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https://www.readbyqxmd.com/read/29677630/resting-heart-rate-and-the-incidence-and-progression-of-valvular-calcium-the-multi-ethnic-study-of-atherosclerosis-mesa
#1
Kojo Amoakwa, Oluwaseun E Fashanu, Martin Tibuakuu, Di Zhao, Eliseo Guallar, Seamus P Whelton, Wesley T O'Neal, Wendy S Post, Matthew J Budoff, Erin D Michos
BACKGROUND AND AIMS: Left-sided valvular calcification is associated with cardiovascular disease (CVD) morbidity and mortality. Resting heart rate (RHR) may influence valvular calcium progression through shear stress. Whether RHR, an established CVD risk factor, is associated with valvular calcium progression is unknown. We assessed whether RHR predicts incidence and progression of mitral annular calcium (MAC) and aortic valve calcium (AVC) in a community-based cohort free of CVD at baseline...
April 6, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29675646/validation-of-the-8th-edition-of-the-ajcc-uicc-tnm-staging-system-for-tongue-squamous-cell-carcinoma
#2
Satoshi Kano, Tomohiro Sakashita, Nayuta Tsushima, Takatsugu Mizumachi, Akira Nakazono, Takayoshi Suzuki, Shinichiro Yasukawa, Akihiro Homma
BACKGROUND: The revised 8th edition of the AJCC/UICC staging system was released in January 2017, and depth of invasion (DOI) was added to the new criteria for T classification in oral cavity cancer. In this study, we evaluated whether the 8th edition presents the prognosis and risk of nodal metastasis in patients with squamous cell carcinoma of tongue more accurately than did the 7th edition. METHODS: The data for 112 patients were obtained and reclassified based on the criteria presented in the 8th edition...
April 19, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29674334/p-wave-amplitude-and-pr-changes-in-patients-with-inappropriate-sinus-tachycardia-findings-supportive-of-a-central-mechanism
#3
Michael E Field, Paolo Donateo, Nicola Bottoni, Matteo Iori, Michele Brignole, Ryan T Kipp, Douglas E Kopp, Miguel A Leal, Lee L Eckhardt, Jennifer M Wright, Kathleen E Walsh, Richard L Page, Mohamed H Hamdan
BACKGROUND: The mechanism of inappropriate sinus tachycardia (IST) remains incompletely understood. METHODS AND RESULTS: We prospectively compared 3 patient groups: 11 patients with IST (IST Group), 9 control patients administered isoproterenol (Isuprel Group), and 15 patients with cristae terminalis atrial tachycardia (AT Group). P-wave amplitude in lead II and PR interval were measured at a lower and higher heart rate (HR1 and HR2, respectively). P-wave amplitude increased significantly with the increase in HR in the IST Group (0...
April 19, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29673774/clinical-features-and-prognosis-of-asian-patients-with-acral-lentiginous-melanoma-who-have-nodal-nevi-in-their-sentinel-lymph-node-biopsy-specimen
#4
Ho-Jin Kim, Jeong-Wan Seo, Mee-Sook Roh, Ji-Hyun Lee, Ki-Hoon Song
BACKGROUND: Nodal melanocytic nevi (NN) encountered during sentinel lymph node biopsy (SLB) for malignant melanoma are usually difficult to distinguish from metastatic melanoma. However, NN have not been studied well in acral lentiginous melanoma (ALM) in Asian populations. OBJECTIVE: To investigate the clinical characteristics and significance of NN in SLBs from ALM patients. METHODS: We retrospectively analyzed 84 patients with ALM who underwent SLB between June 2010 and July 2017...
April 16, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29672887/young-age-is-associated-with-increased-rates-of-residual-recurrent-pediatric-differentiated-thyroid-carcinoma
#5
Sarah Hampson, Derek Stephens, Jonathan D Wasserman
OBJECTIVE: Differentiated thyroid carcinoma is rare in young children. There are conflicting data as to whether disease in this age group differs from that in adolescents and specifically, if it is more aggressive. Current practice guidelines do not differentiate treatment between these groups, but speculate that differences may exist. We sought to compare clinical features, treatment and outcomes between children (<12 years) and adolescents (12-18 years) with thyroid nodules and thyroid malignancy over a 20 year period...
April 19, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29672777/diep-flap-breast-reconstruction-complication-rate-in-previously-irradiated-internal-mammary-nodes
#6
Shirley Shechter, Ehud Arad, Amir Inbal, Or Friedman, Eyal Gur, Yoav Barnea
BACKGROUND:  Postmastectomy radiation therapy (PMRT) is a widely accepted treatment for locally advanced breast cancer. Some patients require additional boost radiation to the internal mammary nodes as the part of regional nodal irradiation (RNI). Delayed breast reconstruction with an autologous free flap using the internal mammary vessels for microvascular flap anastomosis is a common practice for these patients. The aim of our study was to evaluate the effect of RNI on autologous microvascular breast reconstruction...
April 19, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29672550/tumor-budding-is-an-independent-prognostic-marker-in-early-stage-oral-squamous-cell-carcinoma-with-special-reference-to-the-mode-of-invasion-and-worst-pattern-of-invasion
#7
Shota Shimizu, Akihiro Miyazaki, Tomoko Sonoda, Kazushige Koike, Kazuhiro Ogi, Jun-Ichi Kobayashi, Takeshi Kaneko, Tomohiro Igarashi, Megumi Ueda, Hironari Dehari, Akira Miyakawa, Tadashi Hasegawa, Hiroyoshi Hiratsuka
Pathologically proven regional lymph node metastasis affects the prognosis in early stage oral cancer. Therefore we investigated invasive tumor patterns predicting nodal involvement and survival in patients with clinically node-negative T1 and T2 oral squamous cell carcinoma (cT1,2N0M0 OSCC). Ninety-one cases of cT1,2N0M0 OSCC treated with transoral resection of the primary tumor were assessed based on 3 types of invasive tumor patterns on histopathologic and pancytokeratin-stained immunohistological sections: the mode of invasion, worst pattern of invasion (WPOI), and tumor budding...
2018: PloS One
https://www.readbyqxmd.com/read/29672407/survival-implications-of-increased-utilization-of-local-excision-for-ct1n0-esophageal-cancer
#8
Emily C Sturm, Whitney E Zahnd, John D Mellinger, Sabha Ganai
OBJECTIVE: We hypothesized that patients with cT1N0 esophageal cancer undergoing local excision would have lower survival compared with esophagectomy due to potential discordant staging. BACKGROUND: Local excision has become an attractive alternative for management of early esophageal cancer, avoiding the morbidity of esophagectomy. It is uncertain if occult nodal metastasis impacts survival. METHODS: An observational study was conducted using the National Cancer Database (1998-2012) for patients with clinical T1N0 esophageal cancer who underwent local excision (n = 1625) or esophagectomy (n = 3255)...
April 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29672406/number-of-examined-lymph-nodes-and-nodal-status-assessment-in-distal-pancreatectomy-for-body-tail-ductal-adenocarcinoma
#9
Giuseppe Malleo, Laura Maggino, Cristina R Ferrone, Giovanni Marchegiani, Mari Mino-Kenudson, Paola Capelli, Borislav Rusev, Keith D Lillemoe, Claudio Bassi, Carlos Fernàndez-Del Castillo, Roberto Salvia
OBJECTIVE: First, to assess the impact of the number of examined lymph nodes (ELNs) on staging and survival after distal pancreatectomy (DP) for pancreatic adenocarcinoma (PDAC). Second, to identify the minimum number of ELNs (MNELNs) ensuring an accurate detection of nodal involvement. Third, to reappraise the role of lymph node (LN) parameters, including N-status and lymph node ratio (LNR). BACKGROUND: In contrast with pancreatoduodenectomy, information on LN staging and the MNELN required in DP is lacking...
April 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29670365/prognostic-value-of-platelet-to-lymphocyte-ratio-in-pancreatic-cancer-a-comprehensive-meta-analysis-of-17-cohort-studies
#10
REVIEW
Yongping Zhou, Sijin Cheng, Abdel Hamid Fathy, Haixin Qian, Yongzhao Zhao
Background and aims: Several studies were conducted to explore the prognostic value of platelet-to-lymphocyte ratio (PLR) in pancreatic cancer and have reported contradictory results. This study aims to summarize the prognostic role of PLR in pancreatic cancer. Materials and methods: Embase, PubMed and Cochrane Library were completely searched. The cohort studies focusing on the prognostic role of PLR in pancreatic cancer were eligible. The overall survival (OS) and progression-free survival (PFS) were analyzed...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29669013/information-dropout-patterns-in-rad-phylogenomics-and-a-comparison-with-multilocus-sanger-data-in-a-species-rich-moth-genus
#11
Kyung Min Lee, Sami M Kivelä, Vladislav Ivanov, Axel Hausmann, Lauri Kaila, Niklas Wahlberg, Marko Mutanen
A rapid shift from traditional Sanger sequencing-based molecular methods to the phylogenomic approach with large numbers of loci is underway. Among phylogenomic methods, RAD (Restriction site Associated DNA) sequencing approaches have gained much attention as they enable rapid generation of up to thousands of loci randomly scattered across the genome and are suitable for non-model species. RAD data sets however suffer from large amounts of missing data and rapid locus dropout along with decreasing relatedness among taxa...
April 14, 2018: Systematic Biology
https://www.readbyqxmd.com/read/29668631/18f-fdg-pet-mr-imaging-of-lymphoma-nodal-target-lesions-comparison-of-pet-standardized-uptake-value-suv-with-mr-apparent-diffusion-coefficient-adc
#12
Hanna Bernstine, Liran Domachevsky, Meital Nidam, Natalia Goldberg, Ifat Abadi-Korek, Ofer Shpilberg, David Groshar
To compare positron emission tomography (PET) standardized uptake value (SUV) with magnetic resonance (MR) apparent diffusion coefficient (ADC) of nodal target lesions in patients with F-fluoro-2-deoxyglucose (FDG)-avid lymphomas by simultaneous PET/MR.Patients with histologically proven Hodgkin and non-Hodgkin lymphoma underwent PET/MR limited field of view of FDG-avid target nodal lesions. For PET images, a region of interest (ROI) was drawn around the target nodal lesion and the SUVmax and SUVmean was measured...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29668578/stard-how-many-lymph-nodals-needed-to-be-dissected-in-corpus-carcinoma
#13
Shuping Zhao, Dehua Ma, Yu Huang, Lei Zhang, Yuan Cao, Yawen Wang
During corpus carcinoma surgery, there is uncertainty as to how many lymph nodes should be dissected and examined to determine lymph invasion.In this study, we evaluated a beta-binominal model in data extracted from the Surveillance, Epidemiology, and End Results (SEER) database, which contains 22,372 complete records. We quantified the relationship between examined node number and the probability of missing invaded nodes. Survival curves were used for further validation.We found that for stage T1-T4, 1, 10, 23, and 37 lymph nodes, respectively, needed to be examined to minimize the missing positive nodal probability (1-nodal staging score, NSS) to less than 5%...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29668513/prognostic-value-of-metabolic-tumor-volume-and-total-lesion-glycolysis-in-esophageal-carcinoma-patients-treated-with-definitive-chemoradiotherapy
#14
Berna A Yildirim, Nese Torun, Ozan C Guler, Cem Onal
PURPOSE: The aim of this study was to evaluate the prognostic importance metabolic tumor volume (MTV), total lesion glycolysis (TLG), and standardized uptake value (SUV) in patients with esophageal cancer treated with definitive chemoradiotherapy. PATIENTS AND METHODS: Seventy-two esophageal cancer patients treated with definitive chemoradiotherapy [57 (79%) patients] or definitive radiotherapy [15 (21%) patients] were retrospectively analyzed. The regions equal to or greater than SUV of 2...
April 17, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29666810/the-8-th-tnm-edition-for-lung-cancer-a-critical-analysis
#15
REVIEW
Paul E Van Schil, Ramon Rami-Porta, Hisao Asamura
The 8th edition of the tumor, node and metastasis (TNM) classification provides several new categories and for the first time, some prospective data are included. The T (tumor) descriptor is further subdivided with 1 cm increments for T1 and T2 disease. For metastatic disease (M descriptor) the new M1b category comprises patients with only one metastasis in one distant organ, whereas M1c implies multiple distant metastases in one or several organs. There are no changes regarding the nodal map and N component but new categories are suggested for further analysis, subdividing the N1 and N2 descriptors into involvement of single or multiple lymph node stations...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666802/advances-in-radiotherapy-for-esophageal-cancer
#16
REVIEW
Wei Deng, Steven H Lin
Esophageal cancer is a common type of malignancy worldwide and usually requires multidisciplinary care. Radiotherapy plays an important part in management of the disease. During the past few years, researchers have made much progress about radiotherapy for esophageal cancer, which was revealed in every aspect of clinical practice. Neoadjuvant chemoradiotherapy remains the standard treatment for locally advanced esophageal cancer, whereas neoadjuvant chemotherapy appears to show less toxicities and non-inferior prognosis...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666800/strategies-of-nodal-staging-of-the-tnm-system-for-esophageal-cancer
#17
REVIEW
Wen-Ping Wang, Song-Lin He, Yu-Shang Yang, Long-Qi Chen
The 8th edition of UICC/AJCC TNM staging for esophageal cancer will start in use since 2018. The nodal staging in this version of TNM system remains unchanged from the 7th edition that based on the number of lymph nodes (LN) involved, except the limited revision of the regional LN map. In this review, N staging revision was evaluated from its initially simple definition of negative (N0) and positive (N1) LN(s) to the current positive node number based proposal. Meanwhile the disadvantages of current N staging were discussed...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666729/posttransplant-lymphoproliferative-disorder-presenting-as-testicular-lymphoma-in-a-kidney-transplant-recipient-a-case-report-and-review-of-the-literature
#18
Steve Omoruyi Obanor, Michelle Gruttadauria, Kayla Applebaum, Mohammad Eskandari, Michelle Lieberman Lubetzky, Stuart Greenstein
Posttransplant lymphoproliferative disorder (PTLD) is a malignancy caused by the immunosuppression that occurs after transplantation. It is primarily a nodal lesion but frequently it involves extranodal masses. Treatment is usually by reducing immunosuppressive therapy. Testicular lymphoma as PTLD is notably rare in documented literature and there is limited evidence of definitive treatment guidelines. This manuscript describes a patient who developed diffuse large B-cell lymphoma of his right testis one year following kidney transplantation...
2018: Case Reports in Nephrology
https://www.readbyqxmd.com/read/29666358/revisiting-atrioventricular-nodal-ablation-and-cardiac-pacing-of-atrial-fibrillation-in-a-patient-with-dextrocardia
#19
Munish Sharma, Ritesh Neupane, Koroush Khalighi
BACKGROUND Poorly controlled ventricular rate associated with atrial fibrillation (AF) leads to tachycardia-induced left ventricular dysfunction. Atrioventricular (AV) nodal ablation and cardiac pacing is the standard of care in refractory congestive heart failure (CHF) due to AF with moderate to rapid ventricular response that failed conventional medical therapy. If the patient is not a candidate for AF ablation with pulmonary vein isolation and elimination of AF foci, this is an effective approach, but it does have some challenges when done in a patient with dextrocardia and situs inversus...
April 18, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29666117/novel-insights-into-the-pathogenesis-of-t-cell-lymphomas
#20
John S Van Arnam, Megan S Lim, Kojo S J Elenitoba-Johnson
T-cell lymphomas are a heterogeneous group of rare malignancies with overlapping clinical, immunologic and histologic features. Recent advances in our understanding of T-cell differentiation based on gene expression profiling, next-generation sequencing (NGS) and transgenic mouse modeling studies have better elucidated the pathogenetic mechanisms underlying the diverse biology of T-cell lymphomas. These studies show that while genetic alterations in epigenetic modifiers are implicated in all subtypes of T-cell lymphomas, specific subtypes demonstrate enrichment for particular recurrent alterations targeting specific genes...
April 17, 2018: Blood
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