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https://www.readbyqxmd.com/read/28218307/effects-of-u0126-and-mk2206-on-cell-growth-and-re-growth-of-endometriotic-stromal-cells-grown-on-substrates-of-varying-stiffness
#1
Sachiko Matsuzaki, Jean-Luc Pouly, Michel Canis
Endometriosis is a common gynecological disorder responsible for infertility and pelvic pain. A complete cure for patients with endometriosis awaits new targets and strategies. Here we show that U0126 (a MEK inhibitor) and MK2206 (an AKT inhibitor) synergistically inhibit cell growth of deep endometriotic stromal cells (DES) grown on polyacrylamide gel substrates (PGS) of varying stiffness (2 or 30 kilopascal [kPa]) or plastic in vitro. No significant differences in cell proliferation were observed among DES, endometrial stromal cells of patients with endometriosis (EES) from the proliferative phase (P), EES-S (secretory phase) and EES-M (menstrual phase) compared to cells grown on a substrate of the same stiffness at both higher (U0126 [30 μM] and MK2206 [9 μM]) and lower (U0126 [15 μM] and MK2206 [4...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28217695/gut-microbiome-and-chronic-prostatitis-chronic-pelvic-pain-syndrome
#2
REVIEW
Hans C Arora, Charis Eng, Daniel A Shoskes
Analysis of the human microbiome continues to reveal new and previously unrealized associations between microbial dysbiosis and disease. Novel approaches to bacterial identification using culture-independent methods allow practitioners to discern the presence of alterations in the taxa and diversity of the microbiome and identify correlations with disease processes. While some of these diseases that have been extensively studied are well-defined in their etiology and treatment methods (colorectal cancer), others have provided much more significant challenges in both diagnosis and treatment...
January 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28216457/endometriosis-in-hydatid-cysts-of-morgagni-a-retrospective-cohort-study-of-another-atypical-manifestation-of-endometriosis
#3
Shweta Gupta, Jeffrey A Gavard, Elena Kraus, Patrick Yeung
OBJECTIVE: To report on the presence and rate of endometriosis in hydatid cysts of Morgagni found at the time of excision surgery for endometriosis, and to describe any association of endometriosis in hydatid cysts of Morgagni to preoperative or operative factors. DESIGN: Retrospective cohort study DESIGN: Classification: Canadian Task Force Classification Level II-2 evidence SETTING: Center for Endometriosis at Saint Louis University, a tertiary referral center for endometriosis PATIENTS: Women who underwent optimal excision surgery for suspected endometriosis due to chronic pelvic pain and/or infertility and who also had hydatid cysts of Morgagni removed at the time of surgery, when found...
February 16, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28212593/micrornas-and-endometriosis-distinguishing-drivers-from-passengers-in-disease-pathogenesis
#4
Warren B Nothnick
Endometriosis is a disease common in women of reproductive age, characterized by pelvic pain and infertility. Despite its prevalence, the factors and mechanisms which contribute to the development and survival of ectopic lesions remain uncertain. MicroRNAs (miRNAs) are small RNA molecules that regulate posttranscriptional gene regulation which have been proposed to contribute to the pathogenesis of many diseases including that of endometriosis. This review summarizes the results of initial studies describing differentially expressed miRNAs between endometriotic lesion tissue and eutopic endometrium...
February 17, 2017: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/28210025/vascular-lipoleiomyoma-of-the-uterus-an-unusual-case
#5
Vesna Chibisheva, Vesna Antovska, Milka Trajanova, Drage Dabeski, Rubens Jovanovic, Ivana Kijajova
INTRODUCTION: Uterine lipoleiomyomas are a rare type of uterine myomas, which have been seldom diagnosed and are less known and still unusual. Histologically they are composed of smooth muscle cells with multiple fat cells and fibrous tissue. Their pathogenesis is still a stigmata and their preoperative diagnosis is still questionable. CASE REPORT HISTORY: A 39-year old woman presented at the University clinic for obstetrics and gynecology with complaints of a mild low abdominal and pelvic pain, increased frequency of vaginal bleeding and abdominal distension...
December 2016: Medical Archives
https://www.readbyqxmd.com/read/28209488/postoperative-maintenance-levonorgestrel-releasing-intrauterine-system-and-endometrioma-recurrence-a-randomized-controlled-study
#6
Yi-Jen Chen, Teh-Fu Hsu, Ben-Shian Huang, Hsiao-Wen Tsai, Yen-Hou Chang, Peng-Hui Wang
BACKGROUND: According to three randomized trials, levonorgestrel-releasing intrauterine system significantly reduced recurrent endometriosis- related pelvic pain at postoperative year 1. Only a few studies have evaluated the long-term effectiveness of the devicefor preventing endometrioma recurrence, and the effects of a levonorgestrel-releasing intrauterine system as a maintenance therapy remain unclear. OBJECTIVES: To evaluate whether a maintenance levonorgestrel-releasing intrauterine system is effective for preventing postoperative endometrioma recurrence...
February 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28205459/effects-of-an-antagonistic-analog-of-growth-hormone-releasing-hormone-on-endometriosis-in-a-mouse-model-and-in-vitro
#7
Frank Köster, Li Jin, Yuanming Shen, Andrew V Schally, Ren-Zhi Cai, Norman L Block, Daniela Hornung, Gabriele Marschner, Achim Rody, Jörg B Engel, Dominique Finas
Endometriosis is a benign gynecologic disorder causing dysmenorrhea, pelvic pain, and subfertility. Receptors for the growth hormone-releasing hormone (GHRH) were found in endometriotic tissues. Antagonists of GHRH have been used to inhibit the growth of endometriotic endometrial stromal cells. In this study, the GHRH receptor splice variant (SV) 1 was detected in human endometrial tissue samples by Western blots and quantitative reverse transcription polymerase chain reaction (qRT-PCR). The highest messenger RNA (mRNA) and protein levels of SV1 were found in eutopic endometrium from patients with endometriosis compared to ectopic endometriotic tissues and endometrium from normal patients...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28202356/bladder-capacity-is-a-biomarker-for-a-bladder-centric-versus-systemic-manifestation-in-interstitial-cystitis-bladder-pain-syndrome
#8
Stephen J Walker, Joao Zambon, Karl-Erik Andersson, Carl Langefeld, Catherine A Matthews, Gopal Badlani, Heather Bowman, Robert J Evans
PURPOSE: Interstitial cystitis/bladder pain syndrome (IC/BPS) presents a significant clinical challenge due to symptom heterogeneity and the myriad associated comorbid medical conditions. We recently reported that diminished bladder capacity (BC) may represent a specific IC/BPS sub-phenotype. The objective of this study is to investigate the relationship between anesthetic bladder capacity and clinical findings (urologic and non-urologic) in a cohort of IC/BPS patients who had undergone therapeutic urinary bladder hydrodistention...
February 12, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28192733/prospective-long-term-results-complications-and-risk-factors-in-pelvic-organ-prolapse-treatment-with-vaginal-mesh
#9
Inés M Laso-García, Miguel A Rodríguez-Cabello, Miguel A Jiménez-Cidre, Andrea Orosa-Andrada, David Carracedo-Calvo, Luis López-Fando, Francisco J Burgos-Revilla
OBJECTIVE: To assess the long-term results and complications of pelvic organ prolapse treatment with transvaginal mesh. STUDY DESIGN: Prospective observational study of 75 women who underwent surgery between 2005 and 2008 by the same surgeon. 44 patients (58,7%) underwent concomitant treatment of stress urinary incontinence. Anatomical criterion for failure was prolapse grade >I in any compartment. Analysis of functional features consisted of an assessment of urinary, sexual, and defecation symptoms, and pelvic pain...
February 6, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28187404/potentized-estrogen-in-homeopathic-treatment-of-endometriosis-associated-pelvic-pain-a-24-week-randomized-double-blind-placebo-controlled-study
#10
Marcus Zulian Teixeira, Sérgio Podgaec, Edmund Chada Baracat
OBJECTIVE: To evaluate the efficacy and safety of potentized estrogen compared to placebo in homeopathic treatment of endometriosis-associated pelvic pain (EAPP). STUDY DESIGN: The present was a 24-week, randomized, double-blind, placebo-controlled trial that included 50 women aged 18-45 years old with diagnosis of deeply infiltrating endometriosis based on magnetic resonance imaging or transvaginal ultrasound after bowel preparation, and score≥5 on a visual analogue scale (VAS: range 0 to 10) for endometriosis-associated pelvic pain...
January 25, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28185689/imaging-of-acute-pelvic-pain-in-girls-ovarian-torsion-and-beyond-%C3%A2
#11
REVIEW
Lena Naffaa, Tejaswini Deshmukh, Shanthan Tumu, Chris Johnson, Kevin P Boyd, Arthur B Meyers
: Identifying the etiology of acute pelvic pain in girls is often clinically challenging. Particularly in young girls, it is often difficult to determine if acute pelvic symptoms are originating from a gynecologic source or from a genitourinary or gastrointestinal etiology based on the child's clinical examination alone. Therefore, imaging plays a key role in establishing a diagnosis and in directing medical and surgical treatment. Pediatric gynecologic conditions, which can present acutely with pain or mass or both include ovarian torsion, hematometrocolpos, pelvic inflammatory disease, inguinal hernias containing an ovary or the uterus or both, adnexal cysts, pregnancy, vaginal foreign bodies, and ovarian vein thrombosis...
December 21, 2016: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28185319/gabapentenoids-in-pain-management-in-urological-chronic-pelvic-pain-syndrome-gabapentin-or-pregabalin
#12
Mayank Mohan Agarwal, Mudelin Elsi Sy
AIMS: To compare efficacy of gabapentin and pregabalin in patients with urological chronic pelvic-pain syndrome (UCPPS). METHODS: Design-retrospective, setting-urology outpatient services of a secondary-care private hospital, inclusion criteria-men 18-50 years, presenting with pelvic pain (lower abdomen, groin, scrotum, perineum, low-back, hip) with or without lower urinary tract symptoms for at least 3 months duration. Hospital database was searched using keywords for neuropathic pain (ICD9-729...
February 10, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28180092/robot-assisted-laparoscopic-resection-of-a-pelvic-schwannoma
#13
Sameer Chopra, Arjuna Dharmaraja, Raj Satkunasivam, Inderbir S Gill
There is minimal data within the literature demonstrating the use of robotics to resect pelvic, benign schwannoma(s). Herein, we describe a case of a 46-year-old transgender male that presented with complaints of left-sided pelvic pain. Pre-operatively, the etiology was unknown. The patient underwent robotic-assisted laparoscopic excision of the pelvic mass, including a 5-6 cm resection of the obturator nerve, successfully. Final pathology found a benign schwannoma. Schwannomas are difficult to diagnose pre- and intra-operatively and are thus frequently misdiagnosed as urologic or gynecologic lesions...
February 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28179199/robotic-cystotomy-for-pessary-extraction-with-vesicovaginal-fistula-repair
#14
Whitney Goldsberry, Daniel S Metzinger
STUDY OBJECTIVE: To demonstrate a robotic approach to foreign body extraction and vesicovaginal fistula repair. DESIGN: Video case presentation with narration discussing the step-by-step robotic surgical approach to the removal of a pessary, via cystotomy, followed by vesicovaginal fistula and cystotomy repair. SETTING: University of Louisville Hospital. The local Institutional Review Board deemed the video exempt from formal approval. PATIENT: A 77-year-old woman presented with complaints of vaginal leakage of urine, dysuria, and pelvic pain...
February 4, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28178074/a-common-pro-nociceptive-pain-modulation-profile-typifying-subgroups-of-chronic-pelvic-pain-syndromes-is-interrelated-with-enhanced-clinical-pain
#15
Grinberg Keren, Granot Michal, Lowenstein Lior, Abramov Liora, Weissman-Fogel Irit
Provoked vestibulodynia (PVD) and painful bladder syndrome (PBS), subgroups of chronic pelvic pain syndromes (CPPS), are considered to share common bio-physiological peripheral mechanisms. In addition, indications of a pro-nociceptive pain profile co-existing with psychological vulnerability suggests common dysfunctional pain processing and pain modulation in these two subgroups of CPPS. We therefore aimed at comparing the pain profile and psychological traits of PVD and PBS patients to see whether the pain profile contributes to inter-subject variability of clinical pain symptoms...
February 7, 2017: Pain
https://www.readbyqxmd.com/read/28177208/minimally-invasive-hysterectomy-for-benign-indications-an-update
#16
C Emi Bretschneider, Karl Jallad, Marie F Paraiso
Hysterectomy is one of the most commonly performed surgeries worldwide. Indication for hysterectomy is most often benign, which includes conditions such as prolapse, abnormal uterine bleeding, fibroids and pelvic pain. A broad range of surgical approaches exists for hysterectomy, ranging from open to minimally invasive techniques. Under this minimally invasive umbrella, the following techniques are included: vaginal hysterectomy (VH), laparoscopic hysterectomy (LH), and variations of those two techniques, such as laparoscopicassisted vaginal hysterectomy (LAVH), robotic-assisted hysterectomy (RH), laparo-endoscopic single-site laparoscopic hysterectomy (LESS), mini-laparoscopic hysterectomy (MLH), and natural orifice transluminal endoscopic surgery (NOTES) hysterectomy...
February 8, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28168715/efficacy-safety-and-tolerability-of-the-ccr1-antagonist-bay-86-5047-for-the-treatment-of-endometriosis-associated-pelvic-pain-a-randomized-controlled-trial
#17
Dietmar Trummer, Anja Walzer, Esther Groettrup-Wolfers, Heinz Schmitz
INTRODUCTION: Antagonism of CC chemokine receptor type 1 (CCR1) may provide a novel treatment approach for women with symptomatic endometriosis. Studies of CCR1 antagonists in these patients have not been reported. MATERIALS AND METHODS: Women (n = 110; 18-45 years) with symptomatic endometriosis were randomized to BAY 86-5047 or placebo for 12 weeks. Pelvic pain was assessed using the visual analogue scale (VAS) and women recorded the intake of pain medication in a diary...
February 6, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28164167/neonatal-maternal-separation-increases-susceptibility-to-experimental-colitis-and-acute-stress-exposure-in-male-mice
#18
Isabella M Fuentes, Natalie K Walker, Angela N Pierce, Briana R Holt, Elizabeth R Di Silvestro, Julie A Christianson
Experiencing early life stress can result in maladjusted stress response via dysregulation of the hypothalamic-pituitary-adrenal axis and serves as a risk factor for developing chronic pelvic pain disorders. We investigated whether neonatal maternal separation (NMS) would increase susceptibility to experimental colitis or exposure to acute or chronic stress. Male mice underwent NMS from postnatal day 1-21 and as adults were assessed for open field behavior, hindpaw sensitivity, and visceromotor response (VMR) to colorectal distension (CRD)...
December 2016: IBRO Rep
https://www.readbyqxmd.com/read/28162779/progestin-only-pills-may-be-a-better-first-line-treatment-for-endometriosis-than-combined-estrogen-progestin-contraceptive-pills
#19
REVIEW
Robert F Casper
For decades, combined estrogen-progestin oral contraceptive pills (OCPs) have been the first-line treatment for menstrual and pelvic pain associated with endometriosis without any clinical evidence of efficacy. Initial relief provided by OCPs is likely a result of improvement in primary dysmenorrhea. Biologic data and limited clinical evidence support a potential adverse effect of long-term use of OCPs on the progression of endometriosis. In contrast, there is randomized, controlled trial data to support the use of oral progestin-only treatment for pelvic pain associated with endometriosis and for suppressing the anatomic extent of endometriotic lesions...
February 2, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28162339/-534-chronic-pelvic-pain-is-effectively-treated-in-an-interdisciplinary-chronic-pain-rehabilitation-program
#20
A Aboussouan, K Martincin, K Huffman
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
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