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https://www.readbyqxmd.com/read/29346834/twelve-week-ravidasvir-plus-ritonavir-boosted-danoprevir-and-ribavirin-for-non-cirrhotic-hcv-genotype-1-patients-a-phase-2-study
#1
Jia-Horng Kao, Min-Lung Yu, Chi-Yi Chen, Cheng-Yuan Peng, Ming-Yao Chen, Huoling Tang, Qiaoqiao Chen, Jinzi J Wu
BACKGROUND AND AIM: The need for all-oral HCV treatments with higher response rates, improved tolerability and lower pill burden compared to interferon-inclusive regimen has led to the development of new direct-acting antiviral agents (DAAs). Ravidasvir (RDV) is a second-generation, pan-genotypic NS5A inhibitor with high barrier to resistance. The aim of this phase 2 study (EVERST study) was to assess the efficacy and safety of interferon-free, 12-week RDV plus ritonavir-boosted danoprevir (DNVr) and ribavirin (RBV) regimen for treatment-naïve Asian HCV genotype 1 (GT1) patients without cirrhosis...
January 18, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29346367/assessment-of-serum-pharmacokinetics-and-urinary-excretion-of-albendazole-and-its-metabolites-in-human-volunteers
#2
Laura Ceballos, Alejandro Krolewiecki, Marisa Juárez, Laura Moreno, Fabian Schaer, Luis I Alvarez, Rubén Cimino, Judd Walson, Carlos E Lanusse
BACKGROUND: Soil Transmitted Helminth (STH) infections negatively impact physical and mental development in human populations. Current WHO guidelines recommend morbidity control of these infections through mass drug administration (MDA) using albendazole (ABZ) or mebendazole. Despite major reductions in STH associated morbidity globally, not all programs have demonstrated the expected impact on prevalence of parasite infections. These therapeutic failures may be related to poor programmatic coverage, suboptimal adherence or the exposure of parasites to sub-therapeutic drug concentrations...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29345165/oral-contraceptive-pills-as-an-option-for-non-surgical-management-of-retained-products-of-conception-a-preliminary-study
#3
Anat Hershko Klement, Mitri Frederic, Yaakov Bentov, Paul Chang, Dan Nayot, Jigal Haas, Robert F Casper
Many Patients with persistent retained products of conception prefers to avoid surgical interventions, such as a dilatation and curettage (D&C) that might pose an additional future risk to their already compromised fertility or obstetric performance. The aim of this study was to the possibility of induced withdrawal bleeding following oral contraceptive administration as a non-surgical treatment for patients with persistent retained products of conception (RPOC). A retrospective study of patients presenting with retained products of conception (RPOC) after failed expectant management or after treatment with PGE1 was performed...
January 18, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29345111/association-between-hepatitis-c-infection-in-thai-patients-with-oral-lichen-planus-a-case-control-study
#4
Trin Manomaivat, Surawut Pongsiriwet, Chatsri Kuansuwan, Wacharaporn Thosaporn, Kathawut Tachasuttirut, Anak Iamaroon
AIM: The aim of the present study was to investigate the prevalence of hepatitis C virus (HCV) infection and evaluate liver enzyme levels in patients from upper northern Thailand with oral lichen planus (OLP). METHODS: A case-control study of 101 patients with OLP and 101 patients without OLP was conducted. Peripheral blood was taken from each patient and screened for anti-HCV antibody using immunochromatography. Positive samples were further confirmed using chemiluminescent microparticle immunoassay (CMIA) and reverse transcription-polymerase chain reaction...
January 18, 2018: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/29344938/a-clinical-audit-on-the-efficacy-and-safety-of-uterine-artery-embolisation-for-symptomatic-adenomyosis-results-in-117-women
#5
Eisen Liang, Bevan Brown, Maxim Rachinsky
BACKGROUND: Uterine artery embolisation (UAE) is a possible uterine-sparing treatment option for women with unsuccessful conservative management for adenomyosis-related heavy menstrual bleeding (HMB) and dysmenorrhoea. AIM: To conduct a clinical audit on the efficacy and safety of UAE for symptomatic adenomyosis. MATERIALS AND METHODS: Retrospective review of 309 women who underwent UAE identified 117 women with magnetic resonance imaging features of adenomyosis (junctional zone thickness ≥ 12 mm)...
January 18, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29344911/recurrent-infectious-subcapsular-renal-hematoma-accompanied-by-microaneurysm
#6
Toshikazu Ozeki, Junichiro Yamamoto, Shigeki Yamamoto, Chisato Shigematsu, Masashi Tsuji
An 80-year-old woman was admitted to the hospital complaining of loss of appetite. 10 days earlier, her oral intake gradually decreased with no other specific symptoms, such as abdominal pain, nausea, vomiting, headache, or low back pain. Abdominal computed tomography (CT) scan revealed a left subcapsular renal hematoma. We suspected infective subcapsular renal hematoma, so percutaneous needle aspiration and drainage were performed. Intravenous sulbactam-ampicillin was started immediately. On day 9 after admission, repeat CT scan revealed the subcapsular hematoma had reduced in size...
January 17, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29344081/hpv-infection-and-p16-expression-in-oral-and-oropharyngeal-cancer-in-kazakhstan
#7
Dauren Adilbay, Galim Adilbayev, Gulzhan Kidirbayeva, Viktoria Shipilova, Zhanat Sadyk, Gulsum Koyanbekova, Ekaterina Sokolenko, Jan Klozar
Background: Human papillomavirus (HPV) is an important etiologic factor in different cancers of anogenital region and also in a fraction of head and neck cancers (HNC) particularly oropharyngeal tumors. The HPV16 genotype associated with the majority of HPV-related head and neck carcinomas. Th incidence of oropharyngeal cancer is increasing in many countries, and the rate of HPV positive tumors is about 70% in Europe and North America. Little known about the prevalence of HPV in HNC in Central Asia...
2018: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29343582/hiv-replication-and-latency-in-a-humanized-nsg-mouse-model-during-suppressive-oral-combinational-art
#8
Sangeetha Satheesan, Haitang Li, John C Burnett, Mayumi Takahashi, Shasha Li, Shiny Xiaqin Wu, Timothy W Synold, John J Rossi, Jiehua Zhou
Although current combinatorial antiretroviral therapy (cART) is therapeutically effective in the majority of HIV patients, interruption of therapy can cause a rapid rebound in viremia, demonstrating the existence of a stable reservoir of latently infected cells. HIV latency is therefore considered a primary barrier to HIV eradication. Identifying, quantifying, and purging the HIV reservoir is crucial to effectively curing patients and relieving them from the lifelong requirement for therapy. Latently infected transformed cell models have been used to investigate HIV latency; however, they cannot accurately represent the quiescent cellular environment of primary latently infected cells in vivo...
January 17, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29343304/increasing-incidence-of-dirofilaria-immitis-in-dogs-in-usa-with-focus-on-the-southeast-region-2013-2016
#9
Jason Drake, Scott Wiseman
BACKGROUND: A recent American Heartworm Society (AHS) survey on the incidence of adult heartworm infections in dogs in the United States of America showed a 21.7% increase in the average cases per veterinary clinic from 2013 to 2016. The analysis reported here was performed to see if heartworm testing results available via the Companion Animal Parasite Council (CAPC) aligned with the AHS survey and whether changes in heartworm preventive dispensing accounts for the increased incidence...
January 17, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29343131/safety-and-tolerability-of-plecanatide-in-patients-with-chronic-idiopathic-constipation-long-term-evidence-from-an-open-label-study
#10
Charles F Barish, Patrick Griffin
OBJECTIVE: This multicenter, fixed-dose, open-label study evaluated the long-term safety and tolerability of once-daily oral plecanatide for the treatment of adults with chronic idiopathic constipation (CIC). METHODS: Eligible patients completed a phase 2b or phase 3 double-blind study of plecanatide, or had not previously been treated with plecanatide. Enrolled patients received plecanatide (3 or 6 mg) for up to 72 weeks. Safety and tolerability were assessed by the incidence, nature, and severity of spontaneously reported treatment-emergent adverse events (TEAEs)...
January 17, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29342358/synthesis-and-biological-characterization-of-aryl-uracil-inhibitors-of-hepatitis-c-virus-ns5b-polymerase-discovery-of-abt-072-a-trans-stilbene-analog-with-good-oral-bioavailability
#11
John Randolph, A Chris Krueger, Pamela Donner, John K Pratt, Dachun Liu, Christopher E Motter, Todd W Rockway, Mike D Tufano, Rolf Wagner, Hock B Lim, Jill M Beyer, Rubina Mondal, Neeta S Panchal, Lynn Colletti, Yaya Liu, Gennadiy Koev, Warren M Kati, Lisa E Hernandez, David W A Beno, Kenton L Longenecker, Kent D Stewart, Emily O Dumas, Akhteruzzaman Molla, Clarence Maring
ABT-072 is a non-nucleoside HCV NS5B polymerase inhibitor that was discovered as part of a program to identify new direct-acting antivirals (DAAs) for the treatment of HCV infection. This compound was identified during a medicinal chemistry effort to improve on an original lead, inhibitor 1, which we described in a previous publication. Replacement of the amide linkage in 1 with a trans-olefin resulted in improved compound permeability and solubility, and provided much better pharmacokinetic properties in preclinical species...
January 17, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29341942/enteritis-associated-acute-febrile-neutrophilic-dermatosis-with-acute-monoarthritis
#12
Stamatis S Papadatos, Christos Zissis, Georgios Deligiannis, Stefanos Mylonas
Febrile neutrofilic dermatosis is an uncommon entity with complex pathophysiology, usually secondary to an infection, a malignancy or an autoimmune disease. Extracutaneous manifestations of the disease are very rare as well. We report a patient with histologically confirmed acute febrile neutrophilic dermatosis caused by viral enteritis that was presented with painful rash along with acute monoarthritis and treated with oral corticosteroids.
December 20, 2017: Folia Medica
https://www.readbyqxmd.com/read/29341890/periodontal-diseases-and-adverse-pregnancy-outcomes-is-there-a-role-for-vitamin-d
#13
REVIEW
Anne Marie Uwitonze, Peace Uwambaye, Moses Isyagi, Chrispinus H Mumena, Alice Hudder, Afrozul Haq, Kamrun Nessa, Mohammed S Razzaque
Studies have shown a relationship between maternal periodontal diseases (PDs) and premature delivery. PDs are commonly encountered oral diseases which cause progressive damage to the periodontal ligament and alveolar bones, leading to loss of teeth and oral disabilities. PDs also adversely affect general health by worsening cardiovascular and metabolic diseases. Moreover, maternal PDs are thought to be related to increasing the frequency of preterm-birth with low birth weight (PBLBW) new-borns. Prematurity and immaturity are the leading causes of prenatal and infant mortality and is a major public health problem around the world...
January 13, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29339459/a-novel-two-component-system-of-streptococcus-sanguinis-affecting-functions-associated-with-viability-in-saliva-and-biofilm-formation
#14
Tarsila M Camargo, Rafael N Stipp, Lívia A Alves, Erika N Harth-Chu, José F Höfling, Renata O Mattos-Graner
Streptococcus sanguinis is a pioneer species of teeth and a common opportunistic pathogen of infective endocarditis. In this study, we identified a two-component system, SptRS Ss , affecting S. sanguinis survival in saliva and biofilm formation. Isogenic mutants of sptRSs (SKsptR) and sptSSs (SKsptS) showed reduced cell counts in ex vivo assays of viability in saliva, compared to parent strain SK36 and complemented mutants. Reduced counts of the mutants in saliva were associated with reduced growth rates in poor nutrient medium (RPMI) and increased susceptibility to deposition of C3b and MAC of the complement system, a defense component of saliva and serum...
January 16, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29339415/genome-wide-identification-by-transposon-insertion-sequencing-of-escherichia-coli-k1-genes-essential-for-in-vitro-growth-gastrointestinal-colonizing-capacity-and-survival-in-serum
#15
Alex J McCarthy, Richard A Stabler, Peter W Taylor
Escherichia coli K1 strains are major causative agents of invasive disease of the new born. The age dependency of infection can be reproduced in the neonatal rat. Colonization of the small intestine following oral administration of K1 bacteria leads rapidly to invasion of the blood circulation; bacteria that avoid capture by the mesenteric lymphatic system and evade antibacterial mechanisms in the blood may disseminate to cause organ-specific infections such as meningitis. Some E. coli K1 surface constituents, in particular the polysialic acid capsule, are known to contribute to invasive potential but a comprehensive picture of the factors that determine the fully virulent phenotype has not so far emerged...
January 16, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29339395/efficacy-and-safety-of-finafloxacin-versus-ciprofloxacin-in-the-treatment-of-complicated-urinary-tract-infections-an-explorative-randomized-phase-ii-clinical-study
#16
F Wagenlehner, M Nowicki, C Bentley, M Lückermann, S Wohlert, C Fischer, A Vente, K Naber, A Dalhoff
INTRODUCTION: The broad spectrum C-8-cyano-fluoroquinolone finafloxacin displays enhanced activity at acidic conditions. This phase II clinical study compared efficacy and safety of finafloxacin and ciprofloxacin in patients with complicated urinary tract infection and/or pyelonephritis. RESULTS: A 5-day regimen with finafloxacin 800 mg q.d. (FINA05) had similar results as a 10-day regimen with finafloxacin 800 mg q.d. (FINA10). Combined microbiological and clinical responses at test of cure visit (TOC) were 70% for FINA05, 68% for FINA10, and 57% for a 10-day ciprofloxacin regimen (CIPRO10) in 193 (64 for FINA05, 68 for FINA10 and 61 for CIPRO10) patients of the microbiological intent-to-treat (mITT) population...
January 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29339394/population-pharmacokinetics-of-finafloxacin-in-healthy-volunteers-and-patients-with-complicated-urinary-tract-infections
#17
Max Taubert, Mark Lückermann, Andreas Vente, Axel Dalhoff, Uwe Fuhr
Background: Finafloxacin is a novel fluoroquinolone with increased antibacterial activity at acidic pH and reduced susceptibility to several resistance mechanisms. A phase II study revealed a good efficacy/safety profile in patients with complicated urinary tract infections (cUTI) while pharmacokinetics was characterized by highly variable concentration vs. time profiles, suggesting the need for an elaborated pharmacokinetic model.Methods: Data from three clinical trials were evaluated; 127 healthy volunteers were dosed orally (N=77) or intravenously (N=50) and 139 patients with cUTI received finafloxacin intravenously...
January 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29339307/anticoccidial-activity-of-fruit-peel-of-punica-granatum-l
#18
Shazia Ahad, Syed Tanveer, Tauseef Ahmad Malik, Irshad Ahmad Nawchoo
In the interests of food safety and public health, plants and their compounds are now re-emerging as an alternative approach to treat parasitic diseases. Here, we studied the anticoccidial effect of different solvent extracts of the fruit peel of Punica granatum-a commercial waste from pomegranate juice industries. The hope underlying these experiments was to find a sustainable natural product for controlling coccidiosis. The plant extracts were prepared using solvents of different polarity. Acute oral toxicity study was first carried out to see the safety of crude extracts...
January 12, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29339097/safety-and-preliminary-efficacy-of-venetoclax-with-decitabine-or-azacitidine-in-elderly-patients-with-previously-untreated-acute-myeloid-leukaemia-a-non-randomised-open-label-phase-1b-study
#19
Courtney D DiNardo, Keith W Pratz, Anthony Letai, Brian A Jonas, Andrew H Wei, Michael Thirman, Martha Arellano, Mark G Frattini, Hagop Kantarjian, Relja Popovic, Brenda Chyla, Tu Xu, Martin Dunbar, Suresh K Agarwal, Rod Humerickhouse, Mack Mabry, Jalaja Potluri, Marina Konopleva, Daniel A Pollyea
BACKGROUND: Elderly patients (aged ≥65 years) with acute myeloid leukaemia have poor outcomes and no effective standard-of-care therapy exists. Treatment with hypomethylating agents such as azacitidine and decitabine is common, but responses are modest and typically short-lived. The oral anti-apoptotic B-cell lymphoma 2 protein inhibitor, venetoclax, has shown promising single-agent activity in patients with relapsed or refractory acute myeloid leukaemia and preclinical data suggested synergy between hypomethylating agents and venetoclax, which led to this combination phase 1b study...
January 12, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29338726/a-case-of-blackwater-fever-with-persistent-plasmodium-falciparum-parasitaemia-detected-by-pcr-after-artemether-lumefantrine-treatment
#20
Paul John Huggan, Chin Hin Ng, Jennifer Ho, Raymond Tzer Pin Valentine Lin, Jean-Marc Chavatte
BACKGROUND: Blackwater fever is a complication of malaria infection consisting of a syndrome of febrile intra-vascular haemolysis with severe anaemia and intermittent passage of dark-red to black colour urine. Despite numerous reports and studies of this condition, its pathogenesis remains incompletely understood. CASE PRESENTATION: This report describes a case of classic blackwater fever in a returning traveller, without prior history of malaria infection nor usage of anti-malarial prophylaxis, treated with two courses of oral artemether-lumefantrine combination therapy...
January 16, 2018: Malaria Journal
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