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https://www.readbyqxmd.com/read/28334915/salience-and-default-mode-network-dysregulation-in-chronic-cocaine-users-predict-treatment-outcome
#1
Xiujuan Geng, Yuzheng Hu, Hong Gu, Betty Jo Salmeron, Bryon Adinoff, Elliot A Stein, Yihong Yang
While chronic cocaine use is associated with abnormalities in both brain structure and function within and interactions between regions, previous studies have been limited to interrogating structure and function independently, and the detected neural differences have not been applied to independent samples to assess the clinical relevance of results. We investigated consequences of structural differences on resting-state functional connectivity in cocaine addiction and tested whether resting-state functional connectivity of the identified circuits predict relapse in an independent cohort...
February 20, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28329653/introducing-public-health-themes-in-clinical-dermatology
#2
Scott A Norton
The ACGME's Core Competencies comprise six domains, which in turn contain dozens of often overlapping milestones. Several competencies explicitly invoke public health topics - but if one wears the right set of lenses, nearly every milestone, nearly every aspect of health and medicine, can be viewed from a public health perspective. Why then is Dermatology generally taught - and practiced - in an Intensive Care manner, where seemingly unlimited diagnostic & therapeutic efforts focus on single individuals, not the community?In this presentation, I argue that topics of public health concern should not be relegated to the minor leagues of GME...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28325384/-therapeutic-education-of-children-who-are-victims-or-at-risk-of-a-stroke
#3
Delphine Micaëlli
Therapeutic patient education is one of the health improvement projects. It provides personalised support for a child who has suffered or is at risk of suffering a stroke, and their family. This approach requires the sharing and transfer of knowhow, behaviour and attitude on the part of specially trained health professionals.
March 2017: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/28324932/an-ict-and-mobile-health-integrated-approach-to-optimize-patients-education-on-hypertension-and-its-management-by-physicians-the-patients-optimal-strategy-of-treatment-post-pilot-study
#4
Fabio Albini, Xiaoqiu Liu, Camilla Torlasco, Davide Soranna, Andrea Faini, Renata Ciminaghi, Ada Celsi, Matteo Benedetti, Antonella Zambon, Marco di Rienzo, Gianfranco Parati
INTRODUCTION: Uncontrolled hypertension is largely attributed to unsatisfactory doctor's engagement in its optimal management and to poor patients' compliance to therapeutic interventions. ICT and mobile Health solutions might improve these conditions, being widely available and providing highly effective communication strategies. OBJECTIVE: To evaluate whether ICT and mobile Health tools are able to improve hypertension control by improving doctors' engagement and by increasing patients' education and involvement, and their compliance to lifestyle modification and prescribed drug therapy...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28323111/nanoparticles-for-tumor-immunotherapy
#5
REVIEW
Xinlong Zang, Xiuli Zhao, Haiyang Hu, Mingxi Qiao, Yihui Deng, Dawei Chen
Although most researches and therapies have been focused on the tumor itself, it is becoming clear that immune cells can not only suppress tumor development but support and maintain their malignant type. Promising recent developments in immunology will provide opportunities for tumor-specific immunotherapy, which can orchestrate the patients immune system to target, fight and eradicate cancer cells without destroying healthy cells. However, antitumor immunity driven by self-immune system alone may be therapeutically insufficient...
March 18, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28323110/yeast-mediated-mrna-delivery-polarizes-immuno-suppressive-macrophages-towards-an-immuno-stimulatory-phenotype
#6
Michelle Seif, Jessica Hoppstädter, Frank Breinig, Alexandra K Kiemer
Macrophages have increasingly gained interest as a therapeutic target since they represent an integral component of the tumor microenvironment. In fact, M2 macrophage accumulation in solid tumors is associated with poor prognosis and therapy failure. Therefore, reprogramming M2 macrophages towards an M1 phenotype with anti-tumor activity by gene therapy represents a promising therapeutic approach. Herein, we describe recombinant Saccharomyces cerevisiae as a novel gene delivery vehicle for primary human macrophages...
March 17, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28322070/enhancing-clinical-communication-in-dermatologists-a-personalized-educational-intervention
#7
Zoi Tsimtsiou, Charitini Stavropoulou, Noni Papastefanou, Christos Lionis
OBJECTIVES: Effective communication is a vital component of patient-centered consultations with favourable treatment outcomes. This study aimed in testing the effectiveness of a personalized, communication training program for dermatologists in their practices. METHODS: Fifteen dermatologists were offered the educational intervention NO.TE.S. (Non Technical Skills). Depending on the dermatologists' needs, seven to nine sessions with a 60-minute duration were performed, focusing on: patient-centered care, principles of Neurolinguistic Programming, a guide to the medical interview, principles of motivational interviewing and self-care...
March 21, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28318518/-returning-to-work-after-an-acute-coronary-syndrome-when-waiting-is-wasting
#8
F Latil, M C Iliou, C Boileau, J X Pietri, C Lechien, P Ha-Vinh, C Guimond
BACKGROUND: Return to work (RTW) after acute coronary syndrome (ACS) is an important issue for the patient's future. AIMS: The study aim was to determine whether RTW practice complies with guidelines or is delayed by failure in patient management. We analysed the factors influencing RTW beyond the 90-day period recommended by guidelines. METHODS: We conducted a survey of 216 self-employed workers admitted to the hospital for ACS using self-report questionnaires and medical examination...
March 16, 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/28316784/characteristics-of-an-optimized-patient-information-material-for-elderly-patients-with-obstructive-pulmonary-diseases-based-on-patients-and-experts-assessment
#9
Gábor Tomisa, Alpár Horváth, Brigitta Dombai, Lilla Tamási
BACKGROUND: Life-long regular use of drugs is necessary in chronic diseases like asthma and COPD. There are several methods to improve adherence including patient information and education; however, their effectiveness on the basis of practical experience is often lower than originally planned and expected. Our objective is to develop a patient information material based on the recommendations of patients and their treating healthcare professionals to fulfill their needs. METHODS: A survey was conducted among pulmonologists (N = 262), asthma nurses (N = 102), general practitioners (N = 321) and patients with obstructive pulmonary disease (N = 978) using on line questionnaires...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28315491/vibrating-mesh-nebulizer-maintenance-by-cf-patients-results-from-a-french-survey
#10
Melisande Baravalle-Einaudi, Nadine Dufeu, Christian Dupont, Laurent Vecellio, Bertrand Delaisi, Ania Carsin, Jean-Christophe Dubus
PURPOSE OF THE STUDY: Vibrating-mesh nebulizers are widely used at home for cystic fibrosis (CF) treatment, with a therapeutic efficiency closely linked to the mesh performance. This national study looks at the maintenance at home by CF patients and their families of the mesh of the eFlow(®)rapid nebulizer. Ninety-two patients from 34 French CF centers, treated at home with inhaled drugs delivered with a vibrating-mesh nebulizer, answered to a phone standardized questionnaire specifying the different techniques of maintenance of the nebulizer...
March 14, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28315415/best-practices-in-relational-skills-training-for-medical-trainees-and-providers-an-essential-element-of-addressing-aces-and-promoting-resilience
#11
Eran Magen, Horace M DeLisser
Medical providers' ability to form strong therapeutic alliances with patients is an essential clinical skill that is associated with a higher quality of care and improved provider well being. However, comparatively few medical providers exhibit adequate relational skills, which serve to convey respect, communicate caring, and build trust between the medical provider and the patient. A growing number of medical training programs and continuing medical education programs have begun to incorporate relational skills training, but the results have been highly variable in terms of training methods and impact...
March 14, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28304416/gynecologic-malignancies-in-pregnancy-balancing-fetal-risks-with-oncologic-safety
#12
Christina N Cordeiro, Mary L Gemignani
Importance: Cancer occurs in 0.05% to 0.1% of all pregnancies. Despite literature reporting good oncologic and fetal outcomes in women treated for cancer during pregnancy, as many as 44% of gynecologists would offer termination, and 37% would not administer chemotherapy or radiotherapy in pregnancy. Objectives: The aims of this study were to summarize current recommendations for the treatment of cervical and ovarian cancers in pregnancy and to review updates on existing knowledge regarding the safety of surgical and chemotherapeutic treatments in pregnancy, including both oncologic and fetal outcomes...
March 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/28302552/exploring-overlaps-between-the-genomic-and-environmental-determinants-of-lvh-and-stroke-a-multicenter-study-in-west-africa
#13
Abiodun M Adeoye, Bruce Ovbiagele, Philip Kolo, Lambert Appiah, Akinyemi Aje, Oladimeji Adebayo, Fred Sarfo, Joshua Akinyemi, Gregory Adekunle, Francis Agyekum, Vincent Shidali, Okechukwu Ogah, Dan Lackland, Mulugeta Gebregziabher, Donna Arnett, Hemant K Tiwari, Rufus Akinyemi, Ojo Olakanmi Olagoke, Ayodipupo Sikiru Oguntade, Taiwo Olunuga, Kelechi Uwanruochi, Carolyn Jenkins, Patrick Adadey, Henry Iheonye, Lukman Owolabi, Reginald Obiako, Samuel Akinjopo, Kevin Armstrong, Albert Akpalu, Adekunle Fakunle, Raelle Saulson, Mayowa Aridegbe, Paul Olowoyo, Godwin Osaigbovo, Josephine Akpalu, Bimbo Fawale, Philip Adebayo, Oyedunni Arulogun, Philip Ibinaiye, Atinuke Agunloye, Naser Ishaq, Kolawole Wahab, Onoja Akpa, Omisore Adeleye, Andrew Bock-Oruma, Godwin Ogbole, Sylvia Melikam, Joseph Yaria, Luqman Ogunjimi, Abdul Salaam, Taofiki Sunmonu, Akintomiwa Makanjuola, Temitope Farombi, Ruth Laryea, Ezinne Uvere, Salaam Kehinde, Innocent Chukwuonye, Paschal Azuh, Morenikeji Komolafe, Adeseye Akintunde, Olugbo Obiabo, Olusegun Areo, Issa Kehinde, Adeniyi G Amusa, Mayowa Owolabi
BACKGROUND: Whether left ventricular hypertrophy (LVH) is determined by similar genomic and environmental risk factors with stroke, or is simply an intermediate stroke marker, is unknown. OBJECTIVES: We present a research plan and preliminary findings to explore the overlap in the genomic and environmental determinants of LVH and stroke among Africans participating in the SIREN (Stroke Investigative Research and Education Network) study. METHODS: SIREN is a transnational, multicenter study involving acute stroke patients and age-, ethnicity-, and sex-matched control subjects recruited from 9 sites in Ghana and Nigeria...
March 13, 2017: Global Heart
https://www.readbyqxmd.com/read/28299032/demographic-and-life-styles-determinants-of-somatic-complaints-structures-a-cross-sectional-study-on-a-large-sample-of-iranian-adults-using-factor-mixture-model
#14
Zahra Heidari, Awat Feizi, Hamidreza Roohafza, Ammar Hassanzadeh Keshteli, Fatemeh Zahra Shiravi, Payman Adibi
BACKGROUND: To identify somatic complaints dimensions, classify studied population and study the association of demographic and lifestyle factors with somatic complaints dimensions. METHODS: In a cross-sectional study conducted on 4763 Iranian adults, somatic complaints were assessed using a comprehensive 30-item questionnaire. Self-administered standard questionnaires were used to assess demographic and lifestyle factors. Factor mixture modeling (FMM) was used to identify somatic complaints dimensions and classify studied population...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28295948/nurses-experiences-of-delivering-care-in-acute-inpatient-mental-health-settings-a-narrative-synthesis-of-the-literature
#15
REVIEW
Marianne Wyder, Carolyn Ehrlich, David Crompton, Leianne McArthur, Caroline Delaforce, Fiona Dziopa, Shulamit Ramon, Elizabeth Powell
Inpatient psychiatric care requires a balance between working with consumers' priorities and goals, managing expectations of the community, legal, professional and service responsibilities. In order to improve service delivery within acute mental health units, it is important to understand the constraints and facilitating factors for good care. We conducted a systematic narrative synthesis, where findings of qualitative studies are synthesised to generate new insights. 21 articles were identified. Our results show that personal qualities, professional skills as well as environmental factors all influence the ability to provide recovery focused care...
March 14, 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/28295744/contributing-factors-for-therapeutic-diet-adherence-in-patients-receiving-haemodialysis-treatment-an-integrative-review
#16
REVIEW
Lissete González Oquendo, José Miguel Morales Asencio, Candela Bonill de Las Nieves
AIMS AND OBJECTIVES: The objective of this integrative review is to identify the factors that contribute to diet adherence in people suffering from kidney disease who are receiving haemodialysis treatment. BACKGROUND: Adherence to the therapeutic regimen determines therapeutic success, quality of life, and survival in patients on haemodialysis. Lack of diet adherence ranges from 25 to 86% in patients receiving haemodialysis treatment and affects patient morbidity and mortality...
March 15, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28295236/pharmacology-and-therapeutics-education-in-eu-needs-harmonisation-and-modernisation-a-cross-sectional-survey-among-185-medical-schools-in-27-countries
#17
D J Brinkman, J Tichelaar, M Okorie, L Bissell, T Christiaens, R Likic, R Mačiulaitis, J Costa, E J Sanz, B I Tamba, S R Maxwell, M C Richir, M A van Agtmael
Effective teaching in pharmacology and clinical pharmacology and therapeutics (CPT) is necessary to make medical students competent prescribers. However, the current structure, delivery and assessment of CPT education in the European Union (EU) is unknown. We sent an online questionnaire to teachers with overall responsibility for CPT education in EU medical schools. Questions focused on undergraduate teaching and assessment of CPT, and students' preparedness for prescribing. 185 medical schools (64%) from 27 EU countries responded...
March 15, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28293906/who-should-be-considered-for-islet-transplantation-alone
#18
REVIEW
Nantia Othonos, Pratik Choudhary
PURPOSE OF REVIEW: Episodic hypoglycemia is an almost inevitable consequence of exogenous insulin treatment of type 1 diabetes, and in up to 30% of patients, this can lead to impaired awareness of hypoglycemia. This predisposes to recurrent severe hypoglycemia and has a huge impact on quality of life. Although many patients can get resolution of severe hypoglycemia through novel education and technology, some patients continue to have ongoing life-threatening hypoglycemia. Islet transplantation offers an alternative therapeutic option for these patients, in whom these conventional approaches have been unsuccessful...
April 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28291976/effects-of-a-group-psychoeducation-program-on-self-stigma-empowerment-and-perceived-discrimination-of-persons-with-schizophrenia
#19
Slađana Štrkalj Ivezić, Marijan Alfonso Sesar, Lana Mužinić
BACKGROUND: Self-stigma adversely affects recovery from schizophrenia. Analyses of self stigma reduction programs discovered that few studies have investigated the impact of education about the illness on self-stigma reduction. The objective of this study was to determine whether psychoeducation based on the principles of recovery and empowerment using therapeutic group factors assists in reduction of self-stigma, increased empowerment and reduced perception of discrimination in patients with schizophrenia...
March 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28291720/congenital-cytomegalovirus-infection-in-pregnancy-and-the-neonate-consensus-recommendations-for-prevention-diagnosis-and-therapy
#20
REVIEW
William D Rawlinson, Suresh B Boppana, Karen B Fowler, David W Kimberlin, Tiziana Lazzarotto, Sophie Alain, Kate Daly, Sara Doutré, Laura Gibson, Michelle L Giles, Janelle Greenlee, Stuart T Hamilton, Gail J Harrison, Lisa Hui, Cheryl A Jones, Pamela Palasanthiran, Mark R Schleiss, Antonia W Shand, Wendy J van Zuylen
Congenital cytomegalovirus is the most frequent, yet under-recognised, infectious cause of newborn malformation in developed countries. Despite its clinical and public health importance, questions remain regarding the best diagnostic methods for identifying maternal and neonatal infection, and regarding optimal prevention and therapeutic strategies for infected mothers and neonates. The absence of guidelines impairs global efforts to decrease the effect of congenital cytomegalovirus. Data in the literature suggest that congenital cytomegalovirus infection remains a research priority, but data are yet to be translated into clinical practice...
March 10, 2017: Lancet Infectious Diseases
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