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https://www.readbyqxmd.com/read/27936448/flavivirus-transmission-focusing-on-zika
#1
REVIEW
Nikos Vasilakis, Scott C Weaver
Flaviviruses are among the most diverse viruses with over 85 species recognized. Taxonomically, this genus is one of the 4 recognized genera within the family Flaviviridae. Most flaviviruses of human public health significance, for example, dengue, yellow fever and Zika viruses, are arthropod-borne (arboviruses) and have two evolutionarily and ecologically distinct transmission cycles: a sylvatic transmission cycle, where the virus circulates between zoonotic vertebrate reservoir and amplification hosts and arboreal mosquitoes; and an urban transmission cycle, where the virus circulates between humans and peridomestic Aedes spp...
December 6, 2016: Current Opinion in Virology
https://www.readbyqxmd.com/read/27934901/towards-peptide-vaccines-against-zika-virus-immunoinformatics-combined-with-molecular-dynamics-simulations-to-predict-antigenic-epitopes-of-zika-viral-proteins
#2
Muhammad Usman Mirza, Shazia Rafique, Amjad Ali, Mobeen Munir, Nazia Ikram, Abdul Manan, Outi M H Salo-Ahen, Muhammad Idrees
The recent outbreak of Zika virus (ZIKV) infection in Brazil has developed to a global health concern due to its likely association with birth defects (primary microcephaly) and neurological complications. Consequently, there is an urgent need to develop a vaccine to prevent or a medicine to treat the infection. In this study, immunoinformatics approach was employed to predict antigenic epitopes of Zika viral proteins to aid in development of a peptide vaccine against ZIKV. Both linear and conformational B-cell epitopes as well as cytotoxic T-lymphocyte (CTL) epitopes were predicted for ZIKV Envelope (E), NS3 and NS5 proteins...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27934884/rapid-affordable-and-portable-medium-throughput-molecular-device-for-zika-virus
#3
Kamfai Chan, Scott C Weaver, Pui-Yan Wong, Sherly Lie, Eryu Wang, Mathilde Guerbois, Siva Praneeth Vayugundla, Season Wong
Zika virus (ZIKV) has gained global attention as an etiologic agent of fetal microcephaly and Guillain-Barré syndrome. Existing immuno-based rapid tests often fail to distinguish between Zika and related flaviviruses that are common in affected regions of Central and South Americas and the Caribbean. The US CDC and qualified state health department laboratories can perform the reverse transcription polymerase chain reaction (RT-PCR) ZIKV test using highly sophisticated instruments with long turnaround times...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27934765/zika-virus-produces-noncoding-rnas-using-a-multi-pseudoknot-structure-that-confounds-a-cellular-exonuclease
#4
Benjamin M Akiyama, Hannah M Laurence, Aaron R Massey, David A Costantino, Xuping Xie, Yujiao Yang, Pei-Yong Shi, Jay C Nix, J David Beckham, Jeffrey S Kieft
The outbreak of Zika virus (ZIKV) and associated fetal microcephaly mandates efforts to understand the molecular processes of infection. Related flaviviruses produce noncoding subgenomic flaviviral RNAs (sfRNAs) that are linked to pathogenicity in fetal mice. These viruses make sfRNAs by co-opting a cellular exonuclease via structured RNAs called xrRNAs. We found that ZIKV-infected monkey and human epithelial cells, mouse neurons, and mosquito cells produce sfRNAs. The RNA structure that is responsible for ZIKV sfRNA production forms a complex fold that is likely found in many pathogenic flaviviruses...
December 2, 2016: Science
https://www.readbyqxmd.com/read/27934740/zika-virus-is-fit-to-be-tied
#5
EDITORIAL
Kristen L Mueller
No abstract text is available yet for this article.
December 2, 2016: Science
https://www.readbyqxmd.com/read/27932779/erratum-vol-65-no-44
#6
(no author information available yet)
In the report, "Incidence of Zika Virus Disease by Age and Sex - Puerto Rico, November 1, 2015-October 20, 2016," on page 1219 the following person should have been included as an author: Luisa I. Alvarado, MD, Ponce Health Sciences University-Saint Luke's Episcopal Hospital Consortium, Puerto Rico.
December 9, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27932442/contraceptive-sales-in-the-setting-of-the-zika-virus-epidemic
#7
Luis Bahamondes, Moazzam Ali, Ilza Monteiro, Arlete Fernandes
STUDY QUESTION: Has there been any influence of the Zika virus (ZIKV) outbreak on the sales of contraceptive methods in Brazil? SUMMARY ANSWER: Contraceptive sales in the 24 months of evaluation showed little variation and no significant change has been observed since the ZIKV outbreak. WHAT IS KNOWN ALREADY: Transmission of ZIKV is primarily by Aedes aegypti mosquitoes; however, sexual transmission has also been described. The association of several birth defects and the ZIKV infection during pregnancy has been established, and it was estimated in Bahia, Brazil that the infection rate could range from 10% to 80%...
December 7, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27930910/the-neurobiology-of-zika-virus
#8
REVIEW
Hongda Li, Laura Saucedo-Cuevas, Sujan Shresta, Joseph G Gleeson
Zika virus (ZIVK) represents a new threat to global health, with particular relevance to neuroscientists, due to associated newborn and adult neurological disease. Consequences of vertical infection include microcephaly with brain and eye anomalies, and consequences of adult infection include Guillain-Barré syndrome (GBS) and meningoencephalitis. Recent data suggest specific vulnerability of neural progenitors to infection, leading to cell death and brain calcification, reminiscent of other viral syndromes...
December 7, 2016: Neuron
https://www.readbyqxmd.com/read/27929575/zika-virus-and-guillain-barr%C3%A3-syndrome
#9
M A Ellul, C N Soares, T Solomon
No abstract text is available yet for this article.
June 2016: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/27929451/the-self-regulation-model-of-illness-comparison-between-zika-and-dengue-and-its-application-to-predict-mosquito-prevention-behaviours-in-malaysia-a-dengue-endemic-country
#10
Li Ping Wong, Haridah Alias, Nasrin Aghamohammadi, I-Ching Sam, Sazaly AbuBakar
Perceptions about illnesses may influence self-care and preventive health behaviours. Illness perceptions of the Zika virus (ZIKV) infection were investigated under the framework of the Self-Regulation Model of Illness. Illness perception differences between ZIKV and dengue fever were also examined. Lastly, associations between illness perceptions of ZIKV with mosquito prevention practices were studied. Samples were drawn from landline telephone numbers using computer-assisted telephone interviewing in Malaysia...
December 6, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27929218/emerging-vector-borne-diseases
#11
Mark K Huntington, Jay Allison, Dilip Nair
Several mosquito-borne viral infections have recently emerged in North America; West Nile virus is the most common in the United States. Although West Nile virus generally causes a self-limited, flulike febrile illness, a serious neuroinvasive form may occur. Dengue is the most common vector-borne viral disease worldwide, and it has been a significant public health threat in the United States since 2009. Known as breakbone fever for its severe myalgias and arthralgias, dengue may cause a hemorrhagic syndrome...
October 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27927917/zika-virus-testing-considerations-lessons-learned-from-the-first-eighty-real-time-rt-pcr-positive-cases-diagnosed-in-new-york-state
#12
Kirsten St George, Inderbir S Sohi, Elizabeth M Dufort, Amy B Dean, Jennifer L White, Ronald Limberger, Jamie N Sommer, Stephanie Ostrowski, Susan J Wong, P Bryon Backenson, Daniel Kuhles, Debra Blog, Jill Taylor, Brad Hutton, Howard A Zucker
The performance and interpretation of laboratory tests for Zika virus (ZKV) continue to be evaluated. Serology is cross-reactive, laborious and frequently difficult to interpret and serum was initially solely recommended for molecular diagnosis. ZKV testing was initiated January 2016 in New York State for symptomatic patients, pregnant women, their infants, and patients with Guillain-Barré Syndrome, who traveled to areas with ZKV transmission. Subsequently, eligibility was expanded to pregnant women with sexual partners with similar travel history...
December 7, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27927858/transient-hearing-loss-in-adults-associated-with-zika-virus-infection
#13
Eriko S Vinhaes, Luciane A Santos, Lislane Dias, Nilvano A Andrade, Victor H Bezerra, Anderson T de Carvalho, Laise de Moraes, Daniele F Henriques, Sasha R Azar, Nikos Vasilakis, Albert I Ko, Bruno B Andrade, Isadora C Siqueira, Ricardo Khouri, Viviane S Boaventura
In 2015, during the outbreak of ZIKAV in Brazil, we identified three cases of acute hearing loss after exanthematous illness. Serology yielded finding compatible with ZIKAV as the cause of a confirmed (1patient) and a probable (2 patients) flavivirus infection, indicating an association between ZIKAV infection and transient hearing loss.
December 7, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27927093/optomotor-reactions-reveal-polarization-sensitvity-in-the-zika-virus-transmitting-yellow-fever-mosquito-aedes-stegomyia-aegypti-diptera-nematocera
#14
Balazs Bernáth, Victor Benno Meyer-Rochow
In polarization-sensitive insect species an orthogonal arrangement of photoreceptive microvilli is a characteristic feature. However, mosquito eyes had not revealed this feature, and polarization sensitivity (PS) was considered to be non-existent in them. Recently, however, gravid Aedes (Stegomyia) aegypti females were found to possess PS, sequels of which could be demonstrated only in the absence of chemicals emitted by conspecifics. Therefore, PS in Ae. aegypti, unlike that of other aquatic insects, apparently does not play a dominant role in locating water bodies, and is difficult to demonstrate in situations free of chemical cues...
December 2016: Zoological Science
https://www.readbyqxmd.com/read/27926933/comparative-analysis-of-dengue-and-zika-outbreaks-reveals-differences-by-setting-and-virus
#15
Sebastian Funk, Adam J Kucharski, Anton Camacho, Rosalind M Eggo, Laith Yakob, Lawrence M Murray, W John Edmunds
The pacific islands of Micronesia have experienced several outbreaks of mosquito-borne diseases over the past decade. In outbreaks on small islands, the susceptible population is usually well defined, and there is no co-circulation of pathogens. Because of this, analysing such outbreaks can be useful for understanding the transmission dynamics of the pathogens involved, and particularly so for yet understudied pathogens such as Zika virus. Here, we compared three outbreaks of dengue and Zika virus in two different island settings in Micronesia, the Yap Main Islands and Fais, using a mathematical model of transmission dynamics and making full use of commonalities in disease and setting between the outbreaks...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27926355/characteristics-of-us-travelers-to-zika-virus-affected-countries-in-the-americas-march-2015-october-2016
#16
Sara Lammert, Allison Taylor Walker, Stefanie Erskine, Sowmya R Rao, Douglas H Esposito, Edward T Ryan, Gregory K Robbins, Regina C LaRocque
Zika virus has recently been introduced to the Americas and is spreading rapidly. We evaluated the characteristics of US travelers to Zika virus-affected countries who were seen at Global TravEpiNet sites during March 2015-October 2016. Nearly three quarters of travelers were men or women of reproductive age.
February 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27923950/results-of-a-zika-virus-zikv-immunoglobulin-m-specific-diagnostic-assay-are-highly-correlated-with-detection-of-neutralizing-anti-zikv-antibodies-in-neonates-with-congenital-disease
#17
Marli T Cordeiro, Carlos A A Brito, Lindomar J Pena, Priscila M S Castanha, Laura H V G Gil, Kennya G S Lopes, Rafael Dhalia, Jucille A Meneses, Ana C Ishigami, Luisa M Mello, Liciana X E Alencar, Klarissa M Guarines, Laura C Rodrigues, Ernesto T A Marques
BACKGROUND:  Usually, immunoglobulin M (IgM) serologic analysis is not sufficiently specific to confirm Zika virus (ZIKV) infection. However, since IgM does not cross the placenta, it may be a good marker of infection in neonates. METHODS:  We tested blood from 42 mothers and neonates with microcephaly and collected cerebrospinal fluid (CSF) specimens from 30 neonates. Molecular assays were performed for detection of ZIKV, dengue virus, and chikungunya virus; IgM enzyme-linked immunosorbent assays and plaque-reduction neutralization tests (PRNTs) were performed to detect ZIKV and dengue virus...
December 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27923889/zika-virus-a-serious-global-health-threat
#18
Candice J McNeil, Avinash K Shetty
In February 2016, the World Health Organization declared Zika virus (ZIKV) infection a public health emergency of international concern, given the precipitous spread of the virus across the Americas. Unlike arboviruses such as Chikungunya and Dengue, which have also recently emerged in the western hemisphere, ZIKV was identified in communities where concurrent neurologic conditions such as microcephaly and Guillain-Barre (GB) syndrome were occurring at alarming rates. Thus, investigations to systematically evaluate the link between ZIKV, congenital malformations (including microcephaly) and GB syndrome remain a top priority...
December 5, 2016: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/27923187/sleep-eeg-patterns-in-infants-with-congenital-zika-virus-syndrome
#19
Maria Durce Costa Gomes Carvalho, Demócrito de Barros Miranda-Filho, Vanessa van der Linden, Paula Fabiana Sobral, Regina Coeli Ferreira Ramos, Maria Ângela Wanderley Rocha, Marli Tenório Cordeiro, Sarah Pinheiro de Alencar, Magda Lahorgue Nunes
OBJECTIVES: To describe sleep EEG patterns of neonates, and infants with microcephaly due to congenital Zika virus (ZikV) syndrome. METHODS: A descriptive case series of EEGs performed in a cohort of neonates with microcephaly monitored from October 2015 to February 2016 at a University Hospital in Northeast Brazil. Infants were investigated following an established protocol that includes EEG, neuroimaging studies, PCR and specific antibodies for ZikV detection...
November 14, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27922617/transfer-of-convalescent-serum-to-pregnant-mice-prevents-zika-virus-infection-and-microcephaly-in-offspring
#20
Shuo Wang, Shuai Hong, Yong-Qiang Deng, Qing Ye, Ling-Zhai Zhao, Fu-Chun Zhang, Cheng-Feng Qin, Zhiheng Xu
No abstract text is available yet for this article.
December 6, 2016: Cell Research
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