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Cervical cancer metastatic

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https://www.readbyqxmd.com/read/29775002/-clinical-significance-of-four-quadrant-localization-in-the-diagnosis-and-treatment-of-metastatic-carcinoma-of-the-neck-with-unknown-primary
#1
Y Y Gao, X H Chen
Objective: The aim of this study is to investigate the clinical significance of four quadrant localization in the diagnosis and treatment of unknown primary cervical metastases. Method: The clinical data with unknown primary cervical metastases, were analyzed retrospectively. All the patients have not been found the original site in the initial treatment. There are four quadrants in the neck, the neck line as the longitudinal axis, and edge of cricoid cartilage as the horizontal axis. When cervical metastasis occurred in the left and right upper quadrant, the primary tumor site and radiotherapy from the skull base to the root of the neck; when appear in left and right lower quadrant, the primary investigation site and radiotherapy from neck to thoracic mediastinum, left lower abdomen also includes following primary search...
June 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29774091/sensitive-molecular-detection-of-small-nodal-metastasis-in-uterine-cervical-cancer-using-hpv16-e6-ck19-muc1-cancer-biomarkers
#2
Vanessa Samouëlian, Nawel Mechtouf, Eric Leblanc, Guillaume B Cardin, Valérie Lhotellier, Denis Querleu, Françoise Révillion, Francis Rodier
Metastatic nodal involvement is a critical prognostic factor in uterine cervical cancer (UCC). To improve current methods of detecting UCC metastases in lymph nodes (LNs), we used quantitative PCR (qPCR) to assess mRNA expression of potential metastatic biomarkers. We found that expression of HPV16-E6, cytokeratin19 (CK19), and mucin1 (MUC1) is consistently upregulated in tumors and metastatic tissues, supporting a role for these genes in UCC progression. These putative biomarkers were able to predict the presence of histologically positive metastatic LNs with respective sensitivities and specificities of 82% and 99% (CK19), 76% and 95% (HPV16-E6), and 76% and 78% (MUC1)...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29772622/-delay-in-high-grade-metastatic-prostate-cancer-progression-by-dutasteride-a-case-report
#3
Yuya Yamada, Hiroshi Fujiwara, Shinya Somiya, Shohei Fujikawa, Yuki Kamiyama, Masahiro Tamaki, Toshio Kanaoka
An 84-year-old man was referred to our hospital with swollen right cervical lymph nodes. Computed tomography showed right supraclavicular and mediastinal lymph node enlargement, and fluorodeoxyglucose positronemissiontomography showed multiple areas of abnormally increased radioactivity inthe right supraclavicular and mediastinal lymph nodes, right ninth rib, and left fifth and seventh ribs. Biopsy of the right supraclavicular lymph node revealed metastatic adenocarcinoma with partial immunohistochemical staining for prostate specific antigen (PSA)...
April 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29757872/pattern-of-care-health-care-disparities-and-their-impact-on-survival-outcomes-in-stage-ivb-cervical-cancer-a-nationwide-retrospective-cohort-study
#4
Randa J Jalloul, Shelly Sharma, Celestine S Tung, Barrett OʼDonnell, Michelle Ludwig
OBJECTIVE: Although locally advanced cervical cancer can be cured, patients with stage IVB disease have poor prognosis with limited treatment options. Our aim was to describe the pattern of care and analyze health disparity variables that may account for differences in treatment modalities and survival in this population. METHODS: The National Cancer Database was queried for patients diagnosed between 2004 and 2013 with metastatic squamous cell carcinoma or adenocarcinoma of the cervix...
May 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29755799/spontaneous-regression-of-metastatic-papillary-thyroid-cancer-in-a-lymph-node
#5
Jien Shim, Jianyu Rao, Run Yu
Spontaneous regression of cancer is defined as disappearance of cancer in the absence of specific therapy. In thyroid cancer patients with biochemically incomplete response to initial treatments, spontaneous decline in thyroglobulin levels without any cancer treatment is a well-known phenomenon; however, spontaneous regression of persistent or recurrent structural disease has not been reported. We here present a case of papillary thyroid cancer in a 58-year-old female who underwent total thyroidectomy and two radioiodine ablations...
2018: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/29752277/the-highly-metastatic-nature-of-uterine-cervical-endometrial-cancer-displaying-tumor-related-leukocytosis-clinical-and-preclinical-investigations
#6
Tomoyuki Sasano, Seiji Mabuchi, Katsumi Kozasa, Hiromasa Kuroda, Mahiru Kawano, Ryoko Takahashi, Naoko Komura, Eriko Yokoi, Yuri Matsumoto, Kae Hashimoto, Kenjiro Sawada, Eiichi Morii, Tadashi Kimura
PURPOSE: The aim of this study was to investigate the metastatic potential of uterine cervical and endometrial cancer displaying tumor-related leukocytosis (TRL). EXPERIMENTAL DESIGN: Clinical data on uterine cervical (N=732) and endometrial cancer (N=900) were collected, and the metastatic potential of TRL-positive cancer was evaluated in univariate and multivariate analyses. Tumor and blood samples obtained from cervical cancer patients, cervical cancer cell lines, and a mouse model of cervical cancer were employed to examine the mechanisms underlying the highly metastatic nature of TRL-positive cancer, focusing on tumor-derived granulocyte-colony stimulating factor (G-CSF) and the myeloid-derived suppressor cells (MDSC)-mediated premetastatic niche...
May 11, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29738245/enzyme-responsive-charge-reversal-polymer-mediated-effective-gene-therapy-for-intraperitoneal-tumors
#7
Nasha Qiu, Jianqing Gao, Qi Liu, Jinqiang Wang, Youqing Shen
Gene therapy has demonstrated effectiveness in many genetic diseases as evidenced by recent clinical applications. Viral vectors have been extensively tested in clinical gene-therapy trials, but nonviral vectors such as cationic polymers or lipids are much less used due to their lower gene-transfection efficiencies. However, the advantages of nonviral vectors, such as easily tailored structures, nonimmunogenetics, and relatively low cost, still drive great efforts to improve their transfection efficiencies...
May 8, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29732436/the-c7-pedicle-as-a-superior-fixation-point-in-spinal-stabilization-for-spinal-metastatic-disease
#8
Harjot Thind, Andrew J Fabiano
Spinal metastatic disease (SMD) often requires spinal stabilization; however, the cervicothoracic junction can be a challenging area to instrument. An anterior approach may require division of the sternum. A posterior or posterolateral approach may rely on cervical lateral mass screws for superior construct fixation that are more prone to pullout than screws placed in a pedicle. The C7 pedicle is able to support pedicle screw fixation in most instances based on morphological features of the vertebra. When the C7 pedicle is used as a superior fixation point, it aligns with the thoracic pedicles below to create a streamlined posterior construct...
March 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29728868/curcumin-in-advancing-treatment-for-gynecological-cancers-with-developed-drug-and-radiotherapy-associated-resistance
#9
Amir Abbas Momtazi-Borojeni, Jafar Mosafer, Banafsheh Nikfar, Mahnaz Ekhlasi-Hundrieser, Shahla Chaichian, Abolfazl Mehdizadehkashi, Atefeh Vaezi
The development of resistance toward current cancer therapy modalities is an ongoing challenge in gynecological cancers, especially ovarian and cervical malignancies that require further investigations in the context of drug- and irradiation-induced resistance. In this regard, curcumin has demonstrated beneficial and highly pleiotropic actions and increased the therapeutic efficiency of radiochemotherapy. The antiproliferative, anti-metastatic, anti-angiogenic, and anti-inflammatory effects of curcumin have been extensively reported in the literature, and it could also act as a chemopreventive agent which mitigates the out-of-target harmful impact of chemotherapeutics on surrounding normal tissues...
May 5, 2018: Reviews of Physiology, Biochemistry and Pharmacology
https://www.readbyqxmd.com/read/29728273/the-european-society-of-gynaecological-oncology-european-society-for-radiotherapy-and-oncology-european-society-of-pathology-guidelines-for-the-management-of-patients-with-cervical-cancer
#10
David Cibula, Richard Pötter, François Planchamp, Elisabeth Avall-Lundqvist, Daniela Fischerova, Christine Haie Meder, Christhardt Köhler, Fabio Landoni, Sigurd Lax, Jacob Christian Lindegaard, Umesh Mahantshetty, Patrice Mathevet, W Glenn McCluggage, Mary McCormack, Raj Naik, Remi Nout, Sandro Pignata, Jordi Ponce, Denis Querleu, Francesco Raspagliesi, Alexandros Rodolakis, Karl Tamussino, Pauline Wimberger, Maria Rosaria Raspollini
BACKGROUND: Despite significant advances in the screening, detection, and treatment of preinvasive cervical lesions, invasive cervical cancer is the fifth most common cancer in European women. There are large disparities in Europe and worldwide in the incidence, management, and mortality of cervical cancer. OBJECTIVE: The European Society of Gynaecological Oncology (ESGO), the European Society for Radiotherapy and Oncology (ESTRO), and the European Society of Pathology (ESP) jointly develop clinically relevant and evidence-based guidelines in order to improve the quality of care for women with cervical cancer across Europe and worldwide...
April 12, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29725757/the-european-society-of-gynaecological-oncology-european-society-for-radiotherapy-and-oncology-european-society-of-pathology-guidelines-for-the-management-of-patients-with-cervical-cancer
#11
David Cibula, Richard Pötter, François Planchamp, Elisabeth Avall-Lundqvist, Daniela Fischerova, Christine Haie-Meder, Christhardt Köhler, Fabio Landoni, Sigurd Lax, Jacob Christian Lindegaard, Umesh Mahantshetty, Patrice Mathevet, W Glenn McCluggage, Mary McCormack, Raj Naik, Remi Nout, Sandro Pignata, Jordi Ponce, Denis Querleu, Francesco Raspagliesi, Alexandros Rodolakis, Karl Tamussino, Pauline Wimberger, Maria Rosaria Raspollini
BACKGROUND: Despite significant advances in the screening, detection, and treatment of preinvasive cervical lesions, invasive cervical cancer is the fifth most common cancer in European women. There are large disparities in Europe and worldwide in the incidence, management, and mortality of cervical cancer. OBJECTIVE: The European Society of Gynecological Oncology (ESGO), the European Society for Radiotherapy and Oncology (ESTRO), and the European Society of Pathology (ESP) jointly develop clinically relevant and evidence-based guidelines in order to improve the quality of care for women with cervical cancer across Europe and worldwide...
May 4, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29721161/findings-of-multiple-hpv-genotypes-in-cervical-carcinoma-are-associated-with-poor-cancer-specific-survival-in-a-swedish-cohort-of-cervical-cancer-primarily-treated-with-radiotherapy
#12
Malin Kaliff, Bengt Sorbe, Louise Bohr Mordhorst, Gisela Helenius, Mats G Karlsson, Gabriella Lillsunde-Larsson
Cervical cancer (CC) is one of the most common cancers in women and virtually all cases of CC are a result of a persistent infection of human papillomavirus (HPV). For disease detected in early stages there is curing treatment but when diagnosed late with recurring disease and metastasis there are limited possibilities. Here we evaluate HPV impact on treatment resistance and metastatic disease progression. Prevalence and distribution of HPV genotypes and HPV16 variants in a Swedish CC patient cohort (n=209) was evaluated, as well as HPV influence on patient prognosis...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29718274/clinical-usefulness-of-2-deoxy-2-18f-fluoro-d-glucose-positron-emission-tomography-computed-tomography-for-assessing-early-oral-squamous-cell-carcinoma-ct1-2n0m0
#13
Emi Yamaga, Akira Toriihara, Shin Nakamura, Sakurako Asai, Tomoyuki Fujioka, Ryoichi Yoshimura, Yasuyuki Michi, Hiroyuki Harada, Ukihide Tateishi
Background: Positron emission tomography with 2-deoxy-2-[18F] fluoro-d-glucose integrated with computed tomography (FDG-PET/CT) is a useful method to evaluate patients with oral squamous cell carcinoma (OSCC). However, the prognostic significance of FDG-PET/CT for assessing early OSCC remains unclear. Methods: Pretreatment FDG-PET/CT of 205 consecutive patients (125 men, 80 women, mean age 59.7 year old) with early OSCC (cT1-2N0M0) between June 2010 and December 2014 were retrospectively analyzed...
April 28, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29715097/demethoxycurcumin-suppresses-migration-and-invasion-of-human-cervical-cancer-hela-cells-via-inhibition-of-nf-%C3%AE%C2%BAb-pathways
#14
Chin-Chung Lin, Chao-Lin Kuo, Yi-Ping Huang, Cheng-Yen Chen, Ming-Jie Hsu, Yung Lin Chu, Fu-Shin Chueh, Jing-Gung Chung
BACKGROUND/AIM: Demethoxycurcumin (DMC), one of the curcuminoids present in turmeric, has been shown to induce cell death in many human cancer cell lines, however, there has not been any investigation on whether DMC inhibits metastatic activity in human cervical cancer cells in vitro. In the present study, DMC at 2.5-15 μM decreased cell number, thus, we used IC20 (7.5 μM) for further investigation of its anti-metastatic activity in human cervical cancer HeLa cells. MATERIALS AND METHODS: The wound healing, migration, invasion, zymography, and western blotting assays were used to investigate the effects of DMC on HeLa cells...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29712601/central-lymph-node-dissection-improves-lymph-node-clearance-in-papillary-thyroid-cancer-patients-with-lateral-neck-metastases-even-after-prior-total-thyroidectomy
#15
Chad M Hall, Samuel K Snyder, Terry C Lairmore
The oncologic benefit of a central lymph node dissection (CLND) at the time of modified radical neck dissection (MRND) in patients with papillary thyroid cancer who have previously undergone a total thyroidectomy (TT) has not been studied. Patients with lateral cervical metastases were divided into two treatment groups: the concurrent cohort (TT with CLND and MRND), and the interval cohort (CLND and MRND after prior TT). Primary outcomes were lymph node metastases, skip metastases, level VI cancer recurrence, hypoparathyroidism and recurrent laryngeal nerve injury...
April 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29706467/hpv-molecular-pathways-and-targets
#16
REVIEW
Shilpi Gupta, Prabhat Kumar, Bhudev C Das
Infection of high-risk human papillomaviruses (HPVs) is a prerequisite for the development of cervical carcinoma. HPV infections are also implicated in the development of other types of carcinomas. Chronic or persistent infection of HPV is essential but HPV alone is inadequate, additional endogenous or exogenous cues are needed along with HPV to induce cervical carcinogenesis. The strategies that high-risk HPVs have developed in differentiating epithelial cells to reach a DNA-synthesis competent state leading to tumorigenic transformation are basically due to overexpression of the E6 and E7 oncoproteins and the activation of diverse cellular regulatory or signaling pathways that are targeted by them...
April 5, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29705969/the-impact-of-complete-embedding-of-remaining-tissue-in-gynecological-lymph-node-dissection-specimen-in-surgical-pathology-on-lymph-node-yield-is-it-clinically-relevant
#17
Julia Andruszkow, Ivo Meinhold-Heerlein, Brigitte Winkler, Benjamin Bruno, Ruth Knüchel, Jörg Jäkel
The assessment of nodal metastases in gynecological surgical specimen is an important staging parameter, directing further therapeutic procedures. Since the number of lymph nodes (LNs) removed is seen as an indicator of surgical and pathological quality, the demand for higher lymph node (LN) counts is raising. The goal of this prospective study was the comparison between lymph node counts of macroscopically detectable LNs and the LN yield by complete embedding and proceeding of all submitted LN-containing tissue in the pathology laboratory...
April 28, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29688967/the-european-society-of-gynaecological-oncology-european-society-for-radiotherapy-and-oncology-european-society-of-pathology-guidelines-for-the-management-of-patients-with-cervical-cancer
#18
David Cibula, Richard Pötter, François Planchamp, Elisabeth Avall-Lundqvist, Daniela Fischerova, Christine Haie Meder, Christhardt Köhler, Fabio Landoni, Sigurd Lax, Jacob Christian Lindegaard, Umesh Mahantshetty, Patrice Mathevet, W Glenn McCluggage, Mary McCormack, Raj Naik, Remi Nout, Sandro Pignata, Jordi Ponce, Denis Querleu, Francesco Raspagliesi, Alexandros Rodolakis, Karl Tamussino, Pauline Wimberger, Maria Rosaria Raspollini
BACKGROUND: Despite significant advances in the screening, detection, and treatment of preinvasive cervical lesions, invasive cervical cancer is the fifth most common cancer in European women. There are large disparities in Europe and worldwide in the incidence, management, and mortality of cervical cancer. OBJECTIVE: The European Society of Gynaecological Oncology (ESGO), the European Society for Radiotherapy and Oncology (ESTRO), and the European Society of Pathology (ESP) jointly develop clinically relevant and evidence-based guidelines in order to improve the quality of care for women with cervical cancer across Europe and worldwide...
May 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29683929/18f-fdg-pet-ct-in-the-evaluation-of-cancer-cervix-where-do-we-stand-today
#19
Shanmuga S Palaniswamy, Chaitanya R Borde, Padma Subramanyam
The incidence of gynecological malignancies is on the rise partly because of the availability of screening programmes, awareness, higher technological advancements, and availability of better medical care. Early diagnosis of any malignancy leads to prompt treatment. Use of 18Fluorine-Fluorodeoxyglucose (F-FDG) PET/CT in the treatment and follow-up of patients with Ca cervix considerably improves patient management. The primary diagnosis of Ca cervix is made either by biopsy of a visible tumor on the cervix or by a cone biopsy of a nonvisible malignant cervical focus...
April 20, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29671552/cervical-cancer-evaluation-and-management
#20
Jennifer Wipperman, Tara Neil, Tracy Williams
Human papillomavirus infection is the precursor for the development of cervical cancer and is detectable in 99.7% of squamous cell carcinoma and adenocarcinoma cases. Early detection of precancerous lesions with Papanicolaou testing remains the primary mechanism for cancer prevention. Once cervical cancer is diagnosed, treatment may involve surgery, radiation therapy, chemotherapy, or a combination. The choice of therapy depends on the stage of disease, lymph node involvement, patient comorbidities, and risk factors for recurrence...
April 1, 2018: American Family Physician
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