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https://www.readbyqxmd.com/read/29228271/litpathexplorer-a-confidence-based-visual-text-analytics-tool-for-exploring-literature-enriched-pathway-models
#1
Axel J Soto, Chrysoula Zerva, Riza Batista-Navarro, Sophia Ananiadou
Motivation: Pathway models are valuable resources that help us understand the various mechanisms underpinning complex biological processes. Their curation is typically carried out through manual inspection of published scientific literature to find information relevant to a model, which is a laborious and knowledge-intensive task. Furthermore, models curated manually cannot be easily updated and maintained with new evidence extracted from the literature without automated support. Results: We have developed LitPathExplorer, a visual text analytics tool that integrates advanced text mining, semi-supervised learning and interactive visualization, to facilitate the exploration and analysis of pathway models using statements (i...
December 8, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29228051/white-blood-cell-differential-count-of-maturation-stages-in-bone-marrow-smear-using-dual-stage-convolutional-neural-networks
#2
Jin Woo Choi, Yunseo Ku, Byeong Wook Yoo, Jung-Ah Kim, Dong Soon Lee, Young Jun Chai, Hyoun-Joong Kong, Hee Chan Kim
The white blood cell differential count of the bone marrow provides information concerning the distribution of immature and mature cells within maturation stages. The results of such examinations are important for the diagnosis of various diseases and for follow-up care after chemotherapy. However, manual, labor-intensive methods to determine the differential count lead to inter- and intra-variations among the results obtained by hematologists. Therefore, an automated system to conduct the white blood cell differential count is highly desirable, but several difficulties hinder progress...
2017: PloS One
https://www.readbyqxmd.com/read/29227880/the-relationship-between-australian-harm-minimisation-alcohol-education-and-student-uptake-consumption-and-harm
#3
Richard Midford, Leanne Lester, Tahlia Williams, Victoria White
BACKGROUND: Alcohol use by young people is a public health concern in Australia because of the disproportionate harm they experience. Accordingly, governments have sought to protect young people, with school identified as an appropriate site for drug, including alcohol, prevention through education. School-based drug education programmes, however, have not been particularly effective, and even when individual programs report prevention benefits they can be criticised for being developed and evaluated by the same group...
December 8, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29227736/older-patients-recall-of-online-cancer-information-do-ability-and-motivation-matter-more-than-chronological-age
#4
Nadine Bol, Ellen M A Smets, Jacobus A Burgers, Suzy M Samii, Hanneke C J M De Haes, Julia C M Van Weert
This study proposes and tests a model to provide a more comprehensive understanding of the contribution of chronological age versus age-related ability and motivation factors in explaining recall of online cancer information among older patients (n = 197). Results revealed that recall is not a matter of chronological age per se, but rather a matter of ability and motivation. Age-related ability and motivation factors explained 37.9% of the variance in recall. Health literacy, involvement with the webpage, and satisfaction with the emotional support were positively associated with recall...
December 11, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/29226861/neuroanatomical-comparison-of-the-word-and-picture-versions-of-the-free-and-cued-selective-reminding-test-in-alzheimer-s-disease
#5
Andrea Slachevsky, Paulo Barraza, Michael Hornberger, Carlos Muñoz-Neira, Emma Flanagan, Fernando Henríquez, Eduardo Bravo, Mauricio Farías, Carolina Delgado
Episodic memory tests with cued recall, such as the Free and Cued Selective Reminding Test (FCSRT), allow for the delineation of hippocampal and prefrontal atrophy contributions to memory performance in Alzheimer's disease (AD). Both Word and Picture versions of the test exist but show different profiles, with the Picture version usually scoring higher across different cohorts. One possible explanation for this divergent performance between the different modality versions of the test might be that they rely on different sets of neural correlates...
December 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29226769/working-memory-capacity-and-the-spacing-effect-in-cued-recall
#6
Peter F Delaney, Namrata R Godbole, Latasha R Holden, Yoojin Chang
Spacing repetitions typically improves memory (the spacing effect). In three cued recall experiments, we explored the relationship between working memory capacity and the spacing effect. People with higher working memory capacity are more accurate on memory tasks that require retrieval relative to people with lower working memory capacity. The experiments used different retention intervals and lags between repetitions, but were otherwise similar. Working memory capacity and spacing of repetitions both improved memory in most of conditions, but they did not interact, suggesting additive effects...
December 11, 2017: Memory
https://www.readbyqxmd.com/read/29226513/consolidation-of-vocabulary-is-associated-with-sleep-in-typically-developing-children-but-not-in-children-with-dyslexia
#7
Faye R H Smith, M Gareth Gaskell, Anna R Weighall, Meesha Warmington, Alexander M Reid, Lisa M Henderson
Sleep is known to play an active role in consolidating new vocabulary in adults; however, the mechanisms by which sleep promotes vocabulary consolidation in childhood are less well understood. Furthermore, there has been no investigation into whether previously reported differences in sleep architecture might account for variability in vocabulary consolidation in children with dyslexia. Twenty-three children with dyslexia and 29 age-matched typically developing peers were exposed to 16 novel spoken words. Typically developing children showed overnight improvements in novel word recall; the size of the improvement correlated positively with slow wave activity, similar to previous findings with adults...
December 11, 2017: Developmental Science
https://www.readbyqxmd.com/read/29226355/changes-in-verbal-and-visuospatial-working-memory-from-grade-1-to-grade-3-of-primary-school-population-longitudinal-study
#8
E Nicolaou, J Quach, J Lum, G Roberts, M Spencer-Smith, S Gathercole, P J Anderson, F K Mensah, M Wake
BACKGROUND: Adaptive working memory training is being implemented without an adequate understanding of developmental trajectories of working memory. We aimed to quantify from Grade 1 to Grade 3 of primary school (1) changes in verbal and visuospatial working memory and (2) whether low verbal and visuospatial working memory in Grade 1 predicts low working memory in Grade 3. METHOD: The study design includes a population-based longitudinal study of 1,802 children (66% uptake from all 2,747 Grade 1 students) at 44 randomly selected primary schools in Melbourne, Australia...
December 11, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/29226183/in-vitro-homeostatic-proliferation-of-human-cd8-t-cells
#9
Hossam A Abdelsamed, Caitlin C Zebley, Ben Youngblood
Long-lived T-cell-mediated immunity requires persistence of memory T cells in an antigen-free environment while also maintaining a heightened capacity to recall effector functions. Such antigen-independent homeostatic proliferation is mediated in part by the common gamma-chain cytokines IL-7 and IL-15. To further explore the mechanisms governing maintenance of effector functions in long-lived memory T cells during antigen-independent proliferation, human naïve and memory CD8 T cells can be sorted from peripheral blood mononuclear cells (PBMCs), labeled with the proliferation-tracking dye carboxyfluorescein succinimidyl ester (CFSE), and then purified based on their levels of cell division...
November 20, 2017: Bio-protocol
https://www.readbyqxmd.com/read/29225083/computer-aided-diagnosis-for-identifying-and-delineating-early-gastric-cancers-in-magnifying-narrow-band-images
#10
Takashi Kanesaka, Tsung-Chun Lee, Noriya Uedo, Kun-Pei Lin, Huai-Zhe Chen, Ji-Yuh Lee, Hsiu-Po Wang, Hsuan-Ting Chang
BACKGROUND AND AIMS: Magnifying narrow-band imaging (M-NBI) is important in the diagnosis of early gastric cancers (EGCs), but requires expertise to master. We developed a computer-aided diagnosis (CADx) system to assist endoscopists in identifying and delineating EGCs. METHODS: We retrospectively collected and randomly selected 66 EGC M-NBI images and 60 non-cancer M-NBI images into a training set, and 61 EGC M-NBI images and 20 non-cancer M-NBI images into a test set...
December 7, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29224926/fully-automated-detection-and-quantification-of-macular-fluid-in-oct-using-deep-learning
#11
Thomas Schlegl, Sebastian M Waldstein, Hrvoje Bogunovic, Franz Endstraßer, Amir Sadeghipour, Ana-Maria Philip, Dominika Podkowinski, Bianca S Gerendas, Georg Langs, Ursula Schmidt-Erfurth
PURPOSE: Development and validation of a fully automated method to detect and quantify macular fluid in conventional OCT images. DESIGN: Development of a diagnostic modality. PARTICIPANTS: The clinical dataset for fluid detection consisted of 1200 OCT volumes of patients with neovascular age-related macular degeneration (AMD, n = 400), diabetic macular edema (DME, n = 400), or retinal vein occlusion (RVO, n = 400) acquired with Zeiss Cirrus (Carl Zeiss Meditec, Dublin, CA) (n = 600) or Heidelberg Spectralis (Heidelberg Engineering, Heidelberg, Germany) (n = 600) OCT devices...
December 8, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29223768/verbal-learning-and-hippocampal-dysfunction-in-schizophrenia-a-meta-analysis
#12
REVIEW
Mathilde Antoniades, Tabea Schoelera, Joaquim Radua, Isabel Valli, Paul Allen, Matthew J Kempton, Philip McGuire
This meta-analysis summarizes research examining whether deficits in verbal learning are related to bilateral hippocampal volume reductions in patients with or at risk for schizophrenia and in healthy controls. 17 studies with 755 patients with schizophrenia (SCZ), 232 Genetic High Risk (GHR) subjects and 914 healthy controls (HC) were included. Pooled correlation coefficients were calculated between hemisphere (left, right or total) and type of recall (immediate or delayed) for each diagnostic group individually (SCZ, GHR and HC)...
December 6, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29223480/enlisting-the-willing-a-study-of-healthcare-professional-initiated-and-opt-in-biobanking-consent-reveals-improvement-opportunities-throughout-the-registration-process
#13
Elizabeth A Fradgley, Shu Er Chong, Martine E Cox, Christine L Paul, Craig Gedye
Biobanking consent processes should accord with patients' preferences and be offered in a consistent and systematic manner. However, these aims can be difficult to achieve under healthcare professionals' (HCPs) time-constrained workflows, resulting in low participation rates. This current perspective provides a brief overview of HCP involvement in consent and reports new data on participant attrition at each step of the biobanking consent process as experienced by 113 patients at an Australian tertiary cancer centre...
December 7, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29223440/outcomes-of-cardiac-pacing-in-adult-patients-after-a-fontan-operation
#14
Alexander C Egbe, Geoffery D Huntley, Heidi M Connolly, Naser M Ammash, Abhishek J Deshmukh, Arooj R Khan, Sameh M Said, Emmanuel Akintoye, Carole A Warnes, Suraj Kapa
BACKGROUND: Cardiac pacing can be challenging after a Fontan operation, and limited data exist regarding pacing in adult Fontan patients. The objectives of our study were to determine risk factors for pacing and occurrence of device-related complications (DRCs) and pacemaker reinterventions. METHODS: We performed a retrospective review of Fontan patients from 1994 through 2014. We defined DRCs as lead failure, lead recall, cardiac perforation, lead thrombus/vegetation, or device-related infection, and cardiovascular adverse events (CAEs) as venous thrombosis, stroke, death, or heart transplant...
December 2017: American Heart Journal
https://www.readbyqxmd.com/read/29223397/-borneol-suppresses-conditioned-fear-recall-and-anxiety-like-behaviors-in-mice
#15
Bo Cao, Huan-Yu Ni, Jun Li, Ying Zhou, Xin-Lan Bian, Yan Tao, Cheng-Yun Cai, Cheng Qin, Hai-Yin Wu, Lei Chang, Chun-Xia Luo, Dong-Ya Zhu
Fear- and anxiety-related psychiatric disorders have been one of the major chronic diseases afflicting patients for decades, and new compounds for treating such disorders remain to be developed. (+)-Borneol, a bicyclic monoterpene found in several species of Artemisia and Dipterocarpaceae, is widely used for anxiety, pain and anesthesia in Chinese medicine. Meanwhile, it can potentiate GABA (γ-aminobutyric acid) activity directly in recombinant GABAA receptors. The present study was to investigate the effects of (+)-Borneol on both contextual and cued fear recall...
December 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29223200/emotions-as-proximal-causes-of-word-of-mouth-a-nonlinear-approach
#16
Rita Rueff Lopes, José Navarro, Ana Junca Silva
Service research tends to operationalize word of mouth (WOM) behavior as one of the many responses to service satisfaction. In this sense, little is known about its antecedents or moderators. The objective of this study was to investigate the role of customers' emotions during service experiences on WOM, applying nonlinear techniques and exploring the moderating role of customers' propensity for emotional contagion. Using the critical incidents technique, 122 customers recalled significant service experiences and the emotions they aroused, and reported if they shared said experiences with other individuals...
January 2018: Nonlinear Dynamics, Psychology, and Life Sciences
https://www.readbyqxmd.com/read/29222902/fruit-and-vegetable-intake-of-korean-children-and-adolescents-according-to-cooking-location-and-daily-meal-study-based-on-2010-and-2011-korea-national-health-and-nutrition-examination-survey-data
#17
Yong-Suk Kwon, Yangsuk Kim
BACKGROUND AND OBJECTIVES: This study analyzed the intake of fruits and vegetables by cooking location and daily meals for Korean children and adolescents. METHODS AND STUDY DESIGN: For this study, 2,538 Korean children and adolescents aged 7-18 years, who participated in the 2010 and 2011 Korea National Health and Nutrition Examination Survey dietary intake survey (24-hour recall methods), were sampled. RESULTS: The total unsalted fruit and vegetable intake for all subjects was 300 g (aged 7-12 years, 280 g; aged 13-18 years, 316 g)...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222901/association-of-energy-intake-and-physical-activity-with-overweight-among-indonesian-children-6-12-years-of-age
#18
Heryudarini Harahap, Sandjaja Sandjaja, Moesijanti Soekatri, Ilse Khouw, Paul Deurenberg
BACKGROUND AND OBJECTIVES: Indonesia is currently facing double burden malnutrition in children. As overweight and obesity are due to a disturbed energy balance, this study aimed to assess the association of total energy intake and physical activity with the prevalence of overweight among Indonesian children. METHODS AND STUDY DESIGN: The data used for this analysis were from 1143 children, 6-12 years old, that participated in the South East Asian Nutrition Survey (SEANUTS)...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222880/consumption-and-sources-of-added-sugar-in-indonesia-a-review
#19
Atmarita, Nelis Imanningsih, Abas B Jahari, Ir Dewi Permaesih, Pauline Chan, Maria Sofia Amarra
BACKGROUND AND OBJECTIVES: The present report summarized the best available evidence regarding consumption level and sources of free or added sugars in Indonesia. METHODS AND STUDY DESIGN: Information was extracted from food balance sheets, household expenditure surveys, nutrition surveys, published studies, unpublished theses/ dissertations, and government reports. RESULTS: A total of 18 references were obtained, showing varying results. Indonesia's national surveys suggested intakes of sugar below 50 grams per day or below 10% of energy intake...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222722/binaural-auditory-beats-affect-long-term-memory
#20
Miguel Garcia-Argibay, Miguel A Santed, José M Reales
The presentation of two pure tones to each ear separately with a slight difference in their frequency results in the perception of a single tone that fluctuates in amplitude at a frequency that equals the difference of interaural frequencies. This perceptual phenomenon is known as binaural auditory beats, and it is thought to entrain electrocortical activity and enhance cognition functions such as attention and memory. The aim of this study was to determine the effect of binaural auditory beats on long-term memory...
December 8, 2017: Psychological Research
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