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https://www.readbyqxmd.com/read/29683350/discovery-of-a-new-biphenyl-derivative-by-epigenetic-manipulation-of-marine-derived-fungus-aspergillus-versicolor
#1
Jing Xuan Zhu, Lijian Ding, Shan He
Cultivation of the marine-derived Aspergillus versicolor MCCC 3A00080 with the addition of a histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), significantly enhanced the diversity of secondary metabolites. From the culture treated, a new biphenyl derivative, named versiperol A (1), along with two known compounds, 2,4-dimethoxyphenol (2) and diorcinol (3) were isolated. The structures of 1-3 were established based on spectroscopic analysis and comparison with literature data. Among the isolates, versiperol A (1) exhibited modest inhibition of Staphylococcus aureus growth with MIC value of 8 μg/mL...
April 23, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29672015/zebrafish-based-discovery-of-antiseizure-compounds-from-the-red-sea-pseurotin-a-2-and-azaspirofuran-a
#2
Daniëlle Copmans, Mostafa Rateb, Jioji N Tabudravu, Mercedes Pérez-Bonilla, Nina Dirkx, Riccardo Vallorani, Caridad Diaz, José Pérez Del Palacio, Alan J Smith, Rainer Ebel, Fernando Reyes, Marcel Jaspars, Peter A M de Witte
In search for novel antiseizure drugs (ASDs), the European FP7-funded PharmaSea project used zebrafish embryos and larvae as a drug discovery platform to screen marine natural products to identify promising antiseizure hits in vivo for further development. Within the framework of this project, seven known heterospirocyclic γ-lactams, namely, pseurotin A, pseurotin A2 , pseurotin F1, 11- O-methylpseurotin A, pseurotin D, azaspirofuran A, and azaspirofuran B, were isolated from the bioactive marine fungus Aspergillus fumigatus, and their antiseizure activity was evaluated in the larval zebrafish pentylenetetrazole (PTZ) seizure model...
April 19, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29671115/utility-of-dna-rna-protein-and-functional-approaches-to-solve-cryptic-immunodeficiencies
#3
Margot A Cousin, Matthew J Smith, Ashley N Sigafoos, Jay J Jin, Marine I Murphree, Nicole J Boczek, Patrick R Blackburn, Gavin R Oliver, Ross A Aleff, Karl J Clark, Eric D Wieben, Avni Y Joshi, Pavel N Pichurin, Roshini S Abraham, Eric W Klee
PURPOSE: We report a female infant identified by newborn screening for severe combined immunodeficiencies (NBS SCID) with T cell lymphopenia (TCL). The patient had persistently elevated alpha-fetoprotein (AFP) with IgA deficiency, and elevated IgM. Gene sequencing for a SCID panel was uninformative. We sought to determine the cause of the immunodeficiency in this infant. METHODS: We performed whole-exome sequencing (WES) on the patient and parents to identify a genetic diagnosis...
April 18, 2018: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29662472/direct-growth-of-bacteria-in-headspace-vials-allows-for-screening-of-volatiles-by-gas-chromatography-mass-spectrometry
#4
Collin M Timm, Evan P Lloyd, Amanda Egan, Ray Mariner, David Karig
Bacterially produced volatile organic compounds (VOCs) can modify growth patterns of eukaryotic hosts and competing/cohabiting microbes. These compounds have been implicated in skin disorders and attraction of biting pests. Current methods to detect and characterize VOCs from microbial cultures can be laborious and low-throughput, making it difficult to understand the behavior of microbial populations. In this work we present an efficient method employing gas chromatography/mass spectrometry with autosampling to characterize VOC profiles from solid-phase bacterial cultures...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29642488/sinularin-selectively-kills-breast-cancer-cells-showing-g2-m-arrest-apoptosis-and-oxidative-dna-damage
#5
Hurng-Wern Huang, Jen-Yang Tang, Fu Ou-Yang, Hui-Ru Wang, Pei-Ying Guan, Chiung-Yao Huang, Chung-Yi Chen, Ming-Feng Hou, Jyh-Horng Sheu, Hsueh-Wei Chang
The natural compound sinularin, isolated from marine soft corals, is antiproliferative against several cancers, but its possible selective killing effect has rarely been investigated. This study investigates the selective killing potential and mechanisms of sinularin-treated breast cancer cells. In 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H- tetrazolium, inner salt (MTS) assay, sinularin dose-responsively decreased the cell viability of two breast cancer (SKBR3 and MDA-MB-231) cells, but showed less effect on breast normal (M10) cells after a 24 h treatment...
April 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29627550/speciation-of-organic-fractions-does-matter-for-aerosol-source-apportionment-part-2-intensive-short-term-campaign-in-the-paris-area-france
#6
D Srivastava, O Favez, N Bonnaire, F Lucarelli, M Haeffelin, E Perraudin, V Gros, E Villenave, A Albinet
The present study aimed at performing PM10 source apportionment, using positive matrix factorization (PMF), based on filter samples collected every 4h at a sub-urban station in the Paris region (France) during a PM pollution event in March 2015 (PM10 >50μgm-3 for several consecutive days). The PMF model allowed to deconvolve 11 source factors. The use of specific primary and secondary organic molecular markers favoured the determination of common sources such as biomass burning and primary traffic emissions, as well as 2 specific biogenic SOA (marine+isoprene) and 3 anthropogenic SOA (nitro-PAHs+oxy-PAHs+phenolic compounds oxidation) factors...
April 5, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29620493/winogradskyella-pocilloporae-sp-nov-isolated-from-healthy-tissue-of-the-coral-pocillopora-damicornis
#7
Angel Franco, Hans-Jürgen Busse, Patrick Schubert, Thomas Wilke, Peter Kämpfer, Stefanie P Glaeser
A novel Gram-stain-negative, rod-shaped, strictly aerobic, and orange-yellow pigmented bacterium, designated strain AFPH31T , was isolated from internal tissues of the scleractinian coral Pocillopora damicornis, cultured in a marine aquarium system at the Justus Liebig University Giessen, Germany. Phylogenetic analyses based on 16S rRNA gene sequences placed the strain within the monophyletic cluster of the genus Winogradskyella and showed highest sequence similarity to type strains of the species Winogradskyella eximia (96...
April 5, 2018: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29613787/miuramides-a-and-b-trisoxazole-macrolides-from-a-mycale-sp-marine-sponge-that-induce-a-protrusion-phenotype-in-cultured-mammalian-cells
#8
Rei Suo, Kentaro Takada, Hisanori Kohtsuka, Yuji Ise, Shigeru Okada, Shigeki Matsunaga
Morphology-guided cell-based screening of the extract of a Mycale sp. marine sponge led to the isolation of two trisoxazole macrolides, miuramides A (1) and B (2), which induced characteristic morphological changes in 3Y1 cells. The structure of 1 including absolute configuration was elucidated by a combination of the analysis of spectroscopic data, derivatization, and degradation. Both compounds exhibit potent cytotoxicity against 3Y1 cells.
April 3, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29609542/gastrointestinal-microbial-community-changes-in-atlantic-cod-gadus-morhua-exposed-to-crude-oil
#9
Andrea Bagi, Even Sannes Riiser, Hilde Steine Molland, Bastiaan Star, Thomas H A Haverkamp, Magne Olav Sydnes, Daniela Maria Pampanin
BACKGROUND: The expansion of offshore oil exploration increases the risk of marine species being exposed to oil pollution in currently pristine areas. The adverse effects of oil exposure through toxic properties of polycyclic aromatic hydrocarbons (PAHs) have been well studied in Atlantic cod (Gadus morhua). Nevertheless, the fate of conjugated metabolites in the intestinal tract and their effect on the diversity of intestinal microbial community in fish is less understood. Here, we investigated the intestinal microbial community composition of Atlantic cod after 28 days of exposure to crude oil (concentration range 0...
April 2, 2018: BMC Microbiology
https://www.readbyqxmd.com/read/29606488/discovery-of-new-a-and-b-type-laxaphycins-with-synergistic-anticancer-activity
#10
Weijing Cai, Susan Matthew, Qi-Yin Chen, Valerie J Paul, Hendrik Luesch
Two new cyclic lipopeptides termed laxaphycins B4 (1) and A2 (2) were discovered from a collection of the marine cyanobacterium Hormothamnion enteromorphoides, along with the known compound laxaphycin A. The planar structures were solved based on a combined interpretation of 1D and 2D NMR data and mass spectral data. The absolute configurations of the subunits were determined by chiral LC-MS analysis of the hydrolysates, advanced Marfey's analysis and 1D and 2D ROESY experiments. Consistent with similar findings on other laxaphycin A- and B-type peptides, laxaphycin B4 (1) showed antiproliferative effects against human colon cancer HCT116 cells with IC50 of 1...
March 14, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29605809/success-stories-of-natural-product-based-hybrid-molecules-for-multi-factorial-diseases
#11
REVIEW
Shalki Choudhary, Pankaj Kumar Singh, Himanshu Verma, Harpreet Singh, Om Silakari
Complex diseases comprises of highly complicated etiology resulting in limited applicability of conventional targeted therapies. Consequently, conventional medicinal compounds suffer major failure when used for such disease conditions. Additionally, development of multidrug resistance (MDR), adverse drug reactions and clinical specificity of single targeted drug therapy has increased thrust for novel drug therapy. In this rapidly evolving era, natural product-based discovery of hybrid molecules or multi-targeted drug therapies have shown promising results and are trending now a days...
March 24, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29605644/antialgal-compounds-with-antialgal-activity-against-the-common-red-tide-microalgae-from-a-green-algae-ulva-pertusa
#12
Ying-Ying Sun, Wen-Jing Zhou, Hui Wang, Gan-Lin Guo, Zhen-Xia Su, Yin-Fang Pu
Nine antialgal active compounds, (i.e. trehalose (1), twenty-two methyl carbonate (2), (-)-dihydromenisdaurilide (3), 3,7,11,15-tetramethyl-2-hexadecen-1-ol (4), isophytol (5), 8-hexadecenol (6), 17-hydroxyheptadecanoic acid (7), trans-asarone (8) and 2-amino-3-mercaptopropanoic acid (9)) were isolated from Ulva pertusa for the first time by sephadex LH-20 column chromatography, silica gel column chromatography and repeated preparative TLC. Except for compound 4, all compounds represented novel isolated molecules from marine macroalgae...
March 29, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29600717/secondary-metabolites-from-antarctic-marine-derived-fungus-penicillium-crustosum-hdn153086
#13
Cong-Cong Liu, Zhen-Zhen Zhang, Yan-Yan Feng, Qian-Qun Gu, De-Hai Li, Tian-Jiao Zhu
A new polyene compound (1) and a new diketopiperazine (2), as well as three known compounds (3-5), were isolated from the Antarctic marine-derived fungus Penicillium crustosum HDN153086. The structures of 1-5 were deduced based on MS, NMR and TD-DFT calculations of specific ECD spectra. These compounds were evaluated for their cytotoxic activities against K562 cell line and only compound 2 exhibited cytotoxicity against K562 cell, with IC50 value of 12.7 μM.
March 30, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29597338/dose-response-modelling-of-paralytic-shellfish-poisoning-psp-in-humans
#14
Nathalie Arnich, Anne Thébault
Paralytic shellfish poisoning (PSP) is caused by a group of marine toxins with saxitoxin (STX) as the reference compound. Symptoms in humans after consumption of contaminated shellfish vary from slight neurological and gastrointestinal effects to fatal respiratory paralysis. A systematic review was conducted to identify reported cases of human poisoning associated with the ingestion of shellfish contaminated with paralytic shellfish toxins (PSTs). Raw data were collected from 143 exposed individuals (113 with symptoms, 30 without symptoms) from 13 studies...
March 28, 2018: Toxins
https://www.readbyqxmd.com/read/29582345/absence-of-cellular-damage-in-tropical-newly-hatched-sharks-chiloscyllium-plagiosum-under-ocean-acidification-conditions
#15
Ana Rita Lopes, Eduardo Sampaio, Catarina Santos, Ana Couto, Maria Rita Pegado, Mário Diniz, Philip L Munday, Jodie L Rummer, Rui Rosa
Sharks have maintained a key role in marine food webs for 400 million years and across varying physicochemical contexts, suggesting plasticity to environmental change. In this study, we investigated the biochemical effects of ocean acidification (OA) levels predicted for 2100 (pCO2 ~ 900 μatm) on newly hatched tropical whitespotted bamboo sharks (Chiloscyllium plagiosum). Specifically, we measured lipid, protein, and DNA damage levels, as well as changes in the activity of antioxidant enzymes and non-enzymatic ROS scavengers in juvenile sharks exposed to elevated CO2 for 50 days following hatching...
March 27, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29569838/the-feasibility-study-of-an-in-situ-marine-polysaccharide-based-hydrogel-as-the-vitreous-substitute
#16
Xiaolei Jiang, Yanfei Peng, Chaozhong Yang, Wanshun Liu, Baoqin Han
Although various biopolymers and synthetic compounds have been proposed and tested as the vitreous substitutes, no ideal material has been identified yet. In the present study, we developed an in situ-formed hydrogel by crosslinking hydroxypropyl chitosan (HPCTS) with alginate dialdehyde (ADA). Physical properties of the hydrogel were studied and the cytotoxicity was evaluated using L929 fibroblasts, rabbit corneal endothelial cells and retinal pigment epithelial cells. In a preliminary in vivo study, the hydrogel was employed as vitreous substitute after vitrectomy surgery on rabbits and multiple parameters indicating biosafety and biocompatibility were measured and analyzed postoperatively...
March 23, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29554635/miniaturised-marine-algae-test-with-polycyclic-aromatic-hydrocarbons-comparing-equilibrium-passive-dosing-and-nominal-spiking
#17
Nora Claire Niehus, Carolin Floeter, Henner Hollert, Gesine Witt
In this study the miniaturised Marine Algae Test (mMAT) using passive dosing was developed based on the ISO EN DIN10253 to investigate the growth inhibition of the marine diatom Phaeodactylum tricornutum caused by polycyclic aromatic hydrocarbons (PAHs). Risk assessment of hydrophobic organic compounds (HOCs) like PAHs in aquatic toxicity tests is very difficult due to their low aqueous solubilities, losses via sorption to the wells and volatilisation. However, passive dosing can overcome these challenges. In this study biocompatible silicone O-rings were used as PAH reservoir...
March 9, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29547537/toxins-in-drug-discovery-and-pharmacology
#18
EDITORIAL
Steve Peigneur, Jan Tytgat
Venoms from marine and terrestrial animals (cone snails, scorpions, spiders, snakes, centipedes, cnidarian, etc.) can be seen as an untapped cocktail of biologically active compounds, being increasingly recognized as a new emerging source of peptide-based therapeutics.
March 16, 2018: Toxins
https://www.readbyqxmd.com/read/29532384/characterization-of-phosphate-rock-and-phosphogypsum-from-gabes-phosphate-fertilizer-factories-se-tunisia-high-mining-potential-and-implications-for-environmental-protection
#19
Radhouan El Zrelli, Lotfi Rabaoui, Nabil Daghbouj, Heithem Abda, Sylvie Castet, Claudie Josse, Pieter van Beek, Marc Souhaut, Sylvain Michel, Nejla Bejaoui, Pierre Courjault-Radé
Since the establishment of the coastal industrial complex in Gabes city (Gulf of Gabes, SE Tunisia), hundred million tons of untreated phosphogypsum have been discharged in the open sea causing serious environmental problems. To better understand the dynamic and behavior of phosphate/phosphogypsum contaminants from raw ores to marine environment, a chemical, organic, mineralogical, and morphological characterization of phosphate rock and phosphogypsum was conducted using several sophisticated techniques. The chemical analysis showed that phosphate and phosphogypsum contain high loads of trace elements and that the transfer factors of pollutants varied from 5...
March 12, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29520513/production-and-identification-of-inthomycin-b-produced-by-a-deep-sea-sediment-derived-streptomyces-sp-yb104-based-on-cultivation-dependent-approach
#20
Qihao Wu, Gaiyun Zhang, Bixia Wang, Xin Li, Shaopeng Yue, Jianwei Chen, Huawei Zhang, Hong Wang
The natural products discovery program in our group utilizes deep-sea sediment-derived microorganisms and employs a bio-active guided isolation procedure and one strain many compounds (OSMAC) approach to screen bio-active natural products for practical applications in the medicinal and agricultural industry. OSMAC strategy is employed to stimulate secondary metabolite production through changing culture conditions. In this paper, we applied cultivation-dependent procedure, changing media type, leading to the discovery of a bio-active compound named inthomycin B (1) from a marine-derived Streptomyces sp...
March 8, 2018: Current Microbiology
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