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https://www.readbyqxmd.com/read/28719910/correlating-the-genetic-and-physical-map-of-barley-chromosome-3h-revealed-limitations-of-the-fish-based-mapping-of-nearby-single-copy-probes-caused-by-the-dynamic-structure-of-metaphase-chromosomes
#1
Fernanda O Bustamante, Lala Aliyeva-Schnorr, Jörg Fuchs, Sebastian Beier, Andreas Houben
Genetic maps are based on the recombination frequency of molecular markers which often show different positions in comparison to the corresponding physical maps. To decipher the position and order of DNA sequences genetically mapped to terminal and interstitial regions of barley (Hordeum vulgare) chromosome 3H, fluorescence in situ hybridization (FISH) on mitotic metaphase chromosomes was performed with 16 genomic single-copy probes derived from fingerprinted BAC contigs. Long genetic distances at subterminal regions translated into short physical distances, confirming that recombination events occur more often at distal regions of chromosome 3H...
July 19, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/28719906/a-common-ancestral-asn242ser-mutation-in-tmem67-identified-in-multiple-iranian-families-with-joubert-syndrome
#2
MohammadReza Dehghani, Majid Mojarad, Ehsan Ghayoor Karimiani, Mohammad Yahya Vahidi Mehrjardi, Afsaneh Sahebalzamani, Farah Ashrafzadeh, Mehran Beiraghi Toosi, Atiyeh Eslahi, Najmeh Ahangari, Seyed Mojtaba Yassini, Afsaneh Hassanbeigi, Azam Rasti, Seyed Mehdi Kalantar, Reza Maroofian
BACKGROUND: Joubert syndrome (JS) is a clinically and genetically heterogeneous group of rare neurodevelopmental disorder characterised by peculiar midbrain-hindbrain malformation, known as the "molar tooth" sign. JS can manifest a broad range of signs and symptoms. The most common features of JS are hypotonia, ataxia, developmental delay/intellectual disability, abnormal eye movements, and neonatal breathing abnormalities. To date, 29 genes have been shown to cause JS. METHODS: We employed whole-genome single nucleotide polymorphism genotyping in a group of Iranian families with JS and Sanger sequencing of a known mutation associated with JS located in a single homozygous regions shared by affected members of the families...
July 19, 2017: Public Health Genomics
https://www.readbyqxmd.com/read/28719903/thinning-of-inner-retinal-layers-after-vitrectomy-with-silicone-oil-versus-gas-endotamponade-in-eyes-with-macula-off-retinal-detachment
#3
Konstantine Purtskhvanidze, Jost Hillenkamp, Jan Tode, Olaf Junge, Jürgen Hedderich, Johann Roider, Felix Treumer
PURPOSE: To evaluate retinal layer thickness with optical coherence tomography (OCT) in eyes with macula-off retinal detachment after silicone oil (SiO) or gas endotamponade. PROCEDURES: Cross-sectional study of 40 eyes with macula-off rhegmatogenous retinal detachment that underwent vitrectomy. 20 eyes received SiO tamponade and 20 matched eyes received gas. 33 healthy fellow eyes served as controls. Macular spectral domain OCT was performed with automated layer detection in the 5 inner subfields of the Early Treatment Diabetic Retinopathy Study (ETDRS) map...
July 19, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28719847/high-photocatalytic-activity-of-hierarchical-sio2-c-doped-tio2-hollow-spheres-in-uv-and-visible-light-towards-degradation-of-rhodamine-b
#4
Ying Zhang, Juanrong Chen, Li Hua, Songjun Li, Xuanxuan Zhang, Weichen Sheng, Shunsheng Cao
Ongoing research activities are targeted to explore high photocatalytic activity of TiO2-based photocatalysts for the degradation of environmental contaminants under UV and visible light irradiation. In this work, we devise a facile, cost-effective technique to in situ synthesize hierarchical SiO2@C-doped TiO2 (SCT) hollow spheres for the first time. This strategy mainly contains the preparation of monodisperse cationic polystyrene spheres (CPS), sequential deposition of inner SiO2, the preparation of the sandwich-like CPS@SiO2@CPS particles, and formation of outer TiO2...
July 10, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28719844/phosphate-functionalized-4-4-armchair-cnts-as-novel-drug-delivery-systems-for-alendronate-and-etidronate-anti-osteoporosis-drugs
#5
Zahra Nikfar, Zahra Shariatinia
The ability of (4,4)-armchair CNT and its three phosphate functionalized forms (CNT-nH2PO4, n=1-3) were evaluated as novel drug delivery systems (DDSs) for the two commercially well-known anti-osteoporosis drugs namely alendronate (AL) and etidronate (ET). For this purpose, the DFT calculations were accomplished at both B3LYP and B3PW91 levels using 6-31g(d) basis set. The binding energy was increased by increasing number of H2PO4 moieties attached on the CNT with the most negative binding energy was measured for the carrier containing three phosphate groups...
July 8, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28719638/combination-of-twelve-alleles-at-six-quantitative-trait-loci-determines-grain-weight-in-rice
#6
Yuxiang Zeng, Junsheng Shi, Zhijuan Ji, Zhihua Wen, Yan Liang, Changdeng Yang
Grain weight, which is controlled by quantitative trait loci (QTLs), is one of the most important determinants of rice yield. Although many QTLs for grain weight have been identified, little is known about how different alleles in different QTLs coordinate to determine grain weight. In the present study, six grain-weight-QTLs were detected in seven mapping populations (two F2, one F3, and four recombinant inbred lines) developed by crossing 'Lemont', a United States japonica variety, with 'Yangdao 4', a Chinese indica variety...
2017: PloS One
https://www.readbyqxmd.com/read/28719573/crystalline-metamaterials-for-topological-properties-at-subwavelength-scales
#7
Simon Yves, Romain Fleury, Thomas Berthelot, Mathias Fink, Fabrice Lemoult, Geoffroy Lerosey
The exciting discovery of topological condensed matter systems has lately triggered a search for their photonic analogues, motivated by the possibility of robust backscattering-immune light transport. However, topological photonic phases have so far only been observed in photonic crystals and waveguide arrays, which are inherently physically wavelength scaled, hindering their application in compact subwavelength systems. In this letter, we tackle this problem by patterning the deep subwavelength resonant elements of metamaterials onto specific lattices, and create crystalline metamaterials that can develop complex nonlocal properties due to multiple scattering, despite their very subwavelength spatial scale that usually implies to disregard their structure...
July 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28719508/is-the-organisation-of-the-primary-motor-cortex-in-low-back-pain-related-to-pain-movement-and-or-sensation
#8
Edith Elgueta-Cancino, Siobhan Schabrun, Paul Hodges
Primary motor cortex (M1) organisation differs between individuals with and without chronic low back pain (CLBP), in parallel with motor and sensory impairments. This study investigated whether movement behaviour and tactile/pain sensation are related to M1 organisation in CLBP. Transcranial magnetic stimulation (TMS) was used to map the M1 representation of the erector spinae and multifidus muscles in 20 participants with and without CLBP. Cortical organisation was quantified by: map volume; center of gravity (CoG); number of peaks; and primary and secondary peak location...
July 17, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28719243/genotyping-by-sequencing-based-genetic-analysis-of-african-rice-cultivars-and-association-mapping-of-blast-resistance-genes-against-magnaporthe-oryzae-populations-in-africa
#9
Emmanuel M Mgonja, Chan Ho Park, Houxiang Kang, Elias G Balimponya, Stephen Opiyo, Maria Bellizzi, Samuel K Mutiga, Felix Rotich, Veena Devi Ganeshan, Robert Mabagala, Clay Sneller, Jim Correll, Bo Zhou, Nicholas J Talbot, Thomas K Mitchell, Guo-Liang Wang
Understanding the genetic diversity of rice germplasm is important for the sustainable use of genetic materials in rice breeding and production. Africa is rich in rice genetic resources that can be utilized to boost rice productivity on the continent. A major constraint to rice production in Africa is rice blast, caused by the hemibiotrophic fungal pathogen Magnaporthe oryzae. In this report, we present the results of a genotyping-by-sequencing (GBS)-based diversity analysis of 190 African rice cultivars and an association mapping of blast resistance (R) genes and quantitative trait loci (QTLs)...
July 18, 2017: Phytopathology
https://www.readbyqxmd.com/read/28719238/mining-databases-for-protein-aggregation-a-review
#10
Paraskevi L Tsiolaki, Katerina C Nastou, Stavros J Hamodrakas, Vassiliki A Iconomidou
Protein aggregation is an active area of research in recent decades, since it is the most common and troubling indication of protein instability. Understanding the mechanisms governing protein aggregation and amyloidogenesis is a key component to the aetiology and pathogenesis of many devastating disorders, including Alzheimer's disease or type 2 diabetes. Protein aggregation data are currently found "scattered" in an increasing number of repositories, since advances in computational biology greatly influence this field of research...
July 18, 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28719236/applying-an-artificial-neural-network-model-for-developing-a-severity-score-for-patients-with-hereditary-amyloid-polyneuropathy
#11
Shenia Novis, Felipe Machado, Victor B Costa, Debora Foguel, Marcia W Cruz, José Manoel de Seixas
Hereditary (familial) amyloid polyneuropathy (FAP) is a systemic disease that includes a sensorimotor polyneuropathy related to transthyretin (TTR) mutations. So far, a scale designed to classify the severity of this disease has not yet been validated. This work proposes the implementation of an artificial neural network (ANN) in order to develop a severity scale for monitoring the disease progression in FAP patients. In order to achieve this goal, relevant symptoms and laboratory findings were collected from 98 Brazilian patients included in THAOS - the Transthyretin Amyloidosis Outcomes Survey...
July 18, 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28719002/eyeslam-real-time-simultaneous-localization-and-mapping-of-retinal-vessels-during-intraocular-microsurgery
#12
Daniel Braun, Sungwook Yang, Joseph N Martel, Cameron N Riviere, Brian C Becker
BACKGROUND: Fast and accurate mapping and localization of the retinal vasculature is critical to increasing the effectiveness and clinical utility of robot-assisted intraocular microsurgery such as laser photocoagulation and retinal vessel cannulation. METHODS: The proposed EyeSLAM algorithm delivers 30 Hz real-time simultaneous localization and mapping of the human retina and vasculature during intraocular surgery, combining fast vessel detection with 2D scan-matching techniques to build and localize a probabilistic map of the vasculature...
July 18, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28718993/role-of-fdg-pet-mri-fdg-pet-ct-and-dynamic-susceptibility-contrast-perfusion-mri-in-differentiating-radiation-necrosis-from-tumor-recurrence-in-glioblastomas
#13
Mojgan Hojjati, Chaitra Badve, Vasant Garg, Curtis Tatsuoka, Lisa Rogers, Andrew Sloan, Peter Faulhaber, Pablo R Ros, Leo J Wolansky
BACKGROUND AND PURPOSE: To compare the utility of quantitative PET/MRI, dynamic susceptibility contrast (DSC) perfusion MRI (pMRI), and PET/CT in differentiating radiation necrosis (RN) from tumor recurrence (TR) in patients with treated glioblastoma multiforme (GBM). METHODS: The study included 24 patients with GBM treated with surgery, radiotherapy, and temozolomide who presented with progression on imaging follow-up. All patients underwent PET/MRI and pMRI during a single examination...
July 18, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28718954/power-profiles-in-multifocal-contact-lenses-with-variable-multifocal-zone
#14
Daniel Monsálvez-Romín, Alberto Domínguez-Vicent, Santiago García-Lázaro, José J Esteve-Taboada, Alejandro Cerviño
BACKGROUND: The power profile of multifocal contact lenses has been demonstrated to report important information that could be used during the fitting process. The aim of this work is to describe the power profile of a recent set of gas permeable multifocal contact lenses as a function of the pupil radius. METHODS: The measured multifocal contact lenses have a centre-distance design, and are available with five distance-vision diameters (XS, S, M, L and XL) and two different additions: Type A (up to +2...
July 18, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28718888/assessing-lung-function-using-contrast-enhanced-dual-energy-computed-tomography-for-potential-applications-in-radiation-therapy
#15
Andréanne Lapointe, Houda Bahig, Danis Blais, Hugo Bouchard, Édith Filion, Jean-François Carrier, Stéphane Bedwani
PURPOSE: There is an increasing interest in the evaluation of lung function from physiological images in radiation therapy treatment planning to reduce the extent of post-radiation toxicities. The purpose of this work is to retrieve reliable functional information from contrast-enhanced dualenergy computed tomography (DECT) for new applications in radiation therapy. The functional information obtained by DECT is also compared with other methods using single energy CT (SECT) and single-photon emission computed tomography (SPECT) with CT...
July 18, 2017: Medical Physics
https://www.readbyqxmd.com/read/28718849/an-efficient-method-to-transcription-factor-binding-sites-imputation-via-simultaneous-completion-of-multiple-matrices-with-positional-consistency
#16
Wei-Li Guo, De-Shuang Huang
Transcription factors (TFs) are DNA-binding proteins that have a central role in regulating gene expression. Identification of DNA-binding sites of TFs is a key task in understanding transcriptional regulation, cellular processes and disease. Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) enables genome-wide identification of in vivo TF binding sites. However, it is still difficult to map every TF in every cell line owing to cost and biological material availability, which poses an enormous obstacle for integrated analysis of gene regulation...
July 18, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28718837/interactivity-and-trust-as-antecedents-of-e-training-use-intention-in-nigeria-a-structural-equation-modelling-approach
#17
A U Alkali, Nur Naha Abu Mansor
BACKGROUND: The last few decades saw an intense development in information technology (IT) and it has affected the ways organisations achieve their goals. Training, in every organisation is an ongoing process that aims to update employees' knowledge and skills towards goals attainment. Through adequate deployment of IT, organisations can effectively meet their training needs. However, for successful IT integration in training, the employees who will use the system should be positively disposed towards it...
July 18, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28718721/mapping-the-developmental-trajectory-of-bipolar-disorder-importance-of-prerequisite-groundwork
#18
Anne Duffy, Gin S Malhi
No abstract text is available yet for this article.
August 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28718633/tio2-nanorods-decorated-with-pd-nanoparticles-for-enhanced-liquefied-petroleum-gas-sensing-performance
#19
Dattatray S Dhawale, Tanaji Pralhad Gujar, Chandrakant D Lokhande
The development of highly sensitive and selective semiconductor based metal oxide sensor devices to detect toxic, ex-plosive, flammable and pollutant gases is still a challenging research topic. In the present work, we systematically en-hanced the liquefied petroleum gas (LPG) sensing performance of chemical bath deposited (CBD) TiO2 nanorods by decorating Pd nanoparticle catalyst. Surface morphology with elemental mapping, crystal structure, composition and oxidation states and surface area measurements of pristine TiO2 and Pd:TiO2 nanorods were examined by high resolu-tion transmission electron microscopy (HR-TEM) equipped with an EDS detector, X-ray diffraction (XRD), X-ray pho-toelectron spectroscopy (XPS) and nitrogen adsorption-desorption characterization techniques...
July 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28718624/covalent-enzyme-inhibition-through-fluorosulfate-modification-of-a-non-catalytic-serine-residue
#20
Olugbeminiyi O Fadeyi, Lise R Hoth, Chulho Choi, Xidong Feng, Ariamala Gopalsamy, Erik C Hett, Robert E Kyne, Ralph P Robinson, Lyn H Jones
Irreversible enzyme inhibitors often utilize the reaction of a protein cysteine residue with an appropriately positioned electrophile (an acrylamide for example) in the ligand template. Cysteine residues are not always available for site-specific protein labeling and therefore new approaches are needed to expand the toolkit of appropriate electrophiles that target alternative amino acids. We have previously described the rational targeting of tyrosine residues in the active site of a protein (the mRNA decapping scavenger enzyme, DcpS) using inhibitors armed with sulfonyl fluoride electrophiles that additionally enabled the subsequent development of clickable probe technology to measure drug-target occupancy in live cells...
July 18, 2017: ACS Chemical Biology
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