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https://www.readbyqxmd.com/read/29913481/deficiency-of-long-chain-polyunsaturated-fatty-acids-in-phenylketonuria-a-cross-sectional-study
#1
Sławomira Drzymała-Czyż, Łukasz Kałużny, Patrycja Krzyżanowska-Jankowska, Dariusz Walkowiak, Renata Mozrzymas, Jarosław Walkowiak
The etiology of altered blood fatty acid (FA) profile in phenylketonuria (PKU) is understood only partially. We aimed to determine whether FAs deficiency is dependent on the diet or metabolic disturbances. The study comprised 40 PKU patients (20 female, 20 male; aged 11 to 35 years; 12 children and 28 adults) and 40 healthy subjects (HS; 20 female, 20 male, aged 18 to 33 years). We assessed the profile of FAs (gas chromatography/mass spectrometry) and analyzed the 72-hour dietary recalls. The amount of C14:0, C16:0 and C16:1n-7, C18:1n-9 did not differ between the analyzed groups...
2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29913227/effects-of-bright-light-exposure-on-human-fear-conditioning-extinction-and-associated-prefrontal-activation
#2
Takuya Yoshiike, Motoyasu Honma, Naoto Yamada, Yoshiharu Kim, Kenichi Kuriyama
Bright light (BL) not only regulates human emotion and circadian physiology but can also directly modulate emotional memories. Impaired fear extinction and enhanced fear acquisition and consolidation are hallmarks of fear-circuitry disorders; thus, we tested whether BL facilitates fear extinction and inhibits fear acquisition. We randomly exposed 29 healthy humans to high- (9000 lx) or low-intensity light (<500 lx) for 15 min, near the nadir of the phase response to light, in a single-blind manner...
June 15, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29913175/implementation-of-an-urogynecology-specific-enhanced-recovery-after-surgery-eras-pathway
#3
Charelle M Carter-Brooks, Angela L Du, Kristine M Ruppert, Anna L Romanova, Halina M Zyczynski
OBJECTIVES: ERAS protocols were developed for colorectal surgery to hasten post-op recovery. Variations of the protocol are being adopted for gynecologic procedures despite limited population and procedure-specific outcome data. Our objective was to evaluate if implementation of an ERAS pathway would facilitate reduced length of admission in an urogynecology population. MATERIALS AND METHODS: In this retrospective analysis of patients undergoing pelvic floor reconstructive surgery by 7 female pelvic medicine and reconstructive surgeons we compared same day discharge, length of admission and post-op complications before and after implementation of an ERAS pathway at a tertiary-care hospital...
June 15, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29913096/what-does-it-take-to-graduate-a-qualitative-exploration-of-the-perceptions-of-successful-physiotherapy-graduates-from-one-university-in-the-uk
#4
Elizabeth Cassidy, Meriel Norris, Annabel Williams
Little is known about the complex factors that underpin persistence and success for preregistration physiotherapy students. This article presents findings from a qualitative study which explored the perceptions of eight recent graduates from one UK university about their experiences of their physiotherapy undergraduate degree program, and what they considered important in their success. Data were collected via one-to-one, semi-structured interviews. An in-depth thematic analysis was undertaken from which three overarching themes were inferred...
June 18, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29912935/egocentric-networks-and-physical-activity-outcomes-in-latinas
#5
Becky Marquez, Greg Norman, James Fowler, Kim Gans, Bess Marcus
OBJECTIVE: Despite data linking the social environment to physical inactivity in Latinas, research on social network predictors of physical activity (PA) is limited. This study examined social network predictors of PA change in Latinas. METHODS: Egocentric network data were collected from 102 adult Latinas (egos) participating in a randomized controlled PA intervention trial for underactive women. Moderate-to-vigorous PA (MVPA) was measured in minutes per week using the 7-Day PA Recall Interview and accelerometers at baseline and 12 months...
2018: PloS One
https://www.readbyqxmd.com/read/29912268/diet-quality-indices-and-leukocyte-telomere-length-among-healthy-us-adults-data-from-the-national-health-and-nutrition-examination-surveys-nhanes-1999-2002
#6
Cindy W Leung, Teresa T Fung, Claire T McEvoy, Jue Lin, Elissa S Epel
Aging is the biggest risk factor for the development of chronic diseases. Telomere length may represent one important mechanism by which dietary intake influences age-related diseases; however, it is unknown which diet pattern is most strongly related to telomere length. We compared the relations between four evidence-based diet quality indices and leukocyte telomere length in a nationally representative sample of healthy adults, and the extent to which these associations differ between men and women. Data came from 4,758 adults, aged 20-65 years, with no prior diagnosis of major chronic disease, from the 1999-2002 National Health and Nutrition Examination Surveys (NHANES)...
June 15, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29911881/who-s-to-blame-dissimilarity-as-a-cue-in-moral-judgments-of-observed-ostracism-episodes
#7
Selma Carolin Rudert, Daniela Sutter, Veronique Charlotte Corrodi, Rainer Greifeneder
When observing an ostracism episode, observers may wish to know whether ostracism is justified or not. If ostracism appears unjustified, observers will likely blame the sources and sympathize with the target; if it appears justified, observers will likely blame and devalue the target. Here we introduce the "social dissimilarity rule," which holds that observers base their moral judgments on dissimilarities between the members of the observed group. In five studies, participants either recalled observed ostracism episodes or observed group interactions in which one group member was ostracized (e...
July 2018: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/29911635/migraine-co-existing-tension-type-headache-and-neck-pain-validation-of-questionnaires
#8
Lotte Skytte Krøll, Catharina Sjödahl Hammarlund, Rigmor Højland Jensen, Gunvor Gard
Aabstract Background and aim Migraine often includes co-existing tension-type headache (TTH) and neck pain (NP). Multiple headache questionnaires assessing headache impact have beendescribed previously; however, none of the existing questionnaires have been designed to cover migraine with co-existing TTH and NP. Therefore a new questionnaire was developed to measure these co-morbidities. The aim was to determine face and content validity of the newly developed questionnaire, "Impact of Migraine, Tension-Type Headache and Neck Pain" (impact M-TTH-NP) and to determine face and content validity of the International Physical Activity Questionnaire (IPAQ short form), Migraine-Specific Quality of Life Questionnaire (MSQ v...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911045/congenital-hypothyroidism-screening-in-term-neonates-using-umbilical-cord-blood-tsh-values
#9
Ravi Bhatia, Dinesh Rajwaniya
Congenital hypothyroidism remains one of the most common preventable causes of mental retardation among children. Screening for congenital hypothyroidism remains one of the most cost-effective tools to prevent mental retardation in the population. Umbilical cord blood thyroid-stimulating hormone (TSH) levels remain an attractive and a practical step for screening for congenital hypothyroidism. The aims of this study were as follows: (1) to find normative values of cord blood TSH for the study group and (2) to use cord blood TSH levels as a marker for screening of congenital hypothyroidism...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29911039/determinants-of-vitamin-d-status-in-indian-school-children
#10
Rubina Mandlik, Neha Kajale, Veena Ekbote, Vivek Patwardhan, Vaman Khadilkar, Shashi Chiplonkar, Anuradha Khadilkar
Introduction: Due to the high prevalence of Vitamin D deficiency in spite of abundant sunshine and scarcity of studies investigating Vitamin D status in Indian children from rural and semirural areas, the objectives of this cross-sectional study were to: (1) assess the Vitamin D status of school-children in a semi-rural setting and (2) identify the determinants of Vitamin D status in these children. Materials and Methods: Data collected included anthropometric measurements (height and weight), body composition, three-one-day dietary recall method, demographic data, and sunlight exposure...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29910688/recalling-cohnheim-s-theory-papillary-renal-cell-tumor-as-a-model-of-tumorigenesis-from-impaired-embryonal-differentiation-to-malignant-tumors-in-adults
#11
Daniel Banyai, Donat P Sarlos, Anetta Nagy, Gyula Kovacs
We have suggested that papillary renal cell tumor (PRCT) of the kidney arises from nephrogenic rest-like lesions. To approve our hypothesis, we worked up 14 kidneys bearing papillary and 14 ones with conventional renal cell carcinoma (CRCC) histologically and found 42 papillary lesions in average per kidney bearing PRCT. PRCTs are characterized by loss of the Y chromosome and trisomy of chromosomes 7 and 17. The MET and HNF1B are localized to chromosome 7q31 and 17q21 and are frequently amplified in PRCT. We have analyzed the expression of the mutant MET in hereditary PRCTs and precursor lesions and found duplication and expression of the mutated allele...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29910128/miming-neurological-syndromes-improves-medical-student-s-long-term-retention-and-delayed-recall-of-neurology
#12
Emmanuel Roze, Yulia Worbe, Céline Louapre, Aurélie Méneret, Cécile Delorme, Eavan McGovern, Marta Ruiz, Jean Capron, Raphaël Le Bouc, Stéphane Epelbaum, Sonia Alamowitch, Alexandre Duguet, Marie-Christine Renaud, Olivier Palombi, Tamara M Pringsheim, Constance Flamand-Roze, Olivier Steichen
Basic examination and diagnostic skills in neurology are important for every graduating medical student. However, a majority of medical students consider neurology as complex and difficult to master. We evaluate the impact a learner-friendly, innovative simulation-based training programme has on long-term retention and delayed recall of neurological semiology amongst third-year medical students from the University Pierre et Marie Curie in Paris, France. The 2013 class received standard teaching in neurological semiology...
June 7, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29910118/rct-of-centralized-vaccine-reminder-recall-for-adults
#13
Laura P Hurley, Brenda Beaty, Steven Lockhart, Dennis Gurfinkel, Kristin Breslin, Miriam Dickinson, Melanie D Whittington, Heather Roth, Allison Kempe
INTRODUCTION: A proven, but underutilized, method to increase current low vaccination rates is reminder/recall. Centralized reminder/recall using an Immunization Information System reduces the burden of an individual practice conducting reminder/recall. The objectives were to assess the effectiveness of centralized vaccine reminder/recall on improving adult vaccination rates using Colorado's Immunization Information System. STUDY DESIGN: This study is a pragmatic RCT...
June 14, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29909870/a-modeling-study-of-the-cost-effectiveness-of-a-risk-stratified-surveillance-program-for-melanoma-in-the-united-kingdom
#14
Edward C F Wilson, Juliet A Usher-Smith, Jon Emery, Pippa Corrie, Fiona M Walter
BACKGROUND: Population-wide screening for melanoma is unlikely to be cost-effective. Nevertheless, targeted surveillance of high-risk individuals may be. OBJECTIVES: To estimate the cost-effectiveness of various surveillance strategies in the UK population, stratified by risk using a simple self-assessment tool scoring between 0 and 67. METHODS: A decision model comparing alternative surveillance policies from the perspective of the UK National Health Service over 30 years was developed...
June 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29909868/core-items-for-a-standardized-resource-use-measure-expert-delphi-consensus-survey
#15
Joanna C Thorn, Sara T Brookes, Colin Ridyard, Ruth Riley, Dyfrig A Hughes, Sarah Wordsworth, Sian M Noble, Gail Thornton, William Hollingworth
BACKGROUND: Resource use measurement by patient recall is characterized by inconsistent methods and a lack of validation. A validated standardized resource use measure could increase data quality, improve comparability between studies, and reduce research burden. OBJECTIVES: To identify a minimum set of core resource use items that should be included in a standardized adult instrument for UK health economic evaluation from a provider perspective. METHODS: Health economists with experience of UK-based economic evaluations were recruited to participate in an electronic Delphi survey...
June 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29909813/reduced-plasma-concentration-of-branched-chain-amino-acids-in-sarcopenic-older-subjects-a-cross-sectional-study
#16
Inger Ottestad, Stine M Ulven, Linn K L Øyri, Kristin S Sandvei, Gyrd O Gjevestad, Asta Bye, Navida A Sheikh, Anne S Biong, Lene F Andersen, Kirsten B Holven
Branched-chain amino acids (BCAA) are essential amino acids that are necessary for muscle mass maintenance. Little is known about the plasma concentrations of BCAA and the protein intake in relation to sarcopenia. We aimed to compare the non-fasting plasma concentrations of the BCAA and the dietary protein intake between sarcopenic and non-sarcopenic older adults. Norwegian older home-dwelling adults (≥70 years) were invited to a cross-sectional study with no other exclusion criteria than age. Sarcopenic subjects were defined by the diagnostic criteria by the European Working Group on Sarcopenia in Older People...
June 18, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29908648/maternal-perceived-stress-during-pregnancy-increases-risk-for-low-neonatal-iron-at-delivery-and-depletion-of-storage-iron-at-one-year
#17
Danielle N Rendina, Sharon E Blohowiak, Christopher L Coe, Pamela J Kling
OBJECTIVE: To investigate the impact of maternal stress during pregnancy on newborn iron and stage 1 iron deficiency at 1 year of age. STUDY DESIGN: In total, 245 mothers and their newborn infants (52% male; 72% white) were recruited at the Meriter Hospital Birthing Center on the basis of known risk factors for iron deficiency. Umbilical cord blood hemoglobin and zinc protoporphyrin/heme (ZnPP/H) were determined to evaluate erythrocyte iron and plasma ferritin was determined to reflect storage iron...
June 14, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29908358/from-lexical-regularities-to-axiomatic-patterns-for-the-quality-assurance-of-biomedical-terminologies-and-ontologies
#18
Philip van Damme, Manuel Quesada-Martínez, Ronald Cornet, Jesualdo Tomás Fernández-Breis
Ontologies and terminologies have been identified as key resources for the achievement of semantic interoperability in biomedical domains. The development of ontologies is performed as a joint work by domain experts and knowledge engineers. The maintenance and auditing of these resources is also the responsibility of such experts, and this is usually a time-consuming, mostly manual task. Manual auditing is impractical and ineffective for most biomedical ontologies, especially for larger ones. An example is SNOMED CT, a key resource in many countries for codifying medical information...
June 13, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29908175/young-patients-with-sporadic-colorectal-adenomas-current-endoscopic-surveillance-practices-and-outcomes
#19
Jae Myung Cha, Danielle La Selva, Richard A Kozarek, Michael Gluck, Andrew Ross, Otto S Lin
BACKGROUND AND AIMS: For young individuals (<40) without strong family histories that would put them at risk for genetic colorectal cancer syndromes, it is unclear if national Multi-Society Task Force surveillance recommendations apply or if endoscopists follow these guideline recommendations when such patients are incidentally found to have adenoma(s) on colonoscopy. METHODS: We reviewed records on young (<40-year-old) patients, with either no family history or only a "moderate" family history (one first-degree family member with colorectal cancer at age ≥50), who were found to have neoplastic polyp(s) on their index colonoscopy...
June 13, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29907560/validation-of-a-natural-language-processing-algorithm-for-detecting-infectious-disease-symptoms-in-primary-care-electronic-medical-records-in-singapore
#20
Antony Hardjojo, Arunan Gunachandran, Long Pang, Mohammed Ridzwan Bin Abdullah, Win Wah, Joash Wen Chen Chong, Ee Hui Goh, Sok Huang Teo, Gilbert Lim, Mong Li Lee, Wynne Hsu, Vernon Lee, Mark I-Cheng Chen, Franco Wong, Jonathan Siung King Phang
BACKGROUND: Free-text clinical records provide a source of information that complements traditional disease surveillance. To electronically harness these records, they need to be transformed into codified fields by natural language processing algorithms. OBJECTIVE: The aim of this study was to develop, train, and validate Clinical History Extractor for Syndromic Surveillance (CHESS), an natural language processing algorithm to extract clinical information from free-text primary care records...
June 11, 2018: JMIR Medical Informatics
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