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breast genitourinary colorectal lung ovarian

Li-Sheng Wu, Jia-Yi Qian, Minghai Wang, Haiwei Yang
The Wilms tumor suppressor, WT1 was first identified due to its essential role in the normal development of the human genitourinary system. Wilms tumor 1 associated protein (WTAP) was subsequently revealed to interact with WT1 using yeast two-hybrid screening. The present study identified 44 complete WTAP genes in the genomes of vertebrates, including fish, amphibians, birds and mammals. The vertebrate WTAP proteins clustered into the primate, rodent and teleost lineages using phylogenetic tree analysis. From 1,347 available SNPs in the human WTAP gene, 19 were identified to cause missense mutations...
September 2016: Molecular Medicine Reports
Zhixiang Xu, Jun Liu, Lipeng Gu, Xiaodong Ma, Bin Huang, Xuejun Pan
Oncologists have traditionally considered that tumorigenesis are closely related to classical nuclear estrogen receptors (ERs), such as estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ), through the ligands binding and target gene transcription induction. Estrogen-related receptors (ERRs) have similar structures with ERs, which are also gradually thought to be relevant to reproductive endocrine tumor diseases, even non-reproductive endocrine tumors. In this review, different subtypes of ERRs and their structures firstly will be introduced, then the expression patterns in gynecological oncology (i...
April 2016: Journal of Steroid Biochemistry and Molecular Biology
Daniel Le Bui, James Byunghoon Yu
PURPOSE: Cancer care is becoming increasingly complicated, in particular with the integration of radiation and surgery. Institutions may need to increase coordination between multidisciplinary clinical teams to optimize patient care. This study examines historical trends in adjuvant and neoadjuvant radiation therapy (ANRT) before or after cancer-directed surgery to identify disease sites that may benefit from coordinated care. METHODS: The Surveillance, Epidemiology, and End Results database was queried to identify patients with bladder cancer; breast cancer; cervical cancer; colorectal cancer; kidney cancer; cancer of the lung, bronchus, and pleura; lymphoma; melanoma; cancer of the oral cavity and pharynx; ovarian cancer; pancreatic cancer; prostate cancer; thyroid cancer; and uterine cancer from 1973 to 2011...
May 2015: Cancer Journal
Timothy L Fitzgerald, Jason Brinkley, Shannon Banks, Nasreen Vohra, Zachary P Englert, Emmanuel E Zervos
PURPOSE: Defining the benefits of resection of isolated non-colorectal, non-neuroendocrine (NCRNNE) liver metastases is difficult. To better understand the survival benefit in this group of patients, we conducted a systematic review of the previous literature. METHODS: Medline, Web of Knowledge, and manual searches were performed using search terms, such as "liver resection" and "primary tumor." Inclusion criteria were year>1990, >five patients, and median survival reported or derived...
December 2014: Langenbeck's Archives of Surgery
R Di Francia, R S Siesto, D Valente, D Spart, M Berretta
AIM: Both Fluoropirimidine and Oxaliplatin (FluOx) are the most common anticancer drugs used to treat lung, colorectal, ovarian, breast, head/neck, and genitourinary cancers. However, the efficacy of FluOx-based therapy is often compromised because of the severe risk of toxicity. Stratification of patients for multidrug response is a promising strategy for cancer treatment and personalized therapy. METHODS: Here, we review the late findings on the most appropriate gene variants related to the toxicity in patients receiving FluOx chemotherapy...
September 2012: European Review for Medical and Pharmacological Sciences
Mona Gandhi, Karen Oishi, Beth Zubal, Mario E Lacouture
CONTEXT: Improved therapies in oncology have resulted in increased survival across numerous malignancies, shifting attention to other aspects of the cancer experience. In particular, the impact of treatment-related toxicities has gained considerable attention, due to their physical and psychosocial effects, and possible impact on clinical outcome. These untoward events have not been examined from the survivors' perspective. OBJECTIVE: To identify and describe treatment-related toxicities having a negative effect on quality of life from the perspective of cancer survivors...
November 2010: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Jennifer S Temel, Joseph A Greer, Sonal Admane, Jessica Solis, Barbara J Cashavelly, Stephen Doherty, Rebecca Heist, William F Pirl
BACKGROUND: Advanced care planning (ACP) is considered an essential component of medical care in the United States, especially in patients with incurable diseases. However, little is known about clinical practices in outpatient oncology settings related to discussing end-of-life care and documenting code status preferences in ambulatory medical records. OBJECTIVE: To assess the rate of documentation of code status in the electronic longitudinal medical records (LMR) of patients with metastatic cancer...
February 2010: Journal of General Internal Medicine
Sarah R McWhinney, Richard M Goldberg, Howard L McLeod
Cisplatin, carboplatin, and oxaliplatin anticancer drugs are commonly used to treat lung, colorectal, ovarian, breast, head and neck, and genitourinary cancers. However, the efficacy of platinum-based drugs is often compromised because of the substantial risk for severe toxicities, including neurotoxicity. Neurotoxicity can result in both acute and chronic debilitation. Moreover, colorectal cancer patients treated with oxaliplatin discontinue therapy more often because of peripheral neuropathy than tumor progression, potentially compromising patient benefit...
January 2009: Molecular Cancer Therapeutics
Michelle Shayne, Eva Culakova, Marek S Poniewierski, Debra Wolff, David C Dale, Jeffrey Crawford, Gary H Lyman
BACKGROUND: This prospective study was undertaken to evaluate patient and treatment characteristics that contribute to hematologic toxicity in older cancer patients. METHODS: A nationwide study of 115 community oncology practices was conducted between 2002 and 2005 with data collected on 976 patients who had received chemotherapy for common malignancies, including lung cancer, colorectal cancer, breast cancer, ovarian cancer, genitourinary cancer, and lymphoma. Primary outcomes included severe neutropenia (SN) and febrile neutropenia (FN)...
October 1, 2007: Cancer
Margrit M Juretzka, Cimberly L Crawford, Christine Lee, Andrew Wilton, Samer Schuman, Dennis S Chi, Yukio Sonoda, Richard R Barakat, Nadeem R Abu-Rustum
OBJECTIVES: To describe the results of laparoscopic management of adnexal masses in women with a history of nongynecologic malignancy. METHODS: We conducted a retrospective review of 262 patients with history of prior nongynecologic malignancy who underwent laparoscopy for management of an adnexal mass between 1/1992 and 6/2004. RESULTS: Median patient age at laparoscopy was 55 years (range, 20-91 years), and median BMI was 25 kg/m2 (range, 14-41 kg/m2)...
May 2006: Gynecologic Oncology
Robert W Werling, Hadi Yaziji, Carlos E Bacchi, Allen M Gown
CDX2 is a recently cloned homeobox gene that encodes an intestine-specific transcription factor, expressed in the nuclei of epithelial cells throughout the intestine, from duodenum to rectum. While expression of CDX2 protein in primary and metastatic colorectal carcinomas has been previously documented, neither the sensitivity nor the specificity of CDX2 expression, as determined by immunohistochemistry, for colorectal adenocarcinoma has been determined. We performed an immunohistochemical survey of 476 tumors with a monoclonal antibody, CDX2-88, including 89 tumors from the colon and duodenum and 95 tumors from other gastrointestinal sites, including the esophagus, stomach, pancreatobiliary system, gastrointestinal carcinoids, and liver...
March 2003: American Journal of Surgical Pathology
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