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https://www.readbyqxmd.com/read/28647173/an-update-on-zika-virus-infection
#1
REVIEW
David Baud, Duane J Gubler, Bruno Schaub, Marion C Lanteri, Didier Musso
The epidemic history of Zika virus began in 2007, with its emergence in Yap Island in the western Pacific, followed in 2013-14 by a larger epidemic in French Polynesia, south Pacific, where the first severe complications and non-vector-borne transmission of the virus were reported. Zika virus emerged in Brazil in 2015 and was declared a national public health emergency after local researchers and physicians reported an increase in microcephaly cases. In 2016, WHO declared the recent cluster of microcephaly cases and other neurological disorders reported in Brazil a global public health emergency...
June 21, 2017: Lancet
https://www.readbyqxmd.com/read/28647172/infection-related-microcephaly-after-the-2015-and-2016-zika-virus-outbreaks-in-brazil-a-surveillance-based-analysis
#2
Wanderson Kleber de Oliveira, Giovanny Vinícius Araújo de França, Eduardo Hage Carmo, Bruce Bartholow Duncan, Ricardo de Souza Kuchenbecker, Maria Inês Schmidt
BACKGROUND: On Nov 11, 2015, the Brazilian Ministry of Health declared a Public Health Emergency of National Concern in response to an increased number of microcephaly cases, possibly related to previous Zika virus outbreaks. We describe the course of the dual epidemics of the Zika virus infection during pregnancy and microcephaly in Brazil up to Nov 12, 2016, the first anniversary of this declaration. METHODS: We used secondary data for Zika virus and microcephaly cases obtained through the Brazilian Ministry of Health's surveillance systems from Jan 1, 2015, to Nov 12, 2016...
June 21, 2017: Lancet
https://www.readbyqxmd.com/read/28646879/discovery-of-a-single-male-aedes-aegypti-l-in-merseyside-england
#3
Thom Dallimore, Tony Hunter, Jolyon M Medlock, Alexander G C Vaux, Ralph E Harbach, Clare Strode
BACKGROUND: The mosquito Aedes aegypti (L.) is found in tropical and sub-tropical regions where it is the major vector of dengue fever, yellow fever, chikungunya and more recently Zika virus. Given its importance as a vector of arboviruses and its propensity to be transported to new regions, the European Centre for Disease Prevention and Control (ECDC) has placed Ae. aegypti on a list of potentially invasive mosquito species. It was previously reported in the United Kingdom (UK) in 1865 and 1919 but did not establish on either occasion...
June 24, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28646619/early-insights-into-zika-s-microcephaly-physiopathology-from-the-epicentre-of-the-outbreak-teratogenic-apoptosis-on-the-central-nervous-system
#4
Patricia Jungmann, Pedro Pires, Edward Araujo
Foetal infection by the Zika virus has been implicated in the exceptional rise in the number of mycrocephalic newborns recorded by the end of 2015 in Brazil. The mechanism by which this teratogenic effect is produced in the developing brain has not been entirely established. Very early in the outbreak, we addressed this question by evaluating available initial data from a gestational and post-natal clinical investigation in the Brazilian state of Pernambuco. The present study was undertaken to test the hypothesis that the subtractive dysmorphic brain malformations observed in Zika's microcephaly are primarily due to the massive induction of apoptosis of neuroprogenitor cells...
June 24, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28645459/-hotline-for-zika-virus-experience-of-a-tropical-and-travel-medicine-unit
#5
Marta Díaz-Menéndez, Fernando de la Calle-Prieto, Marta Arsuaga, Elena Trigo, Concepción Ladrón de Guevara, Pablo Barreiro, Clara Crespillo, Mar Lago
The current outbreak of Zika virus has caused great social alarm, generated in part by the lack of information in the general population. In order to provide accurate and verified information, the Tropical and Travel Medicine Unit of Hospital Carlos III-La Paz (Madrid, Spain) established a hotline for Zika virus infection. We present the data concerning the first 6 months of operation of the telephone hotline. The predominant call profile consisted of women seeking information about the risk of acquiring the disease before travelling...
June 20, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28645311/zika-virus-tropism-and-interactions-in-myelinating-neural-cell-cultures-cns-cells-and-myelin-are-preferentially-affected
#6
Stephanie L Cumberworth, Jennifer A Barrie, Madeleine E Cunningham, Daniely Paulino Gomes de Figueiredo, Verena Schultz, Adrian J Wilder-Smith, Benjamin Brennan, Lindomar J Pena, Rafael Freitas de Oliveira França, Christopher Linington, Susan C Barnett, Hugh J Willison, Alain Kohl, Julia M Edgar
The recent global outbreak of Zika virus (ZIKV) infection has been linked to severe neurological disorders affecting the peripheral and central nervous systems (PNS and CNS, respectively). The pathobiology underlying these diverse clinical phenotypes are the subject of intense research; however, even the principal neural cell types vulnerable to productive Zika infection remain poorly characterised. Here we used CNS and PNS myelinating cultures from wild type and Ifnar1 knockout mice to examine neuronal and glial tropism and short-term consequences of direct infection with a Brazilian variant of ZIKV...
June 23, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28644745/current-views-on-zika-virus-vaccine-development
#7
Luisa Barzon, Giorgio Palù
No abstract text is available yet for this article.
June 23, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28643807/infectious-disease-musashi-1-protein-could-mediate-the-effects-of-zika-virus-on-brain-development
#8
Heather Wood
No abstract text is available yet for this article.
June 23, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28643775/zika-virus-pathogenesis-in-rhesus-macaques-is-unaffected-by-pre-existing-immunity-to-dengue-virus
#9
Petraleigh Pantoja, Erick X Pérez-Guzmán, Idia V Rodríguez, Laura J White, Olga González, Crisanta Serrano, Luis Giavedoni, Vida Hodara, Lorna Cruz, Teresa Arana, Melween I Martínez, Mariah A Hassert, James D Brien, Amelia K Pinto, Aravinda de Silva, Carlos A Sariol
Zika virus (ZIKV) is a re-emerging virus that has recently spread into dengue virus (DENV) endemic regions and cross-reactive antibodies (Abs) could potentially affect ZIKV pathogenesis. Using DENV-immune serum, it has been shown in vitro that antibody-dependent enhancement (ADE) of ZIKV infection can occur. Here we study the effects of pre-existing DENV immunity on ZIKV infection in vivo. We infect two cohorts of rhesus macaques with ZIKV; one cohort has been exposed to DENV 2.8 years earlier and a second control cohort is naïve to flaviviral infection...
June 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28640798/evaluation-of-placental-and-fetal-tissue-specimens-for-zika-virus-infection-50-states-and-district-of-columbia-january-december-2016
#10
Sarah Reagan-Steiner, Regina Simeone, Elizabeth Simon, Julu Bhatnagar, Titilope Oduyebo, Rebecca Free, Amy M Denison, Demi B Rabeneck, Sascha Ellington, Emily Petersen, Joy Gary, Gillian Hale, M Kelly Keating, Roosecelis B Martines, Atis Muehlenbachs, Jana Ritter, Ellen Lee, Alexander Davidson, Erin Conners, Sarah Scotland, Kayleigh Sandhu, Andrea Bingham, Elizabeth Kassens, Lou Smith, Kirsten St George, Nina Ahmad, Mary Tanner, Suzanne Beavers, Brooke Miers, Kelley VanMaldeghem, Sumaiya Khan, Ingrid Rabe, Carolyn Gould, Dana Meaney-Delman, Margaret A Honein, Wun-Ju Shieh, Denise J Jamieson, Marc Fischer, Sherif R Zaki
Zika virus infection during pregnancy can cause congenital microcephaly and brain abnormalities (1), and detection of Zika virus RNA in clinical and tissue specimens can provide definitive laboratory evidence of recent Zika virus infection. Whereas duration of viremia is typically short, prolonged detection of Zika virus RNA in placental, fetal, and neonatal brain tissue has been reported and can provide key diagnostic information by confirming recent Zika virus infection (2). In accordance with recent guidance (3,4), CDC provides Zika virus testing of placental and fetal tissues in clinical situations where this information could add diagnostic value...
June 23, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28639081/clinical-impact-of-non-congenital-zika-virus-infection-in-infants-and-children
#11
REVIEW
Stefan H F Hagmann
PURPOSE OF REVIEW: While the Zika virus (ZIKV) has been noted for its distinct neurotropism and identified as a significant cause for a congenital infection syndrome, there has been increased recognition of the importance to better understand the clinical impact of non-congenital ZIKV infection in infants and children. This article reviews reports of perinatal and breast milk transmission of ZIKV and summarizes current clinical outcome data of pediatric non-congenital ZIKV infection. RECENT FINDINGS: Perinatal transmission and presence of infective ZIKV particles in breast milk have been reported...
June 21, 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28638845/detection-of-the-northeastern-african-rift-valley-fever-virus-lineage-during-the-2015-outbreak-in-mauritania
#12
Ndeye Sakha Bob, Hampâté Bâ, Gamou Fall, Elkhalil Ishagh, Mamadou Y Diallo, Abdourahmane Sow, Pape Mbacké Sembene, Ousmane Faye, Brahim El Kouri, Mohamed Lemine Sidi, Amadou Alpha Sall
BACKGROUND: Rift Valley fever (RVF) is an acute viral anthropozoonosis that causes epizootics and epidemics among livestock population and humans. Multiple emergences and reemergences of the virus have occurred in Mauritania over the last decade. This article describes the outbreak that occurred in 2015 in Mauritania and reports the results of serological and molecular investigations of blood samples collected from suspected RVF patients. METHODS: An RVF outbreak was reported from 14 September to 26 November 2015 in Mauritania...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28638259/global-alert-zika-virus-an-emerging-arbovirus
#13
REVIEW
Zulal Ozkurt, Esra Cinar Tanriverdi
Zika virus (ZIKV) is an arbovirus of the Flavivirus genus, and it has an envelope and a single RNA molecule. In early 2016, the World Health Organization declared ZIKV infection to be an emerging global health threat. The major transmission route of the virus to humans is Aedes mosquitoes. ZIKV can be transmitted between humans by transplacental, perinatal, and sexual routes and via blood and body fluids. ZIKV infection usually results in a mild and self-limiting disease with low-grade fever, conjunctivitis, and periorbital edema...
June 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28637753/structural-mimicry-of-the-dengue-virus-envelope-glycoprotein-revealed-by-the-crystallographic-study-of-an-idiotype-anti-idiotype-fab-complex
#14
Yee Hwa Wong, Boon Chong Goh, She Yah Lim, En Wei Teo, Angeline P C Lim, Pete C Dedon, Brendon J Hanson, Paul A MacAry, Julien Lescar
A detailed understanding of the fine specificity of serotype-specific human antibodies is vital for the development and evaluation of new vaccines for pathogenic Flaviviruses such as Dengue virus (DENV) and Zika virus. In this study, we thoroughly characterize the structural footprint of an anti-idiotype antibody (E1) specific for a potent, fully human DENV serotype 1-specific antibody termed HM14c10, derived from a recovered patient. The crystal structure at a resolution of 2.5 Å of a complex between the Fab fragments of E1 and HM14c10 provides the first detailed molecular comparison of an anti-idiotype paratope specific for a human antibody with its analogous epitope- a discontinuous quaternary structure located at the surface of the viral particle that spans adjacent envelope (E) proteins...
June 21, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28636449/zika-virus-in-ontario-evaluating-a-rapid-risk-assessment-tool-for-emerging-infectious-disease-threats
#15
Ryan Van Meer, Karin Hohenadel, Alanna Fitzgerald-Husek, Bryna Warshawsky, Doug Sider, Brian Schwartz, Mark P Nelder
To determine the Ontario-specific risk of local and travel-related Zika virus transmission in the context of a public health emergency of international concern, Public Health Ontario (PHO) completed a rapid risk assessment (RRA) on January 29, 2016, using a newly developed RRA guidance tool. The RRA concluded that risk of local mosquito-borne transmission was low, with a high risk of imported cases through travel. The RRA was updated 3 times based on predetermined triggers. An independent evaluation assessed both the application of the RRA guidance tool (process evaluation) and the usefulness of the RRA (outcome evaluation)...
May 2017: Health Security
https://www.readbyqxmd.com/read/28633961/full-genome-amplification-and-sequencing-of-zika-viruses-using-a-targeted-amplification-approach
#16
Mariana Leguia, Cristhopher D Cruz, Vidal Felices, Armando Torre, Gilda Troncos, Victoria Espejo, Carolina Guevara, Christopher Mores
We have developed methods for full-genome sequencing of Zika viruses (ZIKVs) based on a targeted amplification approach. We used alignments of publicly available complete genome data to design a primer set that selectively amplifies ZIKVs. The approach includes amplification strategies for templates present at both high- and low-copy number, and PCR cycling conditions that have been normalized across genome fragments in order to streamline laboratory handling. Abundant templates can be amplified using a strategy that uses 6 overlapping amplicons to cover the complete viral genome, whereas scarce templates can be amplified using a strategy that uses 11 overlapping amplicons of smaller size...
June 17, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28633549/an-update-on-zika-vaccine-developments
#17
Anna Durbin, Annelies Wilder-Smith
The devastating consequences of congenital Zika virus (ZIKV) infection led to a global response directed toward a better understanding of the epidemiology and pathogenesis of ZIKV and to efforts at vaccine development. As a result, there are currently 45 ZIKV vaccine candidates in development. Areas covered: Both traditional (purified inactivated, live attenuated, viral-vectored, recombinant sub-unit) and novel (DNA, self-replicating RNA, mRNA) vaccine platforms are being utilized. For emergency use, vaccines that are appropriate for women of child-bearing age (including pregnant women) are being developed...
June 21, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28632838/-infecci%C3%A3-n-por-el-virus-zika-en-el-embarazo-y-su-impacto
#18
Beuy Joob, Viroj Wiwanitkit
No abstract text is available yet for this article.
April 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28632511/zika-virus-a-cause-of-concern-in-transplantation
#19
Marilyn E Levi
PURPOSE OF REVIEW: Worldwide, the number of countries reporting Zika virus (ZKV) infection continues to increase. Although 80% of cases are asymptomatic, ZKV has been identified as a neurotropic virus associated with congenital microcephaly, Guillain-Barre' syndrome, and meningoencephalitis. Until recently, infection in transplant recipients has not been identified. This study will review the existing literature on ZKV infection, laboratory testing, and management in transplant recipients...
June 16, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28631169/zika-virus-infection-in-vietnam-current-epidemic-strain-origin-spreading-risk-and-perspective
#20
REVIEW
Dinh-Toi Chu, Vo Truong Nhu Ngoc, Yang Tao
Zika virus infection and its associated microcephaly have being receiving global concern. This infection has spread widely since the first outbreak was recorded in Africa in 1952. Now, it has been reported in over 70 countries on five continents including Africa, North and South America, Asia, and Europe. Vietnam is one of the most recent countries which had cases of Zika virus infection at the end of 2016. This country has also reported the first case of a microcephaly-born baby which was probably linked to Zika virus infection...
June 19, 2017: European Journal of Clinical Microbiology & Infectious Diseases
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