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marine based compounds

Qi Zhang, Rungravee Kanjanasuntree, Jong-Hwa Kim, Jung-Hoon Yoon, Ampaitip Sukhoom, Duangporn Kantachote, Wonyong Kim
A Gram-stain-negative, strictly aerobic, motile by one single flagellum, dark-orange pigmented and rod-shaped bacterial strain, designated CAU 1457T , was isolated from marine sediment in the Republic of Korea and its taxonomic position was investigated by using a polyphasic approach. The isolate grew optimally at 30 °C, at pH 6.0 and in the presence of 2 % (w/v) NaCl. Based on 16S rRNA gene sequences similarity, strain CAU 1457T belonged to the genus Sphingomicrobium and was related most closely to Sphingomicrobium astaxanthinifaciens JCM 18551T (98...
June 21, 2018: International Journal of Systematic and Evolutionary Microbiology
Durairajan Rubini, Sanaulla Farisa Banu, Prakash Nisha, Ramar Murugan, Subbiah Thamotharan, María Judith Percino, Prabha Subramani, Paramasivam Nithyanand
In the current study we have evaluated the antibiofilm and antivirulent properties of unexplored essential oils (EOs) obtained from Pogostemon heyneanus and Cinnamomum tamala against Methicillin Resistant Staphylococcus aureus (MRSA) strains. The EOs from both the aromatic plants was screened for their ability to prevent biofilm formation and to disrupt preformed biofilms. The efficacy of both the EOs to disrupt the preformed biofilms of various MRSA strains was determined by Confocal Laser Scanning Microscopy (CLSM) and Scanning Electron Microscopy (SEM)...
June 16, 2018: Microbial Pathogenesis
Amr El-Demerdash, Mohamed A Tammam, Atanas G Atanasov, John N A Hooper, Ali Al-Mourabit, Anake Kijjoa
Over the past seven decades, particularly since the discovery of the first marine-derived nucleosides, spongothymidine and spongouridine, from the Caribbean sponge Cryptotethya crypta in the early 1950s, marine natural products have emerged as unique, renewable and yet under-investigated pools for discovery of new drug leads with distinct structural features, and myriad interesting biological activities. Marine sponges are the most primitive and simplest multicellular animals, with approximately 8900 known described species, although more than 15,000 species are thought to exist worldwide today...
June 18, 2018: Marine Drugs
Mahasweta Saha, Franz Goecke, Punyasloke Bhadury
Marine biofouling is a paramount phenomenon in the marine environment and causes serious problems to maritime industries worldwide. Marine algae are known to produce a wide variety of chemical compounds with antibacterial, antifungal, antialgal, and anti-macrofouling properties, inhibiting the settlement and growth of other marine fouling organisms. Significant investigations and progress have been made in this field in the last two decades and several antifouling extracts and compounds have been isolated from micro- and macroalgae...
2018: Journal of Applied Phycology
Bo-Mi Kim, Manoharan Saravanan, Do-Hee Lee, Jung-Hoon Kang, Moonkoo Kim, Jee-Hyun Jung, Jae-Sung Rhee
Tributyltin (TBT) is as an antifouling organotin compound used in boat paints. Although organotin-based antifouling agents have been banned on a global scale, the mode of action of TBT has been studied in numerous aquatic species because of its toxicity, persistence, bioaccumulation potential, and endocrine-disrupting characteristics. In this study, we conducted 96-h acute toxicity tests wherein we exposed juvenile and adult marine mysids to waterborne TBT. Over 4 weeks of exposure, mortality was dose-dependently increased in juveniles and adult mysids...
June 7, 2018: Marine Environmental Research
Rubén Martín-Escolano, Elsa Moreno-Viguri, Mery Jhenny Santiváñez Veliz, Álvaro Martín-Montes, Encarnación Medina-Carmona, Rocío Paucar, Clotilde Marín, Amaya Azqueta, Nuria Cirauqui, Angel Luis Pey, Silvia Pérez-Silanes, Manuel Sánchez-Moreno
Chagas Disease is a potentially life-threatening and neglected tropical disease caused by Trypanosoma cruzi. One of the most important challenges related to Chagas disease is the search for new, safe, effective and affordable drugs since the current therapeutic arsenal is inadequate and insufficient. Here, we report a simple and cost-effective synthesis and the biological evaluation of the second generation of Mannich base-type derivatives. Compounds 7, 9 and 10 showed improved in vitro efficiency and lower toxicity than benznidazole, in addition to no genotoxicity; thus, they were applied in in vivo assays to assess their activity in both acute and chronic phases of the disease...
June 8, 2018: Journal of Medicinal Chemistry
Vivek K Bajpai, Shruti Shukla, Sung-Min Kang, Seung Kyu Hwang, Xinjie Song, Yun Suk Huh, Young-Kyu Han
Current trends in the application of nanomaterials are emerging in the nano-biotechnological sector for development of medicines. Cyanobacteria (blue-green algae) are photosynthetic prokaryotes that have applications to human health and numerous biological activities as dietary supplements. Cyanobacteria produce biologically active and chemically diverse compounds such as cyclic peptides, lipopeptides, fatty acid amides, alkaloids, and saccharides. More than 50% of marine cyanobacteria are potentially exploitable for the extraction of bioactive substances, which are effective in killing cancer cells by inducing apoptotic death...
May 23, 2018: Marine Drugs
Mohamed Saleh Abdelfattah, Mohammed Ismail Youssef Elmallah, Ahmed Hassan Ibrahim Faraag, Ali Mohamed Salah Hebishy, Neama Hassan Ali
Several actinomycetes strains were isolated from different marine sponges collected from the Red Sea shore in Egypt. The efficiency of their crude extracts to inhibit histone deacetylase (HDAC) enzyme was investigated in the nuclear extract of Hela cell line. The crude extract corresponding to Streptomyces sp. SP9 isolated from the marine sponge Pseudoceratina arabica showed a promising HDAC inhibitory activity with 64 and 81% at 50 and 100 µg/ml, respectively. The strain was identified as Streptomyces sp...
June 2018: 3 Biotech
Sharareh Sharifi, Pargol Ghavam Mostafavi, Ali Mashinchian Moradi, Mohammad Hadi Givianrad, Hassan Niknejad
Marine Soft corals have frequently been studied in recent years because of their specific chemical compounds in tissue engineering and regenerative medicine. The aim of this study was to investigate anti-cancer property of extracted compound from Virgularia gustaviana and their effect on inducing of apoptosis. The extraction process was carried out with ethyl acetate for 5 days and the extract was separated by silica-gel column chromatography. The column was washed with n-hexane-ethyl acetate solvent at ratio of 10:0 to 0:10...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Letizia Monico, Annalisa Chieli, Steven De Meyer, Marine Cotte, Wout de Nolf, Gerald Falkenberg, Koen Janssens, Aldo Romani, Costanza Miliani
Cadmium yellows (CdYs) refer to a family of cadmium sulfide pigments which have been widely used by artists since the late 19th c. Despite being considered stable, they are suffering from discoloration in iconic paintings, such as Joy of Life by Matisse, Flowers in a blue vase by Van Gogh and the Scream by Munch, most likely due to the formation of CdSO₄·nH₂O. Questions about what the factors driving the CdYs degradation are and how they affect the overall process are still open. Here, we study a series of oil mock-up paints made of CdYs of different stoichiometry (CdS/Cd₀...
June 6, 2018: Chemistry: a European Journal
Marine Breitwieser, Evelyne Vigneau, Amélia Viricel, Vanessa Becquet, Camille Lacroix, Marina Erb, Valérie Huet, Carine Churlaud, Stéphane Le Floch, Benoit Guillot, Marianne Graber, Hélène Thomas
Increasing activity along the French Atlantic coast has led to chronic pollution with, in particular, mixtures of contaminants such as hydrocarbons, phytosanitary products, PCBs and heavy metals. Based on previous research, pollution biomarkers were used in this study as they can indicate health status when monitoring the impact of pollutants on coastal species such as the marine bivalve Mimachlamys varia. Mollusc bivalves were sampled in March 2016, in open and semi-open areas (a harbour zone), from thirteen sites which differed in terms of their level of pollution, and were located along the Atlantic coast from Brittany down to the Nouvelle-Aquitaine region...
June 2, 2018: Science of the Total Environment
Maushmi S Kumar, Kaveri M Adki
Cancer is world's second largest alarming disease, which involves abnormal cell growth and have potential to spread to other parts of the body. Most of the available anticancer drugs are designed to act on specific targets by altering the activity of involved transporters and genes. As cancer cells exhibit complex cellular machinery, the regeneration of cancer tissues and chemo resistance towards the therapy has been the main obstacle in cancer treatment. This fact encourages the researchers to explore the multitargeted use of existing medicines to overcome the shortcomings of chemotherapy for alternative and safer treatment strategies...
May 30, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Larissa Buedenbender, Luke P Robertson, Leonardo Lucantoni, Vicky M Avery, D İpek Kurtböke, Anthony R Carroll
Chemical investigations on the fermentation extract obtained from an ascidian-derived Streptomyces sp. (USC-16018) yielded a new ansamycin polyketide, herbimycin G ( 1 ), as well as a known macrocyclic polyketide, elaiophylin ( 2 ), and four known diketopiperazines ( 3 ⁻ 6 ). The structures of the compounds were elucidated based on 1D/2D NMR and MS data. The absolute configuration of 1 was established by comparison of experimental and predicted electronic circular dichroism (ECD) data. Antiplasmodial activities were tested for the natural products against chloroquine sensitive (3D7) and chloroquine resistant (Dd2) Plasmodium falciparum strains; the two polyketides ( 1 ⁻ 2 ) demonstrated an inhibition of >75% against both parasite strains and while 2 was highly cytotoxic, herbimycin G ( 1 ) showed no cytotoxicity and good predicted water solubility...
May 30, 2018: Marine Drugs
Tara L Peters, Joseph Tillotson, Alison M Yeomans, Sarah Wilmore, Elizabeth Lemm, Carlos Jiménez-Romero, Luis A Amador, Lingxiao Li, Amit Dipak Amin, Praechompoo Pongtornpipat, Christopher J Zerio, Andrew J Ambrose, Gillian Paine-Murrieta, Patricia Greninger, Francisco Vega, Cyril H Benes, Graham Packham, Abimael D Rodriguez, Eli Chapman, Jonathan H Schatz
PURPOSE: The DEAD-box RNA helicase eIF4A1 carries out the key enzymatic step of cap-dependent translation initiation and is a well-established target for cancer therapy, but no drug against it has entered evaluation in patients. We identified and characterized a natural compound with broad antitumor activities that emerged from the first target-based screen to identify novel eIF4A1 inhibitors. EXPERIMENTAL DESIGN: We tested potency and specificity of the marine compound elatol vs...
May 29, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Christopher C Thornburg, John R Britt, Jason R Evans, Rhone K Akee, James A Whitt, Spencer K Trinh, Matthew J Harris, Jerell R Thompson, Teresa L Ewing, Suzanne M Shipley, Paul G Grothaus, David J Newman, Tanja Grkovic, Barry R O'Keefe
The US National Cancer Institute's (NCI) Natural Product Repository is one of the world's largest, most diverse collections of natural products containing over 230,000 unique extracts derived from plant, marine and microbial organisms that have been collected from biodiverse regions throughout the world. Importantly, this national resource is available to the research community for the screening of extracts and the isolation of bioactive natural products. However, despite the success of natural products in drug discovery, compatibility issues that make extracts challenging for liquid handling systems, extended timelines that complicate natural product-based drug discovery efforts and the presence of pan-assay interfering compounds have reduced enthusiasm for the high-throughput screening (HTS) of crude natural product extract libraries in targeted assay systems...
May 29, 2018: ACS Chemical Biology
Jesús Marín-Sáez, Roberto Romero-González, Antonia Garrido Frenich, Francisco Javier Egea-González
Homeopathic products are still a controversial issue in modern medicine, understood as complementary or alternative medicine (CAM). In this particular case, homeopathic products prepared from Atropa Belladonna extracts may present specific problems due to the effects derived from its components. This article applies a simple, rapid and reliable method to the analysis of different homeopathic products obtained from Atropa Belladonna; drugs containing high concentration of plant extracts; and Atropa Belladonna seeds...
May 28, 2018: Drug Testing and Analysis
Jun Shang, Ben Hu, Junmei Wang, Feng Zhu, Yu Kang, Dan Li, Huiyong Sun, De-Xin Kong, Tingjun Hou
This is a new golden age for the drug discovery based on natural products derived from both marine and terrestrial sources. Herein, a straightforward but important question is what are the major structural differences between marine natural products (MNPs) and terrestrial natural products (TNPs). To answer this question, we analyzed the important physicochemical properties, structural features and drug-likeness of the two types of natural products and discussed their differences from the perceptive of evolution...
May 24, 2018: Journal of Chemical Information and Modeling
Zhichao Zhou, Jie Pan, Fengping Wang, Ji-Dong Gu, Meng Li
Bathyarchaeota, formerly known as the Miscellaneous Crenarchaeotal Group, is a phylum of global generalists that are widespread in anoxic sediments, which host relatively high abundant archaeal communities. Until now, 25 subgroups have been identified in the Bathyarchaeota. The distinct bathyarchaeotal subgroups diverged to adapt to the marine and freshwater environments. Based on the physiological and genomic evidence, acetyl-CoA centralized heterotrophic pathways of energy conservation have been proposed to function in Bathyarchaeota; these microbes are able to anaerobically utilize (i) detrital proteins, (ii) polymeric carbohydrates, (iii) fatty acids/aromatic compounds, (iv) methane (or short chain alkane) and methylated compounds, (v) and/or potentially other organic matter...
May 21, 2018: FEMS Microbiology Reviews
Xiaoping Song, Ying Xiong, Xin Qi, Wei Tang, Jiajia Dai, Qianqun Gu, Jing Li
Over the past decades, a number of novel compounds, which are produced in the marine environment, have been found to exhibit the anticancer effects. This review focuses on molecular targets of marine-derived anticancer candidates in clinical and preclinical studies. They are kinases, transcription factors, histone deacetylase, the ubiquitin-proteasome system, and so on. Specific emphasis of this review paper is to provide information on the optimization of new target compounds for future research and development of anticancer drugs, based on the identification of structures of these target molecules and parallel compounds...
May 22, 2018: Marine Drugs
Anamaria Balić, Zrinka Bukvić Mokos, Branka Marinović, Daniela Ledić Drvar
Dear Editor, Pitted keratolysis (PK), also known as keratosis plantaris sulcatum, is a non-inflammatory, bacterial, superficial cutaneous infection, characterized by many discrete superficial crateriform ''pits'' and erosions in the thickly keratinized skin of the weight-bearing regions of the soles of the feet (1). The disease often goes unnoticed by the patient, but when it is noticed it is because of the unbearable malodor and hyperhidrosis of the feet, which are socially unacceptable and cause great anxiety to many of the patients...
April 2018: Acta Dermatovenerologica Croatica: ADC
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