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https://www.readbyqxmd.com/read/29324562/effectiveness-of-interventions-to-prevent-pre-frailty-and-frailty-progression-in-older-adults-a-systematic-review
#1
João Apóstolo, Richard Cooke, Elzbieta Bobrowicz-Campos, Silvina Santana, Maura Marcucci, Antonio Cano, Miriam Vollenbroek-Hutten, Federico Germini, Barbara D'Avanzo, Holly Gwyther, Carol Holland
OBJECTIVE: To summarize the best available evidence regarding the effectiveness of interventions for preventing frailty progression in older adults. INTRODUCTION: Frailty is an age-related state of decreased physiological reserves characterized by an increased risk of poor clinical outcomes. Evidence supporting the malleability of frailty, its prevention and treatment, has been presented. INCLUSION CRITERIA: The review considered studies on older adults aged 65 and over, explicitly identified as pre-frail or frail, who had been undergoing interventions focusing on the prevention of frailty progression...
January 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29295775/-antibiotics-prescription-and-complementary-tests-based-on-frequency-of-use-and-loyalty-in-primary-care
#2
Josep Vicent Balaguer Martínez, Guadalupe Del Castillo Aguas, Ana Gallego Iborra
OBJECTIVE: To assess whether there is a relationship between the prescription of antibiotics and the performance of complementary tests with frequency of use and loyalty in Primary Care. METHODS: Analytical descriptive study performed through a network of Primary Care sentinel paediatricians (PAPenRed). Each paediatrician reviewed the spontaneous visits (in Primary Care and in Emergency Departments) of 15 patients for 12 months, randomly chosen from their quota...
December 30, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29290171/health-care-costs-and-thromboembolic-events-in-hydroxyurea-treated-patients-with-polycythemia-vera
#3
Shreekant V Parasuraman, Nianwen Shi, Dilan C Paranagama, Machaon Bonafede
BACKGROUND: Patients with polycythemia vera (PV) are at increased risk of thromboembolic events (TEs), which are key contributors to reduced overall survival compared with the age- and sex-matched general population. In addition to aspirin and phlebotomy to maintain hematocrit level < 45%, many patients receive cytoreduction with hydroxyurea (HU), which is associated with improved survival and may reduce the risk of cardiovascular events and TEs. However, 1 in 4 patients become resistant to or intolerant of HU...
January 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29287033/impact-of-new-medications-and-4-generic-programs-on-overactive-bladder-treatment-among-older-adults-in-the-united-states-2000-2015
#4
Alan C Kinlaw, Michele Jonsson Funk, Mitchell M Conover, Virginia Pate, Alayne D Markland, Jennifer M Wu
BACKGROUND: Despite several new medications being Food and Drug Administration-approved for overactive bladder (OAB) and new prescription drug payment programs, there are limited population-based data regarding OAB medication use among older adults. OBJECTIVES: To examine: (1) impacts of new medications and $4 generic programs on time trends for OAB-related medication dispensing for older adults in the United States; (2) differences by age and sex; and (3) temporal changes in OAB-related medication payments...
December 28, 2017: Medical Care
https://www.readbyqxmd.com/read/29282333/topiramate-use-early-in-pregnancy-and-the-risk-of-oral-clefts-a-pregnancy-cohort-study
#5
Sonia Hernandez-Diaz, Krista F Huybrechts, Rishi J Desai, Jacqueline M Cohen, Helen Mogun, Page B Pennell, Brian T Bateman, Elisabetta Patorno
OBJECTIVE: To assess the relative risk of oral clefts associated with maternal use of high and low doses of topiramate during the first trimester for epilepsy and nonepilepsy indications. METHODS: This population-based study nested in the US 2000-2010 Medicaid Analytic eXtract included a cohort of 1,360,101 pregnant women with a live-born infant enrolled in Medicaid from 3 months before conception through 1 month after delivery. Oral clefts were defined as the presence of a recorded diagnosis in claims during the first 90 days after birth...
December 27, 2017: Neurology
https://www.readbyqxmd.com/read/29260459/hospital-admissions-due-to-dysglycaemia-and-prescriptions-of-antidiabetic-medications-in-england-and-wales-an-ecological-study
#6
Abdallah Y Naser, Qian Wang, Lisa Y L Wong, Jenni Ilomaki, Simon J Bell, Gang Fang, Ian C K Wong, Li Wei
INTRODUCTION: Hypoglycaemia and hyperglycaemia are common adverse events associated with antidiabetic medications. They are also a common cause of hospital admissions for people with diabetes. The objective of the study was to explore the trends in hospital admissions due to hypoglycaemia and hyperglycaemia and in the prescriptions of antidiabetic medications in England and Wales. METHODS: We conducted an observational study during the period 1999-2016. Hospital admission data for patients from all age groups were extracted from the Hospital Episode Statistics database in England and the Patient Episode Database for Wales...
December 19, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29241093/quantitative-analysis-of-drugs-in-hair-by-uhplc-high-resolution-mass-spectrometry
#7
Robert Kronstrand, Malin Forsman, Markus Roman
Liquid chromatographic methods coupled to high resolution mass spectrometry are increasingly used to identify compounds in various matrices including hair but there are few recommendations regarding the parameters and their criteria to identify a compound. In this study we present a method for the identification and quantification of a range of drugs and discuss the parameters used to identify a compound with high resolution mass spectrometry. Drugs were extracted from hair by incubation in a buffer:solvent mixture at 37°C during 18h...
December 8, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29230712/sensitivity-of-the-medication-possession-ratio-to-modelling-decisions-in-large-claims-databases
#8
Margret V Bjarnadottir, David Czerwinski, Eberechukwu Onukwugha
OBJECTIVES: When preparing administrative medical and pharmacy claims data for analysis, decisions about data clean up and analytical approach need to be made. However, information about the effects of various modelling decisions on adherence measures such as the medication possession ratio (MPR) is limited. We address this gap with this study. METHODS: We utilized cross-sectional administrative claims data for commercially insured members filling at least two prescriptions for drugs within five classes of hypertension medication between 2008 and 2010...
December 11, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29228528/the-dilemma-of-irrational-antibiotic-and-corticosteroid-prescription-in-iran-how-much-it-can-affect-the-medicine-expenditures
#9
Parisa Mehdizadeh, Nooredin Dopeykar, Mohammad Meskarpour-Amiri, Hediyeh Zekri, Mahmoud Salesi
In recent years the high cost of medicines and the lack of it were one of the major problems in developing countries that despite numerous efforts to solve the root causes of this problem, the issue remains, unfortunately. Therefore, this study aimed to assess the impact of antibiotics and corticosteroids prescription on the medicines expenditures. This was descriptive-analytical study that conducted to assess the function of medical expenditures through prescription letters and analysis the factors affecting medicine expenditures...
October 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29210142/internal-validation-of-medicaid-analytic-extract-max-data-capture-for-comprehensive-managed-care-plan-enrollees-from-2007-to-2010
#10
Yan Li, Yanmin Zhu, Chao Chen, Xi Wang, Yoonyoung Choi, Carl Henriksen, Almut G Winterstein
PURPOSE: Because of concerns over incomplete medical encounter capture in Medicaid capitated comprehensive managed care (CMC) plans, researchers have traditionally confined analyses to fee-for-service (FFS) enrollees. We aimed to evaluate the usability of data for CMC enrollees in Medicaid Analytic eXtract (MAX) files for 29 states from 2007 to 2010. METHODS: We applied 7 measures to MAX inpatient, other therapy, and prescription drug files for each state and study year...
December 6, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29200891/conditioning-on-future-exposure-to-define-study-cohorts-can-induce-bias-the-case-of-low-dose-acetylsalicylic-acid-and-risk-of-major-bleeding
#11
Jennifer L Lund, Erzsébet Horváth-Puhó, Szimonetta Komjáthiné Szépligeti, Henrik Toft Sørensen, Lars Pedersen, Vera Ehrenstein, Til Stürmer
Background: A principle of cohort studies is that cohort membership is defined by current rather than future exposure information. Pharmacoepidemiologic studies using existing databases are vulnerable to violation of this principle. We evaluated the impact of using data on future redemption of prescriptions to determine cohort membership, motivated by a published example seeking to emulate a "per-protocol" association between continuous versus never use of low-dose acetylsalicylic acid (ASA) and major bleeding (e...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/29171462/-description-of-postauthorisation-observational-prospective-studies-with-drugs-in-the-valencian-region-between-2010-and-2015-factors-associated-with-their-authorisation
#12
María Antonia Grau Rubio, Fernando Gómez-Pajares, Roberto Izquierdo María, Pedro Zapater Hernández, Sergio Fernández Martínez
OBJECTIVE: Postauthorisation observational studies are crucial source of information on drug effectiveness and safety. The objectives of this work were to describe the characteristics of the postauthorisation observational prospective studies (EPA-SP) for which authorisation was requested in the Valencian region, as well as to explore which factors influenced the aforementioned authorisation. METHODS: We performed a retrospective analytical study comprising all the EPA-SP for which authorisation was requested in the Valencian region between 2010 and 2015...
November 24, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/29158721/knowledge-of-community-pharmacists-about-the-risks-of-medication-use-during-pregnancy-in-central-region-of-saudi-arabia
#13
Ziyad Alrabiah, Mohamed N Al-Arifi, Sultan M Alghadeer, Syed Wajid, Ali AlQahtani, Naif Almotari, AbdAllh AlHwerani, Salmeen D Babelghaith
Background: Community pharmacists (CPs) are the most accessible health care provider to the public, and they have huge duties to improve medication use especially among the pregnant women in their community. The objective of this study was to evaluate knowledge of CPs about the medication safety during pregnancy. Methods: A prospective cross-sectional survey was carried out over practicing community pharmacists in a capital of Saudi Arabia (SA). Pharmacists were asked about the safety of each medicine during pregnancy...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29155848/an-electronic-health-record-based-model-predicts-statin-adherence-ldl-cholesterol-and-cardiovascular-disease-in-the-united-states-military-health-system
#14
Joseph E Lucas, Taylor C Bazemore, Celan Alo, Patrick B Monahan, Deepak Voora
HMG-CoA reductase inhibitors (or "statins") are important and commonly used medications to lower cholesterol and prevent cardiovascular disease. Nearly half of patients stop taking statin medications one year after they are prescribed leading to higher cholesterol, increased cardiovascular risk, and costs due to excess hospitalizations. Identifying which patients are at highest risk for not adhering to long-term statin therapy is an important step towards individualizing interventions to improve adherence. Electronic health records (EHR) are an increasingly common source of data that are challenging to analyze but have potential for generating more accurate predictions of disease risk...
2017: PloS One
https://www.readbyqxmd.com/read/29155174/ethnopharmacology-phytochemistry-and-pharmacology-of-cornus-officinalis-sieb-et-zucc
#15
REVIEW
Jun Huang, Yiwei Zhang, Lin Dong, Qinghan Gao, Lei Yin, Hongfeng Quan, Rong Chen, Xueyan Fu, Dingbo Lin
ETHNOPHARMACOLOGICAL RELEVANCE: Cornus officinalis (Cornaceae), known in Chinese as "Shanzhuyu," is a frequently used traditional Chinese medicine. It tastes sour and is astringent and slightly warm in nature. Its fruits have long been used to treat kidney deficiency, high blood pressure, waist and knee pain, dizziness, tinnitus, impotence, spermatorrhea, menorrhagia, and other diseases in China. The main distribution areas are Shanxi and Gansu. AIM OF THE STUDY: This review focused on the ethnopharmacological uses of the herb...
November 17, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29152542/prescribing-outdoor-physical-activity-to-children-health-care-providers-perspectives
#16
Richard W Christiana, J Joy James, Rebecca A Battista
Little evidence exists on health care provider (HCP) prescriptions for children's outdoor physical activity (PA). Semistructured interviews were conducted with 15 children's HCPs to explore perspectives on outdoor PA prescription programs for children and barriers to implementation. Thematic analytic techniques were used to analyze the data. Most participants reported an awareness of health benefits to children being in the outdoors. Ten themes emerged from the data related to 3 thematic categories: (1) current strategies that HCPs are using to promote PA among children, (2) barriers that HCPs see to prescribing outdoor PA, and (3) potential strategies for promoting outdoor PA among children...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/29149155/lower-cutoffs-for-lc-ms-ms-urine-drug-testing-indicates-better-patient-compliance
#17
Kevin Krock, Amadeo Pesce, Dennis Ritz, Richard Thomas, Agnes Cua, Ryan Rogers, Phil Lipnick, Kristen Kilbourn
BACKGROUND: Urine drug testing is used by health care providers to determine a patient's compliance to their prescribed regimen and to detect non-prescribed medications and illicit drugs. However, the cutoff levels used by clinical labs are often arbitrarily set and may not reflect the urine drug concentrations of compliant patients. OBJECTIVES: Our aim was to test the hypothesis that commonly used cutoffs for many prescribed and illicit drugs were set too high, and methods using these cutoffs may yield a considerable number of false-negative results...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29138943/contaminants-of-emerging-concern-in-surface-waters-in-barbados-west-indies
#18
Quincy A Edwards, Sergei M Kulikov, Leah D Garner-O'Neale, Chris D Metcalfe, Tamanna Sultana
Contaminants of emerging concern (CECs), including pharmaceuticals, artificial sweeteners, steroid hormones, and current-use pesticides have been detected in surface waters around the world, but to date, there have been no reports in the peer-reviewed literature on the levels of these classes of contaminants in freshwater resources in the Caribbean region. In the present study, multi-residue solid phase extraction (SPE) and liquid chromatography with tandem mass spectroscopy (LC-MS/MS) were used to analyze grab samples of surface waters collected from five different watersheds in Barbados, West Indies...
November 14, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29110803/sexual-dysfunction-in-primary-care-an-exploratory-descriptive-analysis-of-medical-record-diagnoses
#19
Katie M Heiden-Rootes, Joanne Salas, Sarah Gebauer, Matthew Witthaus, Jeffrey Scherrer, Kristin McDaniel, Dasha Carver
BACKGROUND: The prevalence of sexual dysfunction (SDx) diagnoses in primary care settings is not well known, which is a concern because of the high prevalence of comorbid chronic health conditions in patients diagnosed with SDx. AIM: To explore the relation of SDx diagnosis, chronic health conditions, and prescription medications commonly associated with SDx for men and women in primary care using medical records diagnoses. METHODS: Exploratory descriptive analyses were used to interpret secondary data from a primary care patient database...
November 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29098768/screening-and-identification-of-potential-hypoglycemic-components-in-zeng-ye-tang-by-high-performance-liquid-chromatography-coupled-with-tandem-quadrupole-time-of-flight-mass-spectrometry
#20
Yu Shan Tian, Zhong Ying Du, Ying Xiao, BoYang Yu, Jin Qi
Zeng Ye Tang, a famous prescription consisting of Xuanshen, Maidong and Shengdi (5:4:4), has been used in China for a long time to treat diabetes caused by excessive heat with yin deficiency. Although many studies have investigated the pharmacological effects of Zeng Ye Tang, the compounds responsible for its hypoglycemic effect have not been identified. In this study, 50 compounds in Zeng Ye Tang were identified by high-performance liquid chromatography coupled with tandem quadrupole time-of-flight mass spectrometry...
November 3, 2017: Journal of Separation Science
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