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https://www.readbyqxmd.com/read/28729856/biological-significance-of-marine-actinobacteria-of-east-coast-of-andhra-pradesh-india
#1
Alapati Kavitha, Handanahal S Savithri
An attempt was made to identify actinobacterial strains present in the marine soil of East Coast regions viz., Chirala, Bapatla, and Peddaganjam, Andhra Pradesh; Kanyakumari, Tamil Nadu and Goa, Goa along with the study of their antimicrobial potential. Eight out of 73 actinobacterial strains isolated from these regions showed strong antimicrobial activity against Gram positive bacteria, Gram negative bacteria, and Candida albicans. Molecular identification (16S rRNA analysis) of the eight strains revealed that they belong to Dietzia sp...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28720331/a-novel-antihypertension-agent-sargachromenol-d-from-marine-brown-algae-sargassum-siliquastrum-exerts-dual-action-as-an-l-type-ca-2-channel-blocker-and-endothelin-a-b2-receptor-antagonist
#2
Byong-Gon Park, Woon-Seob Shin, Sangtae Oh, Gab-Man Park, Nam Ik Kim, Seokjoon Lee
We isolated the novel vasoactive marine natural products, (5E,10E)-14-hydroxy-2,6,10-trimethylpentadeca-5,10-dien-4-one (4) and sargachromenol D (5), from Sargassum siliquastrum collected from the coast of the East Sea in South Korea by using activity-guided HPLC purification. The compounds effectively dilated depolarization (50mMK(+))-induced basilar artery contraction with EC50 values of 3.52±0.42 and 1.62±0.63μM, respectively, but only sargachromenol D (5) showed a vasodilatory effect on endothelin-1 (ET-1)-induced basilar artery contraction (EC50=9...
July 6, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28717220/imaging-mass-spectrometry-and-ms-ms-molecular-networking-reveals-chemical-interactions-among-cuticular-bacteria-and-pathogenic-fungi-associated-with-fungus-growing-ants
#3
Cristopher A Boya P, Hermógenes Fernández-Marín, Luis C Mejía, Carmenza Spadafora, Pieter C Dorrestein, Marcelino Gutiérrez
The fungus-growing ant-microbe symbiosis is an ideal system to study chemistry-based microbial interactions due to the wealth of microbial interactions described, and the lack of information on the molecules involved therein. In this study, we employed a combination of MALDI imaging mass spectrometry (MALDI-IMS) and MS/MS molecular networking to study chemistry-based microbial interactions in this system. MALDI IMS was used to visualize the distribution of antimicrobials at the inhibition zone between bacteria associated to the ant Acromyrmex echinatior and the fungal pathogen Escovopsis sp...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28713339/concurrent-methane-production-and-oxidation-in-surface-sediment-from-aarhus-bay-denmark
#4
Ke-Qing Xiao, Felix Beulig, Kasper U Kjeldsen, Bo B Jørgensen, Nils Risgaard-Petersen
Marine surface sediments, which are replete with sulfate, are typically considered to be devoid of endogenous methanogenesis. Yet, methanogenic archaea are present in those sediments, suggesting a potential for methanogenesis. We used an isotope dilution method based on sediment bag incubation and spiking with (13)C-CH4 to quantify CH4 turnover rates in sediment from Aarhus Bay, Denmark. In two independent experiments, highest CH4 production and oxidation rates (>200 pmol cm(-3) d(-1)) were found in the top 0-2 cm, below which rates dropped below 100 pmol cm(-3) d(-1) in all other segments down to 16 cm...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28711841/free-amino-acids-in-the-arctic-snow-and-ice-core-samples-potential-markers-for-paleoclimatic-studies
#5
Elena Barbaro, Andrea Spolaor, Ornela Karroca, Ki-Tae Park, Tõnu Martma, Elisabeth Isaksson, Jack Kohler, Jean Charles Gallet, Mats P Bjorkman, David Cappelletti, Gunnar Spreen, Roberta Zangrando, Carlo Barbante, Andrea Gambaro
The role of oceanic primary production on climate variability has long been debated. Defining changes in past oceanic primary production can help understanding of the important role that marine algae have in climate variability. In ice core research methanesulfonic acid is the chemical marker commonly used for assessing changes in past primary production. However, other organic compounds such as amino acids, can be produced and emitted into the atmosphere during a phytoplankton bloom. These species can be transported and deposited onto the ice cap in polar regions...
July 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28699746/assignment-of-the-absolute-configuration-of-phosphoeleganin-via-synthesis-of-model-compounds
#6
Paolo Luciano, Concetta Imperatore, Maria Senese, Anna Aiello, Marcello Casertano, Yue-W Guo, Marialuisa Menna
The full absolute configuration assignment of phosphoeleganin (1), a recently discovered marine-derived phosphorylated polyketide with protein tyrosine phosphatase 1B inhibitory activity, was achieved. It was based on the synthesis of model diasteroisomeric compounds of the C-8-C-12 segment portion of phosphoeleganin, chiral derivatization methods, and application of the universal NMR database concept.
July 12, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28698495/discovery-of-dna-topoisomerase-i-inhibitors-with-low-cytotoxicity-based-on-virtual-screening-from-natural-products
#7
Lan-Ting Xin, Lu Liu, Chang-Lun Shao, Ri-Lei Yu, Fang-Ling Chen, Shi-Jun Yue, Mei Wang, Zhong-Long Guo, Ya-Chu Fan, Hua-Shi Guan, Chang-Yun Wang
Currently, DNA topoisomerase I (Topo I) inhibitors constitute a family of antitumor agents with demonstrated clinical effects on human malignancies. However, the clinical uses of these agents have been greatly limited due to their severe toxic effects. Therefore, it is urgent to find and develop novel low toxic Topo I inhibitors. In recent years, during our ongoing research on natural antitumor products, a collection of low cytotoxic or non-cytotoxic compounds with various structures were identified from marine invertebrates, plants, and their symbiotic microorganisms...
July 9, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28690604/phenol-is-the-initial-product-formed-during-growth-and-degradation-of-bromobenzene-by-tropical-marine-yeast-yarrowia-lipolytica-ncim-3589-via-an-early-dehalogenation-step
#8
Aakanksha A Vatsal, Smita S Zinjarde, Ameeta RaviKumar
Bromobenzene (BrB), a hydrophobic, recalcitrant organic compound, is listed by the environmental protection agencies as an environmental and marine pollutant having hepatotoxic, mutagenic, teratogenic, and carcinogenic effects. The tropical marine yeast Yarrowia lipolytica 3589 was seen to grow aerobically on BrB and displayed a maximum growth rate (μmax) of 0.04 h(-1). Furthermore, we also observed an increase in cell size and sedimentation velocity for the cells grown on BrB as compared to the glucose grown cells...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28690598/large-diversity-and-original-structures-of-acyl-homoserine-lactones-in-strain-mola-401-a-marine-rhodobacteraceae-bacterium
#9
Margot Doberva, Didier Stien, Jonathan Sorres, Nathalie Hue, Sophie Sanchez-Ferandin, Véronique Eparvier, Yoan Ferandin, Philippe Lebaron, Raphaël Lami
Quorum sensing (QS) is a density-dependent mechanism allowing bacteria to synchronize their physiological activities, mediated by a wide range of signaling molecules including N-acyl-homoserine lactones (AHLs). Production of AHL has been identified in various marine strains of Proteobacteria. However, the chemical diversity of these molecules still needs to be further explored. In this study, we examined the diversity of AHLs produced by strain MOLA 401, a marine Alphaproteobacterium that belongs to the ubiquitous Rhodobacteraceae family...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28687647/the-deep-sea-bacterium-shewanella-piezotolerans-wp3-has-two-dmso-reductases-in-distinct-subcellular-locations
#10
Lei Xiong, Huahua Jian, Xiang Xiao
Dimethyl sulfoxide (DMSO) acts as a substantial sink for dimethyl sulfide (DMS) in deep waters and is therefore considered a potential electron acceptor supporting abyssal ecosystems. Shewanella piezotolerans WP3 was isolated from west Pacific deep-sea sediments, and two functional DMSO respiratory subsystems are essential for maximum growth of WP3 under in situ conditions (4°C/20 MPa). However, the relationship between these two subsystems and the electron transport pathway underlying DMSO reduction by WP3 remain unknown...
July 7, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28678182/producing-novel-fibrinolytic-isoindolinone-derivatives-in-marine-fungus-stachybotrys-longispora-fg216-by-the-rational-supply-of-amino-compounds-according-to-its-biosynthesis-pathway
#11
Ying Yin, Qiang Fu, Wenhui Wu, Menghao Cai, Xiangshan Zhou, Yuanxing Zhang
Many fungi in the Stachybotrys genus can produce various isoindolinone derivatives. These compounds are formed by a spontaneous reaction between a phthalic aldehyde precursor and an ammonium ion or amino compounds. In this study, we suggested the isoindolinone biosynthetic gene cluster in Stachybotrys by genome mining based on three reported core genes. Remarkably, there is an additional nitrate reductase (NR) gene copy in the proposed cluster. NR is the rate-limiting enzyme of nitrate reduction. Accordingly, this cluster was speculated to play a role in the balance of ammonium ion concentration in Stachybotrys...
July 5, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28669076/isolation-identification-optimization-and-metabolite-profiling-of-streptomyces-sparsus-vsm-30
#12
Ushakiranmayi Managamuri, Muvva Vijayalakshmi, V S Rama Krishna Ganduri, Satish Babu Rajulapati, Bodaiah Bonigala, B S Kalyani, Sudhakar Poda
Deep sea sediment samples of Bay of Bengal (Visakhapatnam) have been analyzed for actinomycetes as an elite source to screen for the production of bioactive metabolites. The actinomycetes strain VSM-30 has an exciting bioactivity profile and was isolated during our systemic screening of marine actinomycetes. It was identified as Streptomyces sparsus based on morphological, physiological, biochemical, and molecular approaches. Response surface methodology regression analysis was carried out to fit the experimental data of each response by the second-order polynomial...
July 2017: 3 Biotech
https://www.readbyqxmd.com/read/28663279/comparative-exploration-of-the-structure-activity-space-of-cloned-%C3%AE-like-octopamine-receptors-from-a-marine-and-a-terrestrial-arthropod
#13
Dhwanil A Dalwadi, John A Schetz
The α-like octopamine receptors are believed to be the evolutionary precursor to the vertebrate α2-adrenergic receptors (α2-ARs) based upon sequence similarity and the ability to interact with norepinephrine and a number of compounds that bind with high affinity to α2-ARs. Barnacles and fruit flies are two prominent model marine and terrestrial representatives of the Arthropoda phylum, and while α-like OctRs have been cloned from Balanus improvisus (BiOctR) and Drosophila melanogaster (DmOctR), little is known about the structure-activity space for these important species...
June 29, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28661419/design-synthesis-and-antifouling-activity-of-glucosamine-based-isocyanides
#14
Taiki Umezawa, Yuki Hasegawa, Ira S Novita, Junya Suzuki, Tatsuya Morozumi, Yasuyuki Nogata, Erina Yoshimura, Fuyuhiko Matsuda
Biofouling, an undesirable accumulation of organisms on sea-immersed structures such as ship hulls and fishing nets, is a serious economic issue whose effects include oil wastage and clogged nets. Organotin compounds were utilized since the 1960s as an antifouling material; however, the use of such compounds was later banned by the International Maritime Organization (IMO) due to their high toxicity toward marine organisms, resulting in masculinization and imposex. Since the ban, there have been extensive efforts to develop environmentally benign antifoulants...
June 29, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28653930/identification-and-growth-optimization-of-a-marine-bacillus-dk1-sa11-having-potential-of-producing-broad-spectrum-antimicrobial-compounds
#15
Muhammad Naseem Khan, Hong Lin, Meng Li, Jingxue Wang, Zulfiqar Ali Mirani, Seema Ismat Khan, Muhammad Aslam Buzdar, Imran Ali, Khalid Jamil
Control of harmful bacteria in food, aquaculture, pharmaceuticals, agriculture, hospitals and recreation water pools are of great global concern. Marine bacteria are an enormous source of bio-controlling agents. The aim of this study was to identify and optimize the growth conditions including effect of different biotic and abiotic factors on antimicrobial activity of strain DK1-SA11 isolated from Qingdao Bay of China Yellow Sea. Microscopic characterization, API® 20E and 50 CHB kit base carbohydrates utilization, 16S rDNA and DNA gyrB gene sequencing studies identified the bacterium as Bacillus subtilis subsp...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28648045/first-identification-of-palytoxin-like-molecules-in-the-atlantic-coral-species-palythoa-canariensis
#16
María Fraga, Natalia Vilariño, M Carmen Louzao, Lucía Molina, Yanira López, Mark Poli, Luis M Botana
Palytoxin (PLTX) is a complex marine toxin produced by Zoanthids (Palyhtoa), dinoflagellates (Ostreopsis), and cyanobacteria (Trichodesmium). Contact with PLTX-like compounds present in aerosols or marine organisms has been associated with adverse effects on humans. The worldwide distribution of producer species and seafood contaminated with PLTX-like molecules illustrates the global threat to human health. The identification of species capable of palytoxin production is critical for human safety. We studied the presence of PLTX analogues in Palythoa canariensis, a coral species collected in the Atlantic Ocean never described as a PLTX-producer before...
July 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28644406/an-updated-review-on-marine-anticancer-compounds-the-use-of-virtual-screening-for-the-discovery-of-small-molecule-cancer-drugs
#17
REVIEW
Verónica Ruiz-Torres, Jose Antonio Encinar, María Herranz-López, Almudena Pérez-Sánchez, Vicente Galiano, Enrique Barrajón-Catalán, Vicente Micol
Marine secondary metabolites are a promising source of unexploited drugs that have a wide structural diversity and have shown a variety of biological activities. These compounds are produced in response to the harsh and competitive conditions that occur in the marine environment. Invertebrates are considered to be among the groups with the richest biodiversity. To date, a significant number of marine natural products (MNPs) have been established as antineoplastic drugs. This review gives an overview of MNPs, both in research or clinical stages, from diverse organisms that were reported as being active or potentially active in cancer treatment in the past seventeen years (from January 2000 until April 2017) and describes their putative mechanisms of action...
June 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28630316/recombinant-silicateins-as-model-biocatalysts-in-organosiloxane-chemistry
#18
S Yasin Tabatabaei Dakhili, Stephanie A Caslin, Abayomi S Faponle, Peter Quayle, Sam P de Visser, Lu Shin Wong
The family of silicatein enzymes from marine sponges (phylum Porifera) is unique in nature for catalyzing the formation of inorganic silica structures, which the organisms incorporate into their skeleton. However, the synthesis of organosiloxanes catalyzed by these enzymes has thus far remained largely unexplored. To investigate the reactivity of these enzymes in relation to this important class of compounds, their catalysis of Si-O bond hydrolysis and condensation was investigated with a range of model organosilanols and silyl ethers...
July 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28618302/growth-and-physiological-responses-of-a-marine-diatom-phaeodactylum-tricornutum-against-two-imidazolium-based-ionic-liquids-c4mim-bf4-and-c8mim-bf4
#19
Xiang-Yuan Deng, Biao Chen, Da Li, Xiao-Li Hu, Jie Cheng, Kun Gao, Chang-Hai Wang
Ionic liquids (ILs) have been considered as "green" substitutes for traditional organic solvents in many existing biological and chemical areas. However, they have high solubility and poor biodegradability in water, suggesting that they could become persistent chemical pollutants in aquatic environment. The ability of two widely used imidazolium-based ILs to affect the growth and physiological characteristics of a marine diatom (Phaeodactylum tricornutum) was investigated in this study. The diatom was exposed to different concentrations of 1-butyl-3-methylimidazolium tetrafluoroborate ([C4mim]BF4) and 1-octyl-3-methylimidazolium tetrafluoroborate ([C8mim]BF4) for 96h within a batch-culture system...
May 31, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28609736/effects-of-continental-anthropogenic-sources-on-organic-aerosols-in-the-coastal-atmosphere-of-east-china
#20
Dongjie Shang, Min Hu, Qingfeng Guo, Qi Zou, Jing Zheng, Song Guo
Although organic compounds in marine atmospheric aerosols have significant effects on climate and marine ecosystems, they have rarely been studied, especially in the coastal regions of East China. To assess the origins of the organic aerosols in the East China coastal atmosphere, PM2.5 samples were collected from the atmospheres of the Yellow Sea, the East China Sea, and Changdao Island during the CAPTAIN (Campaign of Air PolluTion At INshore Areas of Eastern China) field campaign in the spring of 2011. The marine atmospheric aerosol samples that were collected were grouped based on the backward trajectories of their air masses...
June 10, 2017: Environmental Pollution
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