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https://www.readbyqxmd.com/read/28225803/bacterial-expression-correct-membrane-targeting-and-functional-folding-of-the-hiv-1-membrane-protein-vpu-using-a-periplasmic-signal-peptide
#1
Arpan Deb, William A Johnson, Alexander P Kline, Boston J Scott, Lydia R Meador, Dustin Srinivas, Jose M Martin-Garcia, Katerina Dörner, Chad R Borges, Rajeev Misra, Brenda G Hogue, Petra Fromme, Tsafrir S Mor
Viral protein U (Vpu) is a type-III integral membrane protein encoded by Human Immunodeficiency Virus-1 (HIV- 1). It is expressed in infected host cells and plays several roles in viral progeny escape from infected cells, including down-regulation of CD4 receptors. But key structure/function questions remain regarding the mechanisms by which the Vpu protein contributes to HIV-1 pathogenesis. Here we describe expression of Vpu in bacteria, its purification and characterization. We report the successful expression of PelB-Vpu in Escherichia coli using the leader peptide pectate lyase B (PelB) from Erwinia carotovora...
2017: PloS One
https://www.readbyqxmd.com/read/28225664/historic-leadership
#2
Ellen F Johnsen, Katherine J Pohlman
School nursing practice establishes itself in the midst of both education and nursing philosophies, ethics, standards, laws, and regulations. Treading these two worlds is difficult at times and requires that a school nurse possess a strong foundational knowledge base, seek professional collaboration, and navigate conflicting professional demands in order to promote student and public safety. This article is Part 2 of a four-part series that recounts the inspiring story of a school nurse, Ellen Johnsen, who did just that back in the 1980s in Broken Arrow, Oklahoma...
March 2017: NASN School Nurse
https://www.readbyqxmd.com/read/28225463/doctors-without-borders
#3
Val Wass, Lesley Southgate
The unprecedented demands of patient and population priorities created by globalization and escalating health and social inequities will not be met unless medical education changes. Educators have failed to move fast enough to create an education framework that meets current population needs. A new common set of professional values around global social accountability is necessary. Education borders must be broken down at three levels-societal-institutional, interpersonal, and individual.At a societal-institutional level, global health must be embraced as part of a philosophy of population needs, human rights, equity, and justice...
February 21, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28225288/screenpro-fh-screening-project-for-familial-hypercholesterolemia-in-central-southern-and-eastern-europe-basic-epidemiology
#4
Richard Češka, Tomáš Freiberger, Andrey V Susekov, György Paragh, Željko Reiner, Lale Tokgözoğlu, Katarína Rašlová, Maciej Banach, Branislav Vohnout, Andrzej Rynkiewicz, Assen Goudev, Gheorghe-Andrei Dan, Dan Gaiţă, Belma Pojskić, Ivan Pećin, Meral Kayıkçıoğlu, Olena Mitchenko, Marat V Ezhov, Gustavs Latkovskis, Žaneta Petrulionienė, Zlatko Fras, Nebojsa Tasić, Erkin M Mirrakhimov, Tolkun Murataliev, Alexander B Shek, Vladimír Tuka, Alexandros D Tselepis, Elie M Moubarak, Khalid Al Rasadi
INTRODUCTION: Despite great recent progress, familial hypercholesterolemia (FH) is still underestimated, under-diagnosed and thus undertreated worldwide. We have very little information on exact prevalence of patients with FH in the Central, Eastern and Southern Europe (CESE) region. The aim of the study was to describe the epidemiological situation in the CESE region from data available. METHODS: All local leaders of the ScreenPro FH project were asked to provide local data on (a) expert guess of FH prevalence (b) the medical facilities focused on FH already in place (c) the diagnostic criteria used (d) the number of patients already evidenced in local database and (e) the availability of therapeutic options (especially plasma apheresis)...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28224866/the-governing-body-nurse-as-a-clinical-commissioning-group-nurse-leader
#5
Angela Dempsey, Virginia Minogue
Aim The aim of this study was to understand governing body nurses' perspective of their effect on, and leadership of, clinical commissioning groups (CCGs). Method Semi-structured face-to-face and telephone interviews were conducted with a sample of governing body nurses, CCG chairs and regional chief nurses. A total of 23 individuals were interviewed. Findings Governing body nurses were overwhelmingly positive about their role and believed they had a positive effect on the CCG governing body. Specifically, they provided leadership for the quality agenda and compassionate practice...
February 22, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28224690/health-professionals-working-effectively-with-support-workers-to-enhance-the-quality-of-support-for-adults-with-intellectual-disabilities-a-meta-ethnography
#6
David Haines, Alexander Brown
BACKGROUND: Paid support workers are often central to the quality of life of adults with intellectual disabilities. Health and social care professionals increasingly carry out interventions indirectly through those support workers and therefore need to understand how best to collaborate. METHODS: This article synthesizes findings from the qualitative research of others investigating health professionals' work with support staff. From sixty-two articles retrieved from a database and journal search, seven met inclusion criteria and a meta-ethnographic synthesis allowed construction of an interpretive line-of-argument...
February 22, 2017: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/28224383/oncologist-and-organizational-factors-associated-with-variation-in-breast-cancer-multigene-testing
#7
Tracy A Lieu, G Thomas Ray, Stephanie R Prausnitz, Laurel A Habel, Stacey Alexeeff, Yan Li, Scott D Ramsey, Charles E Phelps, Neetu Chawla, Suzanne C O'Neill, Jeanne S Mandelblatt
PURPOSE: Multigene testing for breast cancer recurrence risk became available in 2007, yet many eligible patients remain untested. This study evaluated variation in testing rates, and oncologist and organizational factors associated with variation, in a setting without financial influences on testing. METHODS: We conducted a retrospective cohort study using electronic data and oncologist surveys within Kaiser Permanente Northern California, a large integrated health care system...
February 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28224346/dedication-increases-productivity-an-analysis-of-the-implementation-of-a-dedicated-medical-team-in-the-emergency-department
#8
Pedro Ramos, José Artur Paiva
BACKGROUND: In several European countries, emergency departments (EDs) now employ a dedicated team of full-time emergency medicine (EM) physicians, with a distinct leadership and bed-side emergency training, in all similar to other hospital departments. In Portugal, however, there are still two very different models for staffing EDs: a classic model, where EDs are mostly staffed with young inexperienced physicians from different medical departments who take turns in the ED in 12-h shifts and a dedicated model, recently implemented in some hospitals, where the ED is staffed by a team of doctors with specific medical competencies in emergency medicine that work full-time in the ED...
December 2017: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28224259/a-black-theological-response-to-race-based-medicine-reconciliation-in-minority-communities
#9
Kirk A Johnson
The harm race-based medicine inflicts on minority bodies through race-based experimentation and the false solutions a race-based drug ensues within minority communities provokes concern. Such areas analyze the minority patient in a physical proxy. Though the mind and body are important entities, we cannot forget about the spirit. Healing is not just a physical practice; it includes spiritual practice. Efficient medicine includes the holistic elements of the mind, body, and spirit. Therefore, the spiritual discipline of black theology can be used as a tool to mend the harms of race-based medicine...
February 21, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28223899/how-to-cure-the-sick-health-care-system-an-open-letter-to-president-trump-from-leaders-in-functional-integrative-natural-health-and-medicine
#10
EDITORIAL
Joseph Pizzorno
No abstract text is available yet for this article.
February 2017: Integrative Medicine
https://www.readbyqxmd.com/read/28223523/rps3-us3-promotes-mrna-binding-at-the-40s-ribosome-entry-channel-and-stabilizes-preinitiation-complexes-at-start-codons
#11
Jinsheng Dong, Colin Echeverría Aitken, Anil Thakur, Byung-Sik Shin, Jon R Lorsch, Alan G Hinnebusch
The eukaryotic 43S preinitiation complex (PIC) bearing Met-tRNAi(Met) in a ternary complex (TC) with eukaryotic initiation factor (eIF)2-GTP scans the mRNA leader for an AUG codon in favorable "Kozak" context. AUG recognition provokes rearrangement from an open PIC conformation with TC bound in a state not fully engaged with the P site ("POUT") to a closed, arrested conformation with TC tightly bound in the "PIN" state. Yeast ribosomal protein Rps3/uS3 resides in the mRNA entry channel of the 40S subunit and contacts mRNA via conserved residues whose functional importance was unknown...
February 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28222754/exploring-stakeholders-perceptions-of-a-task-shifting-strategy-for-hypertension-control-in-ghana-a-qualitative-study
#12
Juliet Iwelunmor, Joyce Gyamfi, Jacob Plange-Rhule, Sarah Blackstone, Nana Kofi Quakyi, Michael Ntim, Ferdinand Zizi, Kwasi Yeboah-Awudzi, Alexis Nang-Belfubah, Gbenga Ogedegbe
BACKGROUND: The purpose of this study was to explore stakeholders' perception of an on-going evidence-based task-shifting strategy for hypertension (TASSH) in 32 community health centers and district hospitals in Ghana. METHODS: Using focus group discussions and in-depth interviews, qualitative data were obtained from 81 key stakeholders including patients, nurses, and site directors of participating community health centers involved in the TASSH trial. Qualitative data were analyzed using open and axial coding techniques...
February 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28221340/archaeogenomic-evidence-reveals-prehistoric-matrilineal-dynasty
#13
Douglas J Kennett, Stephen Plog, Richard J George, Brendan J Culleton, Adam S Watson, Pontus Skoglund, Nadin Rohland, Swapan Mallick, Kristin Stewardson, Logan Kistler, Steven A LeBlanc, Peter M Whiteley, David Reich, George H Perry
For societies with writing systems, hereditary leadership is documented as one of the hallmarks of early political complexity and governance. In contrast, it is unknown whether hereditary succession played a role in the early formation of prehistoric complex societies that lacked writing. Here we use an archaeogenomic approach to identify an elite matriline that persisted between 800 and 1130 CE in Chaco Canyon, the centre of an expansive prehistoric complex society in the Southwestern United States. We show that nine individuals buried in an elite crypt at Pueblo Bonito, the largest structure in the canyon, have identical mitochondrial genomes...
February 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28221077/stanley-stan-kuczaj-ii-1950-2016
#14
Jennifer Vonk
Presents an obituary for Stanley (Stan) Kuczaj II who passed away suddenly on April 14, 2016 at the age of 65 in his home in Hattiesburg Mississippi. The field of comparative cognition and animal behavior lost a leader, a friend, and a mentor that day. At the time of his passing, Stan was a fellow and the president of the Society for Comparative Psychology and Behavioral Neuroscience, Division 6, of the American Psychological Association (APA). He was also a fellow of the American Association for the Advancement of Science, APA's Divisions 3 and 7, and the Psychonomic Society...
February 2017: American Psychologist
https://www.readbyqxmd.com/read/28220758/a-bio-inspired-electrocommunication-system-for-small-underwater-robots
#15
Wei Wang, Jindong Liu, Guangming Xie, Li Wen, Jianwei Zhang
Weakly electric fishes (Gymnotid and Mormyrid) use an electric field to communicate efficiently (termed electrocommunication) in the turbid waters of confined spaces where other communication modalities fail. Inspired by this biological phenomenon, we design an artificial electrocommunication system for small underwater robots and explore the capabilities of such an underwater robotic communication system. An analytical model for electrocommunication is derived to predict the effect of the key parameters such as electrode distance and emitter current of the system on the communication performance...
February 21, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28220746/readiness-to-adopt-a-performance-measurement-system-for-substance-abuse-treatment-findings-from-the-service-quality-measures-initiative
#16
B Myers, P Petersen Williams, K Johnson, R Govender, R Manderscheid, J R Koch
BACKGROUND: A performance measurement system - the Service Quality Measures (SQM) initiative - has been developed to monitor the quality of South Africa (SA)'s substance abuse treatment services. Identifying factors associated with readiness to adopt this system may inform strategies to facilitate its robust implementation. OBJECTIVE: To examine factors associated with readiness to adopt a performance measurement system among SA substance abuse treatment providers...
January 30, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28220312/preventing-hiv-and-hepatitis-infections-among-people-who-inject-drugs-leveraging-an-indiana-outbreak-response-to-break-the-impasse
#17
EDITORIAL
Jeffrey S Crowley, Gregorio A Millett
Providing clean needles through syringe services programs (SSPs) prevents the spread of disease among people who inject drugs (PWID). The recent HIV outbreak in Scott County, Indiana was a wakeup call with particular significance because modeling suggests that Scott County is but one of many counties in the United States highly vulnerable to an HIV outbreak among PWID. It is a painful recognition that some policy makers ignored the evidence in support of SSPs when it was primarily blacks in inner cities that were affected, yet swung into action in the wake of Scott County where 99% of the cases were white...
February 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28220251/triple-aim-improvement-for-individuals-services-and-society-in-dementia-care-the-dementianet-collaborative-care-approach
#18
M S Nieuwboer, A Richters, M A van der Marck
BACKGROUND: A redesigning of primary care is required to meet dementia patients' needs. In the Netherlands, current dementia care still falls short in areas including ad hoc collaboration, lack of feedback on quality to professionals involved, and insufficient implementation of established multidisciplinary guidelines. OBJECTIVE: DementiaNet is a collaborative care approach, which aims to reduce the burden of the disease on individuals, healthcare services and society via network-based care that encourages collaboration, enhances knowledge and skills and stimulates quality improvement cycles...
February 20, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28220097/women-do-not-belong-here-gender-work-identity-conflict-among-female-police-officers
#19
Jenny Veldman, Loes Meeussen, Colette Van Laar, Karen Phalet
The current paper examines antecedents and consequences of perceiving conflict between gender and work identities in male-dominated professions. In a study among 657 employees working in 85 teams in the police force, we investigated the effect of being different from team members in terms of gender on employees' perception that their team members see their gender identity as conflicting with their work identity. As expected in the police force as a male-dominated field, the results showed that gender-dissimilarity in the team was related to perceived gender-work identity conflict for women, and not for men...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28219632/alfred-pischinger-1899-1983-an-austrian-career-in-anatomy-continuing-through-national-socialism-to-postwar-leadership
#20
Sabine Hildebrandt, Gabriele Czarnowski
Despite intensified research efforts on the history of anatomy during National Socialism (NS), many aspects of this story still need further investigation. This study explores the life, work and politics of Alfred Pischinger, Chairman of the Institute for Embryology and Histology in Graz from 1936 to 1945, and in Vienna from 1958 to 1970, and is an addition to previous reports on careers in anatomy continuing through the Third Reich to the postwar period. Pischinger was an illegal NSDAP member in Austria, joined the SA in 1938, served as expert in racial hygiene, and as judge on the Genetic Health High Court of Graz...
February 17, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
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