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https://www.readbyqxmd.com/read/27929515/an-innovative-method-to-acquire-the-location-of-point-a-for-cervical-cancer-treatment-by-hdr-brachytherapy
#1
Liyun Chang, Sheng-Yow Ho, Shyh-An Yeh, Tsair-Fwu Lee, Pang-Yu Chen
Brachytherapy of local cervical cancer is generally accomplished through film-based treatment planning with the prescription directed to point A, which is invisible on images and is located at a high-dose gradient area. Through a standard reconstruction method by digitizing film points, the location error for point A would be 3mm with a condition of 30° curvature tandem, which is 10° away from the gantry rotation axis of a simulator, and has an 8.7 cm interval between the flange and the isocenter. To reduce the location error of the reconstructed point A, this paper proposes a method and demonstrates its accuracy...
November 8, 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27906782/predicting-heart-dose-in-breast-cancer-patients-who-received-3d-conformal-radiation-therapy
#2
Daniel Wollschläger, Heiko Karle, Marcus Stockinger, Detlef Bartkowiak, Sandra Bührdel, Hiltrud Merzenich, Thomas Wiegel, Heinz Schmidberger, Maria Blettner
Cardiac late effects are a major health concern for long-term survivors after radiotherapy for breast cancer. Large cohort studies to better understand the exact dose-response relationship require individual estimates of radiation dose to the heart. To predict individual cardiac dose from information that is typically available for all members of a retrospective epidemiological cohort study, 774 female breast cancer patients treated with megavoltage tangential field radiotherapy in 1998-2008 were examined. All dose distributions were calculated using Eclipse with the anisotropic analytical algorithm (AAA) for photon fields and the electron Monte Carlo algorithm for electron boost fields...
January 2017: Health Physics
https://www.readbyqxmd.com/read/27901359/buprenorphine-transdermal-system-utilization
#3
Laura Wallace, Aditi Kadakia
OBJECTIVES: To evaluate utilization patterns in patients initiating buprenorphine transdermal system (BTDS), CIII, and estimate the proportion decreasing their total opioid dose over time. METHODS: This retrospective cohort study used data from the Truven Health Analytics MarketScan® Commercial Claims and Encounters Database from January 1, 2011 through December 31, 2015. Eligible individuals were adults aged 18-64 years newly dispensed BTDS (index prescription) who had at least six months of insurance coverage prior to (baseline period) and following (study period) the index prescription...
November 30, 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27886469/quantum-simulation-of-the-factorization-problem
#4
Jose Luis Rosales, Vicente Martin
Feynman's prescription for a quantum simulator was to find a Hamitonian for a system that could serve as a computer. The Pólya-Hilbert conjecture proposed the demonstration of Riemann's hypothesis through the spectral decomposition of Hermitian operators. Here we study the problem of decomposing a number into its prime factors, N=xy, using such a simulator. First, we derive the Hamiltonian of the physical system that simulates a new arithmetic function formulated for the factorization problem that represents the energy of the computer...
November 11, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27875247/comorbidity-prevalence-healthcare-utilization-and-expenditures-of-medicaid-enrolled-adults-with-autism-spectrum-disorders
#5
Rini Vohra, Suresh Madhavan, Usha Sambamoorthi
A retrospective data analysis using 2000-2008 three state Medicaid Analytic eXtract was conducted to examine the prevalence and association of comorbidities (psychiatric and non-psychiatric) with healthcare utilization and expenditures of fee-for-service enrolled adults (22-64 years) with and without autism spectrum disorders (International Classification of Diseases, Ninth Revision-clinical modification code: 299.xx). Autism spectrum disorder cases were 1:3 matched to no autism spectrum disorder controls by age, gender, and race using propensity scores...
October 20, 2016: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/27873285/prescription-drug-use-and-polypharmacy-among-medicaid-enrolled-adults-with-autism-a-retrospective-cross-sectional-analysis
#6
Rini Vohra, Suresh Madhavan, Usha Sambamoorthi, Claire StPeter, Susannah Poe, Nilanjana Dwibedi, Mayank Ajmera
BACKGROUND: A lack of gold standard treatment for autism spectrum disorders (ASD), no clear ASD management guidelines, and lack of evidence-based pharmacological interventions other than aripiprazole and risperidone elevate the risk of off-label prescribing and adverse effects among individuals with ASD, more so among adults. OBJECTIVE: The aim of this study was to identify and compare the types of prescription drug use, rates of polypharmacy, and characteristics associated with polypharmacy among adults with and without ASD in a retrospective cross-sectional analysis of a three-state Medicaid Analytic eXtract database (2000-2008)...
December 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27863921/unhealthy-weight-management-practices-and-non-medical-use-of-prescription-drugs
#7
Heather B Clayton, Zewditu Demissie, Richard Lowry, Elizabeth A Lundeen, Andrea J Sharma, Michele K Bohm
INTRODUCTION: Non-medical use of prescription drugs (NMUPD) has reached epidemic proportions in the U.S. With approximately one in five high school students engaging in NMUPD, it is important to understand behavioral correlates. METHODS: Data were combined from the 2011 and 2013 cycles of the Youth Risk Behavior Survey, a nationally representative, cross-sectional survey. After restricting the analytic sample to students who reported a weight loss goal of either staying the same weight or losing weight, logistic regression models were used to estimate adjusted prevalence ratios and 95% CIs for associations between unhealthy weight management practices (UWMPs) and lifetime NMUPD...
October 31, 2016: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27857770/assessment-of-dimensional-accuracy-of-preadjusted-metal-injection-molding-orthodontic-brackets
#8
Shiva Alavi, Farnaz Tajmirriahi
BACKGROUND: the aim of this study is to evaluate the dimensional accuracy of McLaughlin, Bennett, and Trevisi (MBT) brackets manufactured by two different companies (American Orthodontics and Ortho Organizers) and determine variations in incorporation of values in relation to tip and torque in these products. MATERIALS AND METHODS: In the present analytical/descriptive study, 64 maxillary right central brackets manufactured by two companies (American Orthodontics and Ortho Organizers) were selected randomly and evaluated for the accuracy of the values in relation to torque and angulation presented by the manufacturers...
September 2016: Dental Research Journal
https://www.readbyqxmd.com/read/27833667/connection-between-depression-and-inability-to-fill-prescriptions-in-rural-fqhc-patients-with-chronic-disease
#9
K Bryant Smalley, Jacob C Warren, K Nikki Barefoot
The purpose of this paper was to (1) examine the rates of elevated depression symptoms among a sample of rural Federally Qualified Health Center (FQHC) patients with chronic disease and (2) determine if an inability to afford general prescription medications within the past 12 months is a significant predictor of depression symptoms among these patients. These data came from Project EDUCATE, an ongoing five-year study designed to be a large-scale, multifocal examination of the needs and experiences of rural FQHC patients with hypertension and/or diabetes...
April 2016: Rural Mental Health
https://www.readbyqxmd.com/read/27828580/an-evaluation-of-elderly-people-s-understanding-of-pharmacotherapy-among-those-treated-in-the-primary-healthcare-system-in-belo-horizonte-brazil
#10
Isabela Vaz Leite Pinto, Adriano Max Moreira Reis, Celline Cardoso Almeida-Brasil, Micheline Rosa da Silveira, Marina Guimarães Lima, Maria das Graças Braga Ceccato
There are a greater number of elderly people with diseases which has led to a greater use in medication and complexity in pharmacotherapy. The aim of this study was to understand the level of understanding on pharmacotherapy amongst the elderly and associated factors. An analytical transversal study was carried out in the Primary Health Care Units. Sociodemographic, clinical, and functional characteristics relative to the use of medication were explored. The level of understanding was obtained after a concordance analysis had been done based on the responses from the interviewees and the information on the medical prescriptions such as: name of medication, dosage, frequency, indication, precautions and side effects...
November 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27805766/determination-of-dasatinib-in-the-tablet-dosage-form-by-ultra-high-performance-liquid-chromatography-capillary-zone-electrophoresis-and-sequential-injection-analysis
#11
Aroa Garcia Gonzalez, Lukáš Taraba, Jakub Hraníček, Petr Kozlík, Pavel Coufal
Dasatinib is a novel oral prescription drug proposed for treating adult patients with chronic myeloid leukemia. Three analytical methods, namely ultra high performance liquid chromatography, capillary zone electrophoresis, and sequential injection analysis, were developed, validated and compared for determination of the drug in the tablet dosage form. The total analysis time of optimized ultra high performance liquid chromatography and capillary zone electrophoresis methods was 2.0 and 2.2 min, respectively...
November 2, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27798073/drugged-drivers-blood-concentrations-in-england-and-wales-prior-to-the-introduction-of-per-se-limits
#12
Brian Rooney, Goncalo Jorge Gouveia, Neville Isles, Lynda Lawrence, Tara Brodie, Zorana Grahovac, Mark Chamberlain, Gavin Trotter
This report details the blood concentration of drugs found in motorists suspected of driving under the influence of drugs from 2010 to 2012 in England and Wales. This study was carried out as new legislation has come into place, setting fixed blood concentration limits for drugs in motorists. These include a cannabis (Δ9-THC) blood concentration of 2 µg/L, amphetamine 250 µg/L, benzoylecgonine (BZE) 50 µg/L, cocaine 10 µg/L, 6-monoacetylmorphine 5 µg/L, morphine 80 µg/L, diazepam 550 µg/L and methadone 500 µg/L...
October 26, 2016: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/27789258/national-trends-in-direct-healthcare-expenditures-among-us-adults-with-migraine-2004-2013
#13
Amit D Raval, Anal Shah
: Migraine is a common neurological disorder with significant economic burden in the United States. However, changes in the economic burden of migraine in the past decade have not been examined given therapeutic advances at the national level. Therefore, we estimated cross-sectional trends in the incremental total and types of direct healthcare expenditures among individuals with migraine using a nationally representative data, the Medical Expenditures Panel Survey. The analytic sample comprised of a weighted population of 228,010,000 adults aged 18 years and older from 2004 to 2013...
October 24, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27789043/comparison-of-adherence-to-rivaroxaban-versus-apixaban-among-patients-with-atrial-fibrillation
#14
Colleen A McHorney, Eric D Peterson, François Laliberté, Guillaume Germain, Winnie W Nelson, Concetta Crivera, Jeffrey Schein, Patrick Lefebvre
PURPOSE: Non-vitamin K antagonist oral anticoagulant medications are increasingly used for stroke prophylaxis in patients with nonvalvular atrial fibrillation (NVAF). This study aimed to compare adherence with rivaroxaban and apixaban among patients with NVAF in routine clinical practice. METHODS: Using pharmacy and medical claims from Truven Health Analytics MarketScan databases, we identified NVAF patients aged ≥18 years treated with rivaroxaban or apixaban...
October 24, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27771203/-molecular-diagnosis-of-human-papillomaviruses-hpv-what-test-s-in-clinical-practice
#15
D Guenat, D Riethmuller, R Ramanah, A Morel, F Aubin, C Mougin, J-L Prétet
Prescription of an HPV test in practice will enable the clinician to optimize the monitoring and the management of patients, especially in the context of cervical cancer screening. Numerous HPV tests are available that present different analytical and clinical sensitivity and specificity. International recommendations on clinical performance of HPV tests used for cervical cancer screening have been published by a group of experts, and tests that meet these performance criteria should be used. Apart from the HPV detection kit, the whole circuit from sampling to report of the results must be considered...
October 19, 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/27753560/association-of-hospitalization-with-first-line-antidepressant-polypharmacy-among-veterans-of-iraq-and-afghanistan-with-post-traumatic-stress-disorder-examining-the-influence-of-methodological-approaches
#16
Eileen M Stock, Laurel A Copeland, Jack Y Tsan, John E Zeber, Michael A Veronin, Alexander W Thompson
OBJECTIVE: To compare the influence of various statistical analysis approaches while assessing the marginal effect of polypharmacy (prescription of multiple psychotropics including a first-line antidepressant) on all-cause hospital admission among veterans diagnosed with post-traumatic stress disorder. METHODS: Data were obtained on 398 Iraq/Afghanistan veterans being followed in a southwestern U.S. health care system from October 2005 through September 2009, diagnosed with post-traumatic stress disorder and receiving first-line antidepressants (serotonin selective or serotonin norepinephrine reuptake inhibitors)...
October 2016: Military Medicine
https://www.readbyqxmd.com/read/27748946/data-analytics-for-continuous-renal-replacement-therapy-historical-limitations-and-recent-technology-advances
#17
William R Clark, Francesco Garzotto, Mauro Neri, Anna Lorenzin, Marta Zaccaria, Claudio Ronco
PURPOSE: Dialysis is a highly quantitative therapy involving large volumes of both clinical and technical data. While automated data collection has been implemented for chronic dialysis, this has not been done for acute kidney injury patients treated with continuous renal replacement therapy (CRRT). METHODS: After a brief review of the fundamental aspects of electronic medical records (EMRs), a new tool designed to provide clinicians with individualized CRRT treatment data is analyzed, with emphasis on its quality assurance capabilities...
October 10, 2016: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/27711930/morbidity-and-mortality-following-relocation-of-highly-dependent-long-term-care-residents-a-retrospective-analytical-study
#18
Sarah Mello, Kieran A O'Connor
In recent years, 1,200 long-term care facility (LTCF) beds have been closed in Ireland, resulting in residents being transferred between facilities. The current study examined morbidity and mortality in residents relocated between LTCFs. The outcomes were studied for residents who transferred between LTCFs compared to residents who did not move (i.e., controls). A retrospective analysis was performed recording demographic data and markers of function and frailty. As a measure of morbidity, new antidepressant medication prescriptions and antibiotic drug use were examined...
October 5, 2016: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/27697727/development-and-application-of-a-multi-component-lc-ms-ms-method-for-determination-of-designer-benzodiazepines-in-urine
#19
Madeleine Pettersson Bergstrand, Anders Helander, Olof Beck
New psychoactive substances (NPS) have become an increasing drug problem in the past decade. For detection of NPS, new analytical methods have to be developed, and the methods also have to be updated regularly. This study aimed at developing a multi-component LC-MS/MS method for detection and quantification of 11 NPS of the benzodiazepine sub-class ("designer benzodiazepines") in urine specimens. The method involves dilution of urine with internal standard and hydrolysis of any glucuronide conjugated forms...
November 1, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27694349/using-mobile-technology-to-optimize-disease-surveillance-and-healthcare-delivery-at-mass-gatherings-a-case-study-from-india-s-kumbh-mela
#20
Dhruv S Kazi, P Gregg Greenough, Rishi Madhok, Aaron Heerboth, Ahmed Shaikh, Jennifer Leaning, Satchit Balsari
BACKGROUND: Planning for mass gatherings often includes temporary healthcare systems to address the needs of attendees. However, paper-based record keeping has traditionally precluded the timely application of collected clinical data for epidemic surveillance or optimization of healthcare delivery. We evaluated the feasibility of harnessing ubiquitous mobile technologies for conducting disease surveillance and monitoring resource utilization at the Allahabad Kumbh Mela in India, a 55-day festival attended by over 70 million people...
September 21, 2016: Journal of Public Health
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