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https://www.readbyqxmd.com/read/28933635/factors-involved-in-human-papillomavirus-hpv-vaccine-hesitancy-among-women-in-the-south-east-asian-region-sear-and-western-pacific-region-wpr-a-scoping-review
#1
Diviya Santhanes, Che Pui Wong, Yan Ye Yap, Saw Pui San, Nathorn Chaiyakunapruk, Tahir Mehmood Khan
A scoping review was performed to identify factors that may lead to human papillomavirus (HPV) vaccine hesitancy among women in low- and middle-income countries in South East Asian Region (SEAR) and Western Pacific Region (WPR). A systematic search of English and non-English articles using Pubmed, EMBASE, PsycINFO, Cochrane, MEDLINE, and CINAHL plus was conducted. Only 63 studies conducted in SEAR and WPR were included from inception until December 2016. Results of these studies have shown that poor awareness and knowledge of practices on cervical cancer prevention was evident in both SEAR and WPR...
September 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28929038/drainage-after-modified-radical-mastectomy-a-methodological-mini-review
#2
REVIEW
George S Stoyanov, Dragostina Tsocheva, Katerina Marinova, Emil Dobrev, Rumen Nenkov
Breast cancer is a socially relevant group of malignant conditions of the mammary gland, affecting both males and females. Most commonly the surgical approach of choice is a modified radical mastectomy (MRM), due to it allowing for both the removal of the main tumor mass and adjacent glandular tissue, which are suspected of infiltration and multifocality of the process, and a sentinel axillary lymph node removal. Most common post-surgical complications following MRM are the formation of a hematoma, the infection of the surgical wound and the formation of a seroma...
July 10, 2017: Curēus
https://www.readbyqxmd.com/read/28919695/%C3%AE-defensins-an-innate-defense-for-bovine-mastitis
#3
REVIEW
Ankita Gurao, Sudhir Kumar Kashyap, Ravinder Singh
Immune challenges are inevitable for livestock that are exposed to a varied range of adverse conditions ranging from environmental to pathogenic stresses. The β-defensins are antimicrobial peptides, belonging to "defensin" family and therefore acts as the first line of defense against the major infections occurring in dairy cattle including intramammary infections. The better resistance to mastitis displayed by Bos indicus is implicit in the fact that they have better adapted and also has more sequence variation with rare allele conserved due to lesser artificial selection pressure than that of Bos taurus...
August 2017: Veterinary World
https://www.readbyqxmd.com/read/28919236/biomarkers-for-diagnosis-of-pediatric-acute-neuropsychiatric-syndrome-pans-sensitivity-and-specificity-of-the-cunningham-panel
#4
Eva Hesselmark, Susanne Bejerot
OBJECTIVE: Pediatric Acute Neuropsychiatric Syndrome (PANS) and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are conditions marked by sudden onset of obsessive-compulsive disorder (OCD), tics, or avoidant/restrictive food intake in combination with multiple psychiatric symptoms. A diagnosis of PANS or PANDAS may be supported by the Cunningham Panel, a commercially available set of immunologic assays currently in clinical use. However, the relationship between Cunningham Panel results and patient symptoms remains unclear...
September 9, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28890990/child-with-allergies-or-allergic-reactions
#5
REVIEW
Reshma A, Arun K Baranwal
Incidence of allergic disorders in children has increased significantly over time due to environmental and life-style changes. These include allergic rhinitis, atopic dermatitis, allergic conjunctivitis, food allergies, bronchial asthma, drug allergies, insect bites and anaphylaxis; most being IgE-mediated type 1 hypersensitivity reactions to common environmental and food antigens. Although most of them are self-limiting, they may adversely affect the quality of life and sometimes become life-threatening as well...
September 11, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28877682/epidemiologic-and-clinical-parameters-of-west-nile-virus-infections-in-humans-a-scoping-review
#6
Man Wah Yeung, Emily Shing, Mark Nelder, Beate Sander
BACKGROUND: Clinical syndromes associated with West Nile virus (WNV) infection range from fever to neuroinvasive disease. Understanding WNV epidemiology and disease history is important for guiding patient care and healthcare decision-making. The objective of this review was to characterize the existing body of peer-reviewed and surveillance literature on WNV syndromes and summarize epidemiologic and clinical parameters. METHODS: We followed scoping review methodology described by the Joanna Briggs Institute...
September 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28876298/mailed-human-papillomavirus-self-collection-with-papanicolaou-test-referral-for-infrequently-screened-women-in-the-united-states
#7
Jennifer S Smith, Andrea C Des Marais, Allison M Deal, Alice R Richman, Carolina Perez-Heydrich, Belinda Yen-Lieberman, Lynn Barclay, Jerome Belinson, Allen Rinas, Noel T Brewer
BACKGROUND: Testing for high-risk human papillomavirus (HPV) infection using mailed, self-collected samples is a promising approach to increase screening in women who do not attend clinic screening at recommended intervals. METHODS: To assess this intervention among high-risk women in the United States, 429 women without a Papanicolaou (Pap) test in 4 or more years (overdue by US guidelines) were recruited from the general population. Participants aged 30 to 65 years were mailed a kit to self-collect a cervicovaginal sample at home, return the sample by mail, and receive HPV results by telephone, with referral to follow-up cytological Pap testing at a local clinic...
July 26, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28875151/molecular-characterization-structural-modeling-and-evaluation-of-antimicrobial-activity-of-basrai-thaumatin-like-protein-against-fungal-infection
#8
Nusrat Yasmin, Mahjabeen Saleem, Mamoona Naz, Roquyya Gul, Hafiz Muzzammel Rehman
A thaumatin-like protein gene from Basrai banana was cloned and expressed in Escherichia coli. Amplified gene product was cloned into pTZ57R/T vector and subcloned into expression vector pET22b(+) and resulting pET22b-basrai TLP construct was introduced into E. coli BL21. Maximum protein expression was obtained at 0.7 mM IPTG concentration after 6 hours at 37°C. Western blot analysis showed the presence of approximately 20 kDa protein in induced cells. Basrai antifungal TLP was tried as pharmacological agent against fungal disease...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28870269/failure-to-communicate-transmission-of-extensively-drug-resistant-bla-oxa-237-containing-acinetobacter-baumannii-multiple-facilities-in-oregon-2012-2014
#9
Genevieve L Buser, P Maureen Cassidy, Margaret C Cunningham, Susan Rudin, Andrea M Hujer, Robert Vega, Jon P Furuno, Steven H Marshall, Paul G Higgins, Michael R Jacobs, Meredith S Wright, Mark D Adams, Robert A Bonomo, Christopher D Pfeiffer, Zintars G Beldavs
OBJECTIVE To determine the scope, source, and mode of transmission of a multifacility outbreak of extensively drug-resistant (XDR) Acinetobacter baumannii. DESIGN Outbreak investigation. SETTING AND PARTICIPANTS Residents and patients in skilled nursing facilities, long-term acute-care hospital, and acute-care hospitals. METHODS A case was defined as the incident isolate from clinical or surveillance cultures of XDR Acinetobacter baumannii resistant to imipenem or meropenem and nonsusceptible to all but 1 or 2 antibiotic classes in a patient in an Oregon healthcare facility during January 2012-December 2014...
September 5, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28864808/oral-health-care-in-the-future-expansion-of-the-scope-of-dental-practice-to-improve-health
#10
Ira B Lamster, Noreen Myers-Wright
The health care environment in the U.S. is changing. The population is aging, the prevalence of non-communicable diseases (NCDs) is increasing, edentulism is decreasing, and periodontal infection/inflammation has been identified as a risk factor for NCDs. These trends offer an opportunity for oral health care providers to broaden the scope of traditional dental practice, specifically becoming more involved in the management of the general health of patients. This new practice paradigm will promote a closer integration with the larger health care system...
September 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28862475/a-survey-of-canadian-interprofessional-student-run-free-clinics
#11
Enoch Ng, Tina Hu
Student-run free clinics (SRFCs) have existed in Canada since 1971, providing interprofessional healthcare to underserved populations. SRFCs are seen as vehicles for socially accountable health professional education. Literature on how Canadian SRFC function is lacking. Web-based surveys were sent to student leaders from Canadian SRFCs regarding their 2014 activities. All six fully-functioning SRFCs responded reporting on the following: services provided, professions involved, governing structure, funding sources, clients seen, types of care sought, students and preceptors involved, as well as perceived strengths, weaknesses, opportunities and threats...
September 1, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28862291/trans-activation-response-element-rna-is-detectable-in-the-plasma-of-a-subset-of-aviremic-hiv-1-infected-patients
#12
Anžej Hladnik, Jana Ferdin, Katja Goričar, G Steven Deeks, M Boris Peterlin, Ana Plemenitaš, Dolžan Vita, Lenassi Metka
Determining the HIV-1 reservoir size in infected individuals is of great importance for improvement of their treatment. Plasma trans-activation response element (TAR) RNA has been suggested as one of the possible biomarkers. TAR RNA is produced during non-processive transcription in HIV-1 productively infected and latent T cells. Here, plasma samples and paired exosome samples of 55 subjects from the observational SCOPE cohort were analysed for the presence of TAR RNA. First, a PCR-based assay was optimized, which provided 100% specificity and 100% sensitivity in differentiating HIV-1 infected non-controllers from uninfected individuals...
September 2017: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/28856488/tubercular-intestinal-strictures-show-a-poor-response-to-anti-tuberculous-therapy
#13
Piyush Aggarwal, Saurabh Kedia, Raju Sharma, Sawan Bopanna, Kumble Seetharama Madhusudhan, Dawesh P Yadav, Sandeep Goyal, Saransh Jain, Venigalla Pratap Mouli, Prasenjit Das, Siddhartha Dattagupta, Govind Makharia, Vineet Ahuja
BACKGROUND: The literature on resolution of intestinal strictures in patients with intestinal tuberculosis (ITB) after anti-tuberculous therapy (ATT) is sparse and ambivalent. We aimed to assess the frequency of stricture resolution after ATT and its predictors. METHODS: This ambispective cohort study included consecutive ITB patients with strictures who received ATT for ≥6 months and were on regular follow-up between January 2004 and December 2015. Resolution of stricture was assessed at the end of ATT by endoscopy/radiology...
August 30, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28852305/are-our-endoscopy-patients-at-risk-for-pyogenic-liver-abscess
#14
EDITORIAL
Herwig Cerwenka, Peter Schemmer
This is an editorial comment on a recent publication reporting an increased rate of pyogenic liver abscesses (PLAs) after upper gastrointestinal panendoscopy. Its aim is to critically highlight the findings, limitations and potential clinical implications of this study. Issues of the mucosal barrier, the microbial flora, administration of antibiotics and underlying diseases are discussed. The probability of PLAs after endoscopies is not exactly known and the length of the "incubation period" remains unclear, but a possible causality should already suffice to make us think how to avoid them...
August 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28829079/technetium-99m-based-small-molecule-radiopharmaceuticals-and-radiotracers-targeting-inflammation-and-infection
#15
Torsten Kniess, Markus Laube, Frank Wüst, Jens Pietzsch
In nuclear medicine, the detection of inflamed and infected lesions is of growing interest. Extensive efforts have been made to develop radiopharmaceuticals specific for inflammation or for discriminating sterile inflammation from infection. (99m)Tc is the worldwide most widely used radioisotope for SPECT imaging. The scope of this review article is to give an overview on the development of (99m)Tc-labelled small molecule radiotracers targeting inflammatory lesions and infections, ranging from their radiopharmacological evaluation to examples of their clinical applications...
August 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28819982/hiv-testing-in-the-dental-setting-perspectives-and-practices-of-experienced-dental-professionals
#16
Carrigan L Parish, Karolynn Siegel, Terri Liguori, Stephen N Abel, Harold A Pollack, Margaret R Pereyra, Lisa R Metsch
The dental setting is a largely untapped venue to identify patients with undiagnosed HIV infection. Yet, uptake of rapid HIV testing within the dental community remains low. This study sought to better understand the experiences of dental professionals who have administered the test and how these experiences might inform efforts to promote greater uptake of rapid HIV testing in dental settings. Qualitative interviews were conducted with United States dentists (N = 37) and hygienists (N = 5) who offered rapid HIV testing in their practices...
August 18, 2017: AIDS Care
https://www.readbyqxmd.com/read/28817599/anguillicola-crassus-infection-affects-mrna-expression-levels-in-gas-gland-tissue-of-european-yellow-and-silver-eel
#17
Gabriel Schneebauer, Ron P Dirks, Bernd Pelster
Using Illumina sequencing, we investigated transcriptional changes caused by the nematode Anguillicola crassus within yellow and silver eels by comparing swimbladder samples of uninfected yellow with infected yellow eels, and uninfected silver with infected silver eels, respectively. In yellow eel gas gland, the infection caused a modification of steady state mRNA levels of 1675 genes, most of them being upregulated. Functional annotation analysis based on GO terms was used to categorize identified genes with regard to swimbladder metabolism or response to the infection...
2017: PloS One
https://www.readbyqxmd.com/read/28814655/identifying-climate-drivers-of-infectious-disease-dynamics-recent-advances-and-challenges-ahead
#18
REVIEW
C Jessica E Metcalf, Katharine S Walter, Amy Wesolowski, Caroline O Buckee, Elena Shevliakova, Andrew J Tatem, William R Boos, Daniel M Weinberger, Virginia E Pitzer
Climate change is likely to profoundly modulate the burden of infectious diseases. However, attributing health impacts to a changing climate requires being able to associate changes in infectious disease incidence with the potentially complex influences of climate. This aim is further complicated by nonlinear feedbacks inherent in the dynamics of many infections, driven by the processes of immunity and transmission. Here, we detail the mechanisms by which climate drivers can shape infectious disease incidence, from direct effects on vector life history to indirect effects on human susceptibility, and detail the scope of variation available with which to probe these mechanisms...
August 16, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28809541/ubiquitin-chains-modified-by-the-bacterial-ligase-sdea-are-protected-from-deubiquitinase-hydrolysis
#19
Kedar Puvar, Yiyang Zhou, Jiazhang Qiu, Zhao-Qing Luo, Mary J Wirth, Chittaranjan Das
The SidE family of Legionella pneumophila effectors is a unique group of ubiquitin-modifying enzymes. Along with catalyzing NAD(+)-dependent ubiquitination of certain host proteins independent of the canonical E1/E2/E3 pathway, they have also been shown to produce phosphoribosylated free ubiquitin. This modified ubiquitin product is incompatible with conventional E1/E2/E3 ubiquitination processes, with the potential to lock down various cellular functions that are dependent on ubiquitin signaling. Here, we show that in addition to free ubiquitin, Lys63-, Lys48-, Lys11-, and Met1-linked diubiquitin chains are also modified by SdeA in a similar fashion...
September 12, 2017: Biochemistry
https://www.readbyqxmd.com/read/28807188/the-global-burden-of-tuberculosis-mortality-in-children-a-mathematical-modelling-study
#20
Peter J Dodd, Courtney M Yuen, Charalambos Sismanidis, James A Seddon, Helen E Jenkins
BACKGROUND: Tuberculosis in children is increasingly recognised as an important component of the global tuberculosis burden, with an estimated 1 million cases in 2015. Although younger children are vulnerable to severe forms of tuberculosis disease, no age-disaggregated estimates of paediatric tuberculosis mortality exist, and tuberculosis has never been included in official estimates of under-5 child mortality. We aimed to produce a global mortality burden estimate in children using a complementary approach not dependent on vital registration data...
September 2017: Lancet Global Health
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