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Cervical cancer metastatic

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https://www.readbyqxmd.com/read/29337896/caffeic-acid-and-metformin-inhibit-invasive-phenotype-induced-by-tgf-%C3%AE-1-in-c-4i-and-htb-35-siha-human-cervical-squamous-carcinoma-cells-by-acting-on-different-molecular-targets
#1
Malgorzata Tyszka-Czochara, Malgorzata Lasota, Marcin Majka
During the progression of epithelial cancer, the cells may lose epithelial markers and gain mesenchymal phenotype via Epithelial-Mesenchymal Transition (EMT). Such transformation of epithelial cancer cells to mesenchymal-like characteristic benefits plasticity and supports their ability to migrate. The aim of this study was to evaluate the influence of natural compound Caffeic Acid (CA) alone and in combination with antidiabetic drug Metformin (Met) on metastatic progression of two human cervical squamous cell cancer lines, C-4I and HTB-35/SiHa cells...
January 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29332349/characteristics-and-clinical-significance-of-recurrent-laryngeal-nerve-lymph-node-metastasis-in-esophageal-squamous-cell-carcinoma
#2
Longfei Ma, Jiaqing Xiang, Yawei Zhang, Hong Hu, Rongrong Shao, Dong Lin
PURPOSE: The recurrent laryngeal nerve lymph nodes (RLN LNs) are among the most common metastatic sites in esophageal cancer, and the dissection of these lymph nodes (LNs) is considered beneficial. The purpose of this study was to evaluate the characteristics of RLN LN metastases from esophageal squamous cell carcinoma, and the effects of these metastases on the prognosis of patients. In addition, we aimed to determine the reasonable range of dissection of regional LNs. METHODS: The clinical data from 348 patients who underwent resection for esophageal carcinoma were retrospectively analyzed...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29324916/a-comparison-of-18f-fdg-pet-ct-findings-in-hiv-positive-compared-to-hiv-negative-patients-with-recurrent-cervical-cancer
#3
Kehinde Ololade, Neo P Mokgoro, Ismaheel O Lawal, Mariza Vorster, Tebatso G Boshomane, Mike M Sathekge
OBJECTIVE: HIV-positive women with cervical cancer have higher recurrence and death rates with shorter time to recurrence and death compared with HIV-negative subjects. The objective of this study was to compare the recurrence patterns in HIV-positive women with invasive cervical cancer to their HIV-negative counterparts using 18F-FDG PET/CT. SUBJECTS AND METHODS: We evaluated 40 HIV- seropositive and 79 HIV-seronegative patients with recurrent cervical carcinoma using 18F-FDG PET/CT...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29302493/locally-advanced-asymptomatic-papillary-thyroid-cancer-presenting-with-retropharyngeal-lymph-node-metastasis-symptoms
#4
Roostam Kholmatov, Obinwanne Emejulu, Fadi Murad, Rizwan Aslam, Emad Kandil
Papillary thyroid cancer (PTC) rarely metastasizes to the retropharyngeal lymph nodes. Managing patients with locally advanced primary PTC and metastasis located in distant anatomical areas is challenging. Herein, we report a 56-year-old patient with locally advanced asymptomatic PTC, who presented with obstructive airway symptoms due to the metastatic retropharyngeal lymph node. The patient underwent simultaneous total thyroidectomy, central lymph node dissection, en bloc resection of strap muscle and left laryngeal nerve via cervical approach and transoral resection of the metastatic retropharyngeal lymph node...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29284539/prognostic-values-of-the-integrated-model-incorporating-the-volume-of-metastatic-regional-cervical-lymph-node-and-pretreatment-serum-epstein-barr-virus-dna-copy-number-in-predicting-distant-metastasis-in-patients-with-n1-nasopharyngeal-carcinoma
#5
Ji-Jin Yao, Guan-Qun Zhou, Ya-Qin Wang, Si-Yang Wang, Wang-Jian Zhang, Ya-Nan Jin, Fan Zhang, Li Li, Li-Zhi Liu, Zhi-Bin Cheng, Jun Ma, Zhen-Yu Qi, Ying Sun
BACKGROUND: According to the 7th edition of the American Joint Committee on Cancer (AJCC) staging system, over 50% of patients with nasopharyngeal carcinoma (NPC) have N1 disease at initial diagnosis. However, patients with N1 NPC are relatively under-researched, and the metastasis risk of this group is not well-stratified. This study aimed to evaluate the prognostic values of gross tumor volume of metastatic regional lymph node (GTVnd) and pretreatment serum copy number of Epstein-Barr virus (EBV) DNA in predicting distant metastasis of patients with N1 NPC, and to develop an integrated prognostic model that incorporates GTVnd and EBV DNA copy number for this group of patients...
December 29, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29282522/the-incidence-of-malignancy-in-clinically-benign-cystic-lesions-of-the-lateral-neck-our-experience-and-proposed-diagnostic-algorithm
#6
Moshe Yehuda, Melissa E Schechter, Nora Abu-Ghanem, Gilad Golan, Gilad Horowitz, Dan M Fliss, Sara Abu-Ghanem
AIM: Solitary cystic masses of the lateral neck in an adult patient can pose a diagnostic dilemma. Malignancy must be ruled out since metastases arising from H&N cancers may mimic the presentation of benign cystic masses. Only a small number of studies have investigated the diagnostic management and malignancy rate of clinically benign solitary cervical cystic lesions. There are no established guidelines for the diagnostic evaluation. METHODS: Retrospective review of the clinical, cytological, radiological, and pathological records of all adult patients (> 18 years) operated on for second branchial cleft cysts (BrCC) between 1/2008-2010/2016...
December 27, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29245271/metastatic-esophageal-cancer-presenting-as-shock-by-injury-of-vagus-nerve-mimicking-baroreceptor-reflex-a-case-report
#7
Kenji Tsuchihashi, Tomoyasu Yoshihiro, Tomomi Aikawa, Kenta Nio, Kotoe Takayoshi, Taku Yokoyama, Mitsuhiro Fukata, Shuji Arita, Hiroshi Ariyama, Yukiko Shimizu, Yuichiro Yoshida, Takehiro Torisu, Motohiro Esaki, Keita Odashiro, Hitoshi Kusaba, Koichi Akashi, Eishi Baba
RATIONALE: Neurogenic shock is generally typified by spinal injury due to bone metastases in cancer patients, but continuous disturbance of the vagus nerve controlling the aortic arch baroreceptor can cause shock by a reflex response through the medulla oblongata. PATIENT CONCERNS: A 43-year-old woman with dysphagia presented to our hospital. Computed tomography showed a primary tumor adjacent to and surrounding half the circumference of the descending aorta, and multiple cervical lymph node metastases, including a 55 × 35-mm lymph node overlapping the root of the left vagus nerve...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29242498/microrna-221-3p-a-twist2-target-promotes-cervical-cancer-metastasis-by-directly-targeting-thbs2
#8
Wen-Fei Wei, Chen-Fei Zhou, Xiang-Guang Wu, Li-Na He, Lan-Fang Wu, Xiao-Jing Chen, Rui-Ming Yan, Mei Zhong, Yan-Hong Yu, Li Liang, Wei Wang
MicroRNAs have implicated in the relapse and metastasis of cervical cancer, which is the leading cause of cervical cancer-related mortality. However, the underlying molecular mechanisms need further elucidation. Our present study revealed that miR-221-3p is transcriptionally promoted in metastatic cervical cancer tissues compared with non-metastatic cervical cancer tissues. Forced overexpression of miR-221-3p facilitated EMT and promoted cell migration and invasion in vitro and lymphatic metastasis in vivo...
December 14, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29234622/impact-of-serum-tsh-and-anti-thyroglobulin-antibody-levels-on-lymph-node-fine-needle-aspiration-thyroglobulin-measurements-in-differentiated-thyroid-cancer-patients
#9
Marta Amaro da Silveira Duval, André Borsatto Zanella, Ana Patrícia Cristo, Carlo Sasso Faccin, Marcia Silva Graudenz, Ana Luiza Maia
Background: Thyroglobulin measurements in the washout of fine needle aspiration (FNA-Tg) are an excellent tool to detect lymph node (LN) metastases of differentiated thyroid carcinoma (DTC). Nevertheless, how to define the best cutoffs and the influence of potential confounders are still being discussed. Objective: To evaluate the accuracy of FNA-Tg measurement to detect DTC metastases and the influence of thyroid status and anti-thyroglobulin antibodies (TgAb)...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29229603/lnmicc-promotes-nodal-metastasis-of-cervical-cancer-by-reprogramming-fatty-acid-metabolism
#10
Chunliang Shang, Wei Wang, Yuandong Liao, Yili Chen, Tianyu Liu, Qiqiao Du, Jiaming Huang, Yanchun Liang, Junxiu Liu, Yunhe Zhao, Luyan Guo, Zheng Hu, Shuzhong Yao
Cancer spread to lymph nodes (LN) predicts poor survival but underlying mechanisms remain little understood. In this study, we show that overexpression of the long non-coding RNA LNMICC associates with LN metastasis of primary cervical cancer, where it serves as an independent high-risk factor in patient survival. Functional investigations demonstrated that LNMICC promoted LN metastasis by reprogramming fatty acid metabolism, by recruiting the nuclear factor NPM1 to the promoter of the fatty acid binding protein FABP5...
December 11, 2017: Cancer Research
https://www.readbyqxmd.com/read/29222647/bevacizumab-for-recurrent-persistent-or-advanced-cervical-cancer-reproducibility-of-gog-240-study-results-in-real-world-patients
#11
A Godoy-Ortiz, Y Plata, J Alcaide, A Galeote, B Pajares, E Saez, E Alba, A Sánchez-Muñoz
PURPOSE: Bevacizumab is the only therapeutic target approved for patients with persistent, recurrent or advanced cervical cancer from a phase III study that combined with chemotherapy; it proves a significant increase in overall survival. To retrospectively assess the efficacy and safety of bevacizumab as the first-line treatment in patients from usual clinical practice with recurrent/persistent or advanced cervical cancer. PATIENTS AND METHODS: Treatment consisted of cisplatin 50 mg/m2 or carboplatin AUC 5 plus paclitaxel 175 mg/m2 for 6-8 cycles and bevacizumab 15 mg/kg every 3 weeks up to progression or unacceptable toxicity...
December 8, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29203116/diagnosis-and-management-of-metastatic-neoplasms-with-unknown-primary
#12
REVIEW
Tilmann Bochtler, Harald Löffler, Alwin Krämer
In cancer of unknown primary (CUP), metastases are clinically and histologically confirmed, but the primary tumor site remains elusive after extensive work-up. CUPs make up for 2-3% of all epithelial malignancies. The two prevailing histologies are adenocarcinomas and undifferentiated carcinomas, whereas squamous cell carcinomas, neuroendocrine carcinomas and rare histologies account for the remaining 10%. The diagnostic work-up in CUP relies strongly on a detailed immunohistological (IHC) analysis in order to characterize the tumor type, nowadays aided by molecular techniques...
November 26, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29185901/identification-of-distant-metastatic-disease-in-uterine-cervical-and-endometrial-cancers-with-fdg-pet-ct-analysis-from-the-acrin-6671-gog-0233-multicenter-trial
#13
Michael S Gee, Mostafa Atri, Andriy I Bandos, Robert S Mannel, Michael A Gold, Susanna I Lee
Purpose To assess the accuracy of staging positron emission tomography (PET)/computed tomography (CT) in detecting distant metastasis in patients with local-regionally advanced cervical and high-risk endometrial cancer in the clinical trial by the American College of Radiology Imaging Network (ACRIN) and the Gynecology Oncology Group (GOG) (ACRIN 6671/GOG 0233) and to compare central and institutional reader performance. Materials and Methods In this prospective multicenter trial, PET/CT and clinical data were reviewed for patients enrolled in ACRIN 6671/GOG 0233...
November 29, 2017: Radiology
https://www.readbyqxmd.com/read/29182608/impact-of-tumour-histology-on-survival-in-advanced-cervical-carcinoma-an-nrg-oncology-gynaecologic-oncology-group-study
#14
Leigh G Seamon, James J Java, Bradley J Monk, Richard T Penson, Jubilee Brown, Robert S Mannel, Anna Oaknin, Mario M Leitao, Eric L Eisenhauer, Harry J Long, Shu Y Liao, Krishnansu S Tewari
BACKGROUND: Based primarily on studies concerning early-stage tumours (treated surgically), and locally advanced disease (treated with chemoradiation), the prognosis for women with adenocarcinoma (AC) or adenosquamous (AS) carcinoma has been reported to be poorer than those with squamous cell carcinoma (SCCA) of the cervix. It is unclear whether differences in prognosis also persist in the setting of recurrent or metastatic disease treated using chemotherapy doublets with or without bevacizumab...
November 28, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29179646/practical-initial-risk-stratification-based-on-lymph-node-metastases-in-pediatric-and-adolescent-differentiated-thyroid-cancer
#15
MinJi Jeon, Young Nam Kim, Tae-Yon Sung, Suck Joon Hong, Yoon Young Cho, Tae Yong Kim, YoungKee Shong, Won Bae Kim, Sun Wook Kim, Jae Hoon Chung, Tae Hyuk Kim, Won Gu Kim
BACKGROUND: Data on the risk stratification of pediatric differentiated thyroid cancer (DTC) remain scarce. We aimed to evaluate the predictors of structural persistent/recurrent disease and revise an initial risk stratification system in pediatric DTC patients. METHODS: This retrospective cohort study included 203 patients (< 20 years) from two tertiary referral centers in Korea. We classified the extent of cervical lymph node (LN) metastasis based on the location or number of metastatic LNs...
November 27, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29170170/twist-on-a-classic-vitamin-d-and-hypercalcaemia-of-malignancy
#16
Juan C Osorio, Masha G Jones, Nina Schatz-Siemers, Stephanie J Tang
Malignancy is the most common cause of hypercalcaemia in the inpatient setting. Most cases are caused by tumour production of parathyroid hormone-related protein and osseous metastases. In less than 1% of cases, hypercalcaemia is driven by increased production of 1,25-dihydroxyvitamin D (1,25(OH)2D), a mechanism most commonly seen in haematological malignancies. Here, we describe a woman with metastatic small cell cervical carcinoma who developed hypercalcaemia secondary to paraneoplastic overproduction of 1,25(OH)2D, a finding that, to our knowledge, has not been previously associated with this cancer...
November 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29166807/secondary-malignancies-of-the-bladder-avoiding-the-diagnostic-pitfall
#17
Alexander Feldman, Samuel Borak, Soroush Rais-Bahrami, Jennifer Gordetsky
Although rare, secondary tumors of the bladder can present a diagnostic dilemma to pathologists considering a differential diagnosis of primary bladder cancer. We investigated the clinicopathologic and imaging characteristics of metastatic tumors to the bladder. We retrospectively reviewed the surgical pathology databases from 2 sites from 2013 to 2016, identifying 66 cases of secondary bladder tumors. Clinical, pathologic, and imaging findings were reviewed. Mean age at diagnosis was 63 years (range = 25-87)...
November 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29164573/role-of-perfusion-ct-in-the-evaluation-of-metastatic-nodal-tumor-response-after-radiochemotherapy-in-head-and-neck-cancer-preliminary-findings
#18
S Ursino, L Faggioni, F Fiorica, D Delishaj, V Seccia, F Pasqualetti, I Desideri, C Colosimo, R Morganti, F Paiar, D Caramella
OBJECTIVE: To assess changes of CT perfusion parameters (ΔPCTp) of cervical lymph node metastases from head and neck cancer (HNC) before and after radiochemotherapy (RT-CT) and their association with nodal tumor persistence. PATIENTS AND METHODS: Eligibility criteria included HNC (Stage III-IV) candidates for RT-CT. Patients underwent perfusion CT (PCT) at baseline 3 weeks and 3 months after RT-CT. Blood volume (BV), blood flow (BF), mean transit time (MTT) and permeability surface (PS) were calculated...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164299/comparison-of-18-f-fdg-pet-mri-and-mri-alone-for-whole-body-staging-and-potential-impact-on-therapeutic-management-of-women-with-suspected-recurrent-pelvic-cancer-a-follow-up-study
#19
Lino M Sawicki, Julian Kirchner, Johannes Grueneisen, Verena Ruhlmann, Bahriye Aktas, Benedikt M Schaarschmidt, Michael Forsting, Ken Herrmann, Gerald Antoch, Lale Umutlu
PURPOSE: To evaluate the diagnostic performance of (18)F-FDG PET/MRI for whole-body staging and potential changes in therapeutic management of women with suspected recurrent pelvic cancer in comparison with MRI alone. METHODS: Seventy-one consecutive women (54 ± 13 years, range: 25-80 years) with suspected recurrence of cervical (32), ovarian (26), endometrial (7), vulvar (4), and vaginal (2) cancer underwent PET/MRI including a diagnostic contrast-enhanced MRI protocol...
November 21, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29161240/rapid-nodal-staging-of-head-and-neck-cancer-surgical-specimens-with-flow-cytometric-analysis
#20
Valtteri Häyry, Åsa Kågedal, Eric Hjalmarsson, Pedro Farrajota Neves da Silva, Cecilia Drakskog, Gregori Margolin, Susanna Kumlien Georén, Eva Munck-Wikland, Ola Winqvist, Lars Olaf Cardell
BACKGROUND: Detection of metastatic spread of head and neck cancer to cervical lymph nodes is essential for optimal design of therapy. Undetected metastases lead to mortality, which can be prevented by better detection methods. METHODS: We analysed 41 lymph nodes from 19 patients with oral squamous cell carcinoma (OSCC). Each lymph node was divided in two, one half processed for histopathology and the other half dissociated into single-cell suspension, stained for the carcinoma cell markers cytokeratin 5/8 (CK5/8), epithelial cell adhesion molecule (EpCAM) and epithelial mucin (MUC-1), and analysed with flow cytometry...
November 21, 2017: British Journal of Cancer
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