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https://www.readbyqxmd.com/read/28319996/oral-direct-acting-agent-therapy-for-hepatitis-c-virus-infection-a-systematic-review
#1
Oluwaseun Falade-Nwulia, Catalina Suarez-Cuervo, David R Nelson, Michael W Fried, Jodi B Segal, Mark S Sulkowski
Background: Rapid improvements in hepatitis C virus (HCV) therapy have led to the approval of multiple oral direct-acting antiviral (DAA) regimens by the U.S. Food and Drug Administration (FDA) for treatment of chronic HCV infection. Purpose: To summarize published literature on the efficacy and safety of oral DAAs for treatment of persons with chronic HCV infection. Data Sources: MEDLINE and EMBASE from inception through 1 November 2016. Study Selection: 42 English-language studies from controlled and single-group registered clinical trials of adults with HCV infection that evaluated at least 8 weeks of an FDA-approved interferon-free HCV regimen that included at least 2 DAAs...
March 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28319783/development-of-an-evaluation-framework-for-publicly-funded-r-d-projects-the-case-of-korea-s-next-generation-network
#2
Eungdo Kim, Soyoung Kim, Hongbum Kim
For decades, efforts have been made globally to measure the performance of large-scale public projects and to develop a framework to perform such measurements due to the complexity and dynamics of R&D and stakeholder interests. Still, limitations such as the use of a simply modified model and the lack of a comprehensive viewpoint are prevalent in existing approaches. In light of these research gaps, this study suggests a practical model to evaluate the performance of large-scale and publicly funded projects...
February 28, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28317821/-long-term-results-of-dental-health-examinations-of-employees-of-industrial-enterprises-with-hazardous-working-conditions
#3
V N Olesova, V V Uiba, T N Novozemtseva, A A Remizova, E E Olesov
The article analyzes the results of dental examination of employees with hazardous and normal working conditions in Atomenergomash enterprise with various dental care organization regimens and provides clear evidence of the effectiveness of serial attendances care in enterprise dental offices in terms of reduction in the dental treatment needs. Additional funding for departmental dental services was calculated by comparing the real cost of dental treatment and MHI tariffs allowing implementation of proposed dental care program...
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28317495/editor-s-corner-does-alcohol-industry-funding-corrupt-alcohol-science-a-startling-revelation-about-the-early-history-of-jsad
#4
Thomas F Babor
No abstract text is available yet for this article.
March 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28293288/techno-economic-analysis-and-climate-change-impacts-of-sugarcane-biorefineries-considering-different-time-horizons
#5
Tassia L Junqueira, Mateus F Chagas, Vera L R Gouveia, Mylene C A F Rezende, Marcos D B Watanabe, Charles D F Jesus, Otavio Cavalett, Artur Y Milanez, Antonio Bonomi
BACKGROUND: Ethanol production from lignocellulosic feedstocks (also known as 2nd generation or 2G ethanol process) presents a great potential for reducing both ethanol production costs and climate change impacts since agricultural residues and dedicated energy crops are used as feedstock. This study aimed at the quantification of the economic and environmental impacts considering the current and future scenarios of sugarcane biorefineries taking into account not only the improvements of the industrial process but also of biomass production systems...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28292744/association-between-trial-registration-and-positive-study-findings-cross-sectional-study-epidemiological-study-of-randomized-trials-esort
#6
Ayodele Odutayo, Connor A Emdin, Allan J Hsiao, Mubeen Shakir, Bethan Copsey, Susan Dutton, Virginia Chiocchia, Michael Schlussel, Peter Dutton, Corran Roberts, Douglas G Altman, Sally Hopewell
Objective To assess whether randomised controlled trials (RCTs) that were registered were less likely to report positive study findings compared with RCTs that were not registered and whether the association varied by funding source.Design Cross sectional study.Study sample All primary RCTs published in December 2012 and indexed in PubMed by November 2013. Trial registration was determined based on the report of a trial registration number in published RCTs or the identification of the trial in a search of trial registries...
March 14, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28290928/indications-of-recruitment-challenges-in-research-with-u-s-military-service-members-a-clinicaltrials-gov-review
#7
Wendy A Cook, Ardith Z Doorenbos
INTRODUCTION: The success of military-relevant health research often depends on recruiting adequate numbers of U.S. military service members as research participants. Researchers have reported difficulties in recruiting service member research participants. Reviews of ClinicalTrials.gov, an online clinical trial registry of publicly and privately sponsored studies, have identified challenges in participant recruitment and barriers to study completion in various research populations. The purpose of this study was to identify indications of difficulty recruiting U...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28283966/data-standardization-and-quality-management
#8
Paul A Lapchak, John H Zhang
Important questions regarding the conduct of scientific research and data transparency have been raised in various scientific forums over the last 10 years. It is becoming clear, that in spite of published RIGOR guidelines, that improvement in the transparency of scientific research is required to focus on the discovery and drug development process so that a treatment can be provided to stroke patients. We have the unique privilege of conducting research using animal models of a disease so that we can address the development of a new therapy, and we should do this with great care and vigilance...
March 10, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28283046/recommendations-from-the-european-working-group-for-value-assessment-and-funding-processes-in-rare-diseases-orph-val
#9
Lieven Annemans, Ségolène Aymé, Yann Le Cam, Karen Facey, Penilla Gunther, Elena Nicod, Michele Reni, Jean-Louis Roux, Michael Schlander, David Taylor, Carlo Tomino, Josep Torrent-Farnell, Sheela Upadhyaya, Adam Hutchings, Lugdivine Le Dez
Rare diseases are an important public health issue with high unmet need. The introduction of the EU Regulation on orphan medicinal products (OMP) has been successful in stimulating investment in the research and development of OMPs. Despite this advancement, patients do not have universal access to these new medicines. There are many factors that affect OMP uptake, but one of the most important is the difficulty of making pricing and reimbursement (P&R) decisions in rare diseases. Until now, there has been little consensus on the most appropriate assessment criteria, perspective or appraisal process...
March 10, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28281500/recent-advances-in-epilepsy-research-in-india
#10
Aparna B Dixit, Jyotirmoy Banerjee, P Sarat Chandra, Manjari Tripathi
There are more than 10 million persons with epilepsy (PWE) in India. Despite availability of antiepileptic drugs (AEDs), there is a large treatment gap varying from 50 to 70% among PWE. For treatable epilepsy, this gap can be attributed to poor education, poverty, cultural beliefs, stigma, and poor healthcare infrastructure; whereas for chronic epilepsy, this gap can be attributed to lack of proper diagnosis and treatment. To prevent, treat, and cure epilepsy, researchers worldwide have made exciting advances across all areas of epilepsy research...
2017: Neurology India
https://www.readbyqxmd.com/read/28281295/management-of-people-with-intermediate-stage-hepatocellular-carcinoma-an-attempted-network-meta-analysis
#11
REVIEW
Davide Roccarina, Avik Majumdar, Douglas Thorburn, Brian R Davidson, Emmanuel Tsochatzis, Kurinchi Selvan Gurusamy
BACKGROUND: There is significant uncertainty in the treatment of intermediate-stage hepatocellular carcinoma which is defined by the Barcelona Clinic Liver Cancer (BCLC) as hepatocellular carcinoma stage B with large, multi-nodular, Child-Pugh status A to B, performance status 0 to 2, and without vascular occlusion or extrahepatic disease. OBJECTIVES: To assess the comparative benefits and harms of different interventions used in the treatment of intermediate-stage hepatocellular carcinoma (BCLC stage B) through a network meta-analysis and to generate rankings of the available interventions according to their safety and efficacy...
March 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28281147/molecular-tumor-boards-ethical-issues-in-the-new-era-of-data-medicine
#12
Henri-Corto Stoeklé, Marie-France Mamzer-Bruneel, Charles-Henry Frouart, Christophe Le Tourneau, Pierre Laurent-Puig, Guillaume Vogt, Christian Hervé
The practice and development of modern medicine requires large amounts of data, particularly in the domain of cancer. The future of personalized medicine lies neither with "genomic medicine" nor with "precision medicine", but with "data medicine" (DM) (big data, data mining). The establishment of this DM has required far-reaching changes, to establish four essential elements connecting patients and doctors: biobanks, databases, bioinformatic platforms and genomic platforms. The "transformation" of scientific research areas, such as genetics, bioinformatics and biostatistics, into clinical specialties has generated a new vision of care...
March 9, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28279128/landscape-of-ms-patient-cohorts-and-registries-recommendations-for-maximizing-impact
#13
Bruce F Bebo, Robert J Fox, Karen Lee, Ursula Utz, Alan J Thompson
BACKGROUND: There is a growing number of cohorts and registries collecting phenotypic and genotypic data from groups of multiple sclerosis patients. Improved awareness and better coordination of these efforts is needed. OBJECTIVE: The purpose of this report is to provide a global landscape of the major longitudinal MS patient data collection efforts and share recommendations for increasing their impact. METHODS: A workshop that included over 50 MS research and clinical experts from both academia and industry was convened to evaluate how current and future MS cohorts could be better used to provide answers to urgent questions about progressive MS...
March 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28275462/highlights-from-the-third-biennial-strategies-for-an-hiv-cure-meeting-14-16-november-2016-bethesda-md-usa
#14
EDITORIAL
Diane Lawrence, Lillian Kuo, Elizabeth Church, Betty Poon, Stephen Smiley, Brigitte Sanders-Beer, Liza Dawson, Karl Salzwedel
Since the first Strategies for an HIV Cure Meeting organised by the National Institute of Allergy and Infectious Diseases (NIAID) in 2012, one of the primary purposes of the meeting has been to facilitate communication and foster collaboration across the NIAID-funded Martin Delaney Collaboratories for HIV cure research (MDC), the broader HIV cure-related research field, and industry and community stakeholders. This year's meeting agenda reflected NIAID's increasing investment over the last 5 years in research to identify strategies for eradicating or achieving long-term remission of HIV infection...
January 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28270487/missed-opportunity-from-randomised-controlled-trials-of-medical-interventions-for-open-angle-glaucoma
#15
Andrew Law, Kristina Lindsley, Benjamin Rouse, Richard Wormald, Kay Dickersin, Tianjing Li
PURPOSE: To evaluate the extent to which intraocular pressure and visual field have been reported as outcomes in randomised controlled trials (also referred to as 'trials') of medical treatments for open-angle glaucoma. METHODS: We identified published reports of trials in a systematic review of medical interventions for open-angle glaucoma our group conducted. We assessed whether intraocular pressure and visual field were reported as trial outcomes and classified them to be either completely or incompletely reported for meta-analysis...
March 7, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28270209/innovative-regenerative-medicines-in-the-eu-a-better-future-in-evidence
#16
EDITORIAL
Mark S Corbett, Andrew Webster, Robert Hawkins, Nerys Woolacott
BACKGROUND: Despite a steady stream of headlines suggesting they will transform the future of healthcare, high-tech regenerative medicines have, to date, been quite inaccessible to patients, with only eight having been granted an EU marketing licence in the last 7 years. Here, we outline some of the historical reasons for this paucity of licensed innovative regenerative medicines. We discuss the challenges to be overcome to expedite the development of this complex and rapidly changing area of medicine, together with possible reasons to be more optimistic for the future...
March 8, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28264940/innovative-environments-in-health-care-where-and-how-new-approaches-to-care-are-succeeding
#17
David W Bates, Aziz Sheikh, David A Asch
Organizations seeking to create innovative environments in health care need to pay attention to a number of factors. These include making available sufficient resources, notably money and physical space, but also coordination and consultation regarding intellectual property and licensing; enabling access to engineers, software developers, and behavioral scientists; making providers and patients available to innovators; having a sufficiently long-term view; and insulating the innovation group from operational demands...
March 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28264805/more-than-80-of-us-patients-groups-take-industry-funds-study-finds
#18
Michael McCarthy
No abstract text is available yet for this article.
March 6, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28261443/how-a-clinical-trial-unit-can-improve-independent-clinical-research-in-rare-tumors-the-italian-sarcoma-group-experience
#19
Emanuela Marchesi, Celeste Cagnazzo, Irene Quattrini, Martina Piccinni Leopardi, Chiara Villa, Giovanni Grignani, Lorenzo D'Ambrosio, Silvia Stacchiotti, Paolo Giovanni Casali, Piero Picci
BACKGROUND: The Italian Sarcoma Group (ISG) is a nonprofit group of professionals established in 1997 aimed to improve the quality of care and promote the independent research in sarcomas. The increased regulatory requirements, the chance to increase the number of trials with other cooperative groups and an interest from pharmaceutical companies in supporting independent research, generated the need of an internal service for research management. METHODS AND RESULTS: In 2010, ISG implemented in its organization a Clinical Trial Unit (CTU)...
2017: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/28253735/antidepressant-efficacy-for-depression-in-children-and-adolescents-industry-and-nimh-funded-studies
#20
John T Walkup
Significant controversy surrounds the efficacy of the newer antidepressants for children and adolescents with depression. The controversy largely hinges on meta-analyses of studies that suggest that antidepressants are minimally effective, not effective, or equivalent to placebo. In this review, the author discusses several scientific and clinical complexities that are important to understand in reviewing the antidepressant literature: the strengths and weaknesses of meta-analyses; the scientific and regulatory context for the large number of antidepressant trials in the late 1990s and early 2000s; and the distinction between a negative trial, where the treatment does not demonstrate efficacy, and a failed trial, where methodological problems make it impossible to draw any conclusion about efficacy...
March 3, 2017: American Journal of Psychiatry
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