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https://www.readbyqxmd.com/read/28539450/mimic-phosphorylation-of-a-%C3%AE-c1-encoded-by-tylccnb-impairs-its-functions-as-a-viral-suppressor-of-rna-silencing-and-a-symptom-determinant
#1
Xueting Zhong, Zhan Qi Wang, Ruyuan Xiao, Linge Cao, Yaqin Wang, Yan Xie, Xueping Zhou
Phosphorylation of the βC1 protein encoded by the betasatellite of tomato yellow leaf curl China virus (TYLCCNB-βC1) by SNF1-related protein kinase 1 (SnRK1) plays a critical role in defense of host plants against geminivirus infection in Nicotiana benthamiana However, how phosphorylation of TYLCCNB-βC1 impacts its pathogenic functions during viral infection remains elusive. In this study, we identified two additional tyrosine residues in TYLCCNB-βC1 that are phosphorylated by SnRK1. The effects of TYLCCNB-βC1 phosphorylation on its functions as a viral suppressor of RNA silencing (VSR) and a symptom determinant were investigated via phosphorylation- mimic mutants in N...
May 24, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28532815/attitudes-and-practices-of-irish-hospital-based-physicians-towards-hand-hygiene-and-handrubbing-using-alcohol-based-hand-rubs-a-comparison-between-2007-and-2015
#2
Liz M Kingston, Barbara L Slevin, Nuala H O'Connell, Colum P Dunne
BACKGROUND: Hand hygiene is the cornerstone of infection prevention and control practices and reduces healthcare-associated infections significantly. Yet, international evidence suggests that medical doctors demonstrate poor compliance. AIM: To explore and compare practices and attitudes towards hand hygiene, in particular handrubbing using alcohol-based hand rubs (ABHR), among hospital-based physicians in Ireland between 2007 and 2015. METHODS: In 2007, a random sample of doctors in a large teaching hospital was invited to complete a postal survey using a validated questionnaire...
May 19, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28531183/a-scoping-review-on-bio-aerosols-in-healthcare-and-the-dental-environment
#3
Charifa Zemouri, Hans de Soet, Wim Crielaard, Alexa Laheij
BACKGROUND: Bio-aerosols originate from different sources and their potentially pathogenic nature may form a hazard to healthcare workers and patients. So far no extensive review on existing evidence regarding bio-aerosols is available. OBJECTIVES: This study aimed to review evidence on bio-aerosols in healthcare and the dental setting. The objectives were 1) What are the sources that generate bio-aerosols?; 2) What is the microbial load and composition of bio-aerosols and how were they measured?; and 3) What is the hazard posed by pathogenic micro-organisms transported via the aerosol route of transmission? METHODS: Systematic scoping review design...
2017: PloS One
https://www.readbyqxmd.com/read/28508384/endoscopic-management-of-benign-esophageal-ruptures-and-leaks
#4
REVIEW
Milena Di Leo, Roberta Maselli, Elisa Chiara Ferrara, Laura Poliani, Sameer Al Awadhi, Alessandro Repici
Esophageal leaks (EL) and ruptures (ER) are rare conditions associated with a high risk of mortality and morbidity. Historically, EL and ER have been surgically treated, but current treatment options also include conservative management and endoscopy. Over the last decades, interventional endoscopy has evolved as an effective and less invasive alternative to primary surgery in these cases. A variety of techniques are currently available to re-establish the continuity of the digestive tract, prevent or treat infection related to the leak/rupture, prevent further contamination, drain potential collections, and provide nutritional support...
May 15, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28503983/design-and-in-vitro-evaluation-of-tenofovir-loaded-vaginal-gels-for-the-prevention-of-hiv-infections
#5
Selin Seda Timur, Adem Şahin, Eren Aytekin, Naile Öztürk, Kerem Heybet Polat, Nurten Tezel, Reyhan Neslihan Gürsoy, Sema Çalış
Infection with the human immunodeficiency virus (HIV) is affecting women disproportionally with increasing incidence rates over the last decades. Tenofovir is one of the most commonly used antiretroviral agents, which belongs to the nucleoside/nucleotide reverse transcriptase inhibitor family, for the prevention of HIV acquisition. In scope of this study, a thermogelling system containing tenofovir - loaded chitosan nanoparticles for the controlled release of tenofovir was developed and characterized. The in vitro release studies have shown that the burst release effect was decreased to 27% with f-TFV CS NPs-Gel...
May 15, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28498164/functional-status-and-physical-impairments-of-adult-patients-infected-with-the-human-immunodeficiency-virus-admitted-to-hospital-a-scoping-review-protocol
#6
Ronel Roos, Heleen van Aswegen, Witness Mudzi
The objectives of this scoping review are to describe the physical impairments and subsequent level of function of adult individuals infected with the human immunodeficiency virus (HIV) admitted to an acute care hospital, determine the outcome measures used by rehabilitation professionals when evaluating said impairments and level of function in the population of interest, and identify the rehabilitation interventions offered to individuals while in hospital as a means of addressing these physical impairments and individuals' functional status...
May 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28498163/oral-hygiene-in-patients-with-chronic-obstructive-pulmonary-disease-a-scoping-review-protocol
#7
Preben U Pedersen, Lisbeth Uhrenfeldt, Palle Larsen
It is hypothesized that systematic oral hygiene may reduce airway infections in patients with chronic obstructive pulmonary disease (COPD). Before considering doing a systematic review, a scoping review is necessary to explore and map literature on the subject and identify which interventions have been carried out, if there is relevant literature available for a systematic review, or if further research should be initiated.The objective of this scoping review is to comprehensively identify and describe qualitative or quantitative literature reporting of non-invasive interventions that have been carried out to improve oral hygiene and relieve and/or reduce respiratory tract infections, exacerbation and/or hospital readmission in patients with diagnosed with COPD...
May 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28498161/pediatric-tonsillectomy-quality-of-life-assessment-instruments-a-scoping-review-protocol
#8
Stephen S Kao, Micah D J Peters, Eng H Ooi
The objective of this scoping review is to investigate quality of life (QoL) questionnaires available to pediatric patients following tonsillectomies with or without adenoidectomies for chronic infection or sleep-disordered breathing (SDB). The scoping review will aim to map the components of each QoL questionnaire assessed including frequency of use, age parameters, respondent, domains assessed, format and psychometric properties. Questionnaire format will be summarized into respondent and administrator burden by identifying the number of questions present, scale utilized and time to completion...
May 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28487456/deriving-literature-based-benchmarks-for-surgical-complications-in-high-income-countries-a-protocol-for-a-systematic-review-and-meta-analysis
#9
Mary E Brindle, Derek J Roberts, Oluwatomilayo Daodu, Alex Bernard Haynes, Christy Cauley, Elijah Dixon, Claude La Flamme, Paul Bain, William Berry
INTRODUCTION: To improve surgical safety, health systems must identify preventable adverse outcomes and measure changes in these outcomes in response to quality improvement initiatives. This requires understanding of the scope and limitations of available population-level data. To derive literature-based summary estimates of benchmarks of care, we will systematically review and meta-analyse rates of postoperative complications associated with several common and/or high-risk operations performed in five high-income countries (HICs)...
May 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28476111/single-use-and-conventional-bronchoscopes-for-broncho-alveolar-lavage-bal-in-research-a-comparative-study-nct-02515591
#10
Seher Raza Zaidi, Andrea M Collins, Elena Mitsi, Jesús Reiné, Kayleigh Davies, Angela D Wright, Jessica Owugha, Richard Fitzgerald, Amitava Ganguli, Stephen B Gordon, Daniela Mulari Ferreira, Jamie Rylance
BACKGROUND: Broncho alveolar lavage (BAL) is widely used for investigative research to study innate, cellular and humoral immune responses, and in early phase drug trials. Conventional (multiple use) flexible bronchoscopes have time and monetary costs associated with cleaning, and carries a small risk of cross infection. Single use bronchoscopes may provide an alternative, but have not been evaluated in this context. METHODS: Healthy volunteers underwent bronchoscopy at a day-case clinical research unit using the Ambu® aScope(TM) single-use flexible intubation bronchoscope...
May 5, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28461161/recommendations-for-the-management-of-comorbidity-in-patients-with-axial-spondyloarthritis-in-clinical-practice
#11
Carlos González, Rafael Curbelo Rodríguez, Juan Carlos Torre-Alonso, Eduardo Collantes, Santos Castañeda, M Victoria Hernández, Ana Urruticoechea-Arana, Juan Carlos Nieto-González, Javier García, Miguel Ángel Abad, Julio Ramírez, Carmen Suárez, Regina Dalmau, Maria Dolores Martín-Arranz, Leticia León, Juan Carlos Hermosa, Juan Carlos Obaya, Teresa Otón, Loreto Carmona
OBJECTIVES: To identify priorities among comorbidities in axial spondyloarthritis (AxSpA) and recommend how to follow them from an eminently practical perspective. METHODS: A multidisciplinary group was selected (10 rheumatologists-six of them experts in AxSpA-, 2 general practitioners, an internist, a cardiologist, a gastroenterologist and a psychologist). In a first discussion meeting, the scope and users were established and a list of comorbidities was voted based on frequency and impact...
April 28, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28455254/effects-of-chrysanthemum-indicum-polysaccharide-and-its-phosphate-on-anti-duck-hepatitis-a-virus-and-alleviating-hepatic-injury
#12
Ke Ming, Yun Chen, Jintong Shi, Jingjing Yang, Fangke Yao, Hongu Du, Wei Zhang, Jingying Bai, Jiaguo Liu, Deyun Wang, Yuanliang Hu, Yi Wu
To explore new effective anti-duck hepatitis A virus drugs, Chrysanthemum indicum polysaccharide (CIPS) was phosphorylation modified using STMP-STPP method, and phosphorylated Chrysanthemum indicum polysaccharide (pCIPS) was obtained. Characteristic absorption peaks were observed in pCIPS using IR spectrum, suggested that CIPS was successfully modified. In addition, field emission scanning electron micro-scope (FE-SEM) was used to observe the polysaccharides' surface features. In vitro, we found that the survival rate of DHAV-infected hepatocytes increased after the two drugs treatment, indicated that the two drugs possess good anti-DHAV activity...
April 26, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28443518/limitations-of-current-therapeutic-options-possible-drug-targets-and-scope-of-natural-products-in-control-of-leishmaniasis
#13
Neeraj Tiwari, Mallikarjuna Rao Gedda, Vinod K Tiwari, Surya P Singh, Rakesh K Singh
Soon after the identification of Leishmania parasites,the pentavalent antimony compounds have been the mainstay to treat leishmanial infections, worldwide. These compounds were also considered true antileishmanial but the growing incidences of resistance have forced clinicians to use other options. However, due to unavailability of antileishmanial compounds, few drugs like pentamidine (antimicrobial), amphotericin B (antifungal) or miltefosine (antitumor) agents, which are associated with serious side effects, are currently being used...
April 24, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28442456/the-malaria-system-microapp-a-new-mobile-device-based-tool-for-malaria-diagnosis
#14
Allisson Dantas Oliveira, Clara Prats, Mateu Espasa, Francesc Zarzuela Serrat, Cristina Montañola Sales, Aroa Silgado, Daniel Lopez Codina, Mercia Eliane Arruda, Jordi Gomez I Prat, Jones Albuquerque
BACKGROUND: Malaria is a public health problem that affects remote areas worldwide. Climate change has contributed to the problem by allowing for the survival of Anopheles in previously uninhabited areas. As such, several groups have made developing news systems for the automated diagnosis of malaria a priority. OBJECTIVE: The objective of this study was to develop a new, automated, mobile device-based diagnostic system for malaria. The system uses Giemsa-stained peripheral blood samples combined with light microscopy to identify the Plasmodium falciparum species in the ring stage of development...
April 25, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28418265/global-health-resource-utilization-associated-with-pacemaker-complications
#15
Catherine Waweru, Anna Steenrod, Claudia Wolff, Simon Eggington, David Jay Wright, Kathleen W Wyrwich
AIM: To estimate health resource utilization (HRU) associated with the management of pacemaker complications in various healthcare systems. METHODS: Electrophysiologists (EPs) from four geographical regions (Western Europe, Australia, Japan, and North America) were invited to participate. Survey questions focused on HRU in the management of three chronic pacemaker complications (i.e., pacemaker infections requiring extraction, lead fractures/insulation breaches requiring replacement, and upper extremity deep venous thrombosis [DVT])...
April 18, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28413631/screening-and-contact-precautions-a-survey-on-infection-control-measures-for-multidrug-resistant-bacteria-in-german-university-hospitals
#16
Lena M Biehl, Hartmut Bertz, Johannes Bogner, Ute-Helke Dobermann, Johanna Kessel, Carolin Krämer, Sebastian Lemmen, Marie von Lilienfeld-Toal, Silke Peter, Mathias W Pletz, Holger Rohde, Stefan Schmiedel, Sören Schubert, Andrew J Ullmann, Gerd Fätkenheuer, Maria J G T Vehreschild
To assess the scope of infection control measures for multidrug-resistant bacteria in high-risk settings, a survey among university hospitals was conducted. Fourteen professionals from 8 sites participated. Reported policies varied largely with respect to the types of wards conducting screening, sample types used for screening and implementation of contact precautions. This variability among sites highlights the need for an evidence-based consensus of current infection control policies.
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28411501/different-cross-protection-scopes-of-two-avian-influenza-h5n1-vaccines-against-infection-of-layer-chickens-with-a-heterologous-highly-pathogenic-virus
#17
Okti Nadia Poetri, Michiel Van Boven, Guus Koch, Arjan Stegeman, Ivo Claassen, I Wayan Wisaksana, Annemarie Bouma
Avian influenza (AI) virus strains vary in antigenicity, and antigenic differences between circulating field virus and vaccine virus will affect the effectiveness of vaccination of poultry. Antigenic relatedness can be assessed by measuring serological cross-reactivity using haemagglutination inhibition (HI) tests. Our study aims to determine the relation between antigenic relatedness expressed by the Archetti-Horsfall ratio, and reduction of virus transmission of highly pathogenic H5N1 AI strains among vaccinated layers...
April 8, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28400686/convergence-of-minds-for-better-patient-outcome-in-intensive-care-unit-infections
#18
Chand Wattal, Yash Javeri, Neeraj Goel, Debashish Dhar, Sonal Saxena, Sarman Singh, Jaswinder Kaur Oberoi, B K Rao, Purva Mathur, Vikas Manchanda, Vivek Nangia, Arti Kapil, Ashok Rattan, Supradip Ghosh, Omender Singh, Vinod Singh, Iqbal Kaur, Sanghamitra Datta, Sharmila Sen Gupta
BACKGROUND: There is emergence of resistance to the last-line antibiotics such as carbapenems in Intensive Care Units (ICUs), leaving little effective therapeutic options. Since there are no more newer antibiotics in the armamentarium in the near future, it has become imperative that we harness the interdisciplinary knowledge for the best clinical outcome of the patient. AIMS: The aim of the conference was to utilize the synergies between the clinical microbiologists and critical care specialists for better patient care and clinical outcome...
March 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28399780/triclosan-coated-sutures-for-the-prevention-of-surgical-site-infections-a-meta-analysis
#19
Athanasios A Konstantelias, Chrysi Stefania I Andriakopoulou, Sofia Mourgela
BACKGROUND: The scope of this article is to perform a meta-analysis of the studies that compare the use of triclosan-coated sutures (TCS) to uncoated sutures in prevention of surgical-site infections (SSIs). METHODS: A systematic search of randomized and non-randomized studies was carried out on Pubmed and Scopus databases until July 2016. RESULTS: The meta-analysis of 30 studies (19 randomized, 11 non-randomized; 15,385 procedures) gave evidence that TCS were associated with a lower risk of SSIs (risk ratio [RR] = 0...
June 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28380073/a-mixed-methods-approach-to-adapting-and-evaluating-the-functional-assessment-of-hiv-infection-fahi-swahili-version-for-use-with-low-literacy-populations
#20
Moses K Nyongesa, Antipa Sigilai, Amin S Hassan, Janet Thoya, Rachael Odhiambo, Fons J R Van de Vijver, Charles R J C Newton, Amina Abubakar
BACKGROUND: Despite bearing the largest HIV-related burden, little is known of the Health-Related Quality of Life (HRQoL) among people living with HIV in sub-Saharan Africa. One of the factors contributing to this gap in knowledge is the lack of culturally adapted and validated measures of HRQoL that are relevant for this setting. AIMS: We set out to adapt the Functional Assessment of HIV Infection (FAHI) Questionnaire, an HIV-specific measure of HRQoL, and evaluate its internal consistency and validity...
2017: PloS One
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