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https://www.readbyqxmd.com/read/28096651/effects-of-3-diquafosol-sodium-ophthalmic-solution-on-higher-order-aberrations-in-patients-diagnosed-with-dry-eye-after-cataract-surgery
#1
Yasushi Inoue, Shintarou Ochi
PURPOSE: To evaluate the effects of diquafosol sodium ophthalmic solution 3% (DQS) and artificial tears (AT) on higher-order aberrations (HOAs) in patients with dry eye after cataract surgery. DESIGN: This was a post hoc analysis of a previously conducted randomized clinical study. METHODS: Fifty-nine eyes from 42 patients (17 males and 25 females, aged 72.6±8.0 years) with verified or suspected dry eye at 4 weeks after cataract surgery were evaluated...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28096589/water-cooled-radiofrequency-neuroablation-for-sacroiliac-joint-dysfunctional-pain
#2
Binay Kumar Biswas, Samarjit Dey, Saumya Biswas, Varinder Kumar Mohan
Sacroiliac (SI) joint dysfunction is a common source of chronic low-back pain. Recent evidences from different parts of the world suggest that cooled radiofrequency (RF) neuroablation of sacral nerves supplying SI joints has superior pain alleviating properties than available existing treatment options for SI joint dysfunctional pain. A 35-year-old male had intractable bilateral SI joint pain (numeric rating scale [NRS] - 9/10) with poor treatment response to intra-articular steroid therapy. Bilateral water cooled = RF was applied for neuroablation of nerves supplying both SI joints...
October 2016: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/28093890/long-term-follow-up-for-treatment-of-erectile-dysfunction-post-radical-prostatectomy-using-nerve-grafts-and-end-to-side-somatic-autonomic-neurorraphy-a-new-technique
#3
José Carlos Souza Trindade, Fausto Viterbo, André Petean Trindade, Wagner José Fávaro, José Carlos Souza Trindade Filho
: Radical prostatectomy (RP) for prostate cancer treatment, although effective, can lead to severe erectile dysfunction. This study describes a new technique, which aims to reestablish the nerve stimulus in penile erection by two sural nerve graft bridges bilaterally, using the end to side neurorraphy. The first bridge is between femoral nerve and dorsal nerve of penis and the second, is between the femoral nerve and the interior of the corpus cavernosum. In this neurorraphy the endings of the newly formed fibres, generated by the femoral nerve, release acetylcholine inside the cavernous bodies, beginning the erection mechanism...
January 17, 2017: BJU International
https://www.readbyqxmd.com/read/28055012/aif-independent-parthanatos-in-the-pathogenesis-of-dry-age-related-macular-degeneration
#4
Ki-Hong Jang, Yun-Ju Do, Dongwon Son, Eunji Son, Jun-Sub Choi, Eunhee Kim
Cell death of retinal pigment epithelium (RPE) is characterized as an essential late-stage phenomenon of dry age-related macular degeneration (AMD). The aim of this study was to elucidate the molecular mechanism underlying RPE cell death after exposure to oxidative stress, which occurs often because of the anatomical location of RPE cells. ARPE-19, an established RPE cell line, exhibited necrotic features involving poly (ADP-ribose) polymerase-1 (PARP-1) activation in response to hydrogen peroxide (H2O2). ARPE-19 cells were resistant to H2O2 when PARP-1 was depleted using siRNA or inhibited by a pharmacological inhibitor of PARP-1, olaparib...
January 5, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28041981/maternal-exposure-to-fine-particulate-air-pollution-induces-epithelial-to-mesenchymal-transition-resulting-in-postnatal-pulmonary-dysfunction-mediated-by-transforming-growth-factor-%C3%AE-smad3-signaling
#5
Wenting Tang, Lili Du, Wen Sun, Zhiqiang Yu, Fang He, Jingsi Chen, Xiaomei Li, Xiuying Li, Lin Yu, Dunjin Chen
Fine particles from air pollution, also called particulate matter, less than 2.5 micrometers in diameter (PM2.5), are a threat to child health. Epidemiological investigations have related maternal exposure to PM2.5 to postnatal respiratory symptoms, such as frequent wheezing, chronic cough, and lung function decrements. However, only few experimental animal studies have been performed to study the effects of PM2.5.The aim of this study was to investigate the effects of maternal exposure to PM2.5 on postnatal pulmonary dysfunction in a rat model and to examine the mechanism of PM2...
December 29, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/28006020/albuminuria-is-associated-with-open-angle-glaucoma-in-nondiabetic-korean-subjects-a-cross-sectional-study
#6
Gyu Ah Kim, Se Hee Park, Jaesang Ko, Si Hyung Lee, Hyoung Won Bae, Gong Je Seong, Chan Yun Kim
OBJECTIVE: Systemic vascular dysfunction has been suggested to contribute to glaucomatous damage. Albuminuria is a surrogate marker of endothelial injury, including vessels. However, their relationship is not well understood. This study aimed to investigate the association between albuminuria and the prevalence of open-angle glaucoma (OAG) in nondiabetic subjects. METHODS: We conducted a cross-sectional study of 4186 nondiabetic participants aged 19 years or older from the 2011-2012 Korea National Health and Nutrition Examination Survey...
2016: PloS One
https://www.readbyqxmd.com/read/27976725/modulation-of-gut-microbiota-and-delayed-immunosenescence-as-a-result-of-syringaresinol-consumption-in-middle-aged-mice
#7
Si-Young Cho, Juewon Kim, Ji Hae Lee, Ji Hyun Sim, Dong-Hyun Cho, Il-Hong Bae, Hyunbok Lee, Min A Seol, Hyun Mu Shin, Tae-Joo Kim, Dae-Yong Kim, Su-Hyung Lee, Song Seok Shin, Sin-Hyeog Lm, Hang-Rae Kim
Age-associated immunological dysfunction (immunosenescence) is closely linked to perturbation of the gut microbiota. Here, we investigated whether syringaresinol (SYR), a polyphenolic lignan, modulates immune aging and the gut microbiota associated with this effect in middle-aged mice. Compared with age-matched control mice, SYR treatment delayed immunosenescence by enhancing the numbers of total CD3(+) T cells and naïve T cells. SYR treatment induced the expression of Bim as well as activation of FOXO3 in Foxp3(+) regulatory T cells (Tregs)...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27930947/ginseng-and-obesity-observations-and-understanding-in-cultured-cells-animals-and-humans
#8
REVIEW
Longyun Zhang, Carlos Virgous, Hongwei Si
Ginseng, a traditional medical herb, has been reported having beneficial effects in fatigue, heart diseases, diabetes, immune function and erectile dysfunction. In recent years, increasing investigations have been conducted on ginseng in preventing and treating of obesity, one of the major worldwide escalating public health concerns. However, the effect and the relevant mechanisms behind how ginseng works as an antiobesity treatment are still controversial. In this review, we briefly discussed the chemical structures, metabolism and pharmacokinetics of ginseng and its major bioactive components ginsenosides...
November 23, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27900677/downregulation-of-the-long-non-coding-rna-meg3-promotes-angiogenesis-after-ischemic-brain-injury-by-activating-notch-signaling
#9
Juan Liu, Qing Li, Kun-Shan Zhang, Bin Hu, Xin Niu, Shu-Min Zhou, Si-Guang Li, Yu-Ping Luo, Yang Wang, Zhi-Feng Deng
Angiogenesis after ischemic brain injury contributes to the restoration of blood supply in the ischemic zone. Strategies to improve angiogenesis may facilitate the function recovery after stroke. Recent researches have demonstrated that dysfunction of long non-coding RNAs are associated with angiogenesis. We have previously reported that long non-coding RNAs (lncRNAs) are aberrantly expressed in ischemic stroke. However, little is known about long non-coding RNAs and theirs role in angiogenesis after stroke...
November 29, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27884145/estimation-of-the-cool-executive-function-using-frontal-electroencephalogram-signals-in-first-episode-schizophrenia-patients
#10
Yi Yu, Yun Zhao, Yajing Si, Qiongqiong Ren, Wu Ren, Changqin Jing, Hongxing Zhang
BACKGROUND: In schizophrenia, executive dysfunction is the most critical cognitive impairment, and is associated with abnormal neural activities, especially in the frontal lobes. Complexity estimation using electroencephalogram (EEG) recording based on nonlinear dynamics and task performance tests have been widely used to estimate executive dysfunction in schizophrenia. METHODS: The present study estimated the cool executive function based on fractal dimension (FD) values of EEG data recorded from first-episode schizophrenia patients and healthy controls during the performance of three cool executive function tasks, namely, the Trail Making Test-A (TMT-A), Trail Making Test-B (TMT-B), and Tower of Hanoi tasks...
November 25, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/27849332/pulmonary-microvascular-dysfunction-and-pathological-changes-induced-by-blast-injury-in-a-rabbit-model
#11
Si Yu Wu, Geng Fen Han, Jian Yi Kang, Liang Chao Zhang, Ai Min Wang, Jian Min Wang
BACKGROUND: Vascular leakage has been proven to play a critical role in the incidence and development of explosive pulmonary barotrauma. Quantitatively investigated in the present study was the severity of vascular leakage in a gradient blast injury series, as well as ultrastructural evidence relating to pulmonary vascular leakage. METHODS: One hundred adult male New Zealand white rabbits were randomly divided into 5 groups according to distance from the detonator (10 cm, 15 cm, 20 cm, 30 cm, and sham control)...
September 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/27822944/swallowing-function-defined-by-videofluoroscopic-swallowing-studies-after-anterior-cervical-discectomy-and-fusion-a-prospective-study
#12
Si Hyun Kang, Don Kyu Kim, Kyung Mook Seo, Sang Yoon Lee, Seung Won Park, Yong Baeg Kim
This study evaluated factors related to swallowing dysfunction after anterior cervical discectomy and fusion (ACDF) using videofluoroscopic swallowing studies (VFSS). Preoperative and postoperative VFSSs were done with 5 mL diluted barium. Oral transit time, pharyngeal delay time, pharyngeal response time (PRT), and pharyngeal transit time were measured. Hyoid bone movement and upper esophageal sphincter (UES) diameter were measured serially. Thickness of prevertebral soft tissue was measured from digitized VFSS images...
December 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27819530/cationic-liposomes-induce-cell-necrosis-through-lysosomal-dysfunction-and-late-stage-autophagic-flux-inhibition
#13
Kaixuan Yang, Ying Lu, Fangyuan Xie, Hao Zou, Xiaoyu Fan, Bohua Li, Wei Li, Wei Zhang, Lin Mei, Si-Shen Feng, You Yin, Yan Liu, Hai Zhang, Chuan Yin, Yanqiang Zhong, Jie Gao
AIM: The application of cationic liposomes (CLs) as nonviral vectors is hampered by their cellular toxicity. Thus we aim to investigate the mechanisms underlying the cellular toxicity of CLs. MATERIALS & METHODS: The effect of CLs on the autophagic flux, autophagosome-lysosome fusion, lysosome membrane permeabilization and cell necrosis of liver cells was investigated. RESULTS & CONCLUSION: Our results reveal a novel mechanism of CL-induced cell necrosis involving the induction of lysosome membrane permeabilization and late-stage autophagic flux inhibition that resulted in cytoplasmic release of cathepsin B, mitochondrial dysfunction and reactive oxygen species production, which are the key mediators of cell necrosis...
November 7, 2016: Nanomedicine
https://www.readbyqxmd.com/read/27791092/pde1c-deficiency-antagonizes-pathological-cardiac-remodeling-and-dysfunction
#14
Walter E Knight, Si Chen, Yishuai Zhang, Masayoshi Oikawa, Meiping Wu, Qian Zhou, Clint L Miller, Yujun Cai, Deanne M Mickelsen, Christine Moravec, Eric M Small, Junichi Abe, Chen Yan
Cyclic nucleotide phosphodiesterase 1C (PDE1C) represents a major phosphodiesterase activity in human myocardium, but its function in the heart remains unknown. Using genetic and pharmacological approaches, we studied the expression, regulation, function, and underlying mechanisms of PDE1C in the pathogenesis of cardiac remodeling and dysfunction. PDE1C expression is up-regulated in mouse and human failing hearts and is highly expressed in cardiac myocytes but not in fibroblasts. In adult mouse cardiac myocytes, PDE1C deficiency or inhibition attenuated myocyte death and apoptosis, which was largely dependent on cyclic AMP/PKA and PI3K/AKT signaling...
October 20, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27784025/arterial-stiffness-and-cardiovascular-autonomic-dysfunction-in-patients-with-parkinson-s-disease
#15
Joong-Seok Kim, Si-Hoon Lee, Yoon-Sang Oh, Jeong-Wook Park, Jae-Young An, Hyun-Seok Choi, Kwang-Soo Lee
BACKGROUND: Pulse wave velocity is a marker of arterial stiffness and a surrogate marker of vascular damage. Autonomic abnormalities associated with blood pressure are relatively commonly observed in patients with Parkinson's disease (PD). OBJECTIVE: The purpose of this study was to compare arterial stiffness between patients with PD and controls and investigate the associations between cardiovascular autonomic dysfunction and pulse wave velocity in PD. METHODS: One hundred twenty-five PD patients without diabetes mellitus were enrolled into this study, along with 22 age-matched controls...
October 27, 2016: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/27777214/-effect-of-covered-stent-length-in-portal-and-hepatic-veins-on-long-term-clinical-efficacy-of-transjugular-intrahepatic-portosystemic-shunt
#16
Peng Hu, Si-Liang Chen, Zhi-Peng Lin, Jian-Bo Zhao, Yong Chen, Xiao-Feng He, Qing-le Zeng, Yan-Hao Li
OBJECTIVE: To evaluate the effect of the length of covered stents in the portal and hepatic veins on long-term clinical efficacy of transjugular intrahepatic portosystemic shunt (TIPS). METHODS: We retrospectively reviewed 53 cases receiving TIPSs between January, 2008 and December, 2011. All the shunts were created with Fluency stents (8 mm in diameter). Bare metal grafts of the same diameter were implanted to extend the length in the portal and hepatic veins as deemed necessary according to angiographic images...
October 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27769859/chop-deficiency-inhibits-methylglyoxal-induced-endothelial-dysfunction
#17
Yoon Young Choi, Suji Kim, Jung-Hwa Han, Dae-Hwan Nam, Kwon Moo Park, Seong Yong Kim, Chang-Hoon Woo
Epidemiological studies suggested that diabetic patients are susceptible to develop cardiovascular complications along with having endothelial dysfunction. It has been suggested that methylglyoxal (MGO), a glycolytic metabolite, has more detrimental effects on endothelial dysfunction rather than glucose itself. Here, we investigated the molecular mechanism by which MGO induces endothelial dysfunction via the regulation of ER stress. Biochemical data showed that 4-PBA significantly inhibited MGO-induced protein cleavages of PARP-1 and caspase-3...
October 18, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27746815/disproportionately-elevated-proinsulin-levels-as-an-early-indicator-of-%C3%AE-cell-dysfunction-in-nondiabetic-offspring-of-chinese-diabetic-patients
#18
Ming Li, Dan Feng, Kui Zhang, Shan Gao, Juming Lu
Objective. To study the characteristics of β-cell dysfunction and insulin resistance (IR) in the first-degree relatives (FDRs) of T2DM in Chinese population and to examine the usefulness of proinsulin (PI) for evaluating β-cell dysfunction. Methods. 229 subjects of nondiabetic FDRs, 71 newly diagnosed T2DM, and 114 with normal glucose tolerance (NGT) but not FDRs (NGT-non-FDRs) were verified by a 2-hour oral glucose tolerance test. Specific insulin (SI) and PI were measured by highly sensitive ELISA. Results...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27744232/chinese-version-of-the-psychotropic-related-sexual-dysfunction-questionnaire-prsexdq-salsex-validity-and-reliability-for-schizophrenic-patients-taking-antipsychotics
#19
Yu-Xi Wang, Ping Zhang, Li-Min Xin, Lin Chen, Yan-Hong Liu, Yun-Ai Su, Tian-Mei Si
This study was designed to examine the validity and reliability of the Chinese version of the Psychotropic-Related Sexual Dysfunction Questionnaire (PRSexDQ-SALSEX) in patients with schizophrenia taking antipsychotics. It was conducted in a sample of 135 patients aged between 18 and 50 years old and diagnosed with schizophrenia. Demographic data and clinical features were assessed with PRSexDQ, the Positive and Negative Syndrome Scale (PANSS), the Clinical Global Impression (CGI), and the Udvalg for Kliniske Undersøgelser (UKU) Side Effects Rating Scale...
December 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27738803/preventive-effects-of-dexmedetomidine-on-the-development-of-cognitive-dysfunction-following-systemic-inflammation-in-aged-rats
#20
Daiki Yamanaka, Takashi Kawano, Atsushi Nishigaki, Bun Aoyama, Hiroki Tateiwa, Marie Shigematsu-Locatelli, Fabricio M Locatelli, Masataka Yokoyama
PURPOSE: In the present study, we examined whether and by what mechanisms dexmedetomidine (DMED) prevents the development of systemic inflammation (SI)-induced cognitive dysfunction in aged rats. METHODS: Animals received a single intraperitoneal (i.p.) injection of either 5.0 mg/kg lipopolysaccharide (LPS) or vehicle. LPS-treated rats were further divided into three groups: early DMED, late DMED, or midazolam (MDZ) treatment (n = 12 each). Seven days after LPS injection, cognitive function was evaluated using a novel object recognition task, followed by measurement of hippocampal levels of proinflammatory cytokines and Toll-like receptor 4 (TLR-4) expression...
October 13, 2016: Journal of Anesthesia
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