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https://www.readbyqxmd.com/read/28088740/associations-between-adverse-childhood-experiences-student-teacher-relationships-and-non-medical-use-of-prescription-medications-among-adolescents
#1
Myriam Forster, Amy L Gower, Iris W Borowsky, Barbara J McMorris
OBJECTIVE: Few studies have investigated associations between adverse childhood experiences (ACE) and nonmedical use of prescription medication (NMUPM) in population-based samples of adolescents, and even fewer have examined whether promotive factors might buffer these effects. The present study assesses the direct effects of ACE and positive student-teacher relationships on NUMPD and whether positive student-teacher relationships moderate this association. DESIGN: Data were from the 2013 Minnesota Student Survey (MSS), an in-school survey administered every three years to students throughout Minnesota...
January 6, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28087312/immunisation-choice-of-host-adjuvants-and-boosting-schedules-with-emphasis-on-polyclonal-antibody-production
#2
REVIEW
Philippe Delahaut
Polyclonal antibodies are frequently used as immunodiagnostic tools in fundamental research. They are also used for routine diagnostic purposes in human and veterinary medicine and for quality control procedures in the food-processing industry. The antibody is a major component of the detection system. It binds with the molecule to be identified. This conjugate is subsequently revealed by means of binding the antibody with a radio-isotope, a fluorescent substance, an enzyme inducing a color change, or a biosensor based analytical system...
January 10, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28081042/detection-of-hydrocodone-and-morphine-as-metabolites-in-oral-fluid-by-lc-ms-ms-in-patients-prescribed-codeine
#3
Robert E West, Maria G Guevara, Charles Mikel, Ruben Gamez
A retrospective analysis of oral fluid drug testing results using LC-MS/MS was performed to determine the prevalence rates in oral fluid for codeine (COD) and 3 COD metabolites-morphine (MOR), norhydrocodone (NHC), and hydrocodone (HCOD). Oral fluid samples were collected using Quantisal oral fluid collection device (Immunalysis Inc.) and submitted to Millennium Health, LLC for the routine drug analysis by LC-MS/MS. Consistent with previously published literature, COD was the primary analyte detected in oral fluid after the use of COD...
February 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28068462/extent-time-course-and-moderators-of-antipsychotic-treatment-in-youth-with-mood-disorders-results-of-a-meta-analysis-and-meta-regression-analyses
#4
Chiara Cervesi, Su Young Park, Britta Galling, Silvia Molteni, Gabriele Masi, Tobias Gerhard, Mark Olfson, Christoph U Correll
OBJECTIVE: To meta-analytically examine the trends and correlates of antipsychotic use in youth with mood disorders. METHODS: Systematic literature search without language restriction in PubMed/MEDLINE/PsycINFO from database inception through March 2015 using the following search terms: (antipsychotic* OR neuroleptic* OR "dopamine blocker*" OR antidopaminergic) AND (child* OR adolescen* OR pediatric OR youth) AND (prescription* OR prescrib* OR use OR utilization OR database OR pharmacoepidemiolog* OR frequency OR rate OR rates)...
January 3, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28048413/su-f-t-609-impact-of-dosimetric-variation-for-prescription-dose-using-analytical-anisotropic-algorithm-aaa-in-lung-sbrt
#5
D Kawai, R Takahashi, T Kamima, H Baba, T Yamamoto, Y Kubo, S Ishibashi, Y Higuchi, K Tani, H Tachibana
PURPOSE: Actual irradiated prescription dose to patients cannot be verified. Thus, independent dose verification and second treatment planning system are used as the secondary check. AAA dose calculation engine has contributed to lung SBRT. We conducted a multi-institutional study to assess variation of prescription dose for lung SBRT when using AAA in reference to using Acuros XB and Clarkson algorithm. METHODS: Six institutes in Japan participated in this study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047901/we-ab-207b-06-dose-and-biological-uncertainties-in-sarcoma
#6
M Marteinsdottir, J Schuemann, H Paganetti
PURPOSE: To understand the clinical impact of key uncertainties in proton therapy potentially affecting the analysis of clinical trials, namely the assumption of using a constant relative biological effectiveness (RBE) of 1.1 compared to variable RBE for proton therapy and the use of analytical dose calculation (ADC) methods. METHODS: Proton dose distributions were compared for analytical and Monte Carlo (TOPAS) dose calculations. In addition, differences between using a constant RBE of 1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047688/su-f-t-622-comparative-analysis-of-pencil-beam-and-anisotropic-analytical-algorithm-aaa-for-stereotactic-body-radiation-therapy-sbrt-of-thoracic-spine
#7
R Badkul, W Nicolai, D Pokhrel, T Ramanjappa, H Jiang, F Wang, C Lominskac
PURPOSE: To compare the impact of Pencil Beam(PB) and Anisotropic Analytic Algorithm(AAA) dose calculation algorithms on OARs and planning target volume (PTV) in thoracic spine stereotactic body radiation therapy (SBRT). METHODS: Ten Spine SBRT patients were planned on Brainlab iPlan system using hybrid plan consisting of 1-2 non-coplanar conformal-dynamic arcs and few IMRT beams treated on NovalisTx with 6MV photon. Dose prescription varied from 20Gy to 30Gy in 5 fractions depending on the situation of the patient...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047446/su-f-t-132-variable-rbe-models-predict-possible-underestimation-of-vaginal-dose-for-anal-cancer-patients-treated-using-single-field-proton-treatments
#8
A McNamara, T Underwood, J Wo, H Paganetti
PURPOSE: Anal cancer patients treated using a posterior proton beam may be at risk of vaginal wall injury due to the increased linear energy transfer (LET) and relative biological effectiveness (RBE) at the beam distal edge. We investigate the vaginal dose received. METHODS: Five patients treated for anal cancer with proton pencil beam scanning were considered, all treated to a prescription dose of 54 Gy(RBE) over 28-30 fractions. Dose and LET distributions were calculated using the Monte Carlo simulation toolkit TOPAS...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047361/su-f-t-157-physics-considerations-regarding-dosimetric-accuracy-of-analytical-dose-calculations-for-small-field-proton-therapy-a-monte-carlo-study
#9
C Geng, J Daartz, K Cheung, M Bussiere, H Shih, H Paganetti, J Schuemann
PURPOSE: To evaluate the accuracy of dose calculations by analytical dose calculation methods (ADC) for small field proton therapy in a gantry based passive scattering facility. METHODS: 50 patients with intra-cranial disease were evaluated in the study. Treatment plans followed standard prescription and optimization procedures of proton stereotactic radiosurgery. Dose distributions calculated with the Monte Carlo (MC) toolkit TOPAS were used to represent delivered treatments...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046240/we-h-brc-05-catastrophic-error-metrics-for-radiation-therapy
#10
S Murphy, J Molloy
PURPOSE: Intuitive evaluation of complex radiotherapy treatments is impractical, while data transfer anomalies create the potential for catastrophic treatment delivery errors. Contrary to prevailing wisdom, logical scrutiny can be applied to patient-specific machine settings. Such tests can be automated, applied at the point of treatment delivery and can be dissociated from prior states of the treatment plan, potentially revealing errors introduced early in the process. METHODS: Analytical metrics were formulated for conventional and intensity modulated RT (IMRT) treatments...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28033584/identification-bioactivity-evaluation-and-pharmacokinetics-of-multiple-components-in-rat-serum-after-oral-administration-of-xian-ling-gu-bao-capsule-by-ultra-performance-liquid-chromatography-coupled-with-quadrupole-time-of-flight-tandem-mass-spectrometry
#11
Zhi-Hong Yao, Zi-Fei Qin, Liang-Liang He, Xin-Luan Wang, Yi Dai, Ling Qin, Frank J Gonzalez, Wen-Cai Ye, Xin-Sheng Yao
The Xian-Ling-Gu-Bao capsule (XLGB) is a famous traditional Chinese medicine prescription (TCMP), which has proven effective in osteoporosis treatment. However, due to the lack of a dynamic XLGB profile, the in vivo pharmacokinetics of multiple bioactive components within this medicine remains unknown. In the present study, ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF-MS) identified a total of eighteen prototypes (using reference standards) in rat serum after oral administration of XLGB...
January 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28000151/the-impact-of-provider-networks-on-the-co-prescriptions-of-interacting-drugs-a-claims-based-analysis
#12
Mei-Sing Ong, Karen L Olson, Laura Chadwick, Chunfu Liu, Kenneth D Mandl
INTRODUCTION: Multiple provider prescribing of interacting drugs is a preventable cause of morbidity and mortality, and fragmented care is a major contributing factor. We applied social network analysis to examine the impact of provider patient-sharing networks on the risk of multiple provider prescribing of interacting drugs. METHODS: We performed a retrospective analysis of commercial healthcare claims (years 2008-2011), including all non-elderly adult beneficiaries (n = 88,494) and their constellation of care providers...
December 20, 2016: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/27991438/limitations-of-analytical-dose-calculations-for-small-field-proton-radiosurgery
#13
Changran Geng, Juliane Daartz, Kimberley Lam-Tin-Cheung, Marc Bussiere, Helen A Shih, Harald Paganetti, Jan Schuemann
The purpose of the work was to evaluate the dosimetric uncertainties of an analytical dose calculation engine and the impact on treatment plans using small fields in intracranial proton stereotactic radiosurgery (PSRS) for a gantry based double scattering system. 50 patients were evaluated including 10 patients for each of 5 diagnostic indications of: arteriovenous malformation (AVM), acoustic neuroma (AN), meningioma (MGM), metastasis (METS), and pituitary adenoma (PIT). Treatment plans followed standard prescription and optimization procedures for PSRS...
January 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27990038/morbid-obesity-and-use-of-second-generation-antipsychotics-among-adolescents-in-foster-care-evidence-from-medicaid
#14
Benjamin T Allaire, Ramesh Raghavan, Derek S Brown
BACKGROUND: Many adolescents enter foster care with high body mass index (BMI), and patterns of treatment further exacerbate the risk of morbid obesity. A principal risk factor for such exacerbation is the use of second generation antipsychotics (SGAs). We examine the association between receiving a morbid obesity diagnosis and SGA prescriptions among adolescents in foster care. METHODS: We analyzed claims from 36 states' Medicaid Analytic Extract (MAX) files for 2000 through 2003...
August 2016: Children and Youth Services Review
https://www.readbyqxmd.com/read/27938383/drug-related-celebrity-deaths-a-cross-sectional-study
#15
Johannes M Just, Markus Bleckwenn, Rieke Schnakenberg, Philipp Skatulla, Klaus Weckbecker
BACKGROUND: Celebrities are at risk for premature mortality as well as drug-related death. Despite being a vulnerable patient group, celebrities influence people's health behaviours through biological, psychological and social processes. Therefore, celebrity endorsement of the topic could be one way to challenge the current "opioid endemic". Our aim was to better understand the factors surrounding drug-related celebrity deaths by investigating the incidence as well as substances used between 1970 and 2015 using a cross-sectional study design...
December 9, 2016: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/27935251/simultaneous-determination-of-35-ultra-trace-level-organophosphorus-pesticide-residues-in-sanjie-zhentong-capsules-of-traditional-chinese-medicine-using-ultra-high-performance-liquid-chromatography-with-tandem-mass-spectrometry
#16
Jiachun Li, Dongpo Li, Jingling Wu, Jianping Qin, Junhua Hu, Wenzhe Huang, Zhenzhong Wang, Wei Xiao, Yu Wang
The aim of this study was to develop an analytical method for the simultaneous determination of ultra-trace levels of 35 organophosphorus pesticide residues in Sanjie Zhentong capsules, a traditional Chinese medicine prescription. A method based on multiclass and multiresidue sample preparation was developed. First, samples were hydrated with water in 4°C. A ratio of 1:3 sample/water was used for each of the sample amounts. Then, different extraction solvents were screened. This step was followed by a dispersive solid-phase extraction clean-up procedure using both primary secondary amine and polyamide...
December 9, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27929515/an-innovative-method-to-acquire-the-location-of-point-a-for-cervical-cancer-treatment-by-hdr-brachytherapy
#17
Liyun Chang, Sheng-Yow Ho, Shyh-An Yeh, Tsair-Fwu Lee, Pang-Yu Chen
Brachytherapy of local cervical cancer is generally accomplished through film-based treatment planning with the prescription directed to point A, which is invisible on images and is located at a high-dose gradient area. Through a standard reconstruction method by digitizing film points, the location error for point A would be 3mm with a condition of 30° curvature tandem, which is 10° away from the gantry rotation axis of a simulator, and has an 8.7 cm interval between the flange and the isocenter. To reduce the location error of the reconstructed point A, this paper proposes a method and demonstrates its accuracy...
November 8, 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27906782/predicting-heart-dose-in-breast-cancer-patients-who-received-3d-conformal-radiation-therapy
#18
Daniel Wollschläger, Heiko Karle, Marcus Stockinger, Detlef Bartkowiak, Sandra Bührdel, Hiltrud Merzenich, Thomas Wiegel, Heinz Schmidberger, Maria Blettner
Cardiac late effects are a major health concern for long-term survivors after radiotherapy for breast cancer. Large cohort studies to better understand the exact dose-response relationship require individual estimates of radiation dose to the heart. To predict individual cardiac dose from information that is typically available for all members of a retrospective epidemiological cohort study, 774 female breast cancer patients treated with megavoltage tangential field radiotherapy in 1998-2008 were examined. All dose distributions were calculated using Eclipse with the anisotropic analytical algorithm (AAA) for photon fields and the electron Monte Carlo algorithm for electron boost fields...
January 2017: Health Physics
https://www.readbyqxmd.com/read/27901359/buprenorphine-transdermal-system-utilization
#19
Laura Wallace, Aditi Kadakia
OBJECTIVES: To evaluate utilization patterns in patients initiating buprenorphine transdermal system (BTDS), CIII, and estimate the proportion decreasing their total opioid dose over time. METHODS: This retrospective cohort study used data from the Truven Health Analytics MarketScan® Commercial Claims and Encounters Database from 1 January 2011 through 31 December 2015. Eligible individuals were adults aged 18-64 years newly dispensed BTDS (index prescription) who had at least six months of insurance coverage prior to (baseline period) and following (study period) the index prescription...
December 15, 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27886469/quantum-simulation-of-the-factorization-problem
#20
Jose Luis Rosales, Vicente Martin
Feynman's prescription for a quantum simulator was to find a Hamitonian for a system that could serve as a computer. The Pólya-Hilbert conjecture proposed the demonstration of Riemann's hypothesis through the spectral decomposition of Hermitian operators. Here we study the problem of decomposing a number into its prime factors, N=xy, using such a simulator. First, we derive the Hamiltonian of the physical system that simulates a new arithmetic function formulated for the factorization problem that represents the energy of the computer...
November 11, 2016: Physical Review Letters
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