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https://www.readbyqxmd.com/read/29792759/hematologic-parameters-and-viral-status-for-zika-chikungunya-bluetongue-and-epizootic-hemorrhagic-disease-in-white-tailed-deer-odocoileus-virginianus-on-st-john-us-virgin-islands
#1
Jon D Reuter, Suzanne L Nelson
A population of white-tailed deer ( Odocoileus virginianus) resides throughout the island of St John, US Virgin Islands, predominately in the Virgin Islands National Park. Adult deer ( n=23), ranging from 1 yr to 8 yr old, were assessed to characterize body condition and health. Serologic samples were screened for important viral pathogens in the area, including Zika, chikungunya, bluetongue, and epizootic hemorrhagic disease viruses. Samples were collected in July 2016; males were in velvet and all females were in diestrus...
May 24, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29792154/exploration-of-hetero-aryl-derived-thienylchalcones-for-antiviral-and-anticancer-activities
#2
Vikrant Patil, Siddappa A Patil, Renukadevi Patil, Alejandro Bugarin, Kenneth Beaman, Shivaputra A Patil
BACKGROUND: Search for new antiviral and anticancer agents are essential because of the emergence of drug resistance in recent years. In continuation of our efforts in identifying the new small molecule antiviral and anticancer agents, we identified chalcones as potent antiviral and anticancer agents. OBJECTIVE: With the aim of identifying the broad acting antiviral and anticancer agents, we discovered substituted aryl/heteroaryl derived thienyl chalcones as antiviral and anticancer agents...
May 23, 2018: Medicinal Chemistry
https://www.readbyqxmd.com/read/29791951/nervous-system-infections-and-the-global-traveler
#3
Savina Reid, Haley Thompson, Kiran T Thakur
Neurological complications of infectious diseases are associated with high rates of morbidity and mortality. It is imperative that neurologists be up-to-date on current developments including typical and atypical presentations of neurological infections in travelers, diagnostic and treatment recommendations, and emerging pathogen resistance patterns to avoid fatal outcomes and long-term sequelae. This article will address concepts of emerging and reemerging infectious diseases, and will provide updates on the neurological manifestations of select emerging and reemerging infections, including Ebola virus, bacterial meningitis, enterovirus 71, Zika virus, cerebral malaria, and Japanese encephalitis...
April 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29791942/emerging-viral-infections-and-their-impact-on-the-global-burden-of-neurological-disease
#4
Laura S Muñoz, Maria A Garcia, Eliza Gordon-Lipkin, Beatriz Parra, Carlos A Pardo
Emerging viral infections of the nervous system represent a major global public health concern in the 21st century. They are caused primarily by RNA viruses and are mostly associated with acute or subacute encephalitis. The spectrum of associated central or peripheral nervous system disorders is broad, and results either from a direct viral effect or due to the host immune responses against the infection. Emerging viral infections impose substantial neurological morbidity and mortality, particularly in low- and middle-income regions...
April 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29791940/global-neurology-navigating-career-possibilities
#5
Nicoline Schiess, Deanna Saylor, Joseph Zunt
Neurology has not typically been associated with international relief work; however, with the growth of chronic cardiovascular disease and stroke associated with unhealthy eating and sedentary ways, the appearance of "new" neurologic diseases, such as the Zika and West Nile viruses, and the high numbers of seizure disorders resulting from neuroinfectious diseases, more opportunities are arising for international and globally oriented neurologists. Multiple opportunities exist for developing a global clinician-educator career pathway, including private institutions, nongovernmental organizations, government-funded opportunities such as Medical Education Partnership Initiative, Fogarty and Fulbright Scholarships, and the American Academy of Neurology's Global Health Section...
April 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29791591/searching-for-the-best-real-time-rt-pcrs-to-detect-zika-virus-infections-the-importance-of-comparing-several-protocols
#6
F M de Moraes, D L A Espósito, T M Klein, B A L da Fonseca
Clinical manifestations of Zika, dengue, and chikungunya virus infections are very similar, making it difficult to reach a diagnosis based only on clinical grounds. In addition, there is an intense cross-reactivity between antibodies directed to Zika virus and other flaviviruses, and an accurate Zika diagnosis is best achieved by real-time RT-PCR. However, some real-time RT-PCR show better performance than others. To reach the best possible Zika diagnosis, the analytic sensitivity of some probe-based real-time RT-PCR amplifying Zika virus RNA was evaluated in spiked and clinical samples...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29789369/-wolbachia-w-stri-blocks-zika-virus-growth-at-two-independent-stages-of-viral-replication
#7
M J Schultz, A L Tan, C N Gray, S Isern, S F Michael, H M Frydman, J H Connor
Mosquito-transmitted viruses are spread globally and present a great risk to human health. Among the many approaches investigated to limit the diseases caused by these viruses are attempts to make mosquitos resistant to virus infection. Coinfection of mosquitos with the bacterium Wolbachia pipientis from supergroup A is a recent strategy employed to reduce the capacity for major vectors in the Aedes mosquito genus to transmit viruses, including dengue virus (DENV), Chikungunya virus (CHIKV), and Zika virus (ZIKV)...
May 22, 2018: MBio
https://www.readbyqxmd.com/read/29789095/you-re-the-flight-surgeon
#8
(no author information available yet)
Holmes RL. You're the flight surgeon: zika virus infection. Aerosp Med Hum Perform. 2018; 89(6):572-575.
June 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29788488/surveillance-of-mosquitoes-diptera-culicidae-in-southern-iowa-2016
#9
Kristofer B Kovach, Ryan C Smith
The mosquito fauna of Iowa has been extensively investigated over several decades, providing a wealth of information regarding species distributions, relative abundance, temporal activity patterns, and identifying vectors of medical importance. However, these investigations have had unequal coverage, leaving the mosquito fauna in some parts of the state, including southern Iowa, largely uncharacterized. With the heightened public health threat of Zika virus in the summer of 2016, greater emphasis was placed on surveying for two potential Zika virus vectors: Aedes (Stegomyia) albopictus (Skuse) and Aedes (Stegomyia) aegypti (Linnaeus)...
May 19, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29788443/pediatric-infectious-diseases-meets-the-future
#10
Janet R Gilsdorf, Paul Spearman, Janet A Englund, Tina Q Tan, Kristina A Bryant
Pediatric infectious diseases physicians are dedicated to the diagnosis, prevention, and management of infections in children. As such, we play large, and important, roles in the clinical care of children from birth to late adolescence and in infection prevention, antimicrobial stewardship, research pertaining to infections, public health, international and global health, and advocacy for children's health. Furthermore, we are critical to the education of future physicians (in general), pediatricians, and infectious diseases doctors...
May 19, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29786689/gridded-birth-and-pregnancy-datasets-for-africa-latin-america-and-the-caribbean
#11
W H M James, N Tejedor-Garavito, S E Hanspal, A Campbell-Sutton, G M Hornby, C Pezzulo, K Nilsen, A Sorichetta, C W Ruktanonchai, A Carioli, D Kerr, Z Matthews, A J Tatem
Understanding the fine scale spatial distribution of births and pregnancies is crucial for informing planning decisions related to public health. This is especially important in lower income countries where infectious disease is a major concern for pregnant women and new-borns, as highlighted by the recent Zika virus epidemic. Despite this, the spatial detail of basic data on the numbers and distribution of births and pregnancies is often of a coarse resolution and difficult to obtain, with no co-ordination between countries and organisations to create one consistent set of subnational estimates...
May 22, 2018: Scientific Data
https://www.readbyqxmd.com/read/29785356/examining-the-potential-for-south-american-arboviruses-to-spread-beyond-the-new-world
#12
Víctor Hugo Peña-García, Michael K McCracken, Rebecca C Christofferson
Zika and chikungunya viruses emerged as public health emergencies in the Western Hemisphere where previously they had not been reported on a large scale. Millions were infected as the viruses met with virtually no herd immunity upon emergence. Purpose of the Review: We explore the histories of these two recent arbovirus experiences in South America. We then review similarly three endemic South American viruses: yellow fever, Oropouche, and Mayaro viruses. Recent Findings: We discuss the commonalities of the transmission systems and the possibility of an atypical emergence, that of New World virus to the Old World...
December 2017: Current Clinical Microbiology Reports
https://www.readbyqxmd.com/read/29785319/a-multi-faceted-pandemic-a-review-of-the-state-of-knowledge-on-the-zika-virus
#13
REVIEW
Anneliese Depoux, Aline Philibert, Serge Rabier, Henri-Jean Philippe, Arnaud Fontanet, Antoine Flahault
While until recently the small and isolated Zika outbreaks in Eastern Asia and Pacific islands had been overlooked, the large-scale outbreak that started in Brazil in 2015 and the increase of microcephaly cases in the same place and time made media headlines. Considered as harmless until recently, Zika has given rise to an important global crisis that poses not only health challenges but also environmental, economical, social, and ethical challenges for states and people around the world. The main objective of this paper is to review the recent Zika outbreak by covering a broad range of disciplines and their interactions...
2018: Public Health Reviews
https://www.readbyqxmd.com/read/29782922/dengue-chikungunya-and-zika-infections-imported-to-paris-between-2009-and-2016-characteristics-and-correlation-with-outbreaks-in-the-french-overseas-territories-of-guadeloupe-and-martinique
#14
Victor Vasquez, Elie Haddad, Alice Perignon, Stéphane Jaureguiberry, Ségolène Brichler, Isabelle Leparc-Goffart, Eric Caumes
BACKGROUND: Dengue (DV), chikungunya (CV) and Zika virus (ZV) infections are rapidly expanding across countries and diagnosed in returned travelers who represent epidemiological sentinels. French Territories of America (FTA) such as Guadeloupe and Martinique are highly touristic places and have experienced three consecutive outbreaks by such viruses in the last decade. OBJECTIVE: We evaluated how ill returned travelers could be deemed as epidemiological sentinels for these three expanding arboviral diseases during eight consecutive years...
May 18, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29782512/regulation-of-midgut-cell-proliferation-impacts-aedes-aegypti-susceptibility-to-dengue-virus
#15
Mabel L Taracena, Vanessa Bottino-Rojas, Octavio A C Talyuli, Ana Beatriz Walter-Nuno, José Henrique M Oliveira, Yesseinia I Angleró-Rodriguez, Michael B Wells, George Dimopoulos, Pedro L Oliveira, Gabriela O Paiva-Silva
Aedes aegypti is the vector of some of the most important vector-borne diseases like dengue, chikungunya, zika and yellow fever, affecting millions of people worldwide. The cellular processes that follow a blood meal in the mosquito midgut are directly associated with pathogen transmission. We studied the homeostatic response of the midgut against oxidative stress, as well as bacterial and dengue virus (DENV) infections, focusing on the proliferative ability of the intestinal stem cells (ISC). Inhibition of the peritrophic matrix (PM) formation led to an increase in reactive oxygen species (ROS) production by the epithelial cells in response to contact with the resident microbiota, suggesting that maintenance of low levels of ROS in the intestinal lumen is key to keep ISCs division in balance...
May 21, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29780762/framing-and-visual-type-effect-on-future-zika-vaccine-uptake-intent
#16
Jeanine P D Guidry, Kellie E Carlyle, Jessica G LaRose, Paul Perrin, Mark Ryan, Marcus Messner, Jay Adams
Introduction: The Zika virus is associated with the birth defect microcephaly, and while a vaccine was not available in early- 2017, several were under development. This study's purpose was to identify effective communication strategies to promote uptake of a new vaccine, particularly among women of reproductive age. Design and methods: In order to study the effects of Zika message framing (gain vs . loss) and visual type (photo vs . infographic) on future Zika vaccine uptake intent, a 2×2 between-subjects experiment was performed via an online survey in 2017 among 339 U...
February 5, 2018: Journal of Public Health Research
https://www.readbyqxmd.com/read/29779827/zika-virus-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#17
Gisele Sampaio Silva, Guy A Richards, Tim Baker, Jorge Hidalgo, Juan Ignacio Silesky Jiménez, Pravin Amin
Zika fever is an acute infectious disease caused by the Zika virus (ZIKV), an RNA virus belonging to the genus Flavivirus. ZIKV can be transmitted by bites from Aedes aegypti and Aedes albopictus species, sexual activity, blood transfusion and from mother to fetus during pregnancy and delivery. A total of 50 territories and countries in the Americas had reported ZIKV infections. For those with symptoms, the presentation is similar to dengue fever with body aches, joint pain, fatigue, malaise, fever and conjunctivitis lasting up to seven days...
April 5, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29779454/vaccinia-based-vaccines-to-biothreat-and-emerging-viruses
#18
Les P Nagata, Chad R Irwin, Wei-Gang Hu, David H Evans
The past few years have seen a rash of emerging viral diseases, including the Ebola crisis in West Africa, the pandemic spread of chikungunya, and the recent explosion of Zika in South America. Vaccination is the most reliable and cost-effective method of control of infectious diseases, however, there is often a long delay in production and approval in getting new vaccines to market. Vaccinia was the first vaccine developed for the successful eradication of smallpox and has properties that make it attractive as a universal vaccine vector...
May 21, 2018: Biotechnology & Genetic Engineering Reviews
https://www.readbyqxmd.com/read/29777926/epidemiology-of-acute-febrile-illness-in-latin-america
#19
REVIEW
José Moreira, Clarisse S Bressan, Patricia Brasil, Andre M Siqueira
BACKGROUND: The causes of acute febrile illness (AFI) in Latin America (LA) are diverse and its complexity increase as the proportion of fever due to malaria decreases as control and new pathogens emerge in the region. In this context, it is important to shed light over the gaps on the epidemiological characteristics and the geographic range for many AFI aetiologies. AIMS: To review studies on community-acquired fever etiology other than malaria in LA, and to highlight knowledge gaps and challenges needing further investigation...
May 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29777650/modeling-dengue-vector-population-using-remotely-sensed-data-and-machine-learning
#20
Juan M Scavuzzo, Francisco Trucco, Manuel Espinosa, Carolina B Tauro, Marcelo Abril, Carlos M Scavuzzo, Alejandro C Frery
Mosquitoes are vectors of many human diseases. In particular, Aedes ægypti (Linnaeus) is the main vector for Chikungunya, Dengue, and Zika viruses in Latin America and it represents a global threat. Public health policies that aim at combating this vector require dependable and timely information, which is usually expensive to obtain with field campaigns. For this reason, several efforts have been done to use remote sensing due to its reduced cost. The present work includes the temporal modeling of the oviposition activity (measured weekly on 50 ovitraps in a north Argentinean city) of Aedes ægypti (Linnaeus), based on time series of data extracted from operational earth observation satellite images...
May 16, 2018: Acta Tropica
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