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lancet antiphospholipid syndrome

K Malícková, P Sandová, I Janatková
The Lancet was the first to report the use of anticardiolipin antibody test in a group of patients at risk of recurrent arterial and/or venous thrombosis and recurrent pregnancy losses, 23 years ago. The condition characterized by specific clinical and laboratory signs and initially called the anticardiolipin syndrome came to be known as the antiphospholipid syndrome (APS) when cross-reactivity of cardiolipin with other phospholipids was revealed. The study of APS still arouses controversy. Even after two decades of research, there is disagreement on the standardisation and interpretation of antiphospholipid antibody (APLA) test results...
November 2006: Epidemiologie, Mikrobiologie, Imunologie
H Bas de Laat, Ronald H W M Derksen, Philip G de Groot
From its discovery in the early 60s till the beginning of the 90s, there was not much interest in plasma protein beta2-glycoprotein I (beta2-GPI). The finding that beta2-GPI acts as an essential cofactor for the detection of antiphospholipid antibodies (aPL) tremendously increased the interest in beta2-GPI [Lancet 335 (1990) 1544; Lancet 336 (1990) 177; Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 4120]. It is now generally accepted that autoantibodies directed towards beta2-GPI are not only a serological marker but that they are involved in the pathology of the antiphospholipid syndrome (APS)...
August 2004: Clinical Immunology: the Official Journal of the Clinical Immunology Society
A A Rao, N C Ananthakrishna
Twenty patients with eclampsia were studied for the presence of anticardiolipin antibodies by the standard microflocculation test (quantitative) used in the VDRL. Four out of 20 patients (20%) were positive for anticardiolipin antibodies. Anticardiolipin antibodies which are antiphospholipid antibodies by decreasing the prostacyclin production may damage the vascular endothelium and cause thrombosis in the vessels. Hence, the presence of anticardiolipin antibody in eclampsia may have association with antiphospholipid antibody syndrome described by Harris et al...
May 1992: International Journal of Gynaecology and Obstetrics
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