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https://www.readbyqxmd.com/read/28551425/effects-of-coating-materials-and-processing-conditions-on-flow-enhancement-of-cohesive-acetaminophen-powders-by-high-shear-processing-with-pharmaceutical-lubricants
#1
Guoguang Wei, Sharad Mangal, John Denman, Thomas Gengenbach, Kevin Lee Bonar, Rubayat Islam Khan, Li Qu, Tonglei Li, Qi Tony Zhou
This study has investigated the surface coating efficiency and powder flow improvement of a model cohesive acetaminophen powder by high shear processing with pharmaceutical lubricants via two common equipment, conical comil and high shear mixer. Effects of formulation and processing parameters on powder flow and surface coating coverage were evaluated. Both Carr's index and shear cell data indicated that processing with the lubricants using comil or high shear mixer substantially improved the flow of the cohesive acetaminophen powder...
May 24, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28551388/anaplastic-lymphoma-kinase-protein-positive-diffuse-large-b-cell-lymphoma-a-developing-world-experience
#2
Huzaifah Salat, Nasir Ud Din, Tariq Moatter, Naila Kayani, Arsalan Ahmed
Anaplastic lymphoma kinase (ALK) positive diffuse large B-cell lymphoma (ALK+DLBCL) is a rare, distinct and aggressive subtype of non-Hodgkin's lymphoma (NHL). These tumors are considered to be derived from post-germinal center B cells but peculiarly their distinction is based on the fact that they are ALK-positive neoplastic B cells but lack expression of B cell markers (CD19,CD20, CD79a), T cell markers (CD3, CD5) and CD30. Its broad differential diagnosis and similarities to plasmablastic lymphoma, immunoblastic DLBCL, Anaplastic large-cell lymphoma (ALCL) of T-null cell lineage, and poorly differentiated/anaplastic carcinoma pose a grave challenge to physicians with conventional costly treatment for DLBCL failing to yield any clinical or prognostic significance in ALK+DLBCL...
March 6, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28550980/synthesis-and-spectroscopic-studies-of-ru-ii-complexes-of-steroidal-thiosemicarbazones-by-multi-step-reaction-as-anti-bacterial-agents
#3
Salman A Khan, Abdullah M Asiri
Ru(II) steroidal metal complexes were synthesized by the reaction of dichlorodicarbonyl ruthenium (II) [Ru(CO)2Cl2]n with Steroidal thiosemicarbazones. Coordination via the thionic sulfur and the azomethine nitrogen atom of the thiosemicarbazone to the Ru(II) metal. Steroidal thiosemicarbazone derivatives were obtained by the thiosemicarbazide with steroidal ketones. Structures of the steroidal thiosemicarbazone and their metal complexes were confirmed by the FT-IR, (1)H-NMR, (13)C-NMR, Fab-Mass spectroscopy and elemental analysis...
May 24, 2017: Steroids
https://www.readbyqxmd.com/read/28550635/growth-corruption-health-triaca-and-environmental-degradation-empirical-evidence-from-indonesia-malaysia-and-thailand
#4
Muhammad Azam, Abdul Qayyum Khan
This study examines the impact of economic growth, corruption, health, and poverty on environmental degradation for three countries from ASEAN, namely Indonesia, Malaysia, and Thailand using annual data over the period of 1994-2014. The relationship between environmental degradation (pollution) by carbon dioxide (CO2) emissions and economic growth is examined along with some other variables, namely health expenditure, poverty, agriculture value added growth, industrial value added growth, and corruption. The ordinary least squares (OLS) method is applied as an analytical technique for parameter estimation...
May 27, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28550601/potential-toxicity-of-trace-elements-and-nanomaterials-to-chinese-cabbage-in-arsenic-and-lead-contaminated-soil-amended-with-biochars
#5
Yasser Mahmoud Awad, Meththika Vithanage, Nabeel Khan Niazi, Muhammad Rizwan, Jörg Rinklebe, Jae E Yang, Yong Sik Ok, Sang Soo Lee
To our knowledge, this is the first report on exploring the interactive effects of various biochars (BCs) and nanomaterials (NMs) on plant growth and bioavailability of trace elements in soil. This study evaluated the bioavailability and toxicity of arsenic (As), lead (Pb), and NMs to cabbage plants. The BCs were produced from rice husk (RB), sewage sludge, and bamboo wood (WB). The BCs at 2.5 and 5% (w w(-1)), NMs for removing As (NMs-As) and heavy metals (NMs-HM) at 3000 mg kg(-1), and multi-walled carbon nanotubes (CNT) at 1000 mg kg(-1) were applied in bioassay and incubation experiments (40 days), along with the unamended soil as the control...
May 26, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28550398/association-of-tumor-size-and-focality-with-recurrence-persistence-in-papillary-thyroid-cancer-patients-treated-with-total-thyroidectomy-along-with-radioactive-iodine-ablation-and-tsh-suppression
#6
Misbah Khan, Aamir Ali Syed, Amina Iqbal Khan, Syed Raza Hussain, Namra Urooj
Locoregional recurrence is common in papillary thyroid cancer PTC and an optimal surgical treatment with respect to the multifocal nature of the disease stays controversial. It is a retrospective analytical study design. 209 diagnosed PTCs managed at our institute were grouped into macro-PTC with a size of dominant focus >1 cm (unifocal n = 106 and multifocal n = 64) and micro-PTMC if size of all foci was <1 cm; (unifocal n = 16 and multifocal PTMC n = 23). The primary endpoint is recurrence and tumor free survival in each of the four groups...
May 26, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28550289/heat-transfer-enhancement-in-free-convection-flow-of-cnts-maxwell-nanofluids-with-four-different-types-of-molecular-liquids
#7
Sidra Aman, Ilyas Khan, Zulkhibri Ismail, Mohd Zuki Salleh, Qasem M Al-Mdallal
This article investigates heat transfer enhancement in free convection flow of Maxwell nanofluids with carbon nanotubes (CNTs) over a vertically static plate with constant wall temperature. Two kinds of CNTs i.e. single walls carbon nanotubes (SWCNTs) and multiple walls carbon nanotubes (MWCNTs) are suspended in four different types of base liquids (Kerosene oil, Engine oil, water and ethylene glycol). Kerosene oil-based nanofluids are given a special consideration due to their higher thermal conductivities, unique properties and applications...
May 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28550195/dipeptidyl-peptidase-4-inhibition-stimulates-distal-tubular-natriuresis-and-increases-in-circulating-sdf-1%C3%AE-1-67-in-patients-with-type-2-diabetes
#8
Julie A Lovshin, Harindra Rajasekeran, Yulyia Lytvyn, Leif E Lovblom, Shajiha Khan, Robel Alemu, Amy Locke, Vesta Lai, Huaibing He, Lucinda Hittle, Weixun Wang, Daniel J Drucker, David Z I Cherney
OBJECTIVE: Antihyperglycemic agents, such as empagliflozin, stimulate proximal tubular natriuresis and improve cardiovascular and renal outcomes in patients with type 2 diabetes. Because dipeptidyl peptidase 4 (DPP-4) inhibitors are used in combination with sodium-glucose cotransporter 2 (SGLT-2) inhibitors, we examined whether and how sitagliptin modulates fractional sodium excretion and renal and systemic hemodynamic function. RESEARCH DESIGN AND METHODS: We studied 32 patients with type 2 diabetes in a prospective, double-blind, randomized, placebo-controlled trial...
May 26, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28550145/paediatric-innovation-in-pakistan-our-experience-and-a-call-to-action
#9
Walid Farooqi, Faysal Subhani, Asad Mian
Standardisation in paediatric medicine may have the unintended effect of stifling innovation. Thinking outside the box becomes even more important in low-income to middle-income countries like Pakistan, where a large paediatric population requires healthcare. In addition, there is always a lack of funds, making an innovative, low-cost and high impact solution all the more necessary. While regulation and formal research is an integral part of the process, the local synthesis of a solution must start with a creative idea...
May 26, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28549555/forensic-applications-of-y-chromosomal-properties
#10
REVIEW
Khushbukhat Khan, Muhammad Hassan Siddiqi, Maryam Abbas, Maha Almas, Muhammad Idrees
No abstract text is available yet for this article.
May 2017: Legal Medicine
https://www.readbyqxmd.com/read/28549206/assessment-of-allelic-diversity-among-drought-resistant-cotton-genotypes-using-microsatellite-markers
#11
A Javaid, F S Awan, F M Azhar, I A Khan
Drought, in conjunction with high temperature, is an important environmental constraint to cotton production. Development of cotton varieties with increased tolerance against adverse environmental conditions has been proposed as effective strategy for ensuring reliable yields. In the present study, 30 simple sequence repeat (SSR) primers were used to estimate genetic divergence among 22 cotton genotypes for drought stress tolerance. Genetic diversity is a prerequisite for developing drought resistant cotton genotypes...
May 25, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28549044/a-modified-suction-assisted-technique-of-transfer-of-diced-cartilage-graft-to-carrier-material-and-outcome-of-direct-injection-of-unwrapped-diced-cartilage-in-rhinoplasty
#12
Muhammad Mustehsan Bashir, Muhammad Sohail, Farid Ahmad Khan, Sadia Nosheen Jan, Hamid Hussain Ansari, Umer Nazir, Zohaib Hidayat
OBJECTIVE: To describe a modified suction-assisted technique (MSAT) of transfer of diced cartilage (DC) graft to a carrier material and to determine the clinical outcome of direct injection of unwrapped diced cartilage (UDC) in rhinoplasty. PLACE AND DURATION OF STUDY: Department of Plastic Surgery, KEMU, Mayo Hospital, Lahore from February 2011 to January 2015 METHODS:: Forty-seven patients of both genders with types 0 to 3 saddle nose deformity were included. Patients with types 4 and 5 saddle nose deformity, diabetes, hypertension, hepatic or renal disorders were excluded...
May 25, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28548645/waldenstrom-macroglobulinemia-cells-devoid-of-btk-c481s-or-cxcr4-whim-like-mutations-acquire-resistance-to-ibrutinib-through-upregulation-of-bcl-2-and-akt-resulting-in-vulnerability-towards-venetoclax-or-mk2206-treatment
#13
A Paulus, S Akhtar, H Yousaf, A Manna, S M Paulus, Y Bashir, T R Caulfield, M Kuranz-Blake, K Chitta, X Wang, Y Asmann, R Hudec, W Springer, S Ailawadhi, A Chanan-Khan
Although ibrutinib is highly effective in Waldenstrom macroglobulinemia (WM), no complete remissions in WM patients treated with ibrutinib have been reported to date. Moreover, ibrutinib-resistant disease is being steadily reported and is associated with dismal clinical outcome (overall survival of 2.9-3.1 months). To understand mechanisms of ibrutinib resistance in WM, we established ibrutinib-resistant in vitro models using validated WM cell lines. Characterization of these models revealed the absence of BTK(C481S) and CXCR4(WHIM-like) mutations...
May 26, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28548286/obesity-gets-on-your-renal-nerves
#14
EDITORIAL
Boye L Jensen
In the present issue of Acta Physiologica(1) , Khan et al. in their article "Improvement in baroreflex control of renal sympathetic nerve activity in obese Sprague-Dawley rats following immunosuppression" confirm that obesity-related hypertension involves resetting of the arterial baroreceptor to a state of less sensitivity and relate this mechanistically to inflammation-induced altered renal afferent nerve activity (1) . Pharmocological treatment with the calcineurin phosphatase inhibitor-type immunosuppressant tacrolimus attenuated inflammation, reversed, paradoxically, the hypertension and restored baroreceptor sensitivity similar to the effect of renal denervation...
May 26, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28547682/adherence-to-clinical-guidelines-and-the-potential-economic-benefits-of-admission-avoidance-for-acute-uncomplicated-diverticulitis
#15
I S Reynolds, E O'Connell, R M Heaney, W Khan, I Z Khan, R Waldron, K Barry
BACKGROUND: The treatment paradigm for acute diverticulitis is changing. There is an increasing trend towards managing patients with uncomplicated diverticulitis in the community. AIMS: The aim of this study was to analyse how acute diverticulitis is managed in our institution and also to analyse national data pertaining to treatment of acute diverticulitis. METHODS: A prospective database of all patients admitted to our institution over a 2-year period (2014-2016) with acute diverticulitis was maintained...
May 25, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28547097/patient-completed-or-symptom-based-screening-tools-for-endometriosis-a-scoping-review
#16
REVIEW
Eric Surrey, Cathryn M Carter, Ahmed M Soliman, Shahnaz Khan, Dana B DiBenedetti, Michael C Snabes
PURPOSE: The objective of this review was to evaluate existing patient-completed screening questionnaires and/or symptom-based predictive models with respect to their potential for use as screening tools for endometriosis in adult women. Validated instruments were of particular interest. METHODS: We conducted structured searches of PubMed and targeted searches of the gray literature to identify studies reporting on screening instruments used in endometriosis. Studies were screened according to inclusion and exclusion criteria that followed the PICOS (population, intervention, comparison, outcomes, study design) framework...
May 25, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28546946/comment-on-homozygosity-mapping-of-a-consanguineous-pakistani-family-affected-with-oculocutaneous-albinism-to-tyrosinase-gene
#17
Muzammil Ahmad Khan
No abstract text is available yet for this article.
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546110/hypoxia-driven-glycation-mechanisms-and-therapeutic-opportunities
#18
REVIEW
Mohammad Imran Khan, Suvasmita Rath, Vaqar Mustafa Adhami, Hasan Mukhtar
Tumor masses are deprived of oxygen and characterized by enhanced glucose uptake followed by glycolysis. Elevated glucose levels induce non-enzymatic glycosylation or glycation of proteins which leads to accumulation of advanced glycation end products (AGE). These AGE molecules bind to their respective receptors called the receptor for advanced glycation end products (RAGE) and initiate several aberrant signaling pathways leading to onset of diseases such as diabetes, Alzheimer's, atherosclerosis, heart failure and cancer...
May 22, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28545383/quinolinic-carboxylic-acid-derivatives-as-potential-multi-target-compounds-for-neurodegeneration-monoamine-oxidase-and-cholinesterase-inhibition
#19
Nehal Afreen Khan, Imtiaz Khan, Syed Mobasher Ali Abid, Sumera Zaib, Aliya Ibrar, Hina Andleeb, Shahid Hameed, Jamshed Iqbal
BACKGROUND: Parkinson&#039;s disease (PD), a debilitating and progressive disorder, is among the most challenging and devastating neurodegenerative diseases predominantly affecting the people over 60 years of age. OBJECTIVES: To confront PD, an advanced and operational strategy is to design single chemical functionality able to control more than one target instantaneously. METHODS: In this endeavor, for the exploration of new and efficient inhibitors of Parkinson&#039;s disease, we synthesized a series of quinoline carboxylic acids (3a‒j) and evaluated their in-vitro monoamine oxidase and cholinesterase inhibitory activities...
May 25, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28545379/tissue-engineering-in-achilles-tendon-reconstruction-the-role-of-stem-cells-growth-factors-and-scaffolds
#20
D S Pillai, Bal S Dhinsa, Wasim Khan
Achilles tendon injuries are common, and present a challenge in the acute and chronic setting. There is significant morbidity associated with the injury and the numerous management strategies, as well as financial implications to the patient and the health service. To date, repair tissue from all methods of management fail to achieve the same functional and biomechanical properties as the native tendon. The use of tissue engineering technology may reduce morbidity, improve the biomechanical properties of repair tissue and reduce the financial burden...
May 23, 2017: Current Stem Cell Research & Therapy
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