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https://www.readbyqxmd.com/read/28813000/an-ameliorated-prediction-of-drug-target-interactions-based-on-multi-scale-discrete-wavelet-transform-and-network-features
#1
Cong Shen, Yijie Ding, Jijun Tang, Xinying Xu, Fei Guo
The prediction of drug-target interactions (DTIs) via computational technology plays a crucial role in reducing the experimental cost. A variety of state-of-the-art methods have been proposed to improve the accuracy of DTI predictions. In this paper, we propose a kind of drug-target interactions predictor adopting multi-scale discrete wavelet transform and network features (named as DAWN) in order to solve the DTIs prediction problem. We encode the drug molecule by a substructure fingerprint with a dictionary of substructure patterns...
August 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28812579/reproducibility-and-relative-validity-of-a-food-frequency-questionnaire-to-estimate-intake-of-dietary-phylloquinone-and-menaquinones
#2
S R Zwakenberg, A I P Engelen, G W Dalmeijer, S L Booth, C Vermeer, J J M M Drijvers, M C Ocke, E J M Feskens, Y T van der Schouw, J W J Beulens
BACKGROUND/OBJECTIVES: This study aims to investigate the reproducibility and relative validity of the Dutch food frequency questionnaire (FFQ), to estimate intake of dietary phylloquinone and menaquinones compared with 24-h dietary recalls (24HDRs) and plasma markers of vitamin K status. SUBJECTS/METHODS: In a cross-sectional study among 63 men and 58 women, the FFQ was completed three times over a 1-year period and the reproducibility was calculated over these measurements...
August 16, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28812031/early-single-sport-specialization-a-survey-of-3090-high-school-collegiate-and-professional-athletes
#3
Patrick S Buckley, Meghan Bishop, Patrick Kane, Michael C Ciccotti, Stephen Selverian, Dominique Exume, William Emper, Kevin B Freedman, Sommer Hammoud, Steven B Cohen, Michael G Ciccotti
BACKGROUND: Youth participation in organized sports in the United States is rising, with many athletes focusing on a single sport at an increasingly younger age. PURPOSE: To retrospectively compare single-sport specialization in current high school (HS), collegiate, and professional athletes with regard to the rate and age of specialization, the number of months per year of single-sport training, and the athlete's perception of injury related to specialization. STUDY DESIGN: Cross-sectional study; Level of evidence, 3...
July 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28811735/asian-american-dietary-sources-of-sodium-and-salt-behaviors-compared-with-other-racial-ethnic-groups-nhanes-2011-2012
#4
Melanie J Firestone, Jeannette M Beasley, Simona C Kwon, Jiyoung Ahn, Chau Trinh-Shevrin, Stella S Yi
OBJECTIVE: Asian Americans consume more sodium than other racial/ethnic groups. The purpose of this analysis was to describe major sources of sodium intake to inform sodium reduction initiatives. METHODS: Cross-sectional data on adults (aged >18 years) from the National Health and Nutrition Examination Survey (NHANES) 2011-2012 with one 24-hour dietary recall were analyzed (n=5,076). Population proportions were calculated from "What We Eat in America" (WWEIA) food categories...
2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/28811014/assessing-need-for-pharmacist-involvement-to-improve-care-coordination-for-patients-on-lai-antipsychotics-transitioning-from-hospital-to-home-a-work-system-approach
#5
Olufunmilola Abraham, Michelle N Myers, Amanda L Brothers, Jamie Montgomery, Bryan A Norman, Tanya Fabian
BACKGROUND: The use of Long-Acting Injectable (LAI) antipsychotic medications has increased for patients with Serious Mental Illness (SMI). Care coordination for this population is complex, and pharmacist involvement may improve and support long-term medication adherence and patient outcomes. OBJECTIVES: (1) Examine pharmacists' role in addressing care coordination and adherence challenges for patients taking Long-Acting Injectable (LAI) antipsychotics; and (2) explore patients' medication use experiences with LAI antipsychotics and educational needs...
September 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28810897/cost-of-hospitalization-for-childbirth-in-india-how-equitable-it-is-in-the-post-nrhm-era
#6
Jaya Prasad Tripathy, Hemant D Shewade, Sanskruti Mishra, A M V Kumar, A D Harries
BACKGROUND AND OBJECTIVE: Information on out-of-pocket (OOP) expenditure during childbirth in public and private health facilities in India is needed to make rational decisions for improving affordability to maternal care services. We undertook this study to evaluate the OOP expenditure due to hospitalization from childbirth and its impact on households. METHODS: This is a secondary data analysis of a nationwide household survey by the National Sample Survey Organization in 2014...
August 15, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28810022/characteristics-of-clinical-studies-used-for-us-food-and-drug-administration-approval-of-high-risk-medical-device-supplements
#7
Sarah Y Zheng, Sanket S Dhruva, Rita F Redberg
Importance: High-risk medical devices often undergo modifications, which are approved by the US Food and Drug Administration (FDA) through various kinds of premarket approval (PMA) supplements. There have been multiple high-profile recalls of devices approved as PMA supplements. Objective: To characterize the quality of the clinical studies and data (strength of evidence) used to support FDA approval of panel-track supplements (a type of PMA supplement pathway that is used for significant changes in a device or indication for use and always requires clinical data)...
August 15, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28809871/-recall-system-for-vaccinations-in-preschool-children-in-a-local-health-unit-in-rome-italy
#8
Aldo Marsico, Cinzia Roscetti, Angelo Fraioli, Chiara Grecuccio, Alessio Cecili, Laura Zaratti, Elisabetta Franco
In Italy, in this period, much attention is dedicated to reach adequate vaccination coverage in children and adolescents. In this study, Vaccination Registry was checked in a Local Health Unit in Rome, Italy, to identify children born in 2007 and 2008 who had not completed the vaccination schedule. Coverage for booster doses of measles, mumps, rubella and for diphtheria, tetanus, pertussis and polio vaccines in the 2213 children was around 70%. A reminder letter was send to parents of the 661 incompletely immunized children and, if they did not reply, a phone call was made when the phone number was available...
May 2017: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/28809751/influence-of-topical-iodine-containing-antiseptics-used-during-delivery-on-recall-rate-of-congenital-hypothyroidism-screening-program
#9
Majid Valizadeh, Farzaneh Moezzi, Zohreh Khavassi, Mohammad Movahedinia, Seideh Mazloomzadeh, Ladan Mehran
BACKGROUND: The proportion of newborns recalled during neonatal screening programs for congenital hypothyroidism (CH) varies substantially by country and may be higher in settings where povodine iodine (PVP-I) is used during delivery. We assessed this hypothesis by substituting PVP-I for chlorhexidine (CHL) and evaluated the reduction in the recall rate of the Irainian newborn screening program. METHODS: This study investigated 2282 neonates of mothers admitted to a local hospital for delivery between December 2012 and October 2013...
August 15, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28808921/volumetric-abnormalities-of-thalamic-subnuclei-in-medication-overuse-headache
#10
Zhiye Chen, Zhihua Jia, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma, Shengyuan Yu
BACKGROUND: The thalamus exerts a pivotal role in pain processing and cortical excitability control and a previous voxel-based morphometry study confirmed increased volume in bilateral thalamus in medication-overuse headache (MOH). The aim of this study is to investigate altered thalamic subnuclei volume in MOH compared with normal controls, and to evaluate the relationship of each thalamic subnuclei volume with the clinical variables. METHODS: High resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MR images were obtained from 27 patients with MOH and 27 normal controls (NC)...
August 14, 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28808792/using-natural-language-processing-of-free-text-radiology-reports-to-identify-type-1-modic-endplate-changes
#11
Hannu T Huhdanpaa, W Katherine Tan, Sean D Rundell, Pradeep Suri, Falgun H Chokshi, Bryan A Comstock, Patrick J Heagerty, Kathryn T James, Andrew L Avins, Srdjan S Nedeljkovic, David R Nerenz, David F Kallmes, Patrick H Luetmer, Karen J Sherman, Nancy L Organ, Brent Griffith, Curtis P Langlotz, David Carrell, Saeed Hassanpour, Jeffrey G Jarvik
Electronic medical record (EMR) systems provide easy access to radiology reports and offer great potential to support quality improvement efforts and clinical research. Harnessing the full potential of the EMR requires scalable approaches such as natural language processing (NLP) to convert text into variables used for evaluation or analysis. Our goal was to determine the feasibility of using NLP to identify patients with Type 1 Modic endplate changes using clinical reports of magnetic resonance (MR) imaging examinations of the spine...
August 14, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28807893/optimizing-the-use-of-electronic-health-records-to-identify-high-risk-psychosocial-determinants-of-health
#12
Nicolas Michel Oreskovic, Jennifer Maniates, Jeffrey Weilburg, Garry Choy
BACKGROUND: Care coordination programs have traditionally focused on medically complex patients, identifying patients that qualify by analyzing formatted clinical data and claims data. However, not all clinically relevant data reside in claims and formatted data. Recently, there has been increasing interest in including patients with complex psychosocial determinants of health in care coordination programs. Psychosocial risk factors, including social determinants of health, mental health disorders, and substance abuse disorders, are less amenable to rapid and systematic data analyses, as these data are often not collected or stored as formatted data, and due to US Health Insurance Portability and Accountability Act (HIPAA) regulations are often not available as claims data...
August 14, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/28807891/a-collaborative-approach-to-identifying-social-media-markers-of-schizophrenia-by-employing-machine-learning-and-clinical-appraisals
#13
Michael L Birnbaum, Sindhu Kiranmai Ernala, Asra F Rizvi, Munmun De Choudhury, John M Kane
BACKGROUND: Linguistic analysis of publicly available Twitter feeds have achieved success in differentiating individuals who self-disclose online as having schizophrenia from healthy controls. To date, limited efforts have included expert input to evaluate the authenticity of diagnostic self-disclosures. OBJECTIVE: This study aims to move from noisy self-reports of schizophrenia on social media to more accurate identification of diagnoses by exploring a human-machine partnered approach, wherein computational linguistic analysis of shared content is combined with clinical appraisals...
August 14, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28807795/d-cycloserine-facilitates-extinction-learning-and-enhances-extinction-related-brain-activation
#14
Anne Klass, Benjamin Glaubitz, Martin Tegenthoff, Silke Lissek
Extinction learning is modulated by N-methyl D-aspartate receptors (NMDAR) particularly in prefrontal and hippocampal brain regions. The use of of NMDA agonists in exposure therapy of anxiety disorders has been investigated in various patient groups. Behavioral results showed beneficial effects of pre-learning administration of the partial NMDAR agonist D-Cycloserine (DCS) on therapy success. However, the impact of DCS upon non-fear-related contextual extinction, and associated recruitment of extinction-relevant brain regions is as yet unknown...
August 11, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28807493/homocysteine-and-cognitive-function-in-parkinson-s-disease
#15
Nicole Licking, Charles Murchison, Brenna Cholerton, Cyrus P Zabetian, Shu-Ching Hu, Thomas J Montine, Amie L Peterson-Hiller, Kathryn A Chung, Karen Edwards, James B Leverenz, Joseph F Quinn
INTRODUCTION: Increased plasma homocysteine (HC) is a risk factor for dementia in the general population. Levodopa therapy causes increased plasma HC, but it remains unclear whether elevated plasma HC is associated with cognitive impairment in Parkinson's disease (PD). METHODS: The study population includes all participants in the Pacific Northwest Udall Center (PANUC) Clinical cohort at the time of the study, consisting of 294 individuals with PD who had a standardized neuropsychological assessment and plasma collection for HC measurement...
August 9, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28806418/seasonality-affects-dietary-diversity-of-school-age-children-in-northern-ghana
#16
Abdul-Razak Abizari, Fusta Azupogo, Miwako Nagasu, Noortje Creemers, Inge D Brouwer
BACKGROUND AND OBJECTIVES: Dietary diversity score (DDS) is relatively easy to measure and is shown to be a very useful indicator of the probability of adequate micronutrient intake. Dietary diversity, however, is usually assessed during a single period and little is known about the effect of seasonality on it. This study investigates whether dietary diversity is influenced by seasonality. METHODS: Two cross-sectional surveys were conducted in two different seasons-dry season (October 2010) and rainy season (May 2011) among the same school-age children (SAC) in two rural schools in northern Ghana...
2017: PloS One
https://www.readbyqxmd.com/read/28806193/speech-perception-in-noise-and-listening-effort-of-older-adults-with-nonlinear-frequency-compression-hearing-aids
#17
James Shehorn, Nicole Marrone, Thomas Muller
OBJECTIVES: The purpose of this laboratory-based study was to compare the efficacy of two hearing aid fittings with and without nonlinear frequency compression, implemented within commercially available hearing aids. Previous research regarding the utility of nonlinear frequency compression has revealed conflicting results for speech recognition, marked by high individual variability. Individual differences in auditory function and cognitive abilities, specifically hearing loss slope and working memory, may contribute to aided performance...
August 10, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28806171/the-importance-of-remembering
#18
Eve Marder
Creativity in science requires the ability to recall information and data, and will suffer if we rely too much on technology to remember things for us.
August 14, 2017: ELife
https://www.readbyqxmd.com/read/28805734/grain-foods-are-contributors-of-nutrient-density-for-american-adults-and-help-close-nutrient-recommendation-gaps-data-from-the-national-health-and-nutrition-examination-survey-2009-2012
#19
Yanni Papanikolaou, Victor L Fulgoni
The 2015-2020 Dietary Guidelines for Americans (2015-2020 DGA) maintains recommendations for increased consumption of whole grains while limiting intake of enriched/refined grains. A variety of enriched grains are sources of several shortfall nutrients identified by 2015-2020 DGA, including dietary fiber, folate, iron, and magnesium. The purpose of this study was to determine food sources of energy and nutrients for free-living U.S. adults using data from the National Health and Nutrition Examination Survey, 2009-2012...
August 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28805672/challenges-in-estimating-vaccine-coverage-in-refugee-and-displaced-populations-results-from-household-surveys-in-jordan-and-lebanon
#20
Timothy Roberton, William Weiss, Shannon Doocy
Ensuring the sustained immunization of displaced persons is a key objective in humanitarian emergencies. Typically, humanitarian actors measure coverage of single vaccines following an immunization campaign; few measure routine coverage of all vaccines. We undertook household surveys of Syrian refugees in Jordan and Lebanon, outside of camps, using a mix of random and respondent-driven sampling, to measure coverage of all vaccinations included in the host country's vaccine schedule. We analyzed the results with a critical eye to data limitations and implications for similar studies...
August 12, 2017: Vaccines
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