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https://www.readbyqxmd.com/read/29351053/patient-variability-seldom-assessed-in-cost-effectiveness-studies
#1
Tara A Lavelle, David M Kent, Christine M Lundquist, Teja Thorat, Joshua T Cohen, John B Wong, Natalia Olchanski, Peter J Neumann
BACKGROUND: Cost-effectiveness analysis (CEA) estimates can vary substantially across patient subgroups when patient characteristics influence preferences, outcome risks, treatment effectiveness, life expectancy, or associated costs. However, no systematic review has reported the frequency of subgroup analysis in CEA, what type of heterogeneity they address, and how often heterogeneity influences whether cost-effectiveness ratios exceed or fall below conventional thresholds. METHODS: We reviewed the CEA literature cataloged in the Tufts Medical Center CEA Registry, a repository describing cost-utility analyses published through 2016...
January 1, 2018: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/29347995/index-of-the-human-papillomavirus-hpv-vaccine-industry-clinical-study-programmes-and-non-industry-funded-studies-a-necessary-basis-to-address-reporting-bias-in-a-systematic-review
#2
Lars Jørgensen, Peter C Gøtzsche, Tom Jefferson
BACKGROUND: Unabridged access to drug industry and regulatory trial registers and data reduces reporting bias in systematic reviews and may provide a complete index of a drug's clinical study programme. Currently, there is no public index of the human papillomavirus (HPV) vaccine industry study programmes or a public index of non-industry funded studies. METHODS: By cross-verification via study programme enquiries to the HPV vaccine manufacturers and regulators and searches of trial registers and journal publication databases, we indexed clinical HPV vaccine studies as a basis to address reporting bias in a systematic review of clinical study reports...
January 18, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29346087/a-not-for-profit-regulatory-model-for-legal-recreational-cannabis-insights-from-the-regulation-of-gaming-machine-gambling-in-new-zealand
#3
Chris Wilkins
A dozen or more regulatory frameworks have been proposed for legal cannabis but many of the "not-for-profit" options have yet to be developed in any detail, reducing the likelihood they will be seriously considered by policy makers. New Zealand's innovative "not-for-profit" regulatory regime for gaming machine gambling (i.e. "slot machines") has reversed the previous increase in gambling expenditure, empowered local councils to cap the number of gambling venues, and is unique in requiring the societies operating gaming machines to distribution 40% of the gross expenditure from machines (i...
January 12, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29334752/the-road-to-registration-aboriginal-and-torres-strait-islander-health-practitioner-training-in-north-queensland
#4
Kristy Hill, Nichole Harvey, Catrina Felton-Busch, Judy Hoskins, Roy Rasalam, Peter Malouf, Sabina Knight
CONTEXT: In 2012, the new profession of Aboriginal and Torres Strait Islander health practitioner (ATSIHP) was registered under the Health Practitioner Regulation National Law Act 2009. The project in this present study evolved out of the Australian Government\'s recognition of the need for the existing Indigenous health worker (IHW) workforce to meet the minimum qualification requirements for registration as ATSIHPs through recognition of prior learning and/or further education. A total of 53 IHWs participated in the upskilling project between June 2014 and June 2015, with approximately 200 IHWs from Queensland expressing an interest in undertaking the training...
January 2018: Rural and Remote Health
https://www.readbyqxmd.com/read/29320973/secular-trends-in-the-impact-factors-of-sle-publications-over-a-45-year-period-a-systematic-review
#5
N Cohen, M Mimouni, M M Glatstein, D E Furst, G Amarilyo
Objective We assessed publication bias in the field of systemic lupus erythematosus (SLE) by conducting a search of randomized, controlled trials (RCTs) on SLE therapies that had been published over the past 45 years. Our aim was to assess a potential publication bias by determining whether RCTs reporting positive results, RCTs with placebo arms, biologics RCTs, and industry-funded RCTs are more likely to be published in journals with higher impact factors (IFs). Methods We conducted a systematic review of all RCTs registered in PubMed between 1 January 1975 and 1 November 2016...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29320606/splitting-water-by-electrochemistry-and-artificial-photosynthesis-excellent-science-but-a-nightmare-of-translation
#6
REVIEW
Markus Antonietti, Alexandr Savateev
Water splitting to its elements, either by electrochemistry or by solar light, is among the most covered areas in nanostructured functional materials. This personal account article analyzes potential downstream translation problems and reviews alternative chemistries with a potential higher return. Liberation of oxygen for accepting the holes is a kinetically demanding half reaction afflicted with kinetic hindrances and high overpotentials, while at the same time no marketable value is created (atmospheric oxygen is free to use)...
January 10, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29319573/identifying-sources-of-funding-that-contribute-to-scholastic-productivity-in-academic-plastic-surgeons
#7
Qing Zhao Ruan, Justin B Cohen, Yoonji Baek, Austin D Chen, Andres F Doval, Dhruv Singhal, Eugene Y Fukudome, Samuel J Lin, Bernard T Lee
BACKGROUND: Scholastic productivity has previously been shown to be positively associated with National Institute of Health (NIH) grants and industry funding. This study examines whether society, industry, or federal funding contributes toward academic productivity as measured by scholastic output of academic plastic surgeons. METHODS: Institution Web sites were used to acquire academic attributes of full-time academic plastic surgeons. The Center for Medicare and Medicaid Services Open Payment database, NIH reporter, the Plastic Surgery Foundation (PSF), and American Association of Plastic Surgeons (AAPS) Web sites were accessed for funding and endowment details...
January 9, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29307057/comparison-of-hernia-registries-the-core-project
#8
REVIEW
I Kyle-Leinhase, F Köckerling, L N Jørgensen, A Montgomery, J F Gillion, J A P Rodriguez, W Hope, F Muysoms
INTRODUCTION: The aim of the international CORE project was to explore the databases of the existing hernia registries and compare them in content and outcome variables. METHODS: The CORE project was initiated with representatives from all established hernia registries (Danish Hernia Database, Swedish Hernia Registry, Herniamed, EuraHS, Club Hernie, EVEREG, AHSQC) in March 2015 in Berlin. The following categories were used to compare the registries: initiation and funding, data collection and use for certification of hernia centers, patient data and data protection, operative data, registration of complications and follow-up data...
January 6, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29302174/neglected-population-neglected-right-children-living-with-hiv-and-the-right-to-science
#9
Michael L Scanlon, Gillian MacNaughton, Courtenay Sprague
The laws, language, and tools of human rights have been instrumental in expanding access to lifesaving treatment for people living with HIV. Children, however, remain a neglected population, as evidenced by inadequate child-specific and child-friendly HIV treatment options. In this article, we explore the right to science, a potentially powerful but underdeveloped right in international law, and its application to research and development for pediatric HIV treatment. Drawing on reports of human rights bodies and scholars and applying the human rights typology of state obligations to respect, protect, and fulfill, we argue that states have five core obligations related to research and development for child-specific and child-friendly treatment: (1) adopting a public goods approach to science and science policy; (2) including and protecting children in research activities; (3) adopting legal and policy frameworks to support research and development through public funding and private sector incentives; (4) promoting international cooperation and assistance; and (5) ensuring the participation of marginalized communities in decision-making processes...
December 2017: Health and Human Rights
https://www.readbyqxmd.com/read/29282031/competing-with-big-business-a-randomised-experiment-testing-the-effects-of-messages-to-promote-alcohol-and-sugary-drink-control-policy
#10
Maree Scully, Emily Brennan, Sarah Durkin, Helen Dixon, Melanie Wakefield, Colleen L Barry, Jeff Niederdeppe
BACKGROUND: Evidence-based policies encouraging healthy behaviours are often strongly opposed by well-funded industry groups. As public support is crucial for policy change, public health advocates need to be equipped with strategies to offset the impact of anti-policy messages. In this study, we aimed to investigate the effectiveness of theory-based public health advocacy messages in generating public support for sugary drink/alcohol policies (increased taxes; sport sponsorship bans) and improving resistance to subsequent anti-policy messages typical of the sugary drink/alcohol industry...
December 28, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29274580/management-strategies-for-trace-organic-chemicals-in-water-a-review-of-international-approaches
#11
REVIEW
Stefan Bieber, Shane A Snyder, Sonia Dagnino, Tanja Rauch-Williams, Jörg E Drewes
To ensure an appropriate management of potential health risks and uncertainties from the release of trace organic chemicals (TOrCs) into the aqueous environment, many countries have evaluated and implemented strategies to manage TOrCs. The aim of this study was to evaluate existing management strategies for TOrCs in different countries to derive and compare underlying core principles and paradigms and to develop suggestions for more holistic management strategies to protect the environment and drinking water supplies from the discharge of undesired TOrCs...
December 16, 2017: Chemosphere
https://www.readbyqxmd.com/read/29273664/postmarketing-studies-for-novel-drugs-approved-by-both-the-fda-and-ema-between-2005-and-2010-a-cross-sectional-study
#12
Jean-David Zeitoun, Joseph S Ross, Ignacio Atal, Alexandre Vivot, Nicholas S Downing, Gabriel Baron, Philippe Ravaud
OBJECTIVES: To characterise postmarketing studies for drugs that were newly approved by the US Food and Drug Administration and the European Medicines Agency. DESIGN AND SETTING: Cross-sectional analysis of postmarketing studies registered in ClinicalTrials.gov until September 2014 for all novel drugs approved by both regulators between 2005 and 2010. Regulatory documents from both agencies were used. PRIMARY AND SECONDARY OUTCOME MEASURES: All identified postmarketing studies were classified according to planned enrolment, funding, status and geographical location, and we determined whether studies studied the originally approved indication...
December 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/29240976/clopidogrel-plus-aspirin-versus-aspirin-alone-for-preventing-cardiovascular-events
#13
REVIEW
Alessandro Squizzato, Marta Bellesini, Andrea Takeda, Saskia Middeldorp, Marco Paolo Donadini
BACKGROUND: Aspirin is the prophylactic antiplatelet drug of choice for people with cardiovascular disease. Adding a second antiplatelet drug to aspirin may produce additional benefit for people at high risk and people with established cardiovascular disease. This is an update to a previously published review from 2011. OBJECTIVES: To review the benefit and harm of adding clopidogrel to aspirin therapy for preventing cardiovascular events in people who have coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease, or were at high risk of atherothrombotic disease, but did not have a coronary stent...
December 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29237159/sugar-sweetened-beverages-and-weight-gain-in-children-and-adults-a-systematic-review-from-2013-to-2015-and-a-comparison-with-previous-studies
#14
Maria Luger, Max Lafontan, Maira Bes-Rastrollo, Eva Winzer, Volkan Yumuk, Nathalie Farpour-Lambert
OBJECTIVE: Partly inconsistent findings from previous reviews have fueled discussions on the impact of sugar-sweetened beverages (SSBs) on obesity development. The aim was to systematically review the recent evidence in children and adults. METHODS: Data were retrieved from the databases MEDLINE, EMBASE, and Cochrane library for the period January 2013 to October 2015. A systematic review of prospective cohort studies and randomized controlled trials (RCTs) relating SSBs to weight measures was conducted...
December 14, 2017: Obesity Facts
https://www.readbyqxmd.com/read/29237007/a-nationwide-serosurvey-of-hepatitis-e-virus-antibodies-in-the-general-population-of-portugal
#15
Maria S J Nascimento, Sara S Pereira, Joana Teixeira, Joana Abreu-Silva, Ricardo M S Oliveira, Mette Myrmel, Kathrine Stene-Johansen, Joakim Øverbø, Guilherme Gonçalves, João R Mesquita
Background: Evidence has shown that Hepatitis E virus (HEV) genotype 3 is autochthonous in industrialized countries due to zoonotic transmission through direct contact or consumption of raw or undercooked meat from domestic swine or wild boar. As there is lack of data on seroprevalence of HEV in the general Portuguese population, a wide survey was conducted as part of the HEPeCONTROL project (60DT2), under EEA grants funding. Methods: Sera from a representative sample of the Portuguese population (n = 1656) at different geographic locations (30 territorial units), and age (0-99 years) were collected between July 2015 and February 2016...
December 11, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29234946/comparison-of-published-and-unpublished-phase-i-clinical-cancer-trials-an-analysis-of-the-clinicltrials-gov-database
#16
REVIEW
D Shepshelovich, H Goldvaser, L Wang, A R Abdul Razak
Introduction The role of phase I cancer trials is constantly evolving and they are increasingly being used in 'go/no' decisions in drug development. As a result, there is a growing need to ensure trials are published when completed. There are limited data on the publication rate and the factors associated with publication in phase I trials. Methods The ClinicalTrials.gov database was searched for completed adult phase I cancer trials with reported results. PubMed was searched for matching publications published prior to April 1, 2017...
December 13, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/29233263/discovery-of-pet-radiopharmaceuticals-at-the-academia-industry-interface
#17
REVIEW
Vadim Bernard-Gauthier, Thomas L Collier, Steven H Liang, Neil Vasdev
Project-specific collaborations between academia and pharmaceutical partners are a growing phenomenon within molecular imaging and in particular in the positron emission tomography (PET) radiopharmaceutical community. This cultural shift can be attributed in part to decreased public funding in academia in conjunction with the increased reliance on outsourcing of chemistry, radiochemistry, pharmacology and molecular imaging studies by the pharmaceutical industry. This account highlights some of our personal experiences working with industrial partners to develop new PET radiochemistry methodologies for drug discovery and neuro-PET research studies...
November 2017: Drug Discovery Today. Technologies
https://www.readbyqxmd.com/read/29226307/macrolides-for-treatment-of-haemophilus-ducreyi-infection-in-sexually-active-adults
#18
REVIEW
Laura Romero, Cesar Huerfano, Carlos F Grillo-Ardila
BACKGROUND: Chancroid is a genital ulcerative disease caused by Haemophilus ducreyi. This microorganism is endemic in Africa, where it can cause up to 10% of genital ulcers. Macrolides may be an effective alternative to treat chancroid and, based on their oral administration and duration of therapy, could be considered as first line therapy. OBJECTIVES: To assess the effectiveness and safety of macrolides for treatment of H ducreyi infection in sexually active adults...
December 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29221869/characteristics-of-hospitalizations-due-to-acute-stroke-in-the-silesian-province-poland-between-2009-and-2015
#19
Anna Starostka-Tatar, Beata Łabuz-Roszak, Michał Skrzypek, Anetta Lasek-Bal, Mariusz Gąsior, Marek Gierlotka
INTRODUCTION: The available data on acute stroke (AS) in Poland come mainly from non-representative cohorts or are outdated. Therefore, the current study was done to access the most recent data on AS in the industrial region that covers 12% (4.6mln) of the country's population. OBJECTIVE: To evaluate the epidemiological data of AS in the Silesian Province, Poland. PATIENTS AND METHODS: Analysis of the data from stroke questionnaires, obligatory for all patients hospitalized due to AS and administered by the only public health insurer in Poland (the National Health Fund) between 2009 and 2015 (n=81,193)...
November 27, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29218886/clingen-cancer-somatic-working-group-standardizing-and-democratizing-access-to-cancer-molecular-diagnostic-data-to-drive-translational-research
#20
Subha Madhavan, Deborah Ritter, Christine Micheel, Shruti Rao, Angshumoy Roy, Dmitriy Sonkin, Matthew Mccoy, Malachi Griffith, Obi L Griffith, Peter Mcgarvey, Shashikant Kulkarni
A growing number of academic and community clinics are conducting genomic testing to inform treatment decisions for cancer patients (1). In the last 3-5 years, there has been a rapid increase in clinical use of next generation sequencing (NGS) based cancer molecular diagnostic (MolDx) testing (2). The increasing availability and decreasing cost of tumor genomic profiling means that physicians can now make treatment decisions armed with patient-specific genetic information. Accumulating research in the cancer biology field indicates that there is significant potential to improve cancer patient outcomes by effectively leveraging this rich source of genomic data in treatment planning (3)...
2018: Pacific Symposium on Biocomputing
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