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Wnt inflammation

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https://www.readbyqxmd.com/read/29770852/notch-inhibition-counteracts-paneth-cell-death-in-absence-of-caspase-8
#1
M K Jeon, E Kaemmerer, U Schneider, M Schiffer, C Klaus, J Hennings, T Clahsen, T Ackerstaff, M Niggemann, A Schippers, T Longerich, G Sellge, C Trautwein, N Wagner, C Liedtke, N Gassler
Opposing activities of Notch and Wnt signaling regulate mucosal barrier homeostasis and differentiation of intestinal epithelial cells. Specifically, Wnt activity is essential for differentiation of secretory cells including Wnt3-producing Paneth cells, whereas Notch signaling strongly promotes generation of absorptive cells. Loss of caspase-8 in intestinal epithelium (casp8∆int ) is associated with fulminant epithelial necroptosis, severe Paneth cell death, secondary intestinal inflammation, and an increase in Notch activity...
May 16, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29753753/dietary-polyphenols-and-neurogenesis-molecular-interactions-and-implication-for-brain-ageing-and-cognition
#2
REVIEW
F Sarubbo, D Moranta, G Pani
The increased number of elderly people worldwide poses a major medical and socio-economic challenge: the search of strategies to combat the consequences of the aging process. Oxidative stress and inflammation have been pointed out as the leading causes of brain aging, which in turn alters the functionality of brain. In this context, decline in adult neurogenesis (AN), due to modifications in the neural progenitor stem cells (NSCs) and their microenvironment, is among the aging alterations contributing to cognitive decline...
May 10, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29743880/-trypanosoma-cruzi-exploits-wnt-signaling-pathway-to-promote-its-intracellular-replication-in-macrophages
#3
Ximena Volpini, Laura F Ambrosio, Laura Fozzatti, Constanza Insfran, Cinthia C Stempin, Laura Cervi, Claudia Cristina Motran
During the acute phase of Trypanosoma cruzi infection, macrophages can act as host cells for the parasites as well as effector cells in the early anti-parasitic immune response. Thus, the targeting of specific signaling pathways could modulate macrophages response to restrict parasite replication and instruct an appropriate adaptive response. Recently, it has become evident that Wnt signaling has immunomodulatory functions during inflammation and infection. Here, we tested the hypothesis that during T. cruzi infection, the activation of Wnt signaling pathway in macrophages plays a role in modulating the inflammatory/tolerogenic response and therefore regulating the control of parasite replication...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29740203/olfactomedin-4-in-digestive-diseases-a-mini-review
#4
REVIEW
Xin-Yu Wang, Sheng-Hui Chen, Ya-Nan Zhang, Cheng-Fu Xu
Olfactomedin-4 (OLFM4, GW112, hGC-1) is a glycoprotein belonging to the olfactomedin family. The expression of OLFM4 is strong in the small intestine, colon and prostate, and moderate in the stomach and bone marrow. Previous studies have revealed that OLFM4 is closely associated with many digestive diseases. Up-regulation of OLFM4 has been detected in the Helicobacter pylori ( H. pylori )-infected gastric mucosa, inflammatory bowel disease tissue and gastrointestinal malignancies, including gastric cancer, colorectal cancer, pancreatic cancer and gallbladder cancer...
May 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29738483/proline-rich-protein-tyrosine-kinase-2-in-inflammation-and-cancer
#5
REVIEW
Xiangdong Zhu, Yonghua Bao, Yongchen Guo, Wancai Yang
Focal adhesion kinase (FAK) and its homologous FAK-related proline-rich tyrosine kinase 2 (Pyk2) contain the same domain, exhibit high sequence homology and are defined as a distinct family of non-receptor tyrosine kinases. This group of kinases plays critical roles in cytoskeletal dynamics and cell adhesion by regulating survival and growth signaling. This review summarizes the physiological and pathological functions of Pyk2 in inflammation and cancers. In particular, overexpression of Pyk2 in cancerous tissues is correlated with poor outcomes...
May 8, 2018: Cancers
https://www.readbyqxmd.com/read/29737515/phytosomal-curcumin-inhibits-tumor-growth-in-colitis-associated-colorectal-cancer
#6
Reyhaneh Moradi Marjaneh, Farzad Rahmani, Seyed Mahdi Hassanian, Nastaran Rezaei, Milad Hashemzehi, Afsane Bahrami, Fatemeh Ariakia, Hamid Fiuji, Amirhosein Sahebkar, Amir Avan, Majid Khazaei
Colorectal-cancer (CRC) is the third leading cause of death due to cancer, supporting the need for identification of novel anticancer drug to improve the efficacy of current-therapy. There is growing bodies of data showing the antitumor-activity of curcumin, although it is associated with low absorption. The aim of current study was explored the therapeutic-potential of novel phytosomal curcumin as well as its application in combination with 5-Flurouracil (5-FU) in a mouse-model of colitis-associated colon-cancer...
May 8, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29722559/mir-142-3p-is-associated-with-aberrant-wingless-integrase-i-wnt-signaling-during-airway-remodeling-in-asthma
#7
Sabine Bartel, Gianni Carraro, Francesca Alessandrini, Susanne Krauss-Etschmann, Fabio L M Ricciardolo, Saverio Bellusci
BACKGROUND: Asthma is characterized by a chronic inflammation and remodeling of the airways. While inflammation can be controlled, therapeutic options to revert remodeling do not exist. Thus, there is a large and unmet need to understand the underlying molecular mechanisms in order to develop novel therapies. OBJECTIVE: we previously identified a pivotal role for miR-142-3p in regulating airway smooth muscle precursor (ASM) cell proliferation during lung development by fine-tuning the Wingless/Integrase I (WNT) signaling...
May 3, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29717038/lipidomic-profiling-reveals-soluble-epoxide-hydrolase-as-a-therapeutic-target-of-obesity-induced-colonic-inflammation
#8
Weicang Wang, Jun Yang, Jianan Zhang, Yuxin Wang, Sung Hee Hwang, Weipeng Qi, Debin Wan, Daeyoung Kim, Jia Sun, Katherine Z Sanidad, Haixia Yang, Yeonhwa Park, Jun-Yan Liu, Xinfeng Zhao, Xiaohui Zheng, Zhenhua Liu, Bruce D Hammock, Guodong Zhang
Obesity is associated with enhanced colonic inflammation, which is a major risk factor for colorectal cancer. Considering the obesity epidemic in Western countries, it is important to identify novel therapeutic targets for obesity-induced colonic inflammation, to develop targeted strategies for prevention. Eicosanoids are endogenous lipid signaling molecules involved in regulating inflammation and immune responses. Using an LC-MS/MS-based lipidomics approach, we find that obesity-induced colonic inflammation is associated with increased expression of soluble epoxide hydrolase (sEH) and its eicosanoid metabolites, termed fatty acid diols, in colon tissue...
May 1, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29706964/crosstalk-between-peroxisome-proliferator-activated-receptor-gamma-and-the-canonical-wnt-%C3%AE-catenin-pathway-in-chronic-inflammation-and-oxidative-stress-during-carcinogenesis
#9
REVIEW
Alexandre Vallée, Yves Lecarpentier
Inflammation and oxidative stress are common and co-substantial pathological processes accompanying, promoting, and even initiating numerous cancers. The canonical WNT/β-catenin pathway and peroxisome proliferator-activated receptor gamma (PPARγ) generally work in opposition. If one of them is upregulated, the other one is downregulated and vice versa . WNT/β-catenin signaling is upregulated in inflammatory processes and oxidative stress and in many cancers, although there are some exceptions for cancers...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29706467/hpv-molecular-pathways-and-targets
#10
REVIEW
Shilpi Gupta, Prabhat Kumar, Bhudev C Das
Infection of high-risk human papillomaviruses (HPVs) is a prerequisite for the development of cervical carcinoma. HPV infections are also implicated in the development of other types of carcinomas. Chronic or persistent infection of HPV is essential but HPV alone is inadequate, additional endogenous or exogenous cues are needed along with HPV to induce cervical carcinogenesis. The strategies that high-risk HPVs have developed in differentiating epithelial cells to reach a DNA-synthesis competent state leading to tumorigenic transformation are basically due to overexpression of the E6 and E7 oncoproteins and the activation of diverse cellular regulatory or signaling pathways that are targeted by them...
April 5, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29694513/mir-27a-protects-human-mitral-valve-interstitial-cell-from-tnf-%C3%AE-induced-inflammatory-injury-via-up-regulation-of-nell-1
#11
Honglei Chen, Zhixu Zhang, Li Zhang, Junzhi Wang, Minghui Zhang, Bin Zhu
MicroRNAs (miRNAs) have been reported to be associated with heart valve disease, which can be caused by inflammation. This study aimed to investigate the functional impacts of miR-27a on TNF-α-induced inflammatory injury in human mitral valve interstitial cells (hMVICs). hMVICs were subjected to 40 ng/mL TNF-α for 48 h, before which the expressions of miR-27a and NELL-1 in hMVICs were altered by stable transfection. Trypan blue staining, BrdU incorporation assay, flow cytometry detection, ELISA, and western blot assay were performed to detect cell proliferation, apoptosis, and the release of proinflammatory cytokines...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29662489/immunological-approaches-towards-cancer-and-inflammation-a-cross-talk
#12
REVIEW
Xinglong Qu, Ying Tang, Shucheng Hua
The inflammation is the protective response of the body against various harmful stimuli; however, the aberrant and inappropriate activation tends to become harmful. The acute inflammatory response tends to resolved once the offending agent is subside but this acute response becomes chronic in nature when the body is unable to successfully neutralized the noxious stimuli. This chronic inflammatory microenvironment is associated with the release of various pro-inflammatory and oncogenic mediators such as nitric oxide (NO), cytokines [IL-1β, IL-2, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)], growth factor, and chemokines...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29659554/demyelination-in-multiple-sclerosis-reprogramming-energy-metabolism-and-potential-ppar%C3%AE-agonist-treatment-approaches
#13
REVIEW
Alexandre Vallée, Yves Lecarpentier, Rémy Guillevin, Jean-Noël Vallée
Demyelination in multiple sclerosis (MS) cells is the site of several energy metabolic abnormalities driven by dysregulation between the opposed interplay of peroxisome proliferator-activated receptor γ (PPARγ) and WNT/β-catenin pathways. We focus our review on the opposing interactions observed in demyelinating processes in MS between the canonical WNT/β-catenin pathway and PPARγ and their reprogramming energy metabolism implications. Demyelination in MS is associated with chronic inflammation, which is itself associated with the release of cytokines by CD4⁺ Th17 cells, and downregulation of PPARγ expression leading to the upregulation of the WNT/β-catenin pathway...
April 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29656209/phosphorylation-of-low-density-lipoprotein-receptor-related-protein-6-is-involved-in-receptor-for-advanced-glycation-end-product-mediated-%C3%AE-catenin-stabilization-in-a-toluene-diisocyanate-induced-asthma-model
#14
Jing Xiong, Wenqu Zhao, Yun Lin, Lihong Yao, Guohua Huang, Changhui Yu, Hangming Dong, Guanhua Xiao, Haijin Zhao, Shaoxi Cai
BACKGROUND: We have previously demonstrated that the receptor for advanced glycation end products (RAGE)/β-catenin axis plays a vital role in regulating airway inflammation and airway remodeling in a toluene diisocyanate (TDI)-induced murine asthma model. However, the exact mechanism of β-catenin activation remains unclear. Given that phosphorylation of the low-density lipoprotein receptor-related protein 6 (Lrp6) is a key step in mediating β-catenin stabilization in canonical wnt/β-catenin signaling, we explored the possible relationship between RAGE and Lrp6 in regulating β-catenin stabilization in TDI-induced asthma...
April 12, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29650970/crosstalk-between-gut-microbiota-and-sirtuin-3-in-colonic-inflammation-and-tumorigenesis
#15
Yong Zhang, Xiao-Lan Wang, Min Zhou, Chao Kang, He-Dong Lang, Meng-Ting Chen, Suo-Cheng Hui, Bin Wang, Man-Tian Mi
Colorectal cancer (CRC) is a disease involving a variety of genetic and environmental factors. Sirtuin-3 (Sirt3) is expressed at a low level in cancer tissues of CRC, but it is unclear how Sirt3 modulates colonic tumorigenesis. In this study, we found that gut microbiota play a central role in the resistance to CRC tumor formation in wild-type (WT) mice through APC (Adenomatous Polyposis Coli)-mutant mouse microbiota transfer via Wnt signaling. We also found that Sirt3-deficient mice were hypersusceptible to colonic inflammation and tumor development through altered intestinal integrity and p38 signaling, respectively...
April 13, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29626750/novel-regulatory-roles-of-wnt1-in-infection-associated-colorectal-cancer
#16
Jianwei Wang, Rong Lu, Xinghui Fu, Zhou Dan, Yong-Guo Zhang, Xinxia Chang, Qisha Liu, Yinglin Xia, Xingyin Liu, Jun Sun
Salmonella infection is a major public health concern, and colonization in humans can be chronic and increases the risk of cancers. Wnt signaling is a key pathway for intestinal renewal and development, inflammation, and tumorigenesis. In the current study, we report a novel role of Wnt1 in infection and colon cancer using cell culture models, a Salmonella-colitis colon cancer model, and human samples. In contrast to the bacteria-induced increases in Wnt2 and Wnt11, Salmonella colonization significantly reduced the level of Wnt1 in intestinal epithelial cells in vivo and in vitro...
April 4, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29605095/activated-renal-tubular-wnt-%C3%AE-catenin-signaling-triggers-renal-inflammation-during-overload-proteinuria
#17
Dickson W L Wong, Wai Han Yiu, Kam Wa Chan, Ye Li, Bin Li, Sarah W Y Lok, Makoto M Taketo, Peter Igarashi, Loretta Y Y Chan, Joseph C K Leung, Kar Neng Lai, Sydney C W Tang
Imbalance of Wnt/β-catenin signaling in renal cells is associated with renal dysfunction, yet the precise mechanism is poorly understood. Previously we observed activated Wnt/β-catenin signaling in renal tubules during proteinuric nephropathy with an unknown net effect. Therefore, to identify the definitive role of tubular Wnt/β-catenin, we generated a novel transgenic "Tubcat" mouse conditionally expressing stabilized β-catenin specifically in renal tubules following tamoxifen administration...
March 28, 2018: Kidney International
https://www.readbyqxmd.com/read/29602775/canonical-wnt-signaling-in-cd11c-apcs-regulates-microbiota-induced-inflammation-and-immune-cell-homeostasis-in-the-colon
#18
Daniel Swafford, Arulkumaran Shanmugam, Punithavathi Ranganathan, Mohamed S Hussein, Pandelakis A Koni, Puttur D Prasad, Muthusamy Thangaraju, Santhakumar Manicassamy
Aberrant Wnt/β-catenin signaling occurs in several inflammatory diseases, including inflammatory bowel disease and inflammatory bowel disease-associated colon carcinogenesis. However, its role in shaping mucosal immune responses to commensals in the gut remains unknown. In this study, we investigated the importance of canonical Wnt signaling in CD11c+ APCs in controlling intestinal inflammation. Using a mouse model of ulcerative colitis, we demonstrated that canonical Wnt signaling in intestinal CD11c+ APCs controls intestinal inflammation by imparting an anti-inflammatory phenotype...
March 30, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29595457/-neurotrophin-3-enhances-the-osteogenesis-ability-of-human-bone-marrow-mesenchymal-stem-cells-stimulated-by-lipopolysaccharide
#19
Shanqiang Zhang, Haifeng Jin, Lijie Yao, Fengchun Deng, Lei Shen
Objective To investigate the protective effect of neurotrophin-3 (NT-3) on human bone marrow mesenchymal stem cells (hBMSCs) and its ability to promote the differentiation of hBMSCs into osteoblasts in the inflammatory environment. Methods The cell inflammation model was established by lipopolysaccharide (LPS). The hBMSCs without any stimulation was defined as the inflammatory control group; the hBMSCs stimulated by 100 ng/mL human NT-3 recombinant protein as the NT-3 group; the hBMSCs stimulated by 100 mmol/L pyrvinium pamoate (PP) for 12 hours and then stimulated by 100 ng/mL human NT-3 recombinant protein as the Wnt inhibitor group; the normal cultured hBMSCs as the normal control group...
January 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29584756/transcriptional-signature-associated-with-early-rheumatoid-arthritis-and-healthy-individuals-at-high-risk-to-develop-the-disease
#20
N Macías-Segura, J E Castañeda-Delgado, Y Bastian, D Santiago-Algarra, J D Castillo-Ortiz, A L Alemán-Navarro, E Jaime-Sánchez, M Gomez-Moreno, C A Saucedo-Toral, Edgar E Lara-Ramírez, M Zapata-Zuñiga, L Enciso-Moreno, R González-Amaro, C Ramos-Remus, J A Enciso-Moreno
BACKGROUND: Little is known regarding the mechanisms underlying the loss of tolerance in the early and preclinical stages of autoimmune diseases. The aim of this work was to identify the transcriptional profile and signaling pathways associated to non-treated early rheumatoid arthritis (RA) and subjects at high risk. Several biomarker candidates for early RA are proposed. METHODS: Whole blood total RNA was obtained from non-treated early RA patients with <1 year of evolution as well as from healthy first-degree relatives of patients with RA (FDR) classified as ACCP+ and ACCP- according to their antibodies serum levels against cyclic citrullinated peptides...
2018: PloS One
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