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https://www.readbyqxmd.com/read/29050324/prognostic-and-predictive-value-of-metastatic-lymph-node-ratio-in-stage-iii-gastric-cancer-after-d2-nodal-dissection
#1
Yinbo Chen, Cong Li, Yian Du, Qi Xu, Jieer Ying, Cong Luo
INTRODUCTION: This study is to evaluate the prognostic and predictive value of metastatic lymph node ratio (MLR) in stage III gastric cancer following radical D2 dissection. METHODS: 87 patients who underwent radical resection with D2 lymphadenectomy were retrospectively evaluated. The median age was 60 with a 2:1 ratio of male/female. Of these 87 patients, 83 underwent total gastrectomy, the remaining 4 underwent subtotal gastrectomy and 57 patients received adjuvant chemotherapy with fluoropyrimidines...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049841/predictive-value-of-the-8th-edition-american-joint-commission-cancer-ajcc-nodal-staging-system-for-patients-with-cutaneous-squamous-cell-carcinoma-of-the-head-and-neck
#2
Jessica Liu, Ardalan Ebrahimi, Tsu-Hui Hubert Low, Kan Gao, Carsten E Palme, Ch'ng Sydney, Bruce G Ashford, N Gopalakrishna Iyer, Jonathan R Clark, Ruta Gupta
BACKGROUND: The 8th edition American Joint Committee on Cancer (AJCC8) provides the same nodal staging system for mucosal and cutaneous squamous cell carcinoma of the head and neck (HNcSCC) and includes extranodal extension (ENE) as an adverse prognostic criterion. This study evaluates the prognostic efficacy of the AJCC8 pathologic nodal staging system (pN) for HNcSCC. METHODS: Univariate analysis of 382 patients with metastatic HNcSCC staged according to both the 7th (AJCC7) and the 8th edition staging systems...
October 19, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29049744/extended-pleurectomy-decortication-for-malignant-pleural-mesothelioma-in-the-elderly-the-need-for-an-inclusive-yet-selective-approach
#3
Annabel Jane Sharkey, Rocco Bilancia, Sara Tenconi, Apostolos Nakas, David A Waller
OBJECTIVES: The median age at diagnosis of patients with pleural mesothelioma in the UK is 73 years. Recent series have shown the feasibility of extended pleurectomy decortication in the elderly, but with continuing debate about the efficacy of this treatment, we reviewed our experience to identify more detailed selection criteria. METHODS: We reviewed prospectively collected data on all patients from 1999 to 2016 undergoing extended pleurectomy decortication...
July 21, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29045536/the-warburg-effect-persistence-of-stem-cell-metabolism-in-cancers-as-a-failure-of-differentiation
#4
M Riester, Q Xu, A Moreira, J Zheng, F Michor, R J Downey
BACKGROUND: Two recent observations regarding the Warburg effect are that (i) the metabolism of stem cells is constitutive ('aerobic') glycolysis while normal cellular differentiation involves a transition to oxidative phosphorylation and (ii) the degree of glucose uptake of a malignancy as imaged by 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is associated with histologic measures of tumor differentiation. Combining these observations, we hypothesized that the high levels of glucose uptake observed in poorly differentiated cancers may reflect persistence of the glycolytic metabolism of stem cells in malignant cells that fail to fully differentiate...
October 13, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29045517/clinicobiological-features-and-prognostic-impact-of-diffuse-large-b-cell-lymphoma-component-in-the-outcome-of-patients-with-previously-untreated-follicular-lymphoma
#5
L Magnano, O Balagué, I Dlouhy, J Rovira, K Karube, M Pinyol, A Rivas-Delgado, D Costa, A Martínez-Trillos, B González-Farre, A Martínez-Pozo, E Giné, D Colomer, J Delgado, N Villamor, E Campo, A López-Guillermo
Background: The co-existence at diagnosis of follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) components (FL/DLBCL) has been considered a transformed lymphoma and accordingly treated although clinicobiological information on these patients is scarce. The aim of this study was to analyze the initial features and outcome of FL/DLBCL patients in the rituximab era. Patients and methods: All patients consecutively diagnosed at a single institution with FL/DLBCL (n = 40), as well as those with pure FL (n = 328) or de novo DLBCL (n = 510) as controls...
August 2, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29044787/intracardiac-ablation-for-atrioventricular-nodal-reentry-tachycardia-using-a-6%C3%A2-mm-distal-electrode-cryoablation-catheter-prospective-multicenter-north-american-study-icy-avnrt-study
#6
Peter Wells, Marc Dubuc, George J Klein, Dan Dan, Jean-Francois Roux, Evan Lockwood, Marcio Sturmer, David Dunbar, Paul Novak, Arun Rao, Brett J Peterson, Fred Kueffer, Kenneth A Ellenbogen
INTRODUCTION: Radiofrequency (RF) ablation is effective for slow pathway ablation, but carries a risk of inadvertent AV block requiring permanent pacing. By comparison, cryoablation with a 4 mm distal electrode catheter has not been reported to cause permanent AV block but has been shown to be less effective than RF ablation. We sought to define the safety and efficacy of a 6 mm distal electrode cryoablation catheter for slow pathway ablation in patients with atrioventricular nodal reentry tachycardia (AVNRT)...
October 17, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29044100/experimental-realization-of-two-dimensional-dirac-nodal-line-fermions-in-monolayer-cu2si
#7
Baojie Feng, Botao Fu, Shusuke Kasamatsu, Suguru Ito, Peng Cheng, Cheng-Cheng Liu, Ya Feng, Shilong Wu, Sanjoy K Mahatha, Polina Sheverdyaeva, Paolo Moras, Masashi Arita, Osamu Sugino, Tai-Chang Chiang, Kenya Shimada, Koji Miyamoto, Taichi Okuda, Kehui Wu, Lan Chen, Yugui Yao, Iwao Matsuda
Topological nodal line semimetals, a novel quantum state of materials, possess topologically nontrivial valence and conduction bands that touch at a line near the Fermi level. The exotic band structure can lead to various novel properties, such as long-range Coulomb interaction and flat Landau levels. Recently, topological nodal lines have been observed in several bulk materials, such as PtSn4, ZrSiS, TlTaSe2 and PbTaSe2. However, in two-dimensional materials, experimental research on nodal line fermions is still lacking...
October 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/29044057/clinicodemographic-profile-and-treatment-outcome-in-patients-of-ocular-surface-squamous-neoplasia
#8
Rachna Meel, Rebika Dhiman, Murugesan Vanathi, Neelam Pushker, Radhika Tandon, Saranya Devi
PURPOSE: The aim is to study the clinicodemographic profile and treatment outcome of ocular surface squamous neoplasia (OSSN). METHODS: This was a retrospective observational study of 57 eyes (56 cases) with clinically diagnosed OSSN, presenting in our center over the past year. RESULTS: The median age of presentation was 55 years with male:female ratio being 4.5:1. Systemic predisposing conditions were xeroderma pigmentosa (1) postkidney transplant immunosuppression (1), and human immunodeficiency virus infection (1)...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29044024/-induction-of-atrioventricular-nodal-reentrant-tachycardia-by-radiofrequency-application
#9
Oscar A Pellizzón, Sebastián Nannini
Atrioventricular nodal reentrant tachycardia is the most common form of sustained regular narrow QRS complex tachycardia. It is caused by the presence of a dual atrioventricular nodal anatomy and physiology, with a fast and a slow pathway forming a substrate for re-entry. Electrophysiology study confirms the diagnosis when the tachycardia is induced, although in some cases this is not possible. Casuistry is here presented where the application of radiofrequency induced atrioventricular nodal reentrant tachycardia, when the electrophysiological study could not do it; we explain here its electrophysiological mechanism...
2017: Medicina
https://www.readbyqxmd.com/read/29043580/a-comprehensive-assessment-of-accurate-lymph-node-staging-and-preoperative-detection-in-resected-pancreatic-cancer
#10
Toshiro Masuda, Amanda M Dann, Irmina A Elliott, Hideo Baba, Stephen Kim, Alireza Sedarat, V Raman Muthusamy, Mark D Girgis, O Joe Hines, Howard A Reber, Timothy R Donahue
BACKGROUND: The current (seventh edition) American Joint Commission on Cancer (AJCC) Staging System for pancreatic ductal adenocarcinoma (PDAC) dichotomizes pathologic lymph node (LN) involvement into absence (pN0) or presence (pN1) of disease. The recently announced eighth edition also includes stratification on the number of positive nodes. Furthermore, LNs detected on preoperative imaging (CT, MRI, or endoscopic ultrasound-EUS) are considered to be pathologically involved in other gastrointestinal cancers...
October 17, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29043428/magnetic-resonance-imaging-for-clinical-management-of-rectal-cancer-updated-recommendations-from-the-2016-european-society-of-gastrointestinal-and-abdominal-radiology-esgar-consensus-meeting
#11
Regina G H Beets-Tan, Doenja M J Lambregts, Monique Maas, Shandra Bipat, Brunella Barbaro, Luís Curvo-Semedo, Helen M Fenlon, Marc J Gollub, Sofia Gourtsoyianni, Steve Halligan, Christine Hoeffel, Seung Ho Kim, Andrea Laghi, Andrea Maier, Søren R Rafaelsen, Jaap Stoker, Stuart A Taylor, Michael R Torkzad, Lennart Blomqvist
OBJECTIVES: To update the 2012 ESGAR consensus guidelines on the acquisition, interpretation and reporting of magnetic resonance imaging (MRI) for clinical staging and restaging of rectal cancer. METHODS: Fourteen abdominal imaging experts from the European Society of Gastrointestinal and Abdominal Radiology (ESGAR) participated in a consensus meeting, organised according to an adaptation of the RAND-UCLA Appropriateness Method. Two independent (non-voting) Chairs facilitated the meeting...
October 17, 2017: European Radiology
https://www.readbyqxmd.com/read/29043235/platelet-to-lymphocyte-ratio-plr-retains-independent-prognostic-significance-in-advanced-stage-marginal-zone-lymphoma-patients-treated-with-rituximab-cyclophosphamide-vincristine-and-prednisone-combination-chemotherapy-r-cvp-consortium-for-improving-survival
#12
Jeongkuk Seo, Won Seog Kim, Jin Seok Kim, Seok Jin Kim, Jae Hoon Lee, Jun Shik Hong, Gyeong-Won Lee, Sung Yong Oh, Ji-Hyun Lee, Dok Hyun Yoon, Won-Sik Lee, Hyo Jung Kim, Jae-Yong Kwak, Hye Jin Kang, Jae-Cheol Jo, Yong Park, Ho Sup Lee, Hyo-Jin Kim, Cheolwon Suh
BACKGROUND: Rituximab plus cyclophosphamide, vincristine, and prednisone (R-CVP) is one of the effective chemotherapeutic regimens for patients with advanced stage marginal zone lymphoma (MZL). However, prognostic factors that affect the outcome of treatment for MZL are not well understood. METHODS: Between August 2006 and June 2013, patients with newly diagnosed stage III and IV MZL treated with R-CVP as a first-line therapy from 15 institutions were retrospectively analyzed...
September 2017: Blood Research
https://www.readbyqxmd.com/read/29043207/mantle-cell-lymphoma-involvement-of-nodal-and-extranodal-sites-in-the-head-and-neck-with-multifocal-oral-lesions
#13
Marcelo Marcucci, Gilberto Marcucci, Mirna Scalon Cordeiro, Jorge Esquiche León, Juliane Piragine Araujo, Jefferson Xavier de Oliveira, Karina Cecília Panelli Santos
Mantle cell lymphoma (MCL) is a malignant B-cell neoplasm, which comprises monomorphic and small- to medium-sized mantle zone-derived lymphoid cells. It is characterized by chromosomal translocation t(11;14)(q13;q32) and CCND1 truncation, resulting in cell cycle deregulation. It is an aggressive type of non-Hodgkin lymphoma with a propensity to present with extranodal involvement. This study shows the case of an 80-year-old Caucasian male who complained of a 2-month progressive swelling on the right side of his face...
July 2017: Autopsy & case reports
https://www.readbyqxmd.com/read/29043148/membranoproliferative-glomerulonephritis-associated-with-rosai-dorfman-disease
#14
Keisuke Sugimoto, Satoshi Ueda, Mitsuru Okada, Tsukasa Takemura
Rosai-Dorfman disease is also known as sinus histiocytosis with massive lymphadenopathy. Extranodal Rosai-Dorfman disease has been reported in ~ 43% of cases; the most frequent extranodal sites - skin, soft tissue, bone, respiratory tract, and eye - are usually involved in association with lymphadenopathy. Lack of lymph node involvement is rare, especially when patients manifest renal disease. Here, we describe a patient who developed membranoproliferative glomerulonephritis when lymphadenopathy was absent...
2017: Clin Nephrol Case Stud
https://www.readbyqxmd.com/read/29042948/the-efficacy-of-radiofrequency-ablation-in-the-treatment-of-pediatric-arrhythmia-and-its-effects-on-serum-il-6-and-hs-crp
#15
Chunli Li, Libo Jia, Zhenzhou Wang, Ling Niu, Xinjiang An
The aim of this study was to investigate the efficacy of radiofrequency ablation in the treatment of pediatric arrhythmia and to assess the changes in serum interleukin-6 (IL-6) and hs-CRP levels after treatment. Hundred and six children with tachyarrhythmia who were admitted to Xuzhou Children's Hospital from November, 2014 to December, 2015 were recruited for study. The efficacies of radiofrequency in the treatment of different types of arrhythmia were analyzed. Successful ablation was found in 104 cases (98...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042174/results-of-upfront-therapy-for-marginal-zone-lymphoma
#16
José L Ortega, Fernando Cabanillas, Noridza Rivera, Maribel Tirado-Gomez, Deana Hallman, Wandaly I Pardo, Margarita Bruno
BACKGROUND: Marginal zone lymphomas (MZLs) are indolent disorders composed of 3 subtypes: extranodal marginal zone lymphoma (MALT), splenic marginal zone lymphoma (SMZL), and nodal marginal zone lymphoma (NMZL). Early-stage MALT is treated with radiotherapy or antibiotics, and advanced MALT and NMZL are managed with either watch and wait or chemotherapy. SMZLs are treated with splenectomy or rituximab. However, because these approaches have failed to cure patients with SMZL and NMZL, we have systematically used upfront chemotherapy for them, as well as for advanced MALT...
September 23, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29042050/scoring-system-to-predict-nodal-metastases-in-patients-with-early-stage-esophageal-cancer-an-outstanding-tool-to-complement-multidisciplinary-team-based-care
#17
EDITORIAL
Mara B Antonoff
No abstract text is available yet for this article.
November 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29038243/an-%C3%AE-ii-spectrin-based-cytoskeleton-protects-large-diameter-myelinated-axons-from-degeneration
#18
Claire Yu-Mei Huang, Chuansheng Zhang, Daniel R Zollinger, Christophe Leterrier, Matthew N Rasband
Axons must withstand mechanical forces including tension, torsion, and compression. Spectrins and actin form a periodic cytoskeleton proposed to protect axons against these forces. However, since spectrins also participate in assembly of axon initial segments (AIS) and nodes of Ranvier, it is difficult to uncouple their roles in maintaining axon integrity from their functions at AIS and nodes. To overcome this problem and to determine the importance of spectrin cytoskeletons for axon integrity, we generated mice with αII spectrin-deficient peripheral sensory neurons...
October 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29037598/hierarchical-subcortical-sub-regional-shape-network-analysis-in-alzheimer-s-disease
#19
Jingyuan Li, Yujing Gong, Xiaoying Tang
In this paper, by utilizing surface diffeomorphic deformations, we constructed and analyzed subcortical shape morphometric networks in 210 healthy control (HC) subjects and 175 subjects with Alzheimer's disease (AD), aiming to identify AD-induced abnormalities in the subcortical shape network. We quantitatively analyzed pertinent network attributes of the entire network and each node. Further to this, hierarchical analyses were performed; group comparisons were conducted at the structure level first and then the sub-region level...
October 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/29037217/subtype-specific-differentiation-of-cardiac-pacemaker-cell-clusters-from-human-induced-pluripotent-stem-cells
#20
Patrick A Schweizer, Fabrice F Darche, Nina D Ullrich, Pascal Geschwill, Boris Greber, Rasmus Rivinius, Claudia Seyler, Karin Müller-Decker, Andreas Draguhn, Jochen Utikal, Michael Koenen, Hugo A Katus, Dierk Thomas
BACKGROUND: Human induced pluripotent stem cells (hiPSC) harbor the potential to differentiate into diverse cardiac cell types. Previous experimental efforts were primarily directed at the generation of hiPSC-derived cells with ventricular cardiomyocyte characteristics. Aiming at a straightforward approach for pacemaker cell modeling and replacement, we sought to selectively differentiate cells with nodal-type properties. METHODS: hiPSC were differentiated into spontaneously beating clusters by co-culturing with visceral endoderm-like cells in a serum-free medium...
October 16, 2017: Stem Cell Research & Therapy
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