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Tooth transplant

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https://www.readbyqxmd.com/read/28185382/autogenous-bone-block-grafting-provides-facial-implant-tissue-stability-long-term
#1
Fernando Verdugo, Agurne Uribarri, Antonio D'Addona
BACKGROUND: Mucosal recession (MR) and bone loss can compromise anterior implant esthetics. PURPOSE: To evaluate tissue stability and clinical outcomes of anterior implants augmented with autogenous block transplants long-term. MATERIALS AND METHODS: This prospective cross-sectional clinical study analyzed facial tissue recession of anterior implants augmented with autogenous bone blocks and compared them to adjacent teeth in forty patients 52 months post-augmentation...
February 10, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28179939/autogenous-transplantation-for-replacing-a-hopeless-tooth
#2
Mehrsa Zakershahrak, Amirabbas Moshari, Mehdi Vatanpour, Zohreh Khalilak, Afsoon Jalali Ara
Autogenous tooth transplantation (ATT) is a simple and reasonable choice for replacing the missing teeth when a proper donor tooth is available. This report presents a case of successful ATT of a maxillary right third molar for replacement of mandibular right second molar with a concomitant endodontic-periodontal disease. The mandibular second molar was believed to be hopeless due to a severe damage to coronal tooth structure, inappropriate root canal treatment and apical radiolucency. After extraction of mandibular second molar and maxillary third molar (the donor), the tooth was re-implanted into the extracted socket of second molar site...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28177531/recruitment-of-bone-marrow-derived-cells-to-the-periodontal-ligament-via-the-stromal-cell-derived-factor-1-c-x-c-chemokine-receptor-type-4-axis
#3
M Kaku, M Kitami, J M Rosales Rocabado, T Ida, Y Akiba, K Uoshima
BACKGROUND/OBJECTIVES: The periodontal ligament (PDL) is a non-mineralized connective tissue that exists between the alveolar bone and root surface cementum and plays important roles in tooth function. The PDL harbors a remarkable reserve of multipotent stem cells, which maintain various types of cells. However, the sources of these stem cells, other than their developmental origin, are not well understood. MATERIAL AND METHODS: To elucidate the recruitment of bone marrow (BM)-derived stem cells in the PDL, green fluorescent protein (GFP)-expressing BM-derived cells were transplanted into the femoral BM of immunodeficient rats, and the distribution and expression of stem cell markers in the PDL were analyzed in vivo...
February 8, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28168900/a-translational-medicine-approach-to-tooth-transplantation
#4
Giovanpaolo Pini Prato, Giliana Zuccati, Carlo Clauser
No abstract text is available yet for this article.
February 7, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28106505/pulp-vascularization-during-tooth-development-regeneration-and-therapy
#5
C Rombouts, T Giraud, C Jeanneau, I About
The pulp is a highly vascularized tissue situated in an inextensible environment surrounded by rigid dentin walls, with the apical foramina being the only access. The pulp vascular system is not only responsible for nutrient supply and waste removal but also contributes actively to the pulp inflammatory response and subsequent regeneration. This review discusses the underlying mechanisms of pulp vascularization during tooth development, regeneration, and therapeutic procedures, such as tissue engineering and tooth transplantation...
February 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28061389/in-vitro-proliferation-of-periodontal-ligament-like-tissue-on-extracted-teeth
#6
T Iwata, C Mino, T Kawata
OBJECTIVE: Transplantation of autologous teeth is a routine component of orthodontic treatment. The aim of this study was to develop a method for the regeneration of damaged periodontal ligament (PDL) on extracted teeth using a three-dimensional culture system. DESIGN: We used the maxillary first premolars or third molars extracted from patients for orthodontic treatment. The extracted teeth were stained with toluidine blue to measure the residual PDL area. After confirming damage of the periodontal tissue on the root surface of the extracted teeth, we tried to regenerate the periodontal tissue...
November 30, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/28057509/promoting-bioengineered-tooth-innervation-using-nanostructured-and-hybrid-scaffolds
#7
S Kuchler-Bopp, A Larrea, L Petry, Y Idoux-Gillet, V Sebastian, A Ferrandon, P Schwinté, M Arruebo, N Benkirane-Jessel
: The innervation of teeth mediated by axons originating from the trigeminal ganglia is essential for their function and protection. Immunosuppressive therapy using Cyclosporine A (CsA) was found to accelerate the innervation of transplanted tissues and particularly that of bioengineered teeth. To avoid the CsA side effects, we report in this study the preparation of CsA loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles, their embedding on polycaprolactone (PCL)-based scaffolds and their possible use as templates for the innervation of bioengineered teeth...
January 3, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28053317/jawbone-microenvironment-promotes-periodontium-regeneration-by-regulating-the-function-of-periodontal-ligament-stem-cells
#8
Bin Zhu, Wenjia Liu, Yihan Liu, Xicong Zhao, Hao Zhang, Zhuojing Luo, Yan Jin
During tooth development, the jawbone interacts with dental germ and provides the development microenvironment. Jawbone-derived mesenchymal stem cells (JBMSCs) maintain this microenvironment for root and periodontium development. However, the effect of the jawbone microenvironment on periodontium tissue regeneration is largely elusive. Our previous study showed that cell aggregates (CAs) of bone marrow mesenchymal stem cells promoted periodontium regeneration on the treated dentin scaffold. Here, we found that JBMSCs enhanced not only the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) but also their adhesion to titanium (Ti) material surface...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28027709/conditioned-medium-from-periodontal-ligament-stem-cells-enhances-periodontal-regeneration
#9
Mizuki Nagata, Kengo Iwasaki, Keiko Akazawa, Motohiro Komaki, Naoki Yokoyama, Yuichi Izumi, Ikuo Morita
Periodontal disease is one of the most common infectious diseases in adults and is characterized by the destruction of tooth-supporting tissues. Mesenchymal stem cells (MSCs) comprise the mesoderm-originating stem cell population, which has been studied and used for cell therapy. However, because of the lower rate of cell survival after MSC transplantation in various disease models, paracrine functions of MSCs have been receiving increased attention as a regenerative mechanism. The aim of this study was to investigate the regenerative potential of transplanted conditioned medium (CM) obtained from cultured periodontal ligament stem cells (PDLSCs), the adult stem cell population in tooth-supporting tissues, using a rat periodontal defect model...
January 27, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27974406/thrombotic-microangiopathy-in-inverted-formin-2-mediated-renal-disease
#10
Rachel C Challis, Troels Ring, Yaobo Xu, Edwin K S Wong, Oliver Flossmann, Ian S D Roberts, Saeed Ahmed, Michael Wetherall, Giedrius Salkus, Vicky Brocklebank, Julian Fester, Lisa Strain, Valerie Wilson, Katrina M Wood, Kevin J Marchbank, Mauro Santibanez-Koref, Timothy H J Goodship, David Kavanagh
The demonstration of impaired C regulation in the thrombotic microangiopathy (TMA) atypical hemolytic uremic syndrome (aHUS) resulted in the successful introduction of the C inhibitor eculizumab into clinical practice. C abnormalities account for approximately 50% of aHUS cases; however, mutations in the non-C gene diacylglycerol kinase-ε have been described recently in individuals not responsive to eculizumab. We report here a family in which the proposita presented with aHUS but did not respond to eculizumab...
December 14, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27973697/enhanced-regeneration-potential-of-mobilized-dental-pulp-stem-cells-from-immature-teeth
#11
Hidenori Nakayama, Koichiro Iohara, Yuki Hayashi, Yuta Okuwa, Kurita Kenichi, Misako Nakashima
OBJECTIVES: We have previously demonstrated that dental pulp stem cell (DPSCs) isolated from mature teeth by granulocyte-colony stimulating factor (G-CSF)-induced mobilization method can enhance angiogenesis/vasculogenesis and improve pulp regeneration when compared with colony-derived DPSCs. However, the efficacy of this method in immature teeth with root-formative stage has never been investigated. Therefore, the aim of this study is to examine the stemness, biological characteristics and regeneration potential in mobilized-DPSCs compared with colony-derived DPSCs from immature teeth...
December 14, 2016: Oral Diseases
https://www.readbyqxmd.com/read/27925870/hydrogen-sulfide-enhances-pancreatic-%C3%AE-cell-differentiation-from-human-tooth-under-normal-and-glucotoxic-conditions
#12
Ioan Valentin Matei, Hisataka Ii, Ken Yaegaki
AIM: Glucotoxicity obstructs pancreatic differentiation from adult stem cells. The aim was to develop a novel protocol for differentiation of dental pulp stem cells (DPSCs) into pancreatic β cells and determine the effect of H2S on glucotoxicity. MATERIALS & METHODS: DPSCs were differentiated with media containing 5.5 or 25.0 mM glucose, exposed to 1 ng/ml H2S. Glucotoxicity, expression of β-cell markers, INS, PDX1 and GLUT2, and PI3K/AKT pathway were assessed...
December 7, 2016: Regenerative Medicine
https://www.readbyqxmd.com/read/27858309/dental-care-approach-in-patients-with-osteopetrosis
#13
V Detailleur, G Vansteenkiste, M Renard, A Verdonck
AIM: To describe dental and dentofacial characteristics observed in patients diagnosed with osteopetrosis and to advise a dental care approach in these patients. METHODS: Four patients were clinically diagnosed with osteopetrosis, characterised by increased bone density, bone marrow failure, blindness and deafness due to compression of cranial nerves. All patients were dentally screened at different ages (2.5-31 years) and three of them were treated with a haematopoietic stem cell transplantation (HSCT) at the age of 6 months, 1 and 3...
December 2016: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/27776880/guided-autotransplantation-of-teeth-a-novel-method-using-virtually-planned-3-dimensional-templates
#14
Georg D Strbac, Albrecht Schnappauf, Katharina Giannis, Michael H Bertl, Andreas Moritz, Christian Ulm
INTRODUCTION: The aim of this study was to introduce an innovative method for autotransplantation of teeth using 3-dimensional (3D) surgical templates for guided osteotomy preparation and donor tooth placement. METHODS: This report describes autotransplantation of immature premolars as treatment of an 11-year-old boy having suffered severe trauma with avulsion of permanent maxillary incisors. This approach uses modified methods from guided implant surgery by superimposition of Digital Imaging and Communications in Medicine files and 3D data sets of the jaws in order to predesign 3D printed templates with the aid of a fully digital workflow...
December 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/27747624/evaluation-of-implant-materials-as-cell-carriers-for-dental-stem-cells-under-in-vitro-conditions
#15
Martin Gosau, Sandra Viale-Bouroncle, Hannah Eickhoff, Esthera Prateeptongkum, Anja Reck, W Götz, Christoph Klingelhöffer, Steffen Müller, Christian Morsczeck
BACKGROUND: Dental stem cells in combination with implant materials may become an alternative to autologous bone transplants. For tissue engineering different types of soft and rigid implant materials are available, but little is known about the viability and the osteogenic differentiation of dental stem cells on these different types of materials. According to previous studies we proposed that rigid bone substitute materials are superior to soft materials for dental tissue engineering...
December 2015: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/27695327/fabrication-of-gelatin-methacrylate-nanohydroxyapatite-microgel-arrays-for-periodontal-tissue-regeneration
#16
Xi Chen, Shizhu Bai, Bei Li, Huan Liu, Guofeng Wu, Sha Liu, Yimin Zhao
INTRODUCTION: Periodontitis is a chronic infectious disease and is the major cause of tooth loss and other oral health issues around the world. Periodontal tissue regeneration has therefore always been the ultimate goal of dentists and researchers. Existing fabrication methods mainly focused on a top-down tissue engineering strategy in which several drawbacks remain, including low throughput and limited diffusion properties resulting from a large sample size. Gelatin methacrylate (GelMA) is a kind of photocrosslinkable and biocompatible hydrogel, with the capacities of enabling cell encapsulation and regeneration of functional tissues...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27633512/replantation-of-a-displaced-incisor-in-a-boy-with-a-cleft-lip-and-alveolus-a-case-report
#17
Heidrun Schaaf, Heiko Kerkmann, Felix Pitka, Niko Christian Bock, Sameh Attia
BACKGROUND: Tooth replantation after traumatic avulsion or transplantation is a challenge in oral surgery. A special method named auto-alloplastic replantation, in which a titanium post is used after extraoral endodontic treatment, combines several advantages. The treatment is performed in one step with no further endodontic intervention, no wide root canal instrumentation, no recontamination, and reduced endodontic infection. This is the first report on replantation of an ectopic tooth in a patient with a cleft lip and alveolus using this method...
September 15, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27613503/periodontal-regeneration-in-swine-after-cell-injection-and-cell-sheet-transplantation-of-human-dental-pulp-stem-cells-following-good-manufacturing-practice
#18
Jingchao Hu, Yu Cao, Yilin Xie, Hua Wang, Zhipeng Fan, Jinsong Wang, Chunmei Zhang, Jinsong Wang, Chu-Tse Wu, Songlin Wang
BACKGROUND: Periodontitis, one of the most prevalent infectious diseases in humans, results in the destruction of tooth-supporting tissues. The purpose of the present study is to evaluate the effect of cell injection and cell sheet transplantation on periodontal regeneration in a swine model. METHODS: In the present study, human dental pulp stem cells (hDPSCs) were transplanted into a swine model for periodontal regeneration. Twelve miniature pigs were used to generate periodontitis with bone defects of 5 mm in width, 7 mm in length, and 3 mm in depth...
September 9, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27599698/transplantation-of-osteoporotic-bone-marrow-stromal-cells-rejuvenated-by-the-overexpression-of-satb2-prevents-alveolar-bone-loss-in-ovariectomized-rats
#19
Rongyao Xu, Zongyun Fu, Xue Liu, Tao Xiao, Ping Zhang, Yifei Du, Hua Yuan, Jie Cheng, Hongbing Jiang
Estrogen-deficient osteoporosis is an aging-related disease with high morbidity that not only significantly increases a woman's risk of fragility fracture but is also associated with tooth and bone loss in the supporting alveolar bone of the jaw. Emerging evidence suggests that the aging of bone marrow stromal cells (BMSCs) contributes to the development of osteoporosis. In this study, we aimed to investigate the role of the special AT-rich sequence-binding protein 2 (SATB2), a stemness and senescence regulator of craniofacial BMSCs, in rat ovariectomy-induced alveolar osteoporosis...
November 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27594561/gingiva-as-a-new-and-the-most-accessible-source-of-mesenchymal-stem-cells-from-the-oral-cavity-to-be-used-in-regenerative-therapies
#20
Bartłomiej Górski
Since the discovery of bone marrow mesenchymal stem cells (BMMSCs), many researchers have focused their attention on new sources of mesenchymal stem cells (MSCs). Consequently, MSCs that display self-renewal capacity, multidifferentiation potential and immunomodulatory properties have been isolated from human oral tissues, including tooth, periodontal ligament, and gingiva. Oral MSCs involve dental pulp stem cells (DPSCs), stem cells from exfoliated deciduous teeth (SHED), periodontal ligament stem cells (PDLSCs), dental follicle stem cells (DFCs), stem cells from apical papilla (SCAP) and gingival stem cells (GMSCs)...
August 17, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
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