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https://www.readbyqxmd.com/read/29037022/radiation-recall-dermatitis-triggered-by-sorafenib-after-radiation-therapy-for-hepatocellular-carcinoma
#1
Gwi Eon Kim, Hee-Sung Song, Ki Jung Ahn, Young Suk Kim
Sorafenib is widely used for unresectable and metastatic hepatocellular carcinomas. Radiation recall dermatitis (RRD) is an acute inflammatory reaction confined to previously irradiated skin that occurs after the administration of certain drugs. RRD after sorafenib treatment is rare; five cases have been reported thus far. We describe a 44-year-old man irradiated for chest wall bone metastasis from hepatocellular carcinoma. Eight days after radiotherapy completion, systemic therapy for metastatic hepatocellular carcinoma was initiated with sorafenib treatment...
September 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29036893/development-and-validation-of-a-food-frequency-questionnaire-to-estimate-intake-among-children-and-adolescents-in-urban-peru
#2
Carly A Rodriguez, Emily R Smith, Eduardo Villamor, Nelly Zavaleta, Graciela Respicio-Torres, Carmen Contreras, Sara Perea, Judith Jimenez, Karen Tintaya, Leonid Lecca, Megan B Murray, Molly F Franke
Tools to assess intake among children in Latin America are limited. We developed and assessed the reproducibility and validity of a semi-quantitative food frequency questionnaire (FFQ) administered to children, adolescents, and their caregivers in Lima, Peru. We conducted 24-h diet recalls (DRs) and focus groups to develop a locally-tailored FFQ prototype for children aged 0-14 years. To validate the FFQ, we administered two FFQs and three DRs to children and/or their caregivers (N = 120) over six months. We examined FFQ reproducibility by quartile agreement and Pearson correlation coefficients, and validity by quartile agreement and correlation with DRs...
October 14, 2017: Nutrients
https://www.readbyqxmd.com/read/29036849/newly-developed-learning-and-verbal-memory-test-tamv-i-normative-data-for-spanish-speaking-pediatric-population
#3
D Rivera, L Olabarrieta-Landa, B V Rabago Barajas, M J Irías Escher, M Saracostti Schwartzman, R Ferrer-Cascales, P Martín-Lobo, J A Calderón, M A Aguilar Uriarte, A I Peñalver Guia, R Camlla Ynga, C E García-Guerrero, I Fernandez-Agis, A García-Gómez-Pastrana, J A Ibañéz-Alfonso, H Gómez, J Galarza-Del-Angel, C García de la Cadena, J C Arango-Lasprilla
OBJECTIVE: To generate normative data for the Learning and Verbal Memory Test (TAMV-I) in Spanish-speaking pediatric populations. METHOD: The sample consisted of 4,373 healthy children from nine countries in Latin America (Chile, Cuba, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Peru, and Puerto Rico) and Spain. Each participant was administered the TAMV-I as part of a larger neuropsychological battery. Free recall, memory delay and recognition scores were normed using multiple linear regressions and standard deviations of residual values...
October 10, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/29036577/biobankuniverse-automatic-matchmaking-between-datasets-for-biobank-data-discovery-and-integration
#4
Chao Pang, Fleur Kelpin, David van Enckevort, Niina Eklund, Kaisa Silander, Dennis Hendriksen, Mark de Haan, Jonathan Jetten, Tommy de Boer, Bart Charbon, Petr Holub, Hans Hillege, Morris A Swertz
Motivation: Biobanks are indispensable for large-scale genetic/epidemiological studies, yet it remains difficult for researchers to determine which biobanks contain data matching their research questions. Results: To overcome this, we developed a new matching algorithm that identifies pairs of related data elements between biobanks and research variables with high precision and recall. It integrates lexical comparison, Unified Medical Language System ontology tagging and semantic query expansion...
August 2, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036411/relative-validity-of-nutrient-intakes-assessed-by-questionnaire-24-hour-recalls-and-diet-records-compared-with-urinary-recovery-and-plasma-concentration-biomarkers-findings-for-women
#5
Changzheng Yuan, Donna Spiegelman, Eric B Rimm, Bernard A Rosner, Meir J Stampfer, Junaidah B Barnett, Jorge E Chavarro, Jennifer C Rood, Lisa J Harnack, Laura K Sampson, Walter C Willett
The authors evaluated the performance of a semi-quantitative food frequency questionnaire (SFFQ), web-based 24-hour recalls (ASA24s), and 7-day dietary records (7DDRs) compared to biomarkers among 627 women in Women's Lifestyle Validation Study (US, 2010-2012). Two paper SFFQs, one web-based SFFQ, four ASA24s (beta version), two 7DDRs, four 24-hour urine samples, one doubly-labeled water (repeated among 76 participants), and two fasting blood samples were collected over a 15-months-period. Dietary variables evaluated were energy, energy-adjusted intakes of protein, sodium, potassium, and specific fatty acids, carotenoids, α-tocopherol, retinol and folate...
October 4, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29036382/musitedeep-a-deep-learning-framework-for-general-and-kinase-specific-phosphorylation-site-prediction
#6
Duolin Wang, Shuai Zeng, Chunhui Xu, Wangren Qiu, Yanchun Liang, Trupti Joshi, Dong Xu
Motivation: Computational methods for phosphorylation site prediction play important roles in protein function studies and experimental design. Most existing methods are based on feature extraction, which may result in incomplete or biased features. Deep learning as the cutting-edge machine learning method has the ability to automatically discover complex representations of phosphorylation patterns from the raw sequences, and hence it provides a powerful tool for improvement of phosphorylation site prediction...
August 3, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036359/profia-a-data-preprocessing-workflow-for-flow-injection-analysis-coupled-to-high-resolution-mass-spectrometry
#7
Alexis Delabrière, Ulli M Hohenester, Benoit Colsch, Christophe Junot, François Fenaille, Etienne A Thévenot
Motivation: Flow Injection Analysis coupled to High-Resolution Mass Spectrometry (FIA-HRMS) is a promising approach for high-throughput metabolomics. FIA-HRMS data, however, cannot be preprocessed with current software tools which rely on liquid chromatography separation, or handle low resolution data only. Results: We thus developed the proFIA package, which implements a suite of innovative algorithms to preprocess FIA-HRMS raw files, and generates the table of peak intensities...
July 14, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29035101/biofilm-formation-antimicrobial-resistance-and-sanitizer-tolerance-of-salmonella-enterica-strains-isolated-from-beef-trim
#8
Rong Wang, John W Schmidt, Dayna M Harhay, Joseph M Bosilevac, David A King, Terrance M Arthur
In the beef industry, product contamination by Salmonella enterica is a serious public health concern, which may result in human infection and cause significant financial loss due to product recalls. Currently, the precise mechanism and pathogen source responsible for Salmonella contamination in commercial establishments are not well understood. We characterized 89 S. enterica strains isolated from beef trim with respect to their biofilm-forming ability, antimicrobial resistance, and biofilm cell survival/recovery growth after sanitizer exposure...
October 16, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/29035078/overrepresentation-of-extreme-events-in-decision-making-reflects-rational-use-of-cognitive-resources
#9
Falk Lieder, Thomas L Griffiths, Ming Hsu
People's decisions and judgments are disproportionately swayed by improbable but extreme eventualities, such as terrorism, that come to mind easily. This article explores whether such availability biases can be reconciled with rational information processing by taking into account the fact that decision makers value their time and have limited cognitive resources. Our analysis suggests that to make optimal use of their finite time decision makers should overrepresent the most important potential consequences relative to less important, put potentially more probable, outcomes...
October 16, 2017: Psychological Review
https://www.readbyqxmd.com/read/29034527/age-of-onset-or-age-at-assessment-that-is-the-question-estimating-newly-incident-alcohol-drinking-and-rapid-transition-to-heavy-drinking-in-the-united-states-2002-2014
#10
Hui G Cheng, Catalina Lopez-Quintero, James C Anthony
Age-specific incidence estimates are important and useful facts in psychiatric epidemiology, but incidence estimation can be challenging. Methods artifacts are possible. In the United States, where the minimum legal drinking age is 21 years, recent cross-sectional field research on 12- to 25-year-olds applied conventional "age-at-assessment" approaches (AAA) for incidence estimation based on 12-month recall. Estimates disclosed unexpected nonlinear patterns in age-specific incidence estimates for both drinking onset and for transitioning from first drink to heavy drinking...
October 15, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/29034449/nitrous-oxide-based-vs-nitrous-oxide-free-general-anaesthesia-and-accidental-awareness-in-surgical-patients-an-abridged-cochrane-systematic-review
#11
REVIEW
J Hounsome, J Greenhalgh, O J Schofield-Robinson, S R Lewis, T M Cook, A F Smith
Accidental awareness during general anaesthesia can arise from a failure to deliver sufficient anaesthetic agent, or from a patient's resistance to an expected sufficient dose of such an agent. Awareness is 'explicit' if the patient is subsequently able to recall the event. We conducted a systematic review into the effect of nitrous oxide used as part of a general anaesthetic on the risk of accidental awareness in people over the age of five years undergoing general anaesthesia for surgery. We included 15 randomised controlled trials, 14 of which, representing a total of 3439 participants, were included in our primary analysis of the frequency of accidental awareness events...
October 16, 2017: Anaesthesia
https://www.readbyqxmd.com/read/29033987/dietary-practices-and-nutritional-profile-of-female-nurses-from-government-hospitals-in-delhi-india
#12
Shipra Gupta
BACKGROUND: Nursing is a demanding profession and nurses face a considerable degree of stress at work that can adversely influence their dietary practices and nutritional status. The current study was designed to conduct a preliminary investigation of the dietary practices and nutritional profile of nurses from government hospitals in Delhi. MATERIALS AND METHODS: A cross-sectional descriptive study was carried out among 80 female nurses aged between 25 and 39 years from government hospitals...
September 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29033874/testing-the-motor-simulation-account-of-source-errors-for-actions-in-recall
#13
Nicholas Lange, Timothy J Hollins, Patric Bach
Observing someone else perform an action can lead to false memories of self-performance - the observation inflation effect. One explanation is that action simulation via mirror neuron activation during action observation is responsible for observation inflation by enriching memories of observed actions with motor representations. In three experiments we investigated this account of source memory failures, using a novel paradigm that minimized influences of verbalization and prior object knowledge. Participants worked in pairs to take turns acting out geometric shapes and letters...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29032899/th1-epitope-peptides-induce-protective-immunity-against-rickettsia-rickettsii-infection-in-c3h-hen-mice
#14
Wenping Gong, Xiaolu Xiong, Pengcheng Wang, Jun Jiao, Xiaomei Yang, Bohai Wen
Rickettsia rickettsii is the causative pathogen of Rocky Mountain spotted fever (RMSF). Adr2, YbgF and OmpB are protective antigens of R. rickettsii. In this study, 90 candidate peptides were selected from these antigens based on their high-affinity binding capacity for the MHC class II molecule H2 I-A or H2 I-E using bioinformatic methods. Six peptides were determined using ELISPOT assay to be immunodominant based on the IFN-γ recall responses of CD4(+) T cells from mice immunized with R. rickettsii. Six nucleotide sequences encoding the immunodominant peptides were linked in series and inserted into a plasmid for expression in Escherichia coli cells, resulting in a new, recombinant polypeptide termed GWP...
October 9, 2017: Vaccine
https://www.readbyqxmd.com/read/29032787/ultra-processed-foods-protein-leverage-and-energy-intake-in-the-usa
#15
Euridice Martínez Steele, David Raubenheimer, Stephen J Simpson, Larissa Galastri Baraldi, Carlos A Monteiro
OBJECTIVE: Experimental studies have shown that human macronutrient regulation minimizes variation in absolute protein intake and consequently energy intake varies passively with dietary protein density ('protein leverage'). According to the 'protein leverage hypothesis' (PLH), protein leverage interacts with a reduction in dietary protein density to drive energy overconsumption and obesity. Worldwide increase in consumption of ultra-processed foods (UPF) has been hypothesized to be an important determinant of dietary protein dilution, and consequently an ecological driving force of energy overconsumption and the obesity pandemic...
October 16, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/29032207/the-effect-of-unsuccessful-retrieval-on-children-s-subsequent-learning
#16
Paula Carneiro, Ana Lapa, Bridgid Finn
It is well known that successful retrieval enhances subsequent adults' learning by promoting long-term retention. Recent research has also found benefits from unsuccessful retrieval, but the evidence is not as clear-cut when the participants are children. In this study, we employed a methodology based on guessing-the weak associate paradigm-to test whether children can learn from generated errors or whether errors are harmful for learning. We tested second- and third-grade children in Experiment 1 and tested preschool and kindergarten children in Experiment 2...
October 12, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29032015/possible-positive-effect-of-the-apoe-%C3%AE%C2%B52-allele-on-cognition-in-early-to-mid-adult-life
#17
I Sinclair Lindsey, Christopher W Pleydell-Pearce, N M Ian Day
BACKGROUND: ε4 allele possession is associated with an increased risk of Alzheimer's disease. Its effects earlier in life are less well understood. Previous studies have reported both detrimental effects and a lack of effect on cognition outside dementia. We used genotype based recall from the ALSPAC study to investigate whether APOE genotype influences cognition in earlier adult life. METHODS: We invited all individuals with the rarer ε22 or ε44 genotypes and equal numbers of those with ε32, ε33 or ε34 APOE genotypes (total n invited =1936, ages 23-67)...
October 11, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29031808/specific-disruption-of-contextual-memory-recall-by-sparse-additional-activity-in-the-dentate-gyrus
#18
Hye-Yeon Cho, Mujun Kim, Jin-Hee Han
The dentate gyrus (DG) of the hippocampus is essential for contextual and spatial memory processing. While lesion or silencing of the DG impairs contextual memory encoding and recall, overly activated DG also prevents proper memory retrieval. Abnormally elevated activity in the DG is repeatedly reported in amnesic mild cognitive impairment (aMCI) patients or aged adults. Although the correlation between memory failure and abnormally active hippocampus is clear, their causal relationship or the underlying nature of such interfering activity is not well understood...
October 12, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29031531/a-functional-connectivity-based-neuromarker-of-sustained-attention-generalizes-to-predict-recall-in-a-reading-task
#19
David C Jangraw, Javier Gonzalez-Castillo, Daniel A Handwerker, Merage Ghane, Monica D Rosenberg, Puja Panwar, Peter A Bandettini
Sustaining attention to the task at hand is a crucial part of everyday life, from following a lecture at school to maintaining focus while driving. Lapses in sustained attention are frequent and often problematic, with conditions such as attention deficit hyperactivity disorder affecting millions of people worldwide. Recent work has had some success in finding signatures of sustained attention in whole-brain functional connectivity (FC) measures during basic tasks, but since FC can be dynamic and task-dependent, it remains unclear how fully these signatures would generalize to a more complex and naturalistic scenario...
October 11, 2017: NeuroImage
https://www.readbyqxmd.com/read/29031232/does-prior-domain-specific-content-knowledge-influence-students-recall-of-arguments-surrounding-interdisciplinary-topics
#20
Hiemke K Schmidt, Martin Rothgangel, Dietmar Grube
Awareness of various arguments can help interactants present opinions, stress points, and build counterarguments during discussions. At school, some topics are taught in a way that students learn to accumulate knowledge and gather arguments, and later employ them during debates. Prior knowledge may facilitate recalling information on well structured, fact-based topics, but does it facilitate recalling arguments during discussions on complex, interdisciplinary topics? We assessed the prior knowledge in domains related to a bioethical topic of 277 students from Germany (approximately 15 years old), their interest in the topic, and their general knowledge...
October 11, 2017: Journal of Adolescence
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