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marine based compounds

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https://www.readbyqxmd.com/read/28330094/characterization-of-antibiotic-resistant-and-enzyme-producing-bacterial-strains-isolated-from-the-arabian-sea
#1
Preeti N Tallur, Dayanand B Sajjan, Sikandar I Mulla, Manjunatha P Talwar, A Pragasam, Vinayak M Nayak, Harichandra Z Ninnekar, Shivanand S Bhat
Marine bacteria are known to produce many bioactive molecules and extracellular enzymes of commercial importance. We have investigated the bacterial diversity of the coastal area of Karwar, Karnataka State, India. Among these bacterial isolates, five bacterial strains were selected and identified by their morphological, biochemical characteristics and phylogenetic analysis based on 16S rRNA gene sequences. The identified bacterial isolates, Bacillus toyonensis PNTB1, Lysinibacillus sphaericus PTB, Vibrio vulnificus PMD, Shewanella MPTDBS, and Pseudomonas chlororaphis PNTB were characterized for their tolerance to salt and antibiotics...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28314230/toxicity-of-diatom-polyunsaturated-aldehydes-to-marine-bacterial-isolates-reveals-their-mode-of-action
#2
Milva Pepi, Hermann J Heipieper, Cecilia Balestra, Marco Borra, Elio Biffali, Raffaella Casotti
Diatoms produce and release polyunsaturated aldehydes (PUAs) during senescence in culture and at the end of blooms in nature and these compounds play different ecological roles, as infochemicals, allelochemicals and pheromones In order to elucidate the toxic effects of PUAs, we isolated six bacterial strains from the Mediterranean Sea during a diatom bloom and tested their tolerance to PUA in terms of growth and cell membrane properties. Based upon 16S rRNA sequencing, these bacteria were assigned to the genera Pseudomonas, Sufflavibacter, Halomonas, Vibrio, Idiomarina, and Labrenzia...
March 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/28294564/cultivation-based-strategies-to-find-efficient-marine-biocatalysts
#3
Carlos J C Rodrigues, Ricardo F S Pereira, Pedro Fernandes, Joaquim M S Cabral, Carla C C R de Carvalho
Marine bacteria have evolved to survive in the marine environment by using unique physiological, biochemical and metabolic features and the ability to produce enzymes and compounds which may have commercial value. The Azores archipelago presents several ecosystems with strong volcanic activity where bacteria thrive under e.g. high temperatures. In this study, samples collected in the island of São Miguel were screened for biocatalysts possessing e.g. lipase, esterase, amylase, and inulinase activities. After isolation of several hundred bacterial strains, high throughput screening methods allowed the fast identification of biocatalysts...
March 10, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28279699/metabolic-engineering-for-the-microbial-production-of-marine-bioactive-compounds
#4
REVIEW
Xiangzhao Mao, Zhen Liu, Jianan Sun, Sang Yup Lee
Many marine bioactive compounds have medicinal and nutritional values. These bioactive compounds have been prepared using solvent-based extraction from marine bio-resources or chemical synthesis, which are costly, inefficient with low yields, and environmentally unfriendly. Recent advances in metabolic engineering allowed to some extent more efficient production of these compounds, showing promises to meet the increasing demand of marine natural bioactive compounds. In this paper, we review the strategies and statuses of metabolic engineering applied to microbial production of marine natural bioactive compounds including terpenoids and their derivatives, omega-3 polyunsaturated fatty acids, and marine natural drugs, and provide perspectives...
March 6, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28278683/metabolomics-approach-to-chemical-diversity-of-the-mediterranean-marine-sponge-agelas-oroides
#5
Pierre Sauleau, Céline Moriou, Ali Al Mourabit
The Mediterranean marine sponge Agelas oroides is known to contain a large quantity of oroidin, a deterrent, antifouling and antibiofilm pyrrole-2-aminoimidazole. In contrast with other tropical specimens, the chemical composition of Mediterranean Agelas oroides is surprisingly relatively poor in other related metabolites. In the course of finding novel marine natural products, LC-MS based metabolomics study of the Mediterranean Agelas oroides, however, revealed that next to the major compound oroidin, the sponge contains in fact a great diversity of known pyrrole-imidazole alkaloids in minute amounts...
February 6, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28278122/cadmium-lead-mercury-and-arsenic-in-animal-feed-and-feed-materials-trend-analysis-of-monitoring-results
#6
Paulien Adamse, H J Ine Van der Fels-Klerx, Jacob de Jong
This study aimed to obtain insights into the presence of cadmium, lead, mercury and arsenic in feed materials and feed over time, for the purpose of guiding national monitoring. Data from the Dutch feed monitoring program and from representatives of the feed industry in the period 2007-2013 were used. Data covered the concentrations of cadmium, lead, mercury and arsenic in a variety of feed materials and compound feeds in The Netherlands. Trends in the percentage of samples that exceeded the maximum limit (ML), set by the European Commission, and trends in average, median and 90(th) percentile concentrations of each of these elements per feed material or compound feed were investigated...
March 2, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28275987/smenospongidine-suppresses-the-proliferation-of-multiple-myeloma-cells-by-promoting-ccaat-enhancer-binding-protein-homologous-protein-mediated-%C3%AE-catenin-degradation
#7
Seoyoung Park, In Hyun Hwang, Jiseon Kim, Young-Hwa Chung, Gyu-Young Song, MinKyun Na, Sangtaek Oh
Abnormal up-regulation of β-catenin expression is associated with the development and progression of multiple myeloma and is thus a potential therapeutic target. Here, we screened cell-based natural compounds and identified smenospongidine, a metabolite isolated from a marine sponge, as an antagonist of the Wnt/β-catenin signaling pathway. Smenospongidine promoted the degradation of intracellular β-catenin that accumulated via Wnt3a or 6-bromoindirubin-3'-oxime, an inhibitor of glycogen synthase kinase-3β...
March 8, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28262987/salinity-impacts-on-water-solubility-and-n-octanol-water-partition-coefficients-of-selected-pesticides-and-oil-constituents
#8
Parichehr Saranjampour, Emily N Vebrosky, Kevin L Armbrust
Salinity has been reported to influence the water solubility of organic chemicals entering marine ecosystems. However, there is limited data available on salinity impacts for chemicals potentially entering seawater. Impacts on water solubility would correspondingly impact chemical sorption as well as overall bioavailability and exposure estimates used in the regulatory assessment. Pesticides atrazine, fipronil, bifenthrin, cypermethrin, as well as crude oil constituents dibenzothiophene as well as 3 of its alkyl derivatives all have different polarities and were selected as model compounds to demonstrate the impact of salinity on their solubility and partitioning behavior...
March 6, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28246378/fradiamine-a-a-new-siderophore-from-the-deep-sea-actinomycete-streptomyces-fradiae-mm456m-mf7
#9
Yasuhiro Takehana, Maya Umekita, Masaki Hatano, Chiaki Kato, Ryuichi Sawa, Masayuki Igarashi
New bioactive substances were identified from several marine actinomycetes strains by LC-HRESI-MS based non-targeted metabolomics. A new siderophore and its derivative, named fradiamines A and B, were isolated from the extract of the deep-sea actinomycetes Streptomyces fradiae MM456M-mF7 by Diaion CHP-20P, Sephadex LH-20 column chromatography and HPLC. Fradiamine A was a new compound, but fradiamine B was previously patented as a sweetness enhancer. Their structures were determined by NMR and LC-HRESI-MS/MS analysis...
March 1, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28241461/quorum-sensing-inhibitors-from-the-sea-discovered-using-bacterial-n-acyl-homoserine-lactone-based-biosensors
#10
REVIEW
Kumar Saurav, Valeria Costantino, Vittorio Venturi, Laura Steindler
Marine natural products with antibiotic activity have been a rich source of drug discovery; however, the emergence of antibiotic-resistant bacterial strains has turned attention towards the discovery of alternative innovative strategies to combat pathogens. In many pathogenic bacteria, the expression of virulence factors is under the regulation of quorum sensing (QS). QS inhibitors (QSIs) present a promising alternative or potential synergistic treatment since they disrupt the signaling pathway used for intra- and interspecies coordination of expression of virulence factors...
February 23, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28240166/synthesis-of-medicinally-privileged-heterocycles-through-dielectric-heating
#11
Debasish Bandyopadhyay, Bimal K Banik
This review summarizes the potential application of microwave irradiation (dielectric heating) to synthesize biologically important heterocyclic small molecules in the recent past. A huge number of heterocyclic compounds are present in various natural sources like plant, marine microbe or other organisms and many of them possess unique biological activity. In addition to nature-derived heterocyclic compounds, a large number of synthetic heterocycles are being used as medicines. This review describes the relevant recent examples of microwave irradiation to accomplish various chemical transformations accelerated by a variety of catalysts which include, but not limited to, Lewis acids, other metal containing catalysts, organocatalysts, heterogeneous catalysts, phase-transfer catalysts, solid-supported catalysts, inorganic catalysts (bases, acids and salts) and so on...
February 23, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28238037/computer-aided-drug-discovery-from-marine-compounds-identification-of-the-three-dimensional-structural-features-responsible-for-antimalarial-activity
#12
Caterina Fattorusso, Marco Persico, Francesca Rondinelli, Nausicaa Orteca, Antonio Di Dato
An integrated computational approach, based on molecular dynamics/mechanics, semi-empirical, and DFT calculations as well as dynamic docking studies, has been employed to gain insight into the mechanism of action of new antimalarial agents characterized by the scaffold of the marine compounds plakortin and aplidinone. The results of this approach show that these molecules, after interaction with Fe(II), likely coming from the heme molecule, give rise to the formation of radical species, that should represent the toxic intermediates responsible for subsequent reactions leading to plasmodium death...
2017: Progress in Molecular and Subcellular Biology
https://www.readbyqxmd.com/read/28238034/35-years-of-marine-natural-product-research-in-sweden-cool-molecules-and-models-from-cold-waters
#13
Lars Bohlin, Paco Cárdenas, Anders Backlund, Ulf Göransson
Currents efforts in marine biodiscovery have essentially focused on temperate to tropical shallow water organisms. With more than 6000 species of marine plants and animals, the Kosterfjord area has the richest marine biodiversity in Swedish waters, but it remains understudied. The overall objective of our marine pharmacognosy research is to explore and reveal the pharmacological potential of organisms from this poorly explored region. More generally, we wish to understand aspects of structure-activity relationships of chemical interactions in cold-water marine environment (shallow and deep)...
2017: Progress in Molecular and Subcellular Biology
https://www.readbyqxmd.com/read/28225766/marine-actinobacteria-as-a-source-of-compounds-for-phytopathogen-control-an-integrative-metabolic-profiling-bioactivity-and-taxonomical-approach
#14
Luz A Betancur, Sandra J Naranjo-Gaybor, Diana M Vinchira-Villarraga, Nubia C Moreno-Sarmiento, Luis A Maldonado, Zulma R Suarez-Moreno, Alejandro Acosta-González, Gillermo F Padilla-Gonzalez, Mónica Puyana, Leonardo Castellanos, Freddy A Ramos
Marine bacteria are considered as promising sources for the discovery of novel biologically active compounds. In this study, samples of sediment, invertebrate and algae were collected from the Providencia and Santa Catalina coral reef (Colombian Caribbean Sea) with the aim of isolating Actinobateria-like strain able to produce antimicrobial and quorum quenching compounds against pathogens. Several approaches were used to select actinobacterial isolates, obtaining 203 strains from all samples. According to their 16S rRNA gene sequencing, a total of 24 strains was classified within Actinobacteria represented by three genera: Streptomyces, Micromonospora, and Gordonia...
2017: PloS One
https://www.readbyqxmd.com/read/28216577/qm-hifsa-aided-structure-determination-of-succinilenes-a-d-new-triene-polyols-from-a-marine-derived-streptomyces-sp
#15
Munhyung Bae, So Hyun Park, Yun Kwon, Sang Kook Lee, Jongheon Shin, Joo-Won Nam, Dong-Chan Oh
Based on profiles of secondary metabolites produced by marine bacteria obtained using LC/MS, succinilenes A-D (1-4), new triene polyols, were discovered from a culture of a Streptomyces strain SAK1, which was collected in the southern area of Jeju Island, Republic of Korea. The gross structures of 1-4 were primarily determined through analysis of NMR spectra. The double bond geometries of the succinilenes, which could not be established from conventional ¹H NMR spectra because of the highly overlapped olefinic signals, were successfully deciphered using the recently developed quantum-mechanics-driven ¹H iterative full spin analysis (QM-HiFSA)...
February 14, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28214232/new-nitrofurans-amenable-by-isocyanide-multicomponent-chemistry-are-active-against-multidrug-resistant-and-poly-resistant-mycobacterium-tuberculosis
#16
Mikhail Krasavin, Vladislav Parchinsky, Grigory Kantin, Olga Manicheva, Marine Dogonadze, Tatiana Vinogradova, Bianka Karge, Mark Brönstrup
A set of structurally diverse N-amino δ-lactams decorated with a 5-nitro-2-furyl moiety was synthesized using isocyanide-based multicomponent chemistry and evaluated for antibacterial activity. Three compounds displayed a selective and potent (MIC 22-33μM) inhibition of M. tuberculosis H37Rv strain growth, while other Gram-positive (MRSA and E. faecium) or Gram-negative (E. coli, P. aeruginosa, A. baumannii, K. pneumoniae) pathogens were not affected. The compounds also displayed moderate-low cytotoxicity, as demonstrated in cell line viability assays...
February 4, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28213548/effects-of-gelling-agent-and-extracellular-signaling-molecules-on-the-culturability-of-marine-bacteria
#17
Anita Mac Rygaard, Mariane Schmidt Thøgersen, Kristian Fog Nielsen, Lone Gram, Mikkel Bentzon-Tilia
Only 1 % of marine bacteria are currently culturable using standard laboratory procedures and this is a major obstacle for our understanding of the biology of marine microorganisms and for the discovery of novel microbial natural products. Therefore, the purpose of the present study was to investigate if improved cultivation conditions, including the use of an alternative gelling agent, and supplementation with signaling molecules, could improve the culturability of bacteria from seawater. Substituting agar with gellan gum improved viable counts 3 - 40-fold, depending on medium composition and incubation conditions, with a maximum of 6...
February 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28208715/biotransformation-and-detoxification-of-xylidine-orange-dye-using-immobilized-cells-of-marine-derived-lysinibacillus-sphaericus-d3
#18
Prabha Devi, Solimabi Wahidullah, Farhan Sheikh, Rochelle Pereira, Niteen Narkhede, Divya Amonkar, Supriya Tilvi, Ram Murthy Meena
Lysinibacillus sphaericus D3 cell-immobilized beads in natural gel sodium alginate decolorized the xylidine orange dye 1-(dimethylphenylazo)-2-naphthol-6-sulfonic acid sodium salt in the laboratory. Optimal conditions were selected for decolorization and the products formed were evaluated for toxicity by disc diffusion assay against common marine bacteria which revealed the non-toxic nature of the dye-degraded products. Decolorization of the brightly colored dye to colorless products was measured on an Ultra Violet-Vis spectrophotometer and its biodegradation products monitored on Thin Layer Chromatographic plate and High Performance Liquid Chromatography (HPLC)...
February 8, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28163017/small-molecule-inhibitors-of-the-sox18-transcription-factor
#19
Frank Fontaine, Jeroen Overman, Mehdi Moustaqil, Sreeman Mamidyala, Angela Salim, Kamesh Narasimhan, Nina Prokoph, Avril A B Robertson, Linda Lua, Kirill Alexandrov, Peter Koopman, Robert J Capon, Emma Sierecki, Yann Gambin, Ralf Jauch, Matthew A Cooper, Johannes Zuegg, Mathias Francois
Pharmacological modulation of transcription factors (TFs) has only met little success over the past four decades. This is mostly due to standard drug discovery approaches centered on blocking protein/DNA binding or interfering with post-translational modifications. Recent advances in the field of TF biology have revealed a central role of protein-protein interaction in their mode of action. In an attempt to modulate the activity of SOX18 TF, a known regulator of vascular growth in development and disease, we screened a marine extract library for potential small-molecule inhibitors...
March 16, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28159305/microscopic-characterisation-of-black-crusts-on-different-substrates
#20
J S Pozo-Antonio, M F C Pereira, C S A Rocha
Black crusts on different substrates (carbonate and silicate stones, cement-based mortar and carbonate detrital deposits) in urban environments were characterized microscopically by analysing their morphologies and compositions. The objective of this article is to study the interaction between the substrate and the crust and the influence of the environmental conditions on the crust development. On the one hand, the internal structure and morphology of each sample were evaluated with stereo and scanning electron microscopies...
April 15, 2017: Science of the Total Environment
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