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https://www.readbyqxmd.com/read/29137101/analysis-of-islet-beta-cell-functions-and-their-correlations-with-liver-dysfunction-in-patients-with-neonatal-intrahepatic-cholestasis-caused-by-citrin-deficiency-niccd
#1
Chun-Ting Lu, Jing Yang, Si-Min Huang, Lie Feng, Ze-Jian Li
Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) primarily manifests in neonates or infants with hepatomegaly, liver dysfunction, and hypoglycemia. This study investigated the functions of islet beta cells and their correlations with liver dysfunction in NICCD patients.We retrospectively analyzed clinical data on liver function and islet beta cell functions for 36 patients diagnosed with NICCD and 50 subjects as the control group. The NICCD group had significantly higher total bilirubin (TBIL), direct bilirubin (DBIL), alanine aminotransferase (ALT), aspartate amino transferase (AST), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP) and alpha-fetoprotein (AFP) levels and albumin/globulin ratio (A/G) (P < ...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29126197/impaired-insulin-action-is-associated-with-increased-glucagon-concentrations-in-non-diabetic-humans
#2
Anu Sharma, Ron T Varghese, Meera Shah, Chiara Dalla Man, Claudio Cobelli, Robert A Rizza, Kent R Bailey, Adrian Vella
Context: Abnormal glucagon concentrations contribute to hyperglycemia but the mechanism(s) of α-cell dysfunction in prediabetes are unclear. Objective: We sought to determine the relative contributions of insulin secretion and action to α-cell dysfunction in non-diabetic subjects across the spectrum of glucose tolerance. Design: This was a cross-sectional study. A subset of subjects (n = 120) was studied in the presence and absence of free fatty acid (FFA) elevation, achieved by infusion of intralipid + heparin, to cause insulin resistance...
November 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29124661/valsartan-regulates-tgf-%C3%AE-smads-and-tgf-%C3%AE-p38-pathways-through-lncrna-chrf-to-improve-doxorubicin-induced-heart-failure
#3
Lei Chen, Kui-Po Yan, Xin-Can Liu, Wei Wang, Chao Li, Ming Li, Chun-Guang Qiu
This study investigated the interaction among valsartan (VAL), TGF-β pathways, and long non-coding RNA (lncRNA) cardiac hypertrophy-related factor (CHRF) in doxorubicin (DOX)-induced heart failure (HF), and explored their roles in DOX-induced HF progression. HF mice models in vivo were constructed by DOX induction. The expression of CHRF and TGF-β1 in hearts was detected, along with cardiac function, caspase-3 activity, and cell apoptosis. Primary myocardial cells were pretreated with VAL, followed by DOX induction in vitro for functional studies, including the detection of cell apoptosis with terminal deoxynucleotidyl transferase dUTP nick-end labeling and the expression of proteins associated with TGF-β1 pathways...
November 9, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29115483/hepatocellular-toxicity-of-oxalicumone-a-via-oxidative-stress-injury-and-mitochondrial-dysfunction-in-healthy-human-liver-cells
#4
Si Shi, Limei Yao, Kunbin Guo, Xiangyu Wang, Qi Wang, Weirong Li
The marine‑derived oxalicumone A (POA) has been demonstrated as a potent anti‑tumor bioactive agent for a variety of human carcinoma, but to the best of our knowledge, remains to be evaluated in healthy liver cells. As many drugs distribute preferentially in the liver, the present study aimed to investigate the effects of POA on apoptosis, oxidative stress and mitochondrial function in L‑02 healthy liver cells. A Cell‑Counting kit‑8 assay demonstrated that POA inhibits the proliferation of L‑02 cells in a dose‑ and time‑dependent manner...
November 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29111293/serum-levels-of-melatonin-may-contribute-to-the-pathogenesis-of-heart-failure-in-children-with-median-age-of-1-year
#5
Yao Wu, Feifei Si, Li Luo, Qijian Yi
OBJECTIVE: Melatonin has a protective role in adults with cardiovascular disease, but the effects of melatonin in children with cardiac dysfunction are not well understood. This study was designed to explore the variations in melatonin, myeloperoxidase, and caspase-3 levels in children suffering from heart failure. METHODS: Seventy-two pediatric patients with heart failure and twelve healthy children were enrolled in this study. A modified Ross scoring system was used to evaluate clinical cardiac function...
October 28, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/29076204/variation-in-nurse-self-reported-practice-of-managing-chest-tubes-a-cross-sectional-study
#6
Cui Lu, Ying-Hui Jin, Weijie Gao, Yue-Xian Shi, Xinhua Xia, Wen-Xi Sun, Qi Tang, Yunyun Wang, Ge Li, Jinhua Si
AIMS AND OBJECTIVES: This study aims to reveal nurses' self-reported practice of managing chest tubes and to define decision-makers for these practices. BACKGROUND: No consensus exists regarding ideal chest-tube management strategy, and there are wide variations of practice based on local policies and individual preferences, rather than standardized evidence-based protocols. DESIGN: This article describes a cross-sectional study. METHODS: Questionnaires were emailed to 31 hospitals in Tianjin, and the sample consisted of 296 clinical nurses whose work included nursing management of chest drains...
October 27, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29066253/roselle-is-cardioprotective-in-diet-induced-obesity-rat-model-with-myocardial-infarction
#7
Lislivia Yiang-Nee Si, Siti Aishah Mohd Ali, Jalifah Latip, Norsyahida Mohd Fauzi, Siti Balkis Budin, Satirah Zainalabidin
AIMS: Obesity increase the risks of hypertension and myocardial infarction (MI) mediated by oxidative stress. This study was undertaken to investigate the actions of roselle aqueous extract (R) on cardiotoxicity in obese (OB) rats and thereon OB rats subjected to MI. MAIN METHODS: Male Sprague-Dawley rats were fed with either normal diet or high-fat diet for 8weeks. Firstly, OB rats were divided into (1) OB and (2) OB+R (100mg/kg, p.o, 28days). Then, OB rats were subjected to MI (ISO, 85mg/kg, s...
December 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/29061338/ctrp3-protected-against-doxorubicin-induced-cardiac-dysfunction-inflammation-and-cell-death-via-activation-of-sirt1
#8
Yu-Pei Yuan, Zhen-Guo Ma, Xin Zhang, Si-Chi Xu, Xiao-Feng Zeng, Zheng Yang, Wei Deng, Qi-Zhu Tang
BACKGROUND: Inflammation and myocytes apoptosis play critical roles in the development of doxorubicin (DOX)-induced cardiotoxicity. Our previous study found that C1q/tumour necrosis factor-related protein-3 (CTRP3) could inhibit cardiac inflammation and apoptosis of myocytes but its role in DOX-induced heart injury remains largely unknown. Our study aimed to investigate whether CTRP3 protected against DOX-induced heart injury and the underlying mechanism. METHODS: We overexpressed CTRP3 in the hearts using an adeno-associated virus system...
October 20, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29058292/danshen-modulates-nrf2-mediated-signaling-pathway-in-cisplatin-induced-renal-injury
#9
Si-Si Cao, Miao Yan, Zhen-Yan Hou, Ying Chen, Yun-Sheng Jiang, Xin-Rong Fan, Ping-Fei Fang, Bi-Kui Zhang
Danshen, an efficacious agent for cardiovascular diseases, has been found to play an essential role in kidney injury. In the present study, the effect of Danshen on cisplatin-induced renal dysfunction was investigated in a mouse model. Danshen was administered to mice at a dose of 3 g/kg 4 days before and 3 days after cisplatin treatment. A single intraperitoneal injection of 20 mg/kg cisplatin was used to induce nephrotoxicity. The mice were sacrificed 72 h after cisplatin intoxication. Biochemical parameters including serum creatinine and blood urea nitrogen were analyzed...
October 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/29045568/loss-of-protein-kinase-novel-1-pkn1-is-associated-with-mild-systolic-and-diastolic-contractile-dysfunction-increased-phospholamban-thr17-phosphorylation-and-exacerbated-ischaemia-reperfusion-injury
#10
Asvi A Francois, Kofo Obasanjo-Blackshire, James E Clark, Andrii Boguslavskyi, Mark R Holt, Peter Parker, Michael S Marber, Richard J Heads
Aims: PKN1 is a stress-responsive protein kinase acting downstream of small GTP-binding proteins of the Rho/Rac family. The aim was to determine its role in endogenous cardioprotection. Methods and Results: Hearts from PKN1 knockout (KO) or wild type (WT) littermate control mice were perfused in Langendorff mode and subjected to global ischemia and reperfusion (I/R). Myocardial infarct size was doubled in PKN1 KO hearts compared to WT hearts. PKN1 was basally phosphorylated on the activation loop Thr778 PDK1 target site which was unchanged during I/R...
October 16, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29025886/th17-cytokines-novel-potential-therapeutic-targets-for-copd-pathogenesis-and-exacerbations
#11
REVIEW
Olivier Le Rouzic, Muriel Pichavant, Emilie Frealle, Antoine Guillon, Mustapha Si-Tahar, Philippe Gosset
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the airways caused mainly by cigarette smoke exposure. COPD progression is marked by exacerbations of the disease, often associated with infections. Recent data show the involvement in COPD pathophysiology of interleukin (IL)-17 and IL-22, two cytokines that are important in the control of lung inflammation and infection. During the initiation and progression of the disease, increased IL-17 secretion causes neutrophil recruitment, leading to chronic inflammation, airways obstruction and emphysema...
October 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29019272/amitriptyline-and-sexual-function-a-systematic-review-updated-for-sexual-health-practice
#12
Louis Wei-Hsi Chen, Melody Yun-Si Chen, Zhi-Ping Lian, Hung-Sheng Lin, Chia-Chang Chien, Hsin-Ling Yin, Yuan-Hsiang Chu, Kuo-Yen Chen
Amitriptyline is an old drug but is still prevalently used as the first-line treatment for a variety of common diseases. Surprisingly, knowledge of sexual risks with amitriptyline comes from only one clinical trial and several case reports from three decades ago. In the current study, a systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) related to amitriptyline and sexual dysfunction (SD) was performed. The frequency, gender-difference, types, disease-specificity and time course of SD, and the relationship between SD and nonsexual adversity were studied...
October 1, 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/28993270/reduced-silent-information-regulator-1-signaling-exacerbates-sepsis-induced-myocardial-injury-and-mitigates-the-protective-effect-of-a-liver-x-receptor-agonist
#13
Dong Han, Xiang Li, Shuang Li, Tao Su, Li Fan, Wen-Si Fan, Hong-Yu Qiao, Jiang-Wei Chen, Miao-Miao Fan, Xiu-Juan Li, Ya-Bin Wang, Sai Ma, Ya Qiu, Zu-Hong Tian, Feng Cao
Myocardial injury and dysfunction are critical manifestations of sepsis. Previous studies have reported that liver X receptor (LXR) activation is protective during sepsis. However, whether LXR activation protects against septic heart injury and its underlying mechanisms remain elusive. This study was designed to determine the role of LXR activation in the septic heart with a focus on SIRT1 (silent information regulator 1) signaling. Male cardiac-specific SIRT1 knockout mice (SIRT1-/-) and their wild-type littermates were subjected to sepsis by cecal ligation and puncture (CLP) in the presence or absence of LXR agonist T0901317...
October 7, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28987946/tetrahydroxy-stilbene-glycoside-tsg-antagonizes-a%C3%AE-induced-hippocampal-neuron-injury-by-suppressing-mitochondrial-dysfunction-via-nrf2-dependent-ho-1-pathway
#14
Chenli Jiao, Feng Gao, Li Ou, Jinhua Yu, Min Li, Peifeng Wei, Feng Miao
Amyloid-beta peptide (Aβ) ranks as a pivotal cause of Alzheimer's disease (AD), a common devastating dementia form in elderly. Recent research corroborated the beneficial roles of tetrahydroxystilbene glucoside (TSG) in alleviating the learning and memory of AD model and aged mice. Unfortunately, the underlying mechanism remains poorly elucidated. Here, treatment with non-toxic TSG dose-dependently antagonized Aβ-induced cytotoxic death in hippocampal neuronal cells by increasing cell viability and decreasing cell apoptosis...
October 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28987617/mitigation-of-postnatal-ethanol-induced-neuroinflammation-ameliorates-trace-fear-memory-deficits-in-juvenile-rats
#15
Molly J Goodfellow, Youn Ju Shin, Derick H Lindquist
Impairments in behavior and cognition are common in individuals diagnosed with fetal alcohol spectrum disorders (FASD). In this study, FASD model rats were intragastrically intubated with ethanol (5g/kg/day; 5E), sham-intubated (SI), or maintained as naïve controls (NC) over postnatal days (PD) 4-9. Ethanol exposure during this human third trimester-equivalent period induces persistent impairments in hippocampus-dependent learning and memory. The ability of ibuprofen (IBU), a non-steroidal anti-inflammatory drug, to diminish ethanol-induced neuroinflammation and rescue deficits in hippocampus-dependent trace fear conditioning (TFC) was investigated in 5E rats...
October 5, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28973588/hba1c-identifies-subjects-with-prediabetes-and-subclinical-left-ventricular-diastolic-dysfunction
#16
Antonino Di Pino, Sarah Mangiafico, Francesca Urbano, Roberto Scicali, Salvatore Scandura, Veronica D'Agate, Salvatore Piro, Corrado Tamburino, Francesco Purrello, Agata Maria Rabuazzo
Context: Prediabetes is associated with subclinical cardiac changes associated with heart failure development. Objective: We investigated diastolic function and its association with markers of glycation and inflammation related to cardiovascular disease in patients with prediabetes. We focused on individuals with prediabetes identified only by glycated hemoglobin A1c [HbA1c; 5.7% to 6.4% and normal fasting glucose (NFG) and normal glucose tolerance (NGT) after an oral glucose tolerance test (OGTT)]...
October 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28971893/the-crosstalk-between-esc-and-m%C3%AF-impairs-cytotoxicity-of-nk-cell-by-secreting-il-10-and-tgf-%C3%AE-in-ems
#17
Hui-Li Yang, Wen-Jie Zhou, Kai-Kai Chang, Jie Mei, Li-Qing Huang, Ming-Yan Wang, Yi Meng, Si-Yao Ha, Da-Jin Li, Ming-Qing Li
The dysfunction of NK cells in women with endometriosis (EMS) contributes to the immune escape of menstrual endometrial fragments refluxed into the peritoneal cavity. The reciprocal communications between endometrial stromal cells (ESCs) and lymphocytes facilitate the development of EMS. However, the mechanism of these communications on cytotoxicity of natural killer (NK) cells in endometriotic milieus is still larger unknown. To imitate the local immune microenvironment, the co-culture systems of ESCs from patients with EMS and monocyte-derived macrophages or of ESCs, macrophages and NK cells were constructed...
October 2, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28967185/itraq-based-proteomics-suggests-ephb6-as-a-potential-regulator-of-the-erk-pathway-in-the-prefrontal-cortex-of-chronic-social-defeat-stress-model-mice
#18
Hua Guo, Zhi-Lin Huang, Wei Wang, Shu-Xiao Zhang, Juan Li, Ke Cheng, Ke Xu, Yong He, Si-Wen Gui, Peng-Fei Li, Hai-Yang Wang, Zhi-Fang Dong, Peng Xie
PURPOSE: Major depressive disorder (MDD) is a worldwide concern and devastating psychiatric disease. The World Health Organization claims that MDD leads to at least 11.9% of the global burden of disease. However, the underlying pathophysiology mechanisms of MDD remain largely unknown. EXPERIMENTAL DESIGN: Herein, we proteomic-based strategy is used to compare the prefrontal cortex (PFC) in chronic social defeat stress (CSDS) model mice with a control group. Based on pooled samples, differential proteins are identified in the PFC proteome using iTRAQ coupled with LC-MS/MS...
October 1, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28949286/altered-intrinsic-functional-brain-architecture-in-female-patients-with-bulimia-nervosa
#19
Li Wang, Qing-Mei Kong, Ke Li, Xue-Ni Li, Ya-Wei Zeng, Chao Chen, Ying Qian, Shi-Jie Feng, Ji-Tao Li, Yun'Ai Su, Christoph U Correll, Philip B Mitchell, Chao-Gan Yan, Da-Rong Zhang, Tian-Mei Si
BACKGROUND: Bulimia nervosa is a severe psychiatric syndrome with uncertain pathogenesis. Neural systems involved in sensorimotor and visual processing, reward and impulsive control may contribute to the binge eating and purging behaviours characterizing bulimia nervosa. However, little is known about the alterations of functional organization of whole brain networks in individuals with this disorder. METHODS: We used resting-state functional MRI and graph theory to characterize functional brain networks of unmedicated women with bulimia nervosa and healthy women...
November 2017: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/28948164/liver-adiposity-and-metabolic-profile-in-individuals-with-chronic-spinal-cord-injury
#20
Kathleen C Rankin, Laura C O'Brien, Liron Segal, M Rehan Khan, Ashraf S Gorgey
PURPOSE: To quantify liver adiposity using magnetic resonance imaging (MRI) and to determine its association with metabolic profile in men with spinal cord injury (SCI). MATERIALS AND METHODS: MRI analysis of liver adiposity by fat signal fraction (FSF) and visceral adipose tissue (VAT) was completed on twenty participants. Intravenous glucose tolerance test was conducted to measure glucose effectiveness (Sg) and insulin sensitivity (Si). Lipid panel, fasting glucose, glycated hemoglobin (HbA1c), and inflammatory cytokines were also analyzed...
2017: BioMed Research International
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