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https://www.readbyqxmd.com/read/28927550/assessing-dose-variance-from-immobilization-devices-in-vmat-head-and-neck-treatment-planning-a-retrospective-case-study-analysis
#1
Alyssa Olson, Kristine Phillips, Tamara Eng, Nishele Lenards, Ashley Hunzeker, Daniel Lewis, Douglas Baumann
Immobilization devices serve several purposes in radiation oncology including improved positional reproducibility and decreased patient movement. If immobilization device beam attenuation is unaccounted for in the treatment planning process, planning target volume (PTV) coverage can be compromised. A retrospective case study was performed to evaluate beam attenuation from head and neck (HN) immobilization devices in volumetric-modulated arc therapy using the Eclipse treatment planning system and the Anisotropic Analytical Algorithm...
September 15, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28918324/simultaneous-determination-and-pharmacokinetic-study-of-twelve-bioactive-compounds-in-rat-plasma-after-intravenous-administration-of-xuebijing-injection-by-uhplc-q-orbitrap-hrms
#2
Lihua Zuo, Qiuyue Zhong, Zhenhui Wang, Zhi Sun, Lin Zhou, Zhuolun Li, Tanye Xu, Yingying Shi, Jinfa Tang, Shuzhang Du, Xiaojian Zhang
Xuebijing injection (XBJ) is a traditional Chinese herbal prescription widely used in the treatment of sepsis. Extensive studies revealed that the major bioactive constituents of XBJ injection, including phenolic acids, flavonoids, monoterpene glycosides, lactones and organic acids, play an important role in the treatment. In this study, a rapid, sensitive and accurate ultra high performance liquid chromatography - Q Exactive hybrid quadrupole - orbitrap high-resolution accurate mass spectrometry (UHPLC-Q-Orbitrap HRMS) method was developed for simultaneous determination of twelve bioactive compounds in rat plasma after intravenous administration of XBJ injection...
September 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28894587/comparison-of-claims-data-on-hospitalization-rates-and-repeat-procedures-in-patients-receiving-a-bowel-preparation-prior-to-colonoscopy
#3
Lisa E Young, Naomi C Sacks, Philip L Cyr, Abhishek Sharma, David N Dahdal
OBJECTIVES: To evaluate outcomes of colorectal screening using sodium picosulfate and magnesium citrate compared with other prescription bowel-preparation agents. Primary endpoints were rates of procedure-associated hospitalizations, diagnosis at hospitalization, and rates of early repeat screenings. METHODS: This retrospective cohort study identified patients using the Truven Health Analytics MarketScan databases, which contain fully adjudicated, de-identified, medical- and prescription-drug claims, as well as demographic and enrollment information for individuals with commercial, Medicaid, and Medicare supplemental insurance coverage...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28891333/profile-of-medical-care-costs-in-patients-with-amyotrophic-lateral-sclerosis-in-the-medicare-programme-and-under-commercial-insurance
#4
Lisa Meng, Amy Bian, Scott Jordan, Andrew Wolff, Jeremy M Shefner, Jinsy Andrews
OBJECTIVE: To determine amyotrophic lateral sclerosis (ALS)-associated costs incurred by patients covered by Medicare and/or commercial insurance before, during and after diagnosis and provide cost details. METHODS: Costs were calculated from the Medicare Standard Analytical File 5% sample claims data from Parts A and B from 2009, 2010 and 2011 for ALS Medicare patients aged ≥70 years (monthly costs) and ≥65 years (costs associated with disability milestones)...
September 11, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28885946/the-association-between-service-members-participation-in-humanitarian-aid-and-disaster-relief-and-mental-health-symptoms-and-treatments
#5
Yeong Kim, Nilam Patel, Glen Diehl, Patrick Richard
INTRODUCTION: There is a scarcity of research establishing a relationship between mental illness and the U.S. military service members who participate in the field of military humanitarian assistance/disaster relief (HA/DR). One of the few studies in this area showed that participation in military HA/DR was not associated with depressive symptoms, however, the study was limited by sample size. This study examined (1) the relationship between participation in military HA/DR and mental health symptoms and military stress and (2) the relationship between HA/DR and mental health treatment and therapy...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28869577/forsythiae-fructus-a-review-on-its-phytochemistry-quality-control-pharmacology-and-pharmacokinetics
#6
REVIEW
Zhanglu Dong, Xianyuan Lu, Xueli Tong, Yaqian Dong, Lan Tang, Menghua Liu
Forsythiae Fructus, as a traditional Chinese medicine, has been widely used both as a single herb and in compound prescriptions in Asia, mainly due to its heat-clearing and detoxifying effects. Modern pharmacology has proved Forsythiae Fructus possesses various therapeutic effects, both in vitro and in vivo, such as anti-inflammatory, antibacterial and antiviral activities. Up to now, three hundred and twenty-one compounds have been identified and sensitive analytical methods have been established for its quality control...
September 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28862306/novel-hplc-uv-method-for-simultaneous-determination-of-fat-soluble-vitamins-and-coenzyme-q10-in-medicines-and-supplements
#7
Žane Temova-Rakuša, Eva Srečnik, Robert Roškar
A precise, accurate and rapid HPLC-UV method for simultaneous determination of fat-soluble vitamins (vitamin D3, E-acetate, K1, β-carotene, A-palmitate) and coenzyme Q10 was developed and validated according to ICH guidelines. Optimal chromatographic separation of the analytes in minimal analysis time (8 min) was achieved on a Luna C18 150 × 4.6 mm column using a mixture of acetonitrile, tetrahydrofuran and water (50:45:5, v/v/v). The described reversed phase HPLC method is the first published for quantification of these five fat-soluble vitamins and coenzyme Q10 within a single chromatographic run...
September 2017: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/28826908/-comparison-of-predictive-models-for-the-selection-of-high-complexity-patients
#8
Marcos Estupiñán-Ramírez, Rita Tristancho-Ajamil, María Consuelo Company-Sancho, Hilda Sánchez-Janáriz
OBJECTIVE: To compare the concordance of complexity weights between Clinical Risk Groups (CRG) and Adjusted Morbidity Groups (AMG). To determine which one is the best predictor of patient admission. To optimise the method used to select the 0.5% of patients of higher complexity that will be included in an intervention protocol. METHOD: Cross-sectional analytical study in 18 Canary Island health areas, 385,049 citizens were enrolled, using sociodemographic variables from health cards; diagnoses and use of healthcare resources obtained from primary health care electronic records (PCHR) and the basic minimum set of hospital data; the functional status recorded in the PCHR, and the drugs prescribed through the electronic prescription system...
August 18, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28802217/comparatively-evaluating-the-pharmacokinetic-of-fifteen-constituents-in-normal-and-blood-deficiency-rats-after-oral-administration-of-xin-sheng-hua-granule-by-uplc-ms-ms
#9
Han-Qing Pang, Yu-Ping Tang, Yu-Jie Cao, Ya-Jie Tan, Yi Jin, Xu-Qin Shi, Sheng-Liang Huang, Da-Zheng Sun, Jin Sun, Zhi-Shu Tang, Jin-Ao Duan
Xin-Sheng-Hua Granule (XSHG), a famous traditional Chinese medicine prescription, are clinically applied for the treatment of postpartum disease through nourishing blood and promoting blood circulation. In this investigation, a multi-constituents (trigonelline, stachydrine hydrochloride, hydroxysafflor yellow A, chlorogenic acid, amygdalin, leonurine, liquiritin, ferulic acid, senkyunolide I, senkyunolide H, glycyrrhizic acid, senkyunolide A, ligustilide, butylidenephthalide and glycyrrhetinic acid) pharmacokinetic study of XSHG was conducted for the first time...
September 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28797023/assessing-antiretroviral-use-during-gaps-in-hiv-primary-care-using-multisite-medicaid-claims-and-clinical-data
#10
Anne K Monroe, John A Fleishman, Cindy C Voss, Jeanne C Keruly, Ank E Nijhawan, Allison L Agwu, Judith A Aberg, Richard M Rutstein, Richard D Moore, Kelly A Gebo
BACKGROUND: Some individuals who appear poorly retained by clinic visit-based retention measures are using antiretroviral therapy (ART) and maintaining viral suppression. We examined whether individuals with a gap in HIV primary care (≥180 days between HIV outpatient clinic visits) obtained ART during that gap after 180 days. SETTING: HIV Research Network data from 5 sites and Medicaid Analytic Extract eligibility and pharmacy data were combined. METHODS: Factors associated with having both an HIV primary care gap and a new (ie, nonrefill) ART prescription during a gap were evaluated with multinomial logistic regression...
September 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28768628/risk-of-neonatal-drug-withdrawal-after-intrauterine-co-exposure-to-opioids-and-psychotropic-medications-cohort-study
#11
Krista F Huybrechts, Brian T Bateman, Rishi J Desai, Sonia Hernandez-Diaz, Kathryn Rough, Helen Mogun, Leslie S Kerzner, Jonathan M Davis, Megan Stover, Devan Bartels, Jennifer Cottral, Elisabetta Patorno
Objectives To assess the impact of in utero co-exposure to psychotropic medications and opioids on the incidence and severity of neonatal drug withdrawal.Design Observational cohort study.Setting Nationwide sample of pregnancies in publicly insured women in the US, nested in the Medicaid Analytic eXtract (2000-10).Participants 201 275 pregnant women with public insurance who were exposed to opioids around the time of delivery and their liveborn infants.Interventions In utero exposure to psychotropic medications, in particular antidepressants, atypical antipsychotics, benzodiazepines, gabapentin, and non-benzodiazepine hypnotics (Z drugs), with prescriptions filled within the same time window as prescriptions for opioids...
August 2, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28758363/validation-of-an-lc-ms-ms-method-for-analysis-of-anti-diabetic-drugs-in-botanical-dietary-supplements-labeled-for-blood-sugar-management
#12
Jun Ma, Rahul S Pawar, Erich Grundel
We developed and validated a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to detect and quantitate 14 anti-diabetic, 2 anti-obesity, and 3 cholesterol-lowering drugs in botanical dietary supplements marketed for blood sugar management. Many botanical dietary supplements which carry label statements related to blood sugar management are available over the Internet. Potential adulteration of such dietary supplements with anti-diabetic and other prescription drugs, some of which have been removed from the market due to adverse events, is of concern...
July 31, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28755504/multi-components-determination-of-traditional-chinese-medicine-preparation-yin-zhi-huang-injection-by-lc-ms-ms-for-screening-of-its-potential-bioactive-candidates-using-heparg-cells
#13
Zhi Rao, Fan Zhang, Xiao-Yi Zhang, Guo-Qiang Zhang, Yan-Rong Ma, Yan Zhou, Hong-Yan Qin, Xin-An Wu, Yu-Hui Wei
Yin-zhi-huang (YZH) injection is an injectable multi-herbal prescription derived from the ancient Chinese medicine formula of Yin-chen-hao-tang, which is widely used in the clinic for the treatment of jaundice and chronic liver diseases. To date, the systematic study of the components in this multi-herbal prescription is still challenged by desirable analytical methods, by which a big array of components could be simultaneously detected at low concentrations. Herein, a new liquid chromatography- tandem mass spectrometry (LC-MS/MS) method by using dynamic multiple reaction monitoring (DMRM) mode was developed to determine multiple peaks in traditional Chinese medicine (TCM) preparation YZH injection...
July 29, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28755103/the-effect-of-weekly-set-volume-on-strength-gain-a-meta-analysis
#14
REVIEW
Grant W Ralston, Lon Kilgore, Frank B Wyatt, Julien S Baker
BACKGROUND: Strength training set organisation and its relationship to the development of muscular strength have yet to be clearly defined. Current meta-analytical research suggests that different population groups have distinctive muscular adaptations, primarily due to the prescription of the strength training set dose. OBJECTIVES: We conducted a meta-analysis with restrictive inclusion criteria and examined the potential effects of low (LWS), medium (MWS) or high weekly set (HWS) strength training on muscular strength per exercise...
July 28, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28744886/development-and-validation-of-an-lc-ms-ms-method-for-the-simultaneous-quantification-of-seven-constituents-in-rat-plasma-and-application-in-a-pharmacokinetic-study-of-the-zaoren-anshen-prescription
#15
Ajing Zhao, Li Zhang, Rong Li, Jiao Shang, Huihui Yi, Yuan Wang, Dian Zhang, Shixiang Wang, Minfeng Fang
A sensitive, specific and accurate liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous determination of seven constituents of the Zaoren Anshen prescription (ZAP) in rat plasma after oral administration of the ZAP: spinosin, salvianic acid A, 6"'-feruloylspinosin, protocatechualdehyde, salvianolic acid B, schisandrin and deoxyschisandrin. The plasma samples and the internal standard (IS) sulfamethoxazole were extracted using acetonitrile. Chromatographic separation was performed with an Agilent HC-C18 column using a gradient elution profile and a mobile phase consisting of 0...
July 26, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28741327/-prescription-pattern-in-the-management-of-type-i-open-forearm-fractures-in-pediatric-patients
#16
J A López-Tello, B J Torres-Fernández, N G Escalona-Reynoso
BACKGROUND: Pediatric open fractures account for more tan 10% of hospital admissions in a Pediatric Trauma Clinical Department. It is important to identify the predominant surgical management prescription pattern in pediatric patients presenting with Type I open forearm fractures at a referral center in an emerging economy. MATERIAL AND METHODS: Observational, cross-sectional, analytical, secondary-source (logs) sampling study of consecutive cases. The cases included subjects under 17 years of age presenting with Type I open forearm fractures at a Pediatric Trauma Clinical Department from January 1st, 2009 to December 31st, 2013...
January 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28711478/dosimetric-comparison-of-peripheral-nsclc-sbrt-using-acuros-xb-and-aaa-calculation-algorithms
#17
Chloe C H Ong, Khong Wei Ang, Roger C X Soh, Kah Ming Tin, Jerome H H Yap, James C L Lee, Christopher M Bragg
There is a concern for dose calculation in highly heterogenous environments such as the thorax region. This study compares the quality of treatment plans of peripheral non-small cell lung cancer (NSCLC) stereotactic body radiation therapy (SBRT) using 2 calculation algorithms, namely, Eclipse Anisotropic Analytical Algorithm (AAA) and Acuros External Beam (AXB), for 3-dimensional conformal radiation therapy (3DCRT) and volumetric-modulated arc therapy (VMAT). Four-dimensional computed tomography (4DCT) data from 20 anonymized patients were studied using Varian Eclipse planning system, AXB, and AAA version 10...
July 12, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28709229/phenomenology-of-stochastic-exponential-growth
#18
Dan Pirjol, Farshid Jafarpour, Srividya Iyer-Biswas
Stochastic exponential growth is observed in a variety of contexts, including molecular autocatalysis, nuclear fission, population growth, inflation of the universe, viral social media posts, and financial markets. Yet literature on modeling the phenomenology of these stochastic dynamics has predominantly focused on one model, geometric Brownian motion (GBM), which can be described as the solution of a Langevin equation with linear drift and linear multiplicative noise. Using recent experimental results on stochastic exponential growth of individual bacterial cell sizes, we motivate the need for a more general class of phenomenological models of stochastic exponential growth, which are consistent with the observation that the mean-rescaled distributions are approximately stationary at long times...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28705340/-factors-of-compliance-with-the-wearing-of-elastic-compression-stockings-in-a-sub-saharan-population
#19
E Soya, J J N'djessan, J Koffi, E Monney, E Tano, C Konin
INTRODUCTION: Elastic venous compression is the basic treatment of chronic venous insufficiency (CVI) and deep vein thrombosis (DVT). Very little data exist in sub-Saharan Africa concerning the wearing of compression stockings. AIM: To determine the factors of compliance with wearing elastic compression stockings. MATERIALS AND METHODS: This retrospective cross-sectional descriptive and analytical study involved 200 consecutive patients (93 cases of DVT, 94 cases of CVI, 13 cases of DVT and CVI)...
July 2017: J Med Vasc
https://www.readbyqxmd.com/read/28686397/-preanalytical-step-in-bacteriology-a-practical-overview-for-family-physicians
#20
Myriam M Eyer, Sara Droz
Physicians play a key role in the accuracy of bacteriological results by appropriate prescription and the quality of sample collection, preservation and transport. Samples for diagnostic purposes are of use if analysis results have an impact on the therapeutic approach. They have minimal risk of contamination, are usually obtained invasively, and may be targeted to detection of specific bacteria. Physicians should refer to the laboratory technical manual to provide proper sample quality. Furthermore, they have to provide clinical and administrative information to the microbiologist, because the laboratory analytical process depends on these...
October 12, 2016: Revue Médicale Suisse
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