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https://www.readbyqxmd.com/read/28324066/hippocampal-aromatization-modulates-spatial-memory-and-characteristics-of-the-synaptic-membrane-in-the-male-zebra-finch
#1
David J Bailey, Yekaterina V Makeyeva, Elizabeth R Paitel, Alyssa L Pedersen, Angel T Hon, Jordan A Gunderson, Colin J Saldanha
The estrogen-synthesizing enzyme aromatase is abundant at the synapse in the zebra finch hippocampus (HP) and its inhibition impairs spatial memory function. To more fully test the role of local estradiol (E2) synthesis in memory, the HP of adult male zebra finches was exposed to either control pellets or those containing the aromatase inhibitor ATD, ATD and E2, ATD and the G protein-coupled estrogen receptor (GPER) agonist G1, or the antagonist G15 alone. Birds were tested for spatial memory acquisition and performance, and HP levels of the postsynaptic protein PSD95 were measured...
January 27, 2017: Endocrinology
https://www.readbyqxmd.com/read/28323874/c-type-allatostatins-mimic-stress-related-effects-of-alarm-pheromone-on-honey-bee-learning-and-memory-recall
#2
Elodie Urlacher, Jean-Marc Devaud, Alison R Mercer
As honey bee populations worldwide are declining there is an urgent need for a deeper understanding of stress reactivity in these important insects. Our data indicate that stress responses in bees (Apis mellifera L.) may be mediated by neuropeptides identified, on the basis of sequence similarities, as allatostatins (ASTA, ASTC and ASTCC). Effects of allatostatin injection are compared with stress-related changes in learning performance induced by the honeybee alarm pheromone, isopentylacetate (IPA). We find that bees can exhibit two markedly different responses to IPA, with opposing effects on learning behaviour and memory generalisation, and that strikingly similar responses can be elicited by allatostatins, in particular ASTCC...
2017: PloS One
https://www.readbyqxmd.com/read/28323681/predictors-that-a-diagnosis-of-mild-cognitive-impairment-will-remain-stable-3-years-later
#3
Matthew A Clem, Ryan P Holliday, Seema Pandya, Linda S Hynan, Laura H Lacritz, Fu L Woon
BACKGROUND AND OBJECTIVE: In half to two thirds of patients who are diagnosed with mild cognitive impairment (MCI), the diagnosis neither converts to dementia nor reverts to normal cognition; however, little is known about predictors of MCI stability. Our study aimed to identify those predictors. METHODS: We obtained 3-year longitudinal data from the National Alzheimer's Coordinating Center Uniform Data Set for patients with a baseline diagnosis of MCI. To predict MCI stability, we used the patients' baseline data to conduct three logistic regression models: demographics, global function, and neuropsychological performance...
March 2017: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/28323680/transient-global-amnesia-commentary-on-trip-gabriel-s-first-person-account
#4
Howard S Kirshner
This paper comments on a companion article, a first-person account of an episode of transient global amnesia written by New York Times reporter Trip Gabriel (Gabriel T. 2017. Cogn Behav Neurol. 30:1-4). Mr Gabriel describes having no memories of a cold, rainy day that he had spent on a sailboat competing in two races. The episode may have been triggered by his exposure to water. Afterward, the skipper recalled that Mr Gabriel had functioned fine on the boat, although after returning to shore he needed help finding his car...
March 2017: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/28323513/transmembrane-tnf-dependent-uptake-of-anti-tnf-antibodies
#5
Arun Deora, Subramanya Hegde, Jacqueline Lee, Chee-Ho Choi, Qing Chang, Cheryl Lee, Lucia Eaton, Hua Tang, Dongdong Wang, David Lee, Mark Michalak, Medha Tomlinson, Qingfeng Tao, Nidhi Gaur, Bohdan Harvey, Shaun McLoughlin, Boris Labkovsky, Tariq Ghayur
TNF-alpha (TNF), a pro-inflammatory cytokine is synthesized as a 26 kDa protein, anchors in the plasma membrane as transmembrane TNF (TmTNF), and is subjected to proteolysis by the TNF-alpha converting enzyme (TACE) to release the 15 kDa form of soluble TNF (sTNF). TmTNF and sTNF interact with two distinct receptors, TNF-R1 (p55) and TNF-R2 (p75), to mediate the multiple biological effects of TNF described to date. Several anti-TNF biologics that bind to both forms of TNF and block their interactions with the TNF receptors are now approved for the treatment of a variety of immune-mediated diseases...
March 21, 2017: MAbs
https://www.readbyqxmd.com/read/28323462/scaling-up-a-water-sanitation-and-hygiene-program-in-rural-bangladesh-the-role-of-program-implementation
#6
Jade Benjamin-Chung, Sonia Sultana, Amal K Halder, Mohammed Ali Ahsan, Benjamin F Arnold, Alan E Hubbard, Leanne Unicomb, Stephen P Luby, John M Colford
OBJECTIVES: To evaluate whether the quality of implementation of a water, sanitation, and hygiene program called SHEWA-B and delivered by UNICEF to 20 million people in rural Bangladesh was associated with health behaviors and sanitation infrastructure access. METHODS: We surveyed 33 027 households targeted by SHEWA-B and 1110 SHEWA-B hygiene promoters in 2011 and 2012. We developed an implementation quality index and compared the probability of health behaviors and sanitation infrastructure access in counterfactual scenarios over the range of implementation quality...
March 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28319238/behavioral-and-neural-constraints-on-hierarchical-representations
#7
Odelia Schwartz, Luis Gonzalo Sanchez Giraldo
Central to behavior and cognition is the way that sensory stimuli are represented in neural systems. The distributions over such stimuli enjoy rich structure; however, how the brain captures and exploits these regularities is unclear. Here, we consider different sources of perhaps the most prevalent form of structure, namely hierarchies, in one of its most prevalent cases, namely the representation of images. We review experimental approaches across a range of subfields, spanning inference, memory recall, and visual adaptation, to investigate how these constrain hierarchical representations...
March 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28319105/link-of-dietary-patterns-with-metabolic-syndrome-analysis-of-the-national-health-and-nutrition-examination-survey
#8
M Mazidi, S Pennathur, F Afshinnia
BACKGROUND: Population-based interventions aimed at halting the increasing prevalence of metabolic syndrome (MetS) require thorough understanding of dietary interplays. Objective is to identify the independent dietary nutrients associated with MetS and its components using dietary pattern identification and the single-nutrient approaches in The United States. METHODS: This is a cross-sectional observation. Participants are selected from the National Health and Nutrition Examination Survey (NHANES) with available dietary intake, biochemical and anthropometrical data from 2001 to 2012...
March 20, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28318680/nephrogenic-systemic-fibrosis-a-15-year-retrospective-study-at-a-single-tertiary-care-center
#9
Janice Wilson, Kristyna Gleghorn, Quincy Seigel, Brent Kelly
BACKGROUND: Despite multiple therapeutic approaches for nephrogenic systemic fibrosis (NSF), no single treatment has convincingly shown consistent benefit. The most successful outcomes have been associated with recovery of renal function, although evidence remains limited and past studies have been inconclusive. OBJECTIVE: We sought to investigate whether improvement of renal function via successful transplantation or via return of renal function after acute kidney injury correlates with improvement of NSF, and to further characterize the clinical features and progression of NSF...
March 15, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28318518/-returning-to-work-after-an-acute-coronary-syndrome-when-waiting-is-wasting
#10
F Latil, M C Iliou, C Boileau, J X Pietri, C Lechien, P Ha-Vinh, C Guimond
BACKGROUND: Return to work (RTW) after acute coronary syndrome (ACS) is an important issue for the patient's future. AIMS: The study aim was to determine whether RTW practice complies with guidelines or is delayed by failure in patient management. We analysed the factors influencing RTW beyond the 90-day period recommended by guidelines. METHODS: We conducted a survey of 216 self-employed workers admitted to the hospital for ACS using self-report questionnaires and medical examination...
March 16, 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/28318482/cross-sectional-analysis-of-eating-patterns-and-snacking-in-the-us-feeding-infants-and-toddlers-study-2008
#11
Denise M Deming, Kathleen C Reidy, Mary Kay Fox, Ronette R Briefel, Emma Jacquier, Alison L Eldridge
OBJECTIVE: To explore eating patterns and snacking among US infants, toddlers and pre-school children. DESIGN: The Feeding Infants and Toddlers Study (FITS) 2008 was a cross-sectional national survey of children aged 6-47 months, weighted to reflect US age and racial/ethnic distributions. Dietary data were collected using one multiple-pass 24h recall. Eating occasions were categorized as meals, snacks or other (comprised of all feedings of breast milk and/or infant formula)...
March 20, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28318456/international-outbreak-of-multiple-salmonella-serotype-infections-linked-to-sprouted-chia-seed-powder-usa-and-canada-2013-2014
#12
R R Harvey, K E Heiman Marshall, L Burnworth, M Hamel, J Tataryn, J Cutler, K Meghnath, A Wellman, K Irvin, L Isaac, K Chau, A Locas, J Kohl, P A Huth, D Nicholas, E Traphagen, K Soto, L Mank, K Holmes-Talbot, M Needham, A Barnes, B Adcock, L Honish, L Chui, M Taylor, C Gaulin, S Bekal, B Warshawsky, L Hobbs, L R Tschetter, A Surin, S Lance, M E Wise, I Williams, L Gieraltowski
Salmonella is a leading cause of bacterial foodborne illness. We report the collaborative investigative efforts of US and Canadian public health officials during the 2013-2014 international outbreak of multiple Salmonella serotype infections linked to sprouted chia seed powder. The investigation included open-ended interviews of ill persons, traceback, product testing, facility inspections, and trace forward. Ninety-four persons infected with outbreak strains from 16 states and four provinces were identified; 21% were hospitalized and none died...
March 20, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28318415/is-the-hebb-repetition-task-a-reliable-measure-of-individual-differences-in-sequence-learning
#13
Louisa Bogaerts, Noam Siegelman, Tali Ben-Porat, Ram Frost
The Hebb repetition task, an operationalization of long-term sequence learning through repetition, is the focus of renewed interest, as it is taken to provide a laboratory analogue for naturalistic vocabulary acquisition. Indeed, recent studies have consistently related performance in the Hebb repetition task with a range of linguistic (dis)abilities. However, in spite of the growing interest in the Hebb repetition effect as a theoretical construct, no previous research has ever tested whether the task used to assess Hebb learning offers a stable and reliable measure of individual performance in sequence learning...
March 20, 2017: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/28317646/clinical-validity-of-delayed-recall-tests-as-a-gateway-biomarker-for-alzheimer-s-disease-in-the-context-of-a-structured-5-phase-development-framework
#14
REVIEW
Chiara Cerami, Bruno Dubois, Marina Boccardi, Andreas U Monsch, Jean Francois Demonet, Stefano F Cappa
Although Alzheimer's disease criteria promote the use of biomarkers, their maturity in clinical routine still needs to be assessed. In the light of the oncology framework, we conducted a literature review on measures used to assess delayed recall impairment due to medial temporal lobe dysfunction (i.e., free and cued word list recall tests). Ample evidence is available for phases 1 (rationale for use), 2 (discriminative ability), and 3 (early detection ability) for many of the tests in routine use. Evidence about phase 4 (performance in real world) and phase 5 (quantify impact and costs) is yet to come...
April 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28317003/peri-operative-inflammatory-cytokines-in-plasma-of-the-elderly-correlate-in-prospective-study-with-postoperative-changes-in-cognitive-test-scores
#15
R Kline, E Wong, M Haile, S Didehvar, S Farber, A Sacks, E Pirraglia, M J de Leon, A Bekker
Increasingly, postoperative cognitive dysfunction (POCD) is recognized as a complication after surgery in the elderly; but it's etiology remains unclear. Here we examine changes in cytokine levels during both the pre-operative and postoperative period, comparing them with long term variation in cognitive test scores. Forty-one patients aged 65 and older undergoing major surgery with general anesthesia were recruited after written consent in this IRB approved study. Thirty went on to complete this prospective, non-interven-tional and non-randomized study...
August 2016: Int J Anesthesiol Res
https://www.readbyqxmd.com/read/28316908/exploring-childhood-obesity-prevention-among-diverse-ethnic-groups-in-schools-and-places-of-worship-recruitment-acceptability-and-feasibility-of-data-collection-and-intervention-components
#16
Maria Maynard, Graham Baker, Seeromanie Harding
Small-scale, detailed exploration of the recruitment, assessment, and evaluation processes of obesity intervention among minority ethnic children. The study took place in schools and places of worship during 2008-2010 in London, UK. Measures included 3-day food diaries, 24 h dietary recalls, the Youth Physical Activity Questionnaire, accelerometry, and diet and physical activity self-efficacy questionnaires. Potential intervention components were evaluated via observation, questionnaires, and focus group discussions...
June 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28316893/contrasting-determinants-for-the-introduction-and-establishment-success-of-exotic-birds-in-taiwan-using-decision-trees-models
#17
Shih-Hsiung Liang, Bruno Andreas Walther, Bao-Sen Shieh
BACKGROUND: Biological invasions have become a major threat to biodiversity, and identifying determinants underlying success at different stages of the invasion process is essential for both prevention management and testing ecological theories. To investigate variables associated with different stages of the invasion process in a local region such as Taiwan, potential problems using traditional parametric analyses include too many variables of different data types (nominal, ordinal, and interval) and a relatively small data set with too many missing values...
2017: PeerJ
https://www.readbyqxmd.com/read/28316365/extracting-databases-from-dark-data-with-deepdive
#18
Ce Zhang, Jaeho Shin, Christopher Ré, Michael Cafarella, Feng Niu
DeepDive is a system for extracting relational databases from dark data: the mass of text, tables, and images that are widely collected and stored but which cannot be exploited by standard relational tools. If the information in dark data - scientific papers, Web classified ads, customer service notes, and so on - were instead in a relational database, it would give analysts a massive and valuable new set of "big data." DeepDive is distinctive when compared to previous information extraction systems in its ability to obtain very high precision and recall at reasonable engineering cost; in a number of applications, we have used DeepDive to create databases with accuracy that meets that of human annotators...
June 2016: Proceedings
https://www.readbyqxmd.com/read/28316271/visuospatial-declarative-learning-despite-profound-verbal-declarative-amnesia-in-korsakoff-s-syndrome
#19
Erik Oudman, Albert Postma, Tanja C W Nijboer, Jan W Wijnia, Stefan Van der Stigchel
Korsakoff's syndrome (KS) is a neuropsychiatric disorder characterised by severe amnesia. Although the presence of impairments in memory has long been acknowledged, there is a lack of knowledge about the precise characteristics of declarative memory capacities in order to implement memory rehabilitation. In this study, we investigated the extent to which patients diagnosed with KS have preserved declarative memory capacities in working memory, long-term memory encoding or long-term memory recall operations, and whether these capacities are most preserved for verbal or visuospatial content...
March 20, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28316122/digital-workflow-for-fixed-implant-rehabilitation-of-an-extremely-atrophic-edentulous-mandible-in-three-appointments
#20
Panos Papaspyridakos, Neha Rajput, Yukio Kudara, Hans-Peter Weber
OBJECTIVE: To present a rationale to reduce treatment complexity, number of surgeries, and overall treatment time for patients with extreme mandibular ridge deficiency. CLINICAL CONSIDERATIONS: A 67-year-old fully edentulous male presented with a chief complaint of poor retention and stability of the mandibular complete denture with consequent discomfort and inability to chew. A novel 3-appointment protocol from guided implant placement to definitive prosthesis delivery was implemented...
March 18, 2017: Journal of Esthetic and Restorative Dentistry
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