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https://www.readbyqxmd.com/read/28972999/effects-of-insulin-like-growth-factors-on-early-embryonic-chick-limb-myogenesis
#1
Rabeea Hazim Mohammed, Helen Anderton, John Michael Brameld, Dylan Sweetman
Limb muscles derive from pax3 expressing precursor cells that migrate from the hypaxial somite into the developing limb bud. Once there they begin to differentiate and express muscle determination genes such as MyoD. This process is regulated by a combination of inductive or inhibitory signals including Fgf18, retinoic acid, HGF, Notch and IGFs. IGFs are well known to affect late stages of muscle development and to promote both proliferation and differentiation. We examined their roles in early stage limb bud myogenesis using chicken embryos as an experimental model...
2017: PloS One
https://www.readbyqxmd.com/read/28939196/molecular-identification-of-an-insulin-growth-factor-binding-protein-igfbp-and-its-potential-role-in-an-insulin-like-peptide-system-of-the-pearl-oyster-pinctada-fucata
#2
Hua Zhang, Yu Shi, Maoxian He
Insulin-like growth factors (IGFs) play critical roles in regulating metabolism, growth, and reproduction in invertebrates. IGF binding proteins (IGFBPs) serve as major regulators of IGF activity and regulate endocrine system. In the present study, the full-length cDNA of an igfbp was identified from the pearl oyster, Pinctada fucata, using expressed sequence tag (EST) sequence. The 1124bp Pfigfbp cDNA contains a 465bp open reading frame (ORF) encoding a putative protein of 154 amino acids, a 5'-untranslated region (UTR) of 238bp, and a 3'-UTR of 394bp (not including polyA+)...
September 20, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28934637/igf-system-targeted-therapy-therapeutic-opportunities-for-ovarian-cancer
#3
REVIEW
J A L Liefers-Visser, R A M Meijering, A K L Reyners, A G J van der Zee, S de Jong
The insulin-like growth factor (IGF) system comprises multiple growth factor receptors, including insulin-like growth factor 1 receptor (IGF-1R), insulin receptor (IR) -A and -B. These receptors are activated upon binding to their respective growth factor ligands, IGF-I, IGF-II and insulin, and play an important role in development, maintenance, progression, survival and chemotherapeutic response of ovarian cancer. In many pre-clinical studies anti-IGF-1R/IR targeted strategies proved effective in reducing growth of ovarian cancer models...
September 8, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28928383/human-stem-cells-alter-the-invasive-properties-of-somatic-cells-via-paracrine-activation-of-mtorc1
#4
Margit Rosner, Ha Thi Thanh Pham, Richard Moriggl, Markus Hengstschläger
Controlled invasion is essential during many physiological processes, whereas its deregulation is a hallmark of cancer. Here we demonstrate that embryonic, induced pluripotent and amniotic fluid stem cells share the property to induce the invasion of primary somatic cells of various origins through insulin-like growth factor I (IGF-I)- or II (IGF-II)-mediated paracrine activation of mechanistic target of rapamycin complex 1 (mTORC1). We propose a model in which downstream of mTORC1 this stem cell-induced invasion is mediated by hypoxia-inducible factor 1-alpha (HIF-1α)-regulated matrix metalloproteinases...
September 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28927688/effects-of-dietary-hawthorn-extract-on-growth-performance-immune-responses-growth-and-immune-related-genes-expression-of-juvenile-golden-pompano-trachinotus-ovatus-and-its-susceptibility-to-vibrio-harveyi-infection
#5
Xiaohong Tan, Zhenzhu Sun, Zhong Huang, Chuanpeng Zhou, Heizhao Lin, Lianjie Tan, Pengwei Xun, Qian Huang
The present study was conducted to investigate the effects of dietary hawthorn extract (HTE) supplementation on growth performance, immune responses, hepatic antioxidant abilities, growth- and immune-related and heat shock protein genes expression and resistance to the pathogen Vibrio harveyi in Trachinotus ovatus. A basal diet supplemented with HTE at 0 (Diet 1), 0.50 (Diet 2), 1.00 (Diet 3), 2.00 (Diet 4), 4.00 (Diet 5) and 10.00 (Diet 6) g kg(-1) were fed to golden pompano for 8 weeks. The highest final body weight, weight gain rate, specific growth rate, feed efficiency ratio and protein efficiency rate were observed in fish fed Diet 2 (P < 0...
September 18, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28912305/effects-of-liraglutide-on-weight-loss-fat-distribution-and-%C3%AE-cell-function-in-obese-subjects-with-prediabetes-or-early-type-2-diabetes
#6
Francesca Santilli, Paola G Simeone, Maria T Guagnano, Marika Leo, Marica T Maccarone, Augusto Di Castelnuovo, Cristina Sborgia, Riccardo C Bonadonna, Ermanno Angelucci, Virginia Federico, Stefano Cianfarani, Lamberto Manzoli, Giovanni Davì, Armando Tartaro, Agostino Consoli
OBJECTIVE: Obesity is associated with an increased risk of type 2 diabetes and cardiovascular complications. The risk depends significantly on adipose tissue distribution. Liraglutide, a glucagon-like peptide 1 analog, is associated with weight loss, improved glycemic control, and reduced cardiovascular risk. We determined whether an equal degree of weight loss by liraglutide or lifestyle changes has a different impact on subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) in obese subjects with prediabetes or early type 2 diabetes...
September 14, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28891439/the-regulation-of-differentiation-of-mesenchymal-stem-cells-into-skeletal-muscle-a-look-at-signalling-molecules-involved-in-myogenesis
#7
Bethany Hodgson, Reza Mafi, Pouya Mafi, Wasim Khan
Mesenchymal Stem Cells (MSCs) are an attractive option for the development of treatment for musculoskeletal pathologies due to their wide availability, clinical safety and multiple techniques available. Understanding the control of MSC differentiation into skeletal muscle is vital for developing protocols and therapeutic applications that are safe and effective. This paper therefore aims to review the current understanding of factors that regulate the differentiation of MSCs into skeletal muscle. Medline, Embase, Pubmed and Web of Science were searched December 2015 using the terms 'differentia*, skeletal*, skeleton*, myocyt*, myogen* and mesenchym* stem-cell*...
September 6, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28829218/association-of-trna-methyltransferase-nsun2-igf-ii-molecular-signature-with-ovarian-cancer-survival
#8
Jia-Cheng Yang, Eric Risch, Meiqin Zhang, Chan Huang, Huatian Huang, Lingeng Lu
AIM: To investigate the association between NSUN2/IGF-II signature and ovarian cancer survival. METHODS: Using a publicly accessible dataset of RNA sequencing and clinical follow-up data, we performed Classification and Regression Tree and survival analyses. RESULTS: Patients with NSUN2 (high) IGF-II (low) had significantly superior overall and disease progression-free survival, followed by NSUN2 (low) IGF-II (low), NSUN2 (high) IGF-II (high) and NSUN2 (low) IGF-II (high) (p < 0...
August 22, 2017: Future Oncology
https://www.readbyqxmd.com/read/28795851/selective-induction-of-apoptosis-in-mcf7-cancer-cell-by-targeted-liposomes-functionalized-with-mannose-6-phosphate
#9
Cristina Minnelli, Laura Cianfruglia, Emiliano Laudadio, Roberta Galeazzi, Michela Pisani, Emanuela Crucianelli, Davide Bizzaro, Tatiana Armeni, Giovanna Mobbili
Liposomes are versatile platforms to carry anticancer drugs in targeted drug delivery; they can be surface modified by different strategies and, when coupled with targeting ligands, are able to increase cellular internalization and organelle-specific drug delivery. An interesting strategy of antitumoral therapy could involve the use of lysosomotropic ligand-targeted liposomes loaded with molecules, which can induce lysosomal membrane permeabilization (LMP), leakage of cathepsins into the cytoplasm and subsequent apoptosis...
August 10, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28727231/nulliparity-is-associated-with-subtle-adverse-metabolic-outcomes-in-overweight-obese-mothers-and-their-offspring
#10
Sumudu N Seneviratne, José G B Derraik, Yannan Jiang, Lesley M E McCowan, Silmara Gusso, Janene B Biggs, Graham K Parry, Valentina Chiavaroli, Wayne S Cutfield, Paul L Hofman
BACKGROUND: We aimed to evaluate metabolic outcomes in overweight/obese nulliparous and multiparous women and their offspring. STUDY DESIGN: Seventy-two overweight and obese women who participated in a randomized controlled trial of exercise in pregnancy were included in the study, comparing 18 nulliparous and 54 multiparous women and their singleton offspring. Women were assessed at 19 and 36 weeks of gestation. Fetal growth was measured using standard obstetric ultrasound techniques...
July 20, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28682900/doege-potter-syndrome-a-review-of-the-literature-including-a-new-case-report
#11
REVIEW
Guiyan Han, Zhimin Zhang, Xingbin Shen, Kunpeng Wang, Yang Zhao, Jianqiu He, Yu Gao, Xiujie Shan, Guohua Xin, Chunhui Li, Xiaoyan Liu
RATIONALE: We reviewed 76 published cases of Doege-Potter syndrome, and non-islet cell tumor hypoglycemia (NICTH) secondary to a solitary fibrous tumor (SFT) between 1989 and 2016, to study disease pathogenesis, diagnosis, and treatment of this rare paraneoplastic disease. Further, we report 1 new case of a patient presenting with Doege-Potter syndrome. PATIENTS CONCERNS: The tumors originated from the pleural cavity, lung, pelvis, liver, retroperitoneum, kidney, mediastinal, the sella, uterus, bladder, intestine, mandibular, and the thigh...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28681154/prediagnosis-circulating-insulin-like-growth-factors-and-pancreatic-cancer-survival
#12
Adetunji T Toriola, Mark Ziegler, Yize Li, Michael Pollak, Rachael Stolzenberg-Solomon
BACKGROUND: Prediagnosis obesity and diabetes are associated with survival from pancreatic cancer, but the underlying mechanisms have not been characterized. Because both are associated with dysregulation in circulating insulin-like growth factor (IGF) levels, we evaluated the associations of prediagnosis IGF levels (IGF-I, IGF-II) and IGF binding protein 3 (IGFBP-3) with pancreatic cancer survival. METHODS: Participants were subjects enrolled in the intervention arm of the PLCO Cancer Screening Trial who developed exocrine pancreatic cancer during follow-up (N = 178, 116 men and 67 women)...
July 5, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28666853/recombinant-bovine-growth-hormone-rbgh-enhances-somatic-growth-by-regulating-the-gh-igf-axis-in-fingerlings-of-gilthead-sea-bream-sparus-aurata
#13
Emilio J Vélez, Miquel Perelló, Sheida Azizi, Alberto Moya, Esmail Lutfi, Jaume Pérez-Sánchez, Josep A Calduch-Giner, Isabel Navarro, Josefina Blasco, Jaume Fernández-Borràs, Encarnación Capilla, Joaquim Gutiérrez
The growth hormone (GH)/insulin-like growth factors (IGFs) endocrine axis is the main growth-regulator system in vertebrates. Some authors have demonstrated the positive effects on growth of a sustained-release formulation of a recombinant bovine GH (rBGH) in different fish species. The aim of this work was to characterize the effects of a single injection of rBGH in fingerlings of gilthead sea bream on growth, GH-IGF axis, and both myogenic and osteogenic processes. Thus, body weight and specific growth rate were significantly increased in rBGH-treated fish respect to control fish at 6weeks post-injection, whereas the hepatosomatic index was decreased and the condition factor and mesenteric fat index were unchanged, altogether indicating enhanced somatic growth...
June 27, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28593921/hyperandrogenism-in-adolescent-girls-relationship-with-the-somatotrophic-axis
#14
María Isabel Hernandez, Patricia López, Ximena Gaete, Claudio Villarroel, Gabriel Cavada, Alejandra Avila, German Iñiguez, Fernando Cassorla
BACKGROUND: During puberty there is a physiologic increase in adrenal and ovarian androgens. It has been suggested that the somatotrophic axis may be related to the development of hyperandrogenism and anovulation in non-obese adult women with polycystic ovarian syndrome (PCOS). The objective of the study was to investigate whether ovarian androgen secretion in young postmenarchal girls is related to the function of their somatotropic axis. METHODS: This was a cross-sectional study of adolescent girls...
May 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28592512/higher-maternal-protein-intake-during-pregnancy-is-associated-with-lower-cord-blood-concentrations-of-insulin-like-growth-factor-igf-ii-igf-binding-protein-3-and-insulin-but-not-igf-i-in-a-cohort-of-women-with-high-protein-intake
#15
Karen M Switkowski, Paul F Jacques, Aviva Must, Marie-France Hivert, Abby Fleisch, Matthew W Gillman, Sheryl Rifas-Shiman, Emily Oken
Background: Prenatal exposure to dietary protein may program growth-regulating hormones, consequently influencing early-life growth patterns and later risk of associated chronic diseases. The insulin-like growth factor (IGF) axis is of particular interest in this context given its influence on pre- and postnatal growth and its sensitivity to the early nutritional environment.Objective: Our objective was to examine associations of maternal protein intake during pregnancy with cord blood concentrations of IGF-I, IGF-II, IGF binding protein-3 (IGFBP-3), and insulin...
July 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28575743/igf-ii-promotes-neuroprotection-and-neuroplasticity-recovery-in-a-long-lasting-model-of-oxidative-damage-induced-by-glucocorticoids
#16
E Martín-Montañez, C Millon, F Boraldi, F Garcia-Guirado, C Pedraza, E Lara, L J Santin, J Pavia, M Garcia-Fernandez
Insulin-like growth factor-II (IGF-II) is a naturally occurring hormone that exerts neurotrophic and neuroprotective properties in a wide range of neurodegenerative diseases and ageing. Accumulating evidence suggests that the effects of IGF-II in the brain may be explained by its binding to the specific transmembrane receptor, IGFII/M6P receptor (IGF-IIR). However, relatively little is known regarding the role of IGF-II through IGF-IIR in neuroprotection. Here, using adult cortical neuronal cultures, we investigated whether IGF-II exhibits long-term antioxidant effects and neuroprotection at the synaptic level after oxidative damage induced by high and transient levels of corticosterone (CORT)...
May 26, 2017: Redox Biology
https://www.readbyqxmd.com/read/28572803/insulin-like-growth-factor-binding-protein-6-in-rheumatoid-arthritis-a-possible-novel-chemotactic-factor
#17
Alessia Alunno, Onelia Bistoni, Mirko Manetti, Giacomo Cafaro, Valentina Valentini, Elena Bartoloni, Roberto Gerli, Arcangelo Liso
OBJECTIVES: Immune cell migration from the bloodstream to target tissues is a hallmark of rheumatoid arthritis (RA) pathogenesis. The role of chemoattractants, mainly chemokines, and their possible targeting for therapeutic purposes have been under intense investigation over the last few years but the results were not as satisfactory as expected. The insulin-like growth factor binding protein 6 (IGFBP6), a direct inhibitor of insulin-like growth factor (IGF)-II, also exerts IGF-independent effects including tumor cell migration in vitro...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28571015/insulin-like-growth-factors-and-metabolic-syndrome-in-obese-children
#18
Elena Inzaghi, Barbara Baldini Ferroli, Danilo Fintini, Armando Grossi, Valerio Nobili, Stefano Cianfarani
BACKGROUND/AIMS: Insulin-like growth factor (IGF)-I is related to cardiometabolic risk in adults, whereas the metabolic role of IGF-II is unclear. The aim of this study was to assess IGFs in obese children and correlate them with metabolic syndrome (MetS) components. METHODS: This is a retrospective study including 574 obese children (11.34 ± 3.16 years). All subjects underwent complete anthropometry and biochemical assessment. In a subgroup of 136 subjects, body composition was evaluated...
2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28562144/the-behavioral-deficits-and-cognitive-impairment-are-correlated-with-decreased-igf-ii-and-erk-in-depressed-mice-induced-by-chronic-unpredictable-stress
#19
Ya Li, Yajing Chen, Xiaoxiao Gao, Zhongqiu Zhang
AIM: To investigate the behavioral deficits, cognitive impairment and possible mechanisms induced by chronic unpredictable stress (CUS) in mice of different ages. METHODS: The behaviors and cognition were tested using the open field test, tail suspension test and the Morris water maze. The changes in the insulin-like growth factor II (IGF-II) and the extracellular signal-regulated kinase (ERK) and phosphorylation (p-ERK) in the hippocampus (HP) and prefrontal cortex (PFC) were evaluated by immunohistochemistry...
June 18, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28549738/direct-actions-of-macronutrient-components-on-goldfish-hepatopancreas-in-vitro-to-modulate-the-expression-of-ghr-i-ghr-ii-igf-i-and-igf-ii-mrnas
#20
Juan Ignacio Bertucci, Ayelén Melisa Blanco, Luis Fabián Canosa, Suraj Unniappan
In mammals and fish, somatic growth and metabolism are coordinated by the GH-IGF axis, composed of growth hormone (GH), growth hormone receptors I and II (GHR-I and GHR-II), and the insulin-like growth factors I and II (IGF-I and IGF-II). In order to determine if dietary macronutrients regulate the hepatopancreatic expression of ghr-I, ghr-II, igf-I and igf-II independently of circulating GH, organ culture experiments were conducted. Briefly, goldfish hepatopancreas sections were incubated with different doses of glucose; L-tryptophan; oleic acid; linolenic acid (LNA); eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)...
May 24, 2017: General and Comparative Endocrinology
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