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https://www.readbyqxmd.com/read/29211005/isolation-of-petrocidin-a-a-new-cytotoxic-cyclic-dipeptide-from-the-marine-sponge-derived-bacterium-streptomyces-sp-sbt348
#1
Cheng Cheng, Eman M Othman, Helga Stopper, RuAngelie Edrada-Ebel, Ute Hentschel, Usama Ramadan Abdelmohsen
A new cyclic dipeptide, petrocidin A (1), along with three known compounds-2,3-dihydroxybenzoic acid (2), 2,3-dihydroxybenzamide (3), and maltol (4)-were isolated from the solid culture of Streptomyces sp. SBT348. The strain Streptomyces sp. SBT348 had been prioritized in a strain collection of 64 sponge-associated actinomycetes based on its distinct metabolomic profile using liquid chromatography/high-resolution mass spectrometry (LC-HRMS) and nuclear magnetic resonance (NMR). The absolute configuration of all α-amino acids was determined by HPLC analysis after derivatization with Marfey's reagent and comparison with commercially available reference amino acids...
December 6, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29209860/identification-of-inhibitory-compounds-against-singapore-grouper-iridovirus-infection-by-cell-viability-based-screening-assay-and-droplet-digital-pcr
#2
Kuntong Jia, Yongming Yuan, Wei Liu, Lan Liu, Qiwei Qin, Meisheng Yi
Singapore grouper iridovirus (SGIV) is one of the major causative agents of fish diseases and has caused significant economic losses in the aquaculture industry. There is currently no commercial vaccine or effective antiviral treatment against SGIV infection. Annually, an increasing number of small molecule compounds from various sources have been produced, and many are proved to be potential inhibitors against viruses. Here, a high-throughput in vitro cell viability-based screening assay was developed to identify antiviral compounds against SGIV using the luminescent-based CellTiter-Glo reagent in cultured grouper spleen cells by quantificational measurement of the cytopathic effects induced by SGIV infection...
December 5, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/29209282/identification-and-analysis-of-novel-inhibitors-against-ns3-helicase-and-ns5b-rna-dependent-rna-polymerase-from-hepatitis-c-virus-1b-con1
#3
Na Yang, Chaomin Sun, Lixin Zhang, Jianguo Liu, Fuhang Song
Hepatitis C virus (HCV) leads to severe liver diseases, including liver fibrosis, cirrhosis and hepatocellular carcinoma. Non-structural protein 3 helicase (NS3h) and non-structural protein 5B RNA-dependent RNA polymerase (NS5B) are involved in the replication of HCV RNA genome, and have been proved to be excellent targets for discovery of direct-acting antivirals. In this study, two high-throughput screening systems, fluorescence polarization (FP)-based ssDNA binding assay and fluorescence intensity (FI)-based dsRNA formation assay, were constructed to identify candidate NS3h and NS5B inhibitors, respectively...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29198862/towards-smart-biocide-free-anti-biofilm-strategies-click-based-synthesis-of-cinnamide-analogues-as-anti-biofilm-compounds-against-marine-bacteria
#4
C Sall, M Ayé, O Bottzeck, A Praud, Y Blache
A set of triazole-based analogues of N-coumaroyltyramine was designed to discover potential leads that may help in the control of bacterial biofilms. the most potent compounds act as inhibitors of biofilm development with EC50 closed to ampicillin (EC50 = 11 μM) without toxic effect on bacterial growth even at high concentrations(100 μM).
November 24, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29182331/polyoxygenated-steroids-from-the-sponge-clathria-gombawuiensis
#5
Jung-Kyun Woo, Thi Kim Quy Ha, Dong-Chan Oh, Won-Keun Oh, Ki-Bong Oh, Jongheon Shin
Six new polyoxygenated steroids (1-6) along with clathriol (7) were isolated from the Korean marine sponge Clathria gombawuiensis. Based upon the results of combined spectroscopic analyses, the structures of gombasterols A-F (1-6) were elucidated to be those of highly oxygenated steroids possessing a 3β,4α,6α,7β-tetrahydroxy or equivalent (7β-sodium O-sulfonato for 3) substitution pattern and a C-15 keto group as common structural motifs. The relative and absolute configurations of these steroids, including the rare 14β configuration of 1-4, were determined by a combination of NOESY, J-based analyses, the 2-methoxy-2-(trifluoromethyl)phenylacetic acid (MTPA) method, and X-ray crystallographic analysis...
November 28, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29148756/inhibitory-activities-of-compounds-from-the-marine-actinomycete-williamsia-sp-mccc-1a11233-variant-on-ige-mediated-mast-cells-and-passive-cutaneous-anaphylaxis
#6
Yuanyuan Gao, Qingmei Liu, Bo Liu, Chun-Lan Xie, Min-Jie Cao, Xian-Wen Yang, Guang-Ming Liu
Compounds of the deep-sea-derived marine Williamsia sp. MCCC 1A11233 (CDMW), which are secondary metabolites of the actinomycetes, were isolated. In this study, seven kinds of CDMW were found to decrease degranulation and histamine release in immunoglobulin E (IgE)-mediated rat basophilic leukemia (RBL)-2H3 cells. The production of cytokines (tumor necrosis factor-α and interleukin-4) was inhibited by these CDMW in RBL-2H3 cells, and their chemical structures were established mainly based on detailed analysis of their NMR spectra...
November 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29146256/isolation-purification-structural-elucidation-and-antimicrobial-activities-of-kocumarin-a-novel-antibiotic-isolated-from-actinobacterium-kocuria-marina-cmg-s2-associated-with-the-brown-seaweed-pelvetia-canaliculata
#7
Bushra Uzair, Farid Menaa, Barkat Ali Khan, Faryal Vali Mohammad, Viqar Uddin Ahmad, Ryad Djeribi, Bouzid Menaa
AIMS: Screening of seaweed-associated bacteria capable of producing antimicrobials. METHODS AND RESULTS: Fifteen microbial strains, associated to the brown seaweed Pelvetia canaliculata (Linnaeus) attached to the rocks of Sonmiani Beach (Karachi, Pakistan), were screened. Crude extract filtrates of CMG S2 strain grew on Zobell marine agar (ZMA) had the most remarkable antimicrobial activity. Based on its phenotypic aspects (e.g. Gram-positive, microccoid form), biochemical characteristics (e...
January 2018: Microbiological Research
https://www.readbyqxmd.com/read/29144750/investigation-of-the-physical-and-bioactive-properties-of-bromo-and-iodo-containing-sponge-derived-compounds-possessing-an-oxyphenylethanamine-core
#8
Erin P McCauley, Hanh Lam, Nicholas Lorig-Roach, Justin Luu, Cameron Lloyd, Karen Tenney, Halina Pietraszkiewicz, Cristina Diaz, Frederick A Valeriote, Victoria Auerbuch, Phillip Crews
This research set out to identify compounds from marine sponges that can act as bacterial virulence blockers. Extracts from a total of 80 sponges collected from throughout Indonesia were screened in a high-throughput NF-κB-based screen that identifies compounds capable of inhibiting the bacterial type III secretion system (T3SS) in Yersinia pseudotuberculosis. An extract that was shown to inhibit T3SS-driven NF-κB expression was obtained from an Iotrochota cf. iota sponge and was the source of seven new bromo- and iodo-containing compounds, all of which contain a 2-(4-oxyphenyl)ethan-1-amine core...
November 16, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29143030/quantitative-chemoproteomic-profiling-reveals-multiple-target-interactions-of-spongiolactone-derivatives-in-leukemia-cells
#9
M H Wright, Y Tao, J Drechsel, J Krysiak, S Chamni, A Weigert-Munoz, N L Harvey, D Romo, S A Sieber
The spongiolactones are marine natural products with an unusual rearranged spongiane skeleton and a fused β-lactone ring. These compounds have potential anticancer properties but their mode of action has yet to be explored. Here we employ activity-based protein profiling to identify the targets of a more potent spongiolactone derivative in live cancer cells, and compare these to the targets of a simpler β-lactone. These hits provide the first insights into the covalent mechanism of action of this natural product class...
November 16, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29119384/tributyltin-advancing-the-science-on-assessing-endocrine-disruption-with-an-unconventional-endocrine-disrupting-compound
#10
Laurent Lagadic, Ioanna Katsiadaki, Ron Biever, Patrick D Guiney, Natalie Karouna-Renier, Tamar Schwarz, James P Meador
Tributyltin (TBT) has been recognized as an endocrine disrupting chemical (EDC) for several decades. However, only in the last decade, was its primary endocrine mechanism of action (MeOA) elucidated-interactions with the nuclear retinoid-X receptor (RXR), peroxisome proliferator-activated receptor γ (PPARγ), and their heterodimers. This molecular initiating event (MIE) alters a range of reproductive, developmental, and metabolic pathways at the organism level. It is noteworthy that a variety of MeOAs have been proposed over the years for the observed endocrine-type effects of TBT; however, convincing data for the MIE was provided only recently and now several researchers have confirmed and refined the information on this MeOA...
November 9, 2017: Reviews of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29115831/bacilotetrins-a-and-b-anti-staphylococcal-cyclic-lipotetrapeptides-from-a-marine-derived-bacillus-subtilis
#11
Fakir Shahidullah Tareq, Hee Jae Shin
LC-MS and NMR spectroscopy guided metabolic profiling and dereplication of a crude extract obtained from the fermentation of a marine-derived bacterium, Bacillus subtilis, followed by chromatographic isolation yielded two new cyclic-lipotetrapeptides, bacilotetrins A (1) and B (2). Based on extensive 1D and 2D NMR and high-resolution ESIMS data analysis, the structures of 1 and 2 were elucidated, revealing the unique structures of these lipopeptides consisting of three leucines and a glutamic acid residue cyclized with a lipophilic 3-hydroxy fatty acid...
November 8, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29112842/occurrence-and-geodatabase-mapping-of-three-contaminants-of-emerging-concern-in-receiving-water-and-at-effluent-from-waste-water-treatment-plants-a-first-overview-of-the-situation-in-the-republic-of-ireland
#12
REVIEW
Alexandre Tahar, Erin Jo Tiedeken, Neil J Rowan
This constitutes the first study to address occurrence and geodatabase mapping of the anti-inflammatory drug diclofenac (DCL) and the natural (17-beta-estradiol or E2) and synthetic (17-alpha-ethynylestradiol or EE2) estrogenic hormones in Republic of Ireland receiving waters over the period 1999 to 2015. Among these data, 317 samples came from concentration studies, while 205 were from effect-based studies. Monitoring data came from 16 waste water treatment plants (WWTPs), 23 water bodies (including rivers, lakes, marine and transitional waters) and 7 from domestic locations...
November 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29112383/ozone-formation-induced-by-the-impact-of-reactive-bromine-and-iodine-species-on-photochemistry-in-a-polluted-marine-environment
#13
Moshe Shechner, Eran Tas
Reactive iodine and bromine species (RIS and RBS, respectively) are known for altering atmospheric chemistry, causing sharp tropospheric ozone (O3) depletion in polar regions and significant O3 reduction in the marine boundary layer (MBL). Here we use measurement-based modelling to show that, unexpectedly, both RIS and RBS can lead to enhanced O3 formation in a polluted marine environment under volatile organic compound (VOC)-limited conditions associated with high nitrogen oxide (NOX = [NO] + [NO2]) concentrations...
November 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29110623/a-review-of-the-components-of-seaweeds-as-potential-candidates-in-cancer-therapy
#14
Ban-Feng Ruan, Wei-Wei Ge, Meng-Xue Lin, Qing-Shan Li
The marine natural products (MNPs) isolated from seaweeds-associated microbial communities have been caused a substantial part of attention owing to their exceptional nutritional and pharmacology application, such as antiviral, anticancer, antiprotozoal, antifungal, and antibacterial properties and so on. Particularly, there are several MNPs have been displayed attractive value for developing novel anticancer agents for clinical application. This review covers the literature published in the recent 5 years for the isolation and identification of novel anticancer MNPs from seaweeds...
November 6, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29107991/structure-and-function-of-a-ce4-deacetylase-isolated-from-a-marine-environment
#15
Tina Rise Tuveng, Ulli Rothweiler, Gupta Udatha, Gustav Vaaje-Kolstad, Arne Smalås, Vincent G H Eijsink
Chitin, a polymer of β(1-4)-linked N-acetylglucosamine found in e.g. arthropods, is a valuable resource that may be used to produce chitosan and chitooligosaccharides, two compounds with considerable industrial and biomedical potential. Deacetylating enzymes may be used to tailor the properties of chitin and its derived products. Here, we describe a novel CE4 enzyme originating from a marine Arthrobacter species (ArCE4A). Crystal structures of this novel deacetylase were determined, with and without bound chitobiose [(GlcNAc)2], and refined to 2...
2017: PloS One
https://www.readbyqxmd.com/read/29105344/disruption-of-n-acyl-homoserine-lactone-specific-signalling-and-virulence-in-clinical-pathogens-by-marine-sponge-bacteria
#16
José A Gutiérrez-Barranquero, F Jerry Reen, María L Parages, Ronan McCarthy, Alan D W Dobson, Fergal O'Gara
In recent years, the marine environment has been the subject of increasing attention from biotechnological and pharmaceutical industries. A combination of unique physicochemical properties and spatial niche-specific substrates, in wide-ranging and extreme habitats, underscores the potential of the marine environment to deliver on functionally novel bioactivities. One such area of ongoing research is the discovery of compounds that interfere with the cell-cell signalling process called quorum sensing (QS). Described as the next generation of antimicrobials, these compounds can target virulence and persistence of clinically relevant pathogens, independent of any growth-limiting effects...
November 3, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/29099042/insight-into-the-mechanism-of-action-of-marine-cytotoxic-thiazinoquinones
#17
Concetta Imperatore, Paola Cimino, Gerardo Cebrián-Torrejón, Marco Persico, Anna Aiello, Maria Senese, Caterina Fattorusso, Marialuisa Menna, Antonio Doménech-Carbó
The electrochemical response of four natural cytotoxic thiazinoquinones isolated from the Aplidium species was studied using conventional solution-phase and solid-state techniques, based on the voltammetry of immobilized particles methodology. The interaction with O₂ and electrochemically generated reactive oxygen species (ROS) was electrochemically monitored. At the same time, a molecular modeling study including density functional theory (DFT) calculations was performed in order to analyze the conformational and electronic properties of the natural thiazinoquinones, as well as those of their reduced intermediates...
November 2, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29096660/marinobacter-sp-from-marine-sediments-produce-highly-stable-surface-active-agents-for-combatting-marine-oil-spills
#18
Noura Raddadi, Lucia Giacomucci, Grazia Totaro, Fabio Fava
BACKGROUND: The application of chemical dispersants as a response to marine oil spills is raising concerns related to their potential toxicity also towards microbes involved in oil biodegradation. Hence, oil spills occurring under marine environments necessitate the application of biodispersants that are highly active, stable and effective under marine environment context. Biosurfactants from marine bacteria could be good candidates for the development of biodispersant formulations effective in marine environment...
November 2, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/29096312/tracking-major-endocrine-disruptors-in-coastal-waters-using-an-integrative-approach-coupling-field-based-study-and-hydrodynamic-modeling
#19
Elvis Genbo Xu, S N Chan, K W Choi, Joseph H W Lee, Kenneth M Y Leung
Many of the world's large coastal cities discharge partially treated wastewater effluents containing various endocrine disrupting chemicals (EDCs) to coastal environments. Nonylphenols (NP) and bisphenol A (BPA) were found to be the most abundant EDCs in sewage effluents in Hong Kong. The environmental fate and ecological risk of these two EDCs remains largely unknown, particular for coastal systems with complex hydrodynamic flows. Based on a validated three-dimensional (3D) multiple-scale hydrodynamic model, a field-based study was conducted to track the two EDCs from potential sources to the only marine reserve in Hong Kong...
October 30, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29091816/chemical-analysis-of-the-alphaproteobacterium-strain-mola1416-associated-with-the-marine-lichen-lichina-pygmaea
#20
Delphine Parrot, Laurent Intertaglia, Philippe Jehan, Martin Grube, Marcelino T Suzuki, Sophie Tomasi
Alphaproteobacterium strain MOLA1416, related to Mycoplana ramosa DSM 7292 and Chelativorans intermedius CC-MHSW-5 (93.6% 16S rRNA sequence identity) was isolated from the marine lichen, Lichina pygmaea and its chemical composition was characterized by a metabolomic network analysis using LC-MS/MS data. Twenty-five putative different compounds were revealed using a dereplication workflow based on MS/MS signatures available through GNPS (https://gnps.ucsd.edu/). In total, ten chemical families were highlighted including isocoumarins, macrolactones, erythrinan alkaloids, prodiginines, isoflavones, cyclohexane-diones, sterols, diketopiperazines, amino-acids and most likely glucocorticoids...
October 29, 2017: Phytochemistry
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