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https://www.readbyqxmd.com/read/29679256/biomechanical-features-of-six-design-of-the-delta-external-fixator-for-treating-pilon-fracture-a-finite-element-study
#1
Muhammad Hanif Ramlee, Mohd Ayub Sulong, Evelyn Garcia-Nieto, Daniel Angure Penaranda, Antonio Ros Felip, Mohammed Rafiq Abdul Kadir
Pilon fractures can be caused by high-energy vertical forces which may result in long-term patient immobilization. Many experts in orthopedic surgery recommend the use of a Delta external fixator for type III Pilon fracture treatment. This device can promote immediate healing of fractured bone, minimizing the rate of complications as well as allowing early mobilization. The characteristics of different types of the Delta frame have not been demonstrated yet. By using the finite element method, this study was conducted to determine the biomechanical characteristics of six different configurations (Model 1 until Model 6)...
April 21, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29679119/the-role-of-iron-competition-in-the-antagonistic-action-of-the-rice-endophyte-streptomyces-sporocinereus-osish-2-against-the-pathogen-magnaporthe-oryzae
#2
Jiarui Zeng, Ting Xu, Lidan Cao, Chunyi Tong, Xuan Zhang, Dingyi Luo, Shuping Han, Pei Pang, Weibin Fu, Jindong Yan, Xuanming Liu, Yonghua Zhu
Rice blast caused by Magnaporthe oryzae severely impacts global rice yield stability. The rice endophyte Streptomyces sporocinereus OsiSh-2, with strong antagonistic activity towards M. oryzae, has been reported in our previous study. To decipher the model of the antagonistic action of OsiSh-2 towards M. oryzae, we compared the iron-capturing abilities of these two strains. The cultivation of OsiSh-2 and a M. oryzae strain under iron-rich and iron-starved conditions showed that M. oryzae depended more on iron supplementation for growth and development than did OsiSh-2...
April 20, 2018: Microbial Ecology
https://www.readbyqxmd.com/read/29678950/mapping-interaction-sites-on-human-chemokine-receptors-by-deep-mutational-scanning
#3
Jeremiah D Heredia, Jihye Park, Riley J Brubaker, Steven K Szymanski, Kevin S Gill, Erik Procko
Chemokine receptors CXCR4 and CCR5 regulate WBC trafficking and are engaged by the HIV-1 envelope glycoprotein gp120 during infection. We combine a selection of human CXCR4 and CCR5 libraries comprising nearly all of ∼7000 single amino acid substitutions with deep sequencing to define sequence-activity landscapes for surface expression and ligand interactions. After consideration of sequence constraints for surface expression, known interaction sites with HIV-1-blocking Abs were appropriately identified as conserved residues following library sorting for Ab binding, validating the use of deep mutational scanning to map functional interaction sites in G protein-coupled receptors...
April 20, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29678915/-ralstonia-eutropha-s-poly-3-hydroxybutyrate-phb-polymerase-phac1-and-phb-depolymerase-phaza1-are-phosphorylated-in-vivo
#4
Janina R Jüngert, Cameron Patterson, Dieter Jendrossek
In this study, we screened PHB synthase PhaC1 and PHB depolymerase PhaZa1 of Ralstonia eutropha for the presence of phosphorylated residues during the PHB accumulation and PHB degradation phase. Thr373 of PHB synthase PhaC1 was phosphorylated in the stationary growth phase but was not modified in the exponential and PHB accumulation phases. Ser35 of PHB depolymerase PhaZa1 was identified in phosphorylated form both in the exponential and in the stationary growth phase. Additional phosphosites were identified for both proteins in sample-dependent forms...
April 20, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29678860/development-defects-of-hydroxy-fatty-acid-accumulating-seed-are-reduced-by-castor-acyltransferases
#5
Daniel Lunn, Gracen A Smith, James G Wallis, John Browse
Researchers have long endeavored to produce modified fatty acids in easily managed crop plants where they are not natively found. An important step toward this goal has been biosynthesis of these valuable products in model oilseeds. The successful production of such fatty acids has revealed barriers to broad application of this technology, including low seed oil and low proportion of the introduced fatty acid. An additional barrier, rarely examined in the literature, is reduced seed vigor. Here, we analyze the impact on seedling development of transgenic production of hydroxy-fatty acids...
April 20, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29678650/femoseal%C3%A2-device-use-for-femoral-artery-closure-by-different-techniques
#6
Roberto Gabrielli, Maria Sofia Rosati, Massiliano Millarelli, Angelica Dante, Maurizio Maiorano, Aldo Musilli, Roberto Chiappa, Marco Ventura
BACKGROUND: Common femoral artery is still the most frequently site used for vascular access, mostly for peripheral arterial interventions and its puncture remains a significant source of patient's morbidity. Manual compression (MC) has been the gold standard for hemostasis after femoral catheterization until recently, but only in the last few years, vascular closure devices (VCDs) are replacing MC due to their rapid development. Nowadays also vascular surgeons are becoming familiar with VCDs...
April 17, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29678206/biliverdin-reductase-a-attenuated-gmh-induced-inflammatory-response-in-the-spleen-by-inhibiting-toll-like-receptor-4-through-enos-no-pathway
#7
Yiting Zhang, Yan Ding, Tai Lu, Yixin Zhang, Ningbo Xu, Devin W McBride, Jiping Tang, John H Zhang
BACKGROUND: Germinal matrix hemorrhage (GMH) is a common neurologic event with high morbidity and mortality in preterm infants. Spleen has been reported to play a critical role in inflammatory responses by regulating peripheral immune cells which contributes to secondary brain injury. METHODS: The current study investigated the mechanistic role of biliverdin reductase-A (BLVRA) in the splenic response and brain damage in neonates following a collagenase GMH model...
April 20, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29675629/-geriatric-trauma-center-dgu%C3%A2-evaluation-of-clinical-and-economic-parameters-a-pilot-study-in-a-german-university-hospital
#8
M Knobe, B Böttcher, M Coburn, T Friess, L C Bollheimer, H J Heppner, C J Werner, J-P Bach, M Wollgarten, S Poßelt, C Bliemel, B Bücking
BACKGROUND: Previous studies on orthogeriatric models of care suggest that there is substantial variability in how geriatric care is integrated in the patient management and the necessary intensity of geriatric involvement is questionable. OBJECTIVE: The aim of the current prospective cohort study was the clinical and economic evaluation of fragility fracture treatment pathways before and after the implementation of a geriatric trauma center in conformity with the guidelines of the German Trauma Society (DGU)...
April 19, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/29675009/genomic-structural-variations-affecting-virulence-during-clonal-expansion-of-pseudomonas-syringae-pv-actinidiae-biovar-3-in-europe
#9
Giuseppe Firrao, Emanuela Torelli, Cesare Polano, Patrizia Ferrante, Francesca Ferrini, Marta Martini, Simone Marcelletti, Marco Scortichini, Paolo Ermacora
Pseudomonas syringae pv. actinidiae (Psa) biovar 3 caused pandemic bacterial canker of Actinidia chinensis and Actinidia deliciosa since 2008. In Europe, the disease spread rapidly in the kiwifruit cultivation areas from a single introduction. In this study, we investigated the genomic diversity of Psa biovar 3 strains during the primary clonal expansion in Europe using single molecule real-time (SMRT), Illumina and Sanger sequencing technologies. We recorded evidences of frequent mobilization and loss of transposon Tn6212, large chromosome inversions, and ectopic integration of IS sequences (remarkably ISPsy31, ISPsy36, and ISPsy37)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29674149/sorption-desorption-of-sb-iii-in-different-soils-kinetics-and-effects-of-the-selective-removal-of-hydroxides-organic-matter-and-humic-substances
#10
Jining Li, Hong Hou, Masaaki Hosomi
To examine the Sb(III) retention by three soils with different properties (Ferrosol, Primosol and Isohumosol), kinetic batch experiments were carried out for Sb(III) adsorption-desorption, followed by Sb release using a sequential extraction procedure. In addition, hydroxides, organic matter, and humic substances were selectively removed by washing the soil with oxalate, sodium dithionate-citrate-bicarbonate, H2 O2 , and NaOH. The effects of removing these substances on Sb(III) retention were investigated by comparing the Sb distribution coefficients and desorption rates...
April 13, 2018: Chemosphere
https://www.readbyqxmd.com/read/29673972/microalgae-as-multi-functional-options-in-modern-agriculture-current-trends-prospects-and-challenges
#11
REVIEW
Nirmal Renuka, Abhishek Guldhe, Radha Prasanna, Poonam Singh, Faizal Bux
Algae are a group of ubiquitous photosynthetic organisms comprising eukaryotic green algae and Gram-negative prokaryotic cyanobacteria, which have immense potential as a bioresource for various industries related to biofuels, pharmaceuticals, nutraceuticals and feed. This fascinating group of organisms also has applications in modern agriculture through facilitating increased nutrient availability, maintaining the organic carbon and fertility of soil, and enhancing plant growth and crop yields, as a result of stimulation of soil microbial activity...
April 16, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29673844/nongenomic-cortisol-signaling-in-fish
#12
REVIEW
Chinmayee Das, Marwa Thraya, Mathilakath M Vijayan
Glucocorticoids are critical regulators of the cellular processes that allow animals to cope with stressors. In teleosts, cortisol is the primary circulating glucocorticoid and this hormone mediates a suite of physiological responses, most importantly energy substrate mobilization that is essential for acute stress adaptation. Cortisol signaling has been extensively studied and the majority of work has been on the activation of the glucocorticoid receptor (GR), a ligand-bound transcription factor, and the associated downstream transcriptional and protein responses...
April 16, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29673816/technical-nuances-of-exposing-rat-common-carotid-arteries-for-practicing-microsurgical-anastomosis
#13
Ali Tayebi Meybodi, Joseph Aklinski, Sirin Gandhi, Mark C Preul, Michael T Lawton
BACKGROUND: Animal models are commonly used in training protocols for microsurgical vascular anastomosis. Rat common carotid arteries (CCA) are frequently used for this purpose. Much attention has been paid to the technical details of various anastomosis configurations using these arteries. However, technical nuances of exposing rat CCA have been understudied. The purpose of this study is to describe nuances of technique for safely and efficiently exposing rat CCA in preparation for a vascular anastomosis METHODS: Bilateral CCAs were exposed and prepared for anastomosis in 10 anesthetized Sprague-Dawley rats through a midline cervical incision...
April 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29673697/adrenocortical-development-lessons-from-mouse-models
#14
Typhanie Dumontet, Isabelle Sahut-Barnola, Amandine Septier, Nathanaëlle Montanier, Ingrid Plotton, Florence Roucher-Boulez, Véronique Ducros, Anne-Marie Lefrançois-Martinez, Jean-Christophe Pointud, Mohamad Zubair, Ken-Ichirou Morohashi, David T Breault, Pierre Val, Antoine Martinez
The adrenocortical gland undergoes structural and functional remodelling in the fetal and postnatal periods. After birth, the fetal zone of the gland undergoes rapid involution in favor of the definitive cortex, which reaches maturity with the emergence of the zona reticularis(zR) at the adrenarche. The mechanisms underlying the adrenarche, the process leading to pre-puberty elevation of plasma androgens in higher primates, remain unknown, largely due to lack of any experimental model. By following up fetal and definitive cortex cell lines in mice, we showed that activation of protein kinase A (PKA) signaling mainly impacts the adult cortex by stimulating centripetal regeneration, with differentiation and then conversion of the zona fasciculata into a functional zR...
April 16, 2018: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29672843/challenges-faced-in-rural-hospitals-the-experiences-of-nurse-managers-in-uganda
#15
T A Kakyo, L D Xiao
AIM: The aim of this study was to understand nurse ward managers perceived challenges in the rural healthcare setting in Uganda. BACKGROUND: The health workforce, essential medicines and equipment and political unrest are the main factors affecting the international community in addressing the hefty disease burden in World Health Organization African regions. Nurse ward managers have an important role to play to mitigate these factors in health facilities in these regions through leadership, supervision and support for staff...
April 19, 2018: International Nursing Review
https://www.readbyqxmd.com/read/29672557/simulating-direct-shear-tests-with-the-bullet-physics-library-a-validation-study
#16
Ehsan Izadi, Adam Bezuijen
This study focuses on the possible uses of physics engines, and more specifically the Bullet physics library, to simulate granular systems. Physics engines are employed extensively in the video gaming, animation and movie industries to create physically plausible scenes. They are designed to deliver a fast, stable, and optimal simulation of certain systems such as rigid bodies, soft bodies and fluids. This study focuses exclusively on simulating granular media in the context of rigid body dynamics with the Bullet physics library...
2018: PloS One
https://www.readbyqxmd.com/read/29672400/enhanced-recovery-after-surgery-eras-pathway-in-esophagectomy-is-a-reasonable-prediction-of-hospital-stay-possible
#17
Paolo Parise, Carlo Ferrari, Andrea Cossu, Francesco Puccetti, Ugo Elmore, Stefano De Pascale, Leonardo Garutti, Uberto Romario Fumagalli, Mariaclelia Stefania Di Serio, Riccardo Rosati
OBJECTIVE: To assess whether perioperative variables or deviation from enhanced recovery after surgery (ERAS) items could be associated with delayed discharge after esophagectomy, and to convert them into a scoring system to predict it. SUMMARY BACKGROUND DATA: ERAS perioperative pathways have been recently applied to esophageal resections. However, low adherence to ERAS items and high rates of protocol deviations are often reported. METHODS: All patients who underwent esophagectomy between April 2012 and March 2017 were managed with a standardized perioperative pathway according to ERAS principles...
April 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29672111/-the-impact-of-uncertain-threat-on-affective-bias-individual-differences-in-response-to-ambiguity-correction
#18
(no author information available yet)
Reports an error in "The impact of uncertain threat on affective bias: Individual differences in response to ambiguity" by Maital Neta, Julie Cantelon, Zachary Haga, Caroline R. Mahoney, Holly A. Taylor and F. Caroline Davis ( Emotion , 2017[Dec], Vol 17[8], 1137-1143). In this article, the copyright attribution was incorrectly listed under the Creative Commons CC-BY license due to production-related error. The correct copyright should be "In the public domain." The online version of this article has been corrected...
April 2018: Emotion
https://www.readbyqxmd.com/read/29671490/common-running-injuries-evaluation-and-management
#19
Michael J Arnold, Aaron L Moody
Running is a common form of exercise but predisposes athletes to several running-related injuries. Most running injuries are due to overuse and respond to conservative treatment. Tendinopathies in the patellar, Achilles, and hamstring tendons are common, and are primarily treated with eccentric exercise. Iliotibial band syndrome and patellofemoral pain syndrome are less common than patellar tendinopathy and are treated by strengthening exercises for the core and legs in addition to flexibility exercises. Acute hamstring strains and medial tibial stress syndrome require a period of relative rest, followed by stretching and graded return to activity...
April 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29671022/-the-minimally-invasive-chevron-and-akin-osteotomy-mica
#20
REVIEW
Sebastian Altenberger, Stefanie Kriegelstein, Oliver Gottschalk, Florian Dreyer, Alexander Mehlhorn, Anke Röser, Markus Walther
OBJECTIVE: Percutaneous correction of a hallux valgus deformity with or without transfer metatarsalgia. INDICATIONS: Hallux valgus deformity up to 20° intermetatarsal angle, without instability of the first tarsometatarsal joint. CONTRAINDICATIONS: Symptomatic arthritis of the first metatarsophalangeal joint, as well as instability of the first tarsometatarsal joint. SURGICAL TECHNIQUE: Percutaneous performed osteotomy of the distal metatarsal 1 in combination with a medial closing wedge osteotomy of the proximal phalanx of the first toe...
April 18, 2018: Operative Orthopädie und Traumatologie
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