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Tooth transplant

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https://www.readbyqxmd.com/read/29765167/the-mineral-content-of-the-hard-dental-tissue-of-mesiodens
#1
Sanja Tanaskovic-Stankovic, Irena Tanaskovic, Nemanja Jovicic, Marina Miletic-Kovacevic, Tatjana Kanjevac, Zoran Milosavljevic
OBJECTIVE: Mesiodens is the most common form of supernumerary tooth mainly located between the maxillary central incisors. Its etiology is not completely understood but both genetic and environmental factors are assumed. The degree of mineralization and inorganic element content in hard tooth tissues is poorly understood as well as is the durability and suitability for allo- and auto-transplantation. Therefore aim of this study was to examine the content of inorganic elements. MATERIALS AND METHODS: This study included 26 mesiodens teeth and 26 normal central incisor teeth as controls...
May 15, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29763345/tissue-engineering-of-necrotic-dental-pulp-of-immature-teeth-with-apical-periodontitis-in-dogs-radiographic-and-histological-evaluation
#2
Eman A El Ashiry, Najlaa M Alamoudi, Mahmoud K El Ashiry, Hagar A Bastawy, Douaa A El Derwi, Hazem M Atta
AIM: To evaluate tissue engineering technology to regenerate pulp-dentin like tissues in pulp canals of immature necrotic permanent teeth with apical periodontitis in dogs. STUDY DESIGN: The study was performed on 36 teeth in 12 dogs. The experiment was carried out using split mouth design. In each dog 3 teeth were selected for implementing the study procedure. Apical periodontitis was induced in Group A and B teeth. Group (A): immature upper left 2nd permanent incisors that were transplanted with a construct of autologous dental pulp stem cells with growth factors seeded in a chitosn hydrogel scaffold...
May 15, 2018: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29703239/allogeneic-transplantation-of-mobilized-dental-pulp-stem-cells-with-the-mismatched-dog-leukocyte-antigen-type-is-safe-and-efficacious-for-total-pulp-regeneration
#3
Koichiro Iohara, Shinji Utsunomiya, Sakae Kohara, Misako Nakashima
BACKGROUND: We recently demonstrated that autologous transplantation of mobilized dental pulp stem cells (MDPSCs) was a safe and efficacious potential therapy for total pulp regeneration in a clinical study. The autologous MDPSCs, however, have some limitations to overcome, such as limited availability of discarded teeth from older patients. In the present study, we investigated whether MDPSCs can be used for allogeneic applications to expand their therapeutic use. METHODS: Analysis of dog leukocyte antigen (DLA) was performed using polymerase chain reaction from blood...
April 27, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29702010/pulp-regeneration-by-3-dimensional-dental-pulp-stem-cell-constructs
#4
Y Itoh, J I Sasaki, M Hashimoto, C Katata, M Hayashi, S Imazato
Dental pulp regeneration therapy for the pulpless tooth has attracted recent attention, and clinical trial studies are underway with the tissue engineering approach. However, there remain many concerns, including the extended period for regenerating the dental pulp. In addition, the use of scaffolds increases the risk of inflammation and infection. To establish a basic technology for novel dental pulp regenerative therapy that allows transplant of pulp-like tissue, we attempted to fabricate scaffold-free 3-dimensional (3D) cell constructs composed of dental pulp stem cells (DPSCs)...
April 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29684912/cementum-regeneration-using-stem-cells-in-the-dog-model-a-systematic-review
#5
REVIEW
Jacqueline Crossman, Maryam Elyasi, Tarek El-Bialy, Carlos Flores Mir
OBJECTIVE: Restoring lost tissues of the periodontium, such as cementum, is essential in reducing the risk of tooth loss due to periodontitis and/or severe root resorption. Stem cell therapy is a regenerative strategy in cementum regeneration. This systematic review aimed to analyze the effect of various stem cells and their transplantation method on cementum regeneration in the dog model. METHODS: Electronic databases were searched, in addition to performing hand searches and a gray literature search...
April 3, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29615915/application-of-mesenchymal-stem-cells-for-therapeutic-agent-delivery-in-anti-tumor-treatment
#6
REVIEW
Daria S Chulpanova, Kristina V Kitaeva, Leysan G Tazetdinova, Victoria James, Albert A Rizvanov, Valeriya V Solovyeva
Mesenchymal stem cells (MSCs) are non-hematopoietic progenitor cells, which can be isolated from different types of tissues including bone marrow, adipose tissue, tooth pulp, and placenta/umbilical cord blood. There isolation from adult tissues circumvents the ethical concerns of working with embryonic or fetal stem cells, whilst still providing cells capable of differentiating into various cell lineages, such as adipocytes, osteocytes and chondrocytes. An important feature of MSCs is the low immunogenicity due to the lack of co-stimulatory molecules expression, meaning there is no need for immunosuppression during allogenic transplantation...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29606400/cell-homing-for-pulp-tissue-engineering-with-endogenous-dentin-matrix-proteins
#7
Matthias Widbiller, Ronald B Driesen, Andreas Eidt, Ivo Lambrichts, Karl-Anton Hiller, Wolfgang Buchalla, Gottfried Schmalz, Kerstin M Galler
INTRODUCTION: Compelling evidence pinpoints that pulp tissue engineering after the transplantation of stem cells is possible. Although intriguing, severe problems regarding clinical feasibility remain. Cell homing has been proposed as a viable alternative in which dentin-derived growth factors in a conducive scaffold may attract resident cells to form pulplike tissue. In this study, an ectopic animal model for in situ dental pulp tissue engineering was developed to evaluate whether pulplike tissue formation in empty root canals after the attraction of stem cells was possible and whether this could be enhanced by dentin-derived growth factors...
March 29, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29538193/transplantation-of-autogenous-bone-block-with-an-osseointegrated-implant-seedling-technique-with-twelve-month-follow-up
#8
Huseyin Burak Kutlu, Samir Goyushov, Bünyamin Calisan, Tolga F Tözüm
OBJECTIVE: Loss of teeth frequently results in compound horizontal and vertical alveolar bone defects. An appropriate bone structure is the key for implant placement and bony support of soft tissues. Advanced bone augmentation techniques are required for the reconstruction of these defects. This report will present a new bone block grafting technique with 12-month follow-up. METHOD: The seedling technique was used to augment the alveolar bone 3-dimensionally with autologous bone block and an osseointegrated implant in a 2-stage procedure...
March 13, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29525925/outcomes-of-autotransplanted-teeth-and-prognostic-factors-a-10-year-retrospective-study
#9
Sujin Yang, Bock-Young Jung, Nan-Sim Pang
OBJECTIVES: This retrospective study aimed to investigate the clinical outcome of tooth autotransplantation and related prognostic factors. MATERIALS AND METHODS: Eighty-two cases of transplanted teeth from March 2006 to December 2016 were retrospectively investigated by medical records and radiographs. The clinical outcomes of transplanted teeth, which included tooth survival, inflammatory root resorption (IRR), ankylosis, and marginal bone loss (MBL), and the related prognostic factors were assessed via survival analysis...
March 10, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29511942/the-evaluation-of-the-transport-medium-for-extracted-premolars-prior-to-cryopreservation-a-systematic-literature-review
#10
REVIEW
Noëmi M C De Roo, Laurent A M Thierens, Liesbeth Temmerman, Guy A M De Pauw
Prior to cryopreservation, a tooth is transported from a contaminated oral environment to the tooth bank. Our objective was to identify all studies reporting or investigating a transport protocol prior to the cryopreservation of teeth, in terms of decontamination of the subjects. The systematic literature search (1970-2017) was based on MEDLINE via PubMed, Web of Science and the Cochrane Library. The reference lists of the included studies and the Science Citation Index were used for hand searching (snowballing)...
March 7, 2018: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29495925/in-vivo-periodontium-formation-around-titanium-implants-using-periodontal-ligament-cell-sheet
#11
Kaoru Washio, Yusuke Tsutsumi, Yuka Tsumanuma, Kosei Yano, Supreda Suphanantachat Srithanyarat, Ryo Takagi, Shizuko Ichinose, Walter Meinzer, Masayuki Yamato, Teruo Okano, Takao Hanawa, Isao Ishikawa
Osseointegrated implants have been recognized as being very reliable and having long-term predictability. However, host defense mechanisms against infection have been known to be impaired around a dental implant because of the lack of a periodontal ligament (PDL). The purpose of our experimental design was to produce cementum and PDL on the implant surface adopting cell sheet technology. To this aim we used PDL-derived cells, which contain multipotential stem cells, as the cell source and we cultured them on an implant material constituted of commercially pure titanium treated with acid etching, blasting, and a calcium phosphate (CaP) coating to improve cell attachment...
April 10, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29489425/bone-morphogenetic-protein-2-coordinates-early-tooth-mineralization
#12
Z Malik, M Alexiou, B Hallgrimsson, A N Economides, H U Luder, D Graf
Formation of highly organized dental hard tissues is a complex process involving sequential and ordered deposition of an extracellular scaffold, followed by its mineralization. Odontoblast and ameloblast differentiation involves reciprocal and sequential epithelial-mesenchymal interactions. Similar to early tooth development, various Bmps are expressed during this process, although their functions have not been explored in detail. Here, we investigated the role of odontoblast-derived Bmp2 for tooth mineralization using Bmp2 conditional knockout mice...
February 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29450945/clinical-application-of-3d-technology-for-tooth-autotransplantation-a-case-report
#13
Keunhee Kim, Hee-Seung Choi, Nan-Sim Pang
This report presents two cases of tooth autotransplantation using cone-beam computed tomography (CBCT), the three-dimensional (3D) simulation dental planning software and a computer-aided rapid prototyping (CARP) model. Two hopeless teeth of adult patients were replaced as their third molar teeth. Before deciding the autotransplantation, diagnostic CBCT images were acquired and imported to SimPlant software. The SimPlant dental program was used for surgical simulation prior to autotransplantation, which created 3D images of the available donor teeth and recipient site tooth and superimposed the images to display their morphological similarity...
February 16, 2018: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://www.readbyqxmd.com/read/29446213/osteopontin-is-essential-for-il-1%C3%AE-production-and-apoptosis-in-peri-implantitis
#14
Chengye Che, Jie Liu, Jianjun Yang, Lei Ma, Na Bai, Qian Zhang
BACKGROUND AND PURPOSE: Peri-implantitis is caused by a cascade of host and microbial factors leading to an oral inflammatory disease. The inflammation proliferates into supporting tissues surrounding implants and may finally lead to a complete loss of osseointegration. Being a phosphorylated glycoprotein secreted by immunocompetent cells, osteopontin (OPN) is involved in the differentiation of odontoblast-like cells during pulpal healing following tooth transplantation and the secretion of type I collagen in reparative dentin...
February 15, 2018: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/29398865/tooth-for-a-tooth-tissue-engineering-made-easy-at-dental-chairside
#15
Vandana Kharidhi Laxman, Rajendra Gururao Desai
Background: Stem cells are unspecialized, multipotent cells which can differentiate into different cell types. The human periodontal ligament encloses subpopulation of Periodontal Ligament Stem Cells (PDLSCs) which are able to regenerate the periodontium by differentiating into various cells of PDL. Literature have shown the promising results of periodontal regeneration by exvivo cultured transplantation of PDLSCs into the osseous defects. Methods: Based on current literature on use of ex vivo culture and associated problems, a novel technique is being presented , Stem cell application in periodontal regeneration (SAI-PRT) which uses autologous PDLSCs along with its niche adhering to extracted tooth root for direct application using gelatin sponge as scaffold in regeneration of intrabony periodontal defect bypassing ex-vivo culture...
March 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29383000/evaluation-of-a-new-surgical-technique-for-closing-oroantral-fistula-using-auto-transplanted-upper-third-molar-a-1-year-follow-up-study
#16
Mounzer Assad, Maysaa Alkhaled, Mohammed N Alhajj
Background: Oroantral fistula (OAF) is considered a frequent complication in dental practice. Many surgical techniques/methods have been proposed to close it. The aim of this study was to evaluate the auto-transplantation of upper third molar for closing OAF. Materials and Methods: Twenty patients participated in this study aged between 20 and 40 years old. The OAF was closed by auto-transplantation of upper third molar placed directly in the socket of the extracted tooth...
March 2018: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/29333321/periodontal-wound-healing-following-reciprocal-autologous-root-transplantation-in-class-iii-furcation-defects
#17
Naoshi Takeuchi, Yoshinori Shirakata, Yukiya Shinohara, Kotaro Sena, Kazuyuki Noguchi
Purpose: Furcation involvement in the molars is difficult to treat, and has been recognized as a risk factor for tooth loss. Although periodontal regenerative therapies, including guided tissue regeneration and various types of bone grafts, have been applied to furcation defects, the effects of these treatments are limited, especially in large class III furcation defects. The purpose of this pilot study was to investigate the effect of reciprocal autologous root transplantation on periodontal wound healing and regeneration in class III furcation defects in dogs...
December 2017: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/29316063/bilirubin-reversibly-affects-cell-death-and-odontogenic-capacity-in-shed
#18
Haruyoshi Yamaza, Erika Tomoda, Soichiro Sonoda, Kazuaki Nonaka, Toshio Kukita, Takayoshi Yamaza
OBJECTIVE: Hyperbilirubinemia in patients with biliary atresia causes deciduous tooth injuries such as green pigmentation and dentin hypoplasia. In patients with biliary atresia who received liver transplantation, tooth structure appears to be recovered radiographically. Nevertheless, little is known about cellular mechanisms underlying bilirubin-induced damage and suppression of deciduous tooth formation. In this study, we examined the effects of bilirubin in stem cells from human exfoliated deciduous teeth (SHED) in vitro...
January 9, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29314214/oral-and-craniofacial-manifestations-in-a-hunter-syndrome-patient-with-hematopoietic-stem-cell-transplantation-a-case-report
#19
Rafaela de Oliveira Torres, Andréa Vaz Braga Pintor, Fábio Ribeiro Guedes, Liana Bastos Freitas-Fernandes, Anneliese Lopes Barth, Dafne Dain Gandelman Horovitz, Ivete Pomarico Ribeiro de Souza
We described herein the oral and craniofacial features of a 7-year-old boy, diagnosed in utero with mucopolysaccharidosis II (MPS II), who was treated with hematopoietic stem cell transplantation (HSCT) at 70 days of age. The main oral clinical findings were the following: macroglossia, posterior cross-bite, crowding, pointed cuspid teeth, delayed tooth eruption, retained primary teeth, and enamel hypoplasia. The image examination showed: retention eruption, posterior primary teeth with short roots, absence of some permanent teeth, and stretching of the stylohyoid processes bilaterally...
January 2018: Special Care in Dentistry
https://www.readbyqxmd.com/read/29298406/a-miniature-swine-model-for-stem-cell-based-de-novo-regeneration-of-dental-pulp-and-dentin-like-tissue
#20
Xiaofei Zhu, Jie Liu, Zongdong Yu, Chao-An Chen, Hacer Aksel, Adham A Azim, George T-J Huang
The goal of this study was to establish mini-swine as a large animal model for stem cell-based pulp regeneration studies. Swine dental pulp stem cells (sDPSCs) were isolated from mini-swine and characterized in vitro. For in vivo studies, we first employed both ectopic and semi-orthotopic study models using severe combined immunodeficiency mice. One is hydroxyapatite-tricalcium phosphate (HA/TCP) model for pulp-dentin complex formation, and the other is tooth fragment model for complete pulp regeneration with new dentin depositing along the canal walls...
February 2018: Tissue Engineering. Part C, Methods
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