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https://www.readbyqxmd.com/read/28213724/mobile-phone-use-and-risk-of-brain-tumours-a-systematic-review-of-association-between-study-quality-source-of-funding-and-research-outcomes
#1
Manya Prasad, Prachi Kathuria, Pallavi Nair, Amit Kumar, Kameshwar Prasad
Mobile phones emit electromagnetic radiations that are classified as possibly carcinogenic to humans. Evidence for increased risk for brain tumours accumulated in parallel by epidemiologic investigations remains controversial. This paper aims to investigate whether methodological quality of studies and source of funding can explain the variation in results. PubMed and Cochrane CENTRAL searches were conducted from 1966 to December 2016, which was supplemented with relevant articles identified in the references...
February 17, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28202934/the-food-industry-and-conflicts-of-interest-in-nutrition-research-a-latin-american-perspective
#2
Joaquin Barnoya, Marion Nestle
Conflicts of interest arise when corporations marketing harmful products establish financial relationships with research institutions, researchers, or public health organizations. As obesity becomes a worldwide epidemic, such relationships threaten to jeopardize the integrity of scientific research. Latin America, a region undergoing rapid development, is particularly vulnerable to such conflicts. Here, we provide examples of how food and beverage companies are funding nutrition-focused research and institutions in Latin America, putting their credibility at risk...
December 2016: Journal of Public Health Policy
https://www.readbyqxmd.com/read/28188606/costs-of-productivity-loss-due-to-occupational-cancer-in-canada-estimation-using-claims-data-from-workers-compensation-boards
#3
W Dominika Wranik, Adam Muir, Min Hu
INTRODUCTION: Cancer is a leading cause of illness globally, yet our understanding of the financial implications of cancer caused by working conditions and environments is limited. The goal of this study is to estimate the costs of productivity losses due to occupational cancer in Canada, and to evaluate the factors associated with these costs. METHODS: Two sources of data are used: (i) Individual level administrative claims data from the Workers Compensation Board of Nova Scotia; and (ii) provincial aggregated cancer claims statistics from the Association of Workers Compensation Boards of Canada...
December 2017: Health Economics Review
https://www.readbyqxmd.com/read/28174182/contribution-of-industry-funded-post-marketing-studies-to-drug-safety-survey-of-notifications-submitted-to-regulatory-agencies
#4
Angela Spelsberg, Christof Prugger, Peter Doshi, Kerstin Ostrowski, Thomas Witte, Dieter Hüsgen, Ulrich Keil
OBJECTIVES:  To investigate the practice of post-marketing studies in Germany during a three year period and to evaluate whether these trials meet the aims specified in the German Medicinal Products Act. DESIGN:  Survey of notifications submitted to German regulatory agencies before post-marketing studies were carried out, 2008-10. SETTING:  Notifications obtained through freedom of information requests to the three authorities responsible for registering post-marketing studies in Germany...
February 7, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28167228/comparison-of-conflict-of-interest-among-published-hernia-researchers-self-reported-to-the-centers-of-medicare-and-medicaid-services-open-payments-database
#5
Oscar A Olavarria, Julie L Holihan, Deepa Cherla, Cristina A Perez, Lillian S Kao, Tien C Ko, Mike K Liang
INTRODUCTION: Many healthcare providers have financial interests and relationships with healthcare companies. In order to maintain transparency, investigators are expected to disclose their conflicts of interest (COI). Recently, the Centers of Medicare and Medicaid Services (CMS) developed an open payment database of COI reported by industry. We hypothesize there is discordance between industry-reported and physician self-reported COI among ventral hernia publications. METHODS: PubMed was searched for ventral hernia studies accepted for publication between June 2013 and October 2015 and published by authors from the United States...
February 3, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28166817/allied-health-research-positions-a-qualitative-evaluation-of-their-impact
#6
Rachel J Wenke, Elizabeth C Ward, Ingrid Hickman, Julie Hulcombe, Rachel Phillips, Sharon Mickan
BACKGROUND: Research positions embedded within healthcare settings have been identified as an enabler to allied health professional (AHP) research capacity; however, there is currently limited research formally evaluating their impact. In 2008, a Health Practitioner industrial agreement funded a research capacity building initiative within Queensland Health, Australia, which included 15 new allied health research positions. The present project used a qualitative and realist approach to explore the impact of these research positions, as well as the mechanisms which facilitated or hindered their success within their respective organisations...
February 6, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28158281/is-investigator-background-related-to-outcome-in-head-to-head-trials-of-psychotherapy-and-pharmacotherapy-for-adult-depression-a-systematic-review-and-meta-analysis
#7
Ioana A Cristea, Claudio Gentili, Pietro Pietrini, Pim Cuijpers
BACKGROUND: The influence of factors related to the background of investigators conducting trials comparing psychotherapy and pharmacotherapy has remained largely unstudied. Specializations emphasizing biological determinants of mental disorders, like psychiatry, might favor pharmacotherapy, while others stressing psychosocial factors, like psychology, could promote psychotherapy. Yet financial conflict of interest (COI) could be a confounding factor as authors with a medical specialization might receive more sponsoring from the pharmaceutical industry...
2017: PloS One
https://www.readbyqxmd.com/read/28157267/myocardial-fibrosis-biomedical-research-from-bench-to-bedside
#8
REVIEW
Mariann Gyöngyösi, Johannes Winkler, Isbaal Ramos, Quoc-Tuan Do, Hüseyin Firat, Kenneth McDonald, Arantxa González, Thomas Thum, Javier Díez, Frédéric Jaisser, Anne Pizard, Faiez Zannad
Myocardial fibrosis refers to a variety of quantitative and qualitative changes in the interstitial myocardial collagen network that occur in response to cardiac ischaemic insults, systemic diseases, drugs, or any other harmful stimulus affecting the circulatory system or the heart itself. Myocardial fibrosis alters the architecture of the myocardium, facilitating the development of cardiac dysfunction, also inducing arrhythmias, influencing the clinical course and outcome of heart failure patients. Focusing on myocardial fibrosis may potentially improve patient care through the targeted diagnosis and treatment of emerging fibrotic pathways...
February 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28152737/financial-risk-sharing-agreements-using-options-to-make-marginal-benefits-cost-effective
#9
(no author information available yet)
: 41 Background: New cancer treatments have become increasingly costly. Although new drugs may be sufficiently cost-efficiency for a primary indication (i1) to receive funding, subsequent indications (ia) may not prove cost-effective. A financial risk-sharing agreement to increase access is proposed. A potential 2012 real-world implementation in Canada for pazopanib use in metastatic renal cell carcinoma (mRCC) as i1, and soft-tissue sarcoma (STS) as ia is presented. METHODS: The market value of an indication can be approximated by its net-present-value (NPV) of expected cash flows...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28131999/cost-effectiveness-research-in-cancer-therapy-a-systematic-review-of-literature-trends-methods-and-the-influence-of-funding
#10
Daoud Al-Badriyeh, Marwah Alameri, Randa Al-Okka
OBJECTIVE: To perform a first-time analysis of the cost-effectiveness (CE) literature on chemotherapies, of all types, in cancer, in terms of trends and change over time, including the influence of industry funding. DESIGN: Systematic review. SETTING: A wide range of cancer-related research settings within healthcare, including health systems, hospitals and medical centres. PARTICIPANTS: All literature comparative CE research of drug-based cancer therapies in the period 1986 to 2015...
January 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28127754/minority-representation-in-migraine-treatment-trials
#11
Nathaniel M Robbins, James L Bernat
BACKGROUND: Minorities have historically been underrepresented in clinical research trials despite having comparatively poor health indicators. Recognizing the dual inequalities of increased disease burden and decreased research participation, the National Institute of Health (NIH) Revitalization Act of 1993 mandated the inclusion and reporting of women and minorities in NIH-funded research. While progress has been made in the subsequent decades, this underrepresentation of minorities in research trials persists and has been documented in multiple disciplines...
January 27, 2017: Headache
https://www.readbyqxmd.com/read/28122623/criteria-to-assess-potential-reverse-innovations-opportunities-for-shared-learning-between-high-and-low-income-countries
#12
Onil Bhattacharyya, Diane Wu, Kathryn Mossman, Leigh Hayden, Pavan Gill, Yu-Ling Cheng, Abdallah Daar, Dilip Soman, Christina Synowiec, Andrea Taylor, Joseph Wong, Max von Zedtwitz, Stanley Zlotkin, William Mitchell, Anita McGahan
BACKGROUND: Low- and middle-income countries (LMICs) are developing novel approaches to healthcare that may be relevant to high-income countries (HICs). These include products, services, organizational processes, or policies that improve access, cost, or efficiency of healthcare. However, given the challenge of replication, it is difficult to identify innovations that could be successfully adapted to high-income settings. We present a set of criteria for evaluating the potential impact of LMIC innovations in HIC settings...
January 25, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28114624/patient-advocacy-organizations-industry-funding-and-conflicts-of-interest
#13
Susannah L Rose, Janelle Highland, Matthew T Karafa, Steven Joffe
Importance: Patient advocacy organizations (PAOs) are influential health care stakeholders that provide direct counseling and education for patients, engage in policy advocacy, and shape research agendas. Many PAOs report having financial relationships with for-profit industry, yet little is known about the nature of these relationships. Objective: To describe the nature of industry funding and partnerships between PAOs and for-profit companies in the United States...
January 17, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28114596/toward-a-healthier-patient-voice-more-independence-less-industry-funding
#14
Ray Moynihan, Lisa Bero
No abstract text is available yet for this article.
January 17, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28107475/review-and-analysis-of-publication-trends-over-three-decades-in-three-high-impact-medicine-journals
#15
Alexander Ivanov, Beata A Kaczkowska, Saadat A Khan, Jean Ho, Morteza Tavakol, Ashok Prasad, Geetha Bhumireddy, Allan F Beall, Igor Klem, Parag Mehta, William M Briggs, Terrence J Sacchi, John F Heitner
CONTEXT: Over the past three decades, industry sponsored research expanded in the United States. Financial incentives can lead to potential conflicts of interest (COI) resulting in underreporting of negative study results. OBJECTIVE: We hypothesized that over the three decades, there would be an increase in: a) reporting of conflict of interest and source of funding; b) percentage of randomized control trials c) number of patients per study and d) industry funding...
2017: PloS One
https://www.readbyqxmd.com/read/28098627/global-collaboration-in-acute-care-clinical-research-opportunities-challenges-and-needs
#16
John C Marshall
The most impactful research in critical care comes from trials groups led by clinician-investigators who study questions arising through the day-to-day care of critically ill patients. The success of this model reflects both "necessity"-the paucity of new therapies introduced through industry-led research-and "clinical reality"-nuanced modulation of standard practice can have substantial impact on clinically important outcomes. Success in a few countries has fueled efforts to build similar models around the world and to collaborate on an unprecedented scale in large international trials...
February 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28097713/pharmacist-industry-relationships
#17
Keene Saavedra, Bonnie O'Connor, Adriane Fugh-Berman
OBJECTIVES: The purpose of this study was to document, in their own words, beliefs and attitudes that American pharmacists have towards the pharmaceutical industry and pharmacists' interactions with industry. METHODS: An ethnographic-style qualitative study was conducted utilizing open-ended interviews with four hospital pharmacists, two independent pharmacists, two retail pharmacists and one administrative pharmacist in the Washington, DC, metropolitan area to elicit descriptions of and attitudes towards pharmacists' relationships with industry...
January 18, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28096109/financial-ties-of-principal-investigators-and-randomized-controlled-trial-outcomes-cross-sectional-study
#18
Rosa Ahn, Alexandra Woodbridge, Ann Abraham, Susan Saba, Deborah Korenstein, Erin Madden, W John Boscardin, Salomeh Keyhani
OBJECTIVE:  To examine the association between the presence of individual principal investigators' financial ties to the manufacturer of the study drug and the trial's outcomes after accounting for source of research funding. DESIGN:  Cross sectional study of randomized controlled trials (RCTs). SETTING:  Studies published in "core clinical" journals, as identified by Medline, between 1 January 2013 and 31 December 2013. PARTICIPANTS:  Random sample of RCTs focused on drug efficacy...
January 17, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28095603/review-of-regulatory-emphasis-on-transportation-safety-in-the-united-states-2002-2009-public-versus-private-modes
#19
Garrett C Waycaster, Taiki Matsumura, Volodymyr Bilotkach, Raphael T Haftka, Nam H Kim
The U.S. Department of Transportation is responsible for implementing new safety improvements and regulations with the goal of ensuring limited funds are distributed to where they can have the greatest impact on safety. In this work, we conduct a study of new regulations and other reactions (such as recalls) to fatal accidents in several different modes of transportation implemented from 2002 to 2009. We find that in the safest modes of commercial aviation and bus transport, the amount of spending on new regulations is high in relation to the number of fatalities compared to the regulatory attention received by less safe modes of general aviation and private automobiles...
January 17, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28092280/challenges-and-opportunities-to-enhance-global-drug-development-in-neonates
#20
Alexandra M Smith, Jonathan M Davis
PURPOSE OF REVIEW: This study reviews the history of neonatal drug development, recent legislative efforts designed to facilitate the study of therapeutic agents in neonates, and future steps necessary to advance drug development. RECENT FINDINGS: Although many federal regulations have been introduced over the past 15 years to encourage pediatric and neonatal drug development, the majority of medications that are used in the Neonatal Intensive Care Unit are not approved by the Food and Drug Administration (FDA) for use in neonates...
January 13, 2017: Current Opinion in Pediatrics
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