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marine based compounds

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https://www.readbyqxmd.com/read/28528426/building-a-bio-based-industry-in-the-middle-east-through-harnessing-the-potential-of-the-red-sea-biodiversity
#1
REVIEW
Jens Nielsen, John Archer, Magbubah Essack, Vladimir B Bajic, Takashi Gojobori, Ivan Mijakovic
The incentive for developing microbial cell factories for production of fuels and chemicals comes from the ability of microbes to deliver these valuable compounds at a reduced cost and with a smaller environmental impact compared to the analogous chemical synthesis. Another crucial advantage of microbes is their great biological diversity, which offers a much larger "catalog" of molecules than the one obtainable by chemical synthesis. Adaptation to different environments is one of the important drives behind microbial diversity...
May 20, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28527417/fate-of-the-sunscreen-compound-oxybenzone-in-cyperus-alternifolius-based-hydroponic-culture-uptake-biotransformation-and-phytotoxicity
#2
Feiran Chen, Christian Huber, Peter Schröder
Oxybenzone (OBZ), a common ingredient in sunscreens and personal care products, has been frequently detected in effluents from municipal wastewater treatment plants and also in surface waters. OBZ is an emerging contaminant due to its adverse impacts on marine/aquatic ecosystems. To investigate the removal and degradation capacity of phytotreatment for OBZ, the common wetland plant species Cyperus alternifolius L. was exposed to this compound at 5, 25 and 50 μM for 120 h, respectively. Continuous uptake by roots and accumulation in plant tissues was observed over the exposure time, and depletion of spiked OBZ from the aqueous medium exceeded 73...
May 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28509846/a-new-ergosterol-analog-a-new-bis-anthraquinone-and-anti-obesity-activity-of-anthraquinones-from-the-marine-sponge-associated-fungus-talaromyces-stipitatus-kufa-0207
#3
Jidapa Noinart, Suradet Buttachon, Tida Dethoup, Luís Gales, José A Pereira, Ralph Urbatzka, Sara Freitas, Michael Lee, Artur M S Silva, Madalena M M Pinto, Vítor Vasconcelos, Anake Kijjoa
A new ergosterol analog, talarosterone (1) and a new bis-anthraquinone derivative (3) were isolated, together with ten known compounds including palmitic acid, ergosta-4,6,8(14),22-tetraen-3-one, ergosterol-5,8-endoperoxide, cyathisterone (2), emodin (4a), questinol (4b), citreorosein (4c), fallacinol (4d), rheoemodin (4e) and secalonic acid A (5), from the ethyl acetate extract of the culture of the marine sponge-associated fungus Talaromyces stipitatus KUFA 0207. The structures of the new compounds were established based on extensive 1D and 2D spectral analysis, and in the case of talarosterone (1), the absolute configurations of its stereogenic carbons were determined by X-ray crystallographic analysis...
May 16, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28481239/anti-inflammatory-activity-and-structure-activity-relationships-of-brominated-indoles-from-a-marine-mollusc
#4
Tarek B Ahmad, David Rudd, Joshua Smith, Michael Kotiw, Peter Mouatt, Lisa M Seymour, Lei Liu, Kirsten Benkendorff
Marine molluscs are rich in biologically active natural products that provide new potential sources of anti-inflammatory agents. Here we used bioassay guided fractionation of extracts from the muricid Dicathais orbita to identify brominated indoles with anti-inflammatory activity, based on the inhibition of nitric oxide (NO) and tumour necrosis factor α (TNFα) in lipopolysaccharide (LPS) stimulated RAW264.7 macrophages and prostaglandin E2 (PGE2) in calcium ionophore-stimulated 3T3 ccl-92 fibroblasts. Muricid brominated indoles were then compared to a range of synthetic indoles to determine structure-activity relationships...
May 6, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28455852/practical-application-of-in-silico-fragmentation-based-residue-screening-with-ion-mobility-high-resolution-mass-spectrometry
#5
Anton Kaufmann, Patrick Butcher, Kathry Maden, Stephan Walker, Mirjam Widmer
RATIONALE: A screening concept for residues in complex matrices based on liquid chromatography coupled to ion mobility-high resolution mass spectrometry LC-IMS-HRMS is presented. The comprehensive four dimensional data (chromatographic retention time, drift time, mass to charge and ion abundance) obtained in data independent (DIA) acquisition mode was used for data mining. An in silico fragmenter utilizing a molecular structure database was used for suspect screening, instead of targeted screening with reference substances...
April 29, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28454029/aerosol-contributions-at-an-urban-background-site-in-eastern-mediterranean-potential-source-regions-of-pahs-in-pm10-mass
#6
Konstantinos Dimitriou, Pavlos Kassomenos
In this paper, two backward air mass trajectory-based models (Potential Source Contribution Function [PSCF] and Concentration Weighted Trajectory [CWT]) were combined, aiming to identify sources and factors defining the load of PM in the city of Limassol (Cyprus). The study also focused on the determination of atmospheric pathways enriching the aerosol phase of four carcinogenic Polycyclic Aromatic Hydrocarbons (PAHs): Benzo(a)pyrene (BaP), Benzo(a)anthracene (BaA), Benzo(b)fluoranthene (BbF) and Benzo(k)fluoranthene (BkF), in PM10 mass...
April 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28445005/proteomic-based-investigations-on-the-mode-of-action-of-the-marine-anticancer-compound-rhizochalinin
#7
Sergey A Dyshlovoy, Katharina Otte, Simone Venz, Jessica Hauschild, Heike Junker, Tatyana N Makarieva, Stefan Balabanov, Winfried H Alsdorf, Ramin Madanchi, Friedemann Honecker, Carsten Bokemeyer, Valentin A Stonik, Gunhild von Amsberg
Rhizochalinin (Rhiz) is a novel marine natural sphingolipid-like compound which shows promising in vitro and in vivo activity in human castration-resistant prostate cancer (CRPC). In the present study, a global proteome screening approach was applied to investigate molecular targets and biological processes affected by Rhiz in CRPC. Bioinformatical analysis of the data predicted an anti-migratory effect of Rhiz on cancer cells. Validation of proteins involved in the cancer-associated processes, including cell migration and invasion, revealed down-regulation of specific isoforms of stathmin and LASP1, as well as up-regulation of Grp75, keratin 81, and precursor IL-1β by Rhiz...
April 26, 2017: Proteomics
https://www.readbyqxmd.com/read/28441364/indole-derivatives-produced-by-the-metagenome-genes-of-the-escherichia-coli-harboring-marine-sponge-discodermia-calyx
#8
Feng-Lou Liu, Xiao-Long Yang
Three indole derivatives, a novel benzoxazine-indole hybrid (1) and two known indole trimers (2, 3), were isolated from the metagenomic library of the marine sponge Discodermia calyx based on functional screening. Their structures were elucidated by extensive spectroscopic analysis and comparison of their NMR data to that of known compounds. The antibacterial assay indicated that only compound 2 displayed significant antibacterial activity against Bacillus cereus, with approximately 20 mm diameter growth inhibition at 10 µg/paper...
April 25, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28440800/the-trichodesmium-consortium-conserved-heterotrophic-co-occurrence-and-genomic-signatures-of-potential-interactions
#9
Michael D Lee, Nathan G Walworth, Erin L McParland, Fei-Xue Fu, Tracy J Mincer, Naomi M Levine, David A Hutchins, Eric A Webb
The nitrogen (N)-fixing cyanobacterium Trichodesmium is globally distributed in warm, oligotrophic oceans, where it contributes a substantial proportion of new N and fuels primary production. These photoautotrophs form macroscopic colonies that serve as relatively nutrient-rich substrates that are colonized by many other organisms. The nature of these associations may modulate ocean N and carbon (C) cycling, and can offer insights into marine co-evolutionary mechanisms. Here we integrate multiple omics-based and experimental approaches to investigate Trichodesmium-associated bacterial consortia in both laboratory cultures and natural environmental samples...
April 25, 2017: ISME Journal
https://www.readbyqxmd.com/read/28433779/identification-of-new-anti-inflammatory-agents-based-on-nitrosporeusine-natural-products-of-marine-origin
#10
Satish Chandra Philkhana, Abhishek Kumar Verma, Gorakhnath R Jachak, Bibhabasu Hazra, Anirban Basu, D Srinivasa Reddy
Nitrosporeusines A and B are two recently isolated marine natural products with novel skeleton and exceptional biological profile. Interesting antiviral activity of nitrosporeusines and promising potential in curing various diseases, evident from positive data from various animal models, led us to investigate their anti-inflammatory potential. Accordingly, we planned and synthesized nitrosporeusines A and B in racemic as well as enantiopure forms. The natural product synthesis was followed by preparation of several analogues, and all the synthesized compounds were evaluated for in vitro and in vivo anti-inflammatory potential...
April 13, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28430158/identification-of-tight-binding-plasmepsin-ii-and-falcipain-2-inhibitors-in-aqueous-extracts-of-marine-invertebrates-by-the-combination-of-enzymatic-and-interaction-based-assays
#11
Emir Salas-Sarduy, Yasel Guerra, Giovanni Covaleda Cortés, Francesc Xavier Avilés, María A Chávez Planes
Natural products from marine origin constitute a very promising and underexplored source of interesting compounds for modern biotechnological and pharmaceutical industries. However, their evaluation is quite challenging and requires specifically designed assays to reliably identify the compounds of interest in a highly heterogeneous and interfering context. In the present study, we describe a general strategy for the confident identification of tight-binding protease inhibitors in the aqueous extracts of 62 Cuban marine invertebrates, using Plasmodium falciparum hemoglobinases Plasmepsin II and Falcipain 2 as model enzymes...
April 21, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28427570/high-resolution-mass-spectrometry-based-screening-reveals-lipophilic-toxins-in-multiple-trophic-levels-from-the-north-sea
#12
Gabriel Orellana, Lieven Van Meulebroek, Maarten De Rijcke, Colin R Janssen, Lynn Vanhaecke
Lipophilic marine biotoxins, which are mainly produced by small dinoflagellates, are increasingly detected in coastal waters across the globe. As these producers are consumed by zooplankton and shellfish, the toxins are introduced, bioaccumulated and possibly biomagnified throughout marine food chains. Recent research has demonstrated that ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) is an excellent tool to detect marine toxins in algae and seafood. In this study, UHPLC-HRMS was used to screen lipophilic marine biotoxins in organisms from different trophic levels of the Belgian coastal zone ecosystem...
April 2017: Harmful Algae
https://www.readbyqxmd.com/read/28417455/an-efficient-process-for-obtaining-of-prebiotic-oligosaccharides-derived-from-lactulose-using-isomerised-and-purified-whey-permeate
#13
Carlos Sabater, Agustín Olano, Marin Prodanov, Antonia Montilla, Nieves Corzo
BACKGROUND: One of the most promising uses of whey permeate (WP) is the synthesis of prebiotic oligosaccharides. Herein, commercial WP was submitted to chemical isomerisation catalysed by sodium borate at an alkaline pH and subsequent purification using anion-exchange resins to remove boron. Afterwards, purified mixtures were used to synthesise prebiotic oligosaccharides using β-galactosidase from Bacillus circulans. RESULTS: Isomerisation of concentrated WP (200 g L(-1) lactose) gave rise to levels of lactulose up to 155...
April 18, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28406457/new-cytotoxic-secondary-metabolites-from-marine-bryozoan-cryptosula-pallasiana
#14
Xiang-Rong Tian, Yan-Qing Gao, Xiao-Lin Tian, Jiao Li, Hai-Feng Tang, Yu-Shan Li, Hou-Wen Lin, Zhi-Qing Ma
A new sterol, (23R)-methoxycholest-5,24-dien-3β-ol (1), two new ceramides, (2S,3R,4E,8E)-2-(tetradecanoylamino)-4,8-octadecadien-l,3-diol (6) and (2S,3R,2'R,4E,8E)-2-(tetradecanoylamino)-4,8-octadecadien-l,3,2'-triol (7), together with three known sterols (2-4), a lactone (5) and two ceramides (8,9), were isolated from the marine bryozoan Cryptosula pallasiana, collected at Huang Island of China. The structures of the new compounds were elucidated by extensive spectroscopic analyses, chemical methods and quantum electronic circular dichroism (ECD) calculations...
April 13, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28391692/customized-consensus-spectral-library-building-for-untargeted-quantitative-metabolomics-analysis-with-data-independent-acquisition-mass-spectrometry-and-metabodia-workflow
#15
Gengbo Chen, Scott Walmsley, Gemmy C M Cheung, Liyan Chen, Ching-Yu Cheng, Roger W Beuerman, Tien Yin Wong, Lei Zhou, Hyungwon Choi
Data independent acquisition-mass spectrometry (DIA-MS) coupled with liquid chromatography is a promising approach for rapid, automatic sampling of MS/MS data in untargeted metabolomics. However, wide isolation windows in DIA-MS generate MS/MS spectra containing a mixed population of fragment ions together with their precursor ions. This precursor-fragment ion map in a comprehensive MS/MS spectral library is crucial for relative quantification of fragment ions uniquely representative of each precursor ion. However, existing reference libraries are not sufficient for this purpose since the fragmentation patterns of small molecules can vary in different instrument setups...
April 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28387506/interaction-of-azole-based-environmental-pollutants-with-the-coelomic-hemoglobin-from-amphitrite-ornata-a-molecular-basis-for-toxicity
#16
Nikolette L McCombs, Tadeo Moreno-Chicano, Leiah M Carey, Stefan Franzen, Michael A Hough, Reza A Ghiladi
The toxicities of azole pollutants that have widespread agricultural and industrial uses are either poorly understood or unknown, particularly with respect to how infaunal organisms are impacted by this class of persistent organic pollutant. To identify a molecular basis by which azole compounds may have unforeseen toxicity on marine annelids, we examine here their impact on the multifunctional dehaloperoxidase (DHP) hemoglobin from the terebellid polychaete Amphitrite ornata. Ultraviolet-visible and resonance Raman spectroscopic studies showed an increase in the six-coordinate low-spin heme population in DHP isoenzyme B upon binding of imidazole, benzotriazole, and benzimidazole (Kd values of 52, 82, and 110 μM, respectively), suggestive of their direct binding to the heme-Fe...
April 19, 2017: Biochemistry
https://www.readbyqxmd.com/read/28379015/tricyclic-sesquiterpenes-from-marine-origin
#17
Franck Le Bideau, Mohammad Kousara, Li Chen, Lai Wei, Françoise Dumas
The structure elucidation, biosynthesis, and biological activity of marine carbotricyclic sesquiterpene compounds are reviewed from the pioneering results to the end of 2015. Their total syntheses with a particular emphasis on the first syntheses, enantiomeric versions, and syntheses that led to the revision of structures or stereochemistries are summarized. Overall, 284 tricyclic compounds are classified into fused, bridged, and miscellaneous structures based on 54 different skeletal types. Tricyclic sesquiterpenes constitute an important group of natural products...
April 5, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28377212/differentiating-true-androgen-receptor-inhibition-from-cytotoxicity-mediated-reduction-of-reporter-gene-transactivation-in-vitro
#18
Maricel Marin-Kuan, Karma C Fussell, Nicolas Riederer, Helia Latado, Patrick Serrant, Julie Mollergues, Myriam Coulet, Benoit Schilter
In vitro effect-based reporter assays are applied as biodetection tools designed to address nuclear receptor mediated-modulation. While such assays detect receptor modulating potential, cell viability needs to be addressed, preferably in the same well. Some assays circumvent this by co-transfecting a second constitutively-expressed marker gene or by multiplexing a cytotoxicity assay. Some assays, such as the CALUX®, lack this feature. The cytotoxic effects of unknown substances can confound in vitro assays, making the interpretation of results difficult and uncertain, particularly when assessing antagonistic activity...
April 1, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28370791/cyanobacterial-ent-sterol-like-natural-products-from-a-deviated-ubiquinone-pathway
#19
Philipp Moosmann, Reiko Ueoka, Laura Grauso, Alfonso Mangoni, Brandon I Morinaka, Muriel Gugger, Jörn Piel
Natural products from marine animals show high potential for the development of new medicines, but drug development based on these compounds is commonly hampered by their low natural abundance. Since many of these metabolites are suspected or known to be produced by uncultivated bacterial symbionts, the rapidly growing diversity of sequenced prokaryotic genomes offers the opportunity to identify alternative, culturable sources of natural products computationally. In this work, we investigated the potential of using this sequenced resource to facilitate the production of meroterpenoid-like compounds related to those from marine sources...
March 30, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28364227/an-anti-mycobacterial-bisfunctionalized-sphingolipid-and-new-bromopyrrole-alkaloid-from-the-indonesian-marine-sponge-agelas-sp
#20
Delfly B Abdjul, Hiroyuki Yamazaki, Syu-Ichi Kanno, Ayako Tomizawa, Henki Rotinsulu, Defny S Wewengkang, Deiske A Sumilat, Kazuyo Ukai, Magie M Kapojos, Michio Namikoshi
In the course of our studies on anti-mycobacterial substances from marine organisms, the known dimeric sphingolipid, leucettamol A (1), was isolated as an active component, together with the new bromopyrrole alkaloid, 5-bromophakelline (2), and twelve known congeners from the Indonesian marine sponge Agelas sp. The structure of 2 was elucidated based on its spectroscopic data. Compound 1 and its bis TFA salt showed inhibition zones of 12 and 7 mm against Mycobacterium smegmatis at 50 μg/disk, respectively, while the N,N'-diacetyl derivative (1a) was not active at 50 μg/disk...
March 31, 2017: Journal of Natural Medicines
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