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https://www.readbyqxmd.com/read/29029333/more-than-counting-an-intraindividual-variability-approach-to-categorical-repeated-measures
#1
Rachel E Koffer, Nilam Ram, David M Almeida
Objectives: Age-related differences in daily experiences are often described using summaries of categorical repeated measures, including typologies of stressors, activities, social partners, and coping strategies. This paper illustrates how an intraindividual variability (IIV) framework can be used to extract additional meaning from categorical IIV data. Method: Using 8-occasion categorical data on daily stressors from the National Study of Daily Experiences (N = 1,499, MAge = 46...
September 27, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29029273/the-citizen-science-project-mueckenatlas-helps-monitor-the-distribution-and-spread-of-invasive-mosquito-species-in-germany
#2
Doreen Walther, Helge Kampen
The citizen science project 'Mueckenatlas' (mosquito atlas) was implemented in early 2012 to improve mosquito surveillance in Germany. Citizens are asked to support the spatiotemporal mapping of culicids by submitting mosquito specimens collected in their private surroundings. The Mueckenatlas has developed into an efficient tool for data collection with close to 30,000 mosquitoes submitted by the end of 2015. While the vast majority of submissions included native mosquito species, a small percentage represented invasive species...
September 23, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29029254/retrospective-proteomic-analysis-of-serum-after-akhmeta-virus-infection-new-suspect-case-identification-and-insights-into-poxvirus-humoral-immunity
#3
Michael B Townsend, Nadia F Gallardo-Romero, Ekaterine Khmaladze, Neil M Vora, Giorgi Maghlakelidze, Marika Geleishvili, Darin S Carroll, Ginny L Emerson, Mary G Reynolds, P S Satheshkumar
Serologic cross-reactivity, a hallmark of orthopoxvirus (OPXV) infection, makes species-specific diagnosis of infection difficult. In this study, we used a Variola virus (VARV) proteome microarray to characterize and differentiate antibody responses to non-vaccinia OPXV infections from smallpox vaccination. The profile of two-case patients infected with newly discovered OPXV, Akhmeta virus (AKMV), exhibited antibody responses of greater intensity and broader recognition of viral proteins and includes the B21/22 family glycoproteins not encoded by vaccinia virus (VACV) strains used as vaccines...
October 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29029188/an-analysis-of-the-epidemic-of-kpc-producing-klebsiella-pneumoniae-convergence-of-two-evolutionary-mechanisms-creates-the-perfect-storm
#4
Laura J Rojas, George M Weinstock, Elsa De La Cadena, Lorena Diaz, Rafael Rios, Blake M Hanson, Joseph S Brown, Purva Vats, Daniel S Phillips, Hoan Nguyen, Kristine M Hujer, Adriana Correa, Mark D Adams, Federico Perez, Erica Sodergren, Apurva Narechania, Paul J Planet, Maria V Villegas, Robert A Bonomo, Cesar A Arias
Background: Carbapenem resistance is a critical health care challenge worldwide. Particularly concerning is the widespread dissemination of Klebsiella pneumoniae carbapenemase (KPC). K. pneumoniae harboring blaKPC (KPC-Kpn) is endemic in many areas including United States, where the epidemic was primarily mediated by the clonal dissemination of Kpn ST258. We postulated that the spread of blaKPC in other regions occurs by different and more complex mechanisms. To test this, we investigated the evolution and dynamics of spread of KPC-Kpn in Colombia, where KPC became rapidly endemic after emerging in 2005...
September 27, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29029153/modeling-the-environmental-suitability-for-aedes-stegomyia-aegypti-and-aedes-stegomyia-albopictus-diptera-culicidae-in-the-contiguous-united-states
#5
Tammi L Johnson, Ubydul Haque, Andrew J Monaghan, Lars Eisen, Micah B Hahn, Mary H Hayden, Harry M Savage, Janet McAllister, John-Paul Mutebi, Rebecca J Eisen
The mosquitoes Aedes (Stegomyia) aegypti (L.)(Diptera:Culicidae) and Ae. (Stegomyia) albopictus (Skuse) (Diptera:Culicidae) transmit dengue, chikungunya, and Zika viruses and represent a growing public health threat in parts of the United States where they are established. To complement existing mosquito presence records based on discontinuous, non-systematic surveillance efforts, we developed county-scale environmental suitability maps for both species using maximum entropy modeling to fit climatic variables to county presence records from 1960-2016 in the contiguous United States...
September 21, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29029143/genome-wide-analysis-of-genetic-risk-factors-for-rheumatic-heart-disease-in-aboriginal-australians-provides-support-for-pathogenic-molecular-mimicry
#6
Lesley-Ann Gray, Heather A D'Antoine, Steven Y C Tong, Melita McKinnon, Dawn Bessarab, Ngaire Brown, Bo Reményi, Andrew Steer, Genevieve Syn, Jenefer M Blackwell, Michael Inouye, Jonathan R Carapetis
Background: Rheumatic heart disease (RHD) following Group A Streptococcus (GAS) infections is heritable and prevalent in Indigenous populations. Molecular mimicry between human and GAS proteins triggers pro-inflammatory cardiac valve-reactive T-cells. Methods: Genome-wide genetic analysis was undertaken in 1263 Aboriginal Australians (398 RHD cases; 865 controls). Single nucleotide polymorphisms (SNPs) were genotyped using Illumina HumanCoreExome BeadChips. Direct typing and imputation was used to fine-map the human leukocyte antigen (HLA) region...
September 26, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29029089/geostatistics-and-geographic-information-system-to-analyze-the-spatial-distribution-of-the-diversity-of-anastrepha-species-diptera-tephritidae-the-effect-of-forest-fragments-in-an-urban-area
#7
A G Garcia, M R Araujo, K Uramoto, J M M Walder, R A Zucchi
Fruit flies are among the most damaging insect pests of commercial fruit in Brazil. It is important to understand the landscape elements that may favor these flies. In the present study, spatial data from surveys of species of Anastrepha Schiner (Diptera: Tephritidae) in an urban area with forest fragments were analyzed, using geostatistics and Geographic Information System (GIS) to map the diversity of insects and evaluate how the forest fragments drive the spatial patterns. The results indicated a high diversity of species associated with large fragments, and a trend toward lower diversity in the more urbanized area, as the fragment sizes decreased...
September 23, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/29029012/heterogeneity-of-studies-in-anesthesiology-systematic-reviews-a-meta-epidemiological-review-and-proposal-for-evidence-mapping
#8
B Umberham, R Hedin, B Detweiler, L Kollmorgen, C Hicks, M Vassar
Heterogeneity among the primary studies included in a systematic review (SR) is one of the most challenging considerations for systematic reviewers. Current practices in anaesthesiology SRs have not been evaluated, but traditional methods may not provide sufficient information to evaluate the true nature of these differences. We address these issues by examining the practices for evaluating heterogeneity in anesthesiology reviews. Also, we propose a mapping method for presenting heterogeneous aspects of the primary studies in SRs...
September 27, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29029002/infrared-intraoperative-fluorescence-imaging-using-indocyanine-green-in-thoracic-surgery
#9
Olugbenga T Okusanya, Nicholas R Hess, James D Luketich, Inderpal S Sarkaria
Thoracic surgery faces many unique challenges that require innovative solutions. The increase in utilization of minimally invasive practices, poor overall cancer survival and significant morbidity of key operations remain key obstacles to overcome. Intraoperative fluorescence imaging is a process by which fluorescent dyes and imaging systems are used as adjuncts for surgeons in the operating room. Other surgical subspecialists have shown that intraoperative fluorescence imaging can be applied as a practical adjunct to their practices...
September 27, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29028925/influence-of-bayesian-optimization-on-the-performance-of-propofol-target-controlled-infusion
#10
J P van den Berg, D J Eleveld, T De Smet, A V M van den Heerik, K van Amsterdam, B J Lichtenbelt, T W L Scheeren, A R Absalom, M M R F Struys
Background: Target controlled infusion (TCI) systems use population-based pharmacokinetic (PK) models that do not take into account inter-individual residual variation. This study compares the bias and inaccuracy of a population-based vs a personalized TCI propofol titration using Bayesian adaptation. Haemodynamic and hypnotic stability, and the prediction probability of alternative PK models, was studied. Methods: A double-blinded, prospective randomized controlled trial of 120 subjects undergoing cardiac surgery was conducted...
October 3, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29028886/analysis-of-protein-targets-in-pathogen-host-interaction-in-infectious-diseases-a-case-study-on-plasmodium-falciparum-and-homo-sapiens-interaction-network
#11
Sovan Saha, Kaustav Sengupta, Piyali Chatterjee, Subhadip Basu, Mita Nasipuri
Infection and disease progression is the outcome of protein interactions between pathogen and host. Pathogen, the role player of Infection, is becoming a severe threat to life as because of its adaptability toward drugs and evolutionary dynamism in nature. Identifying protein targets by analyzing protein interactions between host and pathogen is the key point. Proteins with higher degree and possessing some topologically significant graph theoretical measures are found to be drug targets. On the other hand, exceptional nodes may be involved in infection mechanism because of some pathway process and biologically unknown factors...
September 23, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/29028882/enzymatic-methods-for-genome-wide-profiling-of-protein-binding-sites
#12
Robert A Policastro, Gabriel E Zentner
Genome-wide mapping of protein-DNA interactions is a staple approach in many areas of modern molecular biology. Genome-wide profiles of protein-binding sites are most commonly generated by chromatin immunoprecipitation and high-throughput sequencing (ChIP-seq). Although ChIP-seq has played a central role in studying genome-wide protein binding, recent work has highlighted systematic biases in the technique that warrant technical and interpretive caution and underscore the need for orthogonal techniques to both confirm the results of ChIP-seq studies and uncover new insights not accessible to ChIP...
October 6, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/29028635/are-we-on-the-same-page-shared-mental-models-to-support-clinical-teamwork-among-health-professions-learners-a-scoping-review
#13
Leslie Carstensen Floren, DorAnne Donesky, Evans Whitaker, David M Irby, Olle Ten Cate, Bridget C O'Brien
PURPOSE: To conduct a scoping review to explore the construct of shared mental models (SMMs) in the context of clinical teamwork among health professions learners. METHOD: The authors searched the PubMed, ERIC, CINAHL, Scopus, Web of Science, PsychINFO, and EMBASE databases for English-language articles published between 2000 and 2016. Eligible articles mentioned SMMs in relation to clinical teamwork and included health professions learners. Two reviewers screened studies for eligibility and extracted data to determine the depth and breadth of the literature on SMMs...
October 12, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29028612/where-do-spontaneous-first-impressions-of-faces-come-from
#14
Harriet Over, Richard Cook
Humans spontaneously attribute a wide range of traits to strangers based solely on their facial features. These first impressions are known to exert striking effects on our choices and behaviours. In this paper, we provide a theoretical account of the origins of these spontaneous trait inferences. We describe a novel framework ('Trait Inference Mapping') in which trait inferences are products of mappings between locations in 'face space' and 'trait space'. These mappings are acquired during ontogeny and allow excitation of face representations to propagate automatically to associated trait representations...
October 10, 2017: Cognition
https://www.readbyqxmd.com/read/29028566/concept-mapping-to-promote-meaningful-learning-help-relate-theory-to-practice-and-improve-learning-self-efficacy-in-asian-mental-health-nursing-students-a-mixed-methods-pilot-study
#15
Daniel T Bressington, Wai-Kit Wong, Kar Kei Claire Lam, Wai Tong Chien
OBJECTIVES: Student nurses are provided with a great deal of knowledge within university, but they can find it difficult to relate theory to nursing practice. This study aimed to test the appropriateness and feasibility of assessing Novak's concept mapping as an educational strategy to strengthen the theory-practice link, encourage meaningful learning and enhance learning self-efficacy in nursing students. DESIGN: This pilot study utilised a mixed-methods quasi-experimental design...
October 5, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29028510/comparison-of-virtual-monochromatic-series-iodine-overlay-maps-and-single-energy-ct-equivalent-images-in-head-and-neck-cancer-conspicuity
#16
Michael Kraft, Mohannad Ibrahim, Matthew Spector, Reza Forghani, Ashok Srinivasan
OBJECTIVE: To compare lesion conspicuity amongst DECT monochromatic series (40, 45, 50keV), and single-energy CT (SECT) equivalent images in head and neck squamous cell carcinomas (HNSCC). METHODS: Two readers compared DECT images to 70keV SECT equivalent series in 39 patients with HNSCC on lesion margin, enhancement, and overall conspicuity. RESULTS: The 45keV and 50keV images were significantly better (p-values ≤0.001) than the SECT equivalent in lesion enhancement, margins, and overall conspicuity for both readers...
September 29, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29028411/expanding-the-map-of-protein-rna-interaction-sites-via-cell-fusion-followed-by-par-clip
#17
Florian Hinze, Philipp Drewe-Boß, Miha Milek, Uwe Ohler, Markus Landthaler, Michael Gotthardt
PAR-CLIP (photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation) facilitates the identification and mapping of protein/RNA interactions. So far, it has been limited to select cell-lines as it requires efficient 4SU uptake. To increase transcriptome complexity and thus identify additional RNA-protein interaction sites we fused HEK 293 T-Rex cells (HEK293-Y) that express the RNA binding protein YBX1 with PC12 cells expressing eGFP (PC12-eGFP). The resulting hybrids enable PAR-CLIP on a neuronally expanded transcriptome (Fusion-CLIP) and serve as a proof of principle...
October 13, 2017: RNA Biology
https://www.readbyqxmd.com/read/29028369/toll-like-receptors-significance-ligands-signaling-pathways-and-functions-in-mammals
#18
Mallenahally Kusha Vidya, V Girish Kumar, Veerasamy Sejian, Madiajagan Bagath, Govindan Krishnan, Raghavendra Bhatta
This review attempts to cover the implication of the toll-like receptors (TLRs) in controlling immune functions with emphasis on their significance, function, regulation and expression patterns. The tripartite TLRs are type I integral transmembrane receptors that are involved in recognition and conveying of pathogens to the immune system. These paralogs are located on cell surfaces or within endosomes. The TLRs are found to be functionally involved in the recognition of self and non-self-antigens, maturation of DCs and initiation of antigen-specific adaptive immune responses as they bridge the innate and adaptive immunity...
October 13, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/29028328/using-covalent-labeling-and-mass-spectrometry-to-study-protein-binding-sites-of-amyloid-inhibiting-molecules
#19
Tianying Liu, Tyler M Marcinko, Patrick A Kiefer, Richard W Vachet
Amyloid aggregates are associated with several debilitating diseases, and there are numerous efforts to develop small molecule treatments against these diseases. One challenge associated with these efforts is determining protein binding site information for potential therapeutics because amyloid-forming proteins rapidly form oligomers and aggregates, making traditional protein structural analysis techniques challenging. Using β-2-microglobulin (β2m) as a model amyloid-forming protein along with two recently identified small molecule amyloid inhibitors (i...
October 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29028313/anomalous-corrosion-of-bulk-transition-metal-diselenides-leading-to-stable-monolayers
#20
Yu-Ting Huang, Akhil Dodda, Daniel S Schulman, Amritanand Sebastian, Fu Zhang, Drew Buzzell, Mauricio Terrones, Shien-Ping Feng, Saptarshi Das
In this paper we provide insight into an anomalous corrosion process, referred to as electro-ablation (EA), which converts multi-layer flakes of transition metal diselenides like MoSe2 into their corresponding monolayers when micromechanically exfoliated on a conductive electrode and subsequently subjected to a high anodic potential inside a conventional electrochemical cell. Photoluminescence intensity map and scanning transmission electron microscopy (STEM) images confirmed the single crystalline nature and 2H-hexagonal lattice structure of the remnant monolayer MoSe2 flakes, indicating the superior corrosion stability of the monolayers compared to the bulk counterpart...
October 13, 2017: ACS Applied Materials & Interfaces
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