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https://www.readbyqxmd.com/read/28636540/implementation-and-utilization-of-the-molecular-tumor-board-to-guide-precision-medicine
#1
REVIEW
Shuko Harada, Rebecca Arend, Qian Dai, Jessica A Levesque, Thomas S Winokur, Rongjun Guo, Martin J Heslin, Lisle Nabell, L Burt Nabors, Nita A Limdi, Kevin A Roth, Edward E Partridge, Gene P Siegal, Eddy S Yang
BACKGROUND: With rapid advances in genomic medicine, the complexity of delivering precision medicine to oncology patients across a university health system demanded the creation of a Molecular Tumor Board (MTB) for patient selection and assessment of treatment options. The objective of this report is to analyze our progress to date and discuss the importance of the MTB in the implementation of personalized medicine. MATERIALS AND METHODS: Patients were reviewed in the MTB for appropriateness for comprehensive next generation sequencing (NGS) cancer gene set testing based on set criteria that were in place...
June 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28635191/impact-of-a-nutrition-educational-program-in-a-group-of-type-2-diabetes-patients-already-involved-in-a-wider-group-care-plan-and-not-achieving-complete-target-an-observational-study
#2
Anna Comba, Alessandra Ardizzone, Laura Leto, Mauro Feola
Type 2 diabetes is one of the most frequent chronic degenerative diseases in the world (5.4% in Italy); it has many chronic consequences with a significant impact either on expectation or quality of life. About 80-90% of type 2 diabetes patients is either overweight or obese, condition that can cause many more negative consequences than in individuals in the same conditions but with normal weight. The aim of the research is to assess if diabetic people who cannot reach the goals of glycemic control, good eating habits and weight loss can eventually obtain, with an individualized care plan, long lasting improvements...
May 18, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/28630370/evidence-for-therapeutic-patient-education-interventions-to-promote-cardiovascular-patient-self-management-a-scientific-statement-for-healthcare-professionals-from-the-american-heart-association
#3
REVIEW
Susan Barnason, Connie White-Williams, Laura P Rossi, Mae Centeno, Deborah L Crabbe, Kyoung Suk Lee, Nancy McCabe, Julie Nauser, Paula Schulz, Kelly Stamp, Kathryn Wood
BACKGROUND: The burden of cardiovascular disease as a chronic illness increasingly requires patients to assume more responsibility for their self-management. Patient education is believed to be an essential component of cardiovascular care; however, there is limited evidence about specific therapeutic patient education approaches used and the impact on patient self-management outcomes. METHODS AND RESULTS: An integrative review of the literature was conducted to critically analyze published research studies of therapeutic patient education for self-management in selected cardiovascular conditions...
June 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28629762/targeting-the-tumor-and-its-associated-stroma-one-and-one-can-make-three-in-adoptive-t-cell-therapy-of-solid-tumors
#4
Anna Mondino, Gerlanda Vella, Laura Icardi
Adoptive T cell therapy (ACT) has become a promising immunotherapeutic option for cancer patients. The proof for ACT therapeutic efficacy was first obtained with allogenic T cells and then reproduced with T cells isolated from patients' tumor samples (i.e. tumor-infiltrating lymphocytes). It is now clear that specificity of ACT products can be educated by genetically engineering T cells with classical T Cell Receptors (TCR) or chimeric antigen receptors (CAR). To date a poor accessibility of the tumor mass and a hostile microenvironment, influenced by genetic and epigenetic instability, mainly limit ACT therapeutic efficacy in the case of solid tumors...
June 15, 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/28628385/serious-games-for-psychotherapy-a-systematic-review
#5
Christiane Eichenberg, Markus Schott
INTRODUCTION: In the evolving digital age, media applications are increasingly playing a greater role in the field of psychotherapy. While the Internet is already in the phase of being established when it comes to the care of mental disorders, experimentation is going on with other modern media such as serious games. A serious game is a game in which education and behavior change is the goal, alongside with entertainment. OBJECTIVE: The objective of the present article was to provide a first empirical overview of serious games applied to psychotherapy and psychosomatic rehabilitation...
June 2017: Games for Health
https://www.readbyqxmd.com/read/28626381/nilotinib-induced-acute-pancreatitis-in-a-patient-with-chronic-myeloid-leukemia
#6
Vihang Patel, Anil Pattisapu, Karim Attia, John Weiss
Nilotinib, a second-generation tyrosine kinase inhibitor, is used for treatment of chronic myeloid leukemia (CML); it has been widely used especially for imatinib-resistant CML. Despite being a novel drug in this therapeutic class, it has the potential to be harmful. We present the case of an elderly woman who developed life-threatening acute pancreatitis as an adverse event after having started the drug. There is only one reported case in the literature of nilotinib-induced acute pancreatitis. The purpose of this case report is to educate physicians who prescribe this medication to be aware of potential life-threatening adverse events...
May 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28625860/impact-of-telephone-counseling-on-the-quality-of-life-of-patients-discharged-after-coronary-artery-bypass-grafts
#7
Ali Bikmoradi, Behnam Masmouei, Mohammad Ghomeisi, Ghodratollah Roshanaei, Italo Masiello
BACKGROUND: This study aimed to assess the impact of telephone counseling on quality of life in patients with coronary artery bypass graft. METHODS: A quasi-experimental study was conducted with 71 discharged patients after coronary artery bypass graft surgery at Ekbatan Edcuational hospital in Hamadan, Iran, in 2014. The patients were randomly allocated into intervention (n=36) and control group (n=35). The intervention group received education and counseling about therapeutic plan via telephone after discharge...
June 9, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28624898/improving-diabetes-care-at-primary-care-level-with-a-multistrategic-approach-results-of-the-diaprem-programme
#8
Mariana Prestes, Maria A Gayarre, Jorge F Elgart, Lorena Gonzalez, Enzo Rucci, Jose M Paganini, Juan J Gagliardino
AIM: To present results, 1 year postimplementation at primary care level, of an integrated diabetes care programme including systemic changes, education, registry (clinical, metabolic, and therapeutic indicators), and disease management (DIAPREM). METHODS: We randomly selected and trained 15 physicians and 15 nurses from primary care units of La Matanza County (intervention-IG) and another 15 physicians/nurses to participate as controls (control-CG). Each physician-nurse team controlled and followed up 10 patients with type 2 diabetes for 1 year; both groups used structured medical records...
June 17, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28624292/the-use-of-non-prescription-medicines-during-lactation-a-qualitative-study-of-community-pharmacists-attitudes-and-perspectives
#9
Tin Fei Sim, H Laetitia Hattingh, Jillian Sherriff, Lisa B G Tee
BACKGROUND: Community pharmacists play a significant role in the provision of non-prescription medicines. There is evidence that women self-medicate and use non-prescription medicines whilst breastfeeding. Studies have demonstrated that breastfeeding women are likely to seek advice from pharmacists, presenting a unique opportunity for pharmacists to provide on-going support of these women especially in relation to the appropriate use of non-prescription medicines. OBJECTIVES: This study aimed to explore community pharmacists' attitudes and perspectives towards the use of non-prescription medicines during breastfeeding...
June 10, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28622592/second-generation-h1-antihistamines-interaction-with-food-and-alcohol-a-systematic-review
#10
REVIEW
Paweł Paśko, Tomasz Rodacki, Renata Domagała-Rodacka, Krzysztof Palimonka, Monika Marcinkowska, Danuta Owczarek
Histamine is a mediator of many physiological processes. It plays an important role in modulating allergy reactions and immune system responses. H1 receptor is a therapeutic target for drugs applied in allergic diseases such as allergic rhinoconjunctivitis, urticarial, or atopic dermatitis. H1-antihistamines display different chemical structures, pharmacokinetics and a potential for drug-drug and drug-food interactions. Drug-food interactions are known to reduce therapeutic effects of the medicine, as well as to induce a potent adverse drug reactions...
June 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28622136/exploring-medical-student-s-conceptions-of-substance-use-a-follow-up-evaluation
#11
Dawn L Lindsay, Holly Hagle, Piper Lincoln, Jessica Williams, Peter F Luongo
BACKGROUND: Despite the devastating impact of alcohol and other drug involvement and misuse within society, medical students still receive very limited exposure to these issues. The Scaife Advanced Medical Student Fellowship in Alcohol and Other Drug Dependency, offered by the Institute for Research, Education and Training in Addictions for over 10 years, offers a unique, three-week intensive educational experience including didactic, observation and experiential learning in these topics to first year medical students...
June 16, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28620276/an-analysis-of-a-novel-short-term-therapeutic-psychoeducational-program-for-children-and-adolescents-with-chronic-neurological-illness-and-their-parents-feasibility-and-efficacy
#12
Bonglim Joo, Young-Mock Lee, Heung Dong Kim, Soyong Eom
The purpose of this intervention was to develop a therapeutic psycho-educational program that improves quality of life in children and adolescents who are experiencing chronic neurological illness, including epilepsy, and their parents, and to analyze the intervention's feasibility and efficacy and participants' satisfaction. Participants were eight children (n = 8) and adolescents and their parents; participating children were experiencing chronic neurological illness with psychological comorbidity; children with intellectual impairment were excluded (IQ < 80)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28619311/treating-individuals-with-amputations-in-therapeutic-massage-and-bodywork-practice-a-qualitative-study
#13
Sarah Shue, Ania Kania-Richmond, Thalia Mulvihill, Niki Munk
INTRODUCTION: Best practices for massage therapy and bodywork (TMB) treatment of individuals with amputations are not well established. Although anecdotal observations are available, they have limited applicability for informing effective massage therapy and bodywork approaches for individuals with amputations. This study is part of a multifaceted research program seeking to establish a foundation for education and investigation of TMB for amputation related conditions/symptomology. The purpose of this study was to understand how TMB practitioners approach and treat individuals with amputations and their perceptions of outcomes...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28617785/haemochromatosis-evaluating-the-effectiveness-of-a-novel-patient-self-management-approach-to-venesection-as-blood-donation
#14
Sonam Mishra, Dalice Sim, Peter Flanagan
AIM: We set out to evaluate the effectiveness of a new model of self management of haemochromatosis, whereby patients with stable ferritin control were discharged from the New Zealand Blood Service (NZBS) therapeutic venesection clinic and educated to manage their own venesection by regular blood donation and annual serum ferritin check by their general practitioner. METHOD: Data regarding the frequency of blood donation and serum ferritin level were collected from the NZBS and Concerto records of haemochromatosis patients in the Wellington region who had been discharged back to the care of their general practitioner between January 2014 and June 2015...
June 16, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28617688/compliance-with-the-prescribed-occlusion-treatment-for-amblyopia
#15
Aldo Vagge, Leonard B Nelson
PURPOSE OF REVIEW: The present review article is an update on the current evidence about compliance to the prescribed occlusion treatment for amblyopia. In particular, the authors focus on the predictors and causes of noncompliance and possible interventions to increase it. RECENT FINDINGS: Compliance with prescribed occlusion treatment is often challenging. Reported rates of compliance range widely from 49% to 87%. Objective monitoring of occlusion has opened up new research opportunities and allow the design of effective therapeutic regimens...
June 14, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28617543/study-on-the-clinical-application-of-the-mrs-in-the-cognitive-assessment-after-stroke
#16
S-Y Wang, M Wang, X-X Wang, W Chen, C Sheng, Z-K Gong
OBJECTIVE: To discuss the value of the application of the magnetic resonance spectroscopy (MRS) in the assessment of cognitive function impairment and the observation of therapeutic effect. PATIENTS AND METHODS: 30 patients with cognitive impairment after stroke (cognitive impairment group) and 30 patients with no apparent cognitive impairment (control group of the stroke) were selected through the screening of the mini-mental state examination (MMSE) scale, and another 30 healthy volunteers were selected (control group of the health)...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28612634/lysosomal-acid-lipase-deficiency-a-form-of-non-obese-fatty-liver-disease-nofld
#17
H H A-Kader
With the growing obesity epidemic, nonalcoholic fatty liver disease (NAFLD) is rapidly becoming one of the leading causes of liver disease worldwide. Although obesity is a main risk factor for the development of NAFLD, it can also develop in lean subjects and can be encountered in different clinical setting and in association with an array of genetic, metabolic, nutritional, infectious and drug-induced disorders. Areas covered: This article discusses causes of fatty liver in non-obese subjects focusing on Lysosomal acid lipase deficiency (LAL-D), a commonly overlooked disorder reviewing its prevalence, genetics, pathogenesis, clinical features, diagnosis and treatment...
June 14, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28608232/emotional-distress-among-physician-residents-and-fellows-an-observational-study-of-trainees-seeking-counseling-visits
#18
Anna Golob, Lauren A Beste, Mindy Stern, Kay Johnson
OBJECTIVE: Emotional distress, burnout, and depression occur frequently among graduate medical education (GME) trainees and may negatively affect patient care, education, and well-being. The authors aimed to characterize the causes and severity of distress among GME trainees seeking on-site counseling services at a large, multi-site, university-based training program in the USA. METHODS: The authors analyzed visits of all GME trainees seeking counseling from 2009 to 2012 and described trainee characteristics, level of distress, chief and secondary complaints, and initial visit outcomes...
June 12, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28606972/patient-driven-second-opinions-in-oncology-a-systematic-review
#19
Marij A Hillen, Niki M Medendorp, Joost G Daams, Ellen M A Smets
BACKGROUND: Although patient-driven second opinions are increasingly sought in oncology, the desirability of this trend remains unknown. Therefore, this systematic review assesses evidence on the motivation for and frequency of requests for second opinions and examines how they evolve and their consequences for oncological practice. MATERIALS AND METHODS: Relevant databases were sought using the terms "cancer," "second opinion," and "self-initiated." Included were peer-reviewed articles that reported on patient-initiated second opinions within oncology...
June 12, 2017: Oncologist
https://www.readbyqxmd.com/read/28605628/topiramate-associated-sexual-dysfunction-a-systematic-review
#20
REVIEW
Louis Wei-Hsi Chen, Melody Yun-Si Chen, Kuo-Yen Chen, Hung-Sheng Lin, Chia-Chang Chien, Hsin-Ling Yin
INTRODUCTION: Sexual pharmacotoxicity renders patients with epilepsy at a risk for sexual dysfunction (SD). This study is aimed to analyze the relationship between sexual function and topiramate to avoid topiramate-associated SD. METHODS: A systematic review following the PRISMA guidelines was performed to elucidate any SD occurrence in patients receiving topiramate. RESULTS: A total of 17 publications were reviewed. Based on limited polytherapy observational studies, the frequency of self-reported topiramate-associated SD, libido disorder, and orgasmic disorder in patients with polytherapy was 9...
June 9, 2017: Epilepsy & Behavior: E&B
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