes up approximately 1% of all diagnosed cancers in the US. There is a persistent disparity in incidence and cancer-related mortality rates among different races for esophageal squamous cell carcinoma (SCC). Most previous studies investigated racial disparities between black and white patients, occasionally examining disparities for Hispanic patients. Studies including Asians/Pacific Islanders (API) as a subgroup are rare. Our objective was to determine whether there is an association between race and cancer-related survival in patients with esophageal SCC...
2017: PloS One
https://www.readbyqxmd.com/read/28819381/low-preoperative-albumin-to-globulin-ratio-predict-poor-survival-and-negatively-correlated-with-fibrinogen-in-resectable-esophageal-squamous-cell-carcinoma
#19
Xiao-Hui Li, Wen-Shen Gu, Xue-Ping Wang, Jian-Hua Lin, Xin Zheng, Lin Zhang, Ting Kang, Zhi-Xian Zhang, Wan-Li Liu
Background: Although various inflammation-based indexes in esophageal carcinoma have been documented, but the prognostic value of the albumin-to-globulin ratio(AGR) and its correlation with fibrinogen in resectable ESCC remain unknown. Methods: The levels of pre-treatment serum common acute phase proteins (including CRP, albumin and fribrinogen) were retrospectively analyzed in 447 patients with ESCC who underwent surgical resection at our department. The prognostic value was explored by univariate and multivariate cox hazard analysis...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28818536/glansectomy-as-primary-management-of-penile-squamous-cell-carcinoma-an-international-study-collaboration
#20
Dominic H Tang, Sylvia Yan, Sarah R Ottenhof, Désirée Draeger, Adam S Baumgarten, Juan Chipollini, Chris Protzel, Yao Zhu, Ding-Wei Ye, Oliver W Hakenberg, Simon Horenblas, Nicholas A Watkin, Philippe E Spiess
OBJECTIVE: To analyze the recurrence and survival outcomes of glansectomy in patients with penile squamous cell carcinoma. MATERIALS AND METHODS: We performed a retrospective review of 410 patients across 5 international tertiary referral centers between 1999 and 2016. All patients had tumors involving the glans penis and underwent glansectomy as primary treatment. The Kaplan-Meier method and log-rank test were used to calculate survival and recurrence. Median follow-up was 42 months (IQR 29-56)...
August 14, 2017: Urology
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