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https://www.readbyqxmd.com/read/28259583/positive-association-between-short-term-ambient-air-pollution-exposure-and-children-blood-pressure-in-china-result-from-the-seven-northeast-cities-snec-study
#1
Xiao-Wen Zeng, Zhengmin Min Qian, Michael G Vaughn, Erik J Nelson, Shyamali C Dharmage, Gayan Bowatte, Jennifer Perret, Duo-Hong Chen, Huimin Ma, Shao Lin, Benjamin de Foy, Li-Wen Hu, Bo-Yi Yang, Shu-Li Xu, Chuan Zhang, Yan-Peng Tian, Min Nian, Jia Wang, Xiang Xiao, Wen-Wen Bao, Ya-Zhi Zhang, Guang-Hui Dong
The impact of ambient air pollution on health causes concerns in China. However, little is known about the association of short-term air pollution exposure with blood pressure (BP) in children. The goal of present study was to assess the association between short-term air pollution and BP in children from a highly polluted area in China. This study enrolled 9354 children in 24 elementary and middle schools (aged 5-17 years) from the Seven Northeast Cities (SNEC) study, respectively, during the period of 2012-2013...
March 2, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28151586/nuclear-erythroid-2-related-factor-2-activation-inhibits-house-dust-mite-induced-sinonasal-epithelial-cell-barrier-dysfunction
#2
Nyall R London, Anuj Tharakan, Andrew P Lane, Shyam Biswal, Murugappan Ramanathan
BACKGROUND: Dysregulated sinonasal epithelial cell (SNEC) barrier function has been proposed to contribute to the pathogenesis of sinonasal inflammatory conditions such as allergic rhinitis (AR) and chronic rhinosinusitis (CRS). Allergens such as house dust mite (HDM) have been reported to disrupt SNEC barrier integrity. We have recently identified nuclear erythroid 2-related factor 2 (Nrf2) activation via sulforaphane (SFN) stimulation to stabilize SNEC barrier function. The purpose of this study was to explore whether Nrf2 activation could ameliorate HDM-induced SNEC barrier dysfunction...
February 2, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28117948/bactericidal-antibiotics-promote-oxidative-damage-and-programmed-cell-death-in-sinonasal-epithelial-cells
#3
Michael A Kohanski, Anuj Tharakan, Nyall R London, Andrew P Lane, Murugappan Ramanathan
BACKGROUND: Antibiotics are widely and heavily used in the treatment of chronic sinusitis. Bactericidal antibiotics can stimulate reactive oxygen species (ROS) formation, a proinflammatory response, and cell death in cultured human sinonasal epithelial cells (SNECs). Sulforaphane (SFN) is a potent stimulator of the antioxidant nuclear factor erythroid 2-related factor 2 (Nrf-2) system and a suppressor of inflammation. In this study we utilized SFN to further explore the relationship between levofloxacin treatment, ROS formation, and the cell death response...
April 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28092910/effects-of-in-utero-and-postnatal-exposure-to-secondhand-smoke-on-lung-function-by-gender-and-asthma-status-the-seven-northeastern-cities-snec-study
#4
Li-Wen Hu, Mo Yang, Shu Chen, Kuntal Shah, Yismaw Hailegiorgis, Richai Burgens, Michael Vaughn, Jin Huang, Pamela Xaverius, Gunther Paul, Lidia Morawska, Tao Lu, Shao Lin, Shou-Qiang Zhong, Min-Li Kong, Yan-Qi Xie, Yuan-Tao Hao, Xiao-Wen Zeng, Zhengmin Qian, Guang-Hui Dong
BACKGROUND: Little information exists on whether gender or asthma status modifies the effects of secondhand smoke (SHS) exposure on lung function. OBJECTIVE: To evaluate whether gender or asthma status modifies the association of SHS exposure with lung function. METHODS: A total of 6,740 children (average 11.6 years) were recruited from 24 districts of 7 cities in northeast China in 2012. SHS exposure included exposure to environmental and maternal smoking both in utero and during early childhood (postnatal)...
2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27938993/meta-analysis-of-701-published-cases-of-sinonasal-neuroendocrine-carcinoma-the-importance-of-differentiation-grade-in-determining-treatment-strategy
#5
REVIEW
Tom P van der Laan, René Iepsma, Max J H Witjes, Bernard F A M van der Laan, Boudewijn E C Plaat, Gyorgy B Halmos
The aim of this meta-analysis was to provide treatment guidelines for sinonasal neuroendocrine carcinoma (SNC) by combining all available data in the literature. A literature search for all studies concerning SNC was performed against the MEDLINE and EMBASE databases. Available clinical data was normalized, pooled, and statistically analyzed. A total of 701 cases of SNC were available for analysis, comprising 127 well or moderately differentiated sinonasal neuroendocrine carcinomas (SNEC), 459 sinonasal undifferentiated carcinoma (SNUC) and 115 sinonasal small cell carcinoma (SmCC)...
December 2016: Oral Oncology
https://www.readbyqxmd.com/read/27857871/sinonasal-carcinomas-with-neuroendocrine-features-histopathological-differentiation-and-treatment-outcomes
#6
Liuba Soldatova, Raewyn G Campbell, Ricardo L Carrau, Daniel M Prevedello, Paul Wakely, Bradley A Otto, Leo F Ditzel Filho
Objectives Sinonasal cancers with neuroendocrine features share similar clinical, radiological, and histopathological features; however, these tumors often exhibit varying degrees of aggressive behavior presenting significant treatment challenges. The objective of this study was to report our experience with these rare malignancies and to present a review of current literature. Methods Following institutional review board approval, the records of all patients with biopsy-proven sinonasal malignancies over a 5-year period were reviewed...
December 2016: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/27616464/comparison-of-body-mass-index-with-abdominal-obesity-for-identifying-elevated-blood-pressure-in-children-and-adolescents-the-snec-study
#7
Ping Yuan, Zhengmin Min Qian, Michael Vaughn, Jin Huang, Patrick Ward, Yu Zhu, Xiao-Di Qin, Yang Zhou, Meng Li, Shuli Xu, Ya-Zhi Zhang, Wen-Wen Bao, Yuan-Tao Hao, Xiao-Wen Zeng, Guang-Hui Dong
Body mass index (BMI) and waist circumference (WC) are two common ways to measure obesity. There is a debate, however, about which of these two measures are more closely associated with elevated blood pressure (BP). The aim of this study is to investigate the prevalence of obesity and whether BMI and WC is better associated with elevated BP in children and adolescents. A representative sample of 8613 Chinese youth aged 7-17 years from seven cities in Northeastern China was selected and measurements of height, weight, WC, BP were taken from 2012 to 2013...
September 5, 2016: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/27580429/reversal-of-cigarette-smoke-extract-induced-sinonasal-epithelial-cell-barrier-dysfunction-through-nrf2-activation
#8
Anuj Tharakan, Ashleigh A Halderman, Andrew P Lane, Shyam Biswal, Murugappan Ramanathan
BACKGROUND: Environmental factors such as inhaled pollutants like cigarette smoke may play a significant role in diseases of the upper airway including chronic rhinosinusitis (CRS). Recent studies have shown that cigarette smoke causes impaired airway epithelial cell barrier function likely through environmental oxidative stress related pathways. The purpose of this study is to explore whether enhancing nuclear factor erythroid 2 [NF-E2]-related factor 2 [Nrf2], the body's master antioxidant system, can ameliorate cigarette smoke-induced sinonasal epithelial cell (SNEC) barrier dysfunction...
November 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27576899/relationship-between-18-fdg-pet-and-different-types-of-sinonasal-malignancies
#9
Marylisa Felix-Ravelo, Ayoub Bey, Fabien Arous, Solène Paris-Grandpierre, Roger Jankowski, Duc Trung Nguyen
CONCLUSION: The sensitivity and specificity of a (18)FDG-PET scan may be different according to the histology. The SUVmax and SUV ratio may reflect the tumor's aggressive behavior. OBJECTIVES: To describe the characteristics of PET/CT scans, including the maximum standard uptake values (SUVmax), at initial diagnosis according to six main types of sinonasal malignancies: sinonasal adenocarcinoma (SNAC), sinonasal undifferentiated carcinoma (SNUC), adenoid cystic carcinoma (ACC), sinonasal malignant melanoma (SMM), olfactory neuroblastoma (ONB), and sinonasal neuroendocrine carcinoma (SNEC)...
February 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27529044/an-extremely-rare-case-of-advanced-metastatic-small-cell-neuroendocrine-carcinoma-of-sinonasal-tract
#10
Yu Yu Thar, Poras Patel, Tiangui Huang, Elizabeth Guevara
Small cell neuroendocrine carcinoma (SNEC) is a rare form of malignancy. It mainly presents as bronchogenic neoplasm, and the extrapulmonary form accounts for only 0.1% to 0.4% of all cancers. These extrapulmonary tumors have been described most frequently in the urinary bladder, prostate, esophagus, stomach, colon and rectum, gall bladder, head and neck, cervix, and skin. Primary SNEC of the sinonasal tract is extremely rare with only less than 100 cases reported in the literature. Because of extreme rarity and aggressiveness of the tumor, the management for this entity varies considerably mandating multimodality approach...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27197933/the-antecedents-and-correlates-of-necrotizing-enterocolitis-and-spontaneous-intestinal-perforation-among-infants-born-before-the-28th-week-of-gestation
#11
R Singh, B Shah, E N Allred, M Grzybowski, C R Martin, A Leviton
OBJECTIVE: To identify antecedents of "medical" necrotizing enterocolitis (mNEC), "surgical" NEC (sNEC), and spontaneous intestinal perforation (SIP) in newborns delivered before 28 weeks gestation. STUDY DESIGN: Prospective multicenter cohort study. During study period, 2002- 2004, women delivering before 28 weeks gestation at one of 14 participating institutions were enrolled. Well defined antenatal and postnatal variables were collected. Bivariate analyses were performed to identify candidates for developing multinomial multivariable time-oriented logistic regression models...
May 19, 2016: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/26995520/blood-transfusions-increased-rates-of-surgical-nec-and-lower-survival-a-propensity-score-matched-analysis
#12
Arash J Sayari, Jun Tashiro, Juan E Sola, Eduardo A Perez
PURPOSE: We sought to investigate the association between blood transfusions (BT), rates of necrotizing enterocolitis requiring surgical intervention (SNEC), and survival. METHODS: Blood transfusions in premature infants were identified in the Kids' Inpatient Database (2003-2009). Propensity score-matched analysis compared SNEC outcomes in BT vs. non-BT groups. Multivariate analyses were performed to determine independent predictors of outcome. RESULTS: Overall, 663740 cases were identified and 4...
June 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/26624249/bactericidal-antibiotics-promote-reactive-oxygen-species-formation-and-inflammation-in-human-sinonasal-epithelial-cells
#13
Michael A Kohanski, Anuj Tharakan, Andrew P Lane, Murugappan Ramanathan
BACKGROUND: Bactericidal antibiotics have been shown to stimulate reactive oxygen species (ROS) formation in mammalian cells through mitochondrial dysfunction. This results in oxidative tissue damage that may have negative consequences for long-term antibiotic use. Antibiotics are widely and heavily used in the treatment of acute and chronic sinusitis; however, the relationship between antibiotics and ROS formation in sinonasal epithelial cells (SNECs) has not yet been demonstrated. METHODS: Human SNECs were collected from patients during endoscopic sinus surgery and grown in culture at the air-liquid interface...
February 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/26622589/primary-small-cell-neuroendocrine-carcinoma-of-the-oral-cavity-a-case-report-and-review-of-the-literature
#14
Ming Zeng, Shao-Dong Yang, Jia-Li Zhang, Xin-Ming Chen
Small cell neuroendocrine carcinoma (SNEC) of the oral cavity is a rare and distinctive tumor with aggressive clinical behavior. Thus far, only a small number of cases have been reported and no definitive standard treatment strategy has been determined. The current study reports a case of oral SNEC arising in the lower gingiva in a 73-year-old male. Computed tomography displayed a relatively well-defined mass measuring 2.8×2×1.4 cm in size. The mass was located in the buccal side of the right mandibular posterior gingiva and exhibited no bony involvement...
August 2015: Oncology Letters
https://www.readbyqxmd.com/read/26618514/sialylation-of-anti-histone-immunoglobulin-g-autoantibodies-determines-their-capabilities-to-participate-in-the-clearance-of-late-apoptotic-cells
#15
I Magorivska, L E Muñoz, C Janko, T Dumych, J Rech, G Schett, F Nimmerjahn, R Bilyy, M Herrmann
The Fc portion of immunoglobulin (Ig)G harbours a single glycosylation site. Glycan sialylation is critical for structure and for certain effector functions of IgG. Anti-histone IgG of patients with systemic lupus erythematosus is reportedly responsible for the recruitment of polymorphonuclear cells (PMN) to the clearance of apoptotic cells. Autoantibodies decorating secondary necrotic cells (SNEC) induce proinflammatory responses after activation of blood-borne phagocytes. Analysing the sialylation status of affinity-purified anti-histone IgG in patients with systemic lupus erythematosus (SLE), we demonstrated that the anti-histone IgG was contained preferentially in the non-sialylated fraction...
April 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/26446390/epidemiology-of-elevated-blood-pressure-and-associated-risk-factors-in-chinese-children-the-snec-study
#16
MULTICENTER STUDY
Y Zhou, Z Qian, M G Vaughn, B B Boutwell, M Yang, X-W Zeng, R-Q Liu, X-D Qin, Y Zhu, G-H Dong
Despite the association of childhood blood pressure (BP) with hypertension later in the life course, there remains dearth of information regarding the prevalence and emergence of hypertension in children, especially in China. To investigate the current status of BP, prevalence of elevated BP and related factors in Chinese children, a cross-sectional survey in a representative sample of 9354 Chinese children 5-17 years old was conducted in seven cities in Northeastern China during 2011 and 2012. BP measurements were taken by mercury sphygmomanometer...
April 2016: Journal of Human Hypertension
https://www.readbyqxmd.com/read/26264239/breastfeeding-modifies-the-effects-of-environment-tobacco-smoke-exposure-on-respiratory-diseases-and-symptoms-in-chinese-children-the-seven-northeast-cities-study
#17
Y-Q Liu, Z Qian, J Wang, T Lu, S Lin, X-W Zeng, R-Q Liu, Y Zhu, X-D Qin, P Yuan, Y Zhou, M Li, Y-T Hao, G-H Dong
To evaluate the potential effect of interaction between breastfeeding and environmental tobacco smoke (ETS) exposure on respiratory health, we studied 31 049 children (aged 2-14 years) from 25 districts of seven cities in northeast China. Parents of the children completed standardized questionnaires that characterized the children's histories of respiratory symptoms and illness, feeding methods, ETS exposure, and other associated risk factors. Breastfeeding was defined as having been mainly breastfed for 3 months or more...
August 2016: Indoor Air
https://www.readbyqxmd.com/read/26032193/graft-failure-and-intraocular-pressure-control-after-keratoplasty-in-iridocorneal-endothelial-syndrome
#18
MULTICENTER STUDY
Desmond Tung-Lien Quek, Chee Wai Wong, Tina T Wong, Sang Beom Han, Hla Myint Htoon, Ching Lin Ho, Donald T Tan, Francis W Price, Marianne O Price, Jodhbir S Mehta
PURPOSE: To describe and compare graft survival and intraocular pressure (IOP) control after penetrating keratoplasty (PK) and Descemet stripping automated endothelial keratoplasty (DSAEK) in eyes with iridocorneal endothelial (ICE) syndrome. DESIGN: Retrospective case series. METHODS: Multicenter study conducted at the Singapore National Eye Centre (SNEC) and Price Vision Group. Twenty-nine consecutive eyes with ICE syndrome that underwent keratoplasty between 1991 and 2011 were identified from the SNEC transplant database and Price Vision Group patient database and the following data extracted: demographics, graft failure, IOP indices, and glaucoma treatment pre- and postkeratoplasty...
September 2015: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/25907801/proinflammatory-mediators-alter-expression-of-nuclear-factor-kappa-b-regulating-deubiquitinases-in-sinonasal-epithelial-cells
#19
Ping Li, Ying Wang, Justin H Turner
BACKGROUND: Nuclear factor κB (NF-κB) is a vital transcription factor that is activated by numerous inflammatory stimuli. Its activity is tightly regulated by a family of deubiquitinating enzymes (A20, Cezanne, cylindromatosis [CYLD]) that function in a negative-feedback loop, a process that prevents chronic and systemic inflammation. This study seeks to characterize the expression and functional role of NF-κB-regulating deubiquitinases in the sinonasal epithelium. METHODS: Expression of A20, Cezanne, and CYLD was assessed in normal sinonasal tissue using immunohistochemistry...
July 2015: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/25888820/the-ct-and-mri-observations-of-small-cell-neuroendocrine-carcinoma-in-paranasal-sinuses
#20
Qingqiang Zhu, Wenrong Zhu, Jingtao Wu, Hongying Zhang
BACKGROUND: Primary small cell neuroendocrine carcinoma (SNEC) of paranasal sinuses is an extremely rare malignant tumor known for its aggressive clinical behavior. METHODS: Nineteen patients with SNEC in paranasal sinuses by magnetic resonance imaging (MRI) (n = 19) and computerized tomography (CT) and MRI (n = 18) were retrospectively studied. CT and MRI were undertaken to investigate tumor features. RESULTS: The lesions were located in the ethmoidal sinus (n = 6), maxillary sinus (n = 4), and bilateral sphenoid sinus (n = 9)...
2015: World Journal of Surgical Oncology
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