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https://www.readbyqxmd.com/read/28535921/out-of-field-in-vivo-dosimetry-using-tld-in-sabr-for-primary-kidney-cancer-involving-mixed-photon-fields
#1
P Lonski, S Keehan, S Siva, D Pham, R D Franich, M L Taylor, T Kron
PURPOSE: To assess out-of-field dose using three different variants of LiF thermoluminescence dosimeters (TLD) for ten patients who underwent stereotactic ablative body radiotherapy (SABR) for primary renal cell carcinoma (RCC) and compare with treatment planning system (TPS) dose calculations. METHODS AND MATERIALS: Thermoluminescent dosimeter (TLD) measurements were conducted at 20, 30, 40 and 50cm from isocentre on ten patients undergoing SABR for primary RCC...
May 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28525790/quantitative-lc-hrms-determination-of-selected-cardiovascular-drugs-in-dried-blood-spots-as-an-indicator-of-adherence-to-medication
#2
Dennis Bernieh, Graham Lawson, Sangeeta Tanna
Dried blood spot (DBS) sampling was investigated as a means of obtaining micro-volume blood samples for the quantitative analyses of ten commonly UK prescribed cardiovascular drugs as an indicator of medication adherence. An 8mm disc was punched out from each DBS from calibration, quality control and volunteer samples and extracted using methanol containing the internal standard. Each extract was evaporated to dryness, the residue reconstituted in methanol:water (40:60v/v) containing 0.1% formic acid and analysed by LC-HRMS...
May 6, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28511451/attitudes-of-mashhad-public-hospital-s-nurses-and-midwives-toward-the-causes-and-rates-of-medical-errors-reporting
#3
Sedigheh Sedigh Mobarakabadi, Hosein Ebrahimipour, Ali Vafaie Najar, Roksana Janghorban, Fatemeh Azarkish
INTRODUCTION: Patient's safety is one of the main objective in healthcare services; however medical errors are a prevalent potential occurrence for the patients in treatment systems. Medical errors lead to an increase in mortality rate of the patients and challenges such as prolonging of the inpatient period in the hospitals and increased cost. Controlling the medical errors is very important, because these errors besides being costly, threaten the patient's safety. AIM: To evaluate the attitudes of nurses and midwives toward the causes and rates of medical errors reporting...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28501464/the-connection-between-nursing-diagnosis-and-the-use-of-healthcare-resources
#4
María Consuelo Company-Sancho, Marcos Estupiñán-Ramírez, Hilda Sánchez-Janáriz, Rita Tristancho-Ajamil
AIM: The health service invests up to 75% of its resources on chronic care where the focus should be on caring rather than curing. Nursing staff focuses their work on such care. Care requires being redorded in health histories through the standardized languages. These records enable useful analyses to organisational and healthcare decision-making. Our proposal is to know the association of between nursing diagnosis and a higher total expenditure on health. METHOD: An observational cross-sectional analytical study was performed based on data from electronic health records in Primary Care (Drago-AP), hospital discharges (CMBD-AH) and prescriptions (REC-SCS) of patients over 50 from 2012-2013 in the Canary Islands...
May 10, 2017: Enfermería Clínica
https://www.readbyqxmd.com/read/28500694/trends-of-neonatal-abstinence-syndrome-epidemic-and-maternal-risk-factors-in-florida
#5
Xi Wang, Yanmin Zhu, Chintan V Dave, Adel A Alrwisan, Stacy A Voils, Almut G Winterstein
OBJECTIVE: This study aimed to examine secular trends of (i) maternal prescription opioid use in late pregnancy, (ii) neonatal abstinence syndrome (NAS) stratified by late maternal prescription opioid use, and (iii) maternal risk factors among NAS deliveries. METHODS: Women with a live birth who were enrolled 90 days before and 30 days after delivery in Florida Medicaid Analytic Extract billing records linked to birth certificates from 2000 to 2010 were identified for the study...
May 13, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28498094/predictors-of-all-cause-30-day-readmission-among-medicare-patients-with-type-2-diabetes
#6
Jenna Collins, Ibrahim M Abbass, Raymond Harvey, Brandon Suehs, Claudia Uribe, Jonathan Bouchard, Todd Prewitt, Tony DeLuzio, Elsie Allen
OBJECTIVE: Readmission is costly among patients with type 2 diabetes (T2DM) in Medicare Advantage Prescription Drug Plans; identifying high-risk patients is necessary for targeting reduction programs. The objective of this study was to develop a claims-based algorithm to predict all-cause 30-day readmission among patients with T2DM. METHODS: This study used administrative data from 1/1/2012 through 1/31/2014. The cohort included hospitalized T2DM patients, aged 18-90 with ≥12 months' continuous-enrollment before an unplanned hospital admission and ≥1 month of enrollment post-discharge, excluding patients in long-term care >30 days pre-index...
May 12, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28470636/-antibiotic-stewardship-from-bench-to-bedside
#7
Jan R Ortlepp
The article explains the practical implementation of Antibiotic Stewardship (ABS) in the clinic. With increasing prevalence of resistant bacteria, the medical profession is challenged to critically question and reduce antibiotic prescriptions. ABS programs are designed to support this. In particular, the involvement of clinic management in the ABS has to improve. There has to be a greater awareness of problems associated with antibiotic use and the data about it must be communicated transparently within the hospital...
April 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/28463780/a-novel-liquid-chromatography-tandem-mass-spectrometry-lc-ms-ms-based-bioanalytical-method-for-quantification-of-ethyl-esters-of-eicosapentaenoic-acid-epa-and-docosahexaenoic-acid-dha-and-its-application-in-pharmacokinetic-study
#8
Sekarbabu Viswanathan, P R P Verma, Muniyandithevar Ganesan, Jeganathan Manivannan
Omega-3 fatty acids are clinically useful and the two marine omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are prevalent in fish and fish oils. Omega-3 fatty acid formulations should undergo a rigorous regulatory step in order to obtain United States Food and Drug Administration (USFDA) approval as prescription drug. In connection with that, despite quantifying EPA and DHA fatty acids, there is a need for quantifying the level of ethyl esters of them in biological samples. In this study, we make use of reverse phase high performance liquid chromatography coupled with mass spectrometry (RP-HPLC-MS)technique for the method development...
April 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28457787/time-resolved-dose-rate-distributions-in-brachytherapy
#9
Vasiliki Peppa, Eleftherios P Pappas, Pantelis Karaiskos, Panagiotis Papagiannis
PURPOSE: To investigate the biological significance of introducing time-resolved dose rate distributions (TR-DRD) in brachytherapy. MATERIALS AND METHODS: The treatment plan of a head and neck patient treated with pulsed-dose-rate (PDR) brachytherapy was considered. The TR-DRD was calculated on the basis of a Monte Carlo generated single source dose rate matrix taking into account the dose rate per source dwell position. Biologically Effective Dose (BED) was obtained considering either the mean dose rate per pulse (analytical method) or the TR-DRD (numerical method)...
April 27, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28452500/quantum-corrections-in-nanoplasmonics-shape-scale-and-material
#10
Thomas Christensen, Wei Yan, Antti-Pekka Jauho, Marin Soljačić, N Asger Mortensen
The classical treatment of plasmonics is insufficient at the nanometer-scale due to quantum mechanical surface phenomena. Here, an extension of the classical paradigm is reported which rigorously remedies this deficiency through the incorporation of first-principles surface response functions-the Feibelman d parameters-in general geometries. Several analytical results for the leading-order plasmonic quantum corrections are obtained in a first-principles setting; particularly, a clear separation of the roles of shape, scale, and material is established...
April 14, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28415020/simultaneous-determination-of-ten-bioactive-constituents-of-sanjie-zhentong-capsule-in-rat-plasma-by-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-and-its-application-to-a-pharmacokinetic-study
#11
Jiachun Li, Dongpo Li, Youzhi Pan, Jun-Hua Hu, Wenzhe Huang, Zhen-Zhong Wang, Wei Xiao, Yu Wang
Sanjie Zhentong capsule, a well-known traditional Chinese medicine prescription, are used for the treatment of endometriosis-related diseases. In this study, a simple, rapid and sensitive ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed for the simultaneous determination of ten bioactive constituents, including peimine, peiminine, peimisine, loureirin A, loureirin B, 7,4'-dihydroxyflavone, pterostilbene, ginsenoside Rg1, ginsenoside Rb1, and notoginsenoside R1 in rat plasma after oral administration of Sanjie Zhentong capsule...
March 9, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28410338/multiple-sources-of-prescription-payment-and-risky-opioid-therapy-among-veterans
#12
William C Becker, Brenda T Fenton, Cynthia A Brandt, Erin L Doyle, Joseph Francis, Joseph L Goulet, Brent A Moore, Virginia Torrise, Robert D Kerns, Peter W Kreiner
BACKGROUND: Opioid overdose and other related harms are a major source of morbidity and mortality among US Veterans, in part due to high-risk opioid prescribing. OBJECTIVES: We sought to determine whether having multiple sources of payment for opioids-as a marker for out-of-system access-is associated with risky opioid therapy among veterans. RESEARCH DESIGN: Cross-sectional study examining the association between multiple sources of payment and risky opioid therapy among all individuals with Veterans Health Administration (VHA) payment for opioid analgesic prescriptions in Kentucky during fiscal year 2014-2015...
April 13, 2017: Medical Care
https://www.readbyqxmd.com/read/28399914/healthcare-burden-of-pulmonary-hypertension-owing-to-lung-disease-and-or-hypoxia
#13
Gustavo A Heresi, David M Platt, Wenyi Wang, Christine H Divers, Vijay N Joish, Simon A Teal, Justin S Yu
BACKGROUND: Group 3 pulmonary hypertension (PH) encompasses PH owing to lung diseases and/or hypoxia. Treatment patterns, healthcare resource use, and economic burden to US payers of Group 3 PH patients were assessed. METHODS: This retrospective observational study extracted data from July 1, 2010 to June 30, 2013 from two Truven Health Analytics MarketScan databases. Adult Group 3 PH patients were identified based on claims for PH (ICD-9-CM 416.0/416.8), a related lung disease, and an echocardiogram or right heart catheterization (RHC)...
April 11, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28395664/the-future-of-critical-care-renal-support-in-2027
#14
REVIEW
William R Clark, Mauro Neri, Francesco Garzotto, Zaccaria Ricci, Stuart L Goldstein, Xiaoqiang Ding, Jiarui Xu, Claudio Ronco
Since its inception four decades ago, both the clinical and technologic aspects of continuous renal replacement therapy (CRRT) have evolved substantially. Devices now specifically designed for critically ill patients with acute kidney injury are widely available and the clinical challenges associated with treating this complex patient population continue to be addressed. However, several important questions remain unanswered, leaving doubts in the minds of many clinicians about therapy prescription/delivery and patient management...
April 11, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28335036/validated-method-for-the-screening-and-quantification-of-baclofen-gabapentin-and-pregabalin-in-human-post-mortem-whole-blood-using-protein-precipitation-and-liquid-chromatography-tandem-mass-spectrometry
#15
Limon Nahar, Amy Smith, Rajan Patel, Rebecca Andrews, Sue Paterson
There has been a rapid increase in the number of prescriptions for baclofen (BLF), gabapentin (GBP) and pregabalin (PGL) in the UK since their introduction to therapy. Recent studies across the European Union and USA have shown the illicit abuse potential of these drugs and deaths have been observed. A simple, reliable and fully validated method was developed for the screening and quantification of BLF, GBP and PGL in human post-mortem (PM) blood. The analytes and their deuterated analogs as internal standard were extracted from blood using a single addition acetonitrile protein precipitation reaction followed by analysis using liquid chromatography-tandem mass spectrometry (LC-MS-MS) with triggered dynamic multiple reaction monitoring mode for simultaneous confirmation and quantification...
June 1, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28333183/machine-learning-algorithms-for-objective-remission-and-clinical-outcomes-with-thiopurines
#16
Akbar K Waljee, Kay Sauder, Anand Patel, Sandeep Segar, Boang Liu, Yiwei Zhang, Ji Zhu, Ryan W Stidham, Ulysses Balis, Peter D R Higgins
Background and Aims: Big data analytics leverage patterns in data to harvest valuable information, but are rarely implemented in clinical care. Optimising thiopurine therapy for inflammatory bowel disease [IBD] has proved difficult. Current methods using 6-thioguanine nucleotide [6-TGN] metabolites have failed in randomized controlled trials [RCTs], and have not been used to predict objective remission [OR]. Our aims were to: 1) develop machine learning algorithms [MLA] using laboratory values and age to identify patients in objective remission on thiopurines; and 2) determine whether achieving algorithm-predicted objective remission resulted in fewer clinical events per year...
March 14, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28303226/simultaneous-determination-of-14-active-constituents-of-shengjiang-xiexin-decoction-using-ultrafast-liquid-chromatography-coupled-with-electrospray-ionization-tandem-mass-spectrometry
#17
Gang Peng, Huanyu Guan, Xiaoming Wang, Yue Shi
An effective herbal medicinal prescription of Shengjiang Xiexin decoction (SXD) was used in treating the inflammatory bowel disease in clinic. In this study, an ultrafast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) method was developed to separate and to simultaneously determine 14 major active ingredients in SXD. Chromatographic separation was successfully accomplished on an Acquity BEH C18 (100 mm×2.1 mm, 1.7 μm) column using gradient elution with 0.1% (v/v) formic acid water (A) and 0...
March 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28297432/difference-in-dose-volumetric-data-between-the-analytical-anisotropic-algorithm-the-dose-to-medium-and-the-dose-to-water-reporting-modes-of-the-acuros-xb-for-lung-stereotactic-body-radiation-therapy
#18
Wambaka A Mampuya, Mitsuhiro Nakamura, Yoshinori Hirose, Takashi Ishigaki, Takashi Mizowaki, Masahiro Hiraoka
The purpose of this study was to evaluate the difference in dose-volumetric data between the analytical anisotropic algorithms (AAA) and the two dose reporting modes of the Acuros XB, namely, the dose to water (AXB-Dw) and dose to medium (AXB-Dm) in lung stereotactic body radiotherapy (SBRT). Thirty-eight plans were generated using the AXB-Dm in Eclipse Treatment Planning System (TPS) and then recalculated with the AXB-Dw and AAA, using identical beam setup. A dose of 50 Gy in 4 fractions was prescribed to the isocenter and the planning target volume (PTV) D95%...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297280/an-innovative-method-to-acquire-the-location-of-point-a-for-cervical-cancer-treatment-by-hdr-brachytherapy
#19
Liyun Chang, Sheng-Yow Ho, Shyh-An Yeh, Tsair-Fwu Lee, Pang-Yu Chen
Brachytherapy of local cervical cancer is generally accomplished through film-based treatment planning with the prescription directed to point A, which is invisible on images and is located at a high-dose gradient area. Through a standard reconstruction method by digitizing film points, the location error for point A would be 3 mm with a condition of 30° curvature tandem, which is 10° away from the gantry rotation axis of a simulator, and has an 8.7 cm interval between the flange and the isocenter. To reduce the location error of the reconstructed point A, this paper proposes a method and demonstrates its accuracy...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28263920/healthcare-costs-and-utilization-for-patients-age-50-to-64-years-with-acute-myeloid-leukemia-treated-with-chemotherapy-or-with-chemotherapy-and-allogeneic-hematopoietic-cell-transplantation
#20
Jaime M Preussler, Christa L Meyer, Lih-Wen Mau, Navneet S Majhail, Ellen M Denzen, Kristen C Edsall, Stephanie H Farnia, Wael Saber, Linda J Burns, David J Vanness
The primary aim of this study was to describe healthcare costs and utilization during the first year after a diagnosis of acute myeloid leukemia (AML) for privately insured non-Medicare patients in the United States aged 50 to 64 years who were treated with either chemotherapy or chemotherapy and allogeneic hematopoietic cell transplantation (alloHCT). MarketScan (Truven Health Analytics) adjudicated total payments for inpatient, outpatient, and prescription drug claims from 2007 to 2011 were used to estimate costs from the health system perspective...
March 2, 2017: Biology of Blood and Marrow Transplantation
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