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https://www.readbyqxmd.com/read/29458123/osteocyte-regulation-of-bone-and-blood
#1
REVIEW
Paola Divieti Pajevic, Daniela S Krause
This past decade has witnessed a renewed interest in the function and biology of matrix-embedded osteocytes and these cells have emerged as master regulators of bone homeostasis. They secrete two very powerful proteins, sclerostin, a Wnt-inhibitor, that suppresses bone formation, and receptor-activator of NF-kB ligand (RANKL), a cytokine required for osteoclastogenesis. Neutralizing antibodies against these proteins are currently used for the treatment of osteoporosis. Recent studies however, ascribed yet another function to osteocytes: the control of hematopoiesis and the HSPC niche, directly and through secreted factors...
February 16, 2018: Bone
https://www.readbyqxmd.com/read/29458070/the-epigenetic-alterations-of-endogenous-retroelements-in-aging
#2
REVIEW
Maurizio Cardelli
Endogenous retroelements, transposons that mobilize through RNA intermediates, include some of the most abundant repetitive sequences of the human genome, such as Alu and LINE-1 sequences, and human endogenous retroviruses. Recent discoveries demonstrate that these mobile genetic elements not only act as intragenomic parasites, but also exert regulatory roles in living cells. The risk of genomic instability represented by endogenous retroelements is normally counteracted by a series of epigenetic control mechanisms which include, among the most important, CpG DNA methylation...
February 16, 2018: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29456832/interleukin-25-and-eosinophils-progenitor-cell-mobilization-in-allergic-asthma
#3
Wei Tang, Steven G Smith, Wei Du, Akash Gugilla, Juan Du, John Paul Oliveria, Karen Howie, Brittany M Salter, Gail M Gauvreau, Paul M O'Byrne, Roma Sehmi
Background: Eosinophil-lineage committed progenitor cells (EoP) migrate from the bone marrow and differentiate locally to provide an ongoing source of mature eosinophils in asthmatic inflammatory responses in the airways. Sputum levels of EoP are increased in asthmatics compared to normal controls suggesting an exaggerated eosinophilopoietic environment in the airways. Understanding what factors promote EoP traffic to the airways is important to understand the diathesis of asthma pathology...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29456346/the-effects-of-posterior-talar-glide-and-dorsiflexion-of-the-ankle-plus-mobilization-with-movement-on-balance-and-gait-function-in-patient-with-chronic-stroke-a-randomized-controlled-trial
#4
Sang-Lim Kim, Byoung-Hee Lee
Background: This study was to evaluate the effects of weight-bearing-based mobilization with movement (WBBMWM) on balance and gait in stroke patients. Methods: Thirty stroke patients participated in this study. All individuals were randomly assigned to either WBMWM group ( n = 15) or weight-bearing with placebo mobilization with movement group (control, n = 15). Individuals in the WBMWM group were trained for 10 glides of 5 sets a day, 5 times a week during 4 weeks...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29455909/elevated-tissue-sodium-deposition-in-patients-with-type-2-diabetes-on-hemodialysis-detected-by-23-na-magnetic-resonance-imaging
#5
Christoph Kopp, Peter Linz, Carolin Maier, Peter Wabel, Matthias Hammon, Armin M Nagel, Daniela Rosenhauer, Stephan Horn, Michael Uder, Friedrich C Luft, Jens Titze, Anke Dahlmann
Long-term elevated blood sugar levels result in tissue matrix compositional changes in patients with diabetes mellitus type 2 (T2DM). We hypothesized that hemodialysis patients with T2DM might accumulate more tissue sodium than control hemodialysis patients. To test this,23 Na magnetic resonance imaging (23 Na MRI) was used to estimate sodium in skin and muscle tissue in hemodialysis patients with or without T2DM. Muscle fat content was estimated by1 H MRI and tissue sodium content by23 Na MRI pre- and post-hemodialysis in ten hemodialysis patients with T2DM and in 30 matched control hemodialysis patients...
February 15, 2018: Kidney International
https://www.readbyqxmd.com/read/29455499/-lateral-closing-wedge-osteotomy-and-modified-cross-pinning-with-external-tension-band-fixation-in-the-treatment-of-cubitus-varus-deformity-in-childrenlateral-closing-wedge-osteotomy-and-modified-cross-pinning-with-external-tension-band-fixation-in-the-treatment
#6
Chuan Zhang, Zuo-Jun Zhang, Lei Wang, Zhong-Xiao Chang, Lin-Ping Yang, Ming Zhao, Xing-Xing Li, Rui-Ping Feng, Guo-Jie Wang, Xiao-Bo Duan
OBJECTIVE: To explore the therapeutic effects of distal humeral lateral closing wedge osteotomy followed by modified pinning combined with external tension band fixation in the treatment of cubitus varus deformity in children. METHODS: Total 26 adult patients with cubitus varus deformity were treated by operation from March 2011 to June 2015, 15 patients were boys and the other 11 patients were girls, ranging in age from 4 to 13 years, with an average of 7.8 years...
August 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29455009/protecting-an-adult-identity-a-grounded-theory-of-supportive-care-for-young-adults-recently-diagnosed-with-cancer
#7
Louise Soanes, Faith Gibson
BACKGROUND: For adolescents and young adults living in high-income countries cancer remains the most common disease-related death. Increasing survival rates and projected longevity are positive outcomes, although long-term consequences of cancer and/or its treatment will likely increase the global burden of cancer. In low and middle-income countries the impact and needs of young adults with cancer are largely unknown and require further attention. However, universal studies have revealed that cancer-related needs for this group are multifactorial, complex and largely unmet...
January 31, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29454211/seasonality-water-use-and-community-management-of-water-systems-in-rural-settings-qualitative-evidence-from-ghana-kenya-and-zambia
#8
Emma Kelly, Katherine F Shields, Ryan Cronk, Kristen Lee, Nikki Behnke, Tori Klug, Jamie Bartram
The sustainability of rural, community-managed water systems in sub-Saharan Africa depends in part on the ability of local water committees to repair breakdowns and carry out the operation and maintenance (O&M) of the system. Much of sub-Saharan Africa has two distinct seasons that affect the availability of water sources and how people use water. Little is known about how seasonality affects water system management. This qualitative study is based on 320 interviews and focus group discussions and examines the effects of season on community water use and management in Ghana, Kenya and Zambia...
February 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29453458/il-2-inducible-kinase-itk-is-critical-for-hiv-1-infection-of-jurkat-t-cells
#9
Anika Hain, Melanie Krämer, René M Linka, Saeideh Nakhaei-Rad, Mohammad Reza Ahmadian, Dieter Häussinger, Arndt Borkhardt, Carsten Münk
Successful replication of Human immunodeficiency virus (HIV)-1 depends on the expression of various cellular host factors, such as the interleukin-2 inducible T-cell kinase (ITK), a member of the protein family of TEC-tyrosine kinases. ITK is selectively expressed in T-cells and coordinates signaling pathways downstream of the T-cell receptor and chemokine receptors, including PLC-1 activation, Ca 2+ -release, transcription factor mobilization, and actin rearrangements. The exact role of ITK during HIV-1 infection is still unknown...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453317/histone-h3-3k27m-mobilizes-multiple-cancer-testis-ct-antigens-in-pediatric-glioma
#10
Houliang Deng, Jianming Zeng, Ting Zhang, Longcai Gong, Hongjie Zhang, Edwin Cheung, Chris Jones, Gang Li
Lysine to Methionine mutations at position 27 (K27M) in the histone H3 (H3.3 and H3.1) are highly prevalent in pediatric high-grade gliomas (HGG) that arise in the midline of the central nervous system. H3K27M perturbs the activity of polycomb repressor complex 2 (PRC2) and correlates with DNA hypomethylation; however, the pathways whereby H3K27M drive the development of pediatric HGG remain poorly understood. To understand the mechanism of pediatric HGG development driven by H3.3K27M and discover potential therapeutic targets or biomarkers, we established pediatric glioma cell model systems harboring H3...
February 16, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29453251/a-novel-adipokine-fam19a5-inhibits-postinjury-neointima-formation-through-sphingosine-1-phosphate-receptor-2
#11
Yingbao Wang, Dixin Chen, Yan Zhang, Pingzhang Wang, Can Zheng, Songyang Zhang, Bing Yu, Lu Zhang, Guizhen Zhao, Baihui Ma, Zeyu Cai, Nan Xie, Shiyang Huang, Ziyi Liu, Xiaoning Mo, Youfei Guan, Xian Wang, Yi Fu, Dalong Ma, Ying Wang, Wei Kong
Background -Obesity plays crucial roles in the development of cardiovascular diseases (CVDs). However, the mechanisms that link obesity and CVDs remain elusive. Compelling evidence indicates that adipokines play an important role in obesity-related CVDs. Here, we found a new adipokine named family with sequence similarity 19, member A5 (FAM19A5), a protein with unknown function that was predicted to be distantly related to the CC-chemokine family. We aimed to test whether adipose-derived FAM19A5 regulates vascular pathology upon injury...
February 16, 2018: Circulation
https://www.readbyqxmd.com/read/29451881/population-based-coverage-survey-results-following-the-mass-drug-administration-of-azithromycin-for-the-treatment-of-trachoma-in-amhara-ethiopia
#12
Tigist Astale, Eshetu Sata, Mulat Zerihun, Andrew W Nute, Aisha E P Stewart, Demelash Gessesse, Gedefaw Ayenew, Berhanu Melak, Melsew Chanyalew, Zerihun Tadesse, E Kelly Callahan, Scott D Nash
BACKGROUND: Trachoma is the leading infectious cause of blindness worldwide. In communities where the district level prevalence of trachomatous inflammation-follicular among children ages 1-9 years is ≥5%, WHO recommends annual mass drug administration (MDA) of antibiotics with the aim of at least 80% coverage. Population-based post-MDA coverage surveys are essential to understand the effectiveness of MDA programs, yet published reports from trachoma programs are rare. METHODS: In the Amhara region of Ethiopia, a population-based MDA coverage survey was conducted 3 weeks following the 2016 MDA to estimate the zonal prevalence of self-reported drug coverage in all 10 administrative zones...
February 16, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29450751/left-lobe-mobilization-strategy-of-right-sided-major-hepatectomy-for-treatment-of-a-tumor-causing-severe-inferior-vena-cava-compression-a-novel-strategy-using-the-modified-liver-hanging-maneuver
#13
Kenichiro Araki, Norio Kubo, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Hiroyuki Kuwano, Ken Shirabe
BACKGROUND: Massive bleeding during major hepatectomy is associated with greater mortality and morbidity.1 Our previous study shows that inferior vena cava (IVC) compression by tumor and an anterior approach without the liver-hanging maneuver (LHM) are risk factors for massive bleeding.2 The LHM is useful for controlling bleeding in deeper parenchymal transection planes.3 However, severe compression of the IVC by tumor makes it difficult to insert a hanging tape.4 The study shows a novel modified LHM strategy for severe IVC compression to minimize intraoperative bleeding...
February 14, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29450630/outermost-layer-oriented-medial-approach-for-infrapyloric-nodal-dissection-in-laparoscopic-distal-gastrectomy
#14
Susumu Shibasaki, Koichi Suda, Masaya Nakauchi, Tetsuya Nakamura, Shinichi Kadoya, Kenji Kikuchi, Kazuki Inaba, Ichiro Uyama
BACKGROUND: Based on our experience of suprapancreatic nodal dissection in laparoscopic gastrectomy, we developed an outermost layer-oriented medial approach for infrapyloric nodal dissection. The objective of this single-institution retrospective study was to determine the feasibility, safety, and reproducibility of this novel and unique dissection procedure. METHODS: This approach can be performed in the same manner as suprapancreatic nodal dissection but by replacing the left gastric artery with the right gastroepiploic artery (RGEA), the common hepatic artery with the anterior superior pancreaticoduodenal artery (ASPDA), and the splenic artery with the gastroduodenal artery...
February 15, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29449851/divergent-n-deficiency-dependent-senescence-and-transcriptome-response-in-developmentally-old-and-young-brassica-napus-leaves
#15
Vajiheh Safavi-Rizi, Jürgen Franzaring, Andreas Fangmeier, Reinhard Kunze
In the spring oilseed rape (OSR) cultivar 'Mozart' grown under optimal N supply (N O ) or mild N deficiency (N L ) the transcriptome changes associated with progressing age until early senescence in developmentally old lower canopy leaves (leaf #4) and younger higher canopy leaves (leaf #8) were investigated. Twelve weeks old N O and N L plants appeared phenotypically and transcriptomically identical, but thereafter distinct nutrition-dependent differences in gene expression patterns in lower and upper canopy leaves emerged...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29449768/grade-iv-inferior-glenohumeral-mobilization-does-not-immediately-alter-shoulder-and-scapular-muscle-activity-a-repeated-measures-study-in-asymptomatic-individuals
#16
Daniel Cury Ribeiro, Ashleigh Day, Clark R Dickerson
Objectives: To assess: (1) the presence of any carry-over effect between interventions; (2) the immediate effects of inferior shoulder mobilization on shoulder and scapular muscle activity; and (3) to compare muscle activity response between the control and mobilization conditions. Repeated measures, cross-over, pre-post intervention study with sample of convenience. Methods: Twenty-two asymptomatic individuals performed 10 repetitions of shoulder abduction before and after the control and mobilization, with a dosage of three sets of 30-s duration, with grade-IV...
December 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/29449767/novel-treatment-of-lateral-ankle-sprains-using-the-mulligan-concept-an-exploratory-case-series-analysis
#17
Robinetta Hudson, Russell T Baker, James May, Don Reordan, Alan Nasypany
Objective: The purpose of this study was to examine the effect of the Mulligan Concept (MC) Mobilization with movement (MWM) in the treatment of clinically diagnosed acute lateral ankle sprains in competitive athletes. Methods: A prospective case series of 5 adolescent patients, ages ranging from 14 to 18 years (mean = 15.8 ± 1.64), that suffered an acute lateral ankle sprain (LAS). Patients were treated with the MC lateral ankle MWM. Mobilization was directed at the distal fibula or, using a modified MWM, 2-3 inches proximal to the distal fibula...
December 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/29449580/botulinum-neurotoxin-encoding-plasmids-can-be-conjugatively-transferred-to-diverse-clostridial-strains
#18
Erin M Nawrocki, Marite Bradshaw, Eric A Johnson
Most Group I Clostridium botulinum strains harbor botulinum neurotoxin (bont) genes on their chromosome, while some carry these genes (including bont/a, bont/b, and bont/f) on large plasmids. Prior work in our laboratory demonstrated that Group I BoNT plasmids were mobilized to C. botulinum recipient strains containing the Tn916 transposon. Here, we show that Tn916 is nonessential for plasmid transfer. Relying on an auxotrophic donor phenotype and a plasmid-borne selectable marker, we observed the transfer of pCLJ, a 270 kb plasmid harboring two bont genes, from its host strain to various clostridia...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29449114/role-of-rain-intensity-and-soil-colloids-in-the-retention-of-surfactant-stabilized-silver-nanoparticles-in-soil
#19
Joanna Makselon, Nina Siebers, Florian Meier, Harry Vereecken, Erwin Klumpp
Undisturbed outdoor lysimeters containing arable loamy sand soil were used to examine the influence of either heavy rain events (high frequency of high rain intensity), steady rain (continuous rainfall of low rain intensity), and natural rainfall on the transport and retention of surfactant-stabilized silver nanoparticles (AgNP). In addition, the AgNP-soil associations within the A p horizon were analyzed by means of particle-size fractionation, asymmetrical flow field-flow fractionation coupled with UV/Vis-detection and inductively coupled plasma mass spectrometer (AF4-UV/Vis-ICP-MS), and transmission electron microscopy coupled to an energy-dispersive X-ray (TEM-EDX) analyzer...
February 12, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29448387/pressure-evolution-and-deformation-of-confined-granular-media-during-pneumatic-fracturing
#20
Fredrik K Eriksen, Renaud Toussaint, Antoine Léo Turquet, Knut J Måløy, Eirik G Flekkøy
By means of digital image correlation, we experimentally characterize the deformation of a dry granular medium confined inside a Hele-Shaw cell due to air injection at a constant overpressure high enough to deform it (from 50 to 250 kPa). Air injection at these overpressures leads to the formation of so-called pneumatic fractures, i.e., channels empty of beads, and we discuss the typical deformations of the medium surrounding these structures. In addition we simulate the diffusion of the fluid overpressure into the medium, comparing it with the Laplacian solution over time and relating pressure gradients with corresponding granular displacements...
January 2018: Physical Review. E
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