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https://www.readbyqxmd.com/read/28415020/simultaneous-determination-of-ten-bioactive-constituents-of-sanjie-zhentong-capsule-in-rat-plasma-by-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-and-its-application-to-a-pharmacokinetic-study
#1
Jiachun Li, Dongpo Li, Youzhi Pan, Jun-Hua Hu, Wenzhe Huang, Zhen-Zhong Wang, Wei Xiao, Yu Wang
Sanjie Zhentong capsule, a well-known traditional Chinese medicine prescription, are used for the treatment of endometriosis-related diseases. In this study, a simple, rapid and sensitive ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed for the simultaneous determination of ten bioactive constituents, including peimine, peiminine, peimisine, loureirin A, loureirin B, 7,4'-dihydroxyflavone, pterostilbene, ginsenoside Rg1, ginsenoside Rb1, and notoginsenoside R1 in rat plasma after oral administration of Sanjie Zhentong capsule...
March 9, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28410338/multiple-sources-of-prescription-payment-and-risky-opioid-therapy-among-veterans
#2
William C Becker, Brenda T Fenton, Cynthia A Brandt, Erin L Doyle, Joseph Francis, Joseph L Goulet, Brent A Moore, Virginia Torrise, Robert D Kerns, Peter W Kreiner
BACKGROUND: Opioid overdose and other related harms are a major source of morbidity and mortality among US Veterans, in part due to high-risk opioid prescribing. OBJECTIVES: We sought to determine whether having multiple sources of payment for opioids-as a marker for out-of-system access-is associated with risky opioid therapy among veterans. RESEARCH DESIGN: Cross-sectional study examining the association between multiple sources of payment and risky opioid therapy among all individuals with Veterans Health Administration (VHA) payment for opioid analgesic prescriptions in Kentucky during fiscal year 2014-2015...
April 13, 2017: Medical Care
https://www.readbyqxmd.com/read/28399914/healthcare-burden-of-pulmonary-hypertension-owing-to-lung-disease-and-or-hypoxia
#3
Gustavo A Heresi, David M Platt, Wenyi Wang, Christine H Divers, Vijay N Joish, Simon A Teal, Justin S Yu
BACKGROUND: Group 3 pulmonary hypertension (PH) encompasses PH owing to lung diseases and/or hypoxia. Treatment patterns, healthcare resource use, and economic burden to US payers of Group 3 PH patients were assessed. METHODS: This retrospective observational study extracted data from July 1, 2010 to June 30, 2013 from two Truven Health Analytics MarketScan databases. Adult Group 3 PH patients were identified based on claims for PH (ICD-9-CM 416.0/416.8), a related lung disease, and an echocardiogram or right heart catheterization (RHC)...
April 11, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28395664/the-future-of-critical-care-renal-support-in-2027
#4
REVIEW
William R Clark, Mauro Neri, Francesco Garzotto, Zaccaria Ricci, Stuart L Goldstein, Xiaoqiang Ding, Jiarui Xu, Claudio Ronco
Since its inception four decades ago, both the clinical and technologic aspects of continuous renal replacement therapy (CRRT) have evolved substantially. Devices now specifically designed for critically ill patients with acute kidney injury are widely available and the clinical challenges associated with treating this complex patient population continue to be addressed. However, several important questions remain unanswered, leaving doubts in the minds of many clinicians about therapy prescription/delivery and patient management...
April 11, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28335036/validated-method-for-the-screening-and-quantification-of-baclofen-gabapentin-and-pregabalin-in-human-post-mortem-whole-blood-using-protein-precipitation-and-liquid-chromatography-tandem-mass-spectrometry
#5
Limon Nahar, Amy Smith, Rajan Patel, Rebecca Andrews, Sue Paterson
There has been a rapid increase in the number of prescriptions for baclofen (BLF), gabapentin (GBP) and pregabalin (PGL) in the UK since their introduction to therapy. Recent studies across the European Union and USA have shown the illicit abuse potential of these drugs and deaths have been observed. A simple, reliable and fully validated method was developed for the screening and quantification of BLF, GBP and PGL in human post-mortem (PM) blood. The analytes and their deuterated analogs as internal standard were extracted from blood using a single addition acetonitrile protein precipitation reaction followed by analysis using liquid chromatography-tandem mass spectrometry (LC-MS-MS) with triggered dynamic multiple reaction monitoring mode for simultaneous confirmation and quantification...
March 10, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28333183/machine-learning-algorithms-for-objective-remission-and-clinical-outcomes-with-thiopurines
#6
Akbar K Waljee, Kay Sauder, Anand Patel, Sandeep Segar, Boang Liu, Yiwei Zhang, Ji Zhu, Ryan W Stidham, Ulysses Balis, Peter D R Higgins
Background and Aims: Big data analytics leverage patterns in data to harvest valuable information, but are rarely implemented in clinical care. Optimising thiopurine therapy for inflammatory bowel disease [IBD] has proved difficult. Current methods using 6-thioguanine nucleotide [6-TGN] metabolites have failed in randomized controlled trials [RCTs], and have not been used to predict objective remission [OR]. Our aims were to: 1) develop machine learning algorithms [MLA] using laboratory values and age to identify patients in objective remission on thiopurines; and 2) determine whether achieving algorithm-predicted objective remission resulted in fewer clinical events per year...
March 14, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28303226/simultaneous-determination-of-14-active-constituents-of-shengjiang-xiexin-decoction-using-ultrafast-liquid-chromatography-coupled-with-electrospray-ionization-tandem-mass-spectrometry
#7
Gang Peng, Huanyu Guan, Xiaoming Wang, Yue Shi
An effective herbal medicinal prescription of Shengjiang Xiexin decoction (SXD) was used in treating the inflammatory bowel disease in clinic. In this study, an ultrafast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) method was developed to separate and to simultaneously determine 14 major active ingredients in SXD. Chromatographic separation was successfully accomplished on an Acquity BEH C18 (100 mm×2.1 mm, 1.7 μm) column using gradient elution with 0.1% (v/v) formic acid water (A) and 0...
March 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28297432/difference-in-dose-volumetric-data-between-the-analytical-anisotropic-algorithm-the-dose-to-medium-and-the-dose-to-water-reporting-modes-of-the-acuros-xb-for-lung-stereotactic-body-radiation-therapy
#8
Wambaka A Mampuya, Mitsuhiro Nakamura, Yoshinori Hirose, Takashi Ishigaki, Takashi Mizowaki, Masahiro Hiraoka
The purpose of this study was to evaluate the difference in dose-volumetric data between the analytical anisotropic algorithms (AAA) and the two dose reporting modes of the Acuros XB, namely, the dose to water (AXB-Dw) and dose to medium (AXB-Dm) in lung stereotactic body radiotherapy (SBRT). Thirty-eight plans were generated using the AXB-Dm in Eclipse Treatment Planning System (TPS) and then recalculated with the AXB-Dw and AAA, using identical beam setup. A dose of 50 Gy in 4 fractions was prescribed to the isocenter and the planning target volume (PTV) D95%...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297280/an-innovative-method-to-acquire-the-location-of-point-a-for-cervical-cancer-treatment-by-hdr-brachytherapy
#9
Liyun Chang, Sheng-Yow Ho, Shyh-An Yeh, Tsair-Fwu Lee, Pang-Yu Chen
Brachytherapy of local cervical cancer is generally accomplished through film-based treatment planning with the prescription directed to point A, which is invisible on images and is located at a high-dose gradient area. Through a standard reconstruction method by digitizing film points, the location error for point A would be 3 mm with a condition of 30° curvature tandem, which is 10° away from the gantry rotation axis of a simulator, and has an 8.7 cm interval between the flange and the isocenter. To reduce the location error of the reconstructed point A, this paper proposes a method and demonstrates its accuracy...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28263920/healthcare-costs-and-utilization-for-patients-age-50-to-64-years-with-acute-myeloid-leukemia-treated-with-chemotherapy-or-with-chemotherapy-and-allogeneic-hematopoietic-cell-transplantation
#10
Jaime M Preussler, Christa L Meyer, Lih-Wen Mau, Navneet S Majhail, Ellen Denzen, Kristen C Edsall, Stephanie H Farnia, Wael Saber, Linda J Burns, David J Vanness
The primary aim of this study was to describe healthcare costs and utilization during the first year after a diagnosis of acute myeloid leukemia (AML) for privately insured non-Medicare patients in the United States aged 50 to 64 years who were treated with either chemotherapy or chemotherapy and allogeneic hematopoietic cell transplantation (alloHCT). MarketScan (Truven Health Analytics) adjudicated total payments for inpatient, outpatient, and prescription drug claims from 2007 to 2011 were used to estimate costs from the health system perspective...
March 2, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28258074/cost-effectiveness-of-watchful-waiting-in-acute-otitis-media
#11
Di Sun, T J McCarthy, Danica B Liberman
BACKGROUND: American Academy of Pediatrics guidelines for acute otitis media (AOM) allow for children meeting certain criteria to undergo watchful waiting (WW). The cost-effectiveness of this policy has not been evaluated in the United States. METHODS: A retrospective review of a random selection of 250 patients ≤18 years old with AOM in the emergency department of a tertiary care children's hospital was used to characterize current practice of AOM management...
March 3, 2017: Pediatrics
https://www.readbyqxmd.com/read/28191359/simultaneous-determination-of-5-flavonoids-and-7-saponins-for-quality-control-of-traditional-chinese-medicine-preparation-xinnaoshutong-capsule-using-hplc-vwd-elsd
#12
Jin Li, Yang Bai, Peng Zhang, Jun He, Jun Cao, Mingrui An, Li-Min Hu, Xiu-Mei Gao, Yan-Xu Chang
Xinnaoshutong capsule (XC) is a traditional Chinese prescription derived from the ripe fruit of Tribulus terrestris L. (TT). Although XC has long been considered as an important herbal medicine, no analytical method of marker compounds for quality assessment is registered in the Chinese Pharmacopoeia. A simple analytical method of twelve marker components was developed and validated by HPLC-VWD-ELSD method. Chromatographic separation by HPLC was carried out on a Hedera ODS 2 column (4.6 × 250 mm, 5 μm) by gradient elution with acetonitrile-water (0...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28186924/can-purchasing-information-be-used-to-predict-adherence-to-cardiovascular-medications-an-analysis-of-linked-retail-pharmacy-and-insurance-claims-data
#13
Alexis A Krumme, Gabriel Sanfélix-Gimeno, Jessica M Franklin, Danielle L Isaman, Mufaddal Mahesri, Olga S Matlin, William H Shrank, Troyen A Brennan, Gregory Brill, Niteesh K Choudhry
OBJECTIVE: The use of retail purchasing data may improve adherence prediction over approaches using healthcare insurance claims alone. DESIGN: Retrospective. SETTING AND PARTICIPANTS: A cohort of patients who received prescription medication benefits through CVS Caremark, used a CVS Pharmacy ExtraCare Health Care (ECHC) loyalty card, and initiated a statin medication in 2011. OUTCOME: We evaluated associations between retail purchasing patterns and optimal adherence to statins in the 12 subsequent months...
November 9, 2016: BMJ Open
https://www.readbyqxmd.com/read/28186712/a-practical-methodology-for-disaggregating-the-drivers-of-drug-costs-using-administrative-data
#14
Elena R Lungu, Orlando J Manti, Mitchell A H Levine, Douglas A Clark, Tanya M Potashnik, Carol I McKinley
BACKGROUND: Prescription drug expenditures represent a significant component of health care costs in Canada, with estimates of $28.8 billion spent in 2014. Identifying the major cost drivers and the effect they have on prescription drug expenditures allows policy makers and researchers to interpret current cost pressures and anticipate future expenditure levels. OBJECTIVES: To identify the major drivers of prescription drug costs and to develop a methodology to disaggregate the impact of each of the individual drivers...
September 1, 2017: Journal of Population Therapeutics and Clinical Pharmacology
https://www.readbyqxmd.com/read/28186006/what-we-can-learn-from-amazon-for-clinical-decision-support-systems
#15
Sidra Abid, Karim Keshavjee, Arsalan Karim, Aziz Guergachi
Health care continue to lag behind other industries, such as retail and financial services, in the use of decision-support-like tools. Amazon is particularly prolific in the use of advanced predictive and prescriptive analytics to assist its customers to purchase more, while increasing satisfaction, retention, repeat-purchases and loyalty. How can we do the same in health care? In this paper, we explore various elements of the Amazon website and Amazon's data science and big data practices to gather inspiration for re-designing clinical decision support in the health care sector...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28147306/rapid-determination-of-30-bioactive-constituents-in-xuebijing-injection-using-ultra-high-performance-liquid-chromatography-high-resolution-hybrid-quadrupole-orbitrap-mass-spectrometry-coupled-with-principal-component-analysis
#16
Lihua Zuo, Zhi Sun, Yurong Hu, Ya Sun, Wenhua Xue, Lin Zhou, Jun Zhang, Xiaoyue Bao, Zhenfeng Zhu, Guanglu Suo, Xiaojian Zhang
Xuebijing injection (XBJ) is a traditional Chinese herbal prescription widely used in the treatment of sepsis. Extensive chemical studies revealed that XBJ injection contains amino acids, phenolic acids, flavonoid glycosides, terpeneglycosides and phthalides. In this study, the applicability of ultra high performance liquid chromatography coupled with high resolution hybrid quadruple-orbitrap mass spectrometry (UHPLC-Q-Orbitrap MS) for the simultaneous quantitative analysis of 30 bioactive constituents in XueBiJing injection (XBJ) was investigated...
January 12, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28135840/annals-express-a-systematic-evaluation-of-immunoassay-point-of-care-testing-to-define-impact-on-patients-outcomes
#17
Valentina Pecoraro, Giuseppe Banfi, Luca Germagnoli, Tommaso Trenti
BACKGROUND: Point of Care testing (POCT) has been developed to provide rapid test results. Most published studies focus on analytical performance, neglecting its impact on patient outcomes. OBJECTIVE: To review the analytical performance and accuracy of POCT specifically planned for immunoassay, and to evaluate the impact of faster results on patient management. METHODS: A search of electronic databases for studies reporting immunoassay results obtained in both POCT and central laboratory scenarios was performed...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28131938/rapid-analysis-of-aurantii-fructus-immaturus-zhishi-using-paper-spray-ionization-mass-spectrometry
#18
Xuemei Liu, Zhixin Gu, Yuan Guo, Jingjing Liu, Ming Ma, Bo Chen, Liping Wang
Paper spray-mass spectrometry (PS-MS) is a rapid, solvent-efficient, and high-throughput analytical method for analyzing complex samples. In this study, a PS-MS method was developed to obtain MS profiles of Aurantii Fructus Immaturus (aka Zhishi in Chinese) in positive and negative ion modes. In combination with multivariate analyses, including principal component analysis and cluster analysis, the PS-MS profiles of 25 batches of Zhishi were discriminated in 25 batches of Citri Reticulatae Pericarpium Viride (aka Qingpi in Chinese; an adulterant of Zhishi)...
January 22, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28115618/tumour-chemotherapy-strategy-based-on-impulse-control-theory
#19
Hai-Peng Ren, Yan Yang, Murilo S Baptista, Celso Grebogi
Chemotherapy is a widely accepted method for tumour treatment. A medical doctor usually treats patients periodically with an amount of drug according to empirical medicine guides. From the point of view of cybernetics, this procedure is an impulse control system, where the amount and frequency of drug used can be determined analytically using the impulse control theory. In this paper, the stability of a chemotherapy treatment of a tumour is analysed applying the impulse control theory. The globally stable condition for prescription of a periodic oscillatory chemotherapeutic agent is derived...
March 6, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28107295/healthcare-transformation-and-changing-roles-for-nursing
#20
Susan W Salmond, Mercedes Echevarria
Factors driving healthcare transformation include fragmentation, access problems, unsustainable costs, suboptimal outcomes, and disparities. Cost and quality concerns along with changing social and disease-type demographics created the greatest urgency for the need for change. Caring for and paying for medical treatments for patients suffering from chronic health conditions are a significant concern. The Affordable Care Act includes programs now led by the Centers for Medicare & Medicaid Services aiming to improve quality and control cost...
January 2017: Orthopaedic Nursing
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