keyword
MENU ▼
Read by QxMD icon Read
search

Cervical cancer metastatic

keyword
https://www.readbyqxmd.com/read/28315203/adc-histogram-analysis-of-cervical-cancer-aids-detecting-lymphatic-metastases-a-preliminary-study
#1
Stefan Schob, Hans Jonas Meyer, Nikolaos Pazaitis, Dominik Schramm, Kristina Bremicker, Marc Exner, Anne Kathrin Höhn, Nikita Garnov, Alexey Surov
PURPOSE: Apparent diffusion coefficient (ADC) histogram analysis has been used to some extent in cervical cancer (CC) to distinguish between low-grade and high-grade tumors. Although this differentiation is undoubtedly helpful, it would be even more crucial in the presurgical setting to determine whether a tumor already gained the potential to metastasize via the lymphatic system. So far, no studies investigated the potential of 3T ADC histogram analysis in CC to differentiate between nodal-positive and nodal-negative entities...
March 17, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28306621/prognostic-value-of-preoperative-18f-fdg-pet-ct-in-papillary-thyroid-cancer-patients-with-a-high-metastatic-lymph-node-ratio-a-multicenter-retrospective-cohort-study
#2
Seong Young Kwon, Eun Kyoung Choi, Eun Jung Kong, Ari Chong, Jung-Min Ha, Kyung Ah Chun, Ihn Ho Cho, Hee-Seung Bom, Jung-Joon Min, Jahae Kim, Ho-Chun Song, Joo Hyun O, Sung Hoon Kim
OBJECTIVE: Metastatic lymph node ratio (MLNR) is a known significant predictor of disease-free survival in differentiated thyroid cancer. The authors investigated the ability of preoperative fluorine-18 fluorodeoxyglucose (F-FDG) PET/CT to predict recurrence after surgery with radioactive iodine therapy considering MLNR. PATIENTS AND METHODS: A total of 274 patients who underwent preoperative PET/CT and surgery with radioactive iodine therapy were enrolled. The tumor-to-liver uptake ratio on PET/CT was calculated by dividing the maximum standardized uptake value of a primary lesion by the mean standardized uptake value of the normal liver...
March 16, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28295222/traf3-cyld-mutations-identify-a-distinct-subset-of-human-papilloma-virus-associated-head-and-neck-squamous-cell-carcinoma
#3
Michael Hajek, Andrew Sewell, Susan Kaech, Barbara Burtness, Wendell G Yarbrough, Natalia Issaeva
BACKGROUND: The incidence of human papillomavirus (HPV)-associated (HPV-positive) head and neck squamous cell carcinoma (HNSCC) of the oropharynx has dramatically increased over the last decade and continues to rise. Newly diagnosed HPV-positive HNSCCs in the United States currently outnumber any other HPV-associated cancers, including cervical cancer. Despite introduction of the HPV vaccine, the epidemic of HPV-positive HNSCC is expected to continue for approximately 60 years. Compared with patients who have tobacco-associated HNSCC, those who have HPV-positive HNSCC have better overall survival and response to treatment...
March 13, 2017: Cancer
https://www.readbyqxmd.com/read/28289664/significance-of-micrometastases-in-the-calculation-of-the-lymph-node-ratio-for-papillary-thyroid-cancer
#4
Young Woo Chang, Hwan Soo Kim, Seung Pil Jung, Hoon Yub Kim, Jae Bok Lee, Jeoung Won Bae, Gil Soo Son
PURPOSE: The lymph node ratio (LNR) is an important prognostic factor in papillary thyroid carcinoma (PTC), but micrometastases in cervical lymph nodes (LNs) are not of great clinical importance. In this study, we analyzed the accuracy of prediction of the prognosis depending on whether micrometastases were included in the number of metastatic LNs when calculating LNR. METHODS: The study included 353 PTC patients who underwent total thyroidectomy with neck LN dissection, and calculated LNR by 2 methods according to whether micrometastases were included in the number of metastatic LNs: Method 1 did not and method 2 did include...
March 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28283779/phase-ib-study-of-the-mitochondrial-inhibitor-me-344-plus-topotecan-in-patients-with-previously-treated-locally-advanced-or-metastatic-small-cell-lung-ovarian-and-cervical-cancers
#5
Jennifer R Diamond, Barbara Goff, Martin D Forster, Johanna C Bendell, Carolyn D Britten, Michael S Gordon, Hani Gabra, David M Waterhouse, Mark Poole, D Ross Camidge, Erika Hamilton, Kathleen M Moore
Background This multicenter, open-label, phase Ib study was designed to assess the safety, pharmacokinetics and preliminary efficacy of ME-344, a mitochondrial inhibitor, administered in combination with the topoisomerase I inhibitor, topotecan, in patients with previously treated, locally advanced or metastatic small cell lung (SCLC), ovarian and cervical cancers. Patients and methods In Part 1, patients received ME-344 10 mg/kg intravenously weekly on days 1, 8, 15 and 22 in combination with topotecan 4 mg/m(2) on days 1, 8, and 15 of a 28 day cycle...
March 10, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28277581/dietary-flavonoids-luteolin-and-quercetin-inhibit-invasion-of-cervical-cancer-by-reduction-of-ube2s-through-epithelial-mesenchymal-transition-signaling
#6
Tsung-Han Lin, Wen-Hsien Hsu, Pei-Hsun Tsai, Ying-Tang Huang, Cheng-Wei Lin, Ku-Chung Chen, Inn-Ho Tsai, Chithan C Kandaswami, Chang-Jen Huang, Geen-Dong Chang, Ming-Ting Lee, Chia-Hsiung Cheng
We previously reported that the dietary flavonoids, luteolin and quercetin, might inhibit the invasiveness of cervical cancer by reversing epithelial-mesenchymal transition (EMT) signaling. However, the regulatory mechanism exerted by luteolin and quercetin is still unclear. This study analyzed the invasiveness activation by ubiquitin E2S ligase (UBE2S) through EMT signaling and inhibition by luteolin and quercetin. We found that UBE2S expression was significantly higher in highly invasive A431 subgroup III (A431-III) than A431-parental (A431-P) cells...
March 9, 2017: Food & Function
https://www.readbyqxmd.com/read/28274154/investigational-drugs-for-the-treatment-of-cervical-cancer
#7
Fabio Barra, Domenica Lorusso, Umberto Leone Roberti Maggiore, Antonino Ditto, Giorgio Bogani, Francesco Raspagliesi, Simone Ferrero
Cervical cancer (CC) is currently the fourth most common malignant disease of women worldwide. Although the incidence and the mortality rates have been decreasing with screening detection and new treatment strategies, a significant number of metastatic or recurrent disease is still diagnosed. For those patients not amenable to curative treatments, such as surgery and radiation, palliative chemotherapy remains the standard of care. As chemotherapy regimens have limited activity, research is focalized on investigating novel pharmacologic strategies...
March 8, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28267911/-360-degrees-instrumentation-for-cervical-instability-due-to-metastatic-bone-disease-case-report
#8
J E Vargas-Jasso, M A Clara-Altamirano, G Reyes-Soto, M Cuéllar-Hubbe, J A Mejía-Pérez
INTRODUCTION: The spine is the most common site for bone metastases; being the breast, prostate and lung cancer which have most affected. The thoracic spine is involved in 70% of cases, followed by the lumbar and cervical region. MATERIAL AND METHODS: This is a 59 years old female diagnosed with breast adenocarcinoma and metastatic bone disease in cervical spine C2, C3 level and instability of that segment because of a compression fracture of C3 greater than 80% without invasion of the spinal canal, she begins with paresthesias of upper limbs...
July 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28262307/first-signs-of-late-presenting-cervical-lymph-node-metastasis-in-oral-cancers-during-follow-up
#9
J Sumino, N Uzawa, Y Ohyama, Y Michi, A Kawamata, M Mizutani, M Yamashiro
One of the most important prognostic factors in oral squamous cell carcinoma (OSCC) is the presence of lymph node metastasis. Therefore, the early detection of late-presenting cervical lymph node metastasis is important. Although many studies have assessed diagnostic modalities for detecting metastatic cervical lymph nodes, no study has evaluated the process, especially first signs, for detecting late-presenting cervical lymph node metastasis. A retrospective analysis comparing methods for detecting the first signs of late-presenting lymph node metastasis was performed...
March 2, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28261270/cooccurrence-of-metastatic-papillary-thyroid-carcinoma-and-salmonella-induced-neck-abscess-in-a-cervical-lymph-node
#10
Jae-Myung Kim, Ju-Yeon Kim, Eun Jung Jung, Eun Jin Song, Dong Chul Kim, Chi-Young Jeong, Young-Tae Ju, Young-Joon Lee, Soon-Chan Hong, Sang-Kyung Choi, Woo-Song Ha
Cervical lymph node metastasis is common in patients with papillary thyroid carcinoma (PTC). Salmonella species are rarely reported as causative agents in focal infections of the head and neck. The cooccurrence of lymph node metastasis from PTC and a bacterial infection is rare. This report describes a 76-year-old woman with a cervical lymph node metastasis from PTC and Salmonella infection of the same lymph node. The patient presented with painful swelling in her left lateral neck region for 15 days, and neck ultrasonography and computed tomography showed a cystic mass along left levels II-IV...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28255734/robot-assisted-laparoscopic-transperitoneal-infrarenal-lymphadenectomy-in-patients-with-locally-advanced-cervical-cancer-by-single-docking-do-we-need-a-backup-procedure
#11
Fatih Gucer, Selim Misirlioglu, Nuri Ceydeli, Cagatay Taskiran
To present our initial experience on the feasibility of robotic transperitoneal para-aortic lymphadenectomy up to left renal vein via single docking approach by high port insertion technique followed by left shoulder docking as a rescue backup procedure in surgically obstructed patients undergoing surgical staging because of locally advanced cervical cancer (LACC). Prospective observational preliminary study. Canadian Task Force classification II-3. Tertiary-care academic affiliated private hospital. Ten patients with LACC who underwent robotic transperitoneal infrarenal para-aortic lymphadenectomy between January 2012 and December 2014...
March 2, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28252836/central-compartment-management-in-patients-with-papillary-thyroid-cancer-presenting-with-metastatic-disease-to-the-lateral-neck-anatomic-pathways-of-lymphatic-spread
#12
Ilya Likhterov, Laura L Dos Reis, Mark L Urken
BACKGROUND: Papillary thyroid cancer (PTC) occasionally presents with metastases to the lateral neck, without clinically evident disease in the central neck. These cases may ultimately manifest as either skip metastases to the lateral compartment or as occult metastases in the central compartment. METHODS: This is a retrospective review of 80 patients with PTC with metastases to the lateral cervical lymph nodes treated from 2006 to 2015. Photographs of the cadaveric dissections were used with permission from the author...
March 2, 2017: Head & Neck
https://www.readbyqxmd.com/read/28250864/unusual-horner-s-syndrome-in-recurrent-breast-cancer-evaluation-using-18-f-fdg-pet-ct
#13
Sohyun Park, Tae Sung Kim, Seok-Ki Kim
(18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is a widely used imaging modality in the initial diagnosis of cancer, treatment response evaluation and detection of recurrence. Herein, we present the case of a 39-year-old female who presented right ptosis on the follow-up of breast cancer after surgery. Clinicians suspected Horner's syndrome, and the patient underwent FDG PET/CT for the evaluation of recurrence that could cause Horner's syndrome. FDG PET/CT demonstrated a focal hypermetabolic lesion in the right cervicothoracic junction area, corresponding to the preganglionic cervical sympathetic trunk...
March 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28249644/lymph-node-characteristics-for-predicting-locoregional-recurrence-of-papillary-thyroid-cancer-in-adolescents-and-young-adults
#14
Yungang Sun, Xiang Liu, Wei Ouyang, Huijuan Feng, Juqing Wu, Pan Chen, Jing Wang
PURPOSE: To determine lymph node (LN) characteristics predictive of locoregional recurrence (LRR) in adolescent and young adult (AYA) ages 15-39years presenting with papillary thyroid cancer (PTC) and cervical pathologically proven LN metastases (pN1). METHODS AND MATERIALS: Retrospective chart review was performed for all patients with PTC and nodal metastases who had undergone total thyroidectomy, LN dissection, and postoperative radioactive iodine therapy in a university hospital between 2006 and 2014...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28249642/preclinical-upar-targeted-multimodal-imaging-of-locoregional-oral-cancer
#15
M C Boonstra, P B A A Van Driel, S Keereweer, H A J M Prevoo, M A Stammes, V M Baart, C W G M Löwik, A P Mazar, C J H van de Velde, A L Vahrmeijer, C F M Sier
OBJECTIVES: Establishing adequate resection margins and lymphatic mapping are crucial for the prognosis of oral cancer patients. Novel targeted imaging modalities are needed, enabling pre- and intraoperative detection of tumour cells, in combination with improved post-surgical examination by the pathologist. The urokinase-receptor (uPAR) is overexpressed in head and neck cancer, where it is associated with tumour progression and metastasis. MATERIAL AND METHODS: To determine suitability of uPAR for molecular imaging of oral cancer surgery, human head and neck tumours were sectioned and stained for uPAR to evaluate the expression pattern compared to normal mucosa...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28245646/polyvalent-folate-dendrimer-coated-iron-oxide-theranostic-nanoparticles-for-simultaneous-magnetic-resonance-imaging-and-precise-cancer-cell-targeting
#16
Duy Luong, Samaresh Sau, Prashant Kesharwani, Arun K Iyer
The low therapeutic index of conventional chemotherapy along with poor prognosis of patients diagnosed with metastatic cancers are prompting clinicians to adopt newer strategies to simultaneously detect cancer-lesions at an early stage and to precisely deliver anticancer drugs to tumor sites. In this study, we employed a novel strategy to engineer a polyvalent theranostic nanocarrier consisting of super-paramagnetic iron oxide nanoparticle core (SPIONs) decorated with folic acid-polyamidoamine dendrimers surface (FA-PAMAM)...
February 28, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28244844/incidental-nodal-metastasis-of-differentiated-thyroid-carcinoma-in-neck-dissection-specimens-from-head-and-neck-cancer-patients
#17
R Lenzi, M Marchetti, L Muscatello
BACKGROUND: Occult differentiated thyroid carcinomas are not uncommon. The initial presentation of a thyroid carcinoma is often detection of a metastatic cervical lymph node. METHODS: A retrospective review was performed of the medical records of 304 patients who underwent neck dissection between 1996 and 2008 for squamous cell carcinoma of the head and neck. RESULTS: Ten patients (3.3 per cent) had nodal metastasis originating from papillary thyroid cancer...
April 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28241481/histone-h3-acetyl-k9-and-histone-h3-tri-methyl-k4-as-prognostic-markers-for-patients-with-cervical-cancer
#18
Susanne Beyer, Junyan Zhu, Doris Mayr, Christina Kuhn, Sandra Schulze, Simone Hofmann, Christian Dannecker, Udo Jeschke, Bernd P Kost
Chromatin remodeling alters gene expression in carcinoma tissue. Although cervical cancer is the fourth most common cancer in women worldwide, a systematic study about the prognostic value of specific changes in the chromatin structure, such as histone acetylation or histone methylation, is missing. In this study, the expression of histone H3 acetyl K9, which is known to denote active regions at enhancers and promoters, and histone H3 tri methyl K4, which preferentially identifies active gene promoters, were examined as both show high metastatic potential...
February 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28239257/percutaneous-vertebroplasty-relieves-pain-in-cervical-spine-metastases
#19
Li Bao, Pu Jia, Jinjun Li, Hao Chen, Yipeng Dong, Fei Feng, He Yang, Mengmeng Chen, Hai Tang
Percutaneous vertebroplasty (PVP) has been shown to release spinal pain and stabilize the vertebral body. PVP is suggested as an alternative treatment in spinal metastasis. Although cervical metastases is less prevalent than thoracic and lumbar spine, PVP procedure in cervical vertebrae remains technical challenging. We retrospectively analyzed the data from patients (n = 9) who underwent PVP using anterolateral approach to treat severe neck pain and restricted cervical mobility from metastatic disease. Patients were rated using modified Tokuhashi score and Tomita score before the procedure...
2017: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/28230778/caffeic-acid-expands-anti-tumor-effect-of-metformin-in-human-metastatic-cervical-carcinoma-htb-34-cells-implications-of-ampk-activation-and-impairment-of-fatty-acids-de-novo-biosynthesis
#20
Malgorzata Tyszka-Czochara, Pawel Konieczny, Marcin Majka
The efficacy of cancer treatments is often limited and associated with substantial toxicity. Appropriate combination of drug targeting specific mechanisms may regulate metabolism of tumor cells to reduce cancer cell growth and to improve survival. Therefore, we investigated the effects of anti-diabetic drug Metformin (Met) and a natural compound caffeic acid (trans-3,4-dihydroxycinnamic acid, CA) alone and in combination to treat an aggressive metastatic human cervical HTB-34 (ATCC CRL-1550) cancer cell line...
February 21, 2017: International Journal of Molecular Sciences
keyword
keyword
118693
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"