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https://www.readbyqxmd.com/read/28535106/value-tools-in-managed-care-decision-making-current-hurdles-and-future-opportunities
#1
Jeremy Schafer, Dominic Galante, Jason Shafrin
BACKGROUND: Organizations such as the National Comprehensive Cancer Network, American Society of Clinical Oncology, Institute for Clinical and Economic Review, and Memorial Sloan Kettering have created distinct tools to help different stakeholders assess the value of oncology treatments. However, the oncology value tools were not necessarily created for payers, and it is unclear whether payers are using these tools as part of their drug management process. OBJECTIVE: To understand what value tools payers are using in oncology management and what benefits and shortcomings the tools may have from the payer perspective...
June 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28535102/why-value-framework-assessments-arrive-at-different-conclusions-a-multiple-myeloma-case-study
#2
Kimberly Westrich, Lisabeth Buelt, Robert W Dubois
As the United States transitions from a volume-based health care system to one that rewards value, new frameworks are emerging to help patients, providers, and payers assess the value of medical services and biopharmaceutical products. These value assessment frameworks are intended to support various types of health care decision making. They have the potential to substantially affect patients, whether as tools for shared decision making with their doctors, as an input to care pathways used by providers, or through payer use of the frameworks to make coverage or reimbursement decisions...
June 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28532614/evidence-based-medicine-was-bound-to-fail-a-report-to-alvan-feinstein
#3
Giovanni A Fava
John Ioannidis has provided a lucid account, in the form of a report to David Sackett, of how evidence-based medicine (EBM) was hijacked to serve vested interests: major randomized controlled trials are largely done by and for the benefit of the industry; meta-analyses and guidelines are flooded with conflicts of interest; national and federal research funds are unable to address basic clinical questions. Nonetheless, EBM would remain a worthwhile goal. In this paper, in the form of a report to Alvan Feinstein, it is argued that current developments were largely predictable...
April 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28530524/is-real-world-evidence-used-in-p-t-monographs-and-therapeutic-class-reviews
#4
Jason T Hurwitz, Mary Brown, Jennifer S Graff, Loretta Peters, Daniel C Malone
BACKGROUND: Payers are faced with making coverage and reimbursement decisions based on the best available evidence. Often these decisions apply to patient populations, provider networks, and care settings not typically studied in clinical trials. Treatment effectiveness evidence is increasingly available from electronic health records, registries, and administrative claims. However, little is known about when and what types of real-world evidence (RWE) studies inform pharmacy and therapeutic (P&T) committee decisions...
June 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28530031/celecoxib-for-osteoarthritis
#5
REVIEW
Livia Puljak, Ana Marin, Davorka Vrdoljak, Filipa Markotic, Ana Utrobicic, Peter Tugwell
BACKGROUND: Osteoarthritis (OA) is the most common form of arthritis and is caused by degeneration of the joint cartilage and growth of new bone, cartilage and connective tissue. It is often associated with major disability and impaired quality of life. There is currently no consensus on the best treatment to improve OA symptoms. Celecoxib is a selective non-steroidal anti-inflammatory drug (NSAID). OBJECTIVES: To assess the clinical benefits (pain, function, quality of life) and safety (withdrawals due to adverse effects, serious adverse effects, overall discontinuation rates) of celecoxib in osteoarthritis (OA)...
May 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28523612/analysis-of-the-environmental-issues-concerning-the-deployment-of-an-otec-power-plant-in-martinique
#6
Damien A Devault, Anne Péné-Annette
Ocean thermal energy conversion (OTEC) is a form of power generation, which exploits the temperature difference between warm surface seawater and cold deep seawater. Suitable conditions for OTEC occur in deep warm seas, especially the Caribbean, the Red Sea and parts of the Indo-Pacific Ocean. The continuous power provided by this renewable power source makes a useful contribution to a renewable energy mix because of the intermittence of the other major renewable power sources, i.e. solar or wind power. Industrial-scale OTEC power plants have simply not been built...
May 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28490647/placebo-and-nocebo-responses-in-restless-legs-syndrome-a-systematic-review-and-meta-analysis
#7
Maria A Silva, Gonçalo S Duarte, Raquel Camara, Filipe B Rodrigues, Ricardo M Fernandes, Daisy Abreu, Tiago Mestre, João Costa, Claudia Trenkwalder, Joaquim J Ferreira
OBJECTIVE: To estimate the placebo and nocebo responses in restless legs syndrome (RLS) and explore their determinants. METHODS: Databases were searched up to October 2015. Randomized, double-blind, placebo-controlled trials of patients with RLS were included if quantitative data were extractable in the placebo arm. Placebo response was defined as the within-group change from baseline, using any scale measuring RLS severity or disability. Nocebo response was defined as the proportion of patients experiencing adverse events in the placebo arm...
May 10, 2017: Neurology
https://www.readbyqxmd.com/read/28464220/human-factors-effecting-forensic-decision-making-workplace-stress-and-well-being
#8
Amy M Jeanguenat, Itiel E Dror
Over the past decade, there has been a growing openness about the importance of human factors in forensic work. However, most of it focused on cognitive bias, and neglected issues of workplace wellness and stress. Forensic scientists work in a dynamic environment that includes common workplace pressures such as workload volume, tight deadlines, lack of advancement, number of working hours, low salary, technology distractions, and fluctuating priorities. However, in addition, forensic scientists also encounter a number of industry-specific pressures, such as technique criticism, repeated exposure to crime scenes or horrific case details, access to funding, working in an adversarial legal system, and zero tolerance for "errors"...
May 2, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28459045/re-engineering-alzheimer-clinical-trials-global-alzheimer-s-platform-network
#9
J Cummings, P Aisen, R Barton, J Bork, R Doody, J Dwyer, J C Egan, H Feldman, D Lappin, L Truyen, S Salloway, R Sperling, G Vradenburg
Alzheimer's disease (AD) drug development is costly, time-consuming, and inefficient. Trial site functions, trial design, and patient recruitment for trials all require improvement. The Global Alzheimer Platform (GAP) was initiated in response to these challenges. Four GAP work streams evolved in the US to address different trial challenges: 1) registry-to-cohort web-based recruitment; 2) clinical trial site activation and site network construction (GAP-NET); 3) adaptive proof-of-concept clinical trial design; and 4) finance and fund raising...
June 2016: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/28457192/assessment-of-adherence-and-relative-dose-intensity-with-oral-chemotherapy-in-oncology-clinical-trials-at-an-academic-medical-center
#10
Jeff A Engle, Anne M Traynor, Toby C Campbell, Kari B Wisinski, Noelle LoConte, Glenn Liu, George Wilding, Jill M Kolesar
Background/Aims Oral chemotherapy is increasingly utilized leaving the patient responsible for self-administering an often complex regimen where adverse effects are common. Non-adherence and reduced relative dose intensity are both associated with poorer outcomes in the community setting but are rarely reported in clinical trials. The purpose of this study is to quantify adherence and relative dose intensity in oncology clinical trials and to determine patient and study related factors that influence adherence and relative dose intensity...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28456750/accelerating-biomedical-innovation-a-case-study-of-the-spark-program-at-stanford-university-school-of-medicine
#11
REVIEW
Esther Kim, Paige M C Omura, Andrew W Lo
Translating academic medical research into new therapies is an important challenge for the biopharmaceutical industry and investment communities, which have historically favored later-stage assets with lower risk and clearer commercial value. The Stanford SPARK program is an innovative model for addressing this challenge. The program was created in 2006 to educate students and faculty about bringing academic research from bench to bedside. Every year, the program provides mentorship and funding for approximately a dozen SPARK 'scholars', with a focus on impacting patient lives, regardless of economic factors...
April 26, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28453790/does-the-law-on-compensation-for-research-related-injury-in-the-uk-australia-and-new-zealand-meet-ethical-requirements
#12
Joanna M Manning
Despite a consensus that society owes an ethical obligation to compensate for research-related injury, and that no-fault is the best ethical response, an assessment of the compensation arrangements in place in the UK, Australia and New Zealand shows that in general compensation arrangements fall below this ethical expectation. Most subjects rely on ex gratia payment or an unenforceable assurance of payment in the event of injury. It is also likely that, given significant deficiencies in participant information about compensation arrangements in place for trials recommended by the supervisory ethics agencies in each jurisdiction, subjects only find out about their financial exposure in the event of injury...
April 26, 2017: Medical Law Review
https://www.readbyqxmd.com/read/28440929/marine-and-freshwater-microplastic-research-in-south-africa
#13
Carina Verster, Karin Minnaar, Hindrik Bouwman
South Africa has a vibrant plastics manufacturing industry, but recycling is limited and insufficient with a notable proportion of the unmanaged waste entering the environment. South Africa is a developing country with microplastics research in its inception. Very little is known about freshwater microplastics, and studies on South African marine microplastics are limited but actively being pursued. In a water-scarce country, protection of freshwater resources remains a priority, but in the face of other socioeconomic issues (poverty, unemployment, and HIV/AIDS), it receives insufficiently effective attention...
May 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28438271/how-does-an-inventor-find-an-investor-or-partner-raising-funds-to-start-a-company
#14
Rudy A Mazzocchi
Rudy Mazzocchi has over 25 years of senior executive management, technology and intellectual property development, and financing experience in the medical-technology/biotechnology industries. He serves currently as cofounder/chief executive officer of ELENZA, Inc, an ophthalmology company that has developed an electro-active, autofocusing, implantable lens; executive chairman of Establishment Labs; executive chairman of LAFORGE Optical; and executive chairman of OptiSTENT, Inc. He served previously as managing director of Accuitive Medical Ventures and The Innovation Factory; cofounder/chief executive officer of Image-Guided NEUROLOGICS, acquired by Medtronic in 2005; and founding chief executive officer of MICROVENA Corporation, which became "eV3," acquired by Covidien...
May 2017: Surgery
https://www.readbyqxmd.com/read/28433869/community-based-barriers-to-the-wider-acceptance-of-solid-state-nmr
#15
Paul Jonsen
During August 2015, the author surveyed 76 solid state NMR scientists from materials science to biology, academic to industrial, based in North America, Europe, India, China, Japan and Australia. The subject concerned barriers to the wider acceptance of solid state NMR and included the various barriers based on experimental, funding, vendor based and community aspects. This survey was confidential. However, many of the survey participants requested that at least the results of the part of the survey relevant to our community be made public...
February 9, 2017: Solid State Nuclear Magnetic Resonance
https://www.readbyqxmd.com/read/28431347/improving-water-quality-in-china-environmental-investment-pays-dividends
#16
Yongqiang Zhou, Jianrong Ma, Yunlin Zhang, Boqiang Qin, Erik Jeppesen, Kun Shi, Justin D Brookes, Robert G M Spencer, Guangwei Zhu, Guang Gao
This study highlights how Chinese economic development detrimentally impacted water quality in recent decades and how this has been improved by enormous investment in environmental remediation funded by the Chinese government. To our knowledge, this study is the first to describe the variability of surface water quality in inland waters in China, the affecting drivers behind the changes, and how the government-financed conservation actions have impacted water quality. Water quality was found to be poorest in the North and the Northeast China Plain where there is greater coverage of developed land (cities + cropland), a higher gross domestic product (GDP), and higher population density...
July 1, 2017: Water Research
https://www.readbyqxmd.com/read/28430873/bioinformatics-in-germany-toward-a-national-level-infrastructure
#17
Andreas Tauch, Arwa Al-Dilaimi
The German Network for Bioinformatics Infrastructure (de.NBI) is a national initiative funded by the German Federal Ministry of Education and Research (BMBF). The mission of de.NBI is (i) to provide high-quality bioinformatics services to users in basic and applied life sciences research from academia, industry and biomedicine; (ii) to offer bioinformatics training to users in Germany and Europe through a wide range of workshops and courses; and (iii) to foster the cooperation of the German bioinformatics community with international network structures such as the European life-sciences Infrastructure for biological Information (ELIXIR)...
April 18, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28430547/enhancing-insights-into-pulmonary-vascular-disease-pvd-through-a-precision-medicine-approach-a-joint-nhlbi-cmref-workshop-report
#18
John H Newman, Stuart Rich, Steven H Abman, John H Alexander, John Barnard, Gerald J Beck, Raymond L Benza, Todd M Bull, Stephen Y Chan, Hyung J Chun, Declan Doogan, Jocelyn Dupuis, Serpil C Erzurum, Robert P Frantz, Mark Geraci, Hunter Gillies, Mark Gladwin, Michael P Gray, Anna R Hemnes, Roy S Herbst, Adrian F Hernandez, Nicholas S Hill, Evelyn M Horn, Kendall Hunter, Zhi-Cheng Jing, Roger Johns, Sanjay Kaul, Steven M Kawut, Tim Lahm, Jane A Leopold, Greg D Lewis, Stephen C Mathai, Vallerie V McLaughlin, Evangelos D Michelakis, Steven D Nathan, William Nichols, Grier Page, Marlene Rabinovitch, Jonathan Rich, Franz Rischard, Sharon Rounds, Sanjiv J Shah, Victor F Tapson, Naomi Lowy, Norman Stockbridge, Gail Weinmann, Lei Xiao
The Division of Lung Diseases of the National Heart, Lung and Blood Institute, (NHLBI) and the Cardiovascular Medical Education and Research Fund (CMREF), held a workshop to discuss to leverage of the anticipated scientific output from the recently launched "Redefining Pulmonary Hypertension (PH) through Pulmonary Vascular Disease Phenomics" (PVDOMICS) program. PVDOMICS is a protocol driven network to analyze PH patient populations to define novel pulmonary vascular disease (PVD) phenotypes. Basic, translational and clinical investigators, patient advocacy organizations, regulatory agencies, and pharmaceutical industry experts discussed the application of precision medicine to PVD clinical trials...
April 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28428185/investments-in-cancer-research-awarded-to-uk-institutions-and-the-global-burden-of-cancer-2000-2013-a-systematic-analysis
#19
Mahiben Maruthappu, Michael G Head, Charlie D Zhou, Barnabas J Gilbert, Majd A El-Harasis, Rosalind Raine, Joseph R Fitchett, Rifat Atun
OBJECTIVES: To systematically categorise cancer research investment awarded to United Kingdom (UK) institutions in the period 2000-2013 and to estimate research investment relative to disease burden as measured by mortality, disability-adjusted life years (DALYs) and years lived with disability (YLDs). DESIGN: Systematic analysis of all open-access data. SETTING AND PARTICIPANTS: Public and philanthropic funding to all UK cancer research institutions, 2000-2013...
April 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28427366/network-analysis-of-global-tobacco-control-collaboration-data-from-the-world-conference-on-tobacco-or-health-wctoh
#20
Scott J Leischow, Janet Okamoto, Scott McIntosh, Deborah J Ossip, Harry A Lando
BACKGROUND: The World Conference on Tobacco or Health (WCTOH) is held every three years to foster communication and collaboration on global tobacco control. Very little is known about the nature of interactions between WCTOH attendees and their linkages to tobacco control organizations, so knowing this information could help improve tobacco control efforts. METHODS: At the 2015 WCTOH, we implemented an online survey to assess barriers to global tobacco control activities, which information sources they use for tobacco control information, and with whom they interact regarding tobacco control...
April 20, 2017: BMC Public Health
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