keyword
MENU ▼
Read by QxMD icon Read
search

SI dysfunction

keyword
https://www.readbyqxmd.com/read/28418497/course-of-sodium-iodate-induced-retinal-degeneration-in-albino-and-pigmented-mice
#1
Guy Chowers, Matan Cohen, Devora Marks-Ohana, Shelly Stika, Ayala Eijzenberg, Eyal Banin, Alexey Obolensky
Purpose: To characterize the course of sodium iodate (SI)-induced retinal degeneration in young adult albino and pigmented mice. Methods: Single intraperitoneal (IP) injections of SI (25, 50, and 100 mg/kg) were performed in 7- to 8-week-old BALB/c and C57Bl/6J mice. Retinal function and structure was assessed at baseline, 24 hours, 3 days, 1, 2, 3, and 4 weeks postinjection by optokinetic tracking response, ERG, optical coherence tomography (OCT), and histologic and immunohistochemical techniques...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28412142/early-enriched-physical-environment-reverses-impairments-of-the-hippocampus-but-not-medial-prefrontal-cortex-of-adolescent-socially-isolated-mice
#2
Min Cao, Tinglin Pu, Linmei Wang, Charles Marshall, Hongliang He, Gang Hu, Ming Xiao
Early social isolation (SI) produces a variety of emotional, behavioral and cognitive abnormalities. Conversely, environmental enrichment (EE), a complicated social and physical construct, offers beneficial effects on brain plasticity and development. However, whether or not exclusive physical EE is sufficient to reverse the adverse consequences of adolescent SI remains unclear. Here we reported that 1 month-old solitary mice housed in the EE for 8 weeks corrected spatial cognitive dysfunction, but did not ameliorate social interaction deficits and increased anxiety-like behavior...
April 12, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28402958/thalidomide-combined-with-thanscatheter-artierial-chemoembolzation-for-primary-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#3
REVIEW
De-Dong Cao, Hui-Lin Xu, Liang Liu, Yong-Fa Zheng, Si-Fa Gao, Xi-Ming Xu, Wei Ge
OBJECTIVE: Transcatheter arterial chemoembolization (TACE) and thalidomide have been used for treating primary hepatocellular carcinoma(HCC). This study aims to evaluate the clinical efficacy and safety of thalidomide and TACE in primary HCC. METHODS: Randomized controlled trials(RCTs) about efficacy and safety of thalidomide combined with TACE for primary HCC were identified from the Cochrane Library, Pubmed, Embase, CNKI, and Wan Fang until August, 2016. The retrieved trials were reviewed and the data were extracted by two reviewers, independently...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28396512/pro-inflammatory-cytokine-driven-pi3k-akt-sp1-signaling-and-h2s-production-facilitates-the-pathogenesis-of-severe-acute-pancreatitis
#4
Ying Liu, Ribin Liao, Zhanrong Qiang, Cheng Zhang
Severe acute pancreatitis (SAP) is a disease usually associated with systemic organ dysfunction or pancreatic necrosis. Most patients with SAP suffer from defective intestinal motility in the early phase of the disease. Additionally, SAP-induced inflammation produces hydrogen sulfide (H2S) that impairs the gastrointestinal (GI) system. However, the exact mechanism of H2S in the regulation of SAP is yet to be elucidated. In this paper, we use a rat model of SAP to evaluate the role of H2S on intestinal motility by counting the number of bowel movements and investigating the effect of H2S on inflammation...
April 10, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28376914/suppression-of-laccase-2-severely-impairs-cuticle-tanning-and-pathogen-resistance-during-the-pupal-metamorphosis-of-anopheles-sinensis-diptera-culicidae
#5
Ming-Hui Du, Zheng-Wen Yan, You-Jin Hao, Zhen-Tian Yan, Feng-Ling Si, Bin Chen, Liang Qiao
BACKGROUND: Phenol oxidases (POs) catalyze the oxidation of dopa and dopamine to melanin, which is crucial for cuticle formation and innate immune maintenance in insects. Although, Laccase 2, a member of the PO family, has been reported to be a requirement for melanin-mediated cuticle tanning in the development stages of some insects, whether it participates in cuticle construction and other physiological processes during the metamorphosis of mosquito pupae is unclear. METHODS: The association between the phenotype and the expression profile of Anopheles sinensis Laccase 2 (AsLac2) was assessed from pupation to adult eclosion...
April 4, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28353135/abnormal-brain-structure-implicated-in-patients-with-functional-dyspepsia
#6
Peng Liu, Geliang Wang, Fang Zeng, Yanfei Liu, Yingying Fan, Ying Wei, Wei Qin, Vince D Calhoun
Recent studies suggest dysfunctional brain-gut interactions are involved in the pathophysiology of functional dyspepsia (FD). However, limited studies have investigated brain structural abnormalities in FD patients. This study aimed to identify potential differences in both cortical thickness and subcortical volume in FD patients compared to healthy controls (HCs) and to explore relationships of structural abnormalities with clinical symptoms. Sixty-nine patients and forty-nine HCs underwent 3T structural magnetic resonance imaging scans...
March 28, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28340447/fronto-limbic-disconnection-in-depressed-patients-with-suicidal-ideation-a-resting-state-functional-connectivity-study
#7
Lian Du, Jinkun Zeng, Huan Liu, Dejian Tang, Huaqing Meng, Yongmei Li, Yixiao Fu
BACKGROUND: Suicidal ideation (SI) is highly prevalent and a known symptom of Major Depressive Disorder (MDD), but its underlying biological mechanisms are relatively unknown. Several studies linked suicidal ideation to dysfunctional brain circuits, specifically fronto-limbic connections. The purpose of this work was to investigate fronto-limbic disconnection in MDD patients with or without SI. METHODS: MDD patients with SI (SI, n=28) or without SI (NSI, n=20), identified by the Scale for Suicide Ideation and healthy controls (HCs, n=30) underwent resting-state functional MRI scanning...
February 21, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28322835/role-of-mitochondrial-dysfunction-in-renal-fibrosis-promoted-by-hypochlorite-modified-albumin-in-a-remnant-kidney-model-and-protective-effects-of-antioxidant-peptide-ss-31
#8
Hao Zhao, Yan-Jun Liu, Zong-Rui Liu, Dong-Dong Tang, Xiao-Wen Chen, Yi-Hua Chen, Ru-Ning Zhou, Si-Qi Chen, Hong-Xin Niu
Oxidative stress aggravates renal fibrosis, a pathway involved in almost all forms of chronic kidney disease (CKD). However, the underlying mechanism involved in the pathogenesis of renal oxidative stress has not been completely elucidated. In this study, we explored the role and mechanism of hypochlorite-modified albumin (HOCl-alb) in mediating oxidative stress and fibrotic response in a remnant-kidney rat model. Five-sixths nephrectomy (5/6 NX) was performed on the rats and then the animals were randomly assigned to intravenous treatment with either vehicle alone, or HOCl-rat serum albumin (RSA) in the presence or absence of SS-31 (administered intraperitoneally)...
March 18, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28295626/mechanical-meibomian-gland-squeezing-combined-with-eyelid-scrubs-and-warm-compresses-for-the-treatment-of-meibomian-gland-dysfunction
#9
Hun Lee, Minseo Kim, Si Yoon Park, Eung Kweon Kim, Kyoung Yul Seo, Tae-Im Kim
BACKGROUND: The aim was to investigate the efficacy of mechanical meibomian gland squeezing combined with eyelid scrubs and warm compresses in participants with moderate and severe meibomian gland dysfunction (MGD). METHODS: In this prospective, uncontrolled, open label, intervention study, 32 eyes of 32 participants with moderate and severe MGD were treated with mechanical squeezing of meibomian glands in combination with eyelid scrubs and warm compresses. We evaluated tear film break-up time (TBUT), corneal and conjunctival fluorescein staining scores, biomicroscopic examination of lid margins and meibomian glands, Ocular Surface Disease Index (OSDI) questionnaire and tear film lipid layer thickness determined via an interferometer before initiating treatment and after one month of treatment...
March 12, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28292880/plasma-serpinb1-is-related-to-insulin-sensitivity-but-not-pancreatic-%C3%AE-cell-function-in-non-diabetic-adults
#10
Michael Glicksman, Asha Asthana, Brent S Abel, Mary F Walter, Monica C Skarulis, Ranganath Muniyappa
Pancreatic β-cell dysfunction because of reduced β-cell mass and function is a primary determinant in the progression of diabetes. Increase in β-cell mass and compensatory hyperinsulinaemia is frequently associated with insulin-resistant states. Although the humoral factors mediating this compensatory response are unknown, serpinB1, a protease inhibitor, has recently been proposed to be one such factor. In this study, we examine the relationships between plasma serpinB1, insulin sensitivity, and pancreatic β-cell function in non-diabetic individuals...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28267650/toxic-effects-of-56-fe-ion-radiation-on-the-zebrafish-danio-rerio-embryonic-development
#11
Jing Si, Rong Zhou, Jing'e Song, Lu Gan, Xin Zhou, Cuixia Di, Yang Liu, Aihong Mao, Qiuyue Zhao, Yupei Wang, Hong Zhang
All living organisms and ecosystems are permanently exposed to ionizing radiation. Of all the types of ionizing radiation, heavy ions such as (56)Fe have the potential to cause the most severe biological effects. We therefore examined the effects and potential mechanisms of iron ion irradiation on the induction of developmental toxicity and apoptosis in zebrafish embryos. Zebrafish embryos at 4h post-fertilization (hpf) were divided into five groups: a control group; and four groups irradiated with 0.5, 1, 2, and 4Gy radiation, respectively...
February 28, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28260062/serum-microrna-profiling-and-bioinformatics-analysis-of-patients-with-type-2-diabetes-mellitus-in-a-chinese-population
#12
Ze-Min Yang, Long-Hui Chen, Min Hong, Ying-Yu Chen, Xiao-Rong Yang, Si-Meng Tang, Qian-Fa Yuan, Wei-Wen Chen
Type 2 diabetes mellitus (T2DM) is characterized by islet β-cell dysfunction and insulin resistance, which leads to an inability to maintain blood glucose homeostasis. Circulating microRNAs (miRNAs) have been suggested as novel biomarkers for T2DM prediction or disease progression. However, miRNAs and their roles in the pathogenesis of T2DM remain to be fully elucidated. In the present study, the serum miRNA expression profiles of T2DM patients in Chinese cohorts were examined. Total RNA was extracted from serum samples of 10 patients with T2DM and five healthy controls, and these was used in reverse-transcription‑quantitative polymerase chain reaction analysis with the Exiqon PCR system of 384 serum/plasma miRNAs...
April 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28259990/role-of-gap-junctions-in-the-contractile-response-to-agonists-in-the-mesenteric-resistance-artery-of-rats-with-acute-hypoxia
#13
Huan Liu, Xin-Zhi Li, Min Peng, Wei Ji, Lei Zhao, Li Li, Liang Zhang, Jun-Qiang Si, Ke-Tao Ma
Hypoxic exposure results in the vascular dysfunction and reduction of vasomotor responses and thus disrupts or reduces blood flow in the resistance arteries. Connexin (Cx)-mediated gap junctional intercellular communication (GJIC) serves a critical role in the regulation of vasomotor tone and the synchronized contraction of arteries, however whether the adverse effect of hypoxia on vasomotor responses in vascular smooth muscle layer of resistance arteries is involved in changes in the GJIC and the expression of Cx43 and Cx45 remains to be elucidated...
April 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28258411/ctrp3-attenuates-cardiac-dysfunction-inflammation-oxidative-stress-and-cell-death-in-diabetic-cardiomyopathy-in-rats
#14
Zhen-Guo Ma, Yu-Pei Yuan, Si-Chi Xu, Wen-Ying Wei, Chun-Ru Xu, Xin Zhang, Qing-Qing Wu, Hai-Han Liao, Jian Ni, Qi-Zhu Tang
AIMS/HYPOTHESIS: Oxidative stress, inflammation and cell death are closely involved in the development of diabetic cardiomyopathy (DCM). C1q/tumour necrosis factor-related protein-3 (CTRP3) has anti-inflammatory properties but its role in DCM remains largely unknown. The aims of this study were to determine whether CTRP3 could attenuate DCM and to clarify the underlying mechanisms. METHODS: Streptozotocin (STZ) was injected intraperitoneally to induce diabetes in Sprague-Dawley rats...
March 3, 2017: Diabetologia
https://www.readbyqxmd.com/read/28255260/lumbar-radiofrequency-rhizotomy-in-patients-with-chronic-low-back-pain-increases-the-diagnosis-of-sacroiliac-joint-dysfunction-in-subsequent-follow-up-visits
#15
Varun Kumar Rimmalapudi, Sanjeev Kumar
Chronic back pain is often a result of coexisting pathologies; secondary causes of pain can become more apparent sources of pain once the primary pathology has been addressed. The objective of our study was to determine if there is an increase in diagnosis of Sacroiliac joint pain following a Lumbar Rhizotomy. A list of patients who underwent Lumbar Radiofrequency during a 6-month period in our clinic was generated. Records from subsequent clinic visits were reviewed to determine if a new diagnosis of SI joint pathology was made...
2017: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/28249121/roselle-supplementation-prevents-nicotine-induced-vascular-endothelial-dysfunction-and-remodelling-in-rats
#16
Lislivia Yiang Nee Si, Yusof Kamisah, Anand Ramalingam, Yi Cheng Lim, Siti Balkis Budin, Satirah Zainalabidin
Vascular endothelial dysfunction (VED) plays an important role in initiation of cardiovascular diseases. Roselle which enriched with antioxidants demonstrates high potential in alleviating hypertension. This study was undertaken to investigate effects of roselle supplementation on VED and remodelling in a rodent model with prolonged nicotine administration. Male Sprague-Dawley rats (n=6 per group) were administered with 0.6 mg/kg nicotine for 28 days to induce VED. The rats were given either roselle (100 mg/kg) or normal saline 30 minutes prior to nicotine injection daily...
March 1, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28237480/preventive-and-therapeutic-effect-of-simvastatin-on-secondary-inflammatory-damage-of-rats-with-cerebral-hemorrhage
#17
Hong-Xia Zhou, Ling-Huan Gao, Ling-Li Meng, Yu-Xin Zhang, Zi-Feng Wei, Dao-Wen Si
OBJECTIVE: To investigate the preventive and therapeutic effect and mechanism of simvastatin on secondary inflammatory damage of rats with cerebral hemorrhage. METHODS: Sixty SD rat aged 9-12 weeks were chosen and divided into the control group, model group and simvastatin-treated group randomly with 20 rats in each group. Rats in the model group and simvastatin-treated group were infused with autologous fresh uncoagulated blood to the right brain tissue of the basal ganglia to build the cerebral hemorrhage model, while rats in the control group were treated with the same amount of normal saline...
February 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28237267/trpc5-channel-modulates-endothelial-cells-senescence
#18
Zhengtao Li, Gang Guo, Hongrui Wang, Xiaoqin Si, Guoli Zhou, Yong Xiong, Sujuan Li, Rong Dai, Cui Yang
As a Ca(2+)-permeable cationic channel, canonical transient receptor potential 5 channel (TRPC5) has been known to be involved in various functions of cells. Although TRPC5 is abundantly expressed in vascular endothelium, it remains unknown whether TRPC5 plays a role in regulating endothelial senescence. In the present study, we investigated the involvement of TRPC5 in the senescence of mouse aortic endothelial cells (MAECs). Meanwhile, the regulatory role of TRPC5 in the endothelial dysfunction in aged mice was also studied...
February 22, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28236057/regulation-of-sirtuin-3-mediated-deacetylation-of-cyclophilin-d-attenuated-cognitive-dysfunction-induced-by-sepsis-associated-encephalopathy-in-mice
#19
Fan Sun, Yanna Si, Hongguang Bao, Yajie Xu, XiaoXiao Pan, Lingqing Zeng, Ling Jing
The present study aimed to investigate cognitive dysfunction in the hippocampus induced by sepsis-associated encephalopathy (SAE) via acetylation of cyclophilin D (CypD) and opening of mitochondrial permeability transition pore. It also explored whether activating sirtuin 3 (SIRT3) can mediate deacetylation of CypD and prevent the development of SAE. Male mice were randomly assigned to six groups: sham group, cecal ligation puncture group, CypD siRNA transfection (CypD-si) group, CypD control siRNA transfection (CypD-c) group, SIRT3 overexpression vector pcDNA3...
February 25, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28229590/impacts-of-cross-linkers-on-biological-effects-of-mesoporous-silica-nanoparticles
#20
Yi-Ping Chen, Si-Han Wu, I-Chih Chen, Chien-Tsu Chen
Chemically synthesized cross-linkers play decisive roles in variable cargos attached to nanoparticles (NPs). Previous studies reported that surface properties, such as the size, charge, and surface chemistry, are particularly important determinants influencing the biological fate and actions of NPs and cells. Recent studies also focused on the relationship of serum proteins with the surface properties of NPs (also called the protein corona), which is recognized as a key factor in determining the cytotoxicity and biodistribution...
March 22, 2017: ACS Applied Materials & Interfaces
keyword
keyword
118781
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"