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https://www.readbyqxmd.com/read/29928881/mouse-model-of-chorea-acanthocytosis-exhibits-male-infertility-caused-by-impaired-sperm-motility-as-a-result-of-ultrastructural-morphological-abnormalities-in-the-mitochondrial-sheath-in-the-sperm-midpiece
#1
Omi Nagata, Masayuki Nakamura, Hitoshi Sakimoto, Yuka Urata, Natsuki Sasaki, Nari Shiokawa, Akira Sano
Chorea-acanthocytosis (ChAc) is an autosomal recessive hereditary disease characterized by neurodegeneration in the striatum and acanthocytosis caused by loss-of-function mutations in the Vacuolar Protein Sorting 13 Homolog A (VPS13A) gene, which encodes chorein. We previously produced a ChAc-model mouse with a homozygous deletion of exons 60-61 in Vps13a, which corresponded to the human disease mutation. We found that male ChAc-model mice exhibited complete infertility as a result of severely diminished sperm motility...
June 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29928866/hepatitis-b-virus-promotes-proliferation-and-metastasis-in-male-chinese-hepatocellular-carcinoma-patients-through-the-lef-1-mir-371a-5p-srcin1-pleiotrophin-slug-pathway
#2
Pei-Song Bai, Peng Hou, Ying Kong
Hepatocellular carcinoma (HCC) is a male-dominant cancer. Several factors may contribute to the gender difference. Recent investigations have reported that miRNAs are involved in sex-linked signaling pathways and play a critical role in the molecular pathogenesis of hepatitis B virus (HBV)-related HCC. Therefore, we speculated that some of these miRNAs might contribute to the gender differences observed in HBV-related HCC. Our results showed that miR-371a-5p was significantly upregulated in tumor tissue and serum from HCC patients and that the expression level of miR-371a-5p was related to HBV infection, sexuality, TNM stage, adjacent organ invasion and microvascular invasion...
June 18, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29928692/x-chromosome-protects-against-bladder-cancer-in-females-via-a-kdm6a-dependent-epigenetic-mechanism
#3
Satoshi Kaneko, Xue Li
Men are much more likely than women to develop bladder cancer (BCa), but the underlying cause of this gender disparity remains poorly defined. Using sex-reversed mice, we show that the sex chromosome complement is an independent cause and, moreover, amplifies the biasing effects of sex hormones. We also show that the X-linked lysine demethylase 6A ( KDM6A ) is a sexually dimorphic gene. Wild-type but not catalytically dead KDM6A confers sustained tumor suppressor activity in vitro. Knockout of mouse Kdm6a reduces expression of Cdkn1a and Perp , canonical gene targets of the tumor suppressor p53 ...
June 2018: Science Advances
https://www.readbyqxmd.com/read/29927957/perceived-peer-norms-health-risk-behaviors-and-clustering-of-risk-behaviors-among-palestinian-youth
#4
Peter Glick, Umaiyeh Khammash, Mohammed Shaheen, Ryan Brown, Prodyumna Goutam, Rita Karam, Sebastian Linnemayr, Salwa Massad
Relatively little is known about patterns of health risk behaviors among Middle Eastern youth, including how these behaviors are related to perceived peer norms. In a sample of approximately 2,500 15-24 year old Palestinian youth, perceived engagement of general peers in alcohol consumption, drug use and sexual activity was substantially greater than youths' own (self-reported) engagement in these activities, suggesting a tendency to overestimate the prevalence of risk-taking behavior among peers. Individual participation in a risk behavior strongly covaries with the perceived levels of both friends' and peers' engagement in that behavior (p = 0...
2018: PloS One
https://www.readbyqxmd.com/read/29927790/microglial-p2x4r-evoked-pain-hypersensitivity-is-sexually-dimorphic-in-rats
#5
Josiane C S Mapplebeck, Rebecca Dalgarno, YuShan Tu, Orla Moriarty, Simon Beggs, Charlie H T Kwok, Katherine Halievski, Sofia Assi, Jeffrey S Mogil, Tuan Trang, Michael W Salter
Microglia-neuron signalling in the spinal cord is a key mediator of mechanical allodynia caused by peripheral nerve injury. We recently reported sex differences in microglia in pain signalling in mice: spinal mechanisms underlying nerve injury-induced allodynia are microglial dependent in male but not female mice. Whether this sex difference in pain hypersensitivity mechanisms is conserved in other species is unknown. Here, we show that in rats, the spinal mechanisms of nerve injury-induced hypersensitivity in males differ from those in females, with microglial P2X4 receptors (P2X4Rs) being a key point of divergence...
April 30, 2018: Pain
https://www.readbyqxmd.com/read/29927003/immune-deployment-increases-larval-vulnerability-to-predators-and-inhibits-adult-life-history-traits-in-a-dragonfly
#6
Michael P Moore, Cassandra Lis, Ryan A Martin
While deploying immune defenses early in ontogeny can trade-off with the production and maintenance of other important traits across the entire life cycle, it remains largely unexplored how features of the environment shape the magnitude or presence of these lifetime costs. Greater predation risk during the juvenile stage may particularly influence such costs by 1) magnifying the survival costs that arise from any handicap of juvenile avoidance traits and/or 2) intensifying allocation trade-offs with important adult traits...
June 21, 2018: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29926261/hypersexuality-gender-and-sexual-orientation-a-large-scale-psychometric-survey-study
#7
Beáta Bőthe, Réka Bartók, István Tóth-Király, Rory C Reid, Mark D Griffiths, Zsolt Demetrovics, Gábor Orosz
Criteria for hypersexual disorder (HD) were proposed for consideration in the DSM-5 but ultimately excluded for a variety of reasons. Regardless, research continues to investigate hypersexual behavior (HB). The Hypersexual Behavior Inventory (HBI) is one of the most robust scales assessing HB, but further examination is needed to explore its psychometric properties among different groups. Therefore, the aim of the present study was to examine the generalizability of the HBI in a large, diverse, non-clinical sample (N = 18,034 participants; females = 6132; 34...
June 20, 2018: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29925936/does-underestimated-penile-size-impact-erectile-function-in-healthy-men
#8
Brunno Cf Sanches, Walker W Laranja, João Cc Alonso, Ronald F Rejowski, Fabiano A Simões, Leonardo O Reis
The aim of this study is to assess the impact of objective (stretched) and subjective penile size in the erectile function in a urological check-up program on a cross-sectional study including 689 men aged 35-70 years. IIEF-5 questionnaire, physical examination (penile length, prostate volume, blood pressure, body mass index-BMI), metabolic syndrome (MS), comorbidities, habits (sexual intercourse frequency, physical activity, alcohol, and tobacco use), level of education, serum glucose, total testosterone, estradiol, PSA, lipid profile, and self-perceptions (ejaculation time and subjective penile size) were examined in multivariate models using logistic and linear regressions...
June 21, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29925891/targeting-the-association-between-telomere-length-and-immuno-cellular-bioenergetics-in-female-patients-with-major-depressive-disorder
#9
Christina Boeck, Juan Salinas-Manrique, Enrico Calzia, Peter Radermacher, Christine A F von Arnim, Detlef E Dietrich, Iris-Tatjana Kolassa, Alexander Karabatsiakis
Major Depressive Disorder (MDD) has been associated with telomere dysfunction and alterations in mitochondrial activity, which seem to be co-regulated in human cells. To investigate this co-regulation in MDD, we assessed telomere length (TL) in peripheral blood mononuclear cells (PBMC) and selected immune cell subsets by quantitative fluorescence in situ hybridization and mitochondrial respiratory activity in PBMC by high-resolution respirometry in a study cohort of 18 MDD patients and 21 non-depressed controls...
June 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29925670/national-prevalence-estimates-of-chlamydia-and-gonorrhoea-in-the-netherlands
#10
Janneke C M Heijne, Ingrid V F van den Broek, Sylvia M Bruisten, Jan E A van Bergen, Hanneke de Graaf, Birgit H B van Benthem
OBJECTIVES: National prevalence estimates of Chlamydia trachomatis (chlamydia) and Neisseria gonorrhoeae (gonorrhoea) are important for providing insights in the occurrence and control of these STIs. The aim was to obtain national prevalence estimates for chlamydia and gonorrhoea and to investigate risk factors associated with infection. METHODS: Between November 2016 and January 2017, we performed a national population-based cross-sectional probability sample survey among men and women aged 18-34 years in the Netherlands...
June 20, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29925359/a-contextually-relevant-approach-to-assessing-health-risk-behavior-in-a-rural-sub-saharan-africa-setting-the-kilifi-health-risk-behavior-questionnaire
#11
Derrick Ssewanyana, Anneloes van Baar, Charles R Newton, Amina Abubakar
BACKGROUND: Health risk behavior (HRB) is of concern during adolescence. In sub-Saharan Africa, reliable, valid and culturally appropriate measures of HRB are urgently needed. This study aims at assembling and psychometrically evaluating a comprehensive questionnaire on HRB of adolescents in Kilifi County at the coast of Kenya. METHODS: The Kilifi Health Risk Behavior Questionnaire (KRIBE-Q) was assembled using items on HRB identified from a systematic review and by consulting 85 young people through 11 focus group discussions and in-depth interviews with 10 key informants like teachers and employees of organizations providing various services to young people in Kilifi County...
June 20, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29924994/sex-specific-features-of-microglia-from-adult-mice
#12
Alessandro Villa, Paolo Gelosa, Laura Castiglioni, Mauro Cimino, Nicoletta Rizzi, Giovanna Pepe, Federica Lolli, Elena Marcello, Luigi Sironi, Elisabetta Vegeto, Adriana Maggi
Sex has a role in the incidence and outcome of neurological illnesses, also influencing the response to treatments. Neuroinflammation is involved in the onset and progression of several neurological diseases, and the fact that estrogens have anti-inflammatory activity suggests that these hormones may be a determinant in the sex-dependent manifestation of brain pathologies. We describe significant differences in the transcriptome of adult male and female microglia, possibly originating from perinatal exposure to sex steroids...
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29923014/how-bothersome-double-j-ureteral-stents-are-after-semirigid-and-flexible-ureteroscopy-a-prospective-single-institution-observational-study
#13
Andrea Bosio, Eugenio Alessandria, Ettore Dalmasso, Dario Peretti, Simone Agosti, Alessandro Bisconti, Paolo Destefanis, Roberto Passera, Paolo Gontero
PURPOSE: To evaluate in details the actual extent of double-J stent-related symptoms after semirigid (URS) and flexible (RIRS) ureteroscopy using a validated questionnaire. METHODS: We asked to complete the Ureteric Stent Symptoms Questionnaire (USSQ) to all stone patients undergoing URS or RIRS with stent placement from 2010 to 2015. Stent-related symptoms' prevalence, severity, and impact on daily life were analyzed using descriptive statistics and five-order Likert scales...
June 19, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29922686/an-investigation-of-the-relationship-between-physical-fitness-self-concept-and-sexual-functioning
#14
Lia M Jiannine
BACKGROUND: Obesity and inactivity have led to an increasing number of individuals with sexual dysfunctions (43% of women; 31% of men). Small bouts of exercise can drastically improve sexual functioning. Thus, the present study is designed to examine the effects of physical fitness and self-concept on sexual functioning. MATERIALS AND METHODS: Fitness assessments and questionnaires were administered to 133 participants between the ages of 18 and 50 years. Physical fitness was assessed through body composition, cardiovascular endurance, muscular strength, and muscular endurance...
2018: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/29922107/stress-anxiety-depression-and-sexual-dysfunction-among-postmenopausal-women-in-shiraz-iran-2015
#15
Zahra Yazdanpanahi, Marzieh Nikkholgh, Marzieh Akbarzadeh, Saeedh Pourahmad
BACKGROUND: Menopause is associated with decreased sexual activity and a feeling of decreased attractiveness and sexual potency. This study tested the hypothesis that sexual health in postmenopausal women is not the same as nonmenopausal women with regard to symptoms of stress, anxiety, and depression. MATERIALS AND METHODS: This cross-sectional study was conducted in 12 health centers in Shiraz between April and September 2015; 310 postmenopausal women included by convenient sampling...
May 2018: Journal of Family & Community Medicine
https://www.readbyqxmd.com/read/29921893/pharmacological-interventions-for-premature-ejaculation-a-mixed-treatment-comparison-network-meta-analysis-of-randomized-clinical-trials
#16
Kannan Sridharan, Gowri Sivaramakrishnan, Reginald P Sequeira, Khalid Aj Al-Khaja
Premature ejaculation (PE) is the most common sexual dysfunction in men. The present study is a network meta-analysis of drugs used for treating PE. Electronic databases were searched for randomized controlled trials comparing medical interventions with either placebo or with other active drugs in patients with PE. Inverse variance heterogeneity model was used for mixed-treatment comparisons. Intravaginal ejaculatory latency time (IELT) and adverse events were the main outcome measures. A total of 44 studies were included in the meta-analysis...
June 20, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29920952/high-risk-sexual-behaviour-in-young-people-with-mental-health-disorders
#17
Asiel Yair Adan Sanchez, Elizabeth McMillan, Amit Bhaduri, Nancy Pehlivan, Katherine Monson, Paul Badcock, Katherine Thompson, Eoin Killackey, Andrew Chanen, Brian O'Donoghue
AIM: This study aimed to determine the prevalence of high-risk sexual behaviours, sequelae and associated factors in young people attending a youth mental health service. METHODS: The study design was a cross-sectional survey of 103 young people aged between 15-25 years carried out across four specialist mental health clinics. A questionnaire on the sexual health of secondary level students was adapted for this study. Mental health symptomatology was assessed through the Brief Psychiatric Rating Scale (BPRS)...
June 19, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29920429/changes-in-sexuality-during-ulipristal-acetate-treatment-in-women-with-symptomatic-uterine-fibroids
#18
Benjamin Tuschy, Mirja Gabbert, Christel Weiss, Amadeus Hornemann, Anne Wuhrer, Marc Sütterlin, Sebastian Berlit
OBJECTIVE: To evaluate changes in sexuality in women treated with Ulipristal acetate (UPA) due to symptomatic uterine fibroids. STUDY DESIGN: A total of 102 women with symptomatic uterine fibroids undergoing conservative therapy with UPA were enrolled in this observational study. Sexuality was evaluated before and after a three month UPA treatment using the Female Sexual Functioning Index (FSFI) as well as the Sexual Activity Questionnaire (SAQ). Before treatment was initiated, participants additionally filled in a standardised questionnaire addressing the expected changes in sexuality due to UPA...
June 16, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29916947/factors-associated-with-developing-vaginal-dryness-symptoms-in-women-transitioning-through-menopause-a-longitudinal-study
#19
L Elaine Waetjen, Sybil L Crawford, Po-Yin Chang, Barbara D Reed, Rachel Hess, Nancy E Avis, Sioban D Harlow, Gail A Greendale, Sheila A Dugan, Ellen B Gold
OBJECTIVE: To evaluate factors associated with incident self-reported vaginal dryness and the consequences of this symptom across the menopausal transition in a multiracial/ethnic cohort of community-dwelling women. METHODS: We analyzed questionnaire and biomarker data from baseline and 13 approximately annual visits over 17 years (1996-2013) from 2,435 participants in the Study of Women's Health Across the Nation, a prospective cohort study. We used discrete-time Cox proportional-hazards regression to identify predictors of incident vaginal dryness and to evaluate vaginal dryness as a predictor of pain during intercourse and changes in sexual intercourse frequency...
June 18, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29916355/extragenital-gonorrhoea-in-men-who-have-sex-with-men-a-retrospective-study-in-a-sti-clinic-in-lisbon-portugal
#20
Margarida Moura Valejo Coelho, Eugénia Matos-Pires, Vasco Serrão, Ana Rodrigues, Cândida Fernandes
INTRODUCTION: Recent studies worldwide reveal a significant prevalence of extragenital infections by Neisseria gonorrhoeae among men who have sex with men. We aimed to analyse the frequency and characteristics of extragenital gonococcal infections diagnosed in men who have sex with men in a walk-in Sexually Transmitted Infection clinic in Lisbon, Portugal. MATERIAL AND METHODS: We conducted a cross-sectional, retrospective study of the anorectal and/or oropharyngeal Neisseria gonorrhoeae infections in men who have sex with men, diagnosed in our Sexually Transmitted Infection clinic between January 2014 and December 2016...
May 30, 2018: Acta Médica Portuguesa
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