Liao Peng, Jia-Wei Chen, Yuan-Zhuo Chen, Chi Zhang, Si-Hong Shen, Meng-Zhu Liu, Yang Fan, Shi-Qin Yang, Xiu-Zhen Zhang, Wei Wang, Xiao-Shuai Gao, Xing-Peng Di, Yu-Cheng Ma, Xiao Zeng, Hong Shen, Xi Jin, De-Yi Luo
Urothelial damage and barrier dysfunction emerge as the foremost mechanisms in Hunner-type interstitial cystitis/bladder pain syndrome (HIC). Although treatments aimed at urothelial regeneration and repair have been employed, their therapeutic effectiveness remains limited due to the inadequate understanding of specific cell types involved in damage and the lack of specific molecular targets within these mechanisms. Therefore, we harnessed single-cell RNA sequencing to elucidate the heterogeneity and developmental trajectory of urothelial cells within HIC bladders...
March 29, 2024: Journal of Pathology