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https://www.readbyqxmd.com/read/29913322/culture-supernatants-of-oral-cancer-cells-induce-impaired-ifn-%C3%AE-production-of-pdcs-partly-through-the-down-regulation-of-tlr-9-expression
#1
Nannan Han, Zun Zhang, Houyu Jv, Jingzhou Hu, Min Ruan, Chenping Zhang
OBJECTIVES: The aim of the present study was to investigate whether tumor-derived supernatants down-regulate the immune function of plasmacytoid dendritic cells (pDCs) in oral cancer and the potential molecular mechanisms of this effect. MATERIALS AND METHODS: Immunohistochemistry (IHC) and flow cytometry were used to detect tumor-infiltrating and peripheral blood pDCs. MTS and flow cytometry were employed to evaluate the immune response of CD4+ T cells. Real-time PCR and ELISA assays were used to identify TLR-7 and TLR-9 expression, IFN-α production and tumor-secreted soluble cytokines...
June 5, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29913247/the-use-of-visual-cues-in-gravity-judgements-on-parabolic-motion
#2
Björn Jörges, Lena Slupinski, Joan López-Moliner
Evidence suggests that humans rely on an earth gravity prior for sensory-motor tasks like catching or reaching. Even under earth-discrepant conditions, this prior biases perception and action towards assuming a gravitational downwards acceleration of 9.81 m/s2 . This can be particularly detrimental in interactions with virtual environments employing earth-discrepant gravity conditions for their visual presentation. The present study thus investigates how well humans discriminate visually presented gravities and which cues they use to extract gravity from the visual scene...
June 15, 2018: Vision Research
https://www.readbyqxmd.com/read/29913225/an-insect-nucleoside-diphosphate-kinase-ndk-functions-as-an-effector-protein-in-wheat-hessian-fly-interactions
#3
Zhuhong Wang, Jun-Qing Ge, Hang Chen, Xiaoyan Cheng, Yiqun Yang, Jun Li, R Jeff Whitworth, Ming-Shun Chen
Like pathogens, galling insects deliver effectors into plant tissues that induce gall formation. The gall midge Mayetiola destructor, also called Hessian fly, can convert a whole wheat seedling into a gall by inducing the formation of nutritive cells at the feeding site, inhibiting wheat growth, and reprogramming metabolic pathways of the attacked plants. Here we demonstrated the identification of a secreted Hessian fly protein, the nucleoside diphosphate kinase (NDK), in infested wheat plants through liquid chromatography-tandem mass spectrometry (LC-MS/MS) and western blots...
June 15, 2018: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29912757/dietary-interventions-in-liver-cirrhosis
#4
Chu Kion Yao, James Fung, Natural Hoi Sing Chu, Victoria Ping Yi Tan
Liver cirrhosis is associated with significant nutritional risks that often result in serious hepatic complications and poor survival rates. Diet is an important but underutilized aspect in the treatment modality of cirrhosis. Therefore, the aims of this review are to ascertain nutritional risks associated with its pathophysiology and to summarize existing evidence that support dietary recommendations for managing this patient population. Alterations in substrate utilization for energy production is a main feature of liver cirrhosis, resulting in increased catabolism of protein stores and a predisposition toward protein-energy malnutrition, even in the early stages of the disease...
June 16, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29912732/a-novel-biportal-full-endoscopy-technique-for-lumbar-lateral-recess-stenosis-technical-report
#5
Xinchun Liu
Full endoscopy spine surgery is one of the minimally invasive procedures for lumbar spine disease and is especially popular in East Asia. As for the interlaminar approach, lumbar recess stenosis can be manipulated through a uniportal bigger diameter working channel spinal endoscope or a smaller one, or a biportal arthroscope. Each kind of procedure has its advantages and shortcomings. Here, a novel experience in biportal interlaminar approach for lumbar recess stenosis is presented. A smaller uniportal spinal endoscope is adopted for biportal procedures rather than the arthroscope...
June 15, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29912630/less-is-more-effects-of-exhaustive-vs-minimal-emotion-labelling-on-emotion-regulation-strategy-planning
#6
Vera Vine, Emily E Bernstein, Susan Nolen-Hoeksema
Previous research suggests that labelling emotions, or describing affective states using emotion words, facilitates emotion regulation. But how much labelling promotes emotion regulation? And which emotion regulation strategies does emotion labelling promote? Drawing on cognitive theories of emotion, we predicted that labelling emotions using fewer words would be less confusing and would facilitate forms of emotion regulation requiring more cognitively demanding processing of context. Participants (N = 82) mentally immersed themselves in an emotional vignette, were randomly assigned to an exhaustive or minimal emotion labelling manipulation, and then completed an emotion regulation strategy planning task...
June 18, 2018: Cognition & Emotion
https://www.readbyqxmd.com/read/29912390/modality-specific-subpopulations-of-place-fields-coexist-in-the-hippocampus
#7
Olivia V Haas, Josephine Henke, Christian Leibold, Kay Thurley
Hippocampal place cells integrate signals from multiple sensory modalities. However, it is unclear how these different inputs are combined to generate place fields. We investigated how visual spatial cues and an animal's locomotion are integrated by CA3 place cells of Mongolian gerbils. While the animals moved on a virtual linear track, we adapted the gain between the visually projected environment and the treadmill movement. Place cells responded differently to this manipulation. In a subset, place fields were kept in accord with salient visual cues in the virtual environment or reward location, whereas in another subset, place fields were strongly influenced by locomotion...
April 18, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29912306/prevalence-and-prevention-of-oesophageal-injury-during-atrial-fibrillation-ablation-a-systematic-review-and-meta-analysis
#8
Francis J Ha, Hui-Chen Han, Prashanthan Sanders, Andrew W Teh, David O'Donnell, Omar Farouque, Han S Lim
Aims: Atrio-oesophageal fistula (AOF) is a potentially lethal complication of atrial fibrillation (AF) ablation. Many studies have evaluated the presence and prevention of endoscopically-detected oesophageal lesions (EDOL) as a proxy measure for risk of AOF. This systematic review and meta-analysis sought to determine the prevalence of EDOL and effectiveness of general preventive measures during AF ablation. Methods and results: We searched electronic databases for studies reporting prevalence or prevention of EDOL post-AF ablation...
June 14, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29912206/three-dimensional-organotypic-cultures-of-vestibular-and-auditory-sensory-organs
#9
Ksenia Gnedeva, A J Hudspeth, Neil Segil
The sensory organs of the inner ear are challenging to study in mammals due to their inaccessibility to experimental manipulation and optical observation. Moreover, although existing culture techniques allow biochemical perturbations, these methods do not provide a means to study the effects of mechanical force and tissue stiffness during development of the inner ear sensory organs. Here we describe a method for three-dimensional organotypic culture of the intact murine utricle and cochlea that overcomes these limitations...
June 1, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29912199/a-3-dimensional-3d-printed-template-for-high-throughput-zebrafish-embryo-arraying
#10
Tianyu Yu, Yue Jiang, Sijie Lin
The zebrafish is a globally recognized fresh water organism frequently used in developmental biology, environmental toxicology, and human disease related research fields. Thanks to its unique features, including large fecundity, embryo translucency, rapid and simultaneous development, etc., zebrafish embryos are often used for large scale toxicity assessment of chemicals and drug/compound screening. A typical screening procedure involves adult zebrafish spawning, embryos selection, and arraying the embryos into multi-well plates...
June 1, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29912164/tm-02-quarter-mode-substrate-integrated-waveguide-resonator-for-dual-detection-of-chemicals
#11
Ahmed Salim, Sungjoon Lim
The detection of multiple fluids using a single chip has been attracting attention recently. A TM02 quarter-mode substrate-integrated waveguide resonator designed at 5.81 GHz on RT/duroid 6010LM with a return loss of 13 dB and an unloaded quality factor of Q ≈ 13 generates two distinct strong electric fields that can be manipulated to simultaneously detect two chemicals. Two asymmetric channels engraved in a polydimethylsiloxane sheet are loaded with analyte to produce a unique resonance frequency in each case, regardless of the dielectric constants of the liquids...
June 18, 2018: Sensors
https://www.readbyqxmd.com/read/29912090/rupture-of-the-corpus-cavernosum-in-a-pediatric-patient
#12
Blake C Gruenberg, David Mortel, Amanda Bogie
Pediatric penile pain is an uncommon complaint and is associated with a wide differential diagnosis including infectious, inflammatory, traumatic, and idiopathic conditions. Penile fractures, anatomically known as rupture of the corpus cavernosum, are almost exclusively reported in sexually mature patients and usually involve forceful manipulation during sexual activity. Rupture of the corpus cavernosum is a true urologic emergency. Failure to recognize and treat rupture of the corpus cavernosum has been associated with residual penile angulation, persistent hematoma, abscess, erectile dysfunction, and fibrosis...
June 14, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29911882/meta-lay-theories-of-scientific-potential-drive-underrepresented-students-sense-of-belonging-to-science-technology-engineering-and-mathematics-stem
#13
Aneeta Rattan, Krishna Savani, Meera Komarraju, Megan M Morrison, Carol Boggs, Nalini Ambady
The current research investigates people's perceptions of others' lay theories (or mindsets), an understudied construct that we call meta-lay theories. Six studies examine whether underrepresented students' meta-lay theories influence their sense of belonging to science, technology, engineering, and math (STEM). The studies tested whether underrepresented students who perceive their faculty as believing most students have high scientific aptitude (a universal metatheory) would report a stronger sense of belonging to STEM than those who think their faculty believe that not everyone has high scientific aptitude (a nonuniversal metatheory)...
July 2018: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/29911875/the-relation-between-narcissism-and-laboratory-aggression-is-not-contingent-on-environmental-cues-of-competition
#14
Courtland S Hyatt, Brandon M Weiss, Nathan T Carter, Amos Zeichner, Joshua D Miller
Narcissism has been robustly linked to self-report and lab-based measures of aggression. However, less is known about the role that a competitive context may play in the relations found between narcissism and aggression as measured in behavioral paradigms. In circumstances of competition, narcissistic individuals may be particularly attuned to external indicators of status and use aggression as a way of asserting power and a motivation to "win," rather than to do harm. The goal of the present study was to test the role of competition in understanding the relation between narcissism and related traits (i...
June 18, 2018: Personality Disorders
https://www.readbyqxmd.com/read/29911472/disguise-and-deception-of-action-outcomes-through-sports-garment-design-impair-anticipation-judgments
#15
Nicholas J Smeeton, Matyas Varga, Joe Causer, A Mark Williams
The ability to disguise and deceive action outcomes was examined by manipulating sports garments. In Experiment 1, those with higher and lower skill levels in anticipation predicted the throw direction of an opponent who wore a garment designed to disguise kinetic-chain information. Higher skill anticipators were more adversely affected by the disguise garment than the lower skill anticipators, demonstrating that disguise removed the anticipation advantage. In Experiment 2, using the same occlusion methodology, the effect of deception was examined using 2 garments designed to create visual illusions of motion across the proximal-to-distal sequence of the thrower's action and compared with a white-garment control...
June 17, 2018: Journal of Sport & Exercise Psychology
https://www.readbyqxmd.com/read/29911397/transient-hyperthyroidism-induced-by-thyroid-ultrasound
#16
Rajini K Yatavelli, Steven N Levine
OBJECTIVES: Transient hyperthyroidism has been documented following surgical manipulation or direct trauma to the normal thyroid gland. This has best been studied in patients following parathyroidectomy and also reported following trauma to the neck, strangulation, and vigorous palpation of the thyroid gland. It has not previously been reported following a thyroid ultrasound. METHODS: We report the case of a 58-year-old euthyroid woman with a large nontoxic multinodular goiter who developed transient hyperthyroidism following an ultrasound of the thyroid gland...
June 1, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29911240/controlling-optical-polarization-conversion-with-ge-2-sb-2-te-5-based-phase-change-dielectric-metamaterials
#17
Wei Zhu, Ruisheng Yang, Yuancheng Fan, Quanhong Fu, Hongjing Wu, Peng Zhang, Nian-Hai Shen, Fuli Zhang
Recent progress in the metamaterial-based polarization manipulation of light highlights the promise of novel polarization-dependent optical components and systems. To overcome the limited frequency bandwidth of metamaterials resulting from their resonant nature, it is desirable to incorporate tunability into metamaterial-based polarization manipulations. Here, we propose a dielectric metamaterial for controlling linear polarization conversion using the phase-change characteristic of Ge2Sb2Te5 (GST), whose refractive index changes significantly when transforming from the amorphous phase to the crystalline phase under external stimuli...
June 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29911142/ilizarov-stump-lenthening-can-aggravate-phantom-limb-pain-a-case-report
#18
Konstantin Igorevich Novikov, Koushik Narayan Subramanyam, Sergey V Kolesnikov, Oleg K Chegurov, Elina S Kolesnikova, Abhishek V Mundargi
Ilizarov is an accepted technique for lengthening short amputation stumps to improve prosthetic function and rehabilitation. The relation of stump lengthening and phantom limb pain (PLP) has not been reported in literature. We present here a case report of a transfemoral amputee who had a flare up of PLP following stump lengthening. He responded well to a combination of pharmacological therapy and soft tissue manipulative techniques and desired length was achieved. This report alerts the possibility of aggravation of PLP following stump lengthening and discusses its management...
May 2018: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29911118/evaluation-of-genetic-relationship-between-15-bamboo-species-of-north-east-india-based-on-issr-marker-analysis
#19
Thoungamba Amom, Leimapokpam Tikendra, Hamidur Rahaman, Angamba Potshangbam, Potshangbam Nongdam
The classification of bamboos based on floral morphology and reproductive characters is very hard due to erratic flowering behavior and unusually long reproductive cycle. The application of reliable and effective DNA molecular markers is highly essential to address this problem. In the present investigation, inter-simple sequence repeats (ISSR) markers were employed to study phylogenetic relationship of 15 different bamboos of North-East India. The 10 ISSR primers generated 116 polymorphic loci or scorable bands with average of 11...
March 2018: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/29910734/genes-whose-gain-or-loss-of-function-increases-skeletal-muscle-mass-in-mice-a-systematic-literature-review
#20
Sander A J Verbrugge, Martin Schönfelder, Lore Becker, Fakhreddin Yaghoob Nezhad, Martin Hrabě de Angelis, Henning Wackerhage
Skeletal muscle mass differs greatly in mice and humans and this is partially inherited. To identify muscle hypertrophy candidate genes we conducted a systematic review to identify genes whose experimental loss or gain-of-function results in significant skeletal muscle hypertrophy in mice. We found 47 genes that meet our search criteria and cause muscle hypertrophy after gene manipulation. They are from high to small effect size: Ski, Fst, Acvr2b, Akt1, Mstn, Klf10, Rheb, Igf1, Pappa, Ppard, Ikbkb, Fstl3, Atgr1a, Ucn3, Mcu, Junb, Ncor1, Gprasp1, Grb10, Mmp9, Dgkz, Ppargc1a (specifically the Ppargc1a4 isoform), Smad4, Ltbp4, Bmpr1a, Crtc2, Xiap, Dgat1, Thra, Adrb2, Asb15, Cast, Eif2b5, Bdkrb2, Tpt1, Nr3c1, Nr4a1, Gnas, Pld1, Crym, Camkk1, Yap1, Inhba, Tp53inp2, Inhbb, Nol3, Esr1 ...
2018: Frontiers in Physiology
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