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Sinonasal adenocarcinoma

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https://www.readbyqxmd.com/read/28050382/intestinal-type-adenocarcinoma-from-inverted-papilloma-a-rare-recurrence
#1
Garima Singh, Meeta Singh, Mansi Chandana, Sompal Singh, Namrata Nargotra
Inverted Papilloma (IP) is an uncommon and locally aggressive benign tumour of sinonasal region, which tends to recur after surgical resection. Most tumours are confined to the lateral nasal wall and sinuses, with maxillary sinus being most commonly affected and a male preponderance. It has a known association with in situ and invasive carcinomas with a <10% rate of malignant transformation. Most common association has been seen with squamous cell carcinoma and extremely rare association with adenocarcinoma and small cell carcinoma...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28032937/prognostic-value-of-pretreatment-peripheral-blood-markers-in-paranasal-sinus-cancer-neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratio
#2
Mario Turri-Zanoni, Giovanni Salzano, Alessia Lambertoni, Marta Giovannardi, Apostolos Karligkiotis, Paolo Battaglia, Paolo Castelnuovo
BACKGROUND: Pretreatment hematological markers have emerged as prognostic factors for several cancers. The purpose of this study was to present our investigation of the value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting recurrence and mortality for patients with primary sinonasal cancers (SNCs). METHODS: We carried out a retrospective review of patients with SNC who had been treated using endoscopic approaches from 2002 to 2014 at a single institute...
December 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/28032289/sinonasal-renal-cell-like-carcinoma-case-report-and-review-of-the-literature
#3
Mark Kubik, Nicholas Barasch, Garret Choby, Raja Seethala, Carl Snyderman
The differential diagnosis for clear cell neoplasms of the sinonasal tract is wide but critical to understand. In this paper, we describe a case of renal cell-like adenocarcinoma (SNRCLA) presenting as a paranasal sinus mass with clear cell morphology. The relevant literature is reviewed and the workup for clear cell neoplasms described. SNRCLA is a rarely encountered low grade glandular malignancy of the paranasal sinuses. Despite its morphologic mimicry of renal cell carcinoma, SNRCLA demonstrates a seromucinous phenotype and is associated with a favorable prognosis and low recurrence rates after surgical resection...
December 28, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/28011123/sinonasal-adenocarcinoma-clinical-outcomes-and-predictive-factors
#4
J Michel, T Radulesco, M Penicaud, J Mancini, P Dessi
A retrospective study of 39 patients treated for sinonasal adenocarcinoma between 1995 and 2010 was performed. Epidemiological, clinical, histological, and therapeutic aspects of this series of patients were analyzed statistically and their impact in terms of overall and disease-free survival established using the Kaplan-Meier method. A search for prognostic factors was made using a log-rank test. The male to female sex ratio was 6.8 to 1. The average age at diagnosis was 65.7 years (range 40.2-85.6 years)...
December 20, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27916624/primary-paranasal-sinus-clear-cell-carcinoma-with-ewsr1-atf1-fusion-report-of-two-molecularly-confirmed-cases-exhibiting-unique-histopathology
#5
Jui Lan, Shun-Chen Huang, Yi-Hsien Chen, Wei-Chih Chen, Ying-Tai Jin, Ying-Chou Lu, Chih-Yen Chien, Hsuan-Ying Huang
Hyalinizing clear cell carcinoma (HCCC) is a rare low-grade tumor of the salivary glands made up of clear cells that form cords and nests in hyalinized stroma. To date, primary HCCCs of the paranasal sinus have not been described. This article presents two cases of HCCC of the maxillary sinus with unusual glandular formation and lymphoplasmacytic stroma in Case 1 and a characteristic solid nest pattern and fibrocellular and hyalinized stroma in Case 2. Immunohistochemical studies excluded myoepithelial origin and sinonasal renal cell-like adenocarcinomas...
December 1, 2016: Human Pathology
https://www.readbyqxmd.com/read/27859278/outcomes-of-nonsurgical-management-of-locally-advanced-carcinomas-of-the-sinonasal-cavity
#6
Shamit Chopra, Dev P Kamdar, David S Cohen, Lance K Heilbrun, Daryn Smith, Harold Kim, Ho-Sheng Lin, John R Jacobs, George Yoo
OBJECTIVE: To determine the outcome of definitive concurrent chemoradiation with platinum for locally advanced sinonasal carcinomas. STUDY DESIGN: Retrospective cohort. METHODS: Twenty-three nonsurgically and definitively treated patients diagnosed between July 1998 and February 2009 were analyzed. Patients with adenoid cystic carcinoma or adenocarcinoma were treated with photons and neutrons; the other histologies received photons alone. The vast majority received chemotherapy...
November 15, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27830670/sinonasal-adenocarcinoma-in-a-patient-without-exposure-to-risk-factors-case-report-and-review-of-the-literature
#7
Luciano Izzo, Sara Izzo, Pierfrancesco Di Cello, Vollono Laura, Violante Orazia, Gradini Roberto, Paolo Izzo
OBJECTIVE: Sinonasal adenocarcinoma is a tumor typically associated with exposure to occupational carcinogens. The International Agency for Research on Cancer (IARC) published several data in order to classify carcinogenic power of physical-chemical agents as far as sinonasal cancer is concerned. MATERIALS AND METHODS: We report a clinical case of sinonasal adenocarcinoma observed in an 84 years old patient, without clinical history of past exposure to carcinogens, smoke and alcohol...
July 29, 2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27681565/non-intestinal-type-sinonasal-cancers-and-exposure-to-occupational-carcinogens-a-case-control-study
#8
Matteo Bonzini, Nadia Facchinetti, Laura Zanetta, Davide Parassoni, Rossana Borchini, Paolo Battaglia, Mario Turri-Zanoni, Paolo Castelnuovo, Marco Mario Ferrario
BACKGROUND: Sinonasal cancers are rare, often fatal, tumors with a very high proportion of cases attributable to occupational exposures. The relevance of different carcinogens deeply varies among histological subtypes, with intestinal type adenocarcinomas (ITAC) characterized by a very large proportion of workers exposed to wood dust. The role of occupation in the etiology of other histotypes is less clear and more disputed, with authors questioning the possible occupational origin of non-ITAC cancers...
2016: La Medicina del Lavoro
https://www.readbyqxmd.com/read/27576899/relationship-between-18-fdg-pet-and-different-types-of-sinonasal-malignancies
#9
Marylisa Felix-Ravelo, Ayoub Bey, Fabien Arous, Solène Paris-Grandpierre, Roger Jankowski, Duc Trung Nguyen
CONCLUSION: The sensitivity and specificity of a (18)FDG-PET scan may be different according to the histology. The SUVmax and SUV ratio may reflect the tumor's aggressive behavior. OBJECTIVES: To describe the characteristics of PET/CT scans, including the maximum standard uptake values (SUVmax), at initial diagnosis according to six main types of sinonasal malignancies: sinonasal adenocarcinoma (SNAC), sinonasal undifferentiated carcinoma (SNUC), adenoid cystic carcinoma (ACC), sinonasal malignant melanoma (SMM), olfactory neuroblastoma (ONB), and sinonasal neuroendocrine carcinoma (SNEC)...
August 31, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27453718/a-case-case-study-on-sinonasal-cancer-prevention-effect-from-dust-reduction-in-woodworking-and-risk-of-mastic-solvents-in-shoemaking
#10
Enzo Emanuelli, Enrico Alexandre, Diego Cazzador, Vera Comiati, Tiziana Volo, Alessia Zanon, Maria Luisa Scapellato, Mariella Carrieri, Alessandro Martini, Giuseppe Mastrangelo
BACKGROUND AND AIMS: Sinonasal cancers (SNCs) are rare neoplasms, accounting for about 3 % of head and neck cancers, with squamous cell carcinoma (SCC) and adenocarcinoma (ADC) as the most common subtypes. ADCs present strong associations with occupational wood dust exposure. Preventive measures have progressively reduced wood dust concentrations in workplaces but no study has evaluated the effectiveness of such interventions. Few studies indicate associations between ADC and exposure to solvents, which is common in the shoe industry, but this hypothesis still needs confirmation...
2016: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/27402540/invasive-sinonasal-adenocarcinoma-with-an-absent-olfactory-bulb-a-case-report
#11
Thomas H Newman, Geoffrey A Tipper, Zakier Hussain
Sinonasal adenocarcinomas are rare, locally invasive tumours. In this case the symptomatic profile was unusual and the diagnosis was missed at the primary care stage. Interestingly this would be the first documented case with an absent ipsilateral olfactory bulb. A 55-year old male presented with symptoms of behavioural change and mild headaches. He was later found to have a large Sinonasal adenocarcinoma which penetrated the skull base. This was treated by a combined craniotomy and endonasal approach. Sinonasal adenocarcinomas are unusual tumours and further research is required in order to clarify management strategies and prognosis...
2016: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/27363404/comparison-of-endoscopic-and-external-resections-for-sinonasal-instestinal-type-adenocarcinoma
#12
Geoffrey Mortuaire, Xavier Leroy, Claire Vandenhende-Szymanski, Dominique Chevalier, Anne-Sophie Thisse
Endoscopic sinus surgery (ESS) is considered as a valid option in the management of nasal adenocarcinoma (ADC). Comparative studies with open approaches are still required. A monocentric retrospective study was carried out from May 2002 to December 2013, including 43 patients with intestinal-type adenocarcinoma of the ethmoid sinus. Non-resectable tumours or recurrences were excluded. Before 2008, open approach with lateral rhinotomy (LR) was performed as the gold standard of treatment. From 2008, ESS was systematically used as a first-line option as long as a complete resection was achievable...
June 30, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27301901/gene-methylation-profiling-in-sinonasal-adenocarcinoma-and-squamous-cell-carcinoma
#13
Maria Costales, Alejandro López-Hernández, Cristina García-Inclán, Blanca Vivanco, Fernando López, José Luis Llorente, Mario A Hermsen
OBJECTIVE: To identify epigenetic events in intestinal-type sinonasal adenocarcinoma (ITAC) and sinonasal squamous cell carcinoma (SNSCC) and to evaluate their relation to clinicopathologic features and follow-up data. STUDY DESIGN: Retrospective study. SETTING: Academic research hospital. SUBJECTS AND METHODS: The methylation status of 23 genes in 50 ITACs and 32 SNSCCs was analyzed by methylation-specific multiplex ligation-dependent probe amplification and its relation to clinicopathologic features and follow-up data...
June 14, 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27258560/the-role-of-satb2-as-a-diagnostic-marker-of-sinonasal-intestinal-type-adenocarcinoma
#14
Alena Skalova, Aylin Sar, Jan Laco, Alena Metelkova, Marketa Miesbauerova, Petr Steiner, Marian Švajdler, Michal Michal
BACKGROUND: Intestinal-type adenocarcinoma (ITAC) of the nasal cavity and paranasal sinuses is an uncommon tumor associated with exposure to wood and leather dust, nickel, and possibly smoking. ITAC shares phenotypical features with colorectal carcinoma. In contrast to most non-intestinal-type sinonasal adenocarcinomas, ITAC is an aggressive adenocarcinoma with poor clinical outcome; therefore, its reliable separation from non-ITAC is very important. AIM: The use of a combination of immunohistochemical markers of intestinal differentiation was tested in a cohort of sinonasal carcinomas of different types...
June 2, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27224655/intestinal-type-sinonasal-adenocarcinomas-the-road-to-molecular-diagnosis-and-personalized-treatment
#15
REVIEW
Ann Hoeben, Linda van de Winkel, Frank Hoebers, Kenneth Kross, Chantal Driessen, Pieter Slootweg, Vivianne C G Tjan-Heijnen, Carla van Herpen
BACKGROUND: Sinonasal intestinal-type adenocarcinomas (ITACs) are epithelial tumors of the nasal cavity and the paranasal sinuses, often related to professional exposure to organic dust, mainly wood or leather. It is a rare cancer. If resectable, surgery is the treatment of choice. Postoperative radiotherapy is often indicated to increase local control. Systemic treatment (chemotherapy, targeted agents, or immunotherapy) of irresectable ITACs and/or metastasized disease is less standardized...
October 2016: Head & Neck
https://www.readbyqxmd.com/read/27194879/sinonasal-teratocarcinosarcoma-case-report-of-an-unusual-neoplasm
#16
Soham Chakraborty, Anadi Roy Chowdhury, Goutam Bandyopadhyay
Sinonasal teratocarcinosarcoma is an extremely rare malignant tumor arising in the sinonasal tract, having combined histological features of teratoma and carcinosarcoma. Here, we are presenting a case of sinonasal teratocarcinosarcoma in a 28-year-old male patient. A 28-year-old male patient presented with left-sided nasal obstruction and recurrent epistaxis for last 2 months. On examination, a polypoid mass was noted in the left nasal cavity. The mass was surgically resected. Paraffin-embedded sections were made and stained with hematoxylin and eosin...
January 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27183864/absence-of-chromosomal-translocations-and-protein-expression-of-alk-in-sinonasal-adenocarcinomas
#17
Esteban Pacheco, José Luis Llorente, Alejandro López-Hernández, Cristina García-Inclán, María Costales, Sira Potes Ares, Fernando López, Blanca Vivanco, Mario A Hermsen
INTRODUCTION: Chromosomal translocations at 2p23 cause overexpression of anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase involved in signalling pathways that regulate cell proliferation. This translocation occurs in 5% of lung adenocarcinoma and has been demonstrated to be useful as a therapeutic target for crizotinib. sinonasal adenocarcinomas (SNAC) are histologically similar to lung adenocarcinomas; the aim of this study was to evaluate the presence of ALK alterations in SNAC...
May 13, 2016: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/27165676/endoscopic-resection-of-sinonasal-malignancy-a-systematic-review-and-meta-analysis
#18
REVIEW
Rounak B Rawal, Zainab Farzal, Jerome J Federspiel, Satyan B Sreenath, Brian D Thorp, Adam M Zanation
OBJECTIVES: The use of endoscopic approaches for sinonasal malignancy resection has increased, but survival data are limited secondary to disease rarity and new surgical technique. Here we present a systematic review and meta-analysis of endoscopic endonasal resection of sinonasal malignancy. DATA SOURCES: MEDLINE, PubMed Central, NCBI Bookshelf, Cochrane Library, clinicaltrials.gov, National Guideline Clearinghouse. REVIEW METHODS: PRISMA/MOOSE guidelines were followed...
September 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27107016/recurrent-dna-copy-number-alterations-in-intestinal-type-sinonasal-adenocarcinoma
#19
J Perez-Escuredo, A Lopez-Hernandez, M Costales, F Lopez, S P Ares, B Vivanco, J L Llorente, M A Hermsen
BACKGROUND: Intestinal-type sinonasal adenocarcinoma (ITAC) is a rare tumour related to occupational wood dust exposure. Few studies have described recurrent genetic changes on a genome-wide scale. The aim of this study was to obtain a high resolution map of recurrent genetic alterations in ITAC. MATERIAL AND METHODS: Copy number alterations were evaluated by microarray CGH and MLPA in 37 primary tumours. The results were correlated with pathological characteristics and clinical outcome...
September 2016: Rhinology
https://www.readbyqxmd.com/read/27080391/salivary-duct-carcinoma-of-the-sinonasal-cavity-a-case-report-and-review-of-the-literature
#20
Sarina Müller, Konstantinos Mantsopoulos, Heinrich Iro, Abbas Agaimy
BACKGROUND: Salivary duct carcinoma is a rare, aggressive tumor entity first described by Kleinsasser et al in 1968, as a group of malignant salivary gland tumors characterized by duct formation and central necrosis. A case with an unusual localization in the nasal cavity and maxillary sinus is being described in our report. METHODS: A 60-year-old patient presented with difficulty of nasal breathing and recurrent episodes of epistaxis from the left nasal cavity over the previous 3 months...
August 2016: Head & Neck
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