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https://www.readbyqxmd.com/read/28340344/modified-mrna-vaccines-protect-against-zika-virus-infection
#1
Justin M Richner, Sunny Himansu, Kimberly A Dowd, Scott L Butler, Vanessa Salazar, Julie M Fox, Justin G Julander, William W Tang, Sujan Shresta, Theodore C Pierson, Giuseppe Ciaramella, Michael S Diamond
No abstract text is available yet for this article.
March 23, 2017: Cell
https://www.readbyqxmd.com/read/28339472/vector-status-of-aedes-species-determines-geographical-risk-of-autochthonous-zika-virus-establishment
#2
Lauren Gardner, Nan Chen, Sahotra Sarkar
BACKGROUND: The 2015-16 Zika virus pandemic originating in Latin America led to predictions of a catastrophic global spread of the disease. Since the current outbreak began in Brazil in May 2015 local transmission of Zika has been reported in over 60 countries and territories, with over 750 thousand confirmed and suspected cases. As a result of its range expansion attention has focused on possible modes of transmission, of which the arthropod vector-based disease spread cycle involving Aedes species is believed to be the most important...
March 24, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28339458/rapid-surveillance-for-vector-presence-rsvp-development-of-a-novel-system-for-detecting-aedes-aegypti-and-aedes-albopictus
#3
Brian L Montgomery, Martin A Shivas, Sonja Hall-Mendelin, Jim Edwards, Nicholas A Hamilton, Cassie C Jansen, Jamie L McMahon, David Warrilow, Andrew F van den Hurk
BACKGROUND: The globally important Zika, dengue and chikungunya viruses are primarily transmitted by the invasive mosquitoes, Aedes aegypti and Aedes albopictus. In Australia, there is an increasing risk that these species may invade highly urbanized regions and trigger outbreaks. We describe the development of a Rapid Surveillance for Vector Presence (RSVP) system to expedite presence- absence surveys for both species. METHODOLOGY/PRINCIPAL FINDINGS: We developed a methodology that uses molecular assays to efficiently screen pooled ovitrap (egg trap) samples for traces of target species ribosomal RNA...
March 24, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28335029/the-challenge-of-assessing-microcephaly-in-the-context-of-the-zika-virus-epidemic
#4
Llorenç Quintó, Alberto L García-Basteiro, Azucena Bardají, Raquel González, Norma Padilla, Flor E Martinez-Espinosa, Myriam Arévalo-Herrera, Eusébio Macete, Clara Menéndez
The present article examines the impact of the current limitations of the microcephaly definition in the context of the Zika virus outbreak. It highlights its dependence on the method used for determining gestational age and other anthropometric parameters, and includes original results of prevalence of microcephaly in four countries from two different continents (Mozambique, Brazil, Guatemala and Colombia). Alternative definitions of microcephaly are proposed to allow the identification of true cases of microcephaly in a more accurate manner...
March 10, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28333986/building-the-road-to-a-regional-zoonoses-strategy-a-survey-of-zoonoses-programmes-in-the-americas
#5
Melody J Maxwell, Mary H Freire de Carvalho, Armando E Hoet, Marco A N Vigilato, Julio C Pompei, Ottorino Cosivi, Victor J Del Rio Vilas
BACKGROUND: In recent years, global public health security has been threatened by zoonotic disease emergence as exemplified by outbreaks of H5N1 and H1N1 influenza, SARS, and most recently Ebola and Zika. Additionally, endemic zoonoses, such as rabies, burden countries year after year, placing demands on limited finances and personnel. To survey the baseline status of the emerging and endemic zoonoses programmes of the Latin American and the Caribbean (LAC) countries, the Pan American Health Organization (PAHO) conducted a survey of priority emerging and endemic zoonoses, countries´ prioritization criteria and methodologies, and suggestions to strengthen countries capacities and regional approaches to zoonoses control...
2017: PloS One
https://www.readbyqxmd.com/read/28333910/establishing-a-timeline-to-discontinue-routine-testing-of-asymptomatic-pregnant-women-for-zika-virus-infection-american-samoa-2016-2017
#6
W Thane Hancock, Heidi M Soeters, Susan L Hills, Ruth Link-Gelles, Mary E Evans, W Randolph Daley, Emily Piercefield, Magele Scott Anesi, Mary Aseta Mataia, Anaise M Uso, Benjamin Sili, Aifili John Tufa, Jacqueline Solaita, Elizabeth Irvin-Barnwell, Dana Meaney-Delman, Jason Wilken, Paul Weidle, Karrie-Ann E Toews, William Walker, Phillip M Talboy, William K Gallo, Nevin Krishna, Rebecca L Laws, Megan R Reynolds, Alaya Koneru, Carolyn V Gould
The first patients with laboratory-confirmed cases of Zika virus disease in American Samoa had symptom onset in January 2016 (1). In response, the American Samoa Department of Health (ASDoH) implemented mosquito control measures (1), strategies to protect pregnant women (1), syndromic surveillance based on electronic health record (EHR) reports (1), Zika virus testing of persons with one or more signs or symptoms of Zika virus disease (fever, rash, arthralgia, or conjunctivitis) (1-3), and routine testing of all asymptomatic pregnant women in accordance with CDC guidance (2,3)(...
March 24, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28332092/the-spectrum-of-neuropathological-changes-associated-with-congenital-zika-virus-infection
#7
Leila Chimelli, Adriana S O Melo, Elyzabeth Avvad-Portari, Clayton A Wiley, Aline H S Camacho, Vania S Lopes, Heloisa N Machado, Cecilia V Andrade, Dione C A Dock, Maria Elisabeth Moreira, Fernanda Tovar-Moll, Patricia S Oliveira-Szejnfeld, Angela C G Carvalho, Odile N Ugarte, Alba G M Batista, Melania M R Amorim, Fabiana O Melo, Thales A Ferreira, Jacqueline R L Marinho, Girlene S Azevedo, Jeime I B F Leal, Rodrigo F Madeiro da Costa, Stevens Rehen, Monica B Arruda, Rodrigo M Brindeiro, Rodrigo Delvechio, Renato S Aguiar, Amilcar Tanuri
A major concern associated with ZIKV infection is the increased incidence of microcephaly with frequent calcifications in infants born from infected mothers. To date, postmortem analysis of the central nervous system (CNS) in congenital infection is limited to individual reports or small series. We report a comprehensive neuropathological study in ten newborn babies infected with ZIKV during pregnancy, including the spinal cords and dorsal root ganglia (DRG), and also muscle, pituitaries, eye, systemic organs, and placentas...
March 22, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28331858/zika-virus-an-emerging-epidemic
#8
EDITORIAL
Anna Ratanacharoensiri, Luke Huggins, Mark Johnson, Isha Patel
No abstract text is available yet for this article.
January 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/28331047/ascension-island-a-survey-to-assess-the-presence-of-zika-virus-vectors
#9
G Bullivant, A F Martinou
BACKGROUND AND AIM: Following concerns regarding the spread of Zika virus, Joint Services Health Unit (Cyprus) were tasked to carry out a mosquito survey on the Ascension Island, South Atlantic. This was to determine if vectors of the virus such as Aedes aegypti and Aedes albopictus were introduced and established on the Island. METHODS: An extensive survey of residential areas and natural habitats was initiated in order to collect mosquito larvae and adults by methods such as larval sampling, adult trapping and human landing catches...
March 22, 2017: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/28330900/adaptive-immune-responses-to-zika-virus-are-important-for-controlling-virus-infection-and-preventing-infection-in-brain-and-testes
#10
Clayton W Winkler, Lara M Myers, Tyson A Woods, Ronald J Messer, Aaron B Carmody, Kristin L McNally, Dana P Scott, Kim J Hasenkrug, Sonja M Best, Karin E Peterson
The recent association between Zika virus (ZIKV) and neurologic complications, including Guillain-Barré syndrome in adults and CNS abnormalities in fetuses, highlights the importance in understanding the immunological mechanisms controlling this emerging infection. Studies have indicated that ZIKV evades the human type I IFN response, suggesting a role for the adaptive immune response in resolving infection. However, the inability of ZIKV to antagonize the mouse IFN response renders the virus highly susceptible to circulating IFN in murine models...
March 22, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28330514/zika-virus-related-photo-sharing-on-pinterest-and-instagram
#11
Isaac Chun-Hai Fung, Elizabeth B Blankenship, M Elizabeth Goff, Lindsay A Mullican, Kwun Cheung Chan, Nitin Saroha, Carmen H Duke, Marina E Eremeeva, King-Wa Fu, Zion Tsz Ho Tse
OBJECTIVE: Pinterest (San Francisco, CA) and Instagram (Menlo Park, CA) are 2 popular photo-sharing social media platforms among young individuals. We assessed differences between Instagram and Pinterest in relaying photographic information regarding Zika virus. Specifically, we investigated whether the percentage of Zika-virus-related photos with Spanish or Portuguese texts embedded therein was higher for Instagram than for Pinterest and whether the contents of Zika-virus-related photos shared on Pinterest were different from those shared on Instagram...
March 23, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28329257/lessons-learned-at-the-epicenter-of-brazil-s-congenital-zika-epidemic-evidence-from-87-confirmed-cases
#12
Jucille do Amaral Meneses, Ana Catarina Ishigami, Luisa Medeiros de Mello, Luciano Lira de Albuquerque, Carlos Alexandre Antunes de Brito, Marli Tenório Cordeiro, Lindomar José Pena
Congenital Zika virus infection has stimulated great international concern. A prospective case series of 87 infants with laboratory-confirmed congenital Zika syndrome (CZS) at the epicenter of the Brazilian Zika epidemic in Pernambuco state is presented. Mothers were interviewed for symptoms of possible Zika virus (ZIKV) infection during pregnancy and fetal ultrasounds were obtained. Infant cerebrospinal fluid (CSF) samples were tested for ZIKV specific antibodies and sera were screened for other congenital infections...
February 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28328129/the-phenotypic-spectrum-of-congenital-zika-syndrome
#13
Miguel Del Campo, Ian M L Feitosa, Erlane M Ribeiro, Dafne D G Horovitz, André L S Pessoa, Giovanny V A França, Alfredo García-Alix, Maria J R Doriqui, Hector Y C Wanderley, Maria V T Sanseverino, João I C F Neri, João M Pina-Neto, Emerson S Santos, Islane Verçosa, Mirlene C S P Cernach, Paula F V Medeiros, Saile C Kerbage, André A Silva, Vanessa van der Linden, Celina M T Martelli, Marli T Cordeiro, Rafael Dhalia, Fernanda S L Vianna, Cesar G Victora, Denise P Cavalcanti, Lavinia Schuler-Faccini
In October 2015, Zika virus (ZIKV) outbreak the Brazilian Ministry of Health (MoH). In response, the Brazilian Society of Medical Genetics established a task force (SBGM-ZETF) to study the phenotype of infants born with microcephaly due to ZIKV congenital infection and delineate the phenotypic spectrum of this newly recognized teratogen. This study was based on the clinical evaluation and neuroimaging of 83 infants born during the period from July, 2015 to March, 2016 and registered by the SBGM-ZETF. All 83 infants had significant findings on neuroimaging consistent with ZIKV congenital infection and 12 had confirmed ZIKV IgM in CSF...
April 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28327810/spatial-temporal-analysis-of-dengue-deaths-identifying-social-vulnerabilities
#14
Maria do Socorro da Silva, Maria Dos Remédios Freitas Carvalho Branco, José Aquino, Rejane Christine de Sousa Queiroz, Emanuele Bani, Emnielle Pinto Borges Moreira, Maria Nilza Lima Medeiros, Zulimar Márita Ribeiro Rodrigues
INTRODUCTION: Currently, dengue fever, chikungunya fever, and zika virus represent serious public health issues in Brazil, despite efforts to control the vector, the Aedes aegypti mosquito. METHODS: This was a descriptive and ecological study of dengue deaths occurring from 2002 to 2013 in São Luis, Maranhão, Brazil. Geoprocessing software was used to draw maps, linking the geo-referenced deaths with urban/social data at census tract level. RESULTS: There were 74 deaths, concentrated in areas of social vulnerability...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28327798/molecular-and-clinical-epidemiological-surveillance-of-dengue-virus-in-para%C3%A3-ba-northeast-brazil
#15
Isabel Cristina Guerra-Gomes, Bruna Macêdo Gois, Rephany Fonseca Peixoto, Camila Alves Oliveira, Bruna Leal Lima Maciel, Maria Izabel Ferreira Sarmento, Anna Stella Cysneiros Pachá, Josélio Maria Galvão Araújo, Ian Porto Gurgel Amaral, Tatjana Souza Lima Keesen
INTRODUCTION: Despite being the most prevalent arboviral disease worldwide, dengue has been neglected lately. However, recent epidemics of arboviruses such as Zika and chikungunya in locations throughout the world have alerted health authorities to these diseases. This study evaluated the incidence pattern of dengue, its clinical characteristics, and co-circulation of serotypes from 2007 to 2015 in Paraiba State, Northeast Brazil. METHODS: Data on dengue cases from 2007 to 2015 were extracted from clinical reports of the National System for Notifiable Diseases [Sistema Nacional de Agravos de Notificação (SINAN)] of Brazil provided by the Paraiba Health Department...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28327482/microcephaly-not-a-reliable-indicator-of-congenital-zika-virus-syndrome-in-infants
#16
Reeta S Mani
No abstract text is available yet for this article.
November 2016: National Medical Journal of India
https://www.readbyqxmd.com/read/28325935/a-comparison-study-of-zika-virus-outbreaks-in-french-polynesia-colombia-and-the-state-of-bahia-in-brazil
#17
Daihai He, Daozhou Gao, Yijun Lou, Shi Zhao, Shigui Ruan
Zika virus (ZIKV) disease outbreaks occurred in French Polynesia in 2013-2014 and in Brazil and Colombia in 2015-2016, respectively. Using our recently developed ZIKV disease model, we simulated the reported ZIKV infection cases from French Polynesia, Colombia and the State of Bahia of Brazil. Moreover, we estimated that the infection attack rates were 78.0% (95% confidence interval (CI): 63.5-86.3%) in French Polynesia which closely matches a previous serological study; 20.8% (95% CI: 1.1-50.0%) in Colombia which suggests that the attack rate was most likely less than 50%; and 32...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28325921/zika-virus-genome-biology-and-molecular-pathogenesis
#18
REVIEW
Anyou Wang, Stephanie Thurmond, Leonel Islas, Kingyung Hui, Rong Hai
Zika virus (ZIKV) is an emerging RNA virus in the widespread Flavivirus genus. Recently, ZIKV has rapidly spread around the world and has been implicated in human disease, including neurological disorders, triggering public and scientific attention. Understanding how ZIKV causes disease is the highest priority, yet little is known about this virus. Here we examine the currently published data from ZIKV studies to provide the latest understanding of ZIKV genome biology and molecular pathogenesis. The ZIKV genome evolved rapidly from the Flavivirus genus and diverged from the members of this genus, even within the dengue virus cluster to which ZIKV belongs...
March 22, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28325910/an-rna-nanoparticle-vaccine-against-zika-virus-elicits-antibody-and-cd8-t-cell-responses-in-a-mouse-model
#19
Jasdave S Chahal, Tao Fang, Andrew W Woodham, Omar F Khan, Jingjing Ling, Daniel G Anderson, Hidde L Ploegh
The Zika virus (ZIKV) outbreak in the Americas and South Pacific poses a significant burden on human health because of ZIKV's neurotropic effects in the course of fetal development. Vaccine candidates against ZIKV are coming online, but immunological tools to study anti-ZIKV responses in preclinical models, particularly T cell responses, remain sparse. We deployed RNA nanoparticle technology to create a vaccine candidate that elicited ZIKV E protein-specific IgG responses in C57BL/6 mice as assayed by ELISA...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28324177/a-detailed-analysis-of-codon-usage-patterns-and-influencing-factors-in-zika-virus
#20
Niraj K Singh, Anuj Tyagi
Recent outbreaks of Zika virus (ZIKV) in Africa, Latin America, Europe, and Southeast Asia have resulted in serious health concerns. To understand more about evolution and transmission of ZIKV, detailed codon usage analysis was performed for all available strains. A high effective number of codons (ENC) value indicated the presence of low codon usage bias in ZIKV. The effect of mutational pressure on codon usage bias was confirmed by significant correlations between nucleotide compositions at third codon positions and ENCs...
March 21, 2017: Archives of Virology
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