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sentinel node in endometrial cancer

S F Lax, K F Tamussino, P F Lang
Malignancies of the uterus metastasize by direct invasion of neighboring structures, lymphatically or hematogenously. Endometrial and cervical cancers lymphatically spread to the pelvic and para-aortic lymph nodes. For endometrial cancer the depth of myometrial invasion, lymphosvascular space involvement (LVSI) and a microcystic, elongated and fragmented (MELF) glandular invasion pattern are predictors for lymph node metastases. Metastases to the pelvic lymph nodes occur in approximately 10 % of endometrial cancer patients and in 30 % of these cases the para-aortic lymph nodes are also involved...
October 18, 2016: Der Pathologe
Anabela Rocha, Ana Maria Domínguez, Fabrice Lécuru, Nicolas Bourdel
OBJECTIVE: Sentinel lymph node (SLN) mapping for endometrial (EC) and cervical cancers (CC) is a current technique that could provide benefits over traditional lymphadenectomy. Near-infrared (NIR) fluorescence imaging is a promising technique to perform this procedure. We conducted a systematic review of the evidence regarding the technique and the effectiveness of indocyanine green (ICG) during SLN biopsy, using robotic and laparoscopic assisted surgery and laparotomy. MATERIALS AND METHODS: We conducted a computer literature search for published English language studies in humans using PubMed since January 2010 up to May 2015...
September 30, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Samine Sahbai, Florin-Andrei Taran, Francesco Fiz, Annette Staebler, Sven Becker, Erich Solomayer, Diethelm Wallwiener, Christian la Fougère, Sara Brucker, Helmut Dittmann
PURPOSE: Scintigraphic mapping of sentinel lymph node (SLN) is increasingly performed in patients with endometrial carcinoma although its routine clinical use is still under investigation. The purpose of this study was to compare preoperative SLN detection by means of SPECT/CT using pericervical (PC) versus hysteroscopic peritumoral (PT) injection. PATIENTS AND METHODS: One hundred forty consecutive patients with endometrial carcinoma who underwent surgery and preoperative SLN SPECT/CT with Tc-nanocolloid were included...
October 5, 2016: Clinical Nuclear Medicine
Eric Leblanc, Fabrice Narducci, Lucie Bresson, Delphine Hudry
OBJECTIVE: To explore the feasibility of an oncologically acceptable management for an intermediate-risk endometrial cancer (EC) in an elderly, using the combination of transvaginal single-port laparoscopy and sentinel node policy. METHODS: For this 85-years old patient, BMI 32kg/m(2), with IB grade 2 endometrioid EC, a single vaginal approach was attempted [1] to perform a total hysterectomy, bilateral salpinago-oophorectomy and pelvic node assessment guided by SND [2]...
October 13, 2016: Gynecologic Oncology
Angela Collarino, Sergi Vidal-Sicart, Germano Perotti, Renato A Valdés Olmos
This review discusses the state-of-the-art of sentinel lymph node mapping in gynaecological malignancies, including cervical cancer, endometrial cancer, and vulvar cancer, with an emphasis on new technological advances. For this objective, PubMed/MEDLINE was searched for relevant studies about the sentinel lymph node procedure in gynaecology. In particular, the use of preoperative lymphatic mapping with lymphoscintigraphy and single photon emission tomography/computed tomography (SPECT/CT) was identified in 18 studies...
2016: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
Stephanie C J M Speth, Roy F P M Kruitwagen, Marjolein Kleppe, Ivo N A Pooters, Toon Van Gorp, Brigitte F M Slangen, Boudewijn Brans
PURPOSE: Tracer injection into ovarian ligaments has been shown to detect sentinel nodes (SNs) in patients with ovarian cancer. To determine the possibility that SNs are missed, this feasibility study compared their detection during surgery with postoperative SPECT/CT. METHODS: In eight patients (either ovarian or endometrial cancer), after a staging lymphadenectomy including resection of SNs related to the ovary, SPECT/CT scans were performed within 24 hours. RESULTS: SPECT/CT identified hotspots in four patients at sites where SNs were resected...
October 13, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Fabio Martinelli, Antonino Ditto, Giorgio Bogani, Mauro Signorelli, Valentina Chiappa, Domenica Lorusso, Edward Haeusler, Francesco Raspagliesi
STUDY OBJECTIVE: To report on detection-rate (DR) of sentinel-nodes (SLNs) in endometrial-cancer (EC) patients after hysteroscopic injection of indocyanine-green (ICG) and Laparoscopic near-infrared (L-NIR) fluorescence mapping. DESIGN: Prospectively collected data. DESIGN: classification: Canadian Task Force II-2 SETTING: Gynecologic oncology referral center. PATIENTS: Consecutive patients with apparent early-stage endometrioid EC scheduled for surgical treatment: total-laparoscopic-hysterectomy, bilateral salpingo-oophorectomy, SLNs mapping...
October 7, 2016: Journal of Minimally Invasive Gynecology
F Martinelli, A Ditto, G Bogani, V Chiappa, D Lorusso, F Raspagliesi
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
C-H Chen, H-H Chen, W-M Liu
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
Alessandro Buda, Paolo Passoni, Giacomo Corrado, Beatrice Bussi, Giuseppe Cutillo, Sonia Magni, Enrico Vizza
Sentinel lymph node (SLN) mapping has increased its feasibility in both early stage cervical and endometrial cancer. There are few SLN studies regarding the ovary, because of the risk of tumor dissemination and perhaps because the ovary represents an inconvenient site for injection. In this preliminary study, we have shown the feasibility of SLN mapping of the ovary with Indocyanine green (ICG) during laparoscopic retroperitoneal aortic surgical staging. The ten women who were included in this study underwent aortic with pelvic laparoscopic staging, which included SLN biopsy, extrafascial total hysterectomy and bilateral salpingo-oophorectomy in case of ovarian tumor...
September 23, 2016: Journal of Minimally Invasive Gynecology
M Mayoral, P Paredes, B Domènech, P Fusté, S Vidal-Sicart, A Tapias, A Torné, J Pahisa, J Ordi, F Pons, F Lomeña
OBJECTIVE: Definitive staging for cervical (CC) and endometrial cancer (EC) takes place once surgery is performed. The aim of this study was to evaluate the role of PET/CT in detecting lymphatic metastasis in patients with CC and EC using dual-time-point imaging (DPI), taking the histopathological results of sentinel lymph node (SLN) and lymphadenectomy as the reference. MATERIAL AND METHODS: A prospective study was conducted on 17 patients with early CC, and 13 patients with high-risk EC...
September 22, 2016: Revista Española de Medicina Nuclear e Imagen Molecular
Tugan Bese, Veysel Sal, Fuat Demirkiran, Ilker Kahramanoglu, Nedim Tokgozoglu, Sennur Ilvan, Ovgu Aydin, Metin Hallac, Betul Vatankulu, Gokhan Demirayak, Hasan Turan, Macit Arvas
OBJECTIVE: The goal of this study was to evaluate the combination of sentinel lymph node (SLN) mapping and F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) scan in detection of lymph node involvement in patients with endometrioid endometrial cancer (EEC). METHODS/MATERIALS: Ninety-five patients with EEC who had preoperative PET/CT imaging and underwent SLN mapping were retrospectively analyzed. Methylene blue dye was used and injected to the cervix at 3- and 9-o'clock positions (a total of 4 mL)...
September 2016: International Journal of Gynecological Cancer
Abdulrahman K Sinno, Elizabeth Peijnenburg, Amanda N Fader, Sarah M Temkin, Rebecca Stone, Kimberly Levinson, Tricia Murdock, Edward J Tanner
OBJECTIVES: To compare the utility of three lymph node (LN) assessment strategies to identify lymphatic metastases while minimizing complete lymphadenectomy rates in women with low-grade endometrial cancer (EC). METHODS: Using our institutional standard protocol (SP), patients with complex atypical hyperplasia (CAH) or grade 1/2 EC underwent sentinel lymph node (SLN) mapping, hysterectomy, and intraoperative frozen section (FS). Lymphadenectomy was performed if high-risk uterine features were identified on FS...
August 24, 2016: Gynecologic Oncology
Lorna A Brudie, Faizan Khan, Michael J Radi, Sarfraz Ahmad
Endometrial serous carcinomas are very clinically aggressive, which constitutes 40% of all deaths and recurrences associated with endometrial cancer. Small-cell carcinoma of the endometrium is relatively rare but aggressive, and often presents a component of endometrioid carcinoma, and is not generally associated with serous carcinoma. Herein, we report a case of 74-year-old African-American female, who presented with intermittent post-menopausal bleeding for > 1-month. She underwent robotic-assisted laparoscopic hysterectomy, bilateral salpingo-oophorectomy, sentinel lymph node mapping, and pelvic-and-aortic lymphadenectomy...
August 2016: Gynecologic Oncology Reports
María E López-Ruiz, María D Diestro, Laura Yébenes, Alberto Berjón, Begoña Díaz de la Noval, Marta Mendiola, Javier De Santiago, David Hardisson
OBJECTIVE: To evaluate the efficacy of one-step nucleic acid amplification (OSNA) for the diagnosis of sentinel lymph node (SLN) metastasis compared with histopathological examination in patients with endometrial carcinoma. METHODS: A total of 94 SLNs from 34 patients with endometrial carcinoma were enrolled. The central 1-mm portion of each node was subjected to semi-serial sectioning, sliced at 200-μm intervals and examined by hematoxylin and eosin and cytokeratin 19 (CK19) immunohistochemical staining, and the remaining tissue was analysed by OSNA using CK19 mRNA...
October 2016: Gynecologic Oncology
Jessie Ehrisman, Angeles Alvarez Secord, Andrew Berchuck, Paula S Lee, Nicola Di Santo, Micael Lopez-Acevedo, Gloria Broadwater, Fidel A Valea, Laura J Havrilesky
OBJECTIVE: To determine the rate and performance of sentinel lymph node (SLN) mapping among women with high-risk endometrial cancers. METHODS: Patients diagnosed between 2012 and 2015 with uterine cancer of grade 3 endometrioid, clear cell, serous or carcinosarcoma histology and who underwent SLN mapping prior to full pelvic lymph node dissection were included. Subjects underwent methylene blue or ICG injection for laparoscopic (N = 16) or robotic-assisted laparoscopic (N = 20) staging...
August 2016: Gynecologic Oncology Reports
Andrea Papadia, Sara Imboden, Maria Luisa Gasparri, Franziska Siegenthaler, Anja Fink, Michael D Mueller
PURPOSE: The adoption of a sentinel lymph node (SLN) algorithm and the presence of high bilateral detection rates have been associated with increased accuracy of SLN mapping in cervical and endometrial cancer patients. In this context, the significance of the number of SLNs removed has not yet been investigated. The aim of this study was to evaluate (a) whether or not a higher SLN removal count is associated with a reduced false-negative rate and (b) which clinical factors correlate with the number of SLNs removed...
August 2016: Journal of Cancer Research and Clinical Oncology
Leslie H Clark, John T Soper
IMPORTANCE: The role of lymph node dissection in early-stage endometrial cancer is highly debated, but staging and prognosis are dependent on knowledge of lymph node metastasis. OBJECTIVE: We sought to review the available data on the use of lymph node assessment in presumed early-stage endometrial cancer. EVIDENCE ACQUISITION: A comprehensive literature review was performed using MEDLINE, the Cochrane Collaborative Database, and PubMed. RESULTS: There is limited retrospective data that suggest a therapeutic benefit to lymphadenectomy...
June 2016: Obstetrical & Gynecological Survey
Roi Tschernichovsky, Elisabeth J Diver, John O Schorge, Annekathryn Goodman
OBJECTIVE: The objective of this study is to review existing data regarding the feasibility, diagnostic performance, and oncologic outcomes of sentinel lymph node biopsy (SLNB) versus lymphadenectomy (LND) in endometrial cancer. MATERIALS AND METHODS: A PubMed search identified studies on different staging strategies in endometrial cancer, including routine LND, predictive models of selective nodal dissection, and SLNB. RESULTS: There is ongoing controversy over the risk-benefit ratio of LND in assessing nodal involvement in presumed early-stage endometrial cancer...
October 2016: American Journal of Clinical Oncology
Maki Nakai, Hiroyuki Takei, Keiko Yanagihara, Koji Yamashita, Eiji Uchida
Although the use of endocrine therapy in combination with intravenous chemotherapy has not been standardized, the combination of fulvestrant and chemotherapy may be promising. A 62-year-old woman came to our hospital's outpatient clinic with extensive ascites. Approximately 10 years earlier, she had undergone mastectomy and sentinel lymph node biopsy. Pathologically invasive lobular carcinoma, with a maximum diameter of 28 mm, had been diagnosed in the left breast. The cancer had a histological grade of 2, was positive for estrogen receptor (95% or more positive cells), and was negative for both progesterone receptor (less than 1% positive cells) and human epidermal growth factor receptor 2...
2016: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
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