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https://www.readbyqxmd.com/read/28711478/dosimetric-comparison-of-peripheral-nsclc-sbrt-using-acuros-xb-and-aaa-calculation-algorithms
#1
Chloe C H Ong, Khong Wei Ang, Roger C X Soh, Kah Ming Tin, Jerome H H Yap, James C L Lee, Christopher M Bragg
There is a concern for dose calculation in highly heterogenous environments such as the thorax region. This study compares the quality of treatment plans of peripheral non-small cell lung cancer (NSCLC) stereotactic body radiation therapy (SBRT) using 2 calculation algorithms, namely, Eclipse Anisotropic Analytical Algorithm (AAA) and Acuros External Beam (AXB), for 3-dimensional conformal radiation therapy (3DCRT) and volumetric-modulated arc therapy (VMAT). Four-dimensional computed tomography (4DCT) data from 20 anonymized patients were studied using Varian Eclipse planning system, AXB, and AAA version 10...
July 12, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28709229/phenomenology-of-stochastic-exponential-growth
#2
Dan Pirjol, Farshid Jafarpour, Srividya Iyer-Biswas
Stochastic exponential growth is observed in a variety of contexts, including molecular autocatalysis, nuclear fission, population growth, inflation of the universe, viral social media posts, and financial markets. Yet literature on modeling the phenomenology of these stochastic dynamics has predominantly focused on one model, geometric Brownian motion (GBM), which can be described as the solution of a Langevin equation with linear drift and linear multiplicative noise. Using recent experimental results on stochastic exponential growth of individual bacterial cell sizes, we motivate the need for a more general class of phenomenological models of stochastic exponential growth, which are consistent with the observation that the mean-rescaled distributions are approximately stationary at long times...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28705340/-factors-of-compliance-with-the-wearing-of-elastic-compression-stockings-in-a-sub-saharan-population
#3
E Soya, J J N'djessan, J Koffi, E Monney, E Tano, C Konin
INTRODUCTION: Elastic venous compression is the basic treatment of chronic venous insufficiency (CVI) and deep vein thrombosis (DVT). Very little data exist in sub-Saharan Africa concerning the wearing of compression stockings. AIM: To determine the factors of compliance with wearing elastic compression stockings. MATERIALS AND METHODS: This retrospective cross-sectional descriptive and analytical study involved 200 consecutive patients (93 cases of DVT, 94 cases of CVI, 13 cases of DVT and CVI)...
July 2017: J Med Vasc
https://www.readbyqxmd.com/read/28686397/-preanalytical-step-in-bacteriology-a-practical-overview-for-family-physicians
#4
Myriam M Eyer, Sara Droz
Physicians play a key role in the accuracy of bacteriological results by appropriate prescription and the quality of sample collection, preservation and transport. Samples for diagnostic purposes are of use if analysis results have an impact on the therapeutic approach. They have minimal risk of contamination, are usually obtained invasively, and may be targeted to detection of specific bacteria. Physicians should refer to the laboratory technical manual to provide proper sample quality. Furthermore, they have to provide clinical and administrative information to the microbiologist, because the laboratory analytical process depends on these...
October 12, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28649066/simultaneous-determination-and-pharmacokinetics-of-eight-ginsenosides-by-lc-ms-ms-after-intravenously-infusion-of-shenmai-injection-in-dogs
#5
Jian Yu, Li-Qiang Gu, Yan-Fei Xin, Hai-Yan Gao, Xiao-Zhen Xu, Sheng Zhang, Guo-Liang Zhou, Zhen-Qiang You, Li-Ru Huo, Yao-Xian Xuan
SHENMAI injection, a prescription comprised of Panax ginseng and Ophiopogon japonicas, is being extensively applied in the field of cardio-protection and immune-modulation in China. Ginsenosides are the main active components in SHENMAI injection. In order to capture and analyze the pharmacokinetic profile of major ginsenosides of SHENMAI injection in Beagle dogs, liquid chromatography equipped with electro-spray ionization and tandem mass spectrometry method was applied in simultaneous determination for protopanaxatriol type ginsenoside (Re, Rf, Rg1), protopanaxadiol type ginsenoside (Rb2, Rb1, Rd, Rc) and oleanolic acid type ginsenoside (Ro)...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28634456/absolute-and-relative-training-load-and-its-relation-to-fatigue-in-football
#6
Unai Zurutuza, Julen Castellano, Ibon Echeazarra, David Casamichana
The aim of the study was to assess the relationship of external and internal training load (TL) indicators with the objective and subjective fatigue experienced by 15 semi-professional football players, over eight complete weeks of the competition period in the 2015-2016 season, which covered microcycles from 34th to 41st. The maximum heart rate (HRmax) and maximum speed (Vmax) of all the players were previously measured in specific tests. The TL was monitored via questionnaires on rating of perceived exertion (RPE), pulsometers and GPS devices, registering the variables: total distance (TD), player load 2D (PL2D), TD at >80% of the Vmax (TD80), TD in deceleration at < -2 m⋅sec-2 (TDD <-2), TD in acceleration >2 m⋅sec(-2) (TDA >2), Edwards (ED), time spent at between 50 and 80% (50-80% HRmax), 80-90% (80-90% HRmax), and >90% of the HRmax (>90% HRmax), and RPE both respiratory/thoracic (RPEres) and leg/muscular (RPEmus)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28630505/analytical-evaluation-of-the-accuracy-and-retention-of-compounding-skills-among-pharmd-students
#7
Mudit Mudit, Lloyd F Alfonso
Objective. To evaluate the accuracy and retention of compounding skills among students using analytical testing. Methods. Students compounded acetaminophen capsules from the same prescription at three time points (Exercise 1, 2, 3). The compounded products were analyzed (by HPLC) for acetaminophen content and the students' written reports were evaluated for accuracy of calculations and labeling. Results. During Exercise 1, 57.8% of the compounded capsule products were within the acceptable range, 92.2% during Exercise 2 and 75% during Exercise 3...
May 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28629442/treatment-patterns-healthcare-resource-utilization-and-costs-following-first-line-antidepressant-treatment-in-major-depressive-disorder-a-retrospective-us-claims-database-analysis
#8
Geneviève Gauthier, Annie Guérin, Maryia Zhdanava, William Jacobson, George Nomikos, Elizabeth Merikle, Clément François, Vanessa Perez
BACKGROUND: Although the symptoms of major depressive disorder (MDD) are often manageable with pharmacotherapy, response to first-line antidepressant treatment is often less than optimal. This study describes long-term treatment patterns in MDD patients in the United States and quantifies the economic burden associated with different treatment patterns following first-line antidepressant therapy. METHODS: MDD patients starting first-line antidepressant monotherapy and having continuous enrollment ≥12 months before and ≥24 months following the index date (i...
June 19, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28626829/socioeconomic-status-as-an-effect-modifier-of-alcohol-consumption-and-harm-analysis-of-linked-cohort-data
#9
Srinivasa Vittal Katikireddi, Elise Whitley, Jim Lewsey, Linsay Gray, Alastair H Leyland
BACKGROUND: Alcohol-related mortality and morbidity are high in socioeconomically disadvantaged populations compared with individuals from advantaged areas. It is unclear if this increased harm reflects differences in alcohol consumption between these socioeconomic groups, reverse causation (ie, downward social selection for high-risk drinkers), or a greater risk of harm in individuals of low socioeconomic status compared with those of higher status after similar consumption. We aimed to investigate whether the harmful effects of alcohol differ by socioeconomic status, accounting for alcohol consumption and other health-related factors...
June 2017: Lancet. Public Health
https://www.readbyqxmd.com/read/28623381/-the-use-of-prescription-drugs-with-dependence-potential-in-germany-a-prospective-analysis-of-prescriptions-in-the-public-healthcare-system-between-2006-and-2010
#10
Sven Buth, Rüdiger Holzbach, Moritz Rosenkranz, Uwe Verthein
BACKGROUND: In Germany, about 1.4 to 2.6 million people are dependent on prescription drugs, mainly benzodiazepine derivatives and opioid analgesics. Despite this large number of affected people, studies on prescription behaviour and drug intake are scarce. There are particularly few empirical findings available with regard to elderly people age 65 and over who are disproportionally affected by prescription drug abuse. METHODS: The North German Pharmacy Computing Centre (Norddeutsches Apothekenrechenzentrum, NARZ) collects the prescription data of about 11 million citizens and covers over 80% of drug pharmacies in North Germany...
June 16, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28617210/antipsychotic-medication-use-among-publicly-insured-pregnant-women-in-the-united-states
#11
Yoonyoung Park, Krista F Huybrechts, Jacqueline M Cohen, Brian T Bateman, Rishi J Desai, Elisabetta Patorno, Helen Mogun, Lee S Cohen, Sonia Hernandez-Diaz
OBJECTIVE: Given the increasing use and broadening of indications for use of antipsychotic medications in the general population, as well as the paucity of information on the safety of this drug class during pregnancy, the study documented patterns of antipsychotic medication use among pregnant women. METHODS: Medicaid Analytic eXtract data (2001-2010) from pregnant women who delivered live-born infants were used. Antipsychotic use at both the class and the individual drug level was defined based on dispensed outpatient prescriptions...
June 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28610704/variation-of-the-prescription-dose-using-the-analytical-anisotropic-algorithm-in-lung-stereotactic-body-radiation-therapy
#12
Daisuke Kawai, Ryo Takahashi, Tatsuya Kamima, Hiromi Baba, Toshijiro Yamamoto, Yoko Kubo, Satoru Ishibashi, Yoshihiro Higuchi, Kensuke Tani, Norifumi Mizuno, Shunta Jinno, Hidenobu Tachibana
PURPOSE: The aim of the present investigation was to evaluate the dosimetric variation regarding the analytical anisotropic algorithm (AAA) relative to other algorithms in lung stereotactic body radiation therapy (SBRT). We conducted a multi-institutional study involving six institutions using a secondary check program and compared the AAA to the Acuros XB (AXB) in two institutions. METHODS: All lung SBRT plans (128 patients) were generated using the AAA, pencil beam convolution with the Batho (PBC-B) and adaptive convolve (AC)...
June 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28607686/improving-care-for-patients-with-or-at-risk-for-chronic-kidney-disease-using-electronic-medical-record-interventions-a-pragmatic-cluster-randomized-trial-protocol
#13
Danielle M Nash, Noah M Ivers, Jacqueline Young, R Liisa Jaakkimainen, Amit X Garg, Karen Tu
BACKGROUND: Many patients with or at risk for chronic kidney disease (CKD) in the primary care setting are not receiving recommended care. OBJECTIVE: The objective of this study is to determine whether a multifaceted, low-cost intervention compared with usual care improves the care of patients with or at risk for CKD in the primary care setting. DESIGN: A pragmatic cluster-randomized trial, with an embedded qualitative process evaluation, will be conducted...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/28605829/application-of-metabolomics-to-quality-control-of-natural-product-derived-medicines
#14
REVIEW
Kyung-Min Lee, Jun-Yeong Jeon, Byeong-Ju Lee, Hwanhui Lee, Hyung-Kyoon Choi
Metabolomics has been used as a powerful tool for the analysis and quality assessment of the natural product (NP)-derived medicines. It is increasingly being used in the quality control and standardization of NP-derived medicines because they are composed of hundreds of natural compounds. The most common techniques that are used in metabolomics consist of NMR, GC-MS, and LC-MS in combination with multivariate statistical analyses including principal components analysis (PCA) and partial least squares-discriminant analysis (PLS-DA)...
June 14, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28603704/relationship-between-self-efficacy-and-physical-activity-medication-adherence-in-chronic-disease-patients
#15
Seyde Shahrbanoo Daniali, Firooze Mostafavi Darani, Ahmad Ali Eslami, Mohammad Mazaheri
BACKGROUND: The global epidemic of unhealthy lifestyle causes to increase chronic disease. It has been proven that psychological factors such as self-efficacy are responsible to success in the process of lifestyle change. Low self-efficacy is usually related to low level of physical activity and medication adherence. Objective of the study was to investigate the effects of self-efficacy, other physical symptoms on physical activity and medication adherence in patients with chronic illness in public health centers...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28603522/analytical-prediction-of-the-spatiotemporal-distribution-of-chemoattractants-around-their-source-theory-and-application-to-complement-mediated-chemotaxis
#16
Volkmar Heinrich, Wooten D Simpson, Emmet A Francis
The ability of motile immune cells to detect and follow gradients of chemoattractant is critical to numerous vital functions, including their recruitment to sites of infection and-in emerging immunotherapeutic applications-to malignant tumors. Facilitated by a multitude of chemotactic receptors, the cells navigate a maze of stimuli to home in on their target. Distinct chemotactic processes direct this navigation at particular times and cell-target distances. The expedient coordination of this spatiotemporal hierarchy of chemotactic stages is the central element of a key paradigm of immunotaxis...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28600832/investigation-of-drug-products-received-for-analysis-in-the-swedish-strida-project-on-new-psychoactive-substances
#17
Matilda Bäckberg, Karl-Henrik Jönsson, Anders Helander, Olof Beck
The web-based open sale of unregulated new psychoactive substances (NPS) has shown a steady increase over the past years. Analysis of drug products sold as NPS is useful to confirm the true chemical contents, for comparison with the substances detected in corresponding body fluids, but also to study drug trends. This work describes the examination of 251 drug products that were randomly submitted for analysis in 173 cases of suspected NPS-related intoxications in the Swedish STRIDA project in 2010-2015. Of the products, 39% were powders/crystals, 32% tablets/capsules, 16% herbal materials, 8% liquids, 1% blotters, and 4% others...
June 9, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28584545/nonadherence-behaviors-and-some-related-factors-in-kidney-transplant-recipients
#18
Pari Hedayati, Nahid Shahgholian, Ahmad Ghadami
BACKGROUND: Kidney transplantation is the renal replacement therapy of choice for most patients with end-stage renal disease (ESRD), however, adherence to the recommended lifestyle is critical for a positive prognosis. The purpose of this study was to assess adherence to immunosuppressive therapy and lifestyle recommendations along with some related factors among kidney transplant patients. MATERIALS AND METHODS: In this descriptive analytical study, all patients completed a questionnaire regarding medication intake and lifestyle recommendations (preventing of infection, self-monitoring, prevention of cardiovascular disease (CVD), and sun protection)...
March 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/28581025/clinical-characteristics-and-treatment-patterns-among-patients-diagnosed-with-cluster-headache-in-u-s-healthcare-claims-data
#19
Casey K Choong, Janet H Ford, Allen W Nyhuis, Shivang G Joshi, Rebecca L Robinson, Sheena K Aurora, James M Martinez
OBJECTIVE: To characterize demographics, clinical characteristics, and treatment patterns of patients with cluster headache (CH). BACKGROUND: CH is an uncommon trigeminal autonomic cephalalgia with limited evidence-based treatment options. Patients suffer from extremely painful unilateral headache attacks and autonomic symptoms with episodic and chronic cycles. DESIGN/METHODS: This retrospective analysis used insurance claims from Truven Health Analytics MarketScan(®) research databases from 2009 to 2014...
June 5, 2017: Headache
https://www.readbyqxmd.com/read/28549568/using-visual-analytics-for-presenting-comparative-information-on-new-drugs
#20
Jean-Baptiste Lamy, Hélène Berthelot, Madeleine Favre, Adrien Ugon, Catherine Duclos, Alain Venot
OBJECTIVE: When a new drug is marketed, physicians must decide whether they will consider it for their future practice. However, information about new drugs can be biased or hard to find. In this work, our objective was to study whether visual analytics could be used for comparing drug properties such as contraindications and adverse effects, and whether this visual comparison can help physicians to forge their own well-founded opinions about a new drug. MATERIALS AND METHODS: First, an ontology for comparative drug information was designed, based on the expectations expressed during focus groups comprised of physicians...
July 2017: Journal of Biomedical Informatics
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