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https://www.readbyqxmd.com/read/29316063/bilirubin-reversibly-affects-cell-death-and-odontogenic-capacity-in-shed
#1
Haruyoshi Yamaza, Erika Tomoda, Soichiro Sonoda, Kazuaki Nonaka, Toshio Kukita, Takayoshi Yamaza
OBJECTIVE: Hyperbilirubinemia in patients with biliary atresia causes deciduous tooth injuries such as green pigmentation and dentin hypoplasia. In patients with biliary atresia who received liver transplantation, tooth structure appears to be recovered radiographically. Nevertheless, little is known about cellular mechanisms underlying bilirubin-induced damage and suppression of deciduous tooth formation. In this study, we examined the effects of bilirubin in stem cells from human exfoliated deciduous teeth (SHED) in vitro...
January 9, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29314214/oral-and-craniofacial-manifestations-in-a-hunter-syndrome-patient-with-hematopoietic-stem-cell-transplantation-a-case-report
#2
Rafaela de Oliveira Torres, Andréa Vaz Braga Pintor, Fábio Ribeiro Guedes, Liana Bastos Freitas-Fernandes, Anneliese Lopes Barth, Dafne Dain Gandelman Horovitz, Ivete Pomarico Ribeiro de Souza
We described herein the oral and craniofacial features of a 7-year-old boy, diagnosed in utero with mucopolysaccharidosis II (MPS II), who was treated with hematopoietic stem cell transplantation (HSCT) at 70 days of age. The main oral clinical findings were the following: macroglossia, posterior cross-bite, crowding, pointed cuspid teeth, delayed tooth eruption, retained primary teeth, and enamel hypoplasia. The image examination showed: retention eruption, posterior primary teeth with short roots, absence of some permanent teeth, and stretching of the stylohyoid processes bilaterally...
January 4, 2018: Special Care in Dentistry
https://www.readbyqxmd.com/read/29298406/a-miniature-swine-model-for-stem-cell-based-de-novo-regeneration-of-dental-pulp-and-dentin-like-tissue
#3
Xiaofei Zhu, Jie Liu, Zongdong Yu, Chao-An Chen, Hacer Aksel, Adham A Azim, George T-J Huang
The goal of this study was to establish mini-swine as a large animal model for stem cell-based pulp regeneration studies. Swine dental pulp stem cells (sDPSCs) were isolated from mini-swine and characterized in vitro. For in vivo studies, we first employed both ectopic and semi-orthotopic study models using severe combined immunodeficiency mice. One is hydroxyapatite-tricalcium phosphate (HA/TCP) model for pulp-dentin complex formation, and the other is tooth fragment model for complete pulp regeneration with new dentin depositing along the canal walls...
January 3, 2018: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/29284459/autotransplantation-of-mature-and-immature-third-molars-in-23-chinese-patients-a-clinical-and-radiological-follow-up-study
#4
Haozhe Tang, Zhengyan Shen, Minhong Hou, Ligeng Wu
BACKGROUND: We investigated the clinical and radiographic outcomes of autotransplanted teeth over a follow-up period of 2 to 8 years, and summarize the findings of other relevant studies with regard to the primary factors that influence a good prognosis in such patients. METHODS: Twenty-three patients (6 men, 17 women) who attended Tanggu Stomatological Hospital, Tianjin, China, from 2008 through 2013, were included in the study. These patients presented with a variety of dental problems, including tooth loss, residual crowns, missing first or second molars, dental trauma, tooth fracture, and unrestored teeth...
December 28, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/29276776/periodontitis-in-ch%C3%A3-diak-higashi-syndrome-an-altered-immunoinflammatory-response
#5
V Thumbigere Math, P Rebouças, P A Giovani, R M Puppin-Rontani, R Casarin, L Martins, L Wang, K Krzewski, W J Introne, M J Somerman, F H Nociti, K R Kantovitz
Chédiak-Higashi syndrome (CHS), a rare autosomal recessive disorder caused by mutations in the lysosomal trafficking regulator gene (LYST), is associated with aggressive periodontitis. It is suggested that LYST mutations affect the toll-like receptor (TLR)-mediated immunoinflammatory response, leading to frequent infections. This study sought to determine the periodontal status of patients with classic (severe) and atypical (milder) forms of CHS and the immunoregulatory functions of gingival fibroblasts in CHS patients...
January 2018: JDR Clinical and Translational Research
https://www.readbyqxmd.com/read/29166493/dystrophic-calcification-of-maxillary-sinus-in-pediatric-patients-with-liver-transplantation-and-pigmentation-of-dental-organ
#6
Adriana Furtado de Macedo, Claudio Costa, Regina Helena Guedes da Motta Mattar, Ramiro Anthero de Azevedo
OBJECTIVE: To report a case of severe dystrophic calcification in maxillary sinus of a child with liver transplantation and dental organs pigmented by hyperbilirubinemia. CASE DESCRIPTION: female patient, 12 years old, with liver transplantation performed at the age of 7 due to extrahepatic biliary atresia (EHBA). The patient was receiving the immunosuppressant tacrolimus (2 mg daily). Intraoral clinical exam showed tooth green pigmentation by bilirubin. Cone-beam volumetric computed tomography (CT) was performed to verify radiographic density of pigmented dental elements...
November 17, 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/29079051/minced-pulp-as-source-of-pulpal-mesenchymal-stem-cells-with-odontogenic-differentiation-capacity
#7
Zhnagrui Liang, Satoshi Kawano, Wei Chen, Moein S Sadrkhani, Chaehwan Lee, Euiseong Kim, Alireza Moshaverinia, Reuben H Kim, Mo Kang
INTRODUCTION: Pulp tissue regeneration is becoming a reality after discovery of mesenchymal stem cells (MSCs) residing in the pulp tissues through various clinical innovations, although MSC transplantation into the pulp space has met with challenges of in vitro cell expansion and cultures. As a way to circumvent the regulatory and technical complexities of in vitro MSC culture, we investigated the use of minced pulp tissues as a source of pulpal MSCs for tissue regeneration. METHODS: We characterized the phenotype of cells explanted from minced pulp (MP), namely MP-derived MSCs (MP-MSCs), compared with dental pulp stem cells (DPSCs) established from pulp tissues by enzyme digestion...
October 24, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29064632/the-effects-of-platelet-derived-growth-factor-bb-on-human-dental-pulp-stem-cells-mediated-dentin-pulp-complex-regeneration
#8
Maolin Zhang, Fei Jiang, Xiaochen Zhang, Shaoyi Wang, Yuqin Jin, Wenjie Zhang, Xinquan Jiang
Dentin-pulp complex regeneration is a promising alternative treatment for the irreversible pulpitis caused by tooth trauma or dental caries. This process mainly relies on the recruitment of endogenous or the transplanted dental pulp stem cells (DPSCs) to guide dentin-pulp tissue formation. Platelet-derived growth factor (PDGF), a well-known potent mitogenic, angiogenic, and chemoattractive agent, has been widely used in tissue regeneration. However, the mechanisms underlying the therapeutic effects of PDGF on dentin-pulp complex regeneration are still unclear...
October 24, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29020731/clinical-risk-factors-influencing-dental-developmental-disturbances-in-childhood-cancer-survivors
#9
Chung-Min Kang, Seung Min Hahn, Hyo Sun Kim, Chuhl Joo Lyu, Jae-Ho Lee, Jinae Lee, Jung Woo Han
Purpose: Although studies regarding dental developmental disturbances after childhood cancer treatment have increased, they have many limitations. Studies analyzing the significance of independent clinical risk factors with regard to the dental health status are also rare. We aimed to investigate the risk factors for dental developmental disturbances, particularly severe disturbances, in childhood cancer survivors (CCS). Materials and Methods: Oral examinations and retrospective reviews of medical and panoramic radiographs were performed for 196 CCS (mean age, 15...
October 10, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28975429/innovative-intraoral-cooling-device-better-tolerated-and-equally-effective-as-ice-cooling
#10
Java Walladbegi, Martin Gellerstedt, Anncarin Svanberg, Mats Jontell
PURPOSE: Most of the patients who receive myeloablative therapy prior to stem cell transplantation develop oral mucositis (OM). This adverse reaction manifests as oral mucosal erythema and ulcerations and may require high doses of morphine for pain alleviation. OM may also interfere with food intake and result in weight loss, a need for parenteral nutrition, and impaired quality of life. To date, there have been very few studies of evidence-based interventions for the prevention of OM...
November 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28962902/the-role-of-vasculature-engineering-in-dental-pulp-regeneration
#11
Waruna Lakmal Dissanayaka, Chengfei Zhang
Creating an optimal microenvironment that supports angiogenesis, cell-cell cross talk, cell migration, and differentiation is crucial for pulp/dentin regeneration. It was shown that dental stem cells being seeded onto a scaffold and transplanted in vivo could give rise to a new tissue similar to that of the native pulp. However, the unique structure of the tooth with a pulp space encased within hard dentin allows only a single blood supply from a small apical opening located at the apex of the root canals...
September 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28932154/malpositioned-canine-treatment-with-autotransplantation-and-laser
#12
Serap Keskin Tunc, Mehmet Savas Kayasan, Esma Ozeroglu, Cennet Neslihan Eroglu
Children and young adults often have tooth loss due to congenital tooth deficiency, trauma, or caries. Autotransplantation has many benefits. The transplanted tooth can be moved orthodontically, maintains alveolar bone growth potential during eruption, and functional periodontal ligament function also permits tooth eruption, allows the defected areas to be filled with the bones; gingival contour is much more successful than the one obtained with prosthesis. In this paper, treatment steps and follow-up results of autotransplantation case supported with biostimulation are mentioned...
July 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28904312/adhesion-of-human-periodontal-ligament-cells-by-three-dimensional-culture-to-the-sterilized-root-surface-of-extracted-human-teeth
#13
Chieko Mino, Toshio Iwata, Toshitsugu Kawata
Residual periodontal ligament (PDL) and cement mass on the roots of extracted teeth are factors that considerably affect tooth transplantation. Therefore, when normal extracted teeth are used for autologous transplantation, it is necessary to regenerate the PDL of the root surface. Here we describe a method to examine human PDL cell adhesion on sterilized root surfaces. Sample teeth were extracted during orthodontic treatment. PDL cells were obtained from healthy periodontal tissue explants from teeth extracted for orthodontic reasons...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28902422/transplantation-of-noncultured-stromal-vascular-fraction-cells-of-adipose-tissue-ameliorates-osteonecrosis-of-the-jaw-like-lesions-in-mice
#14
Shinichiro Kuroshima, Muneteru Sasaki, Kazunori Nakajima, Saki Tamaki, Hiroki Hayano, Takashi Sawase
The precise pathoetiology and effective treatment strategies for bisphosphonate-related osteonecrosis of the jaw (BRONJ) remain unknown. Transplantation of noncultured stromal vascular fraction (SVF) cells has been shown to be a useful method for regenerative medicine in place of stem cell therapy. This study investigated the effects of noncultured SVF transplantation on tooth extraction socket healing in mice. Both chemotherapeutic/bisphosphonate combination therapy for 7 weeks and tooth extraction of maxillary first molars at 3 weeks after drug administration were performed using female C57BL/6J mice...
September 13, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28885113/a-3d-printed-surgical-analogue-to-reduce-donor-tooth-trauma-during-autotransplantation
#15
Richard R J Cousley, Andrew Gibbons, Jeremy Nayler
Surgical trauma and prolonged extra-alveolar exposure of the donor tooth's root sheath are both complicating factors during tooth autotransplantation surgery. This case report describes a 12-year-old female patient who underwent surgical transplantation of a maxillary second premolar to a central incisor site. A three-dimensional printed analogue of the donor tooth was fabricated from a cone beam (CBCT) scan of the tooth in order to minimise the extra-oral (exposure) time and frequency of trial insertions of the donor tooth into the recipient socket...
September 8, 2017: Journal of Orthodontics
https://www.readbyqxmd.com/read/28802762/clinical-application-of-autogenous-partially-demineralized-dentin-matrix-prepared-immediately-after-extraction-for-alveolar-bone-regeneration-in-implant-dentistry-a-pilot-study
#16
T Minamizato, T Koga, Takashi I, Y Nakatani, M Umebayashi, Y Sumita, T Ikeda, I Asahina
The aim of this study was to examine the efficacy and safety of autogenous partially demineralized dentin matrix (APDDM) prepared onsite, for clinical application in bone regeneration procedures related to implant dentistry, including socket preservation, alveolar ridge augmentation, and maxillary sinus floor augmentation. In this study, 16 patients underwent dental implant placement using APDDM transplantation. There were no systemic or local complications (including surgical site infection) in any of the cases, and oral rehabilitation using dental implants was successful in all cases for at least 2 years after attachment of the suprastructure...
August 9, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28796340/application-of-differentiated-human-tonsil-derived-stem-cells-to-trembler-j-mice
#17
Saeyoung Park, Yoonyoung Choi, Geon Kwak, Young Bin Hong, Namhee Jung, Jieun Kim, Byung-Ok Choi, Sung-Chul Jung
INTRODUCTION: Mesenchymal stem cells (MSCs) can differentiate into various cell types. METHODS: In this study we investigated the potential of human tonsil-derived MSCs (T-MSCs) for neuromuscular regeneration in trembler-J (Tr-J) mice, a model for Charcot-Marie-Tooth disease type 1A (CMT1A). RESULTS: T-MSCs differentiated toward skeletal myocytes with increased expression of skeletal muscle-related markers (including troponin I type 1, and myogenin), and the formation of myotubes in vitro...
August 10, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28781844/third-molar-transplantation-combined-with-an-osteotome-sinus-lift-two-case-reports
#18
Katsuki Yamamoto, Yoshinaga Osamu, Kae Kakura, Kazuko Yamamoto, Hirofumi Kido
We report here on our application of the socket lift technique to create a transplant socket for the transplanted maxillary molar. These outcomes suggest that this technique is likely to be effective for tooth transplantation when the maxillary sinus bottom is close to the alveolar crest.
August 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28751076/periodontal-tactile-sensation-and-occlusal-loading-condition-of-autotransplanted-teeth-a-retrospective-pilot-study
#19
Tasuku Suzuki, Toru Ogawa, Jianlan Long, Juan Ramón Vanegas Sáenz, Makiko Miyashita, Michikazu Matsuda, Keiichi Sasaki
PURPOSE: The objectives of this retrospective pilot study were: (1) to examine the occlusal properties (periodontal tactile sensation, occlusal force support ability, dynamic tooth mobility, occlusal force, contact area, preferred chewing side and main occluding area) of autotransplanted teeth with no clinical complications after transplantation (postoperative periods from 1 to 7 years). METHODS: Three groups were formed from 20 subjects (23 teeth in each group): autotransplanted teeth (ATP group), teeth contralateral to the recipient site (control group A), and teeth contralateral to the donor site (control group B)...
July 24, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/28624454/ameloblast-like-characteristics-of-human-hertwig-s-epithelial-rest-of-malassez-epithelial-rest-of-malassez-cells-via-interaction-with-stem-cells-from-human-exfoliated-deciduous-teeth
#20
Hyun Nam, Gee-Hye Kim, Jae-Won Kim, Jae Cheoun Lee, Kyunghoon Lee, Sun-Ho Lee
Tooth develops through reciprocal interactions between oral epithelium and oral mesenchyme. To regenerate tooth, both components are necessary to mimic epithelial-mesenchymal interactions. In adult teeth, Hertwig's epithelial root sheath/Epithelial rests of Malassez (HERS/ERM) cells are unique epithelial cells which are derived from oral epithelium. In this study, we investigated whether HERS/ERM cells could have ameloblast-like characteristics via interaction with stem cells from human exfoliated deciduous teeth (SHEDs) as an oral mesenchymal component...
June 14, 2017: Biochemical and Biophysical Research Communications
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