keyword
https://read.qxmd.com/read/37986997/biologic-and-clinical-features-of-childhood-gamma-delta-t-all-identification-of-stag2-lmo2-%C3%AE-%C3%AE-t-all-as-an-extremely-high-risk-leukemia-in-the-very-young
#21
Shunsuke Kimura, Petri Polonen, Lindsey Montefiori, Chun Shik Park, Ilaria Iacobucci, Allen Ej Yeoh, Andishe Attarbaschi, Andrew S Moore, Anthony Brown, Atsushi Manabe, Barbara Buldini, Burgess B Freeman, Chelsey Chen, Cheng Cheng, Chiew Kean Hui, Chi-Kong Li, Ching-Hon Pui, Chunxu Qu, Daisuke Tomizawa, David T Teachey, Elena Varotto, Elisabeth M Paietta, Elizabeth D Arnold, Franco Locatelli, Gabriele Escherich, Hannah Elisa Muhle, Hanne Vibeke Marquart, Hester A de Groot-Kruseman, Jacob M Rowe, Jan Stary, Jan Trka, John Kim Choi, Jules P P Meijerink, Jun J Yang, Junko Takita, Katarzyna Pawinska-Wasikowska, Kathryn G Roberts, Katie Han, Kenneth J Caldwell, Kjeld Schmiegelow, Kristine R Crews, Mariko Eguchi, Martin Schrappe, Martin Zimmerman, Masatoshi Takagi, Mellissa Maybury, Michael Svaton, Michaela Reiterova, Michal Kicinski, Mollie S Prater, Motohiro Kato, Noemi Reyes, Orietta Spinelli, Paul Thomas, Pauline Mazilier, Qingsong Gao, Riccardo Masetti, Rishi S Kotecha, Rob Pieters, Sarah Elitzur, Selina M Luger, Sharnise Mitchell, Shondra M Pruett-Miller, Shuhong Shen, Sima Jeha, Stefan Köhrer, Steven M Kornblau, Szymon Skoczeń, Takako Miyamura, Tiffaney L Vincent, Toshihiko Imamura, Valentino Conter, Yanjing Tang, Yen-Chun Liu, Yunchao Chang, Zhaohui Gu, Zhongshan Cheng, Zhou Yinmei, Hiroto Inaba, Charles G Mullighan
PURPOSE: Gamma delta T-cell receptor-positive acute lymphoblastic leukemia (γδ T-ALL) is a high-risk but poorly characterized disease. METHODS: We studied clinical features of 200 pediatric γδ T-ALL, and compared the prognosis of 93 cases to 1,067 protocol-matched non-γδ T-ALL. Genomic features were defined by transcriptome and genome sequencing. Experimental modeling was used to examine the mechanistic impacts of genomic alterations...
November 8, 2023: medRxiv
https://read.qxmd.com/read/37956333/clinical-inquiry-in-nursing-readiness-fellowship-increasing-air-force-nurse-corps-evidence-based-practice-leadership-infrastructure
#22
JOURNAL ARTICLE
Laurie Migliore, Savannah Jumpp, Amanda Fox, Sarah Huffman, Holly Holko, Carla Wiese, Dawn Grant, Theresa Bedford, Enesha Hicks, Jacqueline Killian
BACKGROUND: Increasing demands to generate, translate, and implement evidence into practice in manpower and budget-constrained environments triggered innovative support for the nursing scientific community. The Clinical Inquiry in Nursing Readiness (CINR) fellowship is a solution to integrate readiness into clinical inquiry priorities and develop future experts in the field. METHODS: This article describes the fellowship program structure, implementation, and contributions to nursing science, readiness, and professional development...
November 10, 2023: Military Medicine
https://read.qxmd.com/read/37937645/preliminary-results-of-the-european-multicentric-phase-iii-trial-regarding-sirolimus-in-slow-flow-vascular-malformations
#23
JOURNAL ARTICLE
Emmanuel Seront, An Van Damme, Catherine Legrand, Annouk Bisdorff-Bresson, Philippe Orcel, Thomas Funck-Brentano, Marie-Antoinette Sevestre, Anne Dompmartin, Isabelle Quere, Pascal Brouillard, Nicole Revencu, Martina De Bortoli, Frank Hammer, Philippe Clapuyt, Dana Dumitriu, Miikka Vikkula, Laurence M Boon
BACKGROUNDSlow-flow vascular malformations frequently harbor activating mutations in the PI3K/AKT/mTOR cascade. Phase II trials pinpointed sirolimus effectiveness as a drug therapy. Efficacy and safety of sirolimus thus need to be evaluated in large prospective phase III trials.METHODSThe Vascular Anomaly-Sirolimus-Europe (VASE) trial, initiated in 2016, is a large multicentric prospective phase III trial (EudraCT 2015-001703-32), which evaluates efficacy and safety of sirolimus for 2 years in pediatric and adult patients with symptomatic slow-flow vascular malformations...
November 8, 2023: JCI Insight
https://read.qxmd.com/read/37922343/role-of-fellowship-training-in-furthering-innovations-in-perioperative-neuroscience
#24
JOURNAL ARTICLE
Shobana Rajan, Astri M V Luoma, W Andrew Kofke
No abstract text is available yet for this article.
November 6, 2023: Journal of Neurosurgical Anesthesiology
https://read.qxmd.com/read/37919515/gastroenterology-fellowship-and-postdoctoral-training-in-omics-and-statistics-part-ii-how-can-it-be-achieved
#25
EDITORIAL
Madeline Alizadeh, Natalia Sampaio Moura, Alyssa Schledwitz, Seema A Patil, Jacques Ravel, Jean-Pierre Raufman
Data are being generated, collected, and aggregated in massive quantities at exponentially increasing rates. This "big data," discussed in depth in the first section of this two-part series, is increasingly important to understand the nuances of the gastrointestinal tract and its complex interactions and networks involving a host of other organ systems and microbes. Creating and using these datasets correctly requires comprehensive training; however, current instruction in the integration, analysis, and interpretation of big data appears to lag far behind data acquisition...
November 2, 2023: Digestive Diseases and Sciences
https://read.qxmd.com/read/37917927/using-academic-consultation-liaison-telepsychiatry-to-meet-the-mental-health-needs-of-complex-medically-ill-patients-in-underserved-areas-a-case-report
#26
JOURNAL ARTICLE
Zachary S Goodman, Spencer M Gardner, James K Rustad, Christine T Finn, H Samuel Landsman, Patrick A Ho
Background: The nationwide shortage of mental health resources often disproportionately affects rural areas. As innovative strategies are required to address mental health resource shortages in rural areas, telepsychiatry consultation (TPC) may represent a population health-oriented approach to bridge this gap. In this case report, we examine the use of TPC from an academic consultation-liaison psychiatry service to a rural community hospital. Case Report: We describe the case of a woman with Wernicke encephalopathy seeking to leave the hospital against medical advice and the role that the TPC service played in the patient's evaluation and management, including assessing decision-making capacity...
November 3, 2023: Telemedicine Journal and E-health
https://read.qxmd.com/read/37862113/is-geropsychology-forever-young-on-the-mother-continent-addressing-the-limited-research-on-psychology-of-aging-in-africa
#27
JOURNAL ARTICLE
John Bosco Chika Chukwuorji, Pauline Thuku, Nafisa Cassimjee, Kezia Mbuthia, Babatola D Olawa
OBJECTIVES: Our paper highlights areas of interest to psychologists studying aging in Africa and what has already been learned about aspects of psychological aging from studies done in the African context. We also considered whether there are issues that are unique about aging in the African context that might challenge how aging is typically considered in psychology research. METHOD: We reviewed articles recently published in major gerontology journals focusing on African older adults, with the goal of identifying key themes of current geropsychology in Africa...
October 20, 2023: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://read.qxmd.com/read/37856839/improving-patient-centered-care-for-hiv-and-mental-illness-exploring-hospital-and-community-integration-through-education
#28
JOURNAL ARTICLE
Deanna Chaukos, Sandalia Genus, Lesley Wiesenfeld, Robert Maunder, Maria Mylopoulos
Current models of care delivery are failing patients with complexity, like those living with HIV, mental illness and other psychosocial challenges. These patients often require resource-intensive personalized care across hospital and community settings, but available supports can be fragmented and challenging to access and navigate. To improve this, the authors created a program to enhance integrated, trauma-informed care through an innovative educational role for a HIV community caseworker embedded in an academic HIV Psychiatry clinic, called the Mental Health Clinical Fellowship...
October 19, 2023: AIDS Care
https://read.qxmd.com/read/37845142/-current-status-of-french-oculoplastics-in-france-and-in-europe
#29
JOURNAL ARTICLE
C Rocchi, A Martel
INTRODUCTION: In 2023, oculoplastics in France is experiencing a paradox with an imbalance between demand and supply of trainees. The goal of this study is to establish a factual overview of oculoplastics in France, with its limitations, and make proposals to optimize this sector. METHODS: An observational study was conducted by compiling epidemiological data related to oculoplastics. This included full-time hospital practitioners (HPs) in French university hospitals (FUH), data from the distributed computerized system for health assessment (SIDES), the specialized cross-disciplinary training (FST) in oculoplastics, the interuniversity diploma (DIU) in oculoplastics, the French University Ophthalmologists College (COUF), and the French Society of Reconstructive and Aesthetic Ophthalmology (SOPREF)...
December 2023: Journal Français D'ophtalmologie
https://read.qxmd.com/read/37788816/let-the-program-evaluation-committee-soar-applying-the-strengths-opportunities-aspirations-and-results-soar-framework-for-program-evaluation
#30
JOURNAL ARTICLE
Bharat Kumar, Alick Feng, Gatr-Alnada Gheriani, Ayesha Iftekhar, Ruoning Ni, Shadeh Ghaffari-Rafi, Svjetlana Dolovcak, Patricia Bruffey Thoene, Aaron Knaack, Melissa L Swee, Benjamin Davis, Manish Suneja
OBJECTIVE: Annual program evaluations are important activities of all graduate medical education programs. Although the Accreditation Council for Graduate Medical Education provides general guidelines, there is substantial scope for educational innovation. Strengths, opportunities, aspirations, and results (SOAR) is a strengths-based framework for strategic planning. Because SOAR emphasizes positivity and engagement, it is an appealing framework for evaluating graduate medical education programs...
October 2023: Southern Medical Journal
https://read.qxmd.com/read/37781721/virtual-reality-based-methods-for-training-novice-electrophysiology-trainees-a-pilot-study
#31
JOURNAL ARTICLE
Benjamin Gorbaty, Susana Arango, David Buyck, Ryan C James, Samantha T Porter, Paul Iaizzo, Tjörvi E Perry, Stephen Seslar
Developing an accurate and detailed 3-dimensional (3D) mental model of cardiac anatomy is critical for electrophysiology (EP) trainees. Due to its immersive nature, virtual reality (VR) may provide a better learning environment than traditional teaching methods for assimilating 3D cardiac anatomy. The purpose of this pilot study was to evaluate the technical feasibility of an interactive, remote VR-based method for teaching cardiac anatomy to novice EP trainees. We created a shared, remote VR environment that allows the shared viewing of high-resolution 3D cardiac models...
September 2023: Journal of Innovations in Cardiac Rhythm Management
https://read.qxmd.com/read/37744411/nurturing-next-generation-physicians-a-new-israeli-healthtech-fellowship
#32
Michal Rosen-Zvi, Motti Frimer, Aviv Shoher, Noah Liel-Cohen, Eli Sprecher, Miri Mizrahi Reuveni, Dan Shwarzman, Adva Tzuk Onn, Hedva Voliovitch
The Israeli Society for HealthTech aims at advancing the integration of innovation and healthcare entrepreneurship into medical practice and across traditional health professions, to benefit patients and improve quality of care. In 2021, the Society launched the first fellowship for board certified physicians in HealthTech. This backstory discusses the motivation of launching the program and reviews the design of the fellowship, including curriculum, the expertise of the lecturers, and initial tangible results of the program...
September 15, 2023: IScience
https://read.qxmd.com/read/37736467/examining-the-growing-demand-for-surgical-care-in-rural-communities-and-novel-approaches-to-achieving-a-sustainable-surgical-workforce-a-narrative-review
#33
REVIEW
Brittany A Long, Michael J Sweeney
Surgery continues to be an increasingly vital component of public health and aspect of patient care in rural communities. An anticipated shortage of surgeons within the next decade in the United States prompts a growing concern for increasing the delivery of essential surgical care to these populations. When considering the existing barriers to surgical healthcare in rural communities, there is a sense of urgency to identify innovative approaches that will promote a sustainable surgeon workforce. A narrative review was conducted to investigate the current state of access to essential surgical care in rural communities...
August 2023: Curēus
https://read.qxmd.com/read/37724836/reimagining-the-rheumatology-fellowship-interview-using-participatory-design-thinking-process-to-create-a-more-applicant-centered-experience
#34
JOURNAL ARTICLE
Bharat Kumar, Alick Feng, Gatr-Alnada Gheriani, Ayesha Iftekhar, Ruoning Ni, Mohamad Dimachkie, Gizem Gokalp, Izza Bazigh, Lindsay Moy, Chen Chao, Ankitha Lingamaneni, Axi Patel, Gretchen Santana Cepero, Tariq Iqtidar, Patricia Bruffey Thoene, Aaron Knaack, Melissa L Swee, Manish Suneja, Benjamin Davis
OBJECTIVE: Design thinking is a creative problem-solving process used to better understand users' needs and experiences so that a product or service can be improved. Its emphasis on empathy, iterative prototyping, and participatory collaboration make it an ideal methodology for innovation in medical education. We apply this framework to the virtual rheumatology fellowship interview process so that interviews can become more applicant centered. METHODS: This educational quality improvement project uses a design-thinking framework to identify opportunities and challenges for rheumatology fellowship applicants...
September 19, 2023: ACR open rheumatology
https://read.qxmd.com/read/37714796/integrated-dual-training-in-palliative-care-and-oncology
#35
JOURNAL ARTICLE
Kathryn DeCarli, Rachel Rodenbach, Ramy Sedhom, Jamie Von Roenn, Briana Ketterer
Fellowship training in Hospice and Palliative Medicine (HPM) and Hematology/Oncology (Hem/Onc) share common themes and roots in the holistic care of people living with cancer. As of 2021, approximately 630 physicians in the United States were board-certified in both HPM and Hem/Onc. There is increasing demand for an integrated fellowship pathway, and the inaugural integrated fellowship Match took place in 2022. We present the historical context of the overlap in HPM and Hem/Onc fellowship training, limitations of the standard training paradigm, and an overview of the recently developed integrated training pathway accredited by the Accreditation Council for Graduate Medical Education (ACGME)...
September 6, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37713654/association-between-ovarian-reserve-and-spontaneous-miscarriage-and-their-shared-genetic-architecture
#36
JOURNAL ARTICLE
Yan Yi, Jing Fu, Shi Xie, Qiong Zhang, Bin Xu, Yonggang Wang, Yijing Wang, Bin Li, Guihu Zhao, Jinchen Li, Yanping Li, Jing Zhao
STUDY QUESTION: Can potential mechanisms involved in the likely concurrence of diminished ovarian reserve (DOR) and miscarriage be identified using genetic data? SUMMARY ANSWER: Concurrence between ovarian reserve and spontaneous miscarriage was observed, and may be attributed to shared genetic risk loci enriched in antigen processing and presentation and autoimmune disease pathways. WHAT IS KNOWN ALREADY: Previous studies have shown that lower serum anti-Müllerian hormone (AMH) levels are associated with increased risk of embryo aneuploidy and spontaneous miscarriage, although findings have not been consistent across all studies...
November 2, 2023: Human Reproduction
https://read.qxmd.com/read/37697804/global-diversity-and-antimicrobial-resistance-of-typhoid-fever-pathogens-insights-from-a-meta-analysis-of-13-000-salmonella-typhi-genomes
#37
JOURNAL ARTICLE
Megan E Carey, Zoe A Dyson, Danielle J Ingle, Afreenish Amir, Mabel K Aworh, Marie Anne Chattaway, Ka Lip Chew, John A Crump, Nicholas A Feasey, Benjamin P Howden, Karen H Keddy, Mailis Maes, Christopher M Parry, Sandra Van Puyvelde, Hattie E Webb, Ayorinde Oluwatobiloba Afolayan, Anna P Alexander, Shalini Anandan, Jason R Andrews, Philip M Ashton, Buddha Basnyat, Ashish Bavdekar, Isaac I Bogoch, John D Clemens, Kesia Esther da Silva, Anuradha De, Joep de Ligt, Paula Lucia Diaz Guevara, Christiane Dolecek, Shanta Dutta, Marthie M Ehlers, Louise Francois Watkins, Denise O Garrett, Gauri Godbole, Melita A Gordon, Andrew R Greenhill, Chelsey Griffin, Madhu Gupta, Rene S Hendriksen, Robert S Heyderman, Yogesh Hooda, Juan Carlos Hormazabal, Odion O Ikhimiukor, Junaid Iqbal, Jobin John Jacob, Claire Jenkins, Dasaratha Ramaiah Jinka, Jacob John, Gagandeep Kang, Abdoulie Kanteh, Arti Kapil, Abhilasha Karkey, Samuel Kariuki, Robert A Kingsley, Roshine Mary Koshy, A C Lauer, Myron M Levine, Ravikumar Kadahalli Lingegowda, Stephen P Luby, Grant Austin Mackenzie, Tapfumanei Mashe, Chisomo Msefula, Ankur Mutreja, Geetha Nagaraj, Savitha Nagaraj, Satheesh Nair, Take K Naseri, Susana Nimarota-Brown, Elisabeth Njamkepo, Iruka N Okeke, Sulochana Putli Bai Perumal, Andrew J Pollard, Agila Kumari Pragasam, Firdausi Qadri, Farah N Qamar, Sadia Isfat Ara Rahman, Savitra Devi Rambocus, David A Rasko, Pallab Ray, Roy Robins-Browne, Temsunaro Rongsen-Chandola, Jean Pierre Rutanga, Samir K Saha, Senjuti Saha, Karnika Saigal, Mohammad Saiful Islam Sajib, Jessica C Seidman, Jivan Shakya, Varun Shamanna, Jayanthi Shastri, Rajeev Shrestha, Sonia Sia, Michael J Sikorski, Ashita Singh, Anthony M Smith, Kaitlin A Tagg, Dipesh Tamrakar, Arif Mohammed Tanmoy, Maria Thomas, Mathew S Thomas, Robert Thomsen, Nicholas R Thomson, Siaosi Tupua, Krista Vaidya, Mary Valcanis, Balaji Veeraraghavan, François-Xavier Weill, Jackie Wright, Gordon Dougan, Silvia Argimón, Jacqueline A Keane, David M Aanensen, Stephen Baker, Kathryn E Holt
BACKGROUND: The Global Typhoid Genomics Consortium was established to bring together the typhoid research community to aggregate and analyse Salmonella enterica serovar Typhi (Typhi) genomic data to inform public health action. This analysis, which marks 22 years since the publication of the first Typhi genome, represents the largest Typhi genome sequence collection to date (n=13,000). METHODS: This is a meta-analysis of global genotype and antimicrobial resistance (AMR) determinants extracted from previously sequenced genome data and analysed using consistent methods implemented in open analysis platforms GenoTyphi and Pathogenwatch...
September 12, 2023: ELife
https://read.qxmd.com/read/37691709/operation-diversify-plastic-surgery-an-innovative-strategy-to-increase-diversity-in-plastic-and-reconstructive-surgery
#38
JOURNAL ARTICLE
Mauricio A Downer, Dorian Hill, Chilando Mulenga, Ariel Vinson, Edgar Soto, Olatunde Bashorun, DeCoria McCauley, Kylar Wiltz, Ashley Newman, Paris D Butler
Healthcare disparities remain a significant problem facing the US healthcare system with recent evidence of persistent racial and ethnic disparities especially among patients from minority backgrounds. Recent studies have documented advantages to a racially and ethnically diverse surgical workforce such as higher patient satisfaction scores, superior patient compliance with physician recommendations, and increased participation in clinical research studies by minority patients. In plastic and reconstructive surgery (PRS), there is a noted deficit among residents and faculty that come from ethnically underrepresented in medicine (URiM) backgrounds despite recent efforts to increase diversity in PRS surgeons...
September 2023: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/37635922/creating-an-interdisciplinary-collaborative-network-of-scholars-in-child-maltreatment-prevention-a-network-analysis-of-the-doris-duke-fellowships-for-the-promotion-of-child-well-being
#39
JOURNAL ARTICLE
Colleen Schlecht, Elizabeth A McGuier, Lee Ann Huang, Deborah Daro
BACKGROUND: Child maltreatment is a complex problem requiring interdisciplinary collaborative research to generate innovative solutions. The Doris Duke Fellowships for the Promotion of Child Well-Being were designed to identify and nurture emerging scholars committed to child maltreatment prevention and create a supportive interdisciplinary learning network. OBJECTIVE: This paper examines connectivity within the collaborative network created by the fellowships program using longitudinal social network data...
October 2023: Children and Youth Services Review
https://read.qxmd.com/read/37609462/education-innovations-in-the-department-of-psychiatry-at-washington-university
#40
JOURNAL ARTICLE
Brendan O'Connor, Eric Spiegel, Melissa A Harbit, Nuri B Farber
The Department of Psychiatry at Washington University has been innovating psychiatric education during the second millennium at all levels of training - undergraduate medical, general residency, and child and adolescent psychiatry (CAP) fellowship training. Undergraduate medical education now occurs in three phases. The 18-month pre-clerkship phase is divided into seven multidisciplinary modules that span basic, social, and clinical sciences. Psychiatry is part of the seven-week long Brain and Behavior module...
2023: Missouri Medicine
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