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https://www.readbyqxmd.com/read/27913469/can-we-make-a-better-match-or-mismatch-with-kir-genotyping
#1
Rohtesh S Mehta, Katayoun Rezvani
Natural killer (NK) cell function is regulated by a fine balance between numerous activating and inhibitory receptors, of which killer-cell immunoglobulin-like receptors (KIRs) are among the most polymorphic and comprehensively studied. KIRs allow NK cells to recognize downregulation or the absence of HLA class I molecules on target cells (known as missing-self), a phenomenon that is commonly observed in virally infected cells or cancer cells. Because KIR and HLA genes are located on different chromosomes, in an allogeneic environment such as after hematopoietic stem cell transplantation, donor NK cells that express an inhibitory KIR for an HLA class I molecule that is absent on recipient targets (KIR/KIR-ligand mismatch), can recognize and react to this missing self and mediate cytotoxicity...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27910750/antiretroviral-agents-looking-for-the-best-possible-chemotherapeutic-options-to-conquer-hiv
#2
Tahir Farooq, Arruje Hameed, Kanwal Rehman, Muhammad Ibrahim, Muhammad Imran Qadir, Muhammad Sajid Hamid Akash
For the last thirty years, ongoing efforts have revolutionized the antiretroviral therapy, which changed human immunodeficiency virus (HIV) infections from terrifying lethal diseases to chronic conditions. However, many challenges, like emergence of drug resistance, limited the scope of activity of currently existing anti-HIV agents. Quite often severe side effects and lifelong dependency are the major concerns of present era. All these issues have compelled the scientists to reconsider and refine the current therapies and also contemplate the pivotal priorities for the developments of novel therapeutic paradigms...
2016: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/27910193/use-of-organs-from-donors-with-bloodstream-infection-pneumonia-and-influenza-results-of-a-survey-of-infectious-diseases-practitioners
#3
Sanjay R Mehta, Cathy Logan, Camille N Kotton, Deepali Kumar, Saima Aslam
BACKGROUND: Potential organ donors may be admitted with an infection to an intensive care unit, or contract a nosocomial infection during their stay, increasing the risk of potential transmission to the recipient. Because of a lack of practice guidelines and large-scale data on this topic, we undertook a survey to assess the willingness of transplant infectious diseases (ID) physicians to accept such organs. METHODS: We performed a 10-question survey of ID providers from the American Society of Transplantation Infectious Disease Community of Practice to determine the scope of practice regarding acceptance of organs from donors with bloodstream infection, pneumonia, and influenza prior to organ procurement, as well as management of such infections following transplantation...
December 2, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/27876900/the-common-zoonotic-protozoal-diseases-causing-abortion
#4
REVIEW
Raafat Mohamed Shaapan
Toxoplasmosis, neosporosis, sarcosporidiosis (sarcocystosis) and trypanosomiasis are the common zoonotic protozoal diseases causing abortion which caused by single-celled protozoan parasites; Toxoplasma gondii, Neospora caninum, Sarcocystis spp and Trypanosoma evansi, respectively. Toxoplasmosis is generally considered the most important disease that causing abortion of both pregnant women and different female animals throughout the world, about third of human being population had antibodies against T. gondii...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27873264/current-trends-and-alternative-scenarios-in-ebv-research
#5
Janos Minarovits, Hans Helmut Niller
Epstein-Barr virus (EBV) infection is associated with several distinct hematological and epithelial malignancies, e.g., Burkitt lymphoma, Hodgkin lymphoma, nasopharyngeal carcinoma, gastric carcinoma, and others. The association with several malignant tumors of local and worldwide distribution makes EBV one of the most important tumor viruses. Furthermore, because EBV can cause posttransplant lymphoproliferative disease, transplant medicine has to deal with EBV as a major pathogenic virus second only to cytomegalovirus...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27867063/neonatal-listeriosis-in-the-uk-2004-2014
#6
Shari Sapuan, Christina Kortsalioudaki, Mark Anthony, John Chang, Nicholas D Embleton, Ruppa M Geethanath, Jim Gray, Anne Greenough, Mithilesh K Lal, Suzanne Luck, Santosh Pattnayak, Peter Reynolds, Allison B Russell, Timothy Scorrer, Mark Turner, Paul T Heath, Stefania Vergnano
OBJECTIVE: To define the clinical features and outcomes of neonatal listeriosis, and identify the maternal risk factors to seek scope for improvement. METHODS: Neonatal listeriosis was identified prospectively from a United Kingdom neonatal infection surveillance network (neonIN) between 2004 and 2014. The participating neonatal units completed a study-specific proforma. RESULTS: The incidence of neonatal listeriosis was 3.4 per 100,000 live births...
November 17, 2016: Journal of Infection
https://www.readbyqxmd.com/read/27866488/disposable-bronchoscope-model-for-simulating-endoscopic-reprocessing-and-surveillance-cultures
#7
Mohamed H Yassin, Rahman Hariri, Yasir Hamad, Juliet Ferrelli, Leeanna McKibben, Yohei Doi
BACKGROUND Endoscope-associated infections are reported despite following proper reprocessing methods. Microbiological testing can confirm the adequacy of endoscope reprocessing. Multiple controversies related to the method and interpretation of microbiological testing cultures have arisen that make their routine performance a complex target. OBJECTIVE We conducted a pilot study using disposable bronchoscopes (DBs) to simulate different reprocessing times and soaking times and to compare high-level disinfection versus ethylene oxide sterilization...
November 21, 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27856389/mini-laparoscopy-of-removal-partial-adnexae-at-the-time-of-hysterectomy
#8
António Gutierrez Setúbal, João Sequeira Alves, Olga Lavado, Joana Faria
STUDY OBJECTIVE: To describe our technique of mini laparoscopic adnexectomy or salpingectomy at the time of total laparoscopic hysterectomy DESIGN: Step-by-step video explanation of our technique SETTING: The advantages of laparoscopic surgery have been widely recognised in the past two decades: improved vision, exposure, reduction in operative trauma because of smaller incisions and more gentle tissue´s handling, that result in a faster postoperative recovery. The technology development has allowed the use of smaller caliber instruments while maintaining the high standard surgical performance...
November 14, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27847963/-challenge-of-neuroborreliosis
#9
A Spreer, S Rauer, H Wilking, V Fingerle
Lyme borreliosis is the most frequent tick-borne infection in Europe. It is a multisystemic disease affecting the skin, joints, heart, in rare cases the eyes and regularly the nervous system. Taking current clinical and microbiological guidelines into account, neuroborreliosis can in general be diagnosed and treated successfully. An appropriate guideline-conform antibiotic treatment is effective and in most cases recovery from acute neuroborreliosis is complete. Nevertheless, the evidence base regarding pharmacological treatment needs reform and improvement...
November 15, 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27846911/biology-distribution-and-control-of-anopheles-cellia-minimus-in-the-context-of-malaria-transmission-in-northeastern-india
#10
REVIEW
Vas Dev, Sylvie Manguin
Among six dominant mosquito vector species involved in malaria transmission in India, Anopheles minimus is a major species in northeast India and held responsible for focal disease outbreaks characterized by high-rise of Plasmodium falciparum infections and attributable death cases. It has been now genetically characterized that among the three-member species of the Minimus Complex spread in Asia, An. minimus (former species A) is prevalent in India including northeastern states and east-central state of Odisha...
November 15, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27827283/evaluation-of-the-assessment-and-documentation-of-chronic-wounds-in-residential-social-care-in-the-czech-republic
#11
S Saibertová, A Pokorná
OBJECTIVE: Accurate evaluation of non-healing, chronic wounds followed by the selection of an appropriate therapeutic strategy is a must for the foundation of health-care management. Assessment of non-healing chronic wounds in clinical practice in the Czech Republic is not standardised in acute care settings or in residential social care facilities. The aim of the study was to analyse the methods being used to assess non-healing, chronic wounds in residential social services in the Czech Republic, where more patients with chronic wounds are present because of the increasing incidence of wounds in old age...
November 2, 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27819701/-work-experience-and-seniority-in-health-care-vs-medical-students-knowledge-of-selected-hand-hygiene-procedures
#12
Anna Różańska, Jadwiga Wójkowska-Mach, Małgorzata Bulanda
BACKGROUND: Hand hygiene (HH) is the most important element of infection prevention. The aim of the study was to analyze the level of HH knowledge among medical students of Jagiellonian University Medical College in correlation with their clinical experience and the presence and extent of trainings in hospital hygiene prior to internships, as well as with HH practice among medical staff perceived by students. MATERIAL AND METHODS: The study was carried out in a group of 414 students from October to December, 2014...
2016: Medycyna Pracy
https://www.readbyqxmd.com/read/27817757/association-between-storage-interval-and-contamination-of-reprocessed-flexible-endoscopes-in-a-pediatric-gastrointestinal-procedural-unit
#13
Patricia Scanlon, Kathleen Flaherty, Erik A Reilly, Ellen G Barth, Gail Potter-Bynoe, Jeff Cardini, Ann Marie Riley, Alexander J McAdam, Thomas J Sandora
OBJECTIVE The maximum safe storage interval after endoscope reprocessing remains unknown. We assessed the association between storage interval and endoscope contamination to evaluate the need for scope reprocessing prior to use. METHODS We conducted a study in 2 phases. In phase 1, we cultured 9 gastrointestinal (GI) endoscopes that had been stored for at least 7 days since reprocessing. Each scope was cultured in 3 places: external surfaces of hand piece, insertion tube, and internal channels. In phase 2, after reprocessing these scopes, we hung and cultured them prospectively in a similar fashion at 1-, 2-, 4-, 6-, and 8-week intervals without patient use...
November 7, 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27810495/psoriasis-risk-snps-and-their-association-with-hiv-1-control
#14
Joanne Nititham, Rashmi Gupta, Xue Zeng, Wendy Hartogensis, Douglas F Nixon, Steven G Deeks, Frederick M Hecht, Wilson Liao
Human evolution has resulted in selection for genetic polymorphisms beneficial in the defense against pathogens. However, such polymorphisms may have the potential to heighten the risk of autoimmune disease. Here, we investigated whether psoriasis-associated single nucleotide polymorphisms influence host control of HIV-1 infection. We studied psoriasis and viral immune response variants in three HIV-positive cohorts: (1) HIV-1 controllers and non-controllers in the Study of the Consequences of the Protease Inhibitor Era (SCOPE) cohort (n=366), (2) Individuals with primary HIV infection in the Options cohort (n=675), and (3) HIV-positive injection drug users from the Urban Health Study (UHS) (n=987)...
October 31, 2016: Human Immunology
https://www.readbyqxmd.com/read/27804058/the-association-of-medication-use-with-clearance-or-persistence-of-oral-hpv-infection
#15
Jennifer O Lam, Elizabeth A Sugar, Ross D Cranston, Kathleen M Weber, Robert D Burk, Dorothy J Wiley, Susheel Reddy, Joseph B Margolick, Howard D Strickler, Alicia Wentz, Lisa Jacobson, Christian L Coles, Jay H Bream, Anne F Rositch, Yingshi Guo, Weihong Xiao, Maura L Gillison, Gypsyamber D'Souza
PURPOSE: Persistent oral human papillomavirus (HPV) infection increases risk for oropharyngeal carcinoma, and people living with HIV have higher rates of oral HPV infection and related cancers. Some prescription medications have immunomodulatory effects, but the impact of medication use on oral HPV natural history is unknown. METHODS: Scope(®) oral rinse-and-gargle samples were collected semi-annually from 1,666 participants and tested for 37 types of oral HPV DNA using PCR; 594 HPV-infected participants with 1,358 type-specific oral HPV infections were identified...
November 1, 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/27798010/why-do-general-practitioners-prescribe-antibiotics-for-upper-respiratory-tract-infections-to-meet-patient-expectations-a-mixed-methods-study
#16
Stephanie Fletcher-Lartey, Melissa Yee, Christina Gaarslev, Rabia Khan
OBJECTIVES: To describe the role patient expectations play in general practitioners (GPs) antibiotic prescribing for upper respiratory tract infections (URTI). METHODS: Concurrent explanatory mixed methods approach using a cross-sectional survey and semistructured interviews. SETTINGS: Primary care GPs in Australia. PARTICIPANTS: 584 GPs (response rate of 23.6%) completed the cross-sectional survey. 32 GPs were interviewed individually...
October 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27783679/vector-competence-of-american-mosquitoes-for-three-strains-of-zika-virus
#17
James Weger-Lucarelli, Claudia Rückert, Nunya Chotiwan, Chilinh Nguyen, Selene M Garcia Luna, Joseph R Fauver, Brian D Foy, Rushika Perera, William C Black, Rebekah C Kading, Gregory D Ebel
In 2015, Zika virus (ZIKV; Flaviviridae; Flavivirus) emerged in the Americas, causing millions of infections in dozens of countries. The rapid spread of the virus and the association with disease outcomes such as Guillain-Barré syndrome and microcephaly make understanding transmission dynamics essential. Currently, there are no reports of vector competence (VC) of American mosquitoes for ZIKV isolates from the Americas. Further, it is not clear whether ZIKV strains from other genetic lineages can be transmitted by American Aedes aegypti populations, and whether the scope of the current epidemic is in part facilitated by viral factors such as enhanced replicative fitness or increased vector competence...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27778427/drug-hypersensitivity-syndrome-with-prolonged-course-complicated-by-parvovirus-infection
#18
Carrie C Coughlin, Melinda V Jen, Markus D Boos
Drug hypersensitivity syndrome (DHS) is a severe medication reaction involving multiple organ systems that is characterized by rash, lymphadenopathy, and laboratory aberrations, including hepatic enzyme changes. Viral reactivation in the setting of DHS can significantly affect the course of disease. We report two children in whom parvovirus infection prolonged and complicated their course of DHS. Most other DHS-complicating viruses are herpesviruses; this report broadens the scope of DHS-modifying infections to include activation of Parvoviridae...
October 25, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27777755/serious-electronic-games-as-behavioural-change-interventions-in-healthcare-associated-infections-and-infection-prevention-and-control-a-scoping-review-of-the-literature-and-future-directions
#19
Enrique Castro-Sánchez, Yiannis Kyratsis, Michiyo Iwami, Timothy M Rawson, Alison H Holmes
BACKGROUND: The uptake of improvement initiatives in infection prevention and control (IPC) has often proven challenging. Innovative interventions such as 'serious games' have been proposed in other areas to educate and help clinicians adopt optimal behaviours. There is limited evidence about the application and evaluation of serious games in IPC. The purposes of the study were: a) to synthesise research evidence on the use of serious games in IPC to support healthcare workers' behaviour change and best practice learning; and b) to identify gaps across the formulation and evaluation of serious games in IPC...
2016: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/27774576/neurocysticercosis-a-review-on-status-in-india-management-and-current-therapeutic-interventions
#20
Rumana Ahmad, Tahmeena Khan, Bilal Ahmad, Aparna Misra, Anil K Balapure
Tapeworms (cestodes) are segmented flatworms responsible for causing diseases that may prove fatal and difficult to treat in the absence of proper treatment and efficient drugs. Neurocysticercosis (NCC) is a common parasitic infection of the central nervous system and a major contributor to epilepsy caused by the metacestode (larva) of the human tapeworm Taenia solium, characterized by a range of pathological symptoms including epileptic seizures, headaches, and hydrocephalus. Cysticercosis is considered as a "biological imprint" of the socioeconomic development of a community in general and a country in particular...
October 24, 2016: Parasitology Research
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