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https://www.readbyqxmd.com/read/28944826/macc%C3%A2-1-antibody-target-therapy-suppresses-growth-and-migration-of-non%C3%A2-small-cell-lung-cancer
#1
Woda Shi, Jianxiang Song, Wencai Wang, Yajun Zhang, Shiying Zheng
Non‑small‑cell lung cancer (NSCLC) accounts for ~80% of human lung cancers that result in mortalities worldwide. Metastasis‑associated in colon cancer‑1 (MACC‑1) has been demonstrated to be significantly expressed in cases of NSCLC and promotes tumor cell migration and metastasis through transactivation of the metastasis‑inducing hepatocyte growth factor/MET proto‑gene, receptor tyrosine kinase (HGF/MET) signaling pathway. The present study constructed a chimeric antibody (Chanti‑MACC‑1) targeting MACC‑1 and investigated its potential as a molecular therapeutic target in the treatment of NSCLC therapy...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944686/remission-of-chronic-headache-rates-potential-predictors-and-the-role-of-medication-follow-up-results-of-the-german-headache-consortium-ghc-study
#2
Verena Henning, Zaza Katsarava, Mark Obermann, Susanne Moebus, Sara Schramm
Objectives To estimate remission rates of chronic headache (CH), focusing on potential predictors of headache remission and medication. Methods We used data from the longitudinal population-based German Headache Consortium (GHC) Study (n = 9,944, 18-65 years). Validated questionnaires were used at baseline (t0, 2003-2007, response rate: 55.2%), first follow-up after 1.87 ± 0.39 years (t1, 37.2%) and second follow-up after 3.26 ± 0.60 years (t2, 38.8%) to assess headache type and frequency, use of analgesics and anti-migraine drugs, medication overuse, education, BMI, smoking and alcohol consumption...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28944501/synergistic-effects-of-interferon-beta-and-nivolumab-in-oral-mucosal-melanoma
#3
Takayuki Fusumae, Koji Kamiya, Binluen Chiang, Hirofumi Okada, Naomi Nakano, Takeo Maekawa, Mayumi Komine, Satoru Murata, Mamitaro Ohtsuki
Mucosal melanoma is a rare aggressive cancer with a very poor prognosis. Clinical and pathological characteristics of mucosal melanoma differ from those of cutaneous melanoma and there are no established management guidelines for mucosal melanoma. Complete surgical excision is one of the most effective treatments for localized lesions, while targeted therapies and immunotherapies, such as monoclonal antibodies that target cytotoxic T-lymphocyte-associated molecule-4, and the programmed death (PD)-1/PD-ligand 1 pathway inhibitors, are treatment options for unresectable or metastatic lesions...
September 25, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28944397/chronic-myeloid-leukemia-the-promise-of-tyrosine-kinase-inhibitor-discontinuation
#4
REVIEW
Ravi Kishore Narra, Kathryn E Flynn, Ehab Atallah
Some believe that tyrosine kinase inhibitor (TKI) therapy is as close to perfect as it gets in oncologic therapy. Patients diagnosed with chronic myeloid leukemia (CML) are treated with a daily oral therapy, through which most achieve remission. TKI therapy is not associated with classic chemotherapy side effects, and most patients are able to resume their normal activities of daily living. Moreover, recent data has demonstrated that CML does not affect the life expectancy of patients whose disease is well controlled with a TKI...
September 25, 2017: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/28944312/the-structure-of-personality-disorders-within-a-depressed-sample-implications-for-personalizing-treatment
#5
Joanna M Berg, Jamie C Kennedy, Boadie W Dunlop, Cynthia L Ramirez, Lindsay M Stewart, Charles B Nemeroff, Helen S Mayberg, W Edward Craighead
BACKGROUND: Personality disorders (PDs) and major depressive disorder (MDD) are both significant public health burdens. They are frequently comorbid, and this comorbidity predicts poorer treatment outcomes and lower maintenance of treatment effects. Although there is growing consensus on the structure of personality pathology in non-depressed individuals, there is limited research on the structure of personality pathology in individuals experiencing MDD. METHOD: As part of the Predictors of Remission in Depression to Individual and Combined Treatment (PReDICT) randomized controlled trial, 192 treatment-naïve subjects meeting DSM-IV-TR criteria for MDD completed the International Personality Disorder Examination (IPDE)...
March 2017: Pers Med Psychiatr
https://www.readbyqxmd.com/read/28944148/metastatic-neuroendocrine-tumor-of-the-esophagus-with-features-of-medullary-thyroid-carcinoma
#6
Raymond M Fertig, Adam Alperstein, Carlos Diaz, Kyle D Klingbeil, Sameera S Vangara, Ryosuke Misawa, Jennifer Reed, Sudeep Gaudi
A 41-year-old female presented with a pedunculated mass in the upper esophagus and bilateral lymphadenopathy. Biopsies suggested a neuroendocrine tumor, possibly carcinoid, and ensuing imaging revealed cervical lymph node metastases. The esophageal mass was removed endoscopically and discovered by pathologists to closely resemble medullary thyroid carcinoma (MTC) on immunohistochemistry staining. Following surgery, further work up demonstrated very high serum calcitonin levels, suggestive of medullary thyroid carcinoma, however the thyroid gland was normal on ultrasound...
August 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/28943556/two-cases-of-central-diabetes-insipidus-in-refractory-antineutrophil-cytoplasmic-antibody-associated-vasculitis
#7
Keiji Ohashi, Michiko Morishita, Haruki Watanabe, Ken-Ei Sada, Takayuki Katsuyama, Yoshia Miyawaki, Eri Katsuyama, Mariko Narazaki, Noriko Tatebe, Katsue Watanabe, Tomoko Kawabata, Jun Wada
We herein describe two cases of refractory antineutrophil cytoplasmic antibody-associated vasculitis (AAV) complicated with diabetes insipidus (DI) possibly related to hypertrophic pachymeningitis (HP). One patient had microscopic polyangiitis and HP, which were refractory to cyclophosphamide, azathioprine, rituximab, mycophenolate mofetil (MMF), and mizoribine. Remission was finally achieved with the use of etanercept, but DI occurred 5 years later. The other patient had granulomatosis with polyangiitis, which that was refractory to cyclophosphamide, methotrexate, MMF, and rituximab...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28942809/reduced-inferior-and-orbital-frontal-thickness-in-adolescent-bulimia-nervosa-persists-over-two-year-follow-up
#8
Marilyn Cyr, Daniel C Kopala-Sibley, Seonjoo Lee, Chen Chen, Mihaela Stefan, Martine Fontaine, Kate Terranova, Laura A Berner, Rachel Marsh
OBJECTIVE: Cross-sectional data suggest functional and anatomical disturbances in inferior and orbital frontal regions in bulimia nervosa (BN). Using longitudinal data, we investigated whether reduced cortical thickness (CT) in these regions arises early and persists over adolescence in BN, independent of symptom remission, and whether CT reductions are markers of BN symptoms. METHOD: A total of 33 adolescent females with BN symptoms (BN or other specified feeding or eating disorder) and 28 healthy adolescents participated in this study...
October 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28942805/randomized-clinical-trial-of-dialectical-behavior-therapy-for-preadolescent-children-with-disruptive-mood-dysregulation-disorder-feasibility-and-outcomes
#9
Francheska Perepletchikova, Donald Nathanson, Seth R Axelrod, Caitlin Merrill, Amy Walker, Meredith Grossman, James Rebeta, Lawrence Scahill, Joan Kaufman, Barbara Flye, Elizabeth Mauer, John Walkup
OBJECTIVE: Persistent irritability and behavior outbursts in disruptive mood dysregulation disorder (DMDD) are associated with severe impairment in childhood and with negative adolescent and adult outcomes. There are no empirically established treatments for DMDD. This study examined the feasibility and preliminary efficacy of dialectical behavior therapy adapted for preadolescent children (DBT-C) with DMDD. METHOD: Children 7 to 12 years old with DMDD (N = 43) were randomly assigned 1:1 to DBT-C or treatment as usual (TAU)...
October 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28942708/laparoscopic-roux-en-y-gastric-bypass-in-elderly-patients-60%C3%A2-years-or-older-a-meta-analysis-of-comparative-studies
#10
S Giordano, M Victorzon
BACKGROUND AND AIMS: Elderly patient might experience an increased risk of complications after laparoscopic Roux-en-Y gastric bypass. We aimed to perform a meta-analysis of comparative studies on this issue in patients aged 60 years or older. MATERIAL AND METHODS: A systematic literature search was performed. Medline, Cochrane Library, Embase, Scopus, and Google Scholar were searched until July 2016 for studies on outcomes of laparoscopic Roux-en-Y gastric bypass in elderly versus younger patients...
September 1, 2017: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/28942410/when-all-else-fails-supervised-treatment-in-outpatient-for-schizophrenia-stops
#11
Huey Jing Renee Tan
This was about a case of a patient requiring admission to psychiatry ward twice a year for relapse schizophrenia due to medication non-compliance. Medication adherence was previously monitored by her husband. However, following the death of her husband, she stopped treatment. The lack of insight and poor family support further contributed to her relapse. She presented with positive and negative symptoms of schizophrenia during her relapse, neglecting her hygiene and oral intake. She was also found to have anaemia as a result of poor diet when she was in relapse...
September 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28942074/immunosuppression-for-the-uveitides
#12
REVIEW
Douglas A Jabs
The uveitides are a collection of more than 30 diseases characterized by intraocular inflammation. Many cases of juvenile idiopathic arthritis-associated uveitis, many cases of intermediate uveitis, and most cases of posterior and panuveitides requiring treatment are treated with corticosteroids and immunosuppression. Disease-specific, time-updated modeling of clinical data for several uveitides suggests superior prevention of ocular complications and visual outcomes with immunosuppression. These studies also suggest that oral corticosteroids at doses low enough for safe long-term therapy (i...
September 20, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28942016/positron-emission-tomography-based-assessment-of-metabolic-tumor-volume-predicts-survival-after-autologous-hematopoietic-cell-transplantation-for-hodgkin-lymphoma
#13
Vít Procházka, Rakhee S Gawande, Zuzan Cayci, Jerry W Froelich, Qing Cao, Chris Wilke, Kathryn Dusenbery, Daniel J Weisdorf, Veronika Bachanova
Autologous hematopoietic cell transplantation (AHCT) is curative for 60% of patients with relapsed or refractory Hodgkin lymphoma (R/R HL). A more precise assessment of the depth of remission prior to AHCT may help to identify patients likely to benefit from AHCT. We aimed to determine whether PET-based quantitative parameters of total metabolic tumor volume (TMTV), total lesion glycolysis (TLG), and maximal standardized uptake volume (SUVmax) measured prior to AHCT predict progression-free survival (PFS) after transplant...
September 20, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28941963/effects-of-androgen-deprivation-therapy-on-pain-perception-quality-of-life-and-depression-in-men-with-prostate-cancer
#14
Thiago Gagliano-Jucá, Thomas G Travison, Paul L Nguyen, Philip W Kantoff, Mary-Ellen Taplin, Adam S Kibel, Robert Manley, Kathleen Hally, Richelle Bearup, Yusnie M Beleva, Grace Huang, Robert R Edwards, Shehzad Basaria
CONTEXT: Previous animal and human research suggests that testosterone has anti-nociceptive properties. Castration in male rodents increases pain perception which is reversed by testosterone replacement. Pain perception also improves in hypogonadal men with testosterone therapy. However, it remains unclear whether androgen deprivation therapy (ADT) in men with prostate cancer (PCa) is associated with an increase in pain perception. METHODS: Thirty-seven men with PCa about to undergo ADT with leuprolide acetate (ADT group) were followed prospectively for 6 months to evaluate changes in clinical and experimental pain...
September 20, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28941928/sequential-actions-of-immune-effector-cells-induced-by-viral-activation-of-dendritic-cells-to-eliminate-murine-neuroblastoma
#15
Naonori Kawakubo, Sakura Tanaka, Yoshiaki Kinoshita, Tatsuro Tajiri, Yoshikazu Yonemitsu, Tomoaki Taguchi
PURPOSE: In preclinical trails, we reported the antitumor effect of dendritic cells activated with Sendai virus (rSeV/DC) combined with γ-irradiation against neuroblastoma. However, what kind of effector cells for the combined therapy were used to show the antitumor effect was unclear. In this study, we performed radiation and rSeV/DC therapy in vivo and examined the effector cells involved. METHODS: Dendritic cells were cultured from bone marrow cells, activated with SeV and administered intratumorally at 10(6) weekly for 3weeks...
August 26, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28941711/persistent-elevation-of-plasma-thrombopoietin-levels-after-treatment-in-severe-aplastic-anemia
#16
Xin Zhao, Xingmin Feng, Zhijie Wu, Thomas Winkler, Ronan Desmond, Matthew Olnes, Bogdan Dumitriu, Danielle M Townsley, Cynthia E Dunbar, Neal S Young
Although hematopoietic growth factors are at high levels in aplastic anemia (AA) patients, little is known about their dynamic change over time post treatment. We examined plasma concentrations of hematopoietic growth factors sequentially in 55 severe AA patients (45 treatment-naïve patients who had received immunosuppressive therapy (IST) or IST and eltrombopag; 10 IST-refractory patients who had received eltrombopag only), focusing on thrombopoietin (TPO). TPO concentrations were much higher than normal range in patients before treatment, then decreased in responders but not in non-responders...
September 20, 2017: Experimental Hematology
https://www.readbyqxmd.com/read/28941627/-childhood-steroid-dependent-idiopathic-nephrotic-syndrome-predictive-factors-for-the-need-of-immunosuppressive-treatment
#17
M Golay, A Douillard, N Nagot, M Fila, L Ichay, F Dalla Vale, J Tenenbaum, D Morin
BACKGROUND AND AIMS: More than half of the children with idiopathic nephrotic syndrome become steroid-dependent (or frequent relapsers) and will later require the use of complementary treatment aiming to reduce steroids' side effects and to limit the number of proteinuria relapses. It appears important to identify these children as early as possible in order to adapt their treatment. The aim of this study was to analyze the population of children, under 18 years of age, diagnosed between 1/01/2000 and 31/05/2015 with an idiopathic nephrotic syndrome and followed at the Montpellier University Hospital to search for criteria predictive of steroid-sparing agent use...
September 20, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28941267/successful-therapy-of-excoriated-acne-with-nd-yag-laser-a-case-report
#18
Vesna Tlaker
Excoriated acne is a difficult challenge in daily practice. Patients generally fail to follow the most important measure: not to "clean" and manipulate their lesions. Because the literature tends to emphasize the mental aspect of this condition, patients with excoriated acne may be quickly classified as psychosomatic or even psychiatric cases, and dermatologists may be overlooking opportunities to help. This report presents the case of a young woman with excoriated acne and anorexia nervosa, treated with a combination of 1,064 nm Nd:YAG laser, standard acne topical therapy, and a reassuring, non-judgmental approach...
September 2017: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/28941147/timing-and-impact-of-decisions-to-adjust-disease-modifying-antirheumatic-drug-therapy-for-rheumatoid-arthritis-patients-with-active-disease
#19
Yomei Shaw, Chung-Chou H Chang, Marc C Levesque, Julie M Donohue, Kaleb Michaud, Mark S Roberts
OBJECTIVE: Guidelines recommend that rheumatoid arthritis (RA) patients with moderate to high disease activity (MHDAS) adjust disease-modifying antirheumatic drug (DMARD) therapy at least every 3 months until reaching low disease activity or remission (LDAS). We examined how quickly RA patients with MHDAS adjust DMARD therapy in clinical practice, and whether those who adjust DMARDs within 90 days in response to MHDAS reach LDAS sooner. METHODS: We identified RA patients with MHDAS in the University of Pittsburgh Rheumatoid Arthritis Comparative Effectiveness Research (RACER) registry, and conducted a competing risks regression on time to DMARD therapy adjustment and a Cox regression on time to LDAS...
September 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28941098/comparing-three-year-extension-of-early-intervention-service-to-regular-care-following-two-years-of-early-intervention-service-in-first-episode-psychosis-a-randomized-single-blind-clinical-trial
#20
Ashok Malla, Ridha Joober, Srividya Iyer, Ross Norman, Norbert Schmitz, Thomas Brown, Danyael Lutgens, Eric Jarvis, Howard C Margolese, Nicola Casacalenda, Amal Abdel-Baki, Eric Latimer, Sally Mustafa, Sherezad Abadi
This study aimed to determine if, following two years of early intervention service for first-episode psychosis, three-year extension of that service was superior to three years of regular care. We conducted a randomized single blind clinical trial using an urn randomization balanced for gender and substance abuse. Participants were recruited from early intervention service clinics in Montreal. Patients (N=220), 18-35 years old, were randomized to an extension of early intervention service (EEIS; N=110) or to regular care (N=110)...
October 2017: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
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