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https://www.readbyqxmd.com/read/28647916/impact-of-site-selection-and-study-conduct-on-outcomes-in-global-clinical-trials
#1
REVIEW
Chaudhry M S Sarwar, Muthiah Vaduganathan, Javed Butler
PURPOSE OF REVIEW: There are over 25 million patients living with heart failure globally. Overall, and especially post-discharge, clinical outcomes have remained poor in heart failure despite multiple trials, with both successes and failures over the last two decades. Matching therapies to the right patient population, identifying high-quality sites, and ensuring optimal trial design and execution represent important considerations in the development of novel therapeutics in this space...
June 24, 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28647761/tourism-climatology-past-and-present-a-review-of-the-role-of-the-isb-commission-on-climate-tourism-and-recreation
#2
C R de Freitas
The Executive Board of the International Society of Biometeorology (ISB) founded the Commission on Climate, Tourism and Recreation (CCTR) at the 15th International Congress of Biometeorology in Sydney, Australia in 1999. The aims of the CCTR are to bring together researchers from around the world to critically review the current state of knowledge in tourism and recreation climatology and explore possibilities for future research. Almost two decades on, research in tourism climatology has developed and expanded due in large part to the initiatives and activities of the CCTR and several collaborative research projects run under the auspices of the CCTR...
June 24, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28647606/role-of-streptomyces-pactum-in-phytoremediation-of-trace-elements-by-brassica-juncea-in-mine-polluted-soils
#3
Amjad Ali, Di Guo, Amanullah Mahar, Zhen Wang, Dost Muhammad, Ronghua Li, Ping Wang, Feng Shen, Quanhong Xue, Zengqiang Zhang
The industrial expansion, smelting, mining and agricultural practices have increased the release of toxic trace elements (TEs) in the environment and threaten living organisms. The microbe-assisted phytoremediation is environmentally safe and provide an effective approach to remediate TEs contaminated soils. A pot experiment was conducted to test the potential of an Actinomycete, subspecies Streptomyces pactum (Act12) along with medical stone compost (MSC) by growing Brassica juncea in smelter and mines polluted soils of Feng County (FC) and Tongguan (TG, China), respectively...
June 22, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28647548/the-bioeconomy-in-poland-within-the-context-of-the-european-union
#4
REVIEW
Ewa Woźniak, Tomasz Twardowski
This article outlines the potential of the development of bioeconomy in Poland in the context of the European Union (EU). The analyses take into account the concept of bioeconomy, the overview of documents referring to the bioeconomy in the EU, including policy frameworks and agendas. Many countries including Poland emphasise the importance of bioeconomy, but have not yet developed a complex strategy. The state of bioeconomy in Poland is characterised by the sectors of agriculture, forestry and food production, as well as parts of the chemical, biotechnology and energy industries...
June 21, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28647529/-linking-secondary-metabolites-to-biosynthesis-genes-in-the-fungal-endophyte-cyanodermella-asteris-the-anti-cancer-bisanthraquinone-skyrin
#5
Linda Jahn, Thomas Schafhauser, Daniel Wibberg, Christian Rückert, Anika Winkler, Andreas Kulik, Tilmann Weber, Liane Flor, Karl-Heinz van Pée, Jörn Kalinowski, Jutta Ludwig-Müllera, Wolfgang Wohlleben
Fungal aromatic polyketides display a very diverse and widespread group of natural products. Due to their excellent light absorption properties and widely studied biological activities, they offer numerous application for food, textile and pharmaceutical industry. The biosynthetic pathways of fungal aromatic polyketides usually involve a set of successive enzymes, in which a non-reductive polyketide synthases iteratively catalyzes the essential assembly of simple building blocks into (often polycyclic) aromatic compounds...
June 21, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28647528/the-linkage-between-nutrient-supply-intracellular-enzyme-abundances-and-bacterial-growth-new-evidences-from-the-central-carbon-metabolism-of-corynebacterium-glutamicum
#6
Stephan Noack, Raphael Voges, Jochem Gätgens, Wolfgang Wiechert
Corynebacterium glutamicum serves as important production host for small molecular compounds that are derived from precursor molecules of the central carbon metabolism. It is therefore a well-studied model organism of industrial biotechnology. However, a deeper understanding of the regulatory principles underlying the synthesis of central metabolic enzymes under different environmental conditions as well as its impact on cell growth is still missing. We studied enzyme abundances in C. glutamicum in response to growth on: i) one limiting carbon source by sampling chemostat and fed-batch cultivations and ii) changing carbon sources provided in excess by sampling batch cultivations...
June 21, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28647504/antimicrobial-investigation-of-selected-soil-actinomycetes-isolated-from-unexplored-regions-of-kashmir-himalayas-india
#7
Aabid Manzoor Shah, Shakeel-U Rehman, Aehtesham Hussain, Saleem Mushtaq, Muzafar Ahmad Rather, Aiyatullah Shah, Zahoor Ahmad, Inshad Ali Khan, Khursheed Ahmad Bhat, Qazi Parvaiz Hassan
The aim of the present study was to isolate and evaluate the antimicrobial potential of soil actinomycetes of Kashmir Himalayas. The secondary metabolites of actinomycetes are the prominent source of antibiotics. A total of 121 morphologically different actinomycete strains were isolated and screened for antimicrobial activity against various human pathogens. The ethyl acetate extract of fermented broth an actinomycete strain, identified as Streptomyces pratensis exhibited significant antimicrobial activity against Staphylococcus aureus ATCC 29213 with MIC 0...
June 21, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28647334/test-characteristics-of-milk-amyloid-a-elisa-somatic-cell-count-and-bacteriological-culture-for-detection-of-intramammary-pathogens-that-cause-subclinical-mastitis
#8
S Jaeger, F Virchow, P R Torgerson, M Bischoff, B Biner, S Hartnack, S R Rüegg
Bovine mastitis is an important disease in the dairy industry, causing economic losses as a result of withheld milk and treatment costs. Several studies have suggested milk amyloid A (MAA) as a promising biomarker in the diagnosis of mastitis. In the absence of a gold standard for diagnosis of subclinical mastitis, we estimated the diagnostic test accuracy of a commercial MAA-ELISA, somatic cell count (SCC), and bacteriological culture using Bayesian latent class modeling. We divided intramammary infections into 2 classes: those caused by major pathogens (e...
June 21, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28647330/effect-of-high-hydrostatic-pressure-treated-skim-milk-on-permeate-flux-and-fouling-during-ultrafiltration
#9
Mathilde Leu, Alice Marciniak, Julien Chamberland, Yves Pouliot, Laurent Bazinet, Alain Doyen
Ultrafiltration (UF) is largely used in the dairy industry to generate milk and whey protein concentrate for standardization of milk or production of dairy ingredients. Recently, it was demonstrated that high hydrostatic pressure (HHP) extended the shelf life of milk and improved rennet coagulation and cheese yield. Pressurization also modified casein micelle size distribution and promoted aggregation of whey proteins. These changes are likely to affect UF performance. Consequently, this study will determine the effect of skim milk pressurization (300 and 600 MPa, 5 min) on UF performance in terms of permeate flux decline and fouling...
June 21, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28647321/development-of-large-scale-and-economic-ph-control-system-for-outdoor-cultivation-of-microalgae-haematococcus-pluvialis-using-industrial-flue-gas
#10
Yoon Young Choi, Jae Min Joun, Jeewon Lee, Min Eui Hong, Hoang-Minh Pham, Won Seok Chang, Sang Jun Sim
The aim of this study was to develop the economic and effective buffer system for microalgae mass cultivation using industrial flue gas. Due to the continuous flue gas supplement, culture media acidified, therefore cell growth inhibited. Although buffering agent was added, this result increase in cost for overall culture process. Therefore combined buffer system of bicarbonate and phosphate (BP) for large-scale use was investigated. The bicarbonate buffer system generated from CO2 dissolution, additionally phosphate buffer system improves the buffer performance under the continuous CO2 supplementation from flue gas...
May 26, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28647270/polycyclic-aromatic-hydrocarbons-in-ambient-air-surface-soil-and-wheat-grain-near-a-large-steel-smelting-manufacturer-in-northern-china
#11
Weijian Liu, Yilong Wang, Yuanchen Chen, Shu Tao, Wenxin Liu
The total concentrations and component profiles of polycyclic aromatic hydrocarbons (PAHs) in ambient air, surface soil and wheat grain collected from wheat fields near a large steel-smelting manufacturer in Northern China were determined. Based on the specific isomeric ratios of paired species in ambient air, principle component analysis and multivariate linear regression, the main emission source of local PAHs was identified as a mixture of industrial and domestic coal combustion, biomass burning and traffic exhaust...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28647262/development-of-a-hybrid-photo-bioreactor-and-nanoparticle-adsorbent-system-for-the-removal-of-co2-and-selected-organic-and-metal-co-pollutants
#12
Andrea A Rocha, Christian Wilde, Zhenzhong Hu, Oleg Nepotchatykh, Yevgen Nazarenko, Parisa A Ariya
Fossil fuel combustion and many industrial processes generate gaseous emissions that contain a number of toxic organic pollutants and carbon dioxide (CO2) which contribute to climate change and atmospheric pollution. There is a need for green and sustainable solutions to remove air pollutants, as opposed to conventional techniques which can be expensive, consume additional energy and generate further waste. We developed a novel integrated bioreactor combined with recyclable iron oxide nano/micro-particle adsorption interfaces, to remove CO2, and undesired organic air pollutants using natural particles, while generating oxygen...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28647259/effect-of-current-emission-abatement-strategies-on-air-quality-improvement-in-china-a-case-study-of-baotou-a-typical-industrial-city-in-inner-mongolia
#13
Xionghui Qiu, Lei Duan, Siyi Cai, Qian Yu, Shuxiao Wang, Fahe Chai, Jian Gao, Yanping Li, Zhaoming Xu
The national Air Pollution Prevention and Control Action Plan required significant decreases in PM2.5 levels over China. To explore more effective emission abatement strategies in industrial cities, a case study was conducted in Baotou to evaluate the current national control measures. The total emissions of SO2, NOX, PM2.5 and NMVOC (non-methane volatile organic compounds) in Baotou were 211.2Gg, 156.1Gg, 28.8Gg, and 48.5Gg, respectively in 2013, and they would experience a reduction of 30.4%, 26.6%, 15.1%, and 8...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28647248/synergetic-analysis-of-springtime-air-pollution-episodes-over-gwangju-korea
#14
Sung-Kyun Shin, Kwon-Ho Lee, Seung-Shik Park, Man Sing Wong
The characteristics of springtime aerosols, including their optical and microphysical properties, were analyzed for the months of March to May of 2009 in Gwangju (35.23°N, 126.84°E), Korea. A high Light Detection and Ranging (LIDAR)-derived aerosol depolarization ratio (δ) of 0.25±0.04 was determined on dust particles during the observation period. The Ångström exponent values of the 440-870nm wavelength pair (Å440-870) and single-scattering albedo at 675nm (Ω675) measured by a CIMEL sun/sky radiometer were 0...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28647223/fluid-dynamics-model-on-fluidized-bed-gasifier-using-agro-industrial-biomass-as-fuel
#15
Tamer M Ismail, M Abd El-Salam, Eliseu Monteiro, Abel Rouboa
The present study shows the experimental and numerical results of thermal gasification of biomass, on the energy potential of agro-industrial waste from the Portalegre region. Gasification tests were performed in a pilot-scale fluidized bed gasifier, in order to study the behavior of peach stones and miscanthus to investigate the effect of gasification temperatures at 750°C, 800°C and 850°C at a constant biomass flow rate of 45kg/h. In order to optimize the operating conditions of the biomass gasification process, a numerical model is developed namely COMMENT code...
June 21, 2017: Waste Management
https://www.readbyqxmd.com/read/28647218/the-environmental-performance-of-smes-in-the-brazilian-textile-industry-and-the-relationship-with-their-financial-performance
#16
Wagner Cezar Lucato, Elpidio Moreira Costa, Geraldo Cardoso de Oliveira Neto
Currently, the concern with the environment is increasing and organizations seek solutions to preserve nature and at the same time earn higher profits or competitiveness. For this, they make frequent use of structured procedures in order to reduce their costs and expenses. However, it has not been always considered the environmental performance related to the financial performance of these processes. Therefore, this study aimed to investigate the relationship between environmental performance measured by eco-efficiency level with the financial performance of small and medium textile manufacturing companies...
June 21, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28647183/activity-of-tagetes-minuta-linnaeus-asteraceae-essential-oil-against-l3-anisakis-larvae-type-1
#17
Filippo Giarratana, Daniele Muscolino, Graziella Ziino, Alessandro Giuffrida, Stefania Maria Marotta, Vittorio Lo Presti, Vincenzo Chiofalo, Antonio Panebianco
OBJECTIVE: To evaluate in vitro effects of Tagetes minuta L. essential oil (TEO) on L3 Anisakis larvae type 1. METHODS: In order to evaluate the potential use of Tagetes minuta essential oil against L3 Anisakis larvae three different media were tested: 1) a saline solution (SS); 2) an industrial marinating solution (MS); 3) sunflower seeds oil (SO). For each media and concentrations of TEO (0.1%, 0.5%, 1.0% and 5.0% v/v), 20 parasites were introduced into plastic Petri dishes (diameter 90 mm) and maintained at room temperature...
May 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28647152/a-first-report-of-rare-earth-elements-in-northwestern-mediterranean-seaweeds
#18
Stefania Squadrone, Paola Brizio, Marco Battuello, Nicola Nurra, Rocco Mussat Sartor, Alessandro Benedetto, Daniela Pessani, Maria Cesarina Abete
The concentrations of rare earth elements (REE) were determined by ICP-MS in dominant seaweed species, collected from three locations of the northwestern Mediterranean Sea. This is the first study to define levels and patterns of REE in macro algae from these coastal areas. Rare elements are becoming emerging inorganic contaminants in marine ecosystems, due to their worldwide increasing applications in industry, technology, medicine and agriculture. Significant inter-site and interspecies differences were registered, with higher levels of REE in brown and green macro algae than in red seaweeds...
June 21, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28647119/in-vitro-pgpr-properties-and-osmotic-tolerance-of-different-azospirillum-native-strains-and-their-effects-on-growth-of-maize-under-drought-stress
#19
Julia E García, Guillermo Maroniche, Cecilia Creus, Ramón Suárez-Rodríguez, José Augusto Ramirez-Trujillo, María D Groppa
Osmotic variations in the soil can affect bacterial growth diminishing the number of inoculated bacteria. In a scenario of water deficit having tolerant bacteria would be beneficial to achieve a better response of the plant to stress. Thus, selection of more resistant bacteria could be useful to design new inoculants to be used in arid zones. In this sense, a group of Azospirillum isolates deposited in INTA collection was characterized in order to select strains tolerant to osmotic stress. The results obtained demonstrated that Az19 strain has similar in vitro PGPR characteristics to Az39, the most used strain in Argentina for inoculants industries, with the advantage of a better tolerance to osmotic and salt stress...
September 2017: Microbiological Research
https://www.readbyqxmd.com/read/28646886/implementation-science-for-ambulatory-care-safety-a-novel-method-to-develop-context-sensitive-interventions-to-reduce-quality-gaps-in-monitoring-high-risk-patients
#20
Kathryn M McDonald, George Su, Sarah Lisker, Emily S Patterson, Urmimala Sarkar
BACKGROUND: Missed evidence-based monitoring in high-risk conditions (e.g., cancer) leads to delayed diagnosis. Current technological solutions fail to close this safety gap. In response, we aim to demonstrate a novel method to identify common vulnerabilities across clinics and generate attributes for context-flexible population-level monitoring solutions for widespread implementation to improve quality. METHODS: Based on interviews with staff in otolaryngology, pulmonary, urology, breast, and gastroenterology clinics at a large urban publicly funded health system, we applied journey mapping to co-develop a visual representation of how patients are monitored for high-risk conditions...
June 24, 2017: Implementation Science: IS
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