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fever definition lancet

David L Heymann, Lincoln Chen, Keizo Takemi, David P Fidler, Jordan W Tappero, Mathew J Thomas, Thomas A Kenyon, Thomas R Frieden, Derek Yach, Sania Nishtar, Alex Kalache, Piero L Olliaro, Peter Horby, Els Torreele, Lawrence O Gostin, Margareth Ndomondo-Sigonda, Daniel Carpenter, Simon Rushton, Louis Lillywhite, Bhimsen Devkota, Khalid Koser, Rob Yates, Ranu S Dhillon, Ravi P Rannan-Eliya
The Ebola virus disease outbreak in West Africa was unprecedented in both its scale and impact. Out of this human calamity has come renewed attention to global health security--its definition, meaning, and the practical implications for programmes and policy. For example, how does a government begin to strengthen its core public health capacities, as demanded by the International Health Regulations? What counts as a global health security concern? In the context of the governance of global health, including WHO reform, it will be important to distil lessons learned from the Ebola outbreak...
May 9, 2015: Lancet
M P Mammen, A Lyons, B L Innis, W Sun, D McKinney, R C Y Chung, K H Eckels, R Putnak, N Kanesa-thasan, J M Scherer, J Statler, L V Asher, S J Thomas, D W Vaughn
Discordance between the measured levels of dengue virus neutralizing antibody and clinical outcomes in the first-ever efficacy study of a dengue tetravalent vaccine (Lancet, Nov 2012) suggests a need to re-evaluate the process of pre-screening dengue vaccine candidates to better predict clinical benefit prior to large-scale vaccine trials. In the absence of a reliable animal model and established correlates of protection for dengue, a human dengue virus challenge model may provide an approach to down-select vaccine candidates based on their ability to reduce risk of illness following dengue virus challenge...
March 14, 2014: Vaccine
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