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Tooth transplant

Martin Gosau, Sandra Viale-Bouroncle, Hannah Eickhoff, Esthera Prateeptongkum, Anja Reck, W Götz, Christoph Klingelhöffer, Steffen Müller, Christian Morsczeck
BACKGROUND: Dental stem cells in combination with implant materials may become an alternative to autologous bone transplants. For tissue engineering different types of soft and rigid implant materials are available, but little is known about the viability and the osteogenic differentiation of dental stem cells on these different types of materials. According to previous studies we proposed that rigid bone substitute materials are superior to soft materials for dental tissue engineering...
December 2015: Int J Implant Dent
Xi Chen, Shizhu Bai, Bei Li, Huan Liu, Guofeng Wu, Sha Liu, Yimin Zhao
INTRODUCTION: Periodontitis is a chronic infectious disease and is the major cause of tooth loss and other oral health issues around the world. Periodontal tissue regeneration has therefore always been the ultimate goal of dentists and researchers. Existing fabrication methods mainly focused on a top-down tissue engineering strategy in which several drawbacks remain, including low throughput and limited diffusion properties resulting from a large sample size. Gelatin methacrylate (GelMA) is a kind of photocrosslinkable and biocompatible hydrogel, with the capacities of enabling cell encapsulation and regeneration of functional tissues...
2016: International Journal of Nanomedicine
Heidrun Schaaf, Heiko Kerkmann, Felix Pitka, Niko Christian Bock, Sameh Attia
BACKGROUND: Tooth replantation after traumatic avulsion or transplantation is a challenge in oral surgery. A special method named auto-alloplastic replantation, in which a titanium post is used after extraoral endodontic treatment, combines several advantages. The treatment is performed in one step with no further endodontic intervention, no wide root canal instrumentation, no recontamination, and reduced endodontic infection. This is the first report on replantation of an ectopic tooth in a patient with a cleft lip and alveolus using this method...
2016: Journal of Medical Case Reports
Jingchao Hu, Yu Cao, Yilin Xie, Hua Wang, Zhipeng Fan, Jinsong Wang, Chunmei Zhang, Jinsong Wang, Chu-Tse Wu, Songlin Wang
BACKGROUND: Periodontitis, one of the most prevalent infectious diseases in humans, results in the destruction of tooth-supporting tissues. The purpose of the present study is to evaluate the effect of cell injection and cell sheet transplantation on periodontal regeneration in a swine model. METHODS: In the present study, human dental pulp stem cells (hDPSCs) were transplanted into a swine model for periodontal regeneration. Twelve miniature pigs were used to generate periodontitis with bone defects of 5 mm in width, 7 mm in length, and 3 mm in depth...
2016: Stem Cell Research & Therapy
Rongyao Xu, Zongyun Fu, Xue Liu, Tao Xiao, Ping Zhang, Yifei Du, Hua Yuan, Jie Cheng, Hongbing Jiang
Estrogen-deficient osteoporosis is an aging-related disease with high morbidity that not only significantly increases a woman's risk of fragility fracture but is also associated with tooth and bone loss in the supporting alveolar bone of the jaw. Emerging evidence suggests that the aging of bone marrow stromal cells (BMSCs) contributes to the development of osteoporosis. In this study, we aimed to investigate the role of the special AT-rich sequence-binding protein 2 (SATB2), a stemness and senescence regulator of craniofacial BMSCs, in rat ovariectomy-induced alveolar osteoporosis...
November 2016: Experimental Gerontology
Bartłomiej Górski
Since the discovery of bone marrow mesenchymal stem cells (BMMSCs), many researchers have focused their attention on new sources of mesenchymal stem cells (MSCs). Consequently, MSCs that display self-renewal capacity, multidifferentiation potential and immunomodulatory properties have been isolated from human oral tissues, including tooth, periodontal ligament, and gingiva. Oral MSCs involve dental pulp stem cells (DPSCs), stem cells from exfoliated deciduous teeth (SHED), periodontal ligament stem cells (PDLSCs), dental follicle stem cells (DFCs), stem cells from apical papilla (SCAP) and gingival stem cells (GMSCs)...
2016: Postȩpy Higieny i Medycyny Doświadczalnej
Zhaoming Wu, Don Jeevanie Epasinghe, Jinquan He, Liwen Li, David W Green, Min-Jung Lee, Han-Sung Jung
Vangl2, one of the core components of the planar cell polarity (PCP) pathway, has an important role in the regulation of morphogenesis in several tissues. Although the expression of Vangl2 has been detected in the developing tooth, its role in tooth morphogenesis is not known. In this study, we show that Vangl2 is expressed in the inner dental epithelium (IDE) and in the secondary enamel knots (SEKs) of bell stage tooth germs. Inhibition of Vangl2 expression by siRNA treatment in in vitro-cultured tooth germs resulted in retarded tooth germ growth with deregulated cell proliferation and apoptosis...
September 3, 2016: Cell and Tissue Research
Miguel Rodrigues Martins, Rita C Lima, Irene Pina-Vaz, Manuel Fontes Carvalho, Norbert Gutknecht
OBJECTIVE AND BACKGROUND: Although several surgical techniques have been reported, no study has yet reported alternative strategies for endodontic treatment of autogenous transplanted teeth. Therefore, the aim of this clinical report is to present the long-term endodontic outcome of a nonvital autogenously transplanted third molar treated with an Er,Cr:YSGG laser and radial firing tips (RFTs). CASE REPORT: Autogenous tooth transplantation can be considered an alternative to restore edentulous areas and, in donor's teeth with complete root formation, root canal treatment should be performed up to 14 days following transplantation...
October 2016: Photomedicine and Laser Surgery
Gerhard Schmalz, Anne Kauffels, Otto Kollmar, Jan E Slotta, Radovan Vasko, Gerhard A Müller, Rainer Haak, Dirk Ziebolz
BACKGROUND: Aim of this single center cross-sectional study was to investigate oral behavior, dental, periodontal and microbiological findings in patients undergoing hemodialysis (HD) and after kidney transplantation (KT). METHODS: Patients undergoing HD for end-stage renal failure and after KT were investigated. Oral health behavior was recorded using a standardized questionnaire, e.g. dental behavior, tooth brushing, oral hygiene aids. Oral investigation included screening of oral mucosa, dental findings (DMF-T) and periodontal situation (Papilla bleeding index [PBI] periodontal probing depth [PPD] and clinical attachment loss [CAL])...
2016: BMC Oral Health
Marjolijn Gilijamse, Jacobus A Baart, Jan Wolff, George K Sándor, Tymour Forouzanfar
OBJECTIVE: This retrospective study evaluated survival rates, prognosis, and overall success of autotransplanted teeth in young patients missing anterior teeth as a result of trauma, agenesis, or developmental disturbances. STUDY DESIGN: Retrospective data were collected from the medical records of patients who had undergone tooth autotransplantations to anterior sites between January 2001 and December 2012. Clinical variables, such as gender, age, surgical indications, donor and recipient sites, type of anesthetics, bone augmentation, and complications during follow-up, were assessed...
June 29, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Takaaki Tsunematsu, Natsumi Fujiwara, Maki Yoshida, Yukihiro Takayama, Satoko Kujiraoka, Guangying Qi, Masae Kitagawa, Tomoyuki Kondo, Akiko Yamada, Rieko Arakaki, Mutsumi Miyauchi, Ikuko Ogawa, Yoshihiro Abiko, Hiroki Nikawa, Shinya Murakami, Takashi Takata, Naozumi Ishimaru, Yasusei Kudo
Epithelial cell rests of Malassez (ERM) are quiescent epithelial remnants of the Hertwig's epithelial root sheath (HERS) that are involved in the formation of tooth roots. ERM cells are unique epithelial cells that remain in periodontal tissues throughout adult life. They have a functional role in the repair/regeneration of cement or enamel. Here, we isolated odontogenic epithelial cells from ERM in the periodontal ligament, and the cells were spontaneously immortalized. Immortalized odontogenic epithelial (iOdE) cells had the ability to form spheroids and expressed stem cell-related genes...
October 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
Frank Schwarz, Andrea Schmucker, Jürgen Becker
OBJECTIVES: Recent animal studies have indicated, that tooth roots reveal a structural and biological potential to serve as alternative autografts for localized ridge augmentation. This proof-of-concept initial report aimed at investigating, whether this new surgical concept may be applied to humans. MATERIAL & METHODS: In one patient, who was in need for horizontal ridge augmentation, the roots of a retained upper wisdom tooth were separated and rigidly fixed at the defect site...
November 2016: Journal of Clinical Periodontology
J P Verweij, D Anssari Moin, G Mensink, D Wismeijer, J P R van Merkesteyn
Autotransplantation is a valuable technique offering a physiological type of tooth replacement to patients with missing teeth. Teeth with open apices (50-75% apical closure) will regenerate with vitality following autotransplantation. The success rate following an autotransplantation is 82%. The remaining 18% can usually still be treated successfully with a simple additional treatment. The tooth survival rate 10 years after autotransplantation is higher than 90%. The use of 3D techniques makes it possible to create a pre-operative replica of the donor tooth...
July 2016: Nederlands Tijdschrift Voor Tandheelkunde
Rei Kawamura, Yuki Hayashi, Hiroshi Murakami, Misako Nakashima
BACKGROUND: The critical challenge in tissue engineering is to establish an optimal combination of stem cells, signaling morphogenetic molecules, and extracellular matrix scaffold/microenvironment. The extracellular matrix components of teeth may be reconstituted as an inductive microenvironment in an ectopic tooth transplantation bioassay. Thus, the isolation and identification of the chemical components of the inductive microenvironment in pulp/dentin regeneration will accelerate progress towards the goal of tissue engineering of the tooth...
2016: Stem Cell Research & Therapy
Sunil Kim, Su-Jung Shin, Jeong-Won Park, Sunjai Kim, Soonshin Hwang, Kyung-Ho Kim, Chooryung J Chung
Autotransplantation is a viable treatment option for tooth replacement when a suitable donor tooth is available. This case report presents 2 cases that describe successful treatment outcome and prognosis after autotransplantation of a mature premolar as a missing molar. The first premolar was extracted for orthodontic purposes and transplanted to the missing first molar site in the mandible. The transplanted tooth was monitored up to 7 years. The transplant was functional and maintained a normal bone level throughout the follow-up period...
August 2016: Journal of Endodontics
Hiromitsu Morita, Yuko Imai, Masahiro Yoneda, Takao Hirofuji
Bisphosphonates and irradiation are useful medical treatments, but can often cause oral complications such as medication-related oral necrosis of the jaw (MRONJ) and osteoradionecrosis (ORN) during oral surgery, including tooth extraction. Therefore, we should take all risks into consideration carefully before choosing dental treatment for patients with a medical history of such therapies. A 55-year-old woman who underwent cord blood transplantation to treat extranodal natural killer T (NK/T) cell lymphoma (nasal type IVB) had a medical history of bisphosphonate and irradiation treatments...
June 30, 2016: Special Care in Dentistry
Shakil Ahmed Nagori, Anson Jose, Ankit Arora, Sahil Gagnani, Yatin Kholakiya, Bhaskar Agarwal, Ongkila Bhutia, Ajoy Roychoudhury
AIM: The aim of this cross-sectional study was to assess knowledge regarding autogenous tooth transplantation among oral and maxillofacial surgery (OMFS) residents in India. STUDY DESIGN: The sample of the survey consisted of Indian OMFS post-graduate residents attending the "1st Asian Oral and Maxillofacial Surgery PG Convention" held from 29th to 31st August, 2013 at Mangalore, India. Questions were asked regarding the participant's preferred tooth replacement modality, the transplantation procedure (socket preparation and stabilization of transplanted tooth); fate of the transplanted tooth (pulpal and periodontal fate) and the possibility of replacing second molars with such procedure, cross-arch transplantation and transplantation after new-socket preparation...
June 2016: Journal of Maxillofacial and Oral Surgery
Reinhard E Friedrich, Hanna A Scheuer, Wolf Höltje
Odontogenic myxoma (OM) is a rare tumour arising in the jaws. The tumour is purported to be odontogenic in origin due to the frequent localisation of the tumour inside the jaws in close relation to teeth. The aim of this report was to detail the course of a patient who developed OM of the maxilla, underwent adequate ablative surgery and reconstruction, including tooth transplantation to the original tumour site, and subsequently developed a local recurrence in close proximity to the teeth transplanted to the reconstructed maxilla 6 years after the first diagnosis...
June 2016: Anticancer Research
Ola M Maria, Younan Liu, Michel El-Hakim, Anthony Zeitouni, Simon D Tran
Head and neck cancer patients treated with radiotherapy commonly experience hyposalivation and oral/tooth infections, leading to a reduced quality of life. Clinical management is currently unsatisfactory for dry mouth. Thus, there is a need for growing salivary fluid-secreting (acinar) cells for these patients. However, functionally-grown salivary acinar cells are cultured in Matrigel, a product that cannot be used clinically, owing to its source from a mouse sarcoma. Therefore, finding a gel suitable for clinical use and possessing properties similar to that of Matrigel would allow biopsied salivary cells to be expanded in vitro and transplanted into the mouths of xerostomic patients...
May 3, 2016: Journal of Tissue Engineering and Regenerative Medicine
Paweł Plakwicz, Piotr Fudalej, Ewa Monika Czochrowska
INTRODUCTION: Agenesis of a maxillary lateral incisor occurs in about 2% of the population. Treatment options should adapt to natural biologic changes in a lifelong perspective. METHODS AND RESULTS: A young woman with bilateral agenesis of the maxillary lateral incisors was treated with transplantation of a developing maxillary third molar on one side and a dental implant on the contralateral side, after orthodontic space opening. The periodontal examination, including bacterial testing of the transplant, the implant, and the control central incisor, was performed 9 years after the treatment...
May 2016: American Journal of Orthodontics and Dentofacial Orthopedics
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