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https://www.readbyqxmd.com/read/28400148/accelerated-re-epithelialization-of-partial-thickness-skin-wounds-by-a-topical-betulin-gel-results-of-a-randomized-phase-iii-clinical-trials-program
#1
Juan P Barret, Fred Podmelle, Břetislav Lipový, Hans-Oliver Rennekampff, Hauke Schumann, Agnes Schwieger-Briel, Tobias R Zahn, Hans-Robert Metelmann
The clinical significance of timely re-epithelialization is obvious in burn care, since delayed wound closure is enhancing the risk of wound site infection and extensive scarring. Topical treatments that accelerate wound healing are urgently needed to reduce these sequelae. Evidence from preliminary studies suggests that betulin can accelerate the healing of different types of wounds, including second degree burns and split-thickness skin graft wounds. The goal of this combined study program consisting of two randomized phase III clinical trials in parallel is to evaluate whether a topical betulin gel (TBG) is accelerating re-epithelialization of split-thickness skin graft (STSG) donor site wounds compared to standard of care...
April 8, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28379607/randomized-clinical-trial-of-autologous-skin-cell-suspension-for-accelerating-re-epithelialization-of-split-thickness-donor-sites
#2
Z Hu, D Guo, P Liu, X Cao, S Li, J Zhu, B Tang
BACKGROUND: Split-thickness skin graft (STSG) is used frequently, but may result in complications at the donor site. Rapid healing of donor-site wounds is critical to relieving morbidity. This study investigated whether autologous skin cell suspension could improve healing of STSG donor-site wounds. METHODS: Between September 2014 and February 2016, patients requiring STSGs were randomized to receive autologous skin cell suspension plus hydrocolloid dressings (experimental group) or hydrocolloid dressings alone (control group) for the donor site...
April 5, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28369013/wound-healing-from-dermal-grafts-containing-cd34-cells-is-comparable-to-split-thickness-skin-micrografts
#3
Kristo Nuutila, Mansher Singh, Carla Kruse, Elof Eriksson
BACKGROUND: Epidermal stem cells present in the skin appendages of the dermis might be crucial in wound healing. In this study we located these cells in the dermis and evaluated their contribution to full-thickness wound healing in a porcine model. METHODS: Four sequentially deeper 0.35mm thick skin grafts were harvested from the same donor site going down to 1.4 mm in depth (Layers 1-4). The layers were minced to 0.8 x 0.8 x 0.35 mm micrografts and transplanted (1:2) onto full-thickness porcine wounds...
March 31, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28326683/restoring-full-thickness-defects-with-spray-skin-in-conjunction-with-dermal-regenerate-template-and-split-thickness-skin-grafting-a-pilot-study
#4
Daniel Hammer, Juan L Rendon, Jennifer Sabino, Kerry Latham, Mark E Fleming, Ian L Valerio
Complex, full-thickness soft tissue defects secondary to large burns, trauma and war-related injuries continue to challenge reconstructive surgeons. To achieve positive surgical outcomes in these patient populations, novel approaches are needed to restore the functional, protective and aesthetic properties of skin. Herein, we provide the first report describing the staged use of a dermal regenerate template (DRT) with a spray-on epidermal regenerative modality (spray skin) in addition to autologous split-thickness skin grafting (STSG) in non-burn trauma and compare these results with those of patients treated with DRT and STSG alone...
March 22, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28325054/-the-use-of-negative-pressure-wound-therapy-in-the-fixation-of-split-thickness-skin-grafts
#5
J Ulianko, J Janek, Ľ Laca
INTRODUCTION: Negative pressure wound therapy is one of the latest methods of dealing with complicated healing wounds. It promotes granulation, mechanically attracts the edges of the wound, removes secretions, reduces the number of bacteria in the wound and reduces swelling. In addition to its use to start and enhance the healing process, this method is also important in the fixation of split-thickness skin grafts in non-ideal conditions. The goal of this article is to establish basic indications for negative pressure fixation of meshed split-thickness skin grafts in non-ideal conditions in the wound and to assess the impact of contamination of wounds on engraftment using vacuum therapy...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28304144/efficacy-of-dermal-substitute-on-deep-dermal-to-full-thickness-burn-injury-a-systematic-review
#6
REVIEW
Winy Widjaja, Juen Tan, Peter K M Maitz
BACKGROUND: The study aims to systematically examine the efficacy of dermal regeneration templates (DRTs) in comparison to split thickness skin grafting (STSG) in the management of acute burn injuries post-excision and debridement. METHODS: Systematic literature search was conducted by two independent reviewers from the following databases: MEDLINE, EMBASE and Cochrane Library with selection criteria set a priori. Only randomized controlled trials (RCTs) were included...
March 17, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28299263/clinical-evaluation-of-coverage-of-open-wounds-polyglycolic-acid-sheet-with-fibrin-glue-spray-vs-split-thickness-skin
#7
Yumi Mochizuki, Hirofumi Tomioka, Fumihiko Tushima, Hiroaki Shimamoto, Hideaki Hirai, Yuu Oikawa, Hiroyuki Harada
PURPOSE: This study aimed to evaluate the coverage of oral wounds using either a polyglycolic acid (PGA) sheet or split-thickness skin grafting (STSG). MATERIALS AND METHODS: A total of 119 cases of wound coverage using a PGA sheet and fibrin glue spray as well as 132 cases of wound coverage cases using STSG were reviewed retrospectively. The site of the excision area, perioperative conditions, and postoperative functional problems were evaluated. RESULTS: The PGA group had significantly shorter operation time, earlier start of oral intake, and shorter hospitalization than the STSG group...
July 2016: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28258869/comparative-skin-evaluation-after-split-thickness-skin%C3%A2-grafts-using-2-different-acellular-dermal-matrices%C3%A2-to-cover-composite-forearm-defects
#8
Myung Chul Lee, Yong Jun Jang, In Sik Yun, Dae Hyun Lew, Won Jai Lee
PURPOSE: The combination of acellular dermal matrix (ADM) and split-thickness skin graft (STSG) has been widely adopted to overcome functional and cosmetic limitations of conventional STSG. In this study, we evaluated the efficacy of this combination using 2 types of ADM: cadaveric acellular dermal matrix (CDM) and bovine acellular dermal matrix (BDM). METHODS: We recruited 72 patients undergoing autologous STSG to cover radial forearm free flap donor sites. They were included in 1 of 3 therapeutic groups: group 1, STSG using CDM (n = 29); group 2, STSG using BDM (n = 20); and group 3, STSG only (n = 23)...
February 28, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28256293/use-of-a-home-vacuum-assisted-closure-device-in-the-burn-population-is-both-cost-effective-and-efficacious
#9
Oren P Mushin, Jarrod T Bogue, Mica D Esquenazi, Nicole Toscano, Derek E Bell
INTRODUCTION: The vacuum assisted closure device (VAC) improves wound-healing when utilized as a bolster to secure split thickness skin grafts (STSG). Patients typically remain hospitalized for VAC therapy; however, home VACs (hVAC) are now available. Limited studies examine burns treated with hVAC as a STSG bolster. METHOD: A retrospective study of records from an ABA verified regional burn center was conducted over 23 months. Patients included STSGs for burn. Data points included demographics, burn mechanism and location, graft characteristics, hospital length of stay (LOS), and time to heal...
February 27, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28096930/management-of-adult-concealed-penis-using-a-meshed-split-thickness-skin-graft
#10
Aaron Boonjindasup, Michael Pinsky, Carrie Stewart, Landon Trost, Abigail Chaffin, David Jansen, Wayne Hellstrom
INTRODUCTION: Concealed penis (CP) is a rare problem faced by urologists and plastic surgeons. CP occurs secondary to trauma, obesity, or infection. Surgical treatment is individualized and based on patient and provider variables. We aim to review our recent experience using meshed split-thickness skin grafting (STSG) for CP management. METHODS: A retrospective review was performed on patients who underwent STSG for CP at our institution. Records were reviewed for demographic, operative, and postoperative variables...
November 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28042321/pre-vascularization-enhances-therapeutic-effects-of-human-mesenchymal-stem-cell-sheets-in-full-thickness-skin-wound-repair
#11
Lei Chen, Qi Xing, Qiyi Zhai, Mitchell Tahtinen, Fei Zhou, Lili Chen, Yingbin Xu, Shaohai Qi, Feng Zhao
Split thickness skin graft (STSG) implantation is one of the standard therapies for full thickness wound repair when full thickness autologous skin grafts (FTG) or skin flap transplants are inapplicable. Combined transplantation of STSG with dermal substitute could enhance its therapeutic effects but the results remain unsatisfactory due to insufficient blood supply at early stages, which causes graft necrosis and fibrosis. Human mesenchymal stem cell (hMSC) sheets are capable of accelerating the wound healing process...
2017: Theranostics
https://www.readbyqxmd.com/read/28041749/minced-skin-grafting-for-promoting-epithelialization-of-the-donor-site-after-split-thickness-skin-grafting
#12
Toru Miyanaga, Yasuo Haseda, Akihiko Sakagami
It is important to minimize time to healing in the donor site after split-thickness skin grafting (STSG). It has been shown that minced skin grafting improves the appearance of the STSG donor site. The objective of this study was to investigate whether mincing the leftover harvested skin and grafting it back onto the donor site during minced grafting (MG) reduces healing time of the donor site. Normal healing time of the donor site after STSG is 10-20 days; therefore, healing time more than a month is abnormal...
December 29, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28028957/allogeneic-vs-autologous-skin-grafts-in-the-therapy-of-patients-with-burn-injuries-a-restrospective-open-label-clinical-study-with-pair-matching
#13
Diana Kitala, Marek Kawecki, Agnieszka Klama-Baryła, Wojciech Łabuś, Małgorzata Kraut, Justyna Glik, Ireneusz Ryszkiel, Marek P Kawecki, Mariusz Nowak
BACKGROUND: Early application of autologous skin may lead to the loss of split thickness skin graft due to unclarified wound bed. Allogeneic skin grafts are performed on patients with extensive burn injuries after escharotomy, tangential excisions and deep debridement for the purpose of stabilizing the general condition and reducing the scope of local complications. OBJECTIVES: The aim of this paper is to determine how the use of allografts improves the conditions for the intake of autografts in burns treatment, and how it accelerates wound healing in comparison to the autografts-only option...
September 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28012339/rare-nodular-malignant-melanoma-of-the-heel-in-the-caribbean-a-case-report
#14
Wayne A Warner, Vandana Devika Sookdeo, Srikanth Umakanthan, Kevin Sarran, Lemuel Pran, Maurice Fortuné, Wesley Greaves, Sharda Narinesingh, Dave Harnanan, Ravi Maharaj
INTRODUCTION: Malignant melanoma of the heel is a rare melanoma subtype with incidence rates that reflect the complex relationship between sun exposure at certain geographic locations, individual melanin levels and overall melanoma risk. It is oftentimes characterized by poor prognosis because of delays in presentation resulting in longitudinal tumor invasion, lymph node involvement and metastasis. PRESENTATION OF CASE: A 59-year-old woman was admitted to the Eric Williams Medical Sciences Complex, Trinidad and Tobago with a 5mm pruritic lesion on her left heel...
November 27, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27974988/surgical-management-of-giant-genital-condyloma-acuminata-by-using-double-keystone-flaps
#15
Peri Eriad Yunir, Chaidir A Mochtar, Agus Rizal A H Hamid, Chaula L Sukasah, Rainy Umbas
Condyloma acuminata in the external genitalia (genital warts) is a sexually transmitted disease that is often caused by human papillomavirus (HPV). We report a case of giant genital condyloma acuminata in a 35-year-old male patient with HIV comorbidity treated by wide surgical excision. Excision defect was covered with split thickness skin graft (STSG) and double keystone flaps. There was no complication after surgery. Ten months following surgery, there was no new condyloma lesion and the patient had normal voiding and erectile functions...
2016: Case Reports in Urology
https://www.readbyqxmd.com/read/27974929/crushing-injuries-of-the-foot-and-ankle-with-complex-open-fractures-result-of-a-prospective-study-with-a-3-year-follow-up
#16
D A Edelstein, I Florescu
The objective of this study was to determine the compared results of both the reconstruction surgery and the amputation in severe crushing of the foot, which led to open fractures. The type of study. Prospective. Background. Two major trauma hospitals (Floreasca Clinical Emergency Hospital and "Bagdasar Arseni" Clinical Emergency Hospital) from the university center in Bucharest. Patients. 21 patients, who sustained crushing of the foot with resulting Gustilo type III open fractures, were involved. The exclusion criteria were represented by open fractures that had very gross destructions of the neurovascular bundle, for which the amputation was the only solution, with no modality to reconstruct whatsoever...
July 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27936549/mechanisms-of-sodium-insertion-extraction-on-the-surface-of-defective-graphenes
#17
James C Pramudita, Aditya Rawal, Mohammad Choucair, Daniele Pontiroli, Giacomo Magnani, Mattia Gaboardi, Mauro Riccò, Neeraj Sharma
Two chemically synthesized defective graphene materials with distinctly contrasting extended structures and surface chemistry are used to prepare sodium-ion battery electrodes. The difference in electrode performance between the chemically prepared graphene materials is qualified based on correlations with intrinsic structural and chemical dissimilarities. The overall effects of the materials' physical and chemical discrepancies are quantified by measuring the electrode capacities after repeated charge/discharge cycles...
December 28, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27905181/effectiveness-of-collagen-oxidised-regenerated-cellulose-silver-containing-composite-wound-dressing-for-the-treatment-of-medium-depth-split-thickness-skin-graft-donor-site-wounds-in-multi-morbid-patients-a-prospective-non-comparative-single-centre-study
#18
Alexander Konstantinow, Tatjana V Fischer, Johannes Ring
Split-thickness skin grafting (STSG) is a widely used method in reconstructive surgery, but donor site wounds (DSWs) are often slow healing and painful. This prospective study evaluated the performance of a composite wound dressing containing collagen/oxidised regenerated cellulose in the treatment of medium-depth (0·4 mm) DSWs in 25 multi-morbid patients with chronic leg ulcers requiring STSG. The range of patients' ages was 44-84 years (mean 71·6 years) with DSW sizes ranging between 12 and 162 cm(2) (mean 78 cm(2) )...
December 1, 2016: International Wound Journal
https://www.readbyqxmd.com/read/27810611/management-of-skin-defect-following-resection-of-stage-iv-scalp-melanoma-a-case-report
#19
Yana Puckett, Eileen Bui, Sharmila Dissanaike
INTRODUCTION: Surgical defect left following excision of a large and neglected scalp melanoma of can pose a significant challenge for the surgeon. Scalp reconstruction encompasses options such as skin flaps, grafts, and various mechanical techniques. In scalp excision that involves dissection beyond the galea, skin grafts and flaps may not take well and not enough tissue may be available for a skin flap. PRESENTATION OF CASE: We present the case of a 64 year-old male with a giant scalp melanoma...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27746062/glansectomy-and-split-thickness-skin-graft-for-penile-cancer
#20
Arie S Parnham, Maarten Albersen, Varun Sahdev, Michelle Christodoulidou, Raj Nigam, Peter Malone, Alex Freeman, Asif Muneer
BACKGROUND: Penile cancer is a rare malignancy that is confined to the glans in up to four out of five cases. Although descriptions of glansectomy exist, there are no contemporary video explanations or large published single centre series. OBJECTIVE: To show the efficacy and safety of glansectomy and split-thickness skin graft (STSG) reconstruction. DESIGN, SETTING, AND PARTICIPANTS: Data were collected retrospectively for patients identified from surgical theatre diaries between February 2005 and January 2016...
October 13, 2016: European Urology
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