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https://www.readbyqxmd.com/read/29452074/differential-control-of-appetitive-and-consummatory-sexual-behavior-by-neuroestrogens-in-male-quail
#1
REVIEW
Charlotte A Cornil, Gregory F Ball, Jacques Balthazart
Estrogens exert pleiotropic effects on multiple physiological and behavioral traits including sexual behavior. These effects are classically mediated via binding to nuclear receptors and subsequent regulation of target gene transcription. Estrogens also affect neuronal activity and cell-signaling pathways via faster, membrane-initiated events. Although the distinction between appetitive and consummatory aspects of sexual behavior has been criticized, this distinction remains valuable in that it facilitates the causal analysis of certain behavioral systems...
February 13, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29452001/sexual-behavior-with-noncommercial-partners-a-concurrent-partnership-study-among-middle-aged-female-sex-workers-in-china
#2
Jennifer Guida, Liangyuan Hu, Hongjie Liu
Female sex workers (FSWs) often engage in concurrent partnerships, meaning they have multiple sexual relationships at the same time. The objective of this study was to investigate sexual concurrency and its associations with condom use and syphilitic infections among FSWs over age 35. Respondent-driven sampling was used to recruit 1,245 FSWs in Nanning, Hefei, and Qingdao, China. FSWs were asked to report whether they had concurrent partners in the past six months. Concurrency was defined as engagement in sex with commercial clients and (1) husbands and boyfriends (n = 167); (2) husbands only (n = 301); or (3) boyfriends only (n = 469)...
February 16, 2018: Journal of Sex Research
https://www.readbyqxmd.com/read/29451887/evaluating-diagnostic-indicators-of-urogenital-schistosoma-haematobium-infection-in-young-women-a-cross-sectional-study-in-rural-south-africa
#3
Hashini Nilushika Galappaththi-Arachchige, Sigve Holmen, Artemis Koukounari, Elisabeth Kleppa, Pavitra Pillay, Motshedisi Sebitloane, Patricia Ndhlovu, Lisette van Lieshout, Birgitte Jyding Vennervald, Svein Gunnar Gundersen, Myra Taylor, Eyrun Floerecke Kjetland
BACKGROUND: Urine microscopy is the standard diagnostic method for urogenital S. haematobium infection. However, this may lead to under-diagnosis of urogenital schistosomiasis, as the disease may present itself with genital symptoms in the absence of ova in the urine. Currently there is no single reliable and affordable diagnostic method to diagnose the full spectrum of urogenital S. haematobium infection. In this study we explore the classic indicators in the diagnosis of urogenital S...
2018: PloS One
https://www.readbyqxmd.com/read/29451821/protection-from-vascular-dysfunction-in-female-rats-with-chronic-stress-and-depressive-symptoms
#4
Steven D Brooks, Stan Hileman, Paul D Chantler, Samantha Milde, Kent C Lemaster, Stephanie Frisbee, J Kevin Shoemaker, Dwayne N Jackson, Jefferson C Frisbee
The increasing prevalence and severity of clinical depression is strongly correlated with vascular disease risk, creating a comorbid condition with poor outcomes, although demonstrating a sexual disparity where females are at lower risk than males for subsequent cardiovascular events. To determine potential mechanisms responsible for this protection against stress/depression-induced vasculopathy in females, we exposed male and female ({plus minus}ovariectomy) rats to the unpredictable chronic mild stress (UCMS) model for 8 weeks and determined depressive symptom severity, vascular reactivity in aortic rings (AR) and ex vivo middle cerebral arteries (MCA), and determined the profile of major metabolites regulating vascular tone...
February 16, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29451224/hypogonadism-in-male-thalassemia-major-patients-pathophysiology-diagnosis-and-treatment
#5
Vincenzo De Sanctis, Ashraf T Soliman, Mohamed A Yassin, Salvatore Di Maio, Shahina Daar, Heba Elsedfy, Nada Soliman, Christos Kattamis
Failure of pubertal growth, delay or absence of sexual development, infertility and sexual dysfunction due to hypogonadism and defective spermatogenesis are frequent and well recognized disturbances among male patients with transfusion dependent (TD) thalassaemia major (β-thal). These problems are attributed mainly to the damage caused by chronic anaemia and the deposition of excess iron in the pituitary gland and testicles. This is a short review of male pubertal disorders in patients with β-thal written by pediatric endocrinologists and haematologists with an interest and active involvement, in the diagnosis and management of these complications in this group of patients...
February 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29449942/epidemic-potential-by-sexual-activity-distributions
#6
James Moody, Jimi Adams, Martina Morris
For sexually transmitted infections like HIV to propagate through a population, there must be a path linking susceptible cases to currently infectious cases. The existence of such paths depends in part on the degree distribution. Here, we use simulation methods to examine how two features of the degree distribution affect network connectivity: Mean degree captures a volume dimension, while the skewness of the upper tail captures a shape dimension. We find a clear interaction between shape and volume: When mean degree is low, connectivity is greater for long-tailed distributions, but at higher mean degree, connectivity is greater in short-tailed distributions...
December 2017: Network Science
https://www.readbyqxmd.com/read/29449038/one-year-daily-changes-in-fecal-sexual-steroids-of-two-captive-female-cheetahs-acinonyx-jubatus-in-italy
#7
Valentina Vernocchi, Maria Giorgia Morselli, Massimo Faustini, Gianfranco Gabai, Laura Da Dalt, Gaia Cecilia Luvoni
The present study evaluated changes of fecal sexual steroids in two female cheetahs (Geijsha and Duchessa) in Northern Italy throughout one year. Wet feces were collected daily from two sibling animals of the same age, housed with conspecific males and managed in the same conditions, and estrogens and progestogens concentrations were analyzed by radioimmunoassay (RIA). Evidence of ovarian activity based on regular fluctuation in estrogen excretion was demonstrated in both females. None of the animals was continuously cycling, as follicular activity was interrupted by anestrous periods, during the spring and early winter...
February 2, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29448047/genital-lubrication-a-cue-specific-sexual-response
#8
Megan L Sawatsky, Samantha J Dawson, Martin L Lalumière
Women's genital responses are sensitive to the presence and intensity of sexual cues, yet some stimulus features (e.g., male vs. female actors, consensual vs. non-consensual interactions) have little influence on the magnitude of response-a phenomenon called low cue-specificity. Genital responses are typically assessed using vaginal photoplethysmography, a measure of vaginal vasocongestion, itself a precursor to lubrication. One explanation for low cue-specificity is the preparation hypothesis: Women genitally respond to almost all sexual cues because lubrication functions to protect genital organs from potential injury should vaginal penetration occur...
February 12, 2018: Biological Psychology
https://www.readbyqxmd.com/read/29446809/cost-of-common-low-back-pain-and-lumbar-radiculopathy-in-rheumatologic-consultation-in-lom%C3%A3
#9
Eyram Fianyo, Owonayo Oniankitan, C Tagbor Komi, Kodjo Kakpovi, Prénam Houzou, E S Koffi-Tessio Viwalé, Moustafa Mijiyawa
BACKGROUND: The cost of low back pain was the subject of few studies in black Africa. AIM: To assess the cost of common low back pain and lumbar radiculopathy in Lomé. METHODS: A six months study was realised in the rheumatologic department of CHU Sylvanus Olympio. 103 consecutive patients suffering from a common low back pain or lumbar radiculopathy were included. To assess direct, indirect and non-financial costs they were questioned about their expense during the year...
March 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29445187/adult-male-mice-exposure-to-nonylphenol-alters-courtship-vocalizations-and-mating
#10
Daphné Capela, Carlos Dombret, Kevin Poissenot, Manon Poignant, Aude Malbert-Colas, Isabelle Franceschini, Matthieu Keller, Sakina Mhaouty-Kodja
The neural circuitry processing male sexual behavior is tightly regulated by testosterone and its neural metabolite estradiol. The present study evaluated the effects of adult exposure to low doses of nonylphenol (NP), a widespread environmental contaminant, on the neuroendocrine regulation of testosterone and expression of sexual behavior. Oral exposure of C57BL/6J males to NP (0.5, 5 or 50 μg/kg/day) for 4 weeks did not affect circulating levels of testosterone or the kisspeptin system, a key regulator of the gonadotropic axis...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29445043/vestigial-singing-behaviour-persists-after-the-evolutionary-loss-of-song-in-crickets
#11
Will T Schneider, Christian Rutz, Berthold Hedwig, Nathan W Bailey
The evolutionary loss of sexual traits is widely predicted. Because sexual signals can arise from the coupling of specialized motor activity with morphological structures, disruption to a single component could lead to overall loss of function. Opportunities to observe this process and characterize any remaining signal components are rare, but could provide insight into the mechanisms, indirect costs and evolutionary consequences of signal loss. We investigated the recent evolutionary loss of a long-range acoustic sexual signal in the Hawaiian field cricket Teleogryllus oceanicus Flatwing males carry mutations that remove sound-producing wing structures, eliminating all acoustic signalling and affording protection against an acoustically-orientating parasitoid fly...
February 2018: Biology Letters
https://www.readbyqxmd.com/read/29444746/using-marijuana-drinking-alcohol-or-a-combination-of-both-the-association-of-marijuana-alcohol-and-sexual-risk-behaviour-among-adolescents
#12
Erik D Storholm, Brett A Ewing, Stephanie Brooks Holliday, Bradley D Stein, Lisa S Meredith, William G Shadel, Elizabeth J D'Amico
Background: Although the association between alcohol use and sexual risk behaviour has been well-documented, there is little understanding of whether marijuana use alone or combining marijuana with alcohol use contributes to sexual risk behaviour among adolescents. Methods: A diverse sample of sexually active adolescents (n = 616) aged 12-18 years (50.32% Hispanic; 31.17% Black) completed a survey on alcohol use, marijuana use and sexual risk behaviour during a visit to a primary care clinic. Results: Adolescents were more likely to report having had two or more sexual partners in the past 3 months if they reported using both alcohol and marijuana (OR=3...
February 15, 2018: Sexual Health
https://www.readbyqxmd.com/read/29444462/photodynamic-therapy-as-a-new-approach-to-trichomonas-vaginalis-inactivation
#13
Thaisa Helena Silva Fonseca, Marina Alacoque, Fabrício Marcus Silva Oliveira, Betânia Maria Soares, Henrique Vitor Leite, Marcelo Vidigal Caliari, Maria Aparecida Gomes, Haendel Busatti
The emergence of nitroimidazole resistant isolates has been an aggravating factor in the treatment of trichomoniasis, the most common non-viral sexually transmitted disease in the world. This particularity highlights the importance of new technologies that are safe, effective, and have minor side effects or resistance. Hence, we evaluated the effectiveness of photodynamic therapy on the inactivation of Trichomonas vaginalis in vitro. We used methylene blue as a photosensitizing substance, and a light-emitting diode (LED) for irradiation of metronidazole sensitive and resistant strains...
February 11, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29444242/in-vitro-activity-of-zoliflodacin-etx0914-against-macrolide-resistant-fluoroquinolone-resistant-and-antimicrobial-susceptible-mycoplasma-genitalium-strains
#14
A C Damião Gouveia, M Unemo, J S Jensen
Background: Mycoplasma genitalium is estimated to be the second most common cause of bacterial sexually transmitted infection in Europe. It is of increasing public health concern due to the rapid development of resistance to different antimicrobial classes, including the preferred first- and second-line treatments azithromycin and moxifloxacin. Thus, new antimicrobial agents are urgently needed, especially for the treatment of MDR strains. Methods: The in vitro activity of the new spiropyrimidinetrione zoliflodacin against 47 M...
February 12, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29444073/projected-future-impact-of-hpv-vaccination-and-primary-hpv-screening-on-cervical-cancer-rates-from-2017-2035-example-from-australia
#15
Michaela T Hall, Kate T Simms, Jie-Bin Lew, Megan A Smith, Marion Saville, Karen Canfell
BACKGROUND: Many countries are transitioning from cytology-based to longer-interval HPV screening. Trials comparing HPV-based screening to cytology report an increase in CIN2/3 detection at the first screen, and longer-term reductions in CIN3+; however, population level year-to-year transitional impacts are poorly understood. We undertook a comprehensive evaluation of switching to longer-interval primary HPV screening in the context of HPV vaccination. We used Australia as an example setting, since Australia will make this transition in December 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29440937/a-pilot-study-on-the-functional-performance-and-acceptability-of-an-innovative-female-condom-wondaleaf-%C3%A2-in-malaysia
#16
Rachel Sing-Kiat Ting, Ee-Lynn Wong, Jessie Koh-Sing Tnay
Background: Female condom (FC) has been available for over 30 years, but it still lacks wide acceptability. To overcome misdirection and invagination occurring in FC and to provide a wider area of protection, Wondaleaf ® (WL), a new-generation adhesive FC, was recently invented. This pioneering study sought to assess the acceptability and functional performance of WL among Malaysian women. Methods: A mixed method survey was conducted in three cities of Malaysia, recruiting sexually active heterosexual women, aged 18-50, by snowball sampling method...
2018: Open Access Journal of Contraception
https://www.readbyqxmd.com/read/29440629/the-genotype-of-human-papillomavirus-and-associated-factors-among-high-risk-males-in-shanghai-china-a-molecular-epidemiology-study
#17
Chengzhong Zhang, Chao Zhang, Jie Huang, Weimin Shi
BACKGROUND The aim of this study was to describe the infection rate of human papillomavirus (HPV), its genotype distribution, and associated factors among high-risk males in Shanghai, China. MATERIAL AND METHODS A total of 1,205 participants were enrolled in this study from October 2015 to March 2017. Each individual signed an informed consent before agreeing to take part in this study; participants completed a questionnaire about associated factors related to HPV infection. The HPV GenoArray test kit was used to perform HPV genotyping and was also used in DNA amplification and HybriBio's proprietary flow-through hybridization technique...
February 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29438886/the-influence-of-motives-on-alcohol-and-sex-related-behaviors-among-female-college-students
#18
Brittany E Blanchard, Angela K Stevens, Ileana S Acosta, Amelia E Talley, Jennifer L Brown, Andrew K Littlefield
PURPOSE: Although previous studies have elucidated associations between motivations for drinking and sex as they relate to risky health outcomes among female college students, the utility of cross-domain motives (i.e., alcohol motives predicting sex-related outcomes and vice versa) in the prediction of specific alcohol- and sex-related behaviors has yet to be examined. The current study examined relations between drinking and sex motives with multiple risky alcohol- and sex-related outcomes (i...
February 6, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29438723/discovery-and-development-of-odm-204-a-novel-nonsteroidal-compound-for-the-treatment-of-castration-resistant-prostate-cancer-by-blocking-the-androgen-receptor-and-inhibiting-cyp17a1
#19
REVIEW
Riikka Oksala, Anu Moilanen, Reetta Riikonen, Petteri Rummakko, Arja Karjalainen, Mikko Passiniemi, Gerd Wohlfahrt, Päivi Taavitsainen, Chira Malmström, Meri Ramela, Hanna-Maija Metsänkylä, Riikka Huhtaniemi, Pekka J Kallio, Mika Vj Mustonen
We report the discovery of a novel nonsteroidal dual-action compound, ODM-204, that holds promise for treating patients with castration-resistant prostate cancer (CRPC), an advanced form of prostate cancer characterised by high androgen receptor (AR) expression and persistent activation of the AR signaling axis by residual tissue androgens. For ODM-204, has a dual mechanism of action. The compound is anticipated to efficiently dampen androgenic stimuli in the body by inhibiting CYP17A1, the prerequisite enzyme for the formation of dihydrotestosterone (DHT) and testosterone (T), and by blocking AR with high affinity and specificity...
February 10, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29437985/comparing-the-characteristics-of-users-of-an-online-service-for-sti-self-sampling-with-clinic-service-users-a-cross-sectional-analysis
#20
Sharmani Barnard, Caroline Free, Ioannis Bakolis, Katy M E Turner, Katharine J Looker, Paula Baraitser
OBJECTIVES: Online services for self-sampling at home could improve access to STI testing; however, little is known about those using this new modality of care. This study describes the characteristics of users of online services and compares them with users of clinic services. METHODS: We conducted a cross-sectional analysis of routinely collected data on STI testing activity from online and clinic sexual health services in Lambeth and Southwark between 1January 2016 and 31March 2016...
February 7, 2018: Sexually Transmitted Infections
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