Abdallah Iddy Chaurembo, Na Xing, Francis Chanda, Yuan Li, Hui-Juan Zhang, Li-Dan Fu, Jian-Yuan Huang, Yun-Jing Xu, Wen-Hui Deng, Hao-Dong Cui, Xin-Yue Tong, Chi Shu, Han-Bin Lin, Kai-Xuan Lin
The impact of mitochondrial dysfunction on the pathogenesis of cardiovascular disease is increasing. However, the precise underlying mechanism remains unclear. Mitochondria produce cellular energy through oxidative phosphorylation while regulating calcium homeostasis, cellular respiration, and the production of biosynthetic chemicals. Nevertheless, problems related to cardiac energy metabolism, defective mitochondrial proteins, mitophagy, and structural changes in mitochondrial membranes can cause cardiovascular diseases via mitochondrial dysfunction...
April 1, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society