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https://www.readbyqxmd.com/read/28816145/strain-imaging-detects-dose-dependent-segmental-cardiac-dysfunction-in-the-acute-phase-after-breast-irradiation
#1
Queenie Lo, Leia Hee, Vikneswary Batumalai, Christine Allman, Peter MacDonald, Denise Lonergan, Geoff P Delaney, Liza Thomas
PURPOSE: We examined the utility of echocardiographic 2-dimensional speckle tracking strain imaging (SI) for the evaluation of segmental myocardial dysfunction before and after radiation therapy (RT) and the relationship to dose exposure. METHODS AND MATERIALS: We prospectively recruited 40 women with left-sided breast cancer, undergoing only adjuvant RT to the left chest. Comparisons of traditional echocardiographic parameters and SI parameters at baseline and 6 weeks after RT were analyzed...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28723348/central-serotonin-attenuates-lps-induced-systemic-inflammation
#2
Clarissa M D Mota, Caroline Rodrigues-Santos, Rodrigo A R Fernández, Ruither O G Carolino, José Antunes-Rodrigues, Janete A Anselmo-Franci, Luiz G S Branco
Serotonin (5-HT) is a neuromodulator involved in several central-mediated mechanisms, such as endocrine processes, behavior, and sleep. Dysfunction of the serotonergic system is mainly linked to psychiatric disorders, but emerging evidence suggests that immune system activation may also alter brain 5-HT signaling. However, whether central 5-HT modulates systemic inflammation (SI) remains unknown. For this purpose, male Wistar rats (280-350 g, 8-9 weeks) were submitted to the experimental protocols beginning between 9 and 10 AM with the performance of injections...
July 16, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28715448/effect-of-synergistic-interaction-between-abnormal-adiposity-related-metabolism-and-prediabetes-on-microalbuminuria-in-the-general-population
#3
Jong Wook Choi, Il Hwan Oh, Chang Hwa Lee, Joon-Sung Park
Central obesity and related metabolic components are important risks for microalbuminuria. To describe the effects of interactions between central obesity and related metabolic components on microalbuminuria, we conducted a nation-wide, population-based interaction analysis using cardio-metabolic index (CMI) as a candidate indicator of central obesity and related abnormal lipid metabolism. We recruited native Koreans aged 20 years or older with no medical illness. A total of 5398 participants were divided into quintiles according to CMI with sex as a covariate factor...
2017: PloS One
https://www.readbyqxmd.com/read/28713383/the-toxicological-mechanisms-of-environmental-soot-black-carbon-and-carbon-black-focus-on-oxidative-stress-and-inflammatory-pathways
#4
REVIEW
Rituraj Niranjan, Ashwani Kumar Thakur
The environmental soot and carbon blacks (CBs) cause many diseases in humans, but their underlying mechanisms of toxicity are still poorly understood. Both are formed after the incomplete combustion of hydrocarbons but differ in their constituents and percent carbon contents. For the first time, "Sir Percival Pott" described soot as a carcinogen, which was subsequently confirmed by many others. The existing data suggest three main types of diseases due to soot and CB exposures: cancer, respiratory diseases, and cardiovascular dysfunctions...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28710888/chronic-spinal-cord-injury-causes-up-regulation-of-serotonin-5-ht-2a-and-2c-receptors-in-lumbosacral-cord-motoneurons
#5
Nailong Cao, Jianshu Ni, Xiaohu Wang, Hongjian Tu, Baojun Gu, Jiemin Si, Gang Wu, Karl-Erik Andersson
OBJECTIVES: To explore if the mechanism of the voiding dysfunction caused by spinal cord injury in rats can be improved by intravenous administration of the 5-HT2A/2C receptor agonist, DOI, and discuss whether it can be ascribed to serotonin 2A and 2C receptor up-regulation in lumbosacral cord motoneurons. MATERIALS AND METHODS: Female Sprague-Dawley rats were used, which were divided into two groups (Spinal cord injury group VS Normal control group). Under urethane anesthesia, cystometry was performed to examine the variation of urodynamic parameters before and after successive intrathecal administration of various doses of DOI into the lumbosacral cord...
July 15, 2017: BJU International
https://www.readbyqxmd.com/read/28710113/trap1-ameliorates-renal-tubulointerstitial-fibrosis-in-mice-with-unilateral-ureteral-obstruction-by-protecting-renal-tubular-epithelial-cell-mitochondria
#6
Jun-Feng Chen, Qi-Shun Wu, Yu-Xian Xie, Bo-Lin Si, Ping-Ping Yang, Wen-Yan Wang, Qin Hua, Qing He
Mitochondrial dysfunction causes renal tubular epithelial cell injury and promotes cell apoptosis and renal tubulointerstitial fibrosis (TIF) progression. TNF receptor-associated protein 1 (TRAP1) is a molecular chaperone protein that is localized in mitochondria. It plays an important role in cell apoptosis; however, its functional mechanism in TIF remains unclear. In this study, we observed the effects of TRAP1 in renal tubular epithelial cell mitochondria in mice with unilateral ureteral obstruction and its function in cell apoptosis and TIF...
July 14, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28697842/-research-advances-in-immunological-pathogenesis-of-immunoglobulin-a-vasculitis
#7
Ya-Ting Liu, Si-Guang Lu
Immunoglobulin A (IgA) vasculitis is the most common leukocytoclastic small-vessel vasculitis in children and mainly involves the small vessels in the skin, joints, digestive tract, and kidneys. Its pathogenesis is still unclear. Currently, it is believed that environmental factors can cause autoimmune dysfunction and lead to the deposition of IgA-containing immune complexes on the wall of arterioles on the basis of genetic factors. This article reviews the research advances in the role of immune factors in the pathogenesis of IgA vasculitis...
July 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28697478/shedding-lights-on-the-flexible-armed-porphyrins-human-telomeric-g4-dna-interaction-and-cell-photocytotoxicity-research
#8
Xiang-Yu Sun, Ping Zhao, Shu-Fang Jin, Min-Chao Liu, Xia-Hong Wang, Yu-Min Huang, Zhen-Feng Cheng, Si-Qi Yan, Yan-Yu Li, Ya-Qing Chen, Yan-Mei Zhong
DNA polymorphism exerts a fascination on a large scientific community. Without crystallographic structural data, clarification of the binding modes between G-quadruplex (G4) and ligand (complex) is a challenging job. In the present work, three porphyrin compounds with different flexible carbon chains (arms) were designed, synthesized and characterized. Their binding, folding and stabilizing abilities to human telomeric G4 DNA structures were comparatively researched. Positive charges at the end of the flexible carbon chains seem to be favorable for the DNA-porphyrin interactions, which were evidenced by the spectral results and further confirmed by the molecular docking calculations...
July 4, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28655909/plk2-plays-an-essential-role-in-high-d-glucose-induced-apoptosis-ros-generation-and-inflammation-in-podocytes
#9
Hong-Hong Zou, Ping-Ping Yang, Tian-Lun Huang, Xiao-Xu Zheng, Gao-Si Xu
Diabetic kidney disease (DKD) is a serious complication of hyperglycemia. Currently, there is no effective therapeutic intervention for DKD. In this study, we sought to provide a set of gene profile in diabetic kidneys. We identified 338 genes altered in diabetes-induced DKD glomeruli, and PLK2 exhibited the most dramatic change. Gene set enrichment analysis (GSEA) indicated multiple signaling pathways are involved DKD pathogenesis. Here, we investigated whether PLK2 contributes to podocyte dysfunction, a characteristic change in the development of DKD...
June 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28652802/comparison-of-quadrapolar%C3%A2-radiofrequency-lesions-produced-by-standard-versus-modified-technique-an-experimental-model
#10
Ramin Safakish
Lower back pain (LBP) is a global public health issue and is associated with substantial financial costs and loss of quality of life. Over the years, different literature has provided different statistics regarding the causes of the back pain. The following statistic is the closest estimation regarding our patient population. The sacroiliac (SI) joint pain is responsible for LBP in 18%-30% of individuals with LBP. Quadrapolar™ radiofrequency ablation, which involves ablation of the nerves of the SI joint using heat, is a commonly used treatment for SI joint pain...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28612277/3-0%C3%A2-t-magnetic-resonance-myocardial-perfusion-imaging-for-semi-quantitative-evaluation-of-coronary-microvascular-dysfunction-in-hypertrophic-cardiomyopathy
#11
Liang Yin, Hai-Yan Xu, Sui-Sheng Zheng, Ying Zhu, Jiang-Xi Xiao, Wei Zhou, Si-Si Yu, Liang-Geng Gong
This study aimed to assess coronary microvascular dysfunction (CMD) differences in hypertrophic cardiomyopathy (HCM) patients using cardiac magnetic resonance (CMR) first-pass perfusion and late gadolinium enhancement imaging. Forty-seven patients with HCM and twenty-one healthy volunteers underwent CMR at rest. Imaging protocols included short axis cine, first-pass myocardial perfusion, and late gadolinium enhancement (LGE). Left ventricular end-diastolic wall thickness (EDTH), LGE, time to peak (Tpeak), maximal up-slope (Slopemax), and peak signal intensity (SIpeak) were assessed for each myocardial segment...
June 13, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28611589/mitochondrial-effects-of-pgc-1alpha-silencing-in-mpp-treated-human-sh-sy5y-neuroblastoma-cells
#12
Qinyong Ye, Chun Chen, Erwang Si, Yousheng Cai, Juhua Wang, Wanling Huang, Dongzhu Li, Yingqing Wang, Xiaochun Chen
The dopaminergic neuron degeneration and loss that occurs in Parkinson's disease (PD) has been tightly linked to mitochondrial dysfunction. Although the aged-related cause of the mitochondrial defect observed in PD patients remains unclear, nuclear genes are of potential importance to mitochondrial function. Human peroxisome proliferator-activated receptor γ coactivator-1alpha (PGC-1α) is a multi-functional transcription factor that tightly regulates mitochondrial biogenesis and oxidative capacity. The goal of the present study was to explore the potential pathogenic effects of interference by the PGC-1α gene on N-methyl-4-phenylpyridinium ion (MPP(+))-induced SH-SY5Y cells...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28605628/topiramate-associated-sexual-dysfunction-a-systematic-review
#13
REVIEW
Louis Wei-Hsi Chen, Melody Yun-Si Chen, Kuo-Yen Chen, Hung-Sheng Lin, Chia-Chang Chien, Hsin-Ling Yin
INTRODUCTION: Sexual pharmacotoxicity renders patients with epilepsy at a risk for sexual dysfunction (SD). This study is aimed to analyze the relationship between sexual function and topiramate to avoid topiramate-associated SD. METHODS: A systematic review following the PRISMA guidelines was performed to elucidate any SD occurrence in patients receiving topiramate. RESULTS: A total of 17 publications were reviewed. Based on limited polytherapy observational studies, the frequency of self-reported topiramate-associated SD, libido disorder, and orgasmic disorder in patients with polytherapy was 9...
June 9, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28600005/sacroiliac-fusion-another-magic-bullet-destined-for-disrepute
#14
REVIEW
Robert W Bina, R John Hurlbert
Pain related to joint dysfunction can be treated with joint fusion; this is a long-standing principle of musculoskeletal surgery. However, pain arising from the sacroiliac (SI) joint is difficult to diagnose. Several implant devices are available that promote fusion by simply crossing the joint space. Evidence establishing outcomes is misleading because of vague diagnostic criteria, flawed methodology, bias, and limited follow-up. Because of nonstandardized indications and historically inferior reconstruction techniques, SI joint fusion should be considered unproven...
July 2017: Neurosurgery Clinics of North America
https://www.readbyqxmd.com/read/28565798/pcsk9-regulates-apoptosis-in-human-lung-adenocarcinoma-a549-cells-via-endoplasmic-reticulum-stress-and-mitochondrial-signaling-pathways
#15
Xiaohui Xu, Yushang Cui, Lei Cao, Ye Zhang, Yan Yin, Xue Hu
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the subtilisin family of PCs that encodes a neural apoptosis-regulated convertase 1. However, the precise role of PCSK9 in lung cancer cell apoptosis has remained elusive. In the present study, A549 human lung adenocarcinoma cells were transfected with PCSK9 small interfering (si)RNA to investigate the underlying mechanisms of apoptosis. The results indicated that PCSK9 siRNA exhibited anti-tumor activity by inducing apoptosis as determined by a Cell Counting Kit-8 and Hoechst staining analysis...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28560649/group-b-streptococcus-causes-severe-sepsis-in-term-neonates-8-years-experience-of-a-major-chinese-neonatal-unit
#16
Ying Dong, Si-Yuan Jiang, Qi Zhou, Yun Cao
BACKGROUND: In contrast to industrialized countries, the clinical characteristics of neonatal sepsis caused by Group B Streptococcus (GBS) are largely unexplored in China. METHODS: A retrospective case series study was performed at a high-capacity neonatal unit in Shanghai, China from January 2008 to December 2015. Clinical characteristics of neonates with culture-proven GBS sepsis and antibiotic susceptibility of isolated strains were analyzed. RESULTS: Forty-three term neonates were included during the study period...
May 9, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28549710/complication-rates-observed-in-silicone-and-polyurethane-catheters-of-totally-implanted-central-venous-access-devices-implanted-in-the-upper-arm
#17
Jasmin D Busch, Maren Vens, Catherine Mahler, Jochen Herrmann, Gerhard Adam, Harald Ittrich
PURPOSE: To present frequency and types of complications related to silicone (SI) versus polyurethane (PUR) catheters of totally implanted venous access devices (TIVADs) placed in the upper arm. MATERIAL AND METHODS: A cohort of 2,491 consecutive patients with TIVADs implanted between 2006 and 2015 was retrospectively analyzed. Complications were classified according to SIR guidelines. Pearson χ(2) test was used for categorical variables, and Student t test was used for continuous variables...
May 24, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28544341/synthesized-enone-fatty-acids-resembling-metabolites-from-gut-microbiota-suppress-macrophage-mediated-inflammation-in-adipocytes
#18
Ha-Eun Yang, Yongjia Li, Akira Nishimura, Huei-Fen Jheng, Ana Yuliana, Ryuji Kitano-Ohue, Wataru Nomura, Nobuyuki Takahashi, Chu-Sook Kim, Rina Yu, Nahoko Kitamura, Si-Bum Park, Shigenobu Kishino, Jun Ogawa, Teruo Kawada, Tsuyoshi Goto
SCOPE: Recent reports indicate that gut microbiota and their metabolite may regulate inflammatory conditions, including the chronic inflammation of obese adipose tissues, in the host. In this study, we investigated whether specific synthesized fatty acids, identical to the metabolites generated by gut microbiota, act as anti-inflammatory factors in inflammation-induced obesity. METHODS AND RESULTS: We first used lipopolysaccharide-stimulated RAW 264.7 macrophages to examine the anti-inflammatory effect of fatty acids synthesized to resemble representative polyunsaturated fatty acid metabolites from gut microbiota...
May 19, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28544060/predictive-factors-upon-discontinuation-of-renal-replacement-therapy-for-long-term-chronic-dialysis-and-death-in-acute-kidney-injury-patients
#19
Tingting Yang, Si Sun, Liping Lin, Mei Han, Qiang Liu, Xiaoxi Zeng, Yuliang Zhao, Yupei Li, Baihai Su, Songmin Huang, Lichuan Yang
The specific timing for discontinuing renal replacement therapy (RRT) in acute kidney injury (AKI) patients is debatable. The predictive abilities of variables at the time of discontinuation of RRT for the long-term prognoses of patients have not been explored. This study aimed to explore the prognostic factors upon discontinuation of RRT for long-term chronic dialysis and death of patients with acute RRT-requiring AKI, thus improving decision making regarding the discontinuation of RRT and the follow-up of patients thereafter...
May 23, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28539629/early-onset-mild-cognitive-impairment-in-parkinson-s-disease-altered-corticopetal-cholinergic-network
#20
Injoong Kim, Na-Young Shin, Yunjin Bak, Phil Hyu Lee, Seung-Koo Lee, Soo Mee Lim
Degeneration of the substantia innominata (SI) is significantly correlated with cognitive performance in Parkinson's disease (PD). We examined functional and structural patterns of SI degeneration in drug-naïve PD patients according to the duration of parkinsonism before mild cognitive impairment (MCI) diagnosis. Twenty PD patients with a shorter duration (PD-MCI-SD, <1 year), 18 patients with a longer duration (PD-MCI-LD, ≥1 year), and 29 patients with intact cognition (PD-IC) were included. Seed-based resting-state functional connectivity (rsFC) analysis using bilateral SI seed and region-of-interest-based volumetric analysis were performed...
May 24, 2017: Scientific Reports
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