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https://www.readbyqxmd.com/read/29626053/insulin-like-growth-factors-actions-on-the-skeleton
#1
Shoshana Yakar, Haim Werner, Cliff Rosen
The discovery of the growth hormone (GH)-mediated somatic factors (somatomedins), insulin-like growth factor (IGF)-I and -II, has elicited an enormous interest primarily amongst endocrinologists who study growth and metabolism. The advancement of molecular endocrinology over the past four decades enables investigators to re-examine and refine the established somatomedin hypothesis. Specifically, gene deletions, transgene overexpression, or more recently, cell-specific gene-ablations, have enabled investigators to study the effects of the Igf-I and Igf-II genes in temporal and spatial manners...
April 6, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29608953/training-memory-without-aversion-appetitive-hole-board-spatial-learning-increases-adult-hippocampal-neurogenesis
#2
Patricia Sampedro-Piquero, Román D Moreno-Fernández, M Carmen Mañas-Padilla, Sara Gil-Rodríguez, Ana Luisa Gavito, Francisco J Pavón, Carmen Pedraza, María García-Fernández, David Ladrón de Guevara-Miranda, Luis J Santín, Estela Castilla-Ortega
Learning experiences are potent modulators of adult hippocampal neurogenesis (AHN). However, the vast majority of findings on the learning-induced regulation of AHN derive from aversively-motivated tasks, mainly the water maze paradigm, in which stress is a confounding factor that affects the AHN outcome. Currently, little is known regarding the effect of appetitively-motivated training on AHN. Hence we studied how spatial learning to find food rewards in a hole-board maze modulates AHN (cell proliferation and immature neurons) and AHN-related hippocampal neuroplasticity markers (BDNF, IGF-II and CREB phosphorylation) in mice...
March 30, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29574782/rab9-dependent-autophagy-is-required-for-the-igf-iir-triggering-mitophagy-to-eliminate-damaged-mitochondria
#3
Chih-Yang Huang, Wei-Wen Kuo, Tsung-Jung Ho, Shu-Fen Chiang, Pei-Ying Pai, Jing-Ying Lin, Ding-Yu Lin, Chia-Hua Kuo, Chih-Yang Huang
Mitochondria dysfunction is the major characteristic of mitophagy, which is essential in mitochondrial quality control. However, excessive mitophagy contributes to cell death in a number of diseases, including ischemic stroke and hepatotoxicity. Insulin-like growth factor II (IGF-II) and its receptor (IGF-IIR) play vital roles in the development of heart failure during hypertension. We found that IGF-II triggers IGF-IIR receptor activation, causing mitochondria dysfunction, resulting in mitophagy, and cardiomyocyte cell death...
March 25, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29563157/role-of-igf-binding-proteins-in-regulating-igf-responses-to-changes-in-metabolism
#4
David Clemmons
The IGF binding protein family contains six members that share significant structural homology. Their principal function is to regulate the actions of IGF-I and IGF-II. These proteins are present in plasma and extracellular fluids and regulate access of both IGF-I and II to the type I IGF receptor. Additionally they have functions that are independent of their ability to bind IGFs. Each protein is regulated independently of IGF-I and IGF-II and this provides an important mechanism by which other hormones and physiologic variables can regulate IGF actions indirectly...
March 21, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29558888/the-serum-based-veristrat%C3%A2-test-is-associated-with-proinflammatory-reactants-and-clinical-outcome-in-non-small-cell-lung-cancer-patients
#5
Mary Jo Fidler, Cristina L Fhied, Joanna Roder, Sanjib Basu, Selina Sayidine, Ibtihaj Fughhi, Mark Pool, Marta Batus, Philip Bonomi, Jeffrey A Borgia
BACKGROUND: The VeriStrat test is a serum proteomic signature originally discovered in non-responders to second line gefitinib treatment and subsequently used to predict differential benefit from erlotinib versus chemotherapy in previously treated advanced non-small cell lung cancer (NSCLC). Multiple studies highlight the clinical utility of the VeriStrat test, however, the mechanistic connection between VeriStrat-poor classification and poor prognosis in untreated and previously treated patients is still an active area of research...
March 20, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29534073/deficiency-of-liver-derived-insulin-like-growth-factor-i-igf-i-does-not-interfere-with-the-skin-wound-healing-rate
#6
Ileana Ruxandra Botusan, Xiaowei Zheng, Sampath Narayanan, Jacob Grünler, Vivekananda Gupta Sunkari, Freja S Calissendorff, Ishrath Ansurudeen, Christopher Illies, Johan Svensson, John-Olov Jansson, Claes Ohlsson, Kerstin Brismar, Sergiu-Bogdan Catrina
OBJECTIVE: IGF-I is a growth factor, which is expressed in virtually all tissues. The circulating IGF-I is however derived mainly from the liver. IGF-I promotes wound healing and its levels are decreased in wounds with low regenerative potential such as diabetic wounds. However, the contribution of circulating IGF-I to wound healing is unknown. Here we investigated the role of systemic IGF-I on wound healing rate in mice with deficiency of liver-derived IGF-I (LI-IGF-I-/- mice) during normal (normoglycemic) and impaired wound healing (diabetes)...
2018: PloS One
https://www.readbyqxmd.com/read/29516906/biological-markers-as-an-outcome-measure-of-exercise-in-cancer-rehabilitation-a-systematic-review
#7
REVIEW
Lauri-Anne McDermott, Marie H Murphy, Andrea M McNeilly, Jane P Rankin, Jackie H Gracey
The number of people living with and beyond cancer is at an all time high. These survivors are not necessarily living well, as adverse side effects from cancer and its treatment can last up to 5 years and leave patients at a higher risk of developing secondary cancers and other chronic illnesses. Exercise has been proven to be a safe and effective method of intervention to decrease mortality and overall improve health outcomes. The biological mechanism through which this occurs is an area of research that is in its infancy and not well defined...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29515523/igf-binding-protein-5-induces-cell-senescence
#8
REVIEW
Fumihiro Sanada, Yoshiaki Taniyama, Jun Muratsu, Rei Otsu, Hideo Shimizu, Hiromi Rakugi, Ryuichi Morishita
Cellular senescence is the complex process of deterioration that drives the aging of an organism, resulting in the progressive loss of organ function and eventually phenotypic aging. Senescent cells undergo irreversible growth arrest, usually by inducing telomere shortening. Alternatively, senescence may also occur prematurely in response to various stress stimuli, such as oxidative stress, DNA damage, or activated oncogenes. Recently, it has been shown that IGF binding protein-5 (IGFBP-5) with the induction of the tumor suppressor p53 is upregulated during cellular senescence...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29499628/in-vivo-inhibition-of-nuclear-factor-of-activated-t-cells-leads-to-atherosclerotic-plaque-regression-in-igf-ii-ldlr-apob-100-100-mice
#9
Fabiana Blanco, Suvi E Heinonen, Erika Gurzeler, Lisa M Berglund, Anna-Maria Dutius Andersson, Olga Kotova, Ann-Cathrine Jönsson-Rylander, Seppo Ylä-Herttuala, Maria F Gomez
AIMS: Despite vast clinical experience linking diabetes and atherosclerosis, the molecular mechanisms leading to accelerated vascular damage are still unclear. Here, we investigated the effects of nuclear factor of activated T-cells inhibition on plaque burden in a novel mouse model of type 2 diabetes that better replicates human disease. METHODS & RESULTS: IGF-II/LDLR-/- ApoB100/100 mice were generated by crossbreeding low-density lipoprotein receptor-deficient mice that synthesize only apolipoprotein B100 (LDLR-/- ApoB100/100 ) with transgenic mice overexpressing insulin-like growth factor-II in pancreatic β cells...
March 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29492361/non-islet-cell-tumor-hypoglycemia-a-rare-cause-of-hypoglycemia-in-pulmonary-sarcomatoid-cancer
#10
Timothy B Legare, Oteni Hamilton, Sarah Dhannoon, Sayed Ali
Non-islet cell tumor hypoglycemia (NICTH) is a rare paraneoplastic condition caused most commonly by metastatic mesenchymal tumors. A 74-year-old non-diabetic male with an eight-year history of metastatic sarcomatoid lung cancer presented with altered mental status. His previous treatment included a lobectomy and radiation. Laboratory investigations were significant for blood glucose of 28 mg/dL, confirming hypoglycemia. He was hypokalemic, a condition seen in approximately 50% of patients with NICTH, at 2...
December 20, 2017: Curēus
https://www.readbyqxmd.com/read/29487569/effects-of-transport-duration-and-environmental-conditions-in-winter-or-summer-on-the-concentrations-of-insulin-like-growth-factors-and-insulin-like-growth-factor-binding-proteins-in-the-plasma-of-market-weight-pigs
#11
Elisa Wirthgen, Sébastien Goumon, Martin Kunze, Christina Walz, Marion Spitschak, Armin Tuchscherer, Jennifer Brown, Christine Höflich, Luigi Faucitano, Andreas Hoeflich
In previous work using market-weight pigs, we had demonstrated that insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) are regulated during shipment characterized by changing conditions of stress due to loading or unloading, transportation, lairage, and slaughter. In addition, we found in a previous study that IGFBP-2 concentrations were lower in pigs transported for longer periods of time. Therefore, we performed a more detailed study on the effects of transport duration and season on the plasma concentrations of IGFs and IGFBPs in adult pigs...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29409593/roles-of-insulin-like-growth-factors-in-metamorphic-development-of-turbot-scophthalmus-maximus
#12
REVIEW
Yudong Jia
Larval turbot (Scophthalmus maximus) undergo metamorphosis, a late post-embryonic developmental event that precedes juvenile transition. Insulin-like growth factors (IGFs) are important endocrine/autocrine/paracrine factors that provide essential signals to control of the embryonic and postnatal development of vertebrate species, including fish. Accumulating evidence suggests that IGFs are involved in regulating the metamorphic development of flatfish. This mini review focus on the functions of all known IGFs (IGF-I and IGF-II) during the metamorphic development of turbot...
January 31, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29408008/takifugu-rubripes-cation-independent-mannose-6-phosphate-receptor-cloning-expression-and-functional-characterization-of-the-igf-ii-binding-domain
#13
A Ajith Kumar, Siva Kumar Nadimpalli
Mannose 6-phosphate/IGF-II receptor mediated lysosomal clearance of insulin like growth factor-II is significantly associated with the evolution of placental mammals. The protein is also referred to as the IGF-II receptor. Earlier studies suggested relatively low binding affinity between the receptor and ligand in prototherian and metatherian mammals. In the present study we cloned the IGF-II binding domain of the early vertebrate fugu fish and expressed it in bacteria. A 72000 Da truncated receptor containing the IGF-II binding domain was obtained...
January 30, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29402777/correlation-of-insulin-like-growth-factor-i-and-ii-concentrations-at-birth-measured-by-mass-spectrometry-and-growth-from-birth-to-two-months
#14
Colin P Hawkes, Deirdre M Murray, Louise C Kenny, Mairead Kiely, Jonathan O'B Hourihane, Alan D Irvine, Zengru Wu, Yair Argon, Richard E Reitz, Michael J McPhaul, Adda Grimberg
BACKGROUND: Immunoassays used to measure insulin-like growth factor (IGF)-I and -II concentrations are susceptible to interference from IGF-binding proteins. The aim of this study was to investigate the association of IGF-I and -II concentrations at birth with neonatal anthropometry using a liquid chromatography/mass spectrometry (LCMS) assay. METHODS: LCMS was used to measure IGF-I and -II concentrations in umbilical cord blood of term, healthy infants enrolled in the Cork BASELINE Birth Cohort Study...
January 18, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29331388/e4bp4-inhibits-angii-induced-apoptosis-in-h9c2-cardiomyoblasts-by-activating-the-pi3k-akt-pathway-and-promoting-calcium-uptake
#15
Bih-Cheng Chen, Marthandam Asokan Shibu, Chia-Hua Kuo, Chia-Yao Shen, Shu Nu Chang-Lee, Chao-Hung Lai, Ray-Jade Chen, Chun-Hsu Yao, Vijaya Padma Viswanadha, Jian-Shen Liu, Wei-Kung Chen, Chih-Yang Huang
The bZIP transcription factor E4BP4 is a survival factor that is known to be elevated in diseased heart and promote cell survival. In this study the role of E4BP4 on angiotensin-II (AngII)-induced apoptosis has been examined in in vitro cell model. H9c2 cardiomyoblast cells that overexpressed E4BP4 were exposed to AngII to observe the cardio-protective effects of E4BP4 on hypertension related apoptosis. The results from TUNEL assays revealed that E4BP4 significantly attenuated AngII-induced apoptosis. Further analysis by Western blot and RT-PCR showed that E4BP4 inhibited AngII-induced IGF-II mRNA expression and cleavage of caspase-3 through the PI3K-Akt pathway...
February 15, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29311590/vitamin-a-and-e-nutritional-status-in-relation-to-leptin-adiponectin-igf-i-and-igf-ii-in-early-life-a-birth-cohort-study
#16
Qinwen Du, Zhong-Cheng Luo, Anne Monique Nuyt, Francois Audibert, Pierre Julien, Shu-Qin Wei, Dan-Li Zhang, William Fraser, Emile Levy
The metabolic health effects of vitamin A and E nutritional status in early life are largely unknown. We assessed whether vitamin A and vitamin E nutritional status may affect circulating leptin, adiponectin, insulin-like growth factor (IGF)-I and IGF-II levels in early life in humans. In a singleton birth cohort (n = 248), vitamin A and E nutritional status in fetuses/newborns were assessed by cord plasma concentrations of retinol, β-carotene, α- and γ-tocopherols. The primary outcomes were cord plasma leptin, adiponectin, IGF-I and IGF-II concentrations...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29277338/hypothalamic-abnormalities-growth-failure-due-to-defects-of-the-ghrh-receptor
#17
Manuel H Aguiar-Oliveira, Caridad Davalos, Viviane C Campos, Luiz A Oliveira Neto, Cindi G Marinho, Carla R P Oliveira
Several acquired or congenital hypothalamic abnormalities may cause growth failure (GF). We described two of these congenital abnormalities. First, a case of CHARGE syndrome, an epigenetic disorder mostly caused by heterozygous mutations in the gene encoding CHD7, a chromatin remodeling protein, causing several malformations, some life-threatening, with additional secondary hypothalamus-hypophyseal dysfunction, including GF. Second, a cohort of individuals with genetic isolated severe GH deficiency (IGHD), due to a homozygous mutation in the GH-releasing hormone (GHRH) receptor gene described in Itabaianinha County, in northeast Brazil...
February 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29250665/the-correlation-between-insulin-like-growth-factor-with-glycemic-control-glomerular-filtration-rate-blood-pressure-hematological-changes-or-body-mass-index-in-patients-with-type-2-diabetes-mellitus
#18
Marius Cristian NeamŢu, Elena Taina Avramescu, Iulia Rahela Marcu, Adina Turcu-Ştiolică, Mihail Virgil Boldeanu, Oana Maria NeamŢu, Ştefania Tudorache, Rucsandra Elena Dănciulescu Miulescu
Insulin-like growth factor (IGF) family is made up of two polypeptides, IGF-I and IGF-II, six specific binding proteins (IGFBPs 1-6) and specific receptors. IGF-I is involved in the regulation of growth and cellular proliferation and has a similar structure to insulin. The major IGF transport function is attributed to IGFBP-3. Some studies have highlighted the association between IGF and diabetes. The aims of this study were to analyze the correlation between IGF with glycemic control, glomerular filtration rate (GFR), blood pressure, hematological changes or body mass index (BMI) in patients with type 2 diabetes mellitus (T2DM)...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29245946/mir-483-5p-promotes-igf-ii-transcription-and-is-associated-with-poor-prognosis-of-hepatocellular-carcinoma
#19
Shaohui Tang, Yanfang Chen, Shufen Feng, Tingzhuang Yi, Xuyou Liu, Qiang Li, Zhilong Liu, Cuiping Zhu, Jianjun Hu, Xi Yu, Min Wang, Guoli Cao, Hui Tang, Caiqun Bie, Feng Ma, Huijun Tang, Gang Du, Jianwei Huang
The human insulin-like growth factor-II (IGF-II) gene transcribes four mRNAs (P1 mRNA-P4 mRNA), and P3 mRNA overexpression contributes to hepatocarcinogenesis. IGF-II-derived miR-483-5p is implicated in the development of cancers. Here, we investigated the involvement of miR-483-5p in P3 mRNA overexpression regulation and its role in hepatocellular carcinoma. Our results showed that miR-483-5p up-regulated P3 mRNA transcription by targeting the 5'-untranslated region (5'UTR) of P3 mRNA in hepatocellular carcinoma...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29233839/genetics-of-tumors-of-the-adrenal-cortex
#20
REVIEW
Fidéline Bonnet-Serrano, Jérôme Bertherat
This review describes the molecular alterations observed in the various types of tumors of the adrenal cortex, excluding Conn adenomas, especially the alterations identified by genomic approaches these last five years. Two main forms of bilateral adrenocortical tumors can be distinguished according to size and aspect of the nodules: primary pigmented nodular adrenal disease (PPNAD), which can be sporadic or part of Carney complex and primary bilateral macro nodular adrenal hyperplasia (PBMAH). The bilateral nature of the tumors suggests the existence of an underlying genetic predisposition...
March 2018: Endocrine-related Cancer
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