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https://www.readbyqxmd.com/read/29050394/cortical-neurons-and-networks-are-dormant-but-fully-responsive-during-isoelectric-brain-state
#1
Tristan Altwegg-Boussac, Adrien E Schramm, Jimena Ballestero, Fanny Grosselin, Mario Chavez, Sarah Lecas, Michel Baulac, Lionel Naccache, Sophie Demeret, Vincent Navarro, Séverine Mahon, Stéphane Charpier
A continuous isoelectric electroencephalogram reflects an interruption of endogenously-generated activity in cortical networks and systematically results in a complete dissolution of conscious processes. This electro-cerebral inactivity occurs during various brain disorders, including hypothermia, drug intoxication, long-lasting anoxia and brain trauma. It can also be induced in a therapeutic context, following the administration of high doses of barbiturate-derived compounds, to interrupt a hyper-refractory status epilepticus...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29049888/closing-in-behavior-compensation-or-attraction
#2
Elisabetta Ambron, Nicoletta Beschin, Chiara Cerrone, Sergio Della Sala
OBJECTIVE: Closing-in behavior (CIB) defines the abnormal misplacement of the copy performance, positioned very closed to or on the top of the model. This symptom is observed in graphic copying by patients suffering from different neurological diseases, most commonly dementia. The cognitive origins of this behavior are still a matter of investigation, and research of the last 10 years has been focused on exploring 2 main accounts of CIB, the compensation and the attraction hypotheses, providing evidence in both directions...
October 19, 2017: Neuropsychology
https://www.readbyqxmd.com/read/29049784/hormonal-manipulation-after-surgery-for-catamenial-pneumothorax
#3
Megan Garner, Eltayeb Ahmed, Sarah Gatiss, Douglas West
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was whether hormonal manipulation with gonadotrophin-releasing hormone analogues reduces the risk of recurrent catamenial pneumothorax after surgery, compared with surgery alone. Altogether 819 papers were found using the reported search, of which 7 represented the best evidence to answer the clinical question. The authors, date, journal, country of publication, study type, level of evidence, patient group studied, relevant outcomes and results of these papers are tabulated...
September 28, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049663/surgical-treatment-of-left-ventricular-echinococcosis-through-the-heartport-technique
#4
Alfonso Agnino, Alberto Maria Lanzone, Giuseppe Spira, Amedeo Anselmi
Echinococcal lesions rarely involve the heart; nonetheless, echinococcal cysts of the left ventricular myocardium often demand surgical treatment due to the risk of rupture and anaphylaxis. Herein, an echinococcal cyst of the anteroapical left ventricular wall was managed through small left anterior thoracotomy; repair was achieved under cardioplegic arrest (endoaortic balloon occlusion) with an uneventful course. We discuss the usefulness of such a less invasive approach for the depicted lesion (minimized manipulation of the heart and reduced surgical aggressiveness) and for other lesions involving the apical/lateral LV region...
September 8, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049621/autonomic-nervous-system-responses-to-hearing-related-demand-and-evaluative-threat
#5
Carol L Mackersie, Lucia Kearney
Purpose: This paper consists of 2 parts. The purpose of Part 1 was to review the potential influence of internal (person-related) factors on listening effort. The purpose of Part 2 was to present, in support of Part 1, preliminary data illustrating the interactive effects of an external factor (task demand) and an internal factor (evaluative threat) on autonomic nervous system measures. Method: For Part 1, we provided a brief narrative review of motivation and stress as modulators of listening effort...
October 12, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/29049594/the-perceptual-dimensions-of-natural-dynamic-flow
#6
Yaniv Morgenstern, Daniel J Kersten
We measured perceptual judgments of category, material attributes, affordances, and similarity to investigate the perceptual dimensions underlying the visual representation of a broad class of natural dynamic flows (sea waves, smoke, and windblown foliage). The dynamic flows were looped 3-s movies windowed with circular apertures of two sizes to manipulate the level of spatial context. In low levels of spatial context (smaller apertures), human observers' judgments of material attributes and affordances were inaccurate, with estimates biased toward assumptions that the flows resulted from objects that were rigid, "pick-up-able," and not penetrable...
October 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/29049371/combining-epidemiology-with-basic-biology-of-sand-flies-parasites-and-hosts-to-inform-leishmaniasis-transmission-dynamics-and-control
#7
REVIEW
Orin Courtenay, Nathan C Peters, Matthew E Rogers, Caryn Bern
Quantitation of the nonlinear heterogeneities in Leishmania parasites, sand fly vectors, and mammalian host relationships provides insights to better understand leishmanial transmission epidemiology towards improving its control. The parasite manipulates the sand fly via production of promastigote secretory gel (PSG), leading to the "blocked sand fly" phenotype, persistent feeding attempts, and feeding on multiple hosts. PSG is injected into the mammalian host with the parasite and promotes the establishment of infection...
October 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29049364/correction-native-phytoremediation-potential-of-urtica-dioica-for-removal-of-pcbs-and-heavy-metals-can-be-improved-by-genetic-manipulations-using-constitutive-camv-35s-promoter
#8
Jitka Viktorova, Zuzana Jandova, Michaela Madlenakova, Petra Prouzova, Vilem Bartunek, Blanka Vrchotova, Petra Lovecka, Lucie Musilova, Tomas Macek
[This corrects the article DOI: 10.1371/journal.pone.0167927.].
2017: PloS One
https://www.readbyqxmd.com/read/29049360/the-bacterial-virulence-factor-caga-induces-microbial-dysbiosis-that-contributes-to-excessive-epithelial-cell-proliferation-in-the-drosophila-gut
#9
Tiffani Alvey Jones, Diane Z Hernandez, Zoë C Wong, Anica M Wandler, Karen Guillemin
Gut microbiota facilitate many aspects of human health and development, but dysbiotic microbiota can promote hyperplasia and inflammation and contribute to human diseases such as cancer. Human patients infected with the gastric cancer-causing bacterium Helicobacter pylori have altered microbiota; however, whether dysbiosis contributes to disease in this case is unknown. Many H. pylori human disease phenotypes are associated with a potent virulence protein, CagA, which is translocated into host epithelial cells where it alters cell polarity and manipulates host-signaling pathways to promote disease...
October 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29049148/skull-base-neuroendoscopic-training-model-using-a-fibrous-injectable-tumor-polymer-and-the-nico-myriad
#10
Filippo Gagliardi, Anthony M Chau, Pietro Mortini, Anthony J Caputy, Cristian Gragnaniello
The Myriad is an innovative, high precision tool for tumor resection, designed to work within narrow endoscopic corridors. Due to its application in technically demanding situations, the learning curve associated with its use might be extremely challenging and time-consuming.The authors describe the application of an already validated training model, the skull base injectable tumor model (ITM), to allow trainees to practice with the use of the Myriad during endoscopic skull base procedures.A formalin embalmed cadaveric head was used for technical assessment...
October 18, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29049074/physiology-and-role-of-intraocular-pressure-in-contemporary-anesthesia
#11
Dermot J Kelly, Sinéad M Farrell
More than 26 million Americans suffer with cataracts, and with 3.6 million cataract extractions performed annually in the United States, it is the most common surgical procedure. The integrity of the delicate structures of the eye that mediate vision is dependent on the intraocular pressure (IOP). Yet, IOP acts to compress the vessels within the globe-akin to a Starling resistor-and is a key component that determines the ocular perfusion pressure, defined as the difference between arterial pressure and IOP...
October 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29049037/fractures-and-the-gut-microbiome
#12
Tara McGinty, Paddy W G Mallon
PURPOSE OF REVIEW: The role of the gut microbiome in the pathogenesis of several inflammatory, non-AIDS comorbidities, such as cardiovascular disease, cognitive impairment and liver disease has become a focus of recent research. Low bone mineral density (BMD) and increased fracture incidence in people living with HIV (PLWH) is also widely reported, however, the relationship between alterations in the gut microbiome and bone disease in PLWH has not been previously reviewed. RECENT FINDINGS: Murine models that manipulate the gut microbiome, either through breeding of 'germ-free' mice or antibiotic-depleted gut microbiome, show differences in bone mineral density and bone mass in those with altered gut microbiome...
October 18, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29049035/optical-properties-of-graphene-nanocones-under-electric-and-magnetic-fields
#13
P Ulloa, M Pacheco, A Latgé
Here we present a theoretical study of the optical properties of graphene nanocones tuned by external electric and magnetic fields. We investigate the effects of the size and topology of the carbon nanostructures on the density of states and on the electro- and magneto-absorption of linearly polarized electromagnetic radiation in different nanocone geometries. We find that the electric field induces changes in the electric charge distribution mainly at the cone edges. In the infrared range the absorption coefficient shows a peculiar dependence on the electric field (magnitude and direction) and on the photon polarization for all investigated structures...
October 19, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29048927/early-origins-of-asthma-role-of-microbial-dysbiosis-and-metabolic-dysfunction
#14
Fernando D Martinez, Stefano Guerra
Asthma is a developmental disease that affects airway growth and is characterized by inappropriate responses to a variety of environmental stimuli. Recent advances point to two altered early life pathways as major determinants of asthma risk. In the "microbial" pathway, pre- and post-natal exposures to microbiota-loaded farm environments block gene-virus interactions (e.g., interactions between risk alleles in chromosome 17q21 and lower respiratory illnesses [LRI] by rhinovirus) that are associated with asthma development...
October 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29048555/an-architecture-for-genomics-analysis-in-a-clinical-setting-using-galaxy-and-docker
#15
W Digan, H Countouris, M Barritault, D Baudoin, P Laurent-Puig, H Blons, A Burgun, B Rance
Background: Next Generation Sequencing is used on a daily basis to perform molecular analysis to determine subtypes of disease (e.g., in cancer) and to assist in the selection of the optimal treatment. Clinical bioinformatics handles the manipulation of the data generated by the sequencer, from the generation to the analysis and interpretation. Reproducibility and traceability are crucial issues in a clinical setting. Results: We have designed an approach based on the Docker container technology and Galaxy, the popular bioinformatics analysis support open-source software...
October 18, 2017: GigaScience
https://www.readbyqxmd.com/read/29048474/transinnominate-approach-for-transcatheter-aortic-valve-replacement-single-centre-experience-of-minimally-invasive-alternative-access
#16
Luigi Pirelli, Jacob S Scheinerman, Derek R Brinster, Nirav C Patel, Alaeldin Eltom, Jonathan M Hemli, Chad A Kliger
OBJECTIVES: Iliofemoral arteries have been the preferred access for transcatheter aortic valve replacement (TAVR). When these arteries are too small, calcified or tortuous, an alternative access must be considered. Transinnominate (TI) access is an extrathoracic approach that does not require manipulation of major neurovascular structures or the apex. The aim of this study is to evaluate the efficacy and safety of TI TAVR as an alternative access in patients with severe aortic stenosis not amenable to a transfemoral approach...
October 18, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29048333/quantitative-analysis-and-predictive-engineering-of-self-rolling-of-nanomembranes-under-anisotropic-mismatch-strain
#17
Cheng Chen, Pengfei Song, Fanchao Meng, Xiao Li, Xinyu Liu, Jun Song
The present work presents a quantitative modeling framework for investigating the self-rolling of nanomembranes under different lattice mismatch strain anisotropy. The effect of transverse mismatch strain on the roll-up direction and curvature has been systematically studied employing both analytical modeling and numerical simulations. The bidirectional nature of the self-rolling of nanomembranes and the critical role of transverse strain in affecting the rolling behaviors have been demonstrated. Two fabrication strategies, i...
October 19, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29048317/non-normal-data-is-anova-still-a-valid-option
#18
María J Blanca, Rafael Alarcón, Jaume Arnau, Roser Bono, Rebecca Bendayan
BACKGROUND: The robustness of F-test to non-normality has been studied from the 1930s through to the present day. However, this extensive body of research has yielded contradictory results, there being evidence both for and against its robustness. This study provides a systematic examination of F-test robustness to violations of normality in terms of Type I error, considering a wide variety of distributions commonly found in the health and social sciences. METHOD: We conducted a Monte Carlo simulation study involving a design with three groups and several known and unknown distributions...
November 2017: Psicothema
https://www.readbyqxmd.com/read/29048286/paracoccidioidomycosis-after-highway-construction-rio-de-janeiro-brazil
#19
Antonio C Francesconi do Valle, Priscila Marques de Macedo, Rodrigo Almeida-Paes, Anselmo R Romão, Marcia Dos Santos Lazéra, Bodo Wanke
Transmission of Paracoccidioides spp. fungi to humans is usually related to manipulation of soil. Rural workers are the most affected group. We report an outbreak of paracoccidioidomycosis after deforestation and massive earth removal during construction of a highway in Rio de Janeiro, Brazil. Extensive environmental disturbances might be involved in fungal transmission.
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29048258/selection-of-implantation-sites-for-transplantation-of-encapsulated-pancreatic-islets
#20
Haitao Zhu, Wenjing Li, Zhongwei Liu, Wenliang Li, Niuniu Chen, Linlin Lu, Wei Zhang, Zhen Wang, Bo Wang, Kaili Pan, Xiaoge Zhang, Guoqiang Chen
Pancreatic islet transplantation has been validated as a valuable therapy for type 1 diabetes mellitus patients with exhausted insulin treatment. However, this therapy remains limited by the shortage of donor and the requirement of lifelong immunosuppression. Islet encapsulation, as an available bioartificial pancreas (BAP), represents a promising approach to enable protecting islet grafts without or with minimal immunosuppression and possibly expanding the donor pool. In order to develop a clinically implantable BAP, some key aspects need to be taken into accounts: encapsulation material, capsule design and implantation site...
October 19, 2017: Tissue Engineering. Part B, Reviews
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