keyword
MENU ▼
Read by QxMD icon Read
search

marine based compounds

keyword
https://www.readbyqxmd.com/read/28816107/fishing-anti-inflammatories-from-known-drugs-in-silico-repurposing-design-synthesis-and-biological-evaluation-of-bisacodyl-analogues
#1
Maité Sylla-Iyarreta Veitía, Dany Siverio Mota, Vanessa Lerari, Marta Marín, Rosa M Giner, Liliana Vicet Muro, Yankier Rivero Guerra, Françoise Dumas, Clotilde Ferroud, Peter A M de Witte, Alexander D Crawford, Vicente J Arán, Yovani Marrero Ponce
Herein is described in silico repositioning, design, synthesis, biological evaluation and structure-activity relationship (SAR) of an original class of anti-inflammatory agents based on a polyaromatic pharmacophore structurally related to bisacodyl (BSL) drug used in therapeutic as laxative. We describe the potential of TOMOCOMD-CARDD methods to find out new anti-inflammatory drug-like agents from a diverse series of compounds using the total and local atom based bilinear indices as molecular descriptors. The models obtained were validated by biological studies, identifying BSL as the first anti-inflammatory lead-like using in silico repurposing from commercially available drugs...
August 17, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28815284/analysis-of-lipophilic-marine-biotoxins-by-liquid-chromatography-coupled-with-high-resolution-mass-spectrometry-in-seawater-from-the-catalan-coast
#2
Cristina Bosch-Orea, Josep Sanchís, Marinella Farré, Damià Barceló
Marine biotoxins regularly occur along the coast, with several consequences for the environment as well as the food industry. Monitoring of these compounds in seawater is required to assure the safety of marine resources for human consumption, providing a means for forecasting shellfish contamination events. In this study, an analytical method was developed for the detection of ten lipophilic marine biotoxins in seawater: azaspiracids 1, 2, 3, 4 and 5, classified as azaspiracid shellfish poisoning toxins, and pectenotoxin 2, okadaic acid and the related dinophysistoxin 1, yessotoxin and homoyessotoxin, classified as diarrheic shellfish poisoning toxins...
August 16, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28808657/nanoparticulate-tubular-immunostimulating-complexes-novel-formulation-of-effective-adjuvants-and-antigen-delivery-systems
#3
REVIEW
Nina Sanina, Natalia Chopenko, Andrey Mazeika, Eduard Kostetsky
New generation vaccines, based on isolated antigens, are safer than traditional ones, comprising the whole pathogen. However, major part of purified antigens has weak immunogenicity. Therefore, elaboration of new adjuvants, more effective and safe, is an urgent problem of vaccinology. Tubular immunostimulating complexes (TI-complexes) are a new type of nanoparticulate antigen delivery systems with adjuvant activity. TI-complexes consist of cholesterol and compounds isolated from marine hydrobionts: cucumarioside A2-2 (CDA) from Cucumaria japonica and monogalactosyldiacylglycerol (MGDG) from marine algae or seagrass...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28805711/a-dereplication-and-bioguided-discovery-approach-to-reveal-new-compounds-from-a-marine-derived-fungus-stilbella-fimetaria
#4
Sara Kildgaard, Karolina Subko, Emma Phillips, Violaine Goidts, Mercedes de la Cruz, Caridad Díaz, Charlotte H Gotfredsen, Birgitte Andersen, Jens C Frisvad, Kristian F Nielsen, Thomas O Larsen
A marine-derived Stilbella fimetaria fungal strain was screened for new bioactive compounds based on two different approaches: (i) bio-guided approach using cytotoxicity and antimicrobial bioassays; and (ii) dereplication based approach using liquid chromatography with both diode array detection and high resolution mass spectrometry. This led to the discovery of several bioactive compound families with different biosynthetic origins, including pimarane-type diterpenoids and hybrid polyketide-non ribosomal peptide derived compounds...
August 13, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28803761/an-in-silico-perspective-on-the-toxicodynamic-of-tetrodotoxin-and-analogues-a-tool-for-supporting-the-hazard-identification
#5
Luca Dellafiora, Gianni Galaverna, Chiara Dall'Asta
Tetrodotoxin (TTX) is a potent neurotoxin naturally found in terrestrial and marine animals targeting the voltage-gated sodium channels. Historically, TTX has raised food safety concerns mainly in the Asian countries due to the consumption of the typical pufferfish-derived delicacy fugu. However, the diffusion of TTX is getting wider today, reasonably threating in a close future a broader number of consumers than before. The understanding of TTX group toxicity is still incomplete as most of the analogues and metabolites found together with TTX are largely understudied...
August 10, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28789716/in-vitro-antileishmanial-activity-and-iron-superoxide-dismutase-inhibition-of-arylamine-mannich-base-derivatives
#6
Alvaro Martin-Montes, Mery Santivañez-Veliz, Elsa Moreno-Viguri, Rubén Martín-Escolano, Carmen Jiménez-Montes, Catalina Lopez-Gonzalez, Clotilde Marín, Carmen Sanmartín, Ramón Gutiérrez Sánchez, Manuel Sánchez-Moreno, Silvia Pérez-Silanes
Leishmaniasis is one of the world's most neglected diseases, and it has a worldwide prevalence of 12 million. There are no effective human vaccines for its prevention, and treatment is hampered by outdated drugs. Therefore, research aiming at the development of new therapeutic tools to fight leishmaniasis remains a crucial goal today. With this purpose in mind, we present 20 arylaminoketone derivatives with a very interesting in vitro and in vivo efficacy against Trypanosoma cruzi that have now been studied against promastigote and amastigote forms of Leishmania infantum, Leishmania donovani and Leishmania braziliensis strains...
August 9, 2017: Parasitology
https://www.readbyqxmd.com/read/28783126/the-neuroprotective-marine-compound-psammaplysene-a-binds-the-rna-binding-protein-hnrnpk
#7
Marco Boccitto, Nayoung Lee, Satoshi Sakamoto, Lynn A Spruce, Hiroshi Handa, Jon Clardy, Steven H Seeholzer, Robert G Kalb
In previous work, we characterized the strong neuroprotective properties of the marine compound Psammaplysene A (PA) in in vitro and in vivo models of neurodegeneration. Based on its strong neuroprotective activity, the current work attempts to identify the physical target of PA to gain mechanistic insight into its molecular action. Two distinct methods, used in parallel, to purify protein-binding partners of PA led to the identification of HNRNPK as a direct target of PA. Based on surface plasmon resonance, we find that the binding of PA to HNRNPK is RNA-dependent...
August 7, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28772689/new-bio-composites-based-on-polyhydroxyalkanoates-and-posidonia-oceanica-fibres-for-applications-in-a-marine-environment
#8
Maurizia Seggiani, Patrizia Cinelli, Norma Mallegni, Elena Balestri, Monica Puccini, Sandra Vitolo, Claudio Lardicci, Andrea Lazzeri
Bio-composites based on polyhydroxyalkanoates (PHAs) and fibres of Posidonia oceanica (PO) were investigated to assess their processability by extrusion, mechanical properties, and potential biodegradability in a natural marine environment. PHAs were successfully compounded with PO fibres up to 20 wt % while, at 30 wt % of fibres, the addition of 10 wt % of polyethylene glycol (PEG 400) was necessary to improve their processability. Thermal, rheological, mechanical, and morphological characterizations of the developed composites were conducted and the degradation of composite films in a natural marine habitat was evaluated in a mesocosm by weight loss measure during an incubation period of six months...
March 23, 2017: Materials
https://www.readbyqxmd.com/read/28767266/paul-langerhans-a-prilgrim-traveling-from-functional-histology-to-marine-biology
#9
REVIEW
Marius Raica, Anca Maria Cimpean
The nineteenth century was the time of a real revolution in science and medicine. A lot of seminal discoveries in medicine and biology were done in this time, and many of them were coincident with the introduction of the compound microscope by Hermann van Deijl and the standard histological technique by Paul Ehrlich. The main tissue types and individual cells were characterized and originally classified more than hundred years ago, although less attention was paid to their basic functions. This was mainly due to the modality of tissue specimen processing that allowed particularly detailed descriptive studies...
June 2017: Acta Medico-historica Adriatica: AMHA
https://www.readbyqxmd.com/read/28758223/metabonomics-profiling-of-marinated-meat-in-soy-sauce-during-processing
#10
Yang Yang, Yangfang Ye, Daodong Pan, Yangying Sun, Ying Wang, Jinxuan Cao
BACKGROUND: Marinated meat in soy sauce is one of the most popular traditional cured meat products in China. Its taste quality is directly related to primary and secondary metabolites. Herein, the change of metabolite composition of marinated meat in soy sauce during processing was systematically characterized using (1) H NMR and multivariate data analysis. RESULTS: The marinated meat in soy sauce metabonome was dominated by 26 metabolites, including amino acids, sugars, organic acids, nucleic aides and their derivatives...
July 31, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28755592/the-toxicity-of-molybdate-to-freshwater-and-marine-organisms-iii-generating-additional-chronic-toxicity-data-for-the-refinement-of-safe-environmental-exposure-concentrations-in-the-us-and-europe
#11
D G Heijerick, S Carey
The freshwater and marine long-term ecotoxicity datasets used in the European REACH registration dossiers for molybdenum and molybdenum compounds resulted in the derivation of a HC5,50%,freshwater (38.2mgMo/L) and HC5,50%,marine (5.70mgMo/L) by means of the statistical extrapolation method. Both datasets, however, did not meet the US-EPA information requirements for deriving Final Chronic Values (FCV) that were based on chronic data. US-EPA compliance was achieved by generating chronic no-effect data for the freshwater benthic amphipod Hyalella azteca and the marine inland silverside fish Menidia beryllina, using sodium molybdate dihydrate as test substance...
July 26, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28752885/effects-of-preparation-on-nutrient-and-environmental-contaminant-levels-in-arctic-beluga-whale-delphinapterus-leucas-traditional-foods
#12
Matthew J Binnington, Ying D Lei, Lucky Pokiak, James Pokiak, Sonja K Ostertag, Lisa L Loseto, Hing M Chan, Leo W Y Yeung, Haiyong Huang, Frank Wania
For Canadian Arctic indigenous populations, marine mammal (MM) traditional foods (TFs) represent sources of both important nutrients and hazardous environmental contaminants. Food preparation is known to impact the nutrient and environmental contaminant content of processed items, yet the impacts of preparation on indigenous Arctic MM TFs remain poorly characterized. In order to determine how the various processes involved in preparing beluga blubber TFs affect their levels of nutrients and environmental contaminants, we collected blubber samples from 2 male beluga whales, aged 24 and 37 years, captured during the 2014 summer hunting season in Tuktoyaktuk, Northwest Territories, and processed them according to local TF preparation methods...
August 16, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28751049/cyanobacteria-as-sources-of-marine-bioactive-compounds-molecular-specific-detection-based-on-%C3%AE-9-desaturase-gene
#13
Faten Ben Amor, Mohamed Barkallah, Fatma Eleuch, Nesrine Karkouch, Mouna Dammak, Bruno Baréa, Pierre Villeneuve, Slim Abdelkafi, Imen Fendri
The blue-green microalga, Arthrospira sp., isolated from the sea of Kssour Essef in Mahdia, (Tunisia), was purified then identified both morphologically and genetically via 16S rDNA specific primers. The amplified 16S rDNA of the isolated cyanobacterium were sequenced. Following physicochemical analysis, the prokaryotic microalgae tested represented a competitive source of pigments and showed a considerable rate in protein which was confirmed by FTIR measurement. The lipid content was quantified by the gravimetric method and the intracellular lipid bodies were detected with the Nile red staining...
July 24, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28733703/induction-of-accelerated-senescence-by-the-microtubule-stabilizing-agent-peloruside-a
#14
Ariane Chan, Connie Gilfillan, Nikki Templeton, Ian Paterson, Peter T Northcote, John H Miller
Chemotherapeutic agents can induce accelerated senescence in tumor cells, an irreversible state of cell cycle arrest. Paclitaxel, a microtubule-stabilizing agent used to treat solid tumors of the breast, ovary, and lung and discodermolide, another stabilizing agent from a marine sponge, induce senescence in cultured cancer cells. The aim of this study was to determine if the microtubule-stabilizing agent peloruside A, a polyketide natural product from a marine sponge, can induce accelerated senescence in a breast cancer cell line MCF7...
July 22, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28729856/biological-significance-of-marine-actinobacteria-of-east-coast-of-andhra-pradesh-india
#15
Alapati Kavitha, Handanahal S Savithri
An attempt was made to identify actinobacterial strains present in the marine soil of East Coast regions viz., Chirala, Bapatla, and Peddaganjam, Andhra Pradesh; Kanyakumari, Tamil Nadu and Goa, Goa along with the study of their antimicrobial potential. Eight out of 73 actinobacterial strains isolated from these regions showed strong antimicrobial activity against Gram positive bacteria, Gram negative bacteria, and Candida albicans. Molecular identification (16S rRNA analysis) of the eight strains revealed that they belong to Dietzia sp...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28720331/a-novel-antihypertension-agent-sargachromenol-d-from-marine-brown-algae-sargassum-siliquastrum-exerts-dual-action-as-an-l-type-ca-2-channel-blocker-and-endothelin-a-b2-receptor-antagonist
#16
Byong-Gon Park, Woon-Seob Shin, Sangtae Oh, Gab-Man Park, Nam Ik Kim, Seokjoon Lee
We isolated the novel vasoactive marine natural products, (5E,10E)-14-hydroxy-2,6,10-trimethylpentadeca-5,10-dien-4-one (4) and sargachromenol D (5), from Sargassum siliquastrum collected from the coast of the East Sea in South Korea by using activity-guided HPLC purification. The compounds effectively dilated depolarization (50mMK(+))-induced basilar artery contraction with EC50 values of 3.52±0.42 and 1.62±0.63μM, respectively, but only sargachromenol D (5) showed a vasodilatory effect on endothelin-1 (ET-1)-induced basilar artery contraction (EC50=9...
July 6, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28717220/imaging-mass-spectrometry-and-ms-ms-molecular-networking-reveals-chemical-interactions-among-cuticular-bacteria-and-pathogenic-fungi-associated-with-fungus-growing-ants
#17
Cristopher A Boya P, Hermógenes Fernández-Marín, Luis C Mejía, Carmenza Spadafora, Pieter C Dorrestein, Marcelino Gutiérrez
The fungus-growing ant-microbe symbiosis is an ideal system to study chemistry-based microbial interactions due to the wealth of microbial interactions described, and the lack of information on the molecules involved therein. In this study, we employed a combination of MALDI imaging mass spectrometry (MALDI-IMS) and MS/MS molecular networking to study chemistry-based microbial interactions in this system. MALDI IMS was used to visualize the distribution of antimicrobials at the inhibition zone between bacteria associated to the ant Acromyrmex echinatior and the fungal pathogen Escovopsis sp...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28713339/concurrent-methane-production-and-oxidation-in-surface-sediment-from-aarhus-bay-denmark
#18
Ke-Qing Xiao, Felix Beulig, Kasper U Kjeldsen, Bo B Jørgensen, Nils Risgaard-Petersen
Marine surface sediments, which are replete with sulfate, are typically considered to be devoid of endogenous methanogenesis. Yet, methanogenic archaea are present in those sediments, suggesting a potential for methanogenesis. We used an isotope dilution method based on sediment bag incubation and spiking with (13)C-CH4 to quantify CH4 turnover rates in sediment from Aarhus Bay, Denmark. In two independent experiments, highest CH4 production and oxidation rates (>200 pmol cm(-3) d(-1)) were found in the top 0-2 cm, below which rates dropped below 100 pmol cm(-3) d(-1) in all other segments down to 16 cm...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28711841/free-amino-acids-in-the-arctic-snow-and-ice-core-samples-potential-markers-for-paleoclimatic-studies
#19
Elena Barbaro, Andrea Spolaor, Ornela Karroca, Ki-Tae Park, Tõnu Martma, Elisabeth Isaksson, Jack Kohler, Jean Charles Gallet, Mats P Bjorkman, David Cappelletti, Gunnar Spreen, Roberta Zangrando, Carlo Barbante, Andrea Gambaro
The role of oceanic primary production on climate variability has long been debated. Defining changes in past oceanic primary production can help understanding of the important role that marine algae have in climate variability. In ice core research methanesulfonic acid is the chemical marker commonly used for assessing changes in past primary production. However, other organic compounds such as amino acids, can be produced and emitted into the atmosphere during a phytoplankton bloom. These species can be transported and deposited onto the ice cap in polar regions...
July 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28703765/anti-biofilm-effect-of-biodegradable-coatings-based-on-hemibastadin-derivative-in-marine-environment
#20
Tiffany Le Norcy, Hendrik Niemann, Peter Proksch, Isabelle Linossier, Karine Vallée-Réhel, Claire Hellio, Fabienne Faÿ
Dibromohemibastadin-1 (DBHB) is an already known potent inhibitor of blue mussel phenoloxidase (which is a key enzyme involved in bioadhesion). Within this study, the potentiality of DBHB against microfouling has been investigated. The activity of DBHB was evaluated on key strains of bacteria and microalgae involved in marine biofilm formation and bioassays assessing impact on growth, adhesion and biofilm formation were used. To assess the efficiency of DBHB when included in a matrix, DBHB varnish was prepared and the anti-microfouling activity of coatings was assessed...
July 13, 2017: International Journal of Molecular Sciences
keyword
keyword
118795
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"