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sentinel node in endometrial cancer

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https://www.readbyqxmd.com/read/29146390/laparoendoscopic-single-site-less-sentinel-lymph-node-sln-detection-in-endometrial-cancer-ec
#1
Gökhan Demirayak, Cihan Comba, İsa Aykut Özdemir
No abstract text is available yet for this article.
November 13, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29121779/image-guided-surgery-in-gynecologic-oncology
#2
Henri Azaïs, Geoffroy Canlorbe, Yohan Kerbage, Anne Grabarz, Pierre Collinet, Serge Mordon
Image-guided surgery is a relevant way to reduce surgical morbidity and maximize cytoreductive surgery approach especially in ovarian cancer. Sentinel lymph node detection is a promising approach to avoid radical lymph node dissection and is slightly becoming standard in daily practice in endometrial and cervical cancer surgery even if it needs to be evaluated more precisely. Regarding carcinomatosis of ovarian origin, detection and treatment of microscopic disease could be appropriate to avoid local recurrences...
November 10, 2017: Future Oncology
https://www.readbyqxmd.com/read/29098518/the-detection-of-sentinel-lymph-nodes-in-laparoscopic-surgery-can-eliminate-systemic-lymphadenectomy-for-patients-with-early-stage-endometrial-cancer
#3
Tomohito Tanaka, Yoshito Terai, Satoe Fujiwara, Yoshimichi Tanaka, Hiroshi Sasaki, Satoshi Tsunetoh, Kazuhiro Yamamoto, Takashi Yamada, Masahide Ohmichi
BACKGROUND: The examination of a sentinel lymph node (SLN), where lymph node metastasis first occurs, may be advocated as an alternative staging technique. The aim of this study was to evaluate the feasibility and detection rates of an SLN biopsy in patients with endometrial cancer. STUDY DESIGN: Two hundred and eleven patients with endometrial cancer underwent an SLN biopsy at hysterectomy using three kinds of tracers including 99m-technetium-labeled tin colloid ((99m)Tc), indigo carmine and indocyanine green...
November 2, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29058141/the-impact-of-sentinel-node-mapping-in-staging-high-risk-endometrial-cancer
#4
Glauco Baiocchi, Henrique Mantoan, Lillian Yuri Kumagai, Bruna Tirapelli Gonçalves, Levon Badiglian-Filho, Ademir Narciso de Oliveira Menezes, Carlos Chaves Faloppa, Louise De Brot, Alexandre Andre Balieiro Anastacio da Costa
BACKGROUND: This study aimed to determine the impact of sentinel lymph node (SLN)-mapping on the staging of high-risk endometrial cancer (endometrioid grade 3, serous, clear cell, carcinosarcoma, deep myometrial invasion, or angiolymphatic invasion). METHODS: The study analyzed a series of 236 patients treated at AC Camargo Cancer Center from June 2007 to February 2017. The compared 75 patients who underwent SLN-mapping (SLN group) with 161 patients who received pelvic ± para-aortic lymphadenectomy (N-SLN group)...
October 20, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29056441/use-of-a-novel-sentinel-lymph-node-mapping-algorithm-reduces-the-need-for-pelvic-lymphadenectomy-in-low-grade-endometrial-cancer
#5
Edward Tanner, Allison Puechl, Kimberly Levinson, Laura J Havrilesky, Abdulrahman Sinno, Angeles Alvarez Secord, Amanda N Fader, Paula S Lee
OBJECTIVES: To evaluate the capability of a novel sentinel lymph node (SLN) mapping algorithm to reduce the need for pelvic lymphadenectomy (PLND) in patients with low-grade (G1-2) endometrial cancer (LGEC). METHODS: Patients with LGEC underwent evaluation according to a novel lymphatic assessment algorithm during hysterectomy with SLN biopsy at two academic gynecologic oncology programs. Side-specific PLND was only performed if ipsilateral SLN mapping failed and high-risk uterine features were identified on frozen section (FS)...
October 19, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29038041/minilaparoscopy-vs-standard-laparoscopy-for-sentinel-node-dissection-a-pilot-study
#6
Stefano Uccella, Alessandro Buda, Chiara Morosi, Giampaolo Di Martino, Martina Delle Marchette, Claudio Reato, Jvan Casarin, Fabio Ghezzi
OBJECTIVE: To compare 3-mm minilaparoscopy and standard 5-mm laparoscopy for sentinel node (SLN) detection in apparent early stage endometrial cancer (EC). DESIGN: Retrospective study (Canadian Task Force II-2). SETTING: Two academic research centers. PATIENTS: Consecutive women with apparent early stage EC, who underwent surgical staging with SLN between November 2015 and April 2016. INTERVENTIONS: Total laparoscopic extrafascial hysterectomy + bilateral salpingo-oophorectomy and SLN attempt...
October 13, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29032824/the-impact-on-survival-of-two-different-staging-strategies-in-apparent-early-stage-endometrial-cancer-comparing-sentinel-lymph-nodes-mapping-algorithm-and-selective-lymphadenectomy-an-italian-retrospective-analysis-of-two-reference-centers
#7
Alessandro Buda, Giampaolo Di Martino, Stefano Restaino, Elena De Ponti, Giorgia Monterossi, Daniela Giuliani, Alfredo Ercoli, Federica Dell'Orto, Giorgia Dinoi, Tommaso Grassi, Giovanni Scambia, Francesco Fanfani
OBJECTIVE: The role of lymphadenectomy in endometrial cancer is still uncertain. We aimed to evaluate the survival outcomes of two different strategies in apparent uterine confined disease by comparing sentinel lymph node (SLN) mapping and selective lymphadenectomy (LD). METHODS: We retrospectively reviewed women with preoperative stage I endometrial cancer underwent surgical staging with either SLN mapping, or LD in two Italian centers. RESULTS: Eight hundred and two women underwent surgical staging for preoperative stage I endometrial cancer were revised (145 Monza; 657 Rome)...
October 9, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28968296/sentinel-lymph-node-ultra-staging-as-a-supplement-for-endometrial-cancer-intraoperative-frozen-section-deficiencies
#8
Morgan Blakely, Yuxin Liu, Jamal Rahaman, Monica Prasad-Hayes, Mikhail Tismenetsky, Xiaofei Wang, Navya Nair, Karen A Dresser, Nimesh Nagarsheth, Tamara Kalir
For endometrial cancer (EC), most surgeons rely on intraoperative frozen section (IFS) to determine the risk of nodal metastasis and necessity of lymphadenectomy. IFS remains a weak link in this practice due to its susceptibility to diagnostic errors. As a less invasive alternative, sentinel lymph node (SLN) mapping and ultra-staging have gradually gained acceptance for EC. We aimed to establish the SLN success rate, negative predictive value, and whether SLNs provide useful information for cases misdiagnosed on IFS...
September 29, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28965698/comparison-of-a-sentinel-lymph-node-mapping-algorithm-and-comprehensive-lymphadenectomy-in-the-detection-of-stage-iiic-endometrial-carcinoma-at-higher-risk-for-nodal-disease
#9
Jennifer A Ducie, Ane Gerda Zahl Eriksson, Narisha Ali, Michaela E McGree, Amy L Weaver, Giorgio Bogani, William A Cliby, Sean C Dowdy, Jamie N Bakkum-Gamez, Robert A Soslow, Gary L Keeney, Nadeem R Abu-Rustum, Andrea Mariani, Mario M Leitao
OBJECTIVE: To determine if a sentinel lymph node (SLN) mapping algorithm will detect metastatic nodal disease in patients with intermediate-/high-risk endometrial carcinoma. METHODS: Patients were identified and surgically staged at two collaborating institutions. The historical cohort (2004-2008) at one institution included patients undergoing complete pelvic and paraaortic lymphadenectomy to the renal veins (LND cohort). At the second institution an SLN mapping algorithm, including pathologic ultra-staging, was performed (2006-2013) (SLN cohort)...
September 28, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28954449/-clinical-analysis-of-76-cases-of-sentinel-lymph-node-detection-in-cervical-cancer-and-endometrial-cancer
#10
S C Liang, Z Q Wang, J L Wang
Objective: To evaluate the feasibility and clinical value of identifying sentinel lymph node (SLN) and to assess possible factors associated with detection rate in both cervical cancer and endometrial cancer. Methods: Retrospective study of 76 cases (39 with cervical cancer and 37 with endometrial cancer) were conducted in Peking University People's Hospital. All patients underwent SLN biopsy with tracers of indocyanine green (ICG) and (or) carbon nanoparticles. All mapped SLN was resected and followed by procedures that systematic pelvic lymphadenectomy and hysterectomy according to National Comprehensive Cancer Network (NCCN) guidelines...
September 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28942993/performance-of-sentinel-lymph-node-sln-mapping-in-high-risk-endometrial-cancer
#11
Omar Touhami, Jean Grégoire, Marie-Claude Renaud, Alexandra Sebastianelli, Marie Plante
OBJECTIVE: While the accuracy of the SLN procedure has been validated in patients with low risk EC, its relevance for high-risk EC remains debated. The aim of this study was to evaluate the accuracy of SLN mapping in patients with high-risk EC. STUDY METHOD: We reviewed all patients with high risk EC (grade 3 endometrioid, serous, carcinosarcoma, clear cell and undifferentiated) who underwent primary surgery with SLN mapping followed by pelvic +/- paraaortic lymphadenectomy, between November 2010 and November 2016...
September 21, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28939481/laparoscopic-typical-and-atypical-locations-of-sentinel-node-mapping-with-indocyanine-green-comparison-of-2-near-infrared-fluorescence-systems
#12
Giampaolo Di Martino, Claudio Reato, Debora Verri, Federica Dell'Orto, Alessandro Buda
STUDY OBJECTIVE: To present our minimally invasive laparoscopic approach for sentinel lymph node (SLN) mapping with indocyanine green (ICG) using 2 fluorescence systems. DESIGN: A step-by-step video description of the technique showing the most frequent typical and atypical location of SLNs (educational video). SETTING: Lymph node staging in apparent confined endometrial cancer. PATIENTS: Women underwent SLN mapping in a minimally invasive setting...
September 20, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28921419/sentinel-lymph-node-biopsy-in-endometrial-cancer-a-new-standard-of-care
#13
REVIEW
Stephanie A Sullivan, Emma C Rossi
Lymph node status is one of the most important factors in determining prognosis and the need for adjuvant treatment in endometrial cancer (EMCA). Unfortunately, full lymphadenectomy bears significant surgical and postoperative risks. The majority of patients with clinical stage I disease will not have metastatic disease; thus, a full lymphadenectomy only increases morbidity in this population of patients. The use of the sentinel lymph node (SLN) biopsy has emerged as an alternative to complete lymphadenectomy in EMCA...
September 18, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28919095/laparoscopic-near-infrared-fluorescent-imaging-as-an-alternative-option-for-sentinel-lymph-node-mapping-in-endometrial-cancer-a-prospective-study
#14
Salih Taşkın, Yavuz Emre Şükür, Duygu Altın, Cevriye Cansız Ersöz, Batuhan Turgay, Duygu Kankaya, Mete Güngör, Fırat Ortaç
BACKGROUND: To evaluate feasibility of sentinel lymph node (SLN) mapping by using near-infrared fluorescent imaging and indocyanine green (NIR/ICG) integrated laparoscopic system in clinically uterine-confined endometrial cancer. MATERIALS AND METHODS: Patients with clinically early-stage endometrial cancer were included in this prospective study. ICG was injected to the uterine cervix and NIR/ICG integrated laparoscopic system (Spies Full HD D-Light P ICG technology, Karl Storz, Tuttlingen, Germany) was used during the operations...
November 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28828528/sentinel-lymph-node-mapping-in-endometrial-cancer-comparison-of-fluorescence-dye-with-traditional-radiocolloid-and-blue
#15
REVIEW
Andrea Papadia, Maria Luisa Gasparri, Alessandro Buda, Michael D Mueller
Sentinel lymph node (SLN) mapping in endometrial cancer (EMCA) is rapidly gaining acceptance in the clinical community. As compared to a full lymphadenectomy in every patient, to a selective lymphadenectomy after frozen section of uterus in selected patients with intrauterine risk factors or to a strategy in which a lymphadenectomy is always omitted, SLN mapping seems to be a reasonable and oncologically safe middle ground. Various protocols can be used when applying an SLN mapping. In this manuscript we review the characteristics, toxicity and clinical impact of technetium-99m radiocolloid (Tc-99m), of the blue dyes (methylene blue, isosulfan blue and patent blue) and of indocyanine green (ICG)...
August 21, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28807805/laparoscopic-sentinel-node-mapping-in-cervical-and-endometrial-malignancies-a-case-control-study-comparing-two-near-infrared-fluorescence-systems
#16
Alessandro Buda, Giampaolo Di Martino, Elena De Ponti, Paolo Passoni, Federica Sina, Claudio Reato, Francesca Vecchione, Daniela Giuliani
STUDY OBJECTIVE: The goal of this study was to evaluate the intraoperative and perioperative surgical outcomes of 2 different florescence systems commonly used for sentinel lymph node (SLN) mapping in women with early-stage cervical cancer or endometrial cancer. DESIGN: Case-control study (Canadian Task Force classification II-2). SETTING: The Gynecology Oncology Surgical Unit of the San Gerardo Hospital, Italy. PATIENTS: Thirty-four consecutive women with early stage-cervical cancer (stage IA-1B1) or apparent confined stage I endometrial cancer were included in the study...
August 12, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28751118/description-of-a-reproducible-anatomically-based-surgical-algorithm-for-detection-of-pelvic-sentinel-lymph-nodes-in-endometrial-cancer
#17
Jan Persson, Barbara Geppert, Céline Lönnerfors, Michele Bollino, Anna Måsbäck
OBJECTIVE: To describe and evaluate a reproducible, anatomically based surgical algorithm, including reinjection of tracer to enhance technical success rate, for detection of pelvic sentinel lymph nodes (SLNs) in endometrial cancer (EC). METHODS: A prospective study of 102 consecutive women with high risk EC scheduled for robotic surgery was conducted. Following cervical injection of a fluorescent dye, an algorithm for trans- and retroperitoneal identification of tracer display in the lower and upper paracervical pathways was strictly adhered to...
October 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28741261/hereditary-breast-cancer-associated-with-cowden-syndrome-related-pten-mutation-with-lhermitte-duclos-disease
#18
Fuyo Kimura, Ai Ueda, Eiichi Sato, Jiro Akimoto, Hiroshi Kaise, Kimito Yamada, Mari Hosonaga, Yuko Kawai, Saeko Teraoka, Miki Okazaki, Takashi Ishikawa
BACKGROUND: Cowden syndrome is characterized by multiple hamartomas in various tissues, including the skin, brain, breast, thyroid, mucous membrane, and gastrointestinal tract, and is reported to increase the risk of malignant disease. CASE PRESENTATION: We describe the case of a 52-year-old woman in whom a tumor was diagnosed in the left cerebellar hemisphere and treated by surgical resection. Phosphatase and tensin homolog (PTEN) mutation in exon 8 insertion was found in the brain tumor tissue and leukocytes...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28716308/unexpected-locations-of-sentinel-lymph-nodes-in-endometrial-cancer
#19
Jeffrey How, Irina Boldeanu, Susie Lau, Shannon Salvador, Emily How, Raphael Gotlieb, Jeremie Abitbol, Ajay Halder, Zainab Amajoud, Stephan Probst, Sonya Brin, Walter Gotlieb
INTRODUCTION: To evaluate the anatomical location of sentinel lymph nodes (SLN) following intra-operative cervical injection in endometrial cancer. METHODS: All consecutive patients with endometrial cancer undergoing sentinel lymph node mapping were included in this prospective study following intra-operative cervical injection of tracers. Areas of SLN detection distribution were mapped. RESULTS: Among 436 patients undergoing SLN mapping, there were 1095 SLNs removed, and 7...
October 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28629611/sentinel-lymph-node-mapping-in-minimally-invasive-surgery-role-of-imaging-with-color-segmented-fluorescence-csf
#20
Maite I Lopez Labrousse, Michael Frumovitz, M Guadalupe Patrono, Pedro T Ramirez
OBJECTIVE: Sentinel lymph node mapping, alone or in combination with pelvic lymphadenectomy, is considered a standard approach in staging of patients with cervical or endometrial cancer [1-3]. The goal of this video is to demonstrate the use of indocyanine green (ICG) and color-segmented fluorescence when performing lymphatic mapping in patients with gynecologic malignancies. METHODS: Injection of ICG is performed in two cervical sites using 1mL (0.5mL superficial and deep, respectively) at the 3 and 9 o'clock position...
September 2017: Gynecologic Oncology
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