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Audrey Moreau, Louise Galmiche, Veronique Minard-Colin, Martin Rachwalski, Kahina Belhous, Daniel Orbach, Aline Joly, Arnaud Picard, Natacha Kadlub
OBJECTIVES: Melanotic neuroectodermal tumor of infancy (MNTI) of the head and neck is a rare entity with uncertain clinical behavior. Radical surgical resection is the current recommended treatment, however this can cause severe aesthetic and functional sequelae. The aim of this study was to clinically characterize MNTIs and to stratify risk factors that may influence locoregional recurrence. METHODS: A retrospective multicenter study, including 11 patients from eight centers with a confirmed diagnosis of MNTI, was conducted...
December 12, 2017: Journal of Cranio-maxillo-facial Surgery
Monica Stephany Kirigin, Tihana Džombeta, Sven Seiwerth, Marko Mesić, Jasminka Stepan Giljević, Božo Krušlin
OBJECTIVE: To present a case of a 6-month-old infant with melanotic neuroectodermal tumor of infancy (MNTI) in the upper arm. CLINICAL PRESENTATION AND INTERVENTION: A 6-month-old female presented with a well-circumscribed lesion of the upper arm at the Children's Hospital Zagreb. A biopsy was performed and microscopy revealed 2 cell populations consisting of small neuroblastic cells and larger melanin-containing epithelial cells. An excisional biopsy performed 1 month later confirmed the initial diagnosis of MNTI, but the tumor had increased in size since the initial biopsy...
2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Audrey Moreau, Louise Galmiche, Kahina Belhous, Gerald Franchi, Vincent Couloigner, Jerome Nevoux, Pierre Antoine Aymard, Arnaud Picard, Veronique Minard-Colin, Natacha Kadlub
We present the case of a woman referred to our department at 34 weeks of pregnancy with a fetal ultrasonographic scan showing a mass that had developed within the right maxilla with invasion of the orbit. A retrospective examination showed that this tumor had been present since the 12th week of pregnancy. At 39+4 weeks of gestation, a boy was born. He presented a black firm aspect in the maxilla. A computed tomographic scan and magnetic resonance imaging revealed a soft tissue swelling over the right maxilla, extending into the orbit but without invasion of the globe...
October 9, 2017: Journal of Pediatric Hematology/oncology
Corinthia Fabien-Dupuis, Benjamin Niver, Nick Shillingford, Larry Wang, Paul J Kokorowski, Shengmei Zhou
Testicular melanotic neuroectodermal tumor of infancy (MNTI) is extremely rare, with 2 cases reported in the literature. Its rarity and rapid and infiltrative growth pattern pose a diagnostic challenge. A previously healthy 3-month-old male, presented with a history of worsening left hemiscrotal swelling for 1 week. An outside ultrasound was suggestive of testicular torsion. Left orchiectomy demonstrated a mass occupying almost entire testicle with a variegated cut surface, with areas of pigmentation, necrosis, and hemorrhage...
September 2017: Pediatric and Developmental Pathology
Neelam Noel Andrade, Paul C Mathai, Vyankatesh Sahu, Neha Aggarwal, Tanvi Andrade
Melanotic neuroectodermal tumour of infancy (MNTI) is rare, rapidly growing, pigmented neoplasm of neural crest origin. It is generally accepted as a benign tumour despite of its rapid and locally destructive growth. It primarily affects the maxilla of infants during the first year of life. Surgical excision is considered as the treatment of choice. The recurrence rate varies between 10% and 15%, and malignant behaviour has been reported in 6.5% of cases. We report a case of MNTI, associated with an erupted primary tooth in a 5-month-old male child...
September 2016: Journal of Oral Biology and Craniofacial Research
Hongcai Gao, John B Goodenough
A symmetric sodium-ion battery with an aqueous electrolyte is demonstrated; it utilizes the NASICON-structured Na3 MnTi(PO4 )3 as both the anode and the cathode. The NASICON-structured Na3 MnTi(PO4 )3 possesses two electrochemically active transition metals with the redox couples of Ti(4+) /Ti(3+) and Mn(3+) /Mn(2+) working on the anode and cathode sides, respectively. The symmetric cell based on this bipolar electrode material exhibits a well-defined voltage plateau centered at about 1.4 V in an aqueous electrolyte with a stable cycle performance and superior rate capability...
October 4, 2016: Angewandte Chemie
Jouni Lahti, Ansku Holstila, Minna Mänty, Eero Lahelma, Ossi Rahkonen
BACKGROUND: Disability retirement is an economic, public health and work life issue causing costs for employees, workplaces and society. Adopting physical activity at middle-age has been associated with reduced risk of sickness absence and mortality. The aim of this study was to examine how changes over time in leisure time physical activity are associated with subsequent disability retirement among midlife employees. METHODS: The Helsinki Health Study cohort baseline (phase 1) mail questionnaire survey data were collected in 2000, 2001 and 2002 among 40-60-year-old employees of the City of Helsinki, Finland...
September 6, 2016: International Journal of Behavioral Nutrition and Physical Activity
Kimberly A Foster, Asim Choudhri, Ryan Lingo, Frederick Boop
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare lesion that typically manifests in the first year of life, most commonly involving the facial bones. We present 2 infants with MNTI involving the posterior skull with associated compression of the superior sagittal sinus (SSS). A review of the anatomical locations of MNTI is offered, and the implications of SSS involvement are described. This represents the first known description of MNTI with involvement of the posterior SSS.
2017: Pediatric Neurosurgery
David J Barnes, Edward Hookway, Nick Athanasou, Takeshi Kashima, Udo Oppermann, Simon Hughes, Daniel Swan, Dietrich Lueerssen, John Anson, A Bassim Hassan
BACKGROUND: Melanotic neuroectodermal tumor of infancy (MNTI) is exceptionally rare and occurs predominantly in the head and neck (92.8 % cases). The patient reported here is only the eighth case of MNTI presenting in an extremity, and the first reported in the fibula. CASE PRESENTATION: A 2-month-old female presented with a mass arising in the fibula. Exhaustive genomic, transcriptomic, epigenetic and pathological characterization was performed on the excised primary tumor and a derived cell line...
August 12, 2016: BMC Cancer
Minna Mänty, Anne Kouvonen, Tea Lallukka, Jouni Lahti, Eero Lahelma, Ossi Rahkonen
OBJECTIVES: The aim of this study was to examine the association between pre-retirement physical working conditions and changes in physical health functioning during the retirement transition process. METHODS: Follow-up survey data were collected among ageing employees of the City of Helsinki, Finland, at three time points: wave 1 (2000-2002), wave 2 (2007) and wave 3 (2012). We focused on those who retired full time due to old age between waves 1 and 3 (N=1658)...
September 1, 2016: Scandinavian Journal of Work, Environment & Health
Christopher Maroun, Ibrahim Khalifeh, Elie Alam, Pierre Abi Akl, Raya Saab, Roger V Moukarbel
Melanotic Neuroectodermal Tumor of Infancy (MNTI) is a rare, locally aggressive neoplasm with a predilection for the head and neck area, most commonly occurring in the maxilla. The vast majority of treatment modalities for all cases of MNTI to date have involved surgical intervention only, with just 9.6 % involving some sort of chemotherapy, radiotherapy, or a combination of the prior mentioned modalities. There is very limited information available regarding the use of neoadjuvant chemotherapy, due to its rare nature...
December 2016: European Archives of Oto-rhino-laryngology
Xiao Wu, Samantha Shankar, William R Munday, Ajay Malhotra
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare pigmented craniofacial tumor of newborns and infants. We report the imaging findings of a 3-month old male patient with a maxillary MNTI. Detailed discussion on imaging features on various magnetic resonance sequences and CT scan are included. Characteristic radiographic appearance is also described. MNTI, of neural crest origin, display a biphasic population of melanin containing cells and neuroblastic cells, within a moderately vascularized fibrous stroma...
September 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Yangyang Ma, Jicui Zheng, Shaobao Yang, Haitao Zhu, Kuiran Dong, Xianmin Xiao, Lian Chen
Melanotic neuroectodermal tumor of infancy is rare. Only 3 cases have been reported in the soft tissue of the extremities up to date. It has a typically biphasic feature in morphology. Epithelial and melanotic markers are positive in the epitheliod cells and neuron-specific enolase or synaptophysin is positive in the small blue round cells in immunohistochemistry. Radical resection and close follow-up is the treatment strategy in general situation. Here we report one case of MNTI in the upper extremity with review of the literature...
2015: International Journal of Clinical and Experimental Pathology
Murat Kocaoğlu, Selçuk Göçmen, Özkan Çeliker, Duygu Çeliker, Abdullah Topçu, Erdal Çoşkun
Melanotic neuroectodermal tumor of infancy (MNTI) is a rarely occurring neoplasm of neural crest origin, appearing in children during the first year of life. MNTI is a benign tumor but is nonetheless locally aggressive; it usually originates from the maxilla and the mandible. Recognition of the diagnostic features of MNTI is important, so that it may be differentiated from benign lesions (dermoid or epidermoid cysts, vascular lesions) as well as from malignant lesions such as small round cell tumors. We present a case of a 2-month-old infant who developed right retroauricular swelling with extension through the calvarium and into the central nervous system...
March 2015: Turkish Journal of Pediatrics
Luciana Strieder, Román Carlos, Jorge Esquiche León, Alfredo Ribeiro-Silva, Victor Costa, Estela Kaminagakura
OBJECTIVE: The aim of this study is to report 2 cases of melanotic neuroectodermal tumor of infancy (MNTI), emphasizing the analysis of intratumoral immune cells by immunohistochemistry. STUDY DESIGN: Case 1: A 6-month-old girl presented with a 3-cm tumor in the anterior region of the left maxilla. Case 2: A 4-month-old boy presented with a 4-cm tumor in the anterior region of the left maxilla. Microscopically, case 1 had predominantly neuroblast-like cells supported by fibrillary neuropil-like stroma arranged in an alveolar pattern, whereas case 2 exhibited scattered melanocyte-like and neuroblast-like cells supported by fibrovascular stroma...
February 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Corinthia Fabien-Dupuis, Benjamin Niver, Nick Shillingford, Larry Wang, Paul J Kokorowski, Shengmei Zhou
Testicular melanotic neuroectodermal tumor of infancy (MNTI) is extremely rare, with 2 cases reported in the literature. Its rarity, rapid and infiltrative growth pattern pose a diagnostic challenge. A previously healthy 3-month old male, presented with a history of worsening left hemiscrotal swelling for one week. An outside ultrasound was suggestive of testicular torsion. Left orchiectomy demonstrated a mass occupying almost entire testicle with a variegated cut surface, with areas of pigmentation, necrosis and hemorrhage...
December 15, 2015: Pediatric and Developmental Pathology
Kenjiro Higashi, Takenori Ogawa, Masaei Onuma, Hajime Usubuchi, Yoshimichi Imai, Iori Takata, Hiroshi Hidaka, Mika Watanabe, Yoji Sasahara, Shigeto Koyama, Shigeo Kure, Yukio Katori
Melanotic neuroectodermal tumor of infancy (MNTI) is an extremely rare, pigmented neoplastic entity of neural crest origin. Histological and immunohistochemical profiles indicate the presence of two components, small rounded neuroblast-like cellular areas and areas with large melanin-containing cells which consist of combination of neural, melanocytic, and epithelial cell types. Here we present two interesting cases of infants with MNTI which have different clinicopathological features. The first case is a 3-month-old female with rapidly growing MNTI involving the lacrimal sac and inferior wall of the orbital cavity, treated with total maxillectomy without orbital exenteration followed by chemotherapy...
August 2016: Auris, Nasus, Larynx
Assis Filipe Medeiros Albuquerque, José Ferreira Cunha, Rafael Linard Avelar, Eduardo Juca, Fabio Wildson Gurgel Costa, Mario Sérgio Macedo
The melanotic neuroectodermal tumor of infancy (MNTI) is a rare childhood neoplasm with an alarming but classical clinical presentation. We present the case of a 2-month-old male infant treated with surgery for an aggressive MNTI on the alveolar process of the maxilla. Radiographic examination showed a diffuse osteolytic radiolucent lesion in the right maxilla, and displacement and dysmorphic changes in the developing primary tooth buds. The patient remained well without evidence of recurrence for 6 months after surgery...
September 2016: Head and Neck Pathology
Asaranti Kar, Priyadarshini Biswal, Susmita Behera, Ipsita Dhal, Surabhi
Melanotic neuroectodermal tumour of infancy (MNTI) is a rare, benign but locally aggressive neoplasm of infants commonly affecting the maxilla. It can also involve other areas like skull, mandible, brain and epididymis. The tumour comprise of dual populations of cells like small, basophilic neuroblast like cells and large pigment laden epithelial cells arranged in tubular and pseudoglandular pattern. The proportion of two components varies and therefore the diagnosis can be difficult in absence of the large cells...
September 2015: Journal of Clinical and Diagnostic Research: JCDR
Natalia Miękus, Piotr Kowalski, Ilona Olędzka, Alina Plenis, Ewa Bień, Aleksandra Miękus, Małgorzata Krawczyk, Elżbieta Adamkiewicz-Drożyńska, Tomasz Bączek
The main aim of the presented study was to develop a reliable and non-time-consuming method for the simultaneous separation of biogenic amines (BAs) like noradrenalin, adrenalin, dopamine and their main metabolites - homovanillic acid (HVA), vanillylmandelic acid (VMA), 3,4-dihydroxyphenylacetic acid (DOPAC) - in urine samples. To achieve this, the validated α-cyclodextrin (α-CD)-modified micellar electrokinetic chromatography method with DAD was proposed. The optimized separation parameters were as follows: background electrolyte was composed of 10mM sodium tetraborate decahydrate, 30mM SDS, 15% (v/v) methanol and 25mM α-CD, adjusted to pH 9...
October 15, 2015: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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